Publication Information

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309, 405, 416, 452, 510, 599, 634, 793, 848, 906, 1023, 1808, 1843, 2702, 2876, 2946, 3076, 3251, 4074, 4325, 5507], 'last': [91], 'several': [92, 514, 2581, 3272], 'years': [93], 'have': [94, 2133, 2468, 5745, 5805], 'witnessed': [95], 'an': [96, 191, 626, 2491, 2815, 2886, 3561], 'explosion': [97], 'in': [98, 122, 132, 178, 193, 248, 339, 351, 523, 728, 807, 898, 918, 943, 1170, 1227, 1383, 1554, 1602, 1612, 1679, 1923, 1962, 1989, 2270, 2490, 2710, 2814, 2997, 3003, 3083, 3220, 3311, 3560, 3632, 4759, 4773, 4925, 4976, 5019, 5049, 5124, 5143, 5235, 5315, 5365, 5519, 5575, 5687, 5690, 5765], 'the': [99, 105, 118, 140, 149, 155, 296, 303, 316, 333, 340, 347, 358, 388, 394, 400, 413, 423, 458, 473, 498, 503, 520, 560, 604, 618, 638, 725, 749, 787, 799, 886, 894, 1000, 1032, 1188, 1228, 1295, 1426, 1596, 1613, 1620, 1662, 1668, 1781, 1790, 2344, 2407, 2474, 2481, 2488, 2494, 2596, 2627, 2898, 3044, 3091, 3130, 3189, 3221, 3254, 3304, 3334, 3337, 3344, 3391, 3414, 3781, 3804, 3901, 4060, 4068, 4238, 4395, 4432, 4494, 4562, 4760, 4805, 4885, 4940, 4950, 4977, 5232, 5287, 5429, 5576, 5582, 5614, 5641, 5653, 5715, 5722, 5824, 5834, 5840], 'published': [100, 4560], 'literature': [101], 'on': [102, 1004, 2578, 2626, 3135, 3330, 4561, 4570], 'two': [103, 661, 1562, 2175, 2950, 3306, 3894, 4776], 'topics,': [104], 'pathways': [106, 130, 4069, 4912, 5284, 5509, 5752, 5841, 5886], 'that': [107, 438, 467, 939, 996, 1381, 1592, 1733, 2097, 2507, 2669, 3008, 3568, 3756, 3780, 3825, 5140, 5283, 5369, 5613, 5757, 5818], 'transduce': [108], 'signals': [110, 5319], 'to': [111, 124, 147, 190, 240, 295, 301, 332, 398, 410, 422, 437, 457, 519, 537, 573, 622, 706, 723, 748, 798, 804, 893, 941, 968, 1097, 1294, 1301, 1385, 1604, 1610, 1812, 1964, 1991, 2032, 2108, 2176, 2181, 2240, 2343, 2406, 2471, 2509, 2848, 3090, 3593, 3634, 3827, 4053, 4071, 4528, 4930, 5055, 5317, 5363, 5510, 5515, 5656, 5659, 5753, 5767, 5888], 'their': [112, 1104], 'intracellular': [113, 474, 4763], 'targets': [114, 5749], 'modification': [116, 5819, 5830], 'core': [119], 'translational': [120, 4926, 5349], 'apparatus': [121], 'response': [123, 1603, 1963, 1990, 3633, 5316, 5766], 'these': [125, 129, 729, 2949, 3308, 5010], 'signals.': [126], 'Most': [127, 2505], 'result': [131, 2182, 2523, 3310], 'cell': [133, 136, 150, 171, 5020, 5023, 5144, 5168], 'division.': [137, 172], 'Synthesis': [138], 'entire': [141], 'complement': [142], 'proteins': [144, 158, 580, 639, 858, 1003, 4983, 5017, 5170], 'is': [145, 168, 408, 420, 442, 667, 702, 746, 779, 796, 829, 854, 928, 961, 991, 1180, 1192, 