Publication Information

{'id': 'https://openalex.org/W2084361108', 'doi': 'https://doi.org/10.1074/jbc.m107169200', 'title': 'Topology of a Human Equilibrative, Nitrobenzylthioinosine (NBMPR)-sensitive Nucleoside Transporter (hENT1) Implicated in the Cellular Uptake of Adenosine and Anti-cancer Drugs', 'display_name': 'Topology of a Human Equilibrative, Nitrobenzylthioinosine (NBMPR)-sensitive Nucleoside Transporter (hENT1) Implicated in the Cellular Uptake of Adenosine and Anti-cancer Drugs', 'publication_year': 2001, 'publication_date': '2001-11-01', 'ids': {'openalex': 'https://openalex.org/W2084361108', 'doi': 'https://doi.org/10.1074/jbc.m107169200', 'mag': '2084361108', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11584005'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m107169200', 'pdf_url': 'http://www.jbc.org/article/S0021925819827382/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819827382/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081834383', 'display_name': 'Manickavasagam Sundaram', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Manickavasagam Sundaram', 'raw_affiliation_strings': ['Membrane Transport Research Group, Edmonton, Alberta T6G 2H7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Membrane Transport Research Group, Edmonton, Alberta T6G 2H7, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111969636', 'display_name': 'Sylvia Y.M. Yao', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sylvia Y.M. Yao', 'raw_affiliation_strings': ['Membrane Transport Research Group, Edmonton, Alberta T6G 2H7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Membrane Transport Research Group, Edmonton, Alberta T6G 2H7, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109197156', 'display_name': 'Jean C. Ingram', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jean C. Ingram', 'raw_affiliation_strings': ['Membrane Transport Research Group, Edmonton, Alberta T6G 2H7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Membrane Transport Research Group, Edmonton, Alberta T6G 2H7, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084390763', 'display_name': 'Zoe Berry', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Zoe A. 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'physiologic': [27, 176], 'nucleosides,': [28, 177, 351, 831], 'including': [29, 178, 832, 1112], 'adenosine,': [30, 179, 833], 'and': [31, 43, 46, 85, 111, 113, 123, 141, 180, 192, 195, 234, 260, 262, 272, 290, 324, 368, 371, 434, 491, 497, 574, 582, 605, 701, 816, 820, 829, 834, 848, 858, 867, 876, 1009, 1015, 1117, 1119, 1200, 1340, 1390, 1427, 1452, 1577, 1596, 1599, 1613, 1737, 1754, 1819], 'many': [32, 181, 438], 'anti-cancer': [33, 182], 'drugs.': [35, 184], 'We': [36, 185], 'have': [37, 186, 696, 859, 877, 1415, 1589], 'produced': [38, 187, 1590], 'recombinant': [39, 188, 1591], 'hENT1': [40, 65, 189, 214, 