The Xenograft Antigen Bound to Griffonia simplicifolia Lectin 1-B4

Name: Work Video:
Duration: 3 min 30 s
W. Tempel; Sarah M. Tschampel; Robert J. Woods
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540, 593, 599, 683, 688, 723, 760, 767, 787, 792, 796, 862, 893, 905, 912, 1005, 1008, 1021, 1118, 1132, 1180, 1186, 1192, 1263, 1275, 1278, 1304, 1318, 1323, 1327, 1330, 1338, 1342, 1351, 1356, 1367, 1494, 1510, 1572, 1578, 1582, 1584, 1591, 1618, 1626, 1654, 1674, 1682, 1697, 1706, 1710, 1760, 1766, 1850, 1855, 1890, 1927, 1934, 1954, 1959, 1963, 2029, 2060, 2072, 2079, 2173, 2176, 2189, 2286, 2300, 2348, 2354, 2360, 2431, 2443, 2446, 2472, 2486, 2491, 2495, 2498, 2506, 2510, 2519, 2524, 2618, 2745, 2761, 2823, 2829, 2833, 2835, 2842, 2869, 2877, 2905, 2925, 2933, 2948, 2957, 2961, 2966, 2972, 2975, 2981, 3000], 'use': [19, 292], 'tissues': [21, 294, 597, 1764], 'from': [22, 101, 128, 295, 374, 401, 601, 1004, 1768, 2172], 'non-human': [23, 296], 'donors,': [24, 297], 'particularly': [25, 298], 'pig.': [26, 299], 'primary': [28, 301, 3001], 'barrier': [29, 302, 548, 1715], 'such': [31, 304], 'xenotransplantation': [32, 305, 550, 1717], 'is': [33, 243, 306, 516, 566, 680, 997, 1002, 1048, 1298, 1733, 1847, 2165, 2170, 2216, 2466], 'reaction': [35, 308], 'between': [36, 309, 1188, 2356], 'natural': [37, 96, 310, 369, 720, 1305, 1887, 2473], 'antibodies': [38, 97, 311, 370, 672, 721, 1190, 1839, 1888, 2358], 'present': [39, 312, 591, 790, 1585, 1758, 1957, 2836], 'in': [40, 195, 258, 266, 313, 468, 531, 539, 586, 673, 901, 950, 981, 1013, 1057, 1177, 1594, 1709, 1753, 1840, 2068, 2118, 2149, 2181, 2225, 2345, 2547, 2588, 2845, 2960], 'humans': [41, 314], 'and': [42, 46, 184, 228, 315, 319, 457, 501, 678, 731, 783, 940, 948, 959, 971, 979, 990, 1062, 1092, 1191, 1370, 1488, 1519, 1600, 1622, 1628, 1670, 1845, 1898, 1950, 2108, 2116, 2127, 2139, 2147, 2158, 2230, 2260, 2359, 2533, 2545, 2560, 2574, 2586, 2601, 2621, 2739, 2770, 2851, 2873, 2879, 2921, 2971], 'Old': [43, 316, 675, 1842], 'World': [44, 317, 676, 1843], 'monkeys': [45, 318, 677, 1844], 'Galα(1–3)Gal': [48, 321, 588, 686, 788, 1133, 1266, 1511, 1755, 1853, 1955, 2301, 2434, 2762], 'epitope': [49, 322, 789, 1956], '(xenograft': [50, 323, 589, 1756], 'antigen,': [51, 79, 324, 352], 'xenoantigen)': [52, 325], 'found': [53, 326, 1085, 1171, 2253, 2339], 'on': [54, 143, 156, 162, 327, 416, 429, 435, 592, 687, 791, 1020, 1625, 1659, 1759, 1854, 1958, 2188, 2876, 2910], 'cell': [56, 329, 689, 793, 1856, 1960], 'surfaces': [57, 330, 690, 794, 1857, 1961], 'donor': [60, 333, 797, 1964], 'organ.': [61, 334], 'This': [62, 335], 'hyperacute': [63, 270, 336, 543, 568, 1735], 'immune': [64, 337, 569, 864, 1736, 2031], 'response': [65, 338, 570, 865, 1737, 2032], 'leads': [66, 339], 'ultimately': [67, 340], 'graft': [69, 342], 'rejection.': [70, 272, 343, 545], 'Because': [71, 344], 'its': [73, 346, 1028, 2196], 'high': [74, 347, 1129, 2297], 'specificity': [75, 348], 'xenograft': [78, 116, 254, 271, 351, 389, 527, 544, 885, 1181, 1193, 1368, 2052, 2349, 2361, 2619], 'isolectin': [80, 353, 1120, 