Publication Information

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2241, 2269, 2274, 2306, 2329, 2335, 2361, 2371, 2395, 2430, 2441, 2446, 2451, 2462, 2466, 2539, 2554, 2599, 2609, 2617, 2620, 2625, 2631, 2645, 2675, 2722, 2784, 2796, 2818, 2861, 3045, 3060, 3083, 3105, 3120, 3133, 3172, 3226, 3347, 3412, 3489, 3563, 3626, 3654, 3674, 3689, 3700, 3707, 3711, 3721, 3724, 3731, 3738, 3752, 3763, 3767, 3801, 3804, 3823, 3827, 3852, 3855, 3874, 3894, 3900, 3909, 3927, 3948, 3952, 3957, 3961, 3974, 3980, 3992, 3997, 4003, 4010, 4013, 4023, 4028, 4042, 4154, 4178, 4214, 4233, 4237, 4240, 4270, 4275, 4280, 4288, 4296, 4303, 4318, 4349, 4376, 4406, 4415, 4418, 4434, 4443, 4457, 4460, 4468, 4471], 'role': [18, 218], 'of': [19, 42, 79, 141, 149, 162, 192, 196, 219, 242, 279, 341, 349, 362, 392, 396, 473, 657, 726, 831, 937, 1030, 1249, 1255, 1270, 1274, 1288, 1304, 1307, 1311, 1540, 1565, 1570, 1573, 1695, 1789, 1798, 1802, 1816, 1868, 1881, 1889, 1900, 1932, 1979, 1998, 2056, 2089, 2095, 2101, 2219, 2222, 2233, 2247, 2261, 2280, 2296, 2334, 2420, 2465, 2553, 2585, 2633, 2718, 2780, 2786, 2795, 2803, 2825, 2843, 2849, 2916, 2949, 3030, 3075, 3078, 3093, 3187, 3194, 3203, 3215, 3248, 3252, 3261, 3284, 3303, 3329, 3335, 3393, 3448, 3453, 3500, 3503, 3565, 3583, 3591, 3607, 3640, 3656, 3706, 3720, 3723, 3790, 3833, 3835, 3854, 3861, 3873, 3899, 3951, 3969, 3973, 3996, 4009, 4027, 4036, 4156, 4177, 4216, 4239, 4246, 4284, 4290, 4353, 4402, 4420, 4449, 4473, 4480, 4492], 'this': [20, 220, 832, 1882, 1980, 2090, 2167, 2288, 2426, 3195, 3596, 3836], 'in': [22, 89, 101, 119, 122, 134, 155, 172, 222, 289, 301, 319, 322, 334, 355, 372, 433, 1252, 1384, 1527, 1534, 1800, 1864, 1884, 1905, 2002, 2066, 2192, 2461, 2616, 2662, 2685, 2715, 2767, 2777, 2822, 2875, 2885, 2908, 2930, 2967, 3014, 3178, 3231, 3445, 3524, 3687, 3703, 3718, 3762, 3808, 3831, 3914, 3947, 4047, 4153, 4163, 4172, 4221, 4236, 4258, 4262, 4279, 4306, 4348, 4417, 4451, 4470], 'interleukin': [23, 223, 400], '(IL)-1β': [24, 224], 'post-translational': [25, 225, 1286, 1389, 1599, 2283], 'processing,': [26, 226, 2284], 'we': [27, 227, 2169, 4000], 'have': [28, 228, 1264, 1992], 'generated': [29, 49, 229, 249, 3698, 4446], 'a': [30, 160, 184, 197, 230, 360, 384, 397, 428, 748, 951, 1018, 1069, 1519, 2087, 2171, 2245, 2277, 2405, 2413, 2545, 2549, 2614, 2634, 2768, 2787, 2850, 2909, 2913, 2946, 2984, 3015, 3099, 3183, 3204, 3259, 3449, 3507, 3525, 3542, 3580, 3888, 3933, 3970, 3986, 4006, 4160, 4259, 4292, 4354, 4421, 4474, 4493], 'P2X7R-deficient': [31, 173, 231, 373, 3844, 3868, 3928], 'mouse': [32, 232, 1529, 2307, 2364, 2396, 2407, 2431, 3712, 3755, 4140], 'line.P2X7R': [33, 233], '−/−': [34, 63, 84, 97, 138, 234, 263, 284, 297, 338, 2203, 2256, 4253, 4272, 4311, 4332, 4397, 4462], 'macrophages': [35, 151, 235, 351, 439, 1296, 1395, 1531, 2200, 2224, 2578, 2994, 3147, 3839, 3862, 3886, 4142, 4249, 4312, 4326, 4398, 4463, 4484], 'respond': [36, 236, 2239], 'to': [37, 55, 88, 113, 125, 146, 152, 157, 188, 237, 255, 288, 313, 325, 346, 352, 357, 388, 460, 470, 478, 585, 669, 746, 785, 824, 993, 997, 1060, 1079, 1386, 1525, 1536, 1603, 1805, 1927, 1983, 2106, 2174, 2194, 2206, 2225, 2230, 2238, 2240, 2250, 2264, 2305, 2389, 2394, 2403, 2411, 2429, 2457, 2548, 2597, 2742, 2865, 3041, 3109, 3181, 3239, 3343, 3408, 3435, 3488, 3612, 3728, 3750, 3967, 4033, 4049, 4185, 4189, 4232, 4248, 4302, 4453, 4467], 'lipopolysaccharide': [38, 91, 238, 291, 401, 1292], 'produce': [40, 240, 1532, 2226, 2251], 'levels': [41, 105, 241, 305, 1797], 'cyclooxygenase-2': [43, 243, 485], 'pro-IL-1β': [45, 58, 245, 258, 781, 947, 1024, 1238, 1533, 2227, 4385, 4450], 'comparable': [46, 246, 2064, 3904, 4447], 'with': [47, 247, 2212, 2566, 2630, 2783, 2943, 2977, 2983, 3022, 3066, 3150, 3290, 3300, 3364, 3568, 3579, 3588, 3603, 3637, 3730, 3766, 3893, 3905, 4149, 4336, 4340, 4485], 'those': [48, 248], 'wild-type': [51, 94, 114, 251, 294, 314, 2196, 2266, 3274, 3809, 3842, 3866, 3884, 4145, 4308, 4329, 4394, 4435, 4458, 4483], 'cells.': [52, 252], 'In': [53, 86, 253, 286, 723, 779, 1232, 2166, 3918, 3939, 4213, 4243, 4287], 'response': [54, 87, 156, 254, 287, 356, 1535, 4048, 4452], 'ATP,': [56, 256, 1397, 1566, 3401, 4217], 'however,': [57, 257, 1263, 1567, 1779], 'produced': [59, 259, 432, 709, 1067], 'P2X7R': [62, 83, 96, 137, 143, 180, 262, 283, 296, 337, 343, 380, 1795, 1870, 1902, 1924, 2000, 2058, 2181, 2202, 2275, 2308, 2336, 2397, 2432, 2467, 3690, 3740, 3753, 3805, 3828, 3895, 3911, 3953, 3962, 4029, 4252, 4271, 4310, 4319, 4331, 4396, 4461], 'cells': [64, 264, 421, 464, 675, 1032, 1526, 2237, 2492, 2535, 2563, 2646, 2723, 3046, 3062, 3348, 3359, 3413, 3437, 3686, 3736, 3798, 3916, 3924, 4344, 4359, 4365], 'not': [66, 132, 266, 332, 744, 783, 1258, 1281, 1523, 2217, 3780, 3812, 3877, 3931, 3965, 4020, 4256], 'externalized': [67, 267], 'or': [68, 268, 2573, 3243, 3402, 3615, 3622, 3628, 3843, 4351], 'activated': [69, 269, 436, 1233, 4148], 'caspase-1.': [71, 271], 'Nigericin,': [72, 272], 'alternate': [74, 274], 'secretion': [75, 275, 1520], 'stimulus,': [76, 276, 4356], 'promotes': [77, 116, 277, 316, 1302], 'release': [78, 153, 191, 278, 353, 391, 1273, 1310, 1543, 4491], '17-kDa': [80, 280, 732, 828, 1313, 4494], 'IL-1β': [81, 193, 281, 393, 660, 705, 1271, 1576, 1598, 2209, 2253, 3535, 3545, 3570, 3657, 4372, 4466, 4495], 'from': [82, 282, 455, 1786, 2201, 2360, 2445, 2455, 2560, 2639, 3273, 3538, 3548, 3793, 3841, 3865, 3883, 3923, 3926, 4144, 4175, 4251, 4269, 4328, 4375, 4388, 4392, 4433], 'vivo': [90, 166, 290, 366], 'injection,': [92, 292, 2598, 3598, 3630], 'both': [93, 293, 706, 944, 4307, 4393], 'animals': [98, 115, 298, 315, 2204, 2257, 2271, 2600, 2641, 3277, 3759, 3773, 3815, 