847, 1592, 1654], 'inXenopus': [41, 190], 'oocytes': [42, 191, 1595], 'used': [44, 193, 442, 568, 1597], 'native': [45, 194, 1598, 1609], 'engineeredN-glycosylation': [47, 196], 'sites': [48, 197, 1473, 1602], 'in': [49, 198, 322, 362, 399, 443, 464, 483, 538, 650, 680, 687, 699, 841, 995, 1109, 1126, 1284, 1327, 1336, 1386, 1418, 1490, 1593, 1603, 1611, 1653, 1713, 1792, 1825, 1830], 'combination': [50, 199, 1604], 'with': [51, 78, 200, 227, 1205, 1605, 1629], 'immunological': [52, 201, 1606], 'approaches': [53, 202], 'to': [54, 72, 134, 203, 221, 283, 570, 843, 997, 1017, 1123, 1343, 1378, 1444, 1461, 1471, 1483, 1541, 1563, 1574, 1616], 'experimentally': [55, 204, 1434, 1617], 'define': [56, 205, 1618], 'architecture': [59, 208, 1641], 'this': [61, 129, 210, 278, 1622], 'prototypic': [62, 211], 'transporter.': [64, 213], '(456': [66, 215], 'amino': [67, 80, 216, 229, 823, 1383, 1499, 1661], 'acid': [68, 217, 824, 1223, 1384, 1500, 1662], 'residues)': [69, 218, 825], 'shown': [71, 220], 'contain': [73, 222], '11': [74, 223, 1160], 'transmembrane': [75, 108, 120, 224, 257, 269, 1162, 1228, 1328, 1388, 1424, 1651, 1729], 'helical': [76, 225], 'segments': [77, 226, 1579], 'an': [79, 228], 'terminus': [81, 88, 230, 237], 'that': [82, 89, 128, 231, 238, 277, 375, 1375], 'intracellular': [84, 233], 'a': [86, 102, 114, 235, 251, 263, 355, 681, 839, 1216, 1446, 1636], 'carboxyl': [87, 236], 'extracellular.': [91, 240], 'Transmembrane': [92, 241], 'helices': [93, 109, 121, 242, 258, 270, 1163, 1229, 1389, 1425, 1652, 1730], 'are': [94, 243, 678, 685, 835, 850, 869, 1106], 'linked': [95, 244], 'by': [96, 245, 598, 838, 845, 853, 871, 999, 1010, 1300, 1657, 1895], 'short': [97, 246], 'hydrophilic': [98, 247], 'regions,': [99, 248, 1429], 'except': [100, 249, 1501], 'large': [103, 115, 252, 264], 'glycosylated': [104, 253], 'extracellular': [105, 254, 479, 1213, 1565], 'loop': [106, 118, 255, 267], 'between': [107, 119, 256, 268], '1': [110, 259], '2': [112, 261], 'central': [116, 265], 'cytoplasmic': [117, 266], '6': [122, 271], '7.': [124, 273], 'Sequence': [125, 274], 'analyses': [126, 275], 'suggest': [127, 276], 'topology': [131, 280, 1148, 1620], 'common': [133, 282], 'all': [135, 284, 1643], 'mammalian,': [136, 285], 'insect,': [137, 286], 'nematode,': [138, 287], 'protozoan,': [139, 288], 'yeast,': [140, 289, 1116], 'plant': [142, 291], 'members': [143, 292, 599, 1785], 'protein': [147, 296, 1221, 1477, 1582, 1789], 'family.': [148, 297], 'concentrative': [298], 'nitrobenzylthioinosine': [304], 'p-chloromercuriphenylsulfonate': [305], 'polymerase': [306], 'chain': [307], 'reaction': [308], 'enzyme-linked': [309], 'immunosorbent': [310], 'assay': [311], 'bovine': [312], 'serum': [313], 'albumin': [314], 'phosphate-buffered': [315], 'saline': [316], 'Nucleoside': [317, 474], 'transporters': [318, 433, 475], 'play': [319], 'key': [320], 'roles': [321, 