Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2086142693', 'doi': 'https://doi.org/10.1126/science.288.5464.331', 'title': 'Chaperone Selection During Glycoprotein Translocation into the Endoplasmic Reticulum', 'display_name': 'Chaperone Selection During Glycoprotein Translocation into the Endoplasmic Reticulum', 'publication_year': 2000, 'publication_date': '2000-04-14', 'ids': {'openalex': 'https://openalex.org/W2086142693', 'doi': 'https://doi.org/10.1126/science.288.5464.331', 'mag': '2086142693', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10764645'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.288.5464.331', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012945125', 'display_name': 'Maurizio Molinari', 'orcid': 'https://orcid.org/0000-0002-7636-5829'}, 'institutions': [], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Maurizio Molinari', 'raw_affiliation_strings': ['Swiss Federal Institute of Technology Zurich (ETHZ), Universitätstrasse 16, CH-8092 Zurich, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'Swiss Federal Institute of Technology Zurich (ETHZ), Universitätstrasse 16, CH-8092 Zurich, Switzerland.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057675183', 'display_name': 'Ari Helenius', 'orcid': None}, 'institutions': [], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Ari Helenius', 'raw_affiliation_strings': ['Swiss Federal Institute of Technology Zurich (ETHZ), Universitätstrasse 16, CH-8092 Zurich, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'Swiss Federal Institute of Technology Zurich (ETHZ), Universitätstrasse 16, CH-8092 Zurich, Switzerland.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 11.927, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 331, 'citation_normalized_percentile': {'value': 0.999807, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '288', 'issue': '5464', 'first_page': '331', 'last_page': '333'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Immunotoxin Therapy for Cancer Treatment', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Infection and Treatment', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/calnexin', 'display_name': 'Calnexin', 'score': 0.9599609}, {'id': 'https://openalex.org/keywords/chaperone', 'display_name': 'Chaperone (clinical)', 'score': 0.81567466}, {'id': 'https://openalex.org/keywords/protein-folding', 'display_name': 'Protein Folding', 'score': 0.574142}, {'id': 'https://openalex.org/keywords/endoplasmic-reticulum', 'display_name': 'Endoplasmic Reticulum', 'score': 0.516888}], 'concepts': [{'id': 'https://openalex.org/C130361206', 'wikidata': 'https://www.wikidata.org/wiki/Q908443', 'display_name': 'Calnexin', 'level': 4, 'score': 0.9599609}, {'id': 'https://openalex.org/C47450691', 'wikidata': 'https://www.wikidata.org/wiki/Q634510', 'display_name': 'Calreticulin', 'level': 3, 'score': 0.90631783}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.85923487}, {'id': 'https://openalex.org/C2775962898', 'wikidata': 'https://www.wikidata.org/wiki/Q5073152', 'display_name': 'Chaperone (clinical)', 'level': 2, 'score': 0.81567466}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.71091866}, {'id': 'https://openalex.org/C206212055', 'wikidata': 'https://www.wikidata.org/wiki/Q2553138', 'display_name': 'Glycan', 'level': 3, 'score': 0.6104977}, {'id': 'https://openalex.org/C204328495', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein folding', 'level': 2, 'score': 0.53146374}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5022683}, {'id': 'https://openalex.org/C199229279', 'wikidata': 'https://www.wikidata.org/wiki/Q610647', 'display_name': 'Translocon', 'level': 4, 'score': 0.49563992}, {'id': 'https://openalex.org/C2777313579', 'wikidata': 'https://www.wikidata.org/wiki/Q898365', 'display_name': 'Glycosylation', 'level': 2, 'score': 0.4494809}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4176639}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40599784}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3610565}, {'id': 'https://openalex.org/C138626823', 'wikidata': 'https://www.wikidata.org/wiki/Q916504', 'display_name': 'Chromosomal translocation', 'level': 3, 'score': 0.16630039}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.069595695}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002135', 'descriptor_name': 'Calcium-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002135', 'descriptor_name': 'Calcium-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037281', 'descriptor_name': 'Calnexin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037282', 'descriptor_name': 'Calreticulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011232', 'descriptor_name': 'Chemical Precipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000091342', 'descriptor_name': 'Endoplasmic Reticulum Chaperone BiP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006031', 'descriptor_name': 'Glycosylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008970', 'descriptor_name': 'Molecular Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011134', 'descriptor_name': 'Polysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011134', 'descriptor_name': 'Polysaccharides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012261', 'descriptor_name': 'Ribonucleoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012261', 'descriptor_name': 'Ribonucleoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012672', 'descriptor_name': 'Semliki forest virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.288.5464.331', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10764645', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.71, 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 14, 'referenced_works': ['https://openalex.org/W1520663094', 'https://openalex.org/W1607011919', 'https://openalex.org/W1607176255', 'https://openalex.org/W1977026532', 'https://openalex.org/W1981862236', 'https://openalex.org/W1999719904', 'https://openalex.org/W2011958996', 'https://openalex.org/W2034264764', 'https://openalex.org/W2068920418', 'https://openalex.org/W2089621623', 'https://openalex.org/W2107671070', 'https://openalex.org/W2115397055', 'https://openalex.org/W2121530802', 'https://openalex.org/W2137300408'], 'related_works': ['https://openalex.org/W67903361', 'https://openalex.org/W2086142693', 'https://openalex.org/W2037439168', 'https://openalex.org/W2032217040', 'https://openalex.org/W2025830314', 'https://openalex.org/W2006690805', 'https://openalex.org/W1992604276', 'https://openalex.org/W1989203765', 'https://openalex.org/W1986129246', 'https://openalex.org/W1967933898'], 'abstract_inverted_index': {'A': [0], 'variety': [1], 'of': [2, 11, 39, 55, 61, 89], 'molecular': [3, 28], 'chaperones': [4], 'and': [5, 31, 44, 73], 'folding': [6, 10, 38], 'enzymes': [7], 'assist': [8], 'the': [9, 16, 27, 34, 59, 65, 90], 'newly': [12], 'synthesized': [13], 'proteins': [14], 'in': [15, 49, 64], 'endoplasmic': [17], 'reticulum.': [18], 'Here': [19], 'we': [20], 'investigated': [21], 'why': [22], 'some': [23], 'glycoproteins': [24, 43], 'interact': [25], 'with': [26, 33, 71, 78], 'chaperone': [29, 56], 'BiP,': [30], 'others': [32], 'calnexin/calreticulin': [35], 'pathway.': [36], 'The': [37, 52], 'Semliki': [40], 'forest': [41], 'virus': [42], 'influenza': [45], 'hemagglutinin': [46], 'was': [47], 'studied': [48], 'living': [50], 'cells.': [51], 'initial': [53], 'choice': [54], 'depended': [57], 'on': [58], 'location': [60], 'N-linked': [62], 'glycans': [63, 82], 'growing': [66], 'nascent': [67], 'chain.': [68], 'Direct': [69], 'interaction': [70, 77], 'calnexin': [72], 'calreticulin': [74], 'without': [75], 'prior': [76], 'BiP': [79], 'occurred': [80], 'if': [81], 'were': [83], 'present': [84], 'within': [85], 'about': [86], '50': [87], 'residues': [88], "protein's": [91], 'NH': [92], '2': [93], '-terminus.': [94]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2086142693', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-09-16T21:23:21.618467', 'created_date': '2016-06-24'}