3929, 4146, 4254, 4273, 4333], 'display': [99, 299, 735], 'increases': [100, 130, 300, 330, 4194], 'peritoneal': [102, 150, 302, 350, 1530, 2199, 2577, 2593, 2610, 2993, 3633, 3838, 3885, 4141], 'lavage': [103, 303], 'IL-6': [104, 127, 304, 327, 2262, 3662], 'but': [106, 306, 1542, 1918, 1986, 2228, 3811], 'no': [107, 307, 2188, 3397, 3941, 4218], 'detectable': [108, 308], 'IL-1.': [109, 309], 'Subsequent': [110, 310, 1562], 'ATP': [111, 311, 1596, 1799, 1814, 3242, 3610, 3627, 4050, 4152, 4247, 4487], 'injection': [112, 312, 1539, 1564], 'increase': [118, 318, 4162, 4171, 4220, 4261], 'IL-1,': [120, 320], 'which': [121, 321, 1595, 2324, 2459, 2613, 2817, 3104, 3688, 4358], 'turn': [123, 323, 1253], 'leads': [124, 145, 187, 324, 345, 387], 'additional': [126, 326, 1897], 'production;': [128, 328], 'similar': [129, 329], 'did': [131, 331, 3876, 3930, 3964, 4255], 'occur': [133, 333], 'ATP-treated,': [135, 335], 'LPS-primed': [136, 336], 'animals.': [139, 174, 339, 374], 'Absence': [140, 340], 'thus': [144, 344], 'inability': [148, 348, 2221, 2232, 2249], 'IL-1': [154, 164, 354, 364, 458, 586, 788, 938, 1388, 2282], 'ATP.': [158, 358, 2213, 4286], 'As': [159, 359, 1017, 2244], 'result': [161, 361, 4257], 'deficiency,in': [165, 365], 'cytokine': [167, 198, 367, 398, 833, 1277, 1314, 1545, 2235], 'signaling': [168, 368, 467, 737, 787], 'cascades': [169, 369, 468], 'are': [170, 370, 661, 707, 719, 948, 1257, 2182], 'impaired': [171, 371], 'Together': [175, 375], 'these': [176, 376, 665, 716, 3253, 3504, 3539], 'results': [177, 377, 3717, 4174], 'demonstrate': [178, 378, 1912, 2187, 2286, 3821], 'that': [179, 186, 379, 386, 476, 740, 1086, 1246, 1267, 1291, 1301, 1382, 1782, 1929, 1994, 2273, 2287, 2391, 2425, 2439, 3119, 3800, 3822, 3871, 3891, 3906, 3956, 3989, 4005, 4227, 4294, 4317, 4442, 4499], 'activation': [181, 381, 1248, 1303, 4051], 'can': [182, 382, 2104, 2290], 'provide': [183, 383], 'signal': [185, 385, 952], 'maturation': [189, 389], 'initiation': [195, 395], 'cascade.': [199, 399], 'embryonic': [404, 419], 'stem': [405], 'intraperitoneal': [406, 1537], 'cyclooxygenase-2,': [407], 'LDH,': [408], 'lactate': [409], 'dehydrogenase': [410], 'phosphospecific': [411], 'luminescence': [412], 'fetal': [413, 2666], 'bovine': [414], 'serum': [415, 2918, 3546], 'phosphate-buffered': [416], 'saline': [417], 'human': [418, 3910], 'kidney': [420], 'enzyme-linked': [422], 'immunoadsorbent': [423], 'assay': [424], 'Interleukin': [425], '(IL)1-1': [426], 'multipotential': [429], 'inflammatory': [430, 480, 2298], 'mediator': [431], 'abundance': [434, 1880], '(1Dinarello': [440], 'C.A.': [441, 547, 602, 1349, 1459, 1470, 1488, 1614, 1655], 'Int.': [442], 'Rev.': [443, 1006], 'Immunol.': [444, 1226, 1338, 1372, 1461, 1490, 1556, 1586, 1637, 1657, 2112], '1998;': [445, 523, 1686, 1769, 2482], '16:': [446, 2115], '457-499Crossref': [447], 'PubMed': [448, 505, 531, 554, 572, 613, 648, 699, 776, 815, 863, 929, 984, 1012, 1051, 1154, 1210, 1361, 1376, 1420, 1443, 1480, 1511, 1626, 1641, 1689, 1723, 1751, 1772, 1836, 1856, 1956, 2020, 2048, 2080, 2120, 2139, 2161, 2352, 2507, 2836, 4069, 4116, 4136, 4210], 'Scopus': [449, 506, 532, 555, 573, 614, 649, 864, 930, 985, 1013, 1052, 1155, 1362, 1377, 1421, 1444, 1512, 1627, 1642, 1724, 1752, 1773, 1973, 2021, 2049, 2081, 2121, 2140, 2162, 2353, 2485, 2508, 2837, 4086, 4117], '(682)': [450], 'Google': [451, 508, 534, 557, 575, 616, 651, 700, 777, 816, 866, 932, 987, 1015, 1054, 1157, 1211, 1230, 1342, 1364, 1379, 1423, 1446, 1465, 1481, 1494, 1514, 1560, 1590, 1629, 1644, 1661, 1690, 1726, 1754, 1775, 1837, 1857, 1957, 1975, 2023, 2051, 2083, 2123, 2142, 2164, 2355, 2487, 2510, 2839, 4070, 4088, 4119, 4137, 4211], 'Scholar).': [452, 576, 652, 701, 778, 933, 1016, 1231, 1380, 1515, 1561, 1591, 1691, 1776, 1976, 2084, 2165, 2356, 2488, 2532, 2840, 4138, 4212], 'When': [453, 4139], 'released': [454, 4464], 'producing': [456, 1031, 2236], 'cells,': [457], 'binds': [459], 'receptors': [461, 672, 1811, 1911, 2070], 'on': [462, 673, 2328, 2731, 2746, 3098, 3510], 'target': [463, 674], 'elicits': [466], 'leading': [469], 'up-regulation': [472], 'gene': [474, 579, 2309, 2337, 2444, 2468, 3691, 3725, 3963], 'products': [475], 'contribute': [477, 584], 'state': [481], 'including': [482], 'matrix': [483], 'metalloproteinases,': [484], '(Cox-2),': [486], 'IL-6,': [487], 'cellular': [489], 'adhesion': [490], 'molecules': [491, 4039, 4180], '(2Flannery': [492], 'C.R.': [493], 'Little': [494], 'C.B.': [495], 'Caterson': [496], 'B.': [497, 567, 621, 752, 791, 839, 957], 'Hughes': [498], 'C.E.': [499], 'Matrix': [500], 'Biol.': [501, 521, 691, 768, 807, 1008, 1202, 1351, 1472, 1616, 1741, 1828, 1848, 1948, 2038, 2076, 4061], '1999;': [502, 1353, 1618, 1970, 2158, 4083], '18:': [503], '225-237Crossref': [504], '(103)': [507], 'Scholar,': [509, 535, 558, 617, 1158, 1212, 1343, 1365, 1424, 1447, 1466, 1482, 1495, 1630, 1645, 1662, 1727, 1755, 1838, 1958, 2024, 2124, 2143, 4071, 4089, 4120], '3Guzn': [510], 'Z.': [511], 'Buckman': [512], 'S.Y.': [513], 'Miller': [514, 879, 1104, 1223, 1327], 'B.W.': [515], 'Springer': [516], 'L.D.': [517], 'Morrison': [518], 'A.R.': [519], 'J.': [520, 543, 545, 548, 677, 690, 767, 806, 886, 894, 1042, 1045, 1111, 1119, 1190, 1201, 1220, 1225, 1337, 1347, 1350, 1371, 1414, 1451, 1460, 1471, 1489, 1507, 1555, 1585, 1612, 1615, 1636, 1656, 1740, 1763, 1767, 1827, 1847, 1947, 1967, 2037, 2135, 2473, 4060, 4080, 4095, 4125, 4199], 'Chem.': [522, 692, 769, 808, 1203, 1352, 1473, 1617, 1742, 1829, 1849, 1949, 2039, 4062], '273:': [524], '28670-28676Abstract': [525], 'Full': [526, 528, 696, 773, 812, 1207, 1356, 1358, 1477, 1621, 1623, 1746, 1748, 1833, 1853, 1953, 2043, 2045, 2117, 4066], 