1422], 'physiology': [323], 'pharmacology': [325], '(1Baldwin': [326, 500, 612, 1024], 'S.A.': [327, 392, 416, 457, 501, 531, 555, 613, 643, 667, 725, 747, 779, 903, 925, 957, 1025, 1053, 1135, 1185, 1242, 1270, 1311, 1804, 1854, 1876], 'Mackey': [328, 387, 452, 502, 526, 614, 638, 1026], 'J.R.': [329, 388, 453, 503, 527, 615, 639, 1027], 'Cass': [330, 389, 411, 454, 504, 528, 550, 616, 640, 662, 720, 744, 774, 898, 922, 952, 1028, 1048, 1130, 1180, 1239, 1267, 1308, 1799, 1849, 1873], 'C.E.': [331, 390, 412, 455, 505, 529, 551, 617, 641, 663, 713, 721, 745, 775, 891, 899, 923, 953, 1029, 1049, 1131, 1173, 1181, 1240, 1268, 1309, 1800, 1842, 1850, 1874], 'Young': [332, 413, 506, 552, 618, 664, 722, 748, 776, 900, 926, 954, 1030, 1050, 1132, 1182, 1243, 1271, 1312, 1801, 1851, 1877], 'J.D.': [333, 384, 414, 449, 507, 523, 553, 619, 635, 665, 723, 749, 777, 901, 927, 955, 1031, 1051, 1090, 1133, 1183, 1244, 1272, 1313, 1802, 1852, 1878], 'Mol.': [334, 417, 508, 556, 620, 668, 1032, 1054, 1136, 1744, 1805], 'Med.': [335, 509, 621, 727, 905, 1033, 1187, 1856], 'Today.': [336, 510, 622, 1034], '1999;': [337, 511, 623, 1035, 1404], '5:': [338, 512, 624, 1036, 1772], '216-224Abstract': [339, 513, 625, 1037], 'Full': [340, 514, 626, 756, 758, 804, 806, 934, 936, 982, 984, 1038, 1077, 1079, 1251, 1253, 1530, 1532, 1885, 1887], 'Text': [341, 515, 627, 757, 759, 805, 807, 935, 937, 983, 985, 1039, 1078, 1080, 1252, 1254, 1531, 1533, 1886, 1888], 'PDF': [342, 516, 628, 760, 808, 938, 986, 1040, 1081, 1255, 1534, 1889], 'PubMed': [343, 423, 517, 562, 629, 674, 731, 761, 785, 809, 909, 939, 963, 987, 1041, 1060, 1082, 1100, 1142, 1191, 1256, 1277, 1319, 1361, 1407, 1513, 1535, 1749, 1774, 1811, 1860, 1890, 1909], 'Scopus': [344, 518, 630, 732, 762, 786, 810, 910, 940, 964, 988, 1042, 1083, 1101, 1192, 1257, 1278, 1362, 1408, 1514, 1536, 1750, 1775, 1861, 1891, 1910], '(302)': [345, 519, 631, 1043], 'Google': [346, 424, 520, 563, 632, 675, 734, 764, 788, 812, 912, 942, 966, 990, 1044, 1061, 1085, 1103, 1143, 1194, 1259, 1280, 1320, 1364, 1410, 1516, 1538, 1752, 1777, 1812, 1863, 1893, 1912], 'Scholar).': [347, 425, 473, 564, 676, 813, 991, 1104, 1144, 1195, 1281, 1321, 1365, 1411, 1539, 1778], 'Uptake': [348], 'exogenous': [350], 'example,': [353], 'critical': [356], 'step': [358], 'nucleotide': [360], 'synthesis': [361], 'tissues': [363, 703], 'such': [364, 494, 578], 'as': [365, 431, 495, 579, 585, 1020, 1022, 1711], 'bone': [366], 'marrow': [367], 'intestinal': [369], 'epithelium': [370], 'certain': [372], 'parasitic': [373], 'organisms': [374], 'lack': [376], 'de': [377], 'novo': [378], 'pathways': [379], 'purine': [381, 828], 'biosynthesis': [382], '(2Young': [383, 448], 'Cheeseman': [385, 450, 524, 636], 'C.I.': [386, 451, 525, 637], 'Baldwin': [391, 415, 456, 530, 554, 642, 666, 724, 746, 778, 902, 924, 956, 1052, 1134, 1184, 1241, 1269, 1310, 1803, 