1292, 1337, 1497, 1665, 1674, 1728, 1734, 1787, 1819, 1853, 1872, 1957, 1987, 2291, 2395, 2434, 2624, 2679, 2706, 2880, 2954, 3000, 3011, 3047, 3079, 3099, 3138, 3141, 3257, 3323, 3570, 3630, 3783, 3802, 3838, 3866, 4078, 4094, 4429, 4730, 5370, 5550, 5557, 5566, 5712, 5816], 'necessary': [146], 'double': [148], 'size,': [151], 'but': [152, 1226, 1430, 2104, 2516, 2996, 3408, 3685, 4065, 4091, 4290, 4403, 5052, 5562, 5590], 'synthesis': [153, 205, 1636, 3085, 3137, 3559, 3600, 4436, 4772, 5513, 5518, 5549, 5556, 5565, 5589, 5593, 5628, 5689, 5711, 5846, 5891], 'so-called': [156], '“growth-regulated”': [157], '(1Baserga': [159], 'R.': [160, 1047, 1239, 1480, 2277, 2378, 2557, 2721, 2727, 2861, 3423, 3444, 3574, 3604, 3610, 3689, 4628, 4742, 5174, 5528, 5595, 5773, 5860], 'Cancer': [161], 'Res.': [162], '1990;': [163, 4681, 4698], '50:': [164], '6769-6771PubMed': [165], 'Google': [166, 287, 377, 492, 556, 597, 699, 742, 775, 824, 846, 882, 958, 988, 1021, 1057, 1085, 1133, 1166, 1224, 1258, 1288, 1333, 1370, 1405, 1477, 1494, 1522, 1551, 1654, 1696, 1725, 1759, 1778, 1806, 1841, 1869, 1919, 1952, 1984, 2026, 2053, 2087, 2128, 2164, 2211, 2235, 2267, 2288, 2337, 2370, 2391, 2430, 2458, 2550, 2573, 2660, 2700, 2746, 2766, 2788, 2811, 2843, 2874, 2921, 2944, 2994, 3036, 3074, 3127, 3176, 3212, 3249, 3301, 3386, 3439, 3460, 3497, 3516, 3539, 3588, 3627, 3657, 3680, 3705, 3728, 3754, 3777, 3887, 3927, 3955, 3979, 4025, 4047, 4117, 4159, 4177, 4205, 4233, 4270, 4288, 4323, 4364, 4392, 4426, 4466, 4492, 4523, 4554, 4605, 4626, 4639, 4671, 4688, 4705, 4725, 4756, 4840, 4909, 4969, 5006, 5042, 5080, 5102, 5119, 5164, 5190, 5221, 5253, 5278, 5344, 5389, 5412, 5457, 5505, 5544, 5609, 5679, 5708, 5786, 5802, 5882], 'Scholar)': [167, 1259, 1289, 1523, 1760, 1920, 2268, 2551, 2767, 3440, 3461, 3498, 3517, 3540, 3681, 3755, 3864, 3928, 4289, 4467, 5191, 5222, 5254, 5458, 5803], 'needed': [169, 2680], 'for': [170, 346, 497, 581, 650, 1847, 1890, 2273, 2820, 3082, 4949, 4981, 5483, 5638, 5750, 5842, 5849, 5852], 'This': [173, 658, 744, 926, 1622, 2393, 2622, 3038, 3096, 3320, 5414, 5611, 5809], 'article': [174], 'summarizes': [175], 'recent': [176, 3215], 'advances': [177], 'our': [179], 'understanding': [180], 'how': [182], 'a': [183, 238, 429, 448, 464, 507, 524, 631, 931, 935, 992, 1729, 1893, 2094, 2271, 2301, 2311, 2401, 2522, 2587, 2670, 3142, 3153, 3312, 3683, 3962, 4129, 4936, 5013, 5058, 5131, 5366, 5466, 5480, 5684, 5768], 'single': [184, 5769], 'mitogenic': [185, 5059], 'stimulus': [186], 'can': [187, 245, 500, 1557, 5522, 5892], 'simultaneously': [188], 'lead': [189, 2508], 'increase': [192, 2816], 'both': [194, 671, 