2288], '1-B4': [81, 354], 'fromGriffonia': [82, 355], 'simplicifolia': [83, 356, 932, 936, 967, 2100, 2104, 2135, 2528, 2569], '(GS-1-B4)': [84, 357, 1126, 2294], 'has': [85, 212, 358, 485, 866, 887, 1127, 1170, 2033, 2054, 2295, 2338], 'been': [86, 213, 359, 486, 740, 867, 1364, 1525, 1907, 2034, 2615, 2776], 'used': [87, 360, 1485, 2736], 'as': [88, 159, 161, 361, 432, 434, 1173, 1287, 1289, 1333, 1335, 1662, 1664, 2341, 2455, 2457, 2501, 2503, 2913, 2915], 'an': [89, 362, 1174, 1311, 2342, 2479], 'immunodiagnostic': [90, 363, 1175, 2343], 'reagent.': [91, 364], 'Furthermore,': [92, 365, 1183, 2351], 'haptens': [93, 366], 'that': [94, 215, 245, 367, 488, 518, 904, 1001, 1055, 1117, 2071, 2169, 2223, 2285], 'inhibit': [95, 99, 368, 372, 1196, 2364], 'also': [98, 148, 371, 421, 1195, 1686, 2363, 2937], 'GS-1-B4': [100, 240, 373, 513, 1169, 1200, 1268, 1297, 2337, 2368, 2436, 2465], 'binding': [102, 142, 375, 415, 1113, 1198, 1264, 1623, 1658, 2281, 2366, 2432, 2874, 2909], 'xenoantigen.': [105, 378, 1324, 2492], 'Here': [106, 379], 'we': [107, 146, 380, 419, 1348, 2516, 2990], 'report': [108, 147, 381, 420], 'first': [110, 383, 1339, 2507], 'x-ray': [111, 227, 384, 500, 1352, 1711, 2520, 2962], 'crystal': [112, 385, 1353, 2521], 'structure': [113, 125, 386, 398, 1340, 1354, 2508, 2522], 'antigen': [117, 255, 390, 528, 1194, 1369, 2362, 2620], 'bound': [118, 391, 1344, 1683, 1701, 2512, 2934, 2952], 'protein': [121, 394, 1657, 2908], '(GS-1-B4).': [122, 395], 'three-dimensional': [124, 397], 'was': [126, 399, 1084, 2252], 'determined': [127, 214, 400, 487, 1272, 1350, 2440, 2518], 'orthorhombic': [129, 402], 'crystals': [130, 403], 'at': [131, 404, 1597, 2848, 2980], 'resolution': [133, 406], '2.3': [135, 408], 'Å.': [136, 409], 'To': [137, 410, 856, 1325, 1570, 1652, 2023, 2493, 2821, 2903], 'probe': [138, 411], 'influence': [140, 413, 1619, 1655, 2870, 2906], 'ligand': [144, 417, 1529, 1593, 1660, 2780, 2844, 2911], 'properties,': [145, 418], 'results': [150, 423], 'molecular': [152, 425, 1520, 2549, 2590, 2771], 'dynamics': [153, 426, 1521, 2550, 2591, 2772], '(MD)': [154, 427, 1522, 2773], 'simulations': [155, 168, 187, 205, 428, 441, 460, 478, 1523, 1589, 1606, 1680, 1692, 2774, 2840, 2857, 2931, 2943], 'this': [157, 430, 737, 1904], 'complex': [158, 431], 'well': [160, 433, 1334, 1663, 2502, 2914], 'free': [164, 209, 437, 482, 1592, 2843], 'ligand.': [165, 438], 'MD': [167, 204, 440, 477, 1588, 1679, 2839, 2930], 'were': [169, 188, 442, 461, 1685, 2936], 'performed': [170, 189, 206, 443, 462, 479, 1687, 2938], 'with': [171, 178, 203, 444, 451, 476, 1616, 1688, 2867, 2939], 'AMBER': [173, 446, 2548, 2589], 'force-field': [174, 447], 'proteins': [176, 449], 'augmented': [177, 450], 'GLYCAM': [180, 453], 'parameters': [181, 454], 'glycosides': [183, 456, 2544, 2585], 'glycoproteins.': [185, 458], 'up': [191, 464], '10': [193, 466], 'ns': [194, 467], 'presence': [197, 470, 669, 1022, 1276, 1836, 2190, 2444], 'explicit': [199, 472, 1595, 1689, 2846, 2940], 'solvent.': [200, 473], 'Through': [201, 474], 'comparison': [202, 475], 'ligand,': [210, 