Abstract: Hippocratic Oath was first promulgated in 400 BC. Since then it became mandatory to take this oath for any medical profesional who practices medicine. The Oath envisaged all the important guidelines required to be possessed before the medicine is practiced. Recently there had been debates over the traditional oath and various revisionist versions were recommended. The enormous available literature compells us to think and revisit the status of orignal oath vis a vis the practice of medicine in 21st Century.This theme is a part of Dr. KL Wig Oration of National Academy of Medical Sciences, delivered at Ahmedabad in December 2005.