Title: Human, bronchial-mucus glycoproteins: a comparison between chemical properties and affinity for lectins
Abstract: This chapter discusses mucins secreted by mucosae or exocrine glands of human origin. It describes the evidence suggesting that human mucosal mucins form broad families of different glycoproteins stemming from two events, the expression of different mucin genes to form multiple apomucins. A wide variety of post-translational phenomena, mainly O-glycosylation, leading to carbohydrate chains with a vast microheterogeneity are also described in the chapter. In order to illustrate the differences between “mucosal mucins” and “mucin-like” substances, the present knowledge concerning episialin, a mucin-like glycoprotein, encoded by a gene called MUCl are summarized. The chapter discusses the biological significance of the diversity of mucosal mucins, as well as what is known about their pathophysiological modifications.
Publication Year: 1981
Publication Date: 1981-06-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 9
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