483, 1583, 2834], 'it': [211, 484, 1308, 2476], 'GS-1-B4recognizes': [216, 489], 'lowest': [218, 491], 'energy': [219, 492, 941, 960, 972, 991, 1502, 1507, 2109, 2128, 2140, 2159, 2534, 2561, 2575, 2602, 2753, 2758], 'conformation': [220, 493], 'disaccharide.': [223, 496], 'In': [224, 497, 2988], 'addition,': [225, 498, 2989], 'modeling': [229, 502], 'data': [230, 503], 'provide': [231, 504, 1310, 1693, 2478, 2944], 'clear': [232, 505], 'explanations': [233, 506], 'reported': [236, 509, 1365, 2616], 'specificities': [237, 510], 'lectin.': [241, 514], 'It': [242, 515], 'anticipated': [244, 517], 'further': [247, 520], 'understanding': [248, 521], 'interactions': [251, 524, 1624, 2875], 'involving': [252, 525], 'will': [256, 529], 'help': [257, 530], 'development': [260, 533], 'therapeutic': [262, 535], 'agents': [263, 536], 'application': [265, 538, 1172, 2340], 'prevention': [268, 541], 'major': [547, 1714], '(1Auchincloss': [551, 742, 869, 917, 1718, 1909, 2036, 2084], 'H.': [552, 743, 870, 918, 1719, 1910, 2037, 2085], 'Sachs': [553, 744, 771, 871, 919, 1720, 1911, 1938, 2038, 2086], 'D.H.': [554, 745, 772, 872, 920, 1721, 1912, 1939, 2039, 2087], 'Annu.': [555, 746, 873, 921, 1722, 1913, 2040, 2088], 'Rev.': [556, 747, 874, 922, 1723, 1914, 2041, 2089], 'Immunol.': [557, 577, 632, 748, 875, 923, 1724, 1744, 1799, 1915, 2042, 2090], '1998;': [558, 749, 876, 924, 1725, 1916, 2043, 2091], '16:': [559, 750, 877, 925, 1726, 1917, 2044, 2092], '433-470Crossref': [560, 751, 878, 926, 1727, 1918, 2045, 2093], 'PubMed': [561, 581, 662, 714, 752, 778, 851, 879, 927, 1044, 1078, 1107, 1144, 1163, 1214, 1237, 1382, 1430, 1452, 1478, 1539, 1565, 1647, 1728, 1748, 1829, 1881, 1919, 1945, 2018, 2046, 2094, 2212, 2246, 2275, 2312, 2331, 2382, 2405, 2633, 2681, 2703, 2729, 2790, 2816, 2898], 'Scopus': [562, 582, 640, 663, 715, 753, 779, 852, 880, 928, 1108, 1145, 1164, 1215, 1238, 1258, 1383, 1418, 1431, 1453, 1479, 1540, 1566, 1648, 1729, 1749, 1807, 1830, 1882, 1920, 1946, 2019, 2047, 2095, 2276, 2313, 2332, 2383, 2406, 2426, 2634, 2669, 2682, 2704, 2730, 2791, 2817, 2899], '(377)': [563, 754, 881, 929, 1730, 1921, 2048, 2096], 'Google': [564, 584, 628, 642, 665, 717, 755, 781, 810, 854, 882, 930, 1045, 1079, 1110, 1147, 1166, 1217, 1240, 1260, 1385, 1403, 1420, 1433, 1455, 1481, 1542, 1568, 1650, 1731, 1751, 1795, 1809, 1832, 1884, 1922, 1948, 1977, 2021, 2049, 2097, 2213, 2247, 2278, 2315, 2334, 2385, 2408, 2428, 2636, 2654, 2671, 2684, 2706, 2732, 2793, 2819, 2901], 'Scholar)': [565, 1732], '(2Platt': [571, 1738], 'J.L.': [572, 770, 1230, 1739, 1937, 2398], 'Bach': [573, 1740], 'F.H.': [574, 1741], 'Curr.': [575, 1742], 'Opin.': [576, 1743], '1991;': [578, 1745], '3:': [579, 1256, 1746, 2424], '735-739Crossref': [580, 1747], '(43)': [583, 1750], 'Scholar),': [585, 756, 782, 1752, 1923, 1949], 'which': [587, 1575, 1754, 2826], 'antigen)': [590, 1757], 'surface': [594, 724, 1761, 1891], 'non-primate': [596, 1763], 'triggers': [598, 1765], 'rejection': [600, 886, 1767, 2053], 'transplant': [603, 1770], 'recipients': [604, 1771], '(3Good': [605, 1772], 