913, 1183, 1232, 1440, 1605, 2299, 3399, 3905, 5236, 5471], 'global': [195], 'growth-regulated': [197, 5302, 5516, 5634], 'synthesis.': [199, 1672, 4572], 'three': [201], 'stages': [202], 'are': [206, 391, 535, 578, 603, 672, 908, 1061, 1099, 1231, 1373, 1413, 1422, 1436, 2851, 3268, 3821, 4974, 5046, 5141, 5311, 5361], 'catalyzed': [207, 443], 'by': [208, 384, 393, 412, 425, 428, 444, 674, 704, 752, 781, 802, 831, 852, 856, 890, 965, 1063, 1101, 1103, 1182, 1298, 1339, 1343, 1418, 1529, 1559, 1677, 1736, 1789, 1821, 1874, 1892, 1927, 1994, 2186, 2293, 2300, 2310, 2397, 2437, 2483, 2503, 2531, 2580, 2632, 2675, 2768, 2883, 2962, 3052, 3271, 3325, 3389, 3413, 3803, 3840, 3893, 3904, 4437, 4808, 4814, 4846, 4853, 5291, 5373, 5721], 'initiation,': [209], 'elongation,': [210], 'release': [212], 'factors': [213, 311, 390, 456, 1993, 2467, 3256, 3983, 5762, 5822], '(Ref.': [214, 479], '2Merrick': [215], 'W.C.': [216, 267], 'Hershey': [217, 219, 256, 1568, 2603, 3350, 4782, 4863, 5088, 5774], 'J.W.B.': [218, 220, 257, 1569, 2604, 3351, 4783, 4864, 5089, 5775], 'Mathews': [221, 264, 1570, 2605, 3352, 4784, 4865], 'M.B.': [222, 265, 1571, 2606, 3353, 4785, 4866], 'Sonenberg': [223, 270, 1572, 2148, 2381, 2607, 2864, 2910, 2935, 3354, 3648, 3669, 3737, 3765, 4452, 4474, 4505, 4543, 4786, 4867, 5065, 5444], 'N.': [224, 271, 1008, 1312, 1573, 1932, 2149, 2382, 2608, 2865, 2911, 2936, 3355, 3649, 3670, 3738, 3766, 3768, 4308, 4453, 4475, 4506, 4542, 4544, 4787, 4868, 5066, 5206, 5239, 5441, 5445, 5694], 'Translational': [225, 1574, 2609, 3356, 4788, 4869], 'Control.': [226, 1575, 2610, 3357, 4789, 4870], 'Cold': [227, 232, 1576, 1581, 2611, 2616, 3358, 3363, 4790, 4795, 4871, 4876], 'Spring': [228, 233, 1577, 1582, 2612, 2617, 3359, 3364, 4791, 4796, 4872, 4877], 'Harbor': [229, 1578, 2613, 3360, 4792, 4873], 'Laboratory': [230, 1579, 2614, 3361, 4793, 4874], 'Press,': [231, 1580, 2615, 3362, 4794, 4875], 'Harbor,': [234, 1583, 2618, 3365, 4797, 4878], 'NY1996:': [235, 1584, 2619, 3366, 4798, 4879], '31-69Google': [236], 'Scholar;': [237, 493], 'guide': [239], 'current': [241], 'previous': [243], 'nomenclature': [244], 'be': [246, 501, 2033, 2501, 4072, 5523, 5657, 5893], 'found': [247, 2107, 4975], 'Ref.': [249, 3421, 5856], '3Clark': [250], 'B.F.C.': [251], 'Grunberg-Manago': [252], 'M.': [253, 541, 1644, 1936, 2038, 2058, 2323, 2356, 2797, 3022, 3477, 3479, 3487, 3845, 4000, 4214, 4373, 4471, 4536, 4896], 'Gupta': [254], 'N.K.': [255], 'Hinnebusch': [258], 'A.G.': [259, 2535], 'Jackson': [260], 'R.J.': [261, 1115, 1148, 1352], 'Maitra': [262], 'U.': [263, 1750, 1910, 2202, 2564, 2834, 3485, 3745, 4901, 5071, 5260, 5403, 