1853, 1875], 'Barrett': [393, 458, 532, 644], 'K.E.': [394, 459, 533, 645], 'Donowitz': [395, 460, 534, 646], 'M.': [396, 461, 535, 647, 705, 711, 743, 767, 883, 889, 921, 945, 1165, 1171, 1232, 1238, 1262, 1305, 1834, 1840, 1866, 1872], 'Current': [397, 462, 536, 648], 'Topics': [398, 463, 537, 649], 'Membranes.': [400, 465, 539, 651], '50.': [401, 466, 540, 652], 'Academic': [402, 467, 541, 653], 'Press,': [403, 468, 542, 654, 1705], 'San': [404, 469, 543, 655], 'Diego,': [405, 470, 544, 656], 'CA2000:': [406, 471, 545, 657], '329-378Google': [407, 472, 546, 658], 'Scholar,': [408, 521, 547, 633, 659, 735, 765, 789, 913, 943, 967, 1045, 1062, 1086, 1260, 1517, 1864], '3Hyde': [409, 548, 660, 1046, 1797], 'R.J.': [410, 549, 661, 1047, 1129, 1798], 'Membr.': [418, 557, 669, 1055, 1137, 1806], 'Biol.': [419, 558, 670, 751, 799, 929, 977, 1056, 1072, 1138, 1246, 1525, 1745, 1807, 1880], '2001;': [420, 559, 671, 1057, 1139, 1274, 1316, 1358, 1808], '18:': [421, 560, 672, 1058, 1140, 1809], '53-63Crossref': [422, 561, 673, 1059, 1141, 1810], 'same': [427, 1286], 'transport': [428, 576, 592, 826, 1018], 'mechanisms': [429], 'function': [430, 584], 'drug': [432, 1341], 'mediate': [435], 'synthetic': [439], 'analogs': [441], 'cancer': [444], '(and': [445], 'viral)': [446], 'chemotherapy': [447], 'also': [476, 993], 'control': [477], 'concentration': [480], 'adenosine': [482], 'vicinity': [485], 'its': [487, 1393], 'cell': [488, 691], 'surface': [489], 'receptors': [490], 'regulate': [492], 'processes': [493], 'neurotransmission': [496], 'cardiovascular': [498], 'activity': [499], '2Young': [522, 634], 'Adenosine': [565], 'itself': [566], 'clinically': [569], 'treat': [571], 'cardiac': [572], 'arrhythmias,': [573], 'inhibitors': [577], 'dipyridamole,': [580], 'dilazep,': [581], 'draflazine': [583], 'coronary': [586], 'vasodilators.': [587], 'In': [588, 1322, 1720], 'mammals,': [589], 'plasma': [590], 'nucleosides': [594, 1023], 'brought': [596], 'about': [597], 'concentrative,': [602], 'Na+-dependent': [603], '(CNT)1': [604], 'equilibrative,': [606], 'Na+-independent': [607], '(ENT)': [608], 'families': [611], 'CNTs': [677], 'expressed': [679], 'tissue-specific': [682], 'fashion;': [683], 'ENTs': [684, 1105], 'present': [686, 1125], 'most,': [688], 'possibly': [689], 'all,': [690], 'types.': [692], 'Two': [693], 'isoforms': [695], 'been': [697, 1416], 'rat': [702, 817], '(4Griffiths': [704, 882, 1164, 1833], 'Beaumont': [706, 884, 1166, 1835], 'N.': [707, 885, 1088, 1167, 1836], 'Yao': [708, 768, 886, 946, 1168, 1233, 1263, 1837, 1867], 'S.Y.M.': [709, 737, 769, 887, 915, 947, 1169, 1234, 1264, 1303, 1838, 1868], 'Sundaram': [710, 888, 1170, 1304, 1839], 'Boumah': [712, 890, 1172, 1841], 'Davies': [714, 892, 1174, 1843], 'A.': [715, 893, 1175, 1357, 1400, 1679, 1844, 1901], 'Kwong': [716, 894, 1176, 1845], 'F.Y.P.': [717, 895, 1177, 1846], 'Coe': [718, 896, 1178, 1847], 'I.R.': [719, 897, 1179, 1848], 'Nat.': [726, 904, 1186, 1855], '1997;': [728, 753, 782, 906, 931, 960, 1188, 1857], '3:': [729, 907, 1189, 1858], '89-93Crossref': [730, 908, 1190, 1859], '(358)': [733, 911, 1193, 1862], '5Yao': [736, 914], 'Ng': [738, 916, 1235, 1265, 1869], 'A.M.L.': [739, 917, 1236, 1266, 1870], 'Muzyka': [740, 918], 'W.R.': [741, 919], 'Griffiths': [742, 920, 1237, 1871], 'J.': [750, 781, 798, 928, 959, 976, 1071, 1096, 1245, 1315, 1524, 1681, 1743, 1879, 1905], 'Chem.': [752, 800, 930, 978, 1073, 1247, 1526, 1881], '272:': [754, 932], '28423-28430Abstract': [755, 933], '(196)': [763, 811, 941, 989, 1084], '6Griffiths': [766, 944], 'Abidi': [770, 948], 'F.': [771, 949, 1685], 'Phillips': [772, 950], 'S.E.V.': [773, 951], 'Biochem.': [780, 958, 1095, 1314, 1509, 1904], '328:': [783, 961], '739-743Crossref': [784, 962], '(226)': [787, 965], '7Crawford': [790, 968, 1063], 'C.R.': [791, 969, 1064], 'Patel': [792, 970, 1065], 'D.H.': [793, 971, 1066], 'Naeve': [794, 972, 1067], 'C.': [795, 973, 1068, 1398, 1691], 'Belt': [796, 974, 1069], 'J.A.': [797, 975, 1070], '1998;': [801, 979, 1074, 1248, 1882], '273:': [802, 980, 1075, 1249, 1883], '5288-5293Abstract': [803, 981, 1076], 'Human': [814], '(h)': [815], '(r)': [818], 'ENT1': [819], 'ENT2': [821], '(456–457': [822], 'both': [827], 'pyrimidine': [830], 'distinguished': [836], 'functionally': [837, 1420], 'difference': [840], 'sensitivity': [842, 996], 'inhibition': [844, 998, 1296], 'NBMPR:': [846], 'rENT1': [849, 1006], 'potently': [851], 'inhibited': [852], 'NBMPR': [854, 875, 1199], '(Kd': [855], '1–10': [856], 'nm)': [857], 'functional': [861, 879], 'designation': [862], 'equilibrative-sensitive': [863], '(es),': [864], 'while': [865], 'hENT2': [866, 1004, 1014], 'rENT2': [868, 1016, 1290], 'unaffected': [870], 'micromolar': [872], 'concentrations': [873], 'designationequilibrative-insensitive': [880], '(ei)': [881], 'They': [992], 'differ': [994], 'vasodilator': [1000, 1201], 'drugs': [1001], '(hENT1': [1002], '>': [1003, 1005], '=': [1007], 'rENT2)': [1008], 'ability': [1012], 'nucleobases': [1019], 'well': [1021], '8Osses': [1087], 'Pearson': [1089], 'Yudilevich': [1091], 'D.L.': [1092], 'Jarvis': [1093], 'S.M.': [1094, 1350], '1996;': [1097, 1527, 1771], '317:': [1098], '843-848Crossref': [1099], '(43)': [1102, 1911], 'widely': [1107], 'distributed': [1108], 'other': [1110, 1428], 'eukaryotes,': [1111], 'insects,': [1113], 'nematodes,': [1114], 'protozoa,': [1115, 1323], 'plants': [1118], 'do': [1120], 'not': [1121], 'appear': [1122], 'be': [1124, 1497], 'prokaryotes': [1127], '(3Hyde': [1128], 'predicted': [1146, 1656], 'family,': [1158], 'contains': [1159, 1381], 'putative': [1161, 1227, 1728], 'Binding': [1196], 'domains': [1197], 'drugs,': [1202], 'which': [1203, 1559], 'compete': [1204], 'permeant': [1206], 'substrate-binding': [1209], 'site': [1210], 