'A.H.': [606, 1773], 'Cooper': [607, 1774], 'D.K.C.': [608, 1775], 'Malcolm': [609, 1776], 'A.J.': [610, 826, 842, 1777, 1993, 2009], 'Ippolito': [611, 1778], 'R.M.': [612, 1779], 'Koren': [613, 1780], 'E.': [614, 1438, 1781, 2689], 'Neethling': [615, 1782], 'F.A.,': [616, 1783], 'Ye,': [617, 1784], 'Y.': [618, 1785], 'Zuhdi': [619, 1786], 'N.': [620, 1787], 'Lamontagne': [621, 1788], 'L.R.': [622, 1789], 'Transplant.': [623, 805, 1790, 1972], 'Proc.': [624, 652, 704, 806, 1637, 1791, 1819, 1871, 1973, 2888], '1992;': [625, 1792], '24:': [626, 1793], '559-562PubMed': [627, 1794], 'Scholar,': [629, 643, 811, 1148, 1218, 1241, 1386, 1404, 1421, 1434, 1456, 1543, 1796, 1810, 1978, 2316, 2386, 2409, 2637, 2655, 2672, 2685, 2707, 2794], '4Galili': [630, 1797], 'U.': [631, 656, 695, 708, 1641, 1798, 1823, 1862, 1875, 2892], 'Today.': [633, 1800], '1993;': [634, 659, 1801, 1826], '14:': [635, 1212, 1802, 2380], '280-482Abstract': [636, 1803], 'Full': [637, 1041, 1075, 1804, 2209, 2243], 'Text': [638, 1042, 1076, 1805, 2210, 2244], 'PDF': [639, 1043, 1077, 1806, 2211, 2245], '(573)': [641, 1808], '5Sandrin': [644, 1811], 'M.S.': [645, 1202, 1812, 2370], 'Vaughan': [646, 1203, 1813, 2371], 'H.A.': [647, 1204, 1243, 1814, 2372, 2411], 'Dabkowski': [648, 1815], 'P.L.': [649, 838, 1226, 1816, 2005, 2394], 'McKenzie': [650, 1207, 1250, 1817, 2375, 2418], 'I.F.C.': [651, 1208, 1251, 1818, 2376, 2419], 'Natl.': [653, 705, 1638, 1820, 1872, 2889], 'Acad.': [654, 706, 1639, 1821, 1873, 2890], 'Sci.': [655, 707, 1640, 1822, 1874, 2891], 'S.': [657, 709, 1394, 1446, 1642, 1824, 1876, 2645, 2697, 2893], 'A.': [658, 710, 1436, 1643, 1825, 1877, 2687, 2894], '90:': [660, 1827], '11391-11395Crossref': [661, 1828], '(551)': [664, 1831], 'Scholar).': [666, 718, 855, 883, 1046, 1080, 1111, 1167, 1261, 1482, 1569, 1651, 1833, 1885, 2022, 2050, 2098, 2214, 2248, 2279, 2335, 2429, 2733, 2820, 2902], 'ubiquitous': [668, 1835], 'anti-Galα(1–3)Gal': [671, 761, 863, 1189, 1838, 1928, 2030, 2357], 'humans,': [674, 1841], 'apes': [679, 1846], 'paralleled': [681, 1848], 'by': [682, 909, 1274, 1849, 2076, 2442], 'absence': [684, 1851], 'those': [692, 1859], 'species': [693, 798, 1860, 1965], '(6Galili': [694, 1861], 'Clark': [696, 1863], 'M.R.': [697, 1864], 'Shohet': [698, 1865], 'S.B.': [699, 1222, 1866, 2390], 'Buehler': [700, 1867], 'J.': [701, 1035, 1069, 1210, 1398, 1411, 1440, 1448, 1458, 1470, 1545, 1557, 1868, 2203, 2237, 2378, 2649, 2662, 2691, 2699, 2709, 2721, 2796, 2808], 'Macher': [702, 1869], 'B.A.': [703, 1870], '1987;': [711, 1878], '84:': [712, 1879], '1369-1373Crossref': [713, 1880], '(508)': [716, 1883], 'attack': [722, 1889], 'endothelial': [725, 1892], 'cells': [726, 1893], 'leading': [727, 1894], 'complement': [729, 1896], 'activation': [730, 1897], 'organ': [732, 897, 1899, 2064], 'death.': [733, 1900], 'Several': [734, 1901], 'approaches': [735, 1902], 'problem': [738, 1905], 'have': [739, 1115, 1349, 1363, 1524, 1906, 2283, 2517, 2614, 2775], 'considered': [741, 1908], 'including': [757, 1924], 'inhibition': [758, 1925], 'antibodies,': [762, 1929], 