'Text': [527, 529, 697, 774, 813, 1208, 1357, 1359, 1478, 1622, 1624, 1747, 1749, 1834, 1854, 1954, 2044, 2046, 2118, 4067], 'PDF': [530, 698, 775, 814, 1209, 1360, 1479, 1625, 1750, 1835, 1855, 1955, 2047, 2119, 4068], '(226)': [533], '4Allen': [536], 'M.': [537, 541, 918, 1143, 1409, 1501, 1672, 2126, 2147, 2494, 2502], 'Svensson': [538, 1485, 1650], 'L.': [539, 1486, 1651], 'Roach': [540], 'Hambor': [542], 'McNeish': [544], 'Gabel': [546, 1348, 1458, 1469, 1487, 1613, 1654], 'Exp.': [549, 1046], 'Med.': [550, 1047], '2000;': [551, 1373, 1638], '191:': [552], '859-869Crossref': [553], '(256)': [556], '5Bevilacqua': [559], 'M.P.': [560], 'Stengelin': [561], 'S.': [562, 608, 631, 681, 764, 803, 967, 1036, 1407, 1411, 1438, 1505, 1674, 1819, 2153, 2500, 4111, 4127, 4201], 'Gimbrone': [563], 'Jr.,': [564], 'M.A.': [565, 1334, 1428], 'Seed': [566], 'Science.': [568, 859, 1719, 2016, 2348], '1989;': [569], '243:': [570], '1160-1164Crossref': [571], '(1910)': [574], 'Two': [577, 3593], 'distinct': [578], 'products,': [580], 'IL-1α': [581, 658, 703], 'IL-1β,': [583], 'biological': [587], 'activity': [588], '(6Auron': [589], 'P.E.': [590], 'Webb': [591], 'A.C.': [592], 'Rosenwasser': [593], 'L.J.': [594], 'Mucci': [595], 'S.F.': [596], 'Rich': [597], 'A.': [598, 609, 623, 758, 797, 959, 1439, 1503, 1710, 1739, 1962, 1966, 2007, 2036, 2339, 2498, 2521, 4075, 4079, 4112], 'Wolff': [599], 'S.M.': [600, 882, 906, 1107, 1131, 1166, 1196], 'Dinarello': [601], 'Proc.': [603, 1433, 4106], 'Natl.': [604, 1434, 4107], 'Acad.': [605, 1435, 4108], 'Sci.': [606, 1436, 4109], 'U.': [607, 1437, 4110], '1984;': [610], '81:': [611], '7907-7911Crossref': [612], '(880)': [615], '7March': [618], 'C.J.': [619, 679, 837, 848, 955, 1653], 'Mosley': [620, 838, 956], 'Larsen': [622, 757, 796, 958], 'Cerretti': [624, 960], 'D.P.': [625, 835, 961], 'Braedt': [626, 962], 'G': [627, 963], 'Price': [628, 964], 'V.': [629, 965], 'Gillis': [630, 763, 802, 966], 'Henney': [632, 968], 'C.S.': [633, 969], 'Kroneeim': [634, 970], 'S.R.': [635, 850, 971], 'Grabstein': [636, 972], 'K.': [637, 683, 844, 856, 973, 1499, 2155, 2496], 'Conlon': [638, 761, 800, 974], 'P.J.': [639, 762, 801, 975], 'Hopp': [640, 976], 'T.P.': [641, 977], 'Cosman': [642, 759, 798, 978], 'D.': [643, 760, 799, 979, 1449, 1468, 1484, 1649, 1676, 2145], 'Nature.': [644, 925, 980, 1150, 2503, 2832], '1985;': [645, 981], '315:': [646, 982], '641-647Crossref': [647, 983], '(1333)': [650, 986], 'amino': [654], 'acid': [655], 'sequences': [656], '<30%': [662], 'identical': [663], 'yet': [664], 'two': [666, 935, 4444], 'polypeptides': [667, 996, 3944], 'bind': [668, 784], 'same': [671, 3490, 4276, 4304], '(8Slack': [676], 'McMahan': [678], 'Waugh': [680], 'Schooley': [682], 'Spriggs': [684], 'M.K.': [685], 'Sims': [686], 'J.E.': [687, 916, 1141], 'Dower': [688, 765, 804], 'S.K.': [689, 766, 805], '1993;': [693, 1204], '268:': [694, 1205], '2513-2524Abstract': [695], 'Human': [702], 'initially': [708], 'as': [710, 1068, 1873, 1934, 1936, 2086, 2292, 2370, 3115, 3258, 4041, 4405], '31-kDa': [711], 'procytokines': [712], 'containing': [713, 1886, 2588, 2664, 2912, 2945, 3032, 3307, 3332, 3368, 3396, 3737], 'amino-terminal': [714], 'extensions;': [715], 'extensions': [717], 'subsequently': [718, 2754, 3360], 'removed': [720], 'proteolysis.': [722], 'case': [725], 'pro-IL-1α,': [727], 'propolypeptide': [729, 1074], 'its': [731, 1874, 1906, 4031], 'cleavage': [733, 742, 819, 1254, 1306], 'product': [734, 1278, 2378, 2469], 'equivalent': [736, 3859, 4427], 'activity,': [738, 2092], 'indicating': [739, 4226], 'proteolytic': [741, 1268], 'necessary': [745, 823, 2278], 'generate': [747, 825, 1080, 2207, 2258, 3751], 'receptor-competent': [749], 'ligand': [750, 1875], '(9Mosley': [751, 790], 'Urdal': [753, 792], 'D.L.': [754, 793, 4103], 'Prickett': [755, 794], 'K.S.': [756, 795], '1987;': [770, 809, 1850, 1950, 2504, 4063], '262:': [771, 810, 1851, 1951, 4064], '2941-2944Abstract': [772, 811], 'contrast,': [780, 3919, 4244], 'does': [782], 'Scholar),': [817, 988], 'caspase-1': [821], 'mature': [827, 1089, 1276, 1575, 2208, 2252], 'signaling-competent': [829], 'form': [830, 4008], '(10Cerretti': [834], 'Kozlosky': [836], 'Nelson': [840], 'N.': [841], 'Van': [842], 'Ness': [843], 'Greenstreet': [845], 'T.A.': [846], 'March': [847], 'Kronheim': [849], 'Druck': [851], 'T.': [852], 'Cannizzaro': [853], 'L.A.': [854, 898, 1123, 1164, 1218], 'Huebner': [855], 'Black': [857], 'R.A.': [858, 920, 1145, 1198, 1716, 1737, 1964, 2013, 2034, 2072, 2345, 4077], '1992;': [860, 926, 1151, 1462, 2136], '256:': [861], '97-100Crossref': [862], '(1040)': [865], 'Scholar,11Thornberry': [867], 'N.A.': [868, 1093, 1182], 'Bull': [869, 1094], 'H.G': [870, 1095], 'Calaycay': [871, 1096, 1199], 'J.R.': [872, 884, 1097, 1109, 1184, 1200], 'Chapman': [873, 1098, 1187], 'K.T.': [874, 1099, 1188], 'Howard': [875, 1100, 1173], 'A.D.': [876, 1101, 1174, 1668, 1757, 1761, 2475], 'Kostura': [877, 1102, 1191, 1221], 'M.J.': [878, 924, 1103, 1149, 1192, 1222], 'D.K.': [880, 1105, 1160, 1224], 'Molineaux': [881, 1106, 1195], 'Weidner': [883, 1108, 1183], 'Aunins': [885, 1110], 'Elliston': [887, 1112], 'K.O.': [888, 1113], 'Ayala': [889, 1114, 1161], 'J.M.': [890, 1115, 1162, 1214, 1367, 1632], 'Casano': [891, 1116], 'F.J.': [892, 1117], 'Chin': [893, 1041, 1118, 1219], 'Ding': [895, 1120, 1169], 'G.J.-F.': [896, 1121, 1170], 'Egger': [897, 1122, 1163, 1217], 'Gaffney': [899, 1124, 1171], 'E.P.': [900, 1125, 1172], 'Limjuco': [901, 1039, 1126, 1193], 'G.': [902, 1040, 1127, 1194, 1413, 1664, 1670, 1718, 1735, 2015, 2032, 2347], 'Palyha': [903, 1128, 1175], 'O.C.': [904, 1129, 1176], 'Raju': [905, 1130, 1165], 'Rolando': [907, 1132, 1177], 'A.M.': [908, 1133, 1178], 'Salley': [909, 1134, 1179], 'J.P.': [910, 1135, 1180], 'Yamin': [911, 1136, 1167, 1215], 'T.