'at': [1211], 'surface,': [1214], 'comprise': [1215], 'region': [1217], 'h/rENT1': [1220, 1610], '(amino': [1222], 'residues': [1224, 1489], '100–231)': [1225], 'encompassing': [1226], '3–6': [1230, 1426], '(9Sundaram': [1231], '21519-21525Abstract': [1250, 1884], '(98)': [1258, 1892], '10Sundaram': [1261], 'Biochemistry.': [1273], '40:': [1275], '8146-8151Crossref': [1276], '(50)': [1279], 'A': [1282, 1366, 1823], 'residue': [1283], 'structural': [1287, 1447], 'domain': [1288], '(Cys140)': [1291], 'responsible': [1293], 'substrate-protectable': [1295], 'PCMBS': [1301], '(11Yao': [1302], 'Chomey': [1306], 'E.G.': [1307], '353:': [1317], '387-393Crossref': [1318], 'mutations': [1324], 'Gly183': [1326], 'helix': [1329], '5': [1330], 'Leishmania': [1332], 'donovani': [1333], 'LdNT1.1': [1334], 'result': [1335], 'altered': [1337], 'substrate': [1338], 'specificity': [1339], 'resistance': [1342, 1377], 'tubercidin': [1344], '(12Vasudevan': [1345], 'G.': [1346, 1677], 'Ullman': [1347], 'B.': [1348, 1740, 1764], 'Landfear': [1349], 'Proc.': [1351], 'Natl.': [1352], 'Acad.': [1353], 'Sci.': [1354, 1770], 'U.': [1355], 'S.': [1356, 1506], '98:': [1359], '6092-6097Crossref': [1360], '(60)': [1363], 'mutant': [1367], 'form': [1368], 'TbAT1': [1370], 'from': [1371, 1583], 'Trypanosoma': [1372], 'brucei': [1373, 1374], 'confers': [1376], 'melaminophenyl': [1379], 'arsenicals': [1380], 'six': [1382], 'substitutions': [1385], 'different': [1387], 'loops': [1391, 1822], 'sequence': [1394, 1631, 1663, 1723], '(13Maser': [1395], 'P.': [1396, 1742, 1766], 'Sutterlin': [1397], 'Kralli': [1399], 'Kaminsky': [1401], 'R.': [1402, 1504, 1687, 1768], 'Science.': [1403], '285:': [1405], '242-244Crossref': [1406], '(222)': [1409], 'While': [1412], 'these': [1413], 'studies': [1414, 1454, 1607], 'successful': [1417], 'identifying': [1419], 'important': [1421], 'there': [1430], 'currently': [1432], 'no': [1433], 'based': [1435], 'model': [1436, 1638, 1668], 'topology.': [1439], 'Such': [1440], 'information': [1441], 'essential': [1443], 'provide': [1445, 1635], 'basis': [1448], 'further': [1450], 'molecular': [1451], 'mechanistic': [1453], 'function.': [1458], 'One': [1459], 'approach': [1460, 1758], 'test': [1462], 'two-dimensional': [1464], 'orientation': [1465], 'proteins': [1469], 'identify': [1472, 1575], 'N-glycosylation.': [1475], 'During': [1476], 'synthesis,': [1478], 'attachment': [1479], 'N-linked': [1481], 'oligosaccharides': [1482], 'nascent': [1484], 'polypeptide': [1485], 'occurs': [1486], 'on': [1487, 1551, 1698, 1782], 'Asn': [1488], 'motif': [1492], 'Asn-X-Ser/Thr,': [1493], 'where': [1494], 'X': [1495], 'can': [1496], 'any': [1498], 'Pro': [1502], '(14Kornfeld': [1503], 'Kornfeld': [1505], 'Annu.': [1507], 'Rev.': [1508], '1985;': [1510], '54:': [1511], '631-664Crossref': [1512], '(3779)': [1515], '15Shakin-Eshleman': [1518], 'S.H.': [1519], 