Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2084378161', 'doi': 'https://doi.org/10.1038/nature05938', 'title': 'Antitumour drugs impede DNA uncoiling by topoisomerase I', 'display_name': 'Antitumour drugs impede DNA uncoiling by topoisomerase I', 'publication_year': 2007, 'publication_date': '2007-06-24', 'ids': {'openalex': 'https://openalex.org/W2084378161', 'doi': 'https://doi.org/10.1038/nature05938', 'mag': '2084378161', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17589503'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature05938', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103140033', 'display_name': 'Daniel A. Koster', 'orcid': 'https://orcid.org/0000-0003-2129-1233'}, 'institutions': [{'id': 'https://openalex.org/I98358874', 'display_name': 'Delft University of Technology', 'ror': 'https://ror.org/02e2c7k09', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I98358874']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Daniel A. Koster', 'raw_affiliation_strings': ['Kavli Institute of NanoScience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands,'], 'affiliations': [{'raw_affiliation_string': 'Kavli Institute of NanoScience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands,', 'institution_ids': ['https://openalex.org/I98358874']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012316151', 'display_name': 'Komaraiah Palle', 'orcid': 'https://orcid.org/0000-0002-3182-0162'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Komaraiah Palle', 'raw_affiliation_strings': ["Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee 38105, USA."], 'affiliations': [{'raw_affiliation_string': "Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee 38105, USA.", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062526011', 'display_name': 'Elisa S. M. Bot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98358874', 'display_name': 'Delft University of Technology', 'ror': 'https://ror.org/02e2c7k09', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I98358874']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Elisa S. M. Bot', 'raw_affiliation_strings': ['Kavli Institute of NanoScience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands,'], 'affiliations': [{'raw_affiliation_string': 'Kavli Institute of NanoScience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands,', 'institution_ids': ['https://openalex.org/I98358874']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017941789', 'display_name': 'Mary‐Ann Bjornsti', 'orcid': 'https://orcid.org/0000-0002-6983-6282'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mary-Ann Bjornsti', 'raw_affiliation_strings': ["Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee 38105, USA."], 'affiliations': [{'raw_affiliation_string': "Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee 38105, USA.", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066937642', 'display_name': 'Nynke H. Dekker', 'orcid': 'https://orcid.org/0000-0003-4029-0973'}, 'institutions': [{'id': 'https://openalex.org/I98358874', 'display_name': 'Delft University of Technology', 'ror': 'https://ror.org/02e2c7k09', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I98358874']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Nynke H. Dekker', 'raw_affiliation_strings': ['Kavli Institute of NanoScience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands,'], 'affiliations': [{'raw_affiliation_string': 'Kavli Institute of NanoScience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands,', 'institution_ids': ['https://openalex.org/I98358874']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 9.515, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 281, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '448', 'issue': '7150', 'first_page': '213', 'last_page': '217'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12172', 'display_name': 'Neutropenia and Cancer Infections', 'score': 0.9822, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11827', 'display_name': 'Polyomavirus and related diseases', 'score': 0.9743, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.9123554}, {'id': 'https://openalex.org/keywords/topotecan', 'display_name': 'Topotecan', 'score': 0.76391697}], 'concepts': [{'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.9442625}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.9123554}, {'id': 'https://openalex.org/C158456008', 'wikidata': 'https://www.wikidata.org/wiki/Q412639', 'display_name': 'DNA supercoil', 'level': 4, 'score': 0.90134174}, {'id': 'https://openalex.org/C2781209748', 'wikidata': 'https://www.wikidata.org/wiki/Q419953', 'display_name': 'Topotecan', 'level': 3, 'score': 0.76391697}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.62226117}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.53839195}, {'id': 'https://openalex.org/C2780259306', 'wikidata': 'https://www.wikidata.org/wiki/Q412197', 'display_name': 'Irinotecan', 'level': 4, 'score': 0.49457428}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4533141}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4479239}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.4347657}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.4103081}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.40896583}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35060048}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33394283}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14406168}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.080950886}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004278', 'descriptor_name': 'DNA, Superhelical', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019772', 'descriptor_name': 'Topotecan', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004278', 'descriptor_name': 'DNA, Superhelical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008280', 'descriptor_name': 'Magnetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036103', 'descriptor_name': 'Nanotechnology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019772', 'descriptor_name': 'Topotecan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature05938', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17589503', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.52, 'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1536538430', 'https://openalex.org/W1549846058', 'https://openalex.org/W1571281254', 'https://openalex.org/W1581796882', 'https://openalex.org/W1871475547', 'https://openalex.org/W1968923197', 'https://openalex.org/W1985336260', 'https://openalex.org/W1999902563', 'https://openalex.org/W2001907809', 'https://openalex.org/W2022515199', 'https://openalex.org/W2028727595', 'https://openalex.org/W2031733136', 'https://openalex.org/W2032547020', 'https://openalex.org/W2034169319', 'https://openalex.org/W2056104020', 'https://openalex.org/W2057582459', 'https://openalex.org/W2057715047', 'https://openalex.org/W2058940094', 'https://openalex.org/W2082346169', 'https://openalex.org/W2083153561', 'https://openalex.org/W2087255750', 'https://openalex.org/W2099090001', 'https://openalex.org/W2118553080', 'https://openalex.org/W2120149213', 'https://openalex.org/W2124624490', 'https://openalex.org/W2132600317', 'https://openalex.org/W2137774806', 'https://openalex.org/W2146274229', 'https://openalex.org/W2160948762', 'https://openalex.org/W2401880799'], 'related_works': ['https://openalex.org/W4362068865', 'https://openalex.org/W2941541752', 'https://openalex.org/W261027724', 'https://openalex.org/W2322304890', 'https://openalex.org/W2128774674', 'https://openalex.org/W2104743561', 'https://openalex.org/W2098393177', 'https://openalex.org/W2028066947', 'https://openalex.org/W1988529521', 'https://openalex.org/W1985114772'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2084378161', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-08T22:40:25.014314', 'created_date': '2016-06-24'}