-T.': [912, 1137, 1168, 1216], 'Lee': [913, 1138], 'T.D.': [914, 1139], 'Shively': [915, 1140], 'MacCross': [917, 1142], 'Mumford': [919, 1144, 1197], 'Schmidt': [921, 1043, 1146, 1412], 'J.A.': [922, 1044, 1147, 1844, 1944, 4057], 'Tocci': [923, 1148], '356:': [927, 1152], '768-774Crossref': [928, 1153], '(2298)': [931, 1156], 'forms': [936], 'share': [939], 'another': [940], 'very': [941], 'unusual': [942], 'attribute;': [943], 'pro-IL-1α': [945, 1022], 'synthesized': [949, 1021, 2311], 'without': [950], 'sequence': [953, 2333], '(7March': [954], 'peptide': [990, 3987], 'epitope': [991, 3988], 'required': [992], 'direct': [994], 'nascent': [995], 'endoplasmic': [999], 'reticulum': [1000], '(12Walter': [1001], 'P.': [1002, 2128, 2151], 'Johnson': [1003], 'A.E.': [1004], 'Annu.': [1005], 'Cell': [1007, 2075, 2710, 3441], '1994;': [1009, 1227, 1474, 1658, 4133, 4207], '10:': [1010], '87-119Crossref': [1011], '(729)': [1014], 'result,': [1019], 'newly': [1020], 'accumulate': [1025], 'within': [1026, 1242], 'cytoplasmic': [1028], 'compartment': [1029], '(13Singer': [1033], 'I.I.': [1034], 'Scott': [1035], 'Hall': [1037], 'G.L.': [1038], '1988;': [1048, 1830, 4113], '167:': [1049], '389-407Crossref': [1050], '(135)': [1053], 'Scholar)': [1055, 2511], 'rather': [1056, 2229], 'than': [1057, 2062], 'being': [1058], 'sequestered': [1059], 'secretory': [1062, 4355, 4422, 4475], 'apparatus.': [1063], 'Caspase-1': [1064], 'also': [1065], 'cytosol-localized': [1070], 'proenzyme;': [1071], '45-kDa': [1073], 'must': [1075], 'be': [1076, 1984, 3781], 'proteolytically': [1077], 'processed': [1078, 3114], '20-': [1082], '10-kDa': [1084], 'subunits': [1085], 'constitute': [1087], 'active': [1090], 'protease': [1091, 3495], '(11Thornberry': [1092], '14Miller': [1159], 'Thornberry': [1181], 'Williams': [1185], 'J.H.': [1186], 'Jackson': [1189], '18062-18069Abstract': [1206], '15Ayala': [1213], '153:': [1228, 1659], '2592-2599PubMed': [1229], 'macrophages,': [1236], 'therefore,': [1237], 'procaspase-1': [1240], 'co-exist': [1241], 'cytoplasm.': [1244], 'Mechanisms': [1245], 'control': [1247], 'procaspase-1,': [1250, 1305], 'pro-IL-1β,': [1256, 1308], 'well': [1259, 3043, 3235, 3283], 'understood.': [1260], 'Recent': [1261], 'studies,': [1262], 'provided': [1265], 'evidence': [1266], 'processing': [1269, 1287, 1390, 1600], 'extracellularly': [1279, 1546], 'do': [1280], 'proceed': [1282], 'constitutively.': [1283], 'Rather,': [1284], 'pro-IL-1': [1289], 'requires': [1290, 1796], '(LPS)-activated': [1293], 'and/or': [1295, 1394, 3438], 'encounter': [1297], 'external': [1299], 'stimulus': [1300, 1521, 4423, 4476], '(16Miller': [1315], 'B.E.': [1316], 'Krasney': [1317], 'P.A.': [1318], 'Gauvin': [1319], 'D.M.': [1320], 'Holbrook': [1321], 'K.B.': [1322], 'Koonz': [1323], 'D.J.': [1324], 'Abruzzese': [1325], 'R.V.': [1326], 'R.E.': [1328, 1332, 1345, 1610], 'Pagani': [1329], 'K.A.': [1330, 1426], 'Dolle': [1331], 'Ator': [1333], 'Gilman': [1335], 'S.C.': [1336, 1826, 1846, 1946, 4059, 4097, 4131, 4205], '1995;': [1339, 1508, 1557, 1587, 2114], '154:': [1340, 1558, 1588], '1331-1338PubMed': [1341], '17Laliberte': [1344], 'Eggler': [1346, 1611], '274:': [1354, 1619], '36944-36951Abstract': [1355, 1620], '(112)': [1363, 1628], '18Sanz': [1366, 1631], 'Di': [1368, 1633, 1820, 2131], 'Virgilio': [1369, 1634, 1821, 2110, 2132], 'F.': [1370, 1635, 1712, 1729, 1822, 2009, 2026, 2111, 2133, 2341], '164:': [1374, 1639], '4893-4898Crossref': [1375, 1640], '(237)': [1378, 1643], 'Stimuli': [1381], 'function': [1383, 3260], 'vitro': [1385], 'promote': [1387], 'LPS-activated': [1392, 2198, 4481], 'include': [1396], 'nigericin,': [1398], 'cytolytic': [1399], 'T-cells,': [1400], 'bacterial': [1401], 'toxins,': [1402], 'hypotonic': [1404], 'stress': [1405], '(19Bhakdi': [1406], 'Muhly': [1408], 'Korom': [1410], 'Clin.': [1415], 'Invest.': [1416], '1990;': [1417], '85:': [1418, 4114], '1746-1753Crossref': [1419], '(115)': [1422], '20Hogquist': [1425], 'Nett': [1427], 'Unanue': [1429], 'E.R.': [1430], 'Chaplin': [1431], 'D.D.': [1432], '1991;': [1440], '88:': [1441], '8485-8489Crossref': [1442], '(448)': [1445], '21Perregaux': [1448], 'Barberia': [1450], 'Lanzetti': [1452], 'A.J.': [1453], 'Geoghegan': [1454], 'K.F.': [1455], 'Carty': [1456], 'T.J.': [1457], '149:': [1463], '1294-1303PubMed': [1464], '22Perregaux': [1467], '269:': [1475], '15195-15203Abstract': [1476], '23Perregaux': [1483], '1996;': [1491, 1720, 2017, 2077, 2349], '157:': [1492], '57-64PubMed': [1493], '24Walev': [1496], 'I.': [1497, 4129, 4203], 'Reske': [1498], 'Palmer': [1500], 'Valeva': [1502], 'Bhakdi': [1504], 'EMBO': [1506], '14:': [1509], '1607-1614Crossref': [1510], '(248)': [1513], 'This': [1516, 2214, 2374, 4170, 4315, 4439], 'requirement': [1517, 1862], 'for': [1518, 1871, 2099, 2748, 2761, 2801, 2902, 2940, 3052, 3088, 3294, 3354, 3419, 3432, 3521, 3653, 3803, 3851], 'restricted': [1524], 'culture;': [1528], '(ip)': [1538], 'LPS,': [1541, 3319, 3382], 'little': [1544], '(25Griffiths': [1547, 1577], 'R.J.': [1548, 1578], 'Stam': [1549, 1579], 'E.J.': [1550, 1580], 'Downs': [1551, 1581], 'J.T.': [1552, 1582], 'Otterness': [1553, 1583, 3551], 'I.G.': [1554, 1584], '2821-2828PubMed': [1559, 1589], 'ip': [1563, 3587, 3602], 'stimulates': [1568], 'generation': [1569, 3765], 'large': [1571, 1935, 4037], 'quantities': [1572, 2260], 'extracellular': [1574, 4157, 4285, 4486], 'mechanism': [1593], 'activates': [1597], 'believed': [1602], 'involve': [1604], 'purinergic': [1607], '(17Laliberte': [1609], '26Laliberte': [1646], 'R.': [1647, 1680], 'Perregaux': [1648], 'Pazoles': [1652], '2168-2179PubMed': [1660], '27Buell': [1663], 'Chessell': [1665, 1758], 'I.P.': [1666, 1759, 2471], 'Michel': [1667], 'Collo': [1669, 1734, 2031], 'Salazzo': [1671], 'Herren': [1673], 'Gretener': [1675], 'Grahames': [1677], 'C.': [1678, 1733, 1960, 2030, 4073, 4101], 'Kaur': [1679], 'Kosco-Vilbois': [1681], 'M.H.': [1682], 'Humphrey': [1683, 1764, 2478], 'P.P.A.': [1684, 1765, 2479], 'Blood.': [1685, 4132, 4206], '92:': [1687], '3521-3528Crossref': [1688], 'Like': [1692], 'other': [1693, 1787, 1809, 2068], 'members': [1694, 1788], 'P2X': [1697, 1810, 1910, 2069], 'family,': [1699], '(28Surprenant': [1709, 2006, 2338], 'Rassendren': [1711, 2008, 2340], 'Kawashima': [1713, 2010, 2342], 'E.': [1714, 2011, 2343], 'North': [1715, 1736, 1963, 2012, 2033, 2344, 4076], 'Buell': [1717, 1730, 2014, 2027, 2346], '272:': [1721, 1744, 2018, 2041, 2350], '735-738Crossref': [1722, 2019, 2351], '(1547)': [1725, 2022, 2354], '29Rassendren': [1728, 2025], 'G.N.': [1731, 2028], 'Virginio': [1732, 2029], 'Surprenant': [1738, 1965, 2035, 4078], '1997;': [1743, 2040], '5482-5486Abstract': [1745, 2042], '(452)': [1753, 2050], '30Michel': [1756], 'Hibell': [1760, 2474], 'Simon': [1762, 2472], 'Br.': [1766], 'Pharmacol.': [1768], '125:': [1770], '1194-1201Crossref': [1771], '(38)': [1774], 'P2X7R,': [1778], 'demonstrates': [1780, 4316], 'attributes': [1781], 'clearly': [1783], 'distinguish': [1784], 'it': [1785, 2392], 'family.': [1791], 'For': [1792, 2989], 'example,': [1793], 'excess': [1801], '1': [1803, 2696, 2699, 2701, 2705, 2941, 3028, 3188, 3291, 3317, 3355, 3380, 3446, 3469, 3472, 3476, 3480, 3589, 3817], 'mm': [1804, 2689, 2694, 2697, 2888, 2893, 3154, 3161, 3164, 3167, 3241, 3378, 3385, 3400, 3458, 3461, 3466, 3473, 3609, 4151], 'achieve': [1806, 3182], 'activation,': [1807], 'whereas': [1808], 'activate': [1812], 'at': [1813, 2733, 2764, 2872, 2905, 3011, 3049, 3263, 3351, 3416, 3518, 3681, 3991], 'concentrations': [1815, 1888, 3497], '≤100': [1817], 'μm(31Greenberg': [1818], 'Steinberg': [1823, 2129, 4092], 'T.H.': [1824, 1840, 1940, 2130, 4053, 4093], 'Silverstein': [1825, 1845, 1945, 4058, 4096, 4130, 4204], '263:': [1831], '10337-10343Abstract': [1832], '32Steinberg': [1839], 'Newman': [1841, 1941, 4054], 'A.S.': [1842, 1942, 4055], 'Swanson': [1843, 1943, 4056], '8884-8888Abstract': [1852, 1952, 4065], 'Scholar);': [1858, 2052], 'higher': [1860], 'concentration': [1861, 3186], 'reflects,': [1863], 'part,': [1865], 'preference': [1867], 'ATP4−': [1872], 'relatively': [1878], 'low': [1879, 4277], 'species': [1883, 3572], 'media': [1885, 4361], 'physiological': [1887], 'divalent': [1890], 'cations': [1891], '(e.g.': [1892], 'Ca2+': [1893], 'Mg2+).': [1895], 'An': [1896, 3858], 'unique': [1898], 'feature': [1899], 'found': [1904], 'conductance': [1907], 'properties.': [1908], 'All': [1909, 3667], 'non-selective': [1913], 'channel-like': [1914], 'properties': [1915], 'following': [1916], 'ligation,': [1917], 'channels': [1920], 'formed': [1921], 'rapidly': [1925], 'transform': [1926], 'pores': [1928], 'allow': [1930], 'passage': [1931], 'solutes': [1933], '900': [1937], 'Da': [1938], '(32Steinberg': [1939, 4052], '33Virginio': [1959, 4072], 'Mackenzie': [1961, 4074], 'Physiol.': [1968, 4081], '(Lond.).': [1969, 4082], '519:': [1971, 4084], '335-346Crossref': [1972, 4085], '(330)': [1974, 4087], 'Molecular': [1977, 2881, 2987], 'details': [1978], 'transformation': [1981], 'remain': [1982], 'described,': [1985], 'domain': [1987, 1997, 2055, 2464], 'swapping': [1988], 'deletion': [1990], 'experiments': [1991], 'suggested': [1993], 'carboxyl-terminal': [1996, 2054, 2463], 'participates': [2001], 'pore': [2003], 'complex': [2004], 'formation': [2005, 4489], 'significantly': [2060], 'longer': [2061], 'domains': [2065], '(34North': [2071], 'Curr.': [2073], 'Opin.': [2074], '8:': [2078], '474-483Crossref': [2079], '(138)': [2082], 'Possibly': [2085], 'consequence': [2088, 2246], 'pore-like': [2091], 'continuous': [2093], 'ligation': [2094], 'times': [2100], '>15': [2102], 'min': [2103, 2730, 2763, 2935, 2972, 3296, 3523, 3621, 3624], 'lead': [2105, 3966], 'cell': [2107, 2366, 2655, 2670, 2680, 2738, 2752, 3174, 3185, 3196, 3439, 4379, 4389], 'death': [2108], '(35Di': [2109], 'Today.': [2113], '524-528Abstract': [2116], '(352)': [2122], '36Murgia': [2125], 'Pizzo': [2127], 'Biochem.': [2134], '288:': [2137], '897-901Crossref': [2138], '(89)': [2141], '37Ferrari': [2144], 'Los': [2146], 'Bauer': [2148], 'M.K.A.': [2149], 'Vandenabeele': [2150], 'Wesselborg': [2152], 'Schulze-Osthoff': [2154], 'FEBS': [2156, 2480], 'Lett.': [2157, 2481], '447:': [2159], '71-75Crossref': [2160], '(244)': [2163], 'study': [2168], 'employ': [2170], 'genetic': [2172], 'approach': [2173], 'inactivate': [2175], 'P2X7R.': [2177], 'Mice': [2178, 3617], 'lacking': [2179, 4012], 'healthy': [2183], 'fertile': [2185, 3777], 'overt': [2189], 'phenotype.': [2190], 'However,': [2191, 3978], 'contrast': [2193], 'their': [2195, 2248, 2265, 4183, 4191], 'counterparts,': [2197], 'fail': [2205], 'when': [2210, 3912, 4187], 'challenged': [2211], 'defect': [2215], 'because': [2218, 3979], 'purinoceptor': [2242], 'agonist.': [2243], 'post-ATP': [2254], 'challenge,P2X7R': [2255], 'reduced': [2259], 'relative': [2263], 'controls.': [2267], 'Therefore,': [2268], 'knockout': [2270, 3813, 4437], 'establish': [2272], 'component': [2279], 'ATP-induced': [2281], 'serve': [2291], 'important': [2294], 'element': [2295], 'cascade': [2299], 'mechanism.': [2300], 'A': [2301, 2434, 2669, 4025], 'cDNA': [2302, 2332], 'probe': [2303, 2400, 2546], 'specific': [2304, 2547], 'was': [2310, 2368, 2379, 2385, 2401, 2437, 2606, 2622, 2628, 2672, 2775, 2798, 3039, 3124, 3136, 3176, 3199, 3224, 3229, 3237, 3256, 3341, 3406, 3536, 3573, 3635, 3692, 3806, 3983, 4166, 4224, 4373, 4386, 4424], 'reverse': [2313], 'transcription-polymerase': [2314], 'chain': [2315, 2376], 'reaction': [2316, 2377], 'using': [2317, 2517, 2544, 3541, 3699], 'primers': [2318], 'P2X7-F1': [2319], '(5′-CGGCGTGCGTTTTGACATCCT-3′)': [2320], 'P2X7-R2': [2322], '(5′-AGGGCCCTGCGGTTCTC-3′),': [2323], 'were': [2325, 2512, 2542, 2564, 2579, 2601, 2642, 2647, 2657, 2682, 2713, 2724, 2740, 2755, 2812, 2820, 2845, 2863, 2869, 2900, 2928, 2965, 2999, 3019, 3047, 3058, 3063, 3071, 3086, 3096, 3107, 3113, 3148, 3288, 3349, 3361, 3414, 3423, 3443, 3486, 3514, 3532, 3558, 3585, 3600, 3618, 3644, 3647, 3671, 3697, 3742, 3760, 3774, 3846, 3863, 3945, 4147, 4334, 4346, 4362, 4366], 'designed': [2326], 'based': [2327], 'published': [2330], 'rat': [2331], 'Total': [2357], 'RNA': [2358, 3791], 'isolated': [2359, 3792, 3882, 3925, 4143, 4250, 4268, 4327], 'J774': [2362], 'A.1': [2363], 'monocyte/macrophage': [2365], 'line': [2367], 'used': [2369, 2402, 3749], 'template': [2372], 'RNA.': [2373], 'polymerase': [2375], '401': [2380], 'base': [2381], 'pairs': [2382], 'long': [2383], 'cloned': [2386], 'sequenced': [2388], 'verify': [2390], 'corresponded': [2393, 2428], 'gene.': [2398, 2433, 3734], 'screen': [2404], '129/Sv': [2406], 'genomic': [2408, 2416, 2550], 'library': [2409], 'isolate': [2412], 'single': [2414], 'positive': [2415], 'clone.': [2417], 'Sequence': [2418], 'analysis': [2419, 2802, 3747, 3789, 3850], 'BamHI': [2421], 'subcloned': [2422], 'fragments': [2423], 'confirmed': [2424], 'clone': [2427], 'targeting': [2435, 3708], 'vector': [2436, 3709], 'constructed': [2438], 'inserted': [2440], 'neomycin': [2442, 3732], 'resistance': [2443, 3733], 'pJNS2': [2447], 'plasmid': [2448], 'after': [2450, 2612, 2816, 2859, 3103, 3595, 3625, 4357, 4414], 'Arg505': [2452], 'codon,': [2453], 'deleting': [2454], 'Cys506': [2456, 3727], 'Pro532,': [2458], '(38Chessell': [2470], 'Barnard': [2476], 'E.A.': [2477], '439:': [2483], '260-300Crossref': [2484], '(134)': [2486], '129/Ola-derived': [2489], 'E14Tg2a': [2490], 'ES': [2491, 2534, 2562, 3685, 3735], '(39Hooper': [2493], 'Hardy': [2495], 'Handyside': [2497], 'Hunter': [2499], 'Monk': [2501], '326:': [2505], '292-295Crossref': [2506], '(968)': [2509], 'grown,': [2513], 'transformed,': [2514], 'screened': [2516], 'standard': [2518], 'methods': [2519], '(40Mohn': [2520], 'Koller': [2522], 'B.H.': [2523], 'DNA': [2524], 'Cloning': [2525], '4.': [2526], 'Oxford': [2527], 'University': [2528], 'Press,': [2529], 'New': [2530], 'York1995Google': [2531], 'Targeted': [2533], 'mice': [2537, 2558, 3584, 3599, 3670, 3845], 'carrying': [2538], 'mutant': [2540, 3739], 'allele': [2541, 3741], 'identified': [2543, 3743, 3782], 'region': [2551, 3722], 'upstream': [2552], 'targeted': [2555, 2561], 'locus.': [2556], 'Chimeric': [2557], 'derived': [2559, 4391], 'mated': [2565], 'B6D2': [2567], '(C57': [2568], 'BL/6': [2569], '×': [2570, 2652, 3005, 3189, 3279, 3430], 'DBA/2': [2571], 'F1)': [2572], 'C57BL/6': [2574], 'mice.': [2575], 'Mouse': [2576, 3684], 'harvested': [2580, 3424, 4363], 'injecting': [2582], '5': [2583, 2934, 2971, 3160, 3240, 3399, 3433, 4150], 'ml': [2584, 2717, 2779, 3029, 3302, 3328, 3392, 3447, 3606, 3639], 'RPMI': [2586, 2663, 3305, 3365], 'medium': [2587, 2605, 3031, 3152, 3180, 3306, 3331, 3367, 3395, 3484, 4377, 4469], '5%': [2589, 2665, 2997, 3016, 3024], 'FBS': [2590, 3025], 'into': [2591, 2847, 3001, 3201, 3710, 3826, 3960], 'each': [2592, 3042, 3094, 3344, 3409, 3632], 'cavity;': [2594], 'immediately': [2595], 'prior': [2596], 'euthanized.': [2602], 'injected': [2604, 2626, 3586, 3601], 'dispersed': [2607], 'throughout': [2608], 'cavity,': [2611], 'hole': [2615], 'skin': [2618], 'covering': [2619], 'peritoneum': [2621], 'introduced': [2623, 3825, 3959], 'fluid': [2627], 'recovered': [2629, 2756, 3533, 3761, 3864, 4374, 4387, 4404], 'aid': [2632, 2785], 'transfer': [2635], 'pipette.': [2636], 'Lavage': [2637], 'fluids': [2638], 'multiple': [2640], 'pooled': [2643], 'collected': [2648, 2813, 3648], 'centrifugation': [2650, 2661, 2758, 2815, 3428, 3517], '(300': [2651], 'g).': [2653], 'These': [2654, 2867, 3111, 3357, 4342], 'pellets': [2656, 2681, 2711, 2819], 'washed': [2658, 2683, 2929, 2966, 3020, 3064, 3149], 'twice': [2659, 3021, 3065, 3363], 'calf': [2667], 'serum.': [2668], 'count': [2671], 'performed': [2673], 'before': [2674], 'final': [2676, 3184, 3491], 'wash.': [2677], 'Peritoneal': [2678, 3146, 4325], 'macrophage': [2679, 3879, 3920], 'once': [2684], 'cavitation': [2686, 2719, 2728, 2781], 'buffer': [2687, 2782, 2829, 3451], '(25': [2688], 'Hepes,': [2690, 3155, 3386, 3462], 'pH': [2691, 2890, 3156, 3323, 3387, 3463, 3613], '7,': [2692, 3464], '30': [2693, 2749, 2762, 3420, 3522, 3608, 3620], 'NaCl,': [2695, 2894, 3459], 'EDTA,': [2698], 'mmdithiothreitol,': [2700], 'μg/ml': [2702, 2706, 3292, 3312, 3318, 3373, 3381, 3477, 3481], 'leupeptin,': [2703], 'pepstatin)': [2707], 'centrifugation.': [2709], 'then': [2712, 2899, 2938, 2975, 3027, 3057, 3069, 3198, 3236, 3298, 3340, 3405, 4345], 'suspended': [2714, 2776, 2821, 3177, 3444], '2.5': [2716], 'buffer,': [2720], 'disrupted': [2725, 3693], 'nitrogen': [2727], '(15': [2729, 3153], 'ice': [2732, 2747], '750': [2734], 'psi).': [2735], 'resulting': [2737, 3084, 3173, 3530], 'lysates': [2739], 'adjusted': [2741, 3238, 3487], '0.1%': [2743, 2895], 'saponin,': [2744, 4291], 'incubated': [2745, 2901, 2939, 3009, 3048], 'min,': [2750], 'membranes': [2753, 2810, 3921], '(50,000': [2759], 'rpm': [2760, 3520], '4': [2765, 2873, 3053], '°C': [2766, 2874, 3013, 3051, 3353, 3418], 'Beckman': [2769], 'Ti70': [2770], 'rotor).': [2771], 'membrane': [2773, 4235], 'pellet': [2774, 3175], '2': [2778, 2903, 3216, 3301, 3377], 'glass': [2788], 'tube-teflon': [2789], 'pestle': [2790], 'homogenizer,': [2791], 'aliquot': [2794], 'suspension': [2797, 3197], 'set': [2799], 'aside': [2800], 'total': [2804], 'protein': [2805, 2844], '(Pierce,': [2806], 'Rockford,': [2807], 'IL).': [2808], 'again': [2811], '100': [2823, 3033, 3308, 3311, 3369, 3372], 'μl': [2824, 3077, 3092, 3193, 3214], '2×': [2826, 3079], 'Laemmli': [2827, 3080], 'sample': [2828, 3081, 3095], '(41Laemmli': [2830], 'U.K.': [2831], '1970;': [2833], '227:': [2834], '680-685Crossref': [2835], '(218082)': [2838], '40': [2841], 'μg': [2842, 3590], 'loaded': [2846], 'wells': [2848, 3202], '4–20%': [2851, 3100], 'Tris-glycine': [2852, 3101], 'gel': [2853], '(Novex,': [2854], 'San': [2855], 'Diego,': [2856], 'CA),': [2857], 'separation': [2860], 'proteins': [2862, 3106], 'transferred': [2864, 3108], 'nitrocellulose.': [2866, 3110], 'blots': [2868, 3112], 'blocked': [2870], 'overnight': [2871, 3010], '1×': [2876, 2923, 2960], 'Western': [2877, 2924, 2961, 2991, 3849, 3949], 'blocking': [2878, 2925, 2962], 'reagent': [2879], '(Roche': [2880, 2986], 'Biochemicals,': [2882], 'Indianapolis,': [2883], 'IN)': [2884], 'TBS-T': [2886, 2910, 2931, 2944, 2968], '(10': [2887], 'Tris,': [2889], '8,': [2891], '150': [2892, 3457], 'Tween': [2896], '20).': [2897], 'Blots': [2898, 2927, 2964], 'h': [2904, 2942], 'room': [2906], 'temperature': [2907], 'solution': [2911], '1:200': [2914], 'dilution': [2915, 2948], 'anti-P2X7R': [2917], '(Alomone,': [2919], 'Jerusalem,': [2920], 'Israel)': [2921], 'reagent.': [2926, 2963], '(three': [2932, 2969], 'rinses,': [2933, 2970], 'each)': [2936], '1:2000': [2947, 3130, 3144], 'horseradish': [2950, 3137], 'peroxidase-conjugated': [2951, 3138], 'anti-rabbit': [2952], 'IgG': [2953], '(New': [2954, 3141], 'England': [2955, 3142], 'BioLabs,': [2956, 3143], 'Beverly,': [2957], 'MA)': [2958], 'each),': [2973], 'developed': [2976], 'Super': [2978], 'Signal': [2979], '(Pierce)': [2980], 'imaged': [2982], 'Lumi-imager': [2985], 'Biochemicals).': [2988], 'Cox-2': [2990], 'analysis,': [2992], '(in': [2995], 'RPMI,': [2996, 3023], 'FBS)': [2998], 'seeded': [3000, 3281], '6-well': [3002, 3285], 'plates': [3003], '(1': [3004], '106': [3006, 3190], 'cells/well)': [3007], '37': [3012, 3050, 3264, 3352, 3417], 'CO2environment.': [3017], 'Cells': [3018], 'ng/ml': [3034], 'LPS': [3035, 3293, 3597, 4337, 4454], '(type': [3036], '055:B5,': [3037], 'Sigma)': [3038], 'added': [3040, 3342, 3407], 'h.': [3054, 3356], 'Medium': [3055], 'supernatants': [3056, 3531, 3646], 'discarded,': [3059], 'adherent': [3061], 'PBS,': [3067], 'they': [3070], 'solubilized': [3072, 4367], 'addition': [3074, 3247, 3499, 4245], '200': [3076], 'buffer;': [3082], 'samples': [3085, 3485, 3513, 3540], 'boiled': [3087], '3': [3089, 3638], 'min.': [3090, 3421], '20': [3091, 3403], 'fractionated': [3097, 3559], 'gel,': [3102], 'described': [3116], 'above': [3117], 'except': [3118], 'primary': [3121], 'antibody': [3122, 3135, 3981], 'employed': [3123, 3982], 'anti-prostaglandin': [3125], 'synthase-2': [3126], '(Oxford,': [3127], 'Oxford,': [3128], 'MI;': [3129], 'dilution)': [3131], 'secondary': [3134], 'rabbit': [3139], 'anti-IgG': [3140], 'dilution).': [3145], 'isotonic': [3151, 3179, 3232], '7.2,': [3157], '135': [3158], 'mmNaCl,': [3159], 'KCl,': [3162], '1.8': [3163], 'CaCl2,': [3165], '0.8': [3166], 'MgCl2)': [3168], 'centrifugation,': [3170], 'cells/ml.': [3191], '50': [3192, 3213], 'placed': [3200], 'Microfluor': [3205], '“B”': [3206], 'U-bottom': [3207], 'plate': [3208], '(Dynatech,': [3209], 'Chantilly,': [3210], 'VA),': [3211], 'μm': [3217], 'YoPro': [3218, 4045, 4158, 4228, 4299, 4322], 'Yellow': [3219, 4046, 4229, 4300, 4323], '(Molecular': [3220], 'Probes,': [3221], 'Eugene,': [3222], 'OR)': [3223], 'introduced;': [3225], 'fluorescent': [3227, 4043], 'dye': [3228, 4044, 4179], 'dissolved': [3230], 'medium.': [3233], 'Each': [3234], '0.0075%': [3244], 'saponin': [3245], 'concentrated': [3249, 3501], 'stock': [3250], 'solutions': [3251], 'agents.': [3254], 'Fluorescence': [3255], 'monitored': [3257], 'time': [3262], '°C;': [3265], 'excitation,': [3266], '450': [3267], 'nm;': [3268], 'emission,': [3269], '530': [3270], 'nm.': [3271], 'Macrophages': [3272, 4267], 'P2X7R−/−': [3276], '(2': [3278], '106cells': [3280], 'per': [3282], 'cluster': [3286], 'plates)': [3287], 'stimulated': [3289, 4335], '75': [3295], 'rinsed': [3299, 3362], 'methionine-free': [3304], 'units/ml': [3309, 3370], 'penicillin,': [3310, 3371], 'streptomycin,': [3313, 3374], '1%': [3314, 3375, 3454], 'dialyzed': [3315], 'FBS,': [3316, 3376], '25': [3321, 3384, 3460], 'mmHepes,': [3322], '7.3': [3324, 3388], '(pulse': [3325], 'medium).': [3326, 3390], 'One': [3327, 3391], 'pulse': [3330], '83': [3333], 'μCi/ml': [3334], '[35S]methionine': [3336, 4403], '(Amersham': [3337, 3658], 'Pharmacia': [3338, 3659], 'Biotech)': [3339, 3660], 'well,': [3345, 3410], 'labeled': [3350, 3358, 4339], '1640': [3366], 'glutamine,': [3379], '(chase': [3389], 'chase': [3394, 4416], 'effector,': [3398], 'μmnigericin': [3404], 'chased': [3415, 4347], 'Media': [3422], 'clarified': [3426, 3515], '(6000': [3429], 'g': [3431], 'min)': [3434], 'remove': [3436], 'debris.': [3440], 'monolayers': [3442], 'lysis': [3450], 'composed': [3452], 'Triton': [3455, 3492], 'X-100,': [3456], '0.1': [3465], 'phenylmethylsulfonyl': [3467], 'fluoride,': [3468], 'mg/ml': [3470], 'ovalbumin,': [3471], 'iodoacetic': [3474], 'acid,': [3475], 'pepstatin,': [3478], 'leupeptin.': [3482], 'Clarified': [3483], 'X-100': [3493], 'inhibitor': [3496], 'stocks': [3502], 'reagents.': [3505], 'After': [3506], '30-min': [3508], 'incubation': [3509], 'ice,': [3511], 