'Spitalnik': [1520], 'S.L.': [1521], 'Kasturi': [1522], 'L.': [1523], '271:': [1528], '6363-6366Abstract': [1529], '(256)': [1537], 'Due': [1540], 'strict': [1542], 'compartmentalization': [1543], 'enzymes,': [1545], 'N-glycosylation': [1546, 1585, 1601], 'carried': [1548], 'out': [1549], 'exclusively': [1550], 'luminal': [1553], 'side': [1554, 1566], 'endoplasmic': [1557], 'reticulum,': [1558], 'topologically': [1561], 'equivalent': [1562], 'protein.': [1569, 1626], 'Thus,': [1570], 'it': [1571], 'possible': [1573], 'exofacial': [1576], 'endofacial': [1578], 'profile.': [1586], 'Here,': [1587], 'we': [1588], 'Xenopus': [1594], 'engineered': [1600], 'erythrocyes': [1612], 'ventricular': [1614], 'myocytes': [1615], 'prototypical': [1623], 'When': [1627], 'combined': [1628], 'computer-based': [1630], 'analyses,': [1632], 'results': [1634], 'unified': [1637], 'eukaryotic': [1644], 'transporters.': [1647], 'locations': [1649], 'were': [1655, 1725, 1780, 1828], 'analysis': [1658], 'using': [1664, 1731, 1914], 'hidden': [1666], 'Markov': [1667], 'procedure': [1669, 1734], 'Sonnhammeret': [1671], 'al.': [1672, 1762], '(16Sonnhammer': [1673], 'E.L.L.': [1674], 'von': [1675], 'Heijne': [1676], 'Krogh': [1678], 'Glasgow': [1680], 'Littlejohn': [1682], 'T.': [1683], 'Major': [1684], 'Lathrop': [1686], 'Sankoff': [1688], 'D.': [1689], 'Sensen': [1690], 'Proceedings': [1692], 'Sixth': [1695], 'International': [1696], 'Conference': [1697], 'Intelligent': [1699], 'Systems': [1700], 'Molecular': [1702], 'Biology.': [1703], 'AAAI': [1704], 'Menlo': [1706], 'Park,': [1707], 'CA1998:': [1708], '175-182Google': [1709], 'Scholar)': [1710, 1753, 1894, 1913], 'implemented': [1712], 'computer': [1715], 'program': [1716], 'TMHMM': [1717], '(version': [1718], '2.0).': [1719], 'addition,': [1721], 'multiple': [1722], 'alignments': [1724], 'analyzed': [1726], 'TMAP': [1733], 'Persson': [1736], 'Argos': [1738, 1741], '(17Persson': [1739], '1994;': [1746, 1906], '237:': [1747], '182-192Crossref': [1748], '(424)': [1751], 'neural': [1756], 'network': [1757], '(PHDhtm)': [1759], 'Rostet': [1761], '(18Rost': [1763], 'Fariselli': [1765], 'Casadio': [1767], 'Protein': [1769], '1704-1718Crossref': [1773], '(533)': [1776], 'Analyses': [1779], 'performed': [1781], '34': [1784], 'listed': [1791], 'Table': [1793], 'I': [1794], 'Ref.': [1796], 'Scholar.': [1813], 'single': [1815], 'mutants': [1816], 'N48Q,': [1817], 'N277Q,': [1818], 'N288Q': [1820], '(putative': [1821], 'andH': [1824], 'Fig.': [1826], '1)': [1827], 'generated': [1829], 'plasmid': [1831], 'pKS-hENT1': [1832], '9Sundaram': [1865], 'PCR-based': [1897], 'megaprimer': [1898], 'method': [1899], '(19Sivaprasadarao': [1900], 'Findlay': [1902], 'J.B.C.': [1903], '300:': [1907], '437-442Crossref': [1908], 'Pfu': [1915], 'DNA': [1916], 'polymerase.': [1917]}, 'cited_by_api_url': 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