'induction': [763, 1930], 'tolerance': [765, 1932], 'xenoantigen': [768, 1343, 1935, 2511], '(7Greenstein': [769, 1936], 'Nat.': [773, 1940], 'Biotech.': [774, 1941], '1997;': [775, 1211, 1942, 2379], '15:': [776, 1943], '235-237Crossref': [777, 1944], '(25)': [780, 1947], 'transgenic': [784, 1951], 'alteration': [785, 1952], '(8Thall': [799, 1966], 'A.D.': [800, 1967], 'Murphy': [801, 1153, 1968, 2321], 'H.S.': [802, 1969], 'Lowe': [803, 1970], 'J.B.': [804, 1971], '1996;': [807, 848, 1234, 1255, 1974, 2015, 2402, 2423], '28:': [808, 1975], '556-557PubMed': [809, 1976], '9Tearle': [812, 1979], 'R.G.': [813, 1980], 'Tange': [814, 1981], 'M.J.': [815, 844, 1982, 2011], 'Zannettino': [816, 1983], 'Z.L.': [817, 1984], 'Katerelos': [818, 1985], 'M.': [819, 1253, 1986, 2421], 'Shinkel': [820, 1987], 'T.A.': [821, 1988], 'Van': [822, 1989], 'Denderen': [823, 1990], 'B.J.W.': [824, 1991], 'Lonie': [825, 1992], 'Lyons': [827, 1994], 'I.': [828, 1995], 'Nottle': [829, 1996], 'M.B.': [830, 1460, 1547, 1997, 2711, 2798], 'Cox': [831, 1998], 'T.': [832, 1999], 'Becker': [833, 2000], 'C.': [834, 1150, 2001, 2318], 'Peura': [835, 2002], 'A.M.': [836, 2003], 'Wigley': [837, 2004], 'Crawford': [839, 2006], 'R.J.': [840, 1636, 2007, 2887], 'Robins': [841, 2008], 'Pearse': [843, 2010], "D'Apice": [845, 2012], 'A.J.F.': [846, 2013], 'Transplantation.': [847, 1233, 2014, 2401], '61:': [849, 1235, 2016, 2403], '13-19Crossref': [850, 2017], '(264)': [853, 2020], 'date,': [857, 2024], 'only': [858, 2025], 'transient': [859, 2026], 'suppression': [860, 2027], 'achieved': [868, 2035], 'Overcoming': [884, 2051], 'become': [888, 2055], 'increasingly': [889, 2056], 'important': [890, 2057], 'due': [891, 2058], 'huge': [894, 2061], 'demand': [895, 906, 2062, 2073], 'transplants;': [898, 2065], 'study': [900, 1586, 2067, 2837], '1998': [902, 916, 2069, 2083], 'estimated': [903, 2070], 'had': [907, 2074], 'increased': [908, 2075], '100%': [910, 2077], 'over': [911, 2078], 'period': [913, 2080], '1990': [914, 2081], 'through': [915, 2082], 'Scholar).Griffonia': [931], 'lectin-1': [933, 2101, 2529, 2570], '(GS-1)': [934, 2102], '1GS-1G.': [935, 966, 2103, 2134], 'lectin-1AMBERassisted': [937, 968, 2105, 2136], 'model': [938, 969, 1302, 2106, 2137, 2470, 2531, 2572], 'building': [939, 970, 2107, 2138, 2532, 2573], 'refinementCNScrystallography': [942, 973, 2110, 2141], '&': [943, 974, 2111, 2142, 2537, 2578], 'NMR': [944, 975, 1489, 2112, 2143, 2538, 2579, 2740], 'systemCRDcarbohydrate': [945, 976, 2113, 2144], 'recognition': [946, 977, 1321, 2114, 2145, 2489, 2541, 2582], 'domainGald-galactopyranosylGLYCAMglycosides': [947, 978, 2115, 2146], 'glycoproteins': [949, 980, 2117, 2148, 2546, 2587], 'AMBERMDmolecular': [951, 982, 2119, 2150], 'dynamicsNCSnoncrystallographic': [952, 983, 2120, 2151], 'symmetryRCSBResearch': [953, 984, 2121, 2152], 'Collaboratory': [954, 985, 2122, 2153, 2554, 2595], 'Structural': [956, 987, 2124, 2155, 2556, 2597], 'BioinformaticsSANDERsimulated': [957, 988, 2125, 2156], 'annealing': [958, 989, 2126, 2157, 2559, 2600], 'refinementTIP3Ptransferable': [961, 