'all': [3512], '45,000': [3519], 'TLA-45': [3526], 'rotor': [3527], '(Beckman).': [3528], 'immunoprecipitated': [3537], 'goat': [3543], 'anti-murine': [3544], 'obtained': [3547, 3840], 'Dr.': [3549], 'Ivan': [3550], '(Pfizer': [3552], 'Central': [3553], 'Reseach,': [3554], 'Groton,': [3555], 'CT).': [3556], 'Immunoprecipitates': [3557], 'SDS-gel': [3561], 'electrophoresis;': [3562], 'quantity': [3564], 'radioactivity': [3566], 'associated': [3567], 'individual': [3569], 'polypeptide': [3571, 3890, 3902, 3936, 4409], 'determined': [3574], 'scanning': [3576], 'dried': [3577], 'gels': [3578], 'phosphorimager.': [3581], 'Groups': [3582], 'LPS.': [3592], 'hours': [3594], 'either': [3604], '0.5': [3605], '(adjusted': [3611], '7)': [3614], 'PBS.': [3616], 'euthanized': [3619], '120': [3623], 'PBS': [3629], 'cavity': [3634], 'lavaged': [3636], 'media.': [3641], 'Individual': [3642], 'lavages': [3643], 'centrifuged,': [3645], 'tested': [3650], 'ELISA': [3652], 'presence': [3655, 3853, 4155, 4283, 4289, 4352], '(Endogen,': [3663], 'Inc.': [3664, 3683], 'Woburn,': [3665], 'MA).': [3666], 'procedures': [3668], 'involving': [3669], 'approved': [3672], 'Institutional': [3675], 'Animal': [3676], 'Care': [3677], 'Use': [3679], 'Committee': [3680], 'Pfizer': [3682], 'homologous': [3695, 3715], 'recombination': [3696, 3716], 'scheme': [3701], 'shown': [3702], 'Fig.1.': [3704], 'Integration': [3705], 'genome': [3713], 'replacement': [3719], 'encoding': [3726], 'Pro532': [3729], 'Southern': [3745], 'blot': [3746, 3950], 'Δ506–532': [3754], 'line.': [3756], 'Homozygous': [3757], 'null': [3758], 'F2': [3764], 'expected': [3768], 'Mendelian': [3769], 'frequencies.P2X7R': [3770], 'Δ506–532(P2X7R': [3771], '−/−)': [3772], 'viable': [3775], 'could': [3779], 'among': [3783], 'littermates': [3784], 'observation': [3786], 'alone.': [3787], 'Northern': [3788], 'cultured': [3794], 'bone': [3795], 'marrow': [3796], 'mast': [3797], 'signified': [3799], 'transcript': [3802], 'present': [3807, 4018], '(+/+)': [3810], '(−/−)': [3814], '(Fig.': [3816, 3937, 3976, 4168, 4265, 4313, 4477, 4496], 'C).': [3818], 'further': [3820], 'mutation': [3824, 3958], 'locus': [3829], 'resulted': [3830], 'loss': [3832], 'expression': [3834, 3968], 'gene,': [3837], 'compared': [3847], 'polypeptide.': [3857], 'number': [3860], 'animals,': [3869], 'suggesting': [3870, 3955], 'absence': [3872, 4215, 4238, 4281, 4350, 4419, 4472], 'alter': [3878], 'development.': [3880], 'Membranes': [3881], 'contained': [3887], '76-kDa': [3889], 'cross-reacted': [3892], 'antiserum.': [3896], 'size': [3898], 'murine': [3901], 'displayed': [3907], 'overexpressed': [3913], 'HEK293': [3915], '(Fig.2).': [3917], 'prepared': [3922, 3984], 'contain': [3932], 'similarly': [3934], 'sized': [3935], '2).': [3938, 3977], 'addition,': [3940], 'smaller': [3942], 'cross-reacting': [3943], 'observed': [3946, 4167], '−/−cells,': [3954], 'truncated': [3971, 4007], 'version': [3972], 'against': [3985], 'resides': [3990], 'extreme': [3993], 'carboxyl': [3994, 4015], 'terminus': [3995, 4016], 'polypeptide,': [3999], 'cannot': [4001], 'exclude': [4002], 'possibility': [4004], 'entire': [4014], 'detected': [4021], 'analysis.': [4024], 'hallmark': [4026], 'ability': [4032], 'facilitate': [4034], 'translocation': [4035], 'organic': [4038], 'such': [4040], '42Buisman': [4090], 'H.P.': [4091], 'Fischbarg': [4094], 'Vogelzang': [4098], 'S.A.': [4099], 'Ince': [4100], 'Ypey': [4102], 'Leijh': [4104], 'P.C.J.': [4105], '7988-7992Crossref': [4115], '(119)': [4118], '43Hickman': [4121], 'S.E.': [4122, 4196], 'El': [4123, 4197], 'Khoury': [4124, 4198], 'Greenberg': [4126, 4200], 'Schieren': [4128, 4202], '84:': [4134, 4208], '2452-2456Crossref': [4135, 4209], 'Yellow,': [4159], 'time-dependent': [4161, 4260], 'fluorescence': [4164, 4173, 4192, 4222, 4263, 4278], 'intensity': [4165, 4193, 4223, 4264], '3).': [4169, 4266, 4314], 'internalization': [4176], 'followed': [4181], 'binding': [4184], 'DNA;': [4186], 'bound': [4188], 'DNA,': [4190], '(43Hickman': [4195], 'significant': [4219], 'observed,': [4225], 'impermeable': [4231], 'plasma': [4234, 4297], 'nucleotide': [4241], 'triphosphate.': [4242], 'demonstrated': [4274], 'detergent': [4293, 4369], 'permeabilizes': [4295], 'membrane,': [4298], 'accumulates': [4301], 'extent': [4305], 'mediates': [4320], 'ATP-dependent': [4321], 'accumulation.': [4324], '[35S]methionine.': [4341], 'radiolabeled': [4343, 4465], 'separately,': [4364], 'extraction,': [4370], 'extracts': [4380, 4390], 'immunoprecipitation.': [4382], 'Radiolabeled': [4383], '35-kDa': [4384, 4408], '(Fig.4).': [4399], 'amount': [4401], 'cell-associated': [4407], '(assessed': [4410], 'phosphorimager': [4412], 'analysis)': [4413], '43,900': [4425], 'PSL/LDH': [4426, 4430], '44,100': [4429], 'equivalent,': [4431], 'respectively,': [4432], 'similarity': [4440], 'suggests': [4441], 'cell-types': [4445], 'amounts': [4448], 'activation.': [4455], 'Neither': [4456], 'nor': [4459], '4).': [4478, 4497], 'Treatment': [4479], '[35S]methionine-labeled': [4482], 'promoted': [4488], 'Cytokine': [4498], 'remained': [4500], 'cell-assoc': [4501]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2084383502', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 27}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 27}, {'year': 2020, 'cited_by_count': 29}, {'year': 2019, 'cited_by_count': 33}, {'year': 2018, 'cited_by_count': 34}, {'year': 2017, 'cited_by_count': 43}, {'year': 2016, 'cited_by_count': 46}, {'year': 2015, 'cited_by_count': 47}, {'year': 2014, 'cited_by_count': 38}, {'year': 2013, 'cited_by_count': 48}, {'year': 2012, 'cited_by_count': 60}], 'updated_date': '2025-01-09T15:07:19.875321', 'created_date': '2016-06-24'}