5873], 'Merrick': [266], 'Rhoads': [268, 1485, 2730, 2828, 3428, 3449, 3579, 3609, 3694, 4747, 5086, 5179, 5533, 5600], 'R.E.': [269, 1486, 2731, 2829, 3429, 3450, 3580, 3695, 4748, 5087, 5180, 5534, 5601], 'Spremulli': [272], 'L.': [273, 1041, 1111, 1136, 1237, 1348, 1456, 2056, 3936, 4546, 5107], 'Trachsel': [274], 'H.': [275, 1142, 2036, 2070, 2145, 2221, 2374, 2857, 3471, 3483, 4300, 4302, 5858], 'Voorma': [276, 4005], 'H.O.': [277, 4006], 'Biochimie': [278], '(': [279], 'Paris': [280], ').': [281], '1996;': [282, 982, 1772, 1800, 1860, 2419, 2649, 3118, 3433, 3454, 3699, 3718, 3748, 3973, 4594, 5184, 5272, 5383, 5538], '78:': [283], '11-12Crossref': [284], 'Scopus': [285, 375, 490, 554, 595, 697, 740, 773, 822, 844, 880, 956, 986, 1019, 1055, 1131, 1164, 1222, 1256, 1286, 1331, 1368, 1403, 1475, 1520, 1549, 1652, 1694, 1723, 1757, 1776, 1804, 1839, 1867, 1917, 1950, 1982, 2024, 2085, 2126, 2162, 2209, 2233, 2265, 2286, 2335, 2368, 2389, 2428, 2456, 2548, 2571, 2658, 2698, 2744, 2764, 2786, 2809, 2841, 2872, 2919, 2942, 2992, 3034, 3125, 3174, 3210, 3247, 3299, 3384, 3437, 3458, 3495, 3514, 3537, 3625, 3655, 3678, 3703, 3726, 3752, 3775, 3925, 3977, 4023, 4045, 4115, 4157, 4175, 4203, 4231, 4268, 4286, 4321, 4362, 4390, 4424, 4490, 4521, 4552, 4603, 4624, 4637, 4669, 4838, 4907, 4967, 5004, 5040, 5078, 5117, 5162, 5188, 5219, 5276, 5342, 5387, 5410, 5455, 5503, 5542, 5677, 5880], '(41)': [286], 'Scholar).': [288, 378, 557, 598, 700, 743, 776, 825, 847, 883, 959, 989, 1022, 1058, 1086, 1167, 1371, 1406, 1495, 1552, 1586, 1655, 1726, 1779, 1807, 1842, 1953, 1985, 2027, 2088, 2129, 2165, 2236, 2289, 2338, 2392, 2431, 2459, 2574, 2621, 2661, 2701, 2844, 2875, 2945, 3037, 3075, 3128, 3213, 3250, 3302, 3387, 3589, 3628, 3888, 3980, 4048, 4118, 4234, 4324, 4393, 4427, 4555, 4726, 4757, 4800, 4841, 4881, 4910, 5007, 5043, 5120, 5165, 5279, 5345, 5413, 5506, 5545, 5610, 5709], 'A': [289, 3214], 'ternary': [290], 'complex': [291, 307, 795, 2589, 2888, 2899, 3078], 'eIF2·GTP·Met-tRNAi1': [293], 'binds': [294, 940, 1609, 2342], '40': [297, 3224], 'S': [298, 305, 335, 342, 396, 402, 3093, 3182, 3225], 'subunit': [300, 397, 933, 938, 2629], 'form': [302, 399], '43': [304, 334, 3092], '(Fig.1).': [308], 'eIF4': [310], 'plus': [312], 'poly(A)-binding': [313, 5357], 'recognize': [315], '5′-terminal': [317], 'cap': [318], 'or': [319, 506, 811, 2172, 2306, 2477, 2496, 4327, 5296], '3′-terminal': [320], 'poly(A)': [321], 'tract': [322, 3155], 'mRNA,': [324], 'unwind': [325], 'mRNA': [326, 2703, 3089, 3228, 5477], 'secondary': [327, 5138, 5307], 'structure,': [328], 'transfer': [330], 'it': [331, 892, 1336, 5815], 'complex,': [337, 