992, 2129, 2160], 'intermolecular': [962, 993, 2130, 2161, 2564, 2605], 'potential': [963, 994, 2131, 2162, 2565, 2606], '−3': [964, 995, 2132, 2163, 2566, 2607], 'point': [965, 996, 2133, 2164, 2567, 2608], 'carbohydrate-binding': [999, 1029, 2167, 2197], 'glycoprotein': [1000, 2168], 'isolated': [1003, 2171], 'seeds': [1006, 2174], 'African': [1009, 2177], 'leguminous': [1010, 2178], 'shrub.': [1011, 2179], 'As': [1012, 2180], 'many': [1014, 2182], 'other': [1015, 1282, 2183, 2450], 'legume': [1016, 2184], 'lectins,': [1017, 2185], 'GS-1': [1018, 1047, 1119, 2186, 2215, 2287], 'relies': [1019, 2187], 'divalent': [1024, 2192], 'metal': [1025, 2193], 'cations': [1026, 2194], 'activity': [1030, 2198], '(10Hayes': [1031, 2199], 'C.E.': [1032, 2200], 'Goldstein': [1033, 1067, 1155, 2201, 2235, 2323], 'I.J.': [1034, 1068, 1099, 1136, 1156, 1374, 2202, 2236, 2267, 2304, 2324, 2625], 'Biol.': [1036, 1070, 2204, 2238], 'Chem.': [1037, 1071, 1399, 1413, 2205, 2239, 2650, 2664], '1974;': [1038, 2206], '249:': [1039, 2207], '1904-1914Abstract': [1040, 2208], 'mixture': [1050, 2218], 'five': [1052, 2220], 'tetrameric': [1053, 2221], 'isolectins': [1054, 2222], 'vary': [1056, 2224], 'their': [1058, 2226], 'content': [1059, 2227], 'A': [1061, 1082, 2229, 2250, 2609], 'B': [1063, 1124, 2231, 2292], 'subunits': [1064, 1125, 2232, 2293], '(11Murphy': [1065, 2233], 'L.A.': [1066, 1154, 2234, 2322], '1977;': [1072, 2240], '252:': [1073, 2241], '4739-4742Abstract': [1074, 2242], 'subunit': [1083, 2251], 'bind': [1087, 2255], 'strongly': [1088, 2256], 'both': [1090, 1486, 1515, 2258, 2737, 2766], 'GalNAcα': [1091, 1097, 2259, 2265], 'Galα': [1093, 1294, 2261, 2462], 'residues,': [1094, 2262], 'while': [1095, 2263], 'favoring': [1096, 2264], '(12Goldstein': [1098, 1135, 1373, 2266, 2303, 2624], 'Winter': [1100, 1137, 1375, 2268, 2305, 2626], 'H.G.': [1101, 1138, 1376, 2269, 2306, 2627], 'Subcell.': [1102, 1139, 1377, 2270, 2307, 2628], 'Biochem.': [1103, 1140, 1158, 1378, 2271, 2308, 2326, 2629], '1999;': [1104, 1141, 1379, 1475, 1562, 2272, 2309, 2630, 2726, 2813], '32:': [1105, 1142, 1380, 2273, 2310, 2631], '127-140Crossref': [1106, 1143, 1381, 2274, 2311, 2632], '(32)': [1109, 1146, 1384, 2277, 2314, 2635], 'Competitive': [1112, 2280], 'studies': [1114, 1178, 1362, 1484, 1499, 2282, 2346, 2613, 2735, 2750], 'shown': [1116, 2284], 'composed': [1121, 2289], 'four': [1123, 2291], 'affinity': [1130, 2298], 'sequence': [1134, 2302, 3002], '13Wood': [1149, 2317], 'Kabat': [1151, 2319], 'E.A.': [1152, 2320], 'Arch.': [1157, 2325], 'Biophys.': [1159, 2327], '1979;': [1160, 2328], '198:': [1161, 2329], '1-11Crossref': [1162, 2330], '(143)': [1165, 2333], 'Therefore,': [1168, 2336], 'reagent': [1176, 2344], 'antigen.': [1182, 2350], 'inhibitors': [1184, 2352], 'interaction': [1187, 1708, 2355, 2959], 'carbohydrate': [1197, 2365, 2540, 2581], '(14Sandrin': [1201, 2369], 'Xing': [1205, 2373], 'P.-X.': [1206, 2374], 'Glycoconj.': [1209, 1447, 2377, 2698], '97-105Crossref': [1213, 2381], '(53)': [1216, 2384], '15Kooyman': [1219, 2387], 'D.L.': [1220, 2388], 'McCClellan': [1221, 2389], 'Parker': [1223, 2391], 'W.': [1224, 1462, 1549, 2392, 2713, 2800], 'Avissar': [1225, 2393], 'Velardo': [1227, 2395], 'M.A.': [1228, 1247, 2396, 2415], 'Platt': [1229, 2397], 'Logan': [1231, 2399], 'J.S.': [1232, 2400], '851-855Crossref': [1236, 2404], '(37)': [1239, 2407], '16Vaughan': [1242, 2410], 'Oldenburg': [1244, 2412], 'K.R.': [1245, 2413], 'Gallop': [1246, 2414], 'Atkin': [1248, 2416], 'J.D.': [1249, 2417], 'Sandrin': [1252, 2420], 'Xenotransplantation.': [1254, 2422], '18-23Crossref': [1257, 2425], '(34)': [1259, 2427], 'Notably,': [1262, 2430], 'appears': [1269, 2437], 'primarily': [1273, 2441], 'terminal': [1279, 1293, 2447, 2461], 'α-galactosyl': [1280, 2448], 'residue;': [1281, 2449], 'linkages': [1283, 2451], 'may': [1284, 2452], 'tolerated,': [1286, 2454], 'long': [1288, 1604, 2456, 2855], 'they': [1290, 1611, 2458, 2862], 'contain': [1291, 2459], 'residue.': [1295, 2463], 'Thus,': [1296, 2464], 'not': [1299, 2467], 'perfect': [1301, 2469], 'antibodies;': [1306, 2474], 'however,': [1307, 1610, 2475, 2861], 'does': [1309, 2477], 'opportunity': [1312, 2480], 'gain': [1314, 2482], 'detailed': [1315, 2483], 'insight': [1316, 1695, 2484, 2946], 'mechanism': [1319, 1328, 2487, 2496], 'determine': [1326, 1493, 1571, 2494, 2744, 2822], 'observed': [1331, 2499], 'specificities,': [1332, 2500], 'obtain': [1337, 1666, 2505, 2917], 'protein,': [1347, 2515], 'GS-1-B4·Galα(1–3)Gal': [1357, 2525], 'complex.A': [1358], 'number': [1359, 2610], 'structural': [1361, 1698, 2612, 2949], 'related': [1371, 2622], 'oligosaccharides': [1372, 2623], '17Lemieux': [1387, 2638], 'R.U.': [1388, 2639], 'Bock': [1389, 2640], 'K.': [1390, 2641], 'Delbaere': [1391, 2642], 'L.T.J.': [1392, 2643], 'Koto': [1393, 2644], 'Rao': [1395, 1409, 2646, 2660], 'V.S.': [1396, 2647], 'Can.': [1397, 2648], '1980;': [1400, 2651], '58:': [1401, 2652], '631-653Crossref': [1402, 2653], '18Bush': [1405, 2656], 'C.A.': [1406, 2657], 'Yan': [1407, 2658], 'Z.-Y.': [1408, 2659], 'B.N.N.': [1410, 2661], 'Am.': [1412, 2663], 'Soc.': [1414, 2665], '1986;': [1415, 2666], '108:': [1416, 2667], '6168-6173Crossref': [1417, 2668], '(76)': [1419, 2670], '19Yan': [1422, 2673], 'Z.-y.': [1423, 1532, 2674, 2783], 'Bush': [1424, 1533, 2675, 2784], 'A.C.': [1425, 1534, 2676, 2785], 'Biopolymers.': [1426, 1535, 2677, 2786], '1990;': [1427, 1536, 2678, 2787], '29:': [1428, 1537, 2679, 2788], '799-811Crossref': [1429, 1538, 2680, 2789], '(74)': [1432, 1541, 2683, 2792], '20Imberty': [1435, 2686], 'Mikros': [1437, 2688], 'Koca': [1439, 2690], 'Mollicone': [1441, 2692], 'R.': [1442, 1444, 2693, 2695], 'Oriol': [1443, 2694], 'Pérez': [1445, 2696], '1995;': [1449, 2700], '12:': [1450, 2701], '331-349Crossref': [1451, 2702], '(123)': [1454, 2705], '21Li': [1457, 1544, 2708, 2795], 'Ksebati': [1459, 1546, 2710, 2797], 'Zhang': [1461, 1548, 2712, 2799], 'Guo': [1463, 1550, 2714, 2801], 'Z.': [1464, 1551, 2715, 2802], 'Wang': [1465, 1552, 2716, 2803], 'J.,': [1466, 1553, 2717, 2804], 'Yu,': [1467, 1554, 2718, 2805], 'L.': [1468, 1555, 2719, 2806], 'Fang': [1469, 1556, 2720, 2807], 'George': [1471, 1558, 2722, 2809], 'W.P.': [1472, 1559, 2723, 2810], 'Carbohydr.': [1473, 1560, 2724, 2811], 'Res.': [1474, 1561, 2725, 2812], '315:': [1476, 1563, 2727, 2814], '76-88Crossref': [1477, 1564, 2728, 2815], '(10)': [1480, 1567, 2731, 2818], 'These': [1483, 1603, 1691, 2734, 2854, 2942], 'computational': [1487, 1498, 2738, 2749], 'spectroscopic': [1490, 2741], 'methods': [1491, 2742], 'solution': [1495, 2746], 'conformation.': [1496, 2747], 'Earlier': [1497, 2748], 'employed': [1500, 1526, 1587, 2751, 2777, 2838], 'adiabatic': [1501, 2752], 'mapping': [1503, 2754], 'predict': [1505, 1615, 2756, 2866], 'low': [1506, 2757], 'conformations': [1508, 2759], 'linkage.': [1512, 2763], 'More': [1513, 2764], 'recently,': [1514, 2765], 'gas-phase': [1516, 2767], 'Monte': [1517, 2768], 'Carlo': [1518, 2769], 'examine': [1528, 1653, 2779, 2904], 'flexibility': [1530, 2781], '(19Yan': [1531, 2782], 'extent': [1573, 2824], 'water': [1576, 1596, 2827, 2847], 'mediates': [1577, 2828], 'conformational': [1579, 1627, 2830, 2878], 'properties': [1580, 1630, 2831, 2881], 'atmospheric': [1598, 2849], 'pressure': [1599, 2850], 'room': [1601, 2852], 'temperature.': [1602, 2853], '10-ns': [1605, 2856], 'are': [1607, 1612, 2858, 2863, 2991], 'extremely': [1608, 2859], 'computer-intensive,': [1609, 2860], 'able': [1613, 2864], 'accuracy': [1617, 2868], 'solvation': [1621, 2872], 'dynamic': [1629, 2880], 'carbohydrates': [1632, 2883], '(22Kirschner': [1633, 2884], 'K.N.': [1634, 2885], 'Woods': [1635, 2886], '2001;': [1644, 2895], '98:': [1645, 2896], '10541-10545Crossref': [1646, 2897], '(437)': [1649, 2900], 'dynamics,': [1661, 2912], 'complete': [1668, 2919], 'spatial': [1669, 2920], 'temporal': [1671, 2922], 'picture': [1672, 2923], 'interaction,': [1675, 2926], '2-': [1676, 2927], '5-ns': [1678, 2929], 'complex,': [1684, 2935], 'water.': [1690, 2941], 'additional': [1694, 2945], 'significance': [1699, 2950], 'waters,': [1702, 2953], 'seen': [1703, 2954], 'mediate': [1705, 2956], 'carbohydrate-protein': [1707, 2958], 'structure.': [1712, 2963], 'Griffonia': [2099], 'complex.': [2526], 'G.': [2527, 2568], 'assisted': [2530, 2571], 'refinement': [2535, 2562, 2576, 2603], 'crystallography': [2536, 2577], 'system': [2539, 2580], 'domain': [2542, 2583], 'd-galactopyranosyl': [2543, 2584], 'noncrystallographic': [2551, 2592], 'symmetry': [2552, 2593], 'Research': [2553, 2594, 2979], 'Bioinformatics': [2557, 2598], 'simulated': [2558, 2599], 'transferable': [2563, 2604], 'We': [2964], 'thank': [2965], 'National': [2967], 'Institutes': [2968], 'Health': [2970], 'Office': [2973], 'Vice': [2976], 'President': [2977], 'University': [2982], 'Georgia': [2984], 'financial': [2986], 'support.': [2987], 'indebted': [2992], 'Dr.': [2994], 'Anne': [2995], 'Imberty': [2996], 'generously': [2998], 'providing': [2999], 'GS-1-B4.': [3004]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2084369885', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}], 'updated_date': '2024-12-17T13:43:08.778705', 'created_date': '2016-06-24'}
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