2493, 3046], 'resulting': [338, 521, 2813], '48': [341], 'complex.': [344, 404, 3095], 'Scanning': [345], 'first': [348, 417, 3252], 'codon': [350], 'good': [352], 'sequence': [353, 4947], 'context': [354, 4948], 'requires': [355, 4334, 5223], 'eIF4A': [356], 'presence': [359, 4396, 4941], 'eIF1': [361], 'eIF1A': [363], '(4Pestova': [364], 'T.V.': [365], 'Borukhov': [366], 'S.I.': [367], 'Hellen': [368], 'C.U.T.': [369], 'Nature.': [370, 839, 1647, 2937, 3650, 5112], '1998;': [371, 545, 591, 736, 764, 818, 840, 871, 952, 1051, 1160, 1247, 1322, 1545, 1690, 1714, 1753, 1830, 1913, 1946, 2049, 2153, 2205, 2452, 2983, 3238, 3491, 3510, 3616, 3771, 4014, 4106, 4148, 4171, 4194, 4259, 4282, 4353, 4415, 4512, 4548, 4660, 4829, 5000, 5210, 5673, 5876], '394:': [372], '854-859Crossref': [373], 'PubMed': [374, 489, 553, 594, 696, 739, 772, 821, 843, 879, 955, 985, 1018, 1054, 1084, 1130, 1163, 1221, 1255, 1285, 1330, 1367, 1402, 1474, 1493, 1519, 1548, 1651, 1693, 1722, 1756, 1775, 1803, 1838, 1866, 1916, 1949, 1981, 2023, 2052, 2084, 2125, 2161, 2208, 2232, 2264, 2285, 2334, 2367, 2388, 2427, 2455, 2547, 2570, 2657, 2743, 2763, 2785, 2808, 2840, 2871, 2918, 2941, 2991, 3033, 3073, 3124, 3173, 3209, 3246, 3298, 3383, 3436, 3457, 3494, 3513, 3587, 3624, 3654, 3677, 3702, 3751, 3774, 3886, 3924, 3954, 3976, 4022, 4044, 4114, 4156, 4174, 4202, 4230, 4267, 4285, 4320, 4361, 4389, 4423, 4465, 4489, 4520, 4551, 4602, 4623, 4636, 4668, 4687, 4704, 4724, 4755, 4837, 4966, 5003, 5039, 5077, 5101, 5116, 5161, 5187, 5218, 5275, 5341, 5386, 5409, 5454, 5502, 5541, 5608, 5676, 5785, 5801, 5879], '(320)': [376], 'Then': [379], 'eIF5': [380], 'stimulates': [381, 3398, 3556, 3891, 5128], 'GTP': [382, 432, 449, 851], 'hydrolysis': [383, 433, 450, 849], 'eIF2,': [385], 'after': [386, 5057, 5621], 'which': [387, 608, 783, 1421, 1871, 2179, 2499, 4567, 4973, 5285, 5580], 'replaced': [392], '60': [395], '80': [401, 3181], 'released': [406, 1601], 'eIF2·GDP': [407], 'recycled': [409], 'eIF2·GTP': [411], 'GEF': [414, 777, 2623], 'eIF2B.': [415], 'elongator': [418], 'aminoacyl-tRNA': [419], 'brought': [421], 'A-site': [424], 'eEF1,': [426, 5742], 'followed': [427], 'cycle': [430, 5024], 'analogous': [436], 'eIF2.': [440], 'Translocation': [441], 'eEF2,': [445, 5355], 'again': [446], 'with': [447, 786, 1091, 1667, 1997, 2590, 2889, 3184, 3836, 5009, 5135, 5229, 5304, 5525], 'cycle.': [451], 'binding': [453, 803, 967, 1300, 2245, 2478, 3087], 'RTKs': [462, 585, 944, 1184, 1606, 3986], 'causes': [463, 2584, 2895, 4057, 4442, 4888, 5650, 5683], 'conformational': [465], 'change': [466], 'induces': [468], 'oligomerization': [469], 'activation': [471, 1669, 1816, 3145, 5472, 5649], 'Tyr': [476, 642, 916], '5Marshall': [480], 'C.J.': [481, 760, 867, 1068], 'Cell.': [482, 589, 734, 816, 950, 1011, 1488, 2329, 2362, 2803, 3028, 3431, 3452, 3489, 3582, 3697, 4750, 5182, 5271, 5449, 5536, 5603], '1995;': [483, 688, 1012, 1648, 2735, 2755, 5113, 5250, 5705], '80:': [484, 1013], '179-185Abstract': [485], 'Full': [486, 548, 550, 691, 693, 767, 769, 874, 876, 1015, 1081, 1216, 1218, 1250, 1252, 1280, 1282, 1325, 1327, 1399, 1469, 1471, 1514, 1516, 1717, 1719, 1833, 1835, 1863, 1976, 1978, 2018, 2020, 2079, 2081, 2122, 2156, 2158, 2422, 2424, 2542, 2544, 2652, 2654, 2738, 2740, 2758, 2760, 2986, 2988, 3070, 3121, 3204, 3206, 3241, 3243, 3293, 3295, 3619, 3621, 3721, 3723, 3883, 3919, 3921, 3951, 4017, 4019, 4039, 4041, 4109, 4111, 4151, 4153, 4197, 4199, 4225, 4227, 4262, 4264, 4315, 4317, 4356, 4358, 4384, 4386, 4418, 4420, 4462, 4484, 4486, 4515, 4517, 4597, 4599, 4663, 4665, 4684, 4701, 4721, 4832, 4834, 5098, 5213, 5215, 5336, 5338, 5782, 5798], 'Text': [487, 549, 551, 692, 694, 768, 770, 875, 877, 1016, 1082, 1217, 1219, 1251, 1253, 1281, 1283, 1326, 1328, 1400, 1470, 1472, 1515, 1517, 1718, 1720, 1834, 1836, 1864, 1977, 1979, 2019, 2021, 2080, 2082, 2123, 2157, 2159, 2423, 2425, 2543, 2545, 2653, 2655, 2739, 2741, 2759, 2761, 2987, 2989, 3071, 3122, 3205, 3207, 3242, 3244, 3294, 3296, 3620, 3622, 3722, 3724, 3884, 3920, 3922, 3952, 4018, 4020, 4040, 4042, 4110, 4112, 4152, 4154, 4198, 4200, 4226, 4228, 4263, 4265, 4316, 4318, 4357, 4359, 4385, 4387, 4419, 4421, 4463, 4485, 4487, 4516, 4518, 4598, 4600, 4664, 4666, 4685, 4702, 4722, 4833, 4835, 5099, 5214, 5216, 5337, 5339, 5783, 5799], 'PDF': [488, 552, 695, 771, 878, 1017, 1083, 1220, 1254, 1284, 1329, 1401, 1473, 1518, 1721, 1837, 1865, 1980, 2022, 2083, 2124, 2160, 2426, 2546, 2656, 2742, 2762, 2990, 3072, 3123, 3208, 3245, 3297, 3623, 3725, 3885, 3923, 3953, 4021, 4043, 4113, 4155, 4201, 4229, 4266, 4319, 4360, 4388, 4422, 4464, 4488, 4519, 4601, 4667, 4686, 4703, 4723, 4836, 5100, 5217, 5340, 5784, 5800], '(4245)': [491], 'Fig.': [494, 3542, 5460], '2).': [495, 3543, 5461], 'Substrates': [496], 'either': [502], 'RTK': [504], 'itself': [505], 'separate': [508, 529], 'RKS.': [509], 'SH2': [511, 662], 'domains': [512, 1107], 'different': [515, 2582, 5727, 5731], 'signaling': [516, 531, 2526, 5421, 5425], 'molecules': [517, 730], 'dock': [518], 'Tyr(P)s': [522, 806, 942], 'sequence-specific': [525], 'manner,': [526], 'thereby': [527, 2594], 'activating': [528, 3565], 'downstream': [530, 568, 582, 834, 1499, 5432], 'cascades.': [532], 'These': [533, 577, 1087, 2237, 5044, 5280, 5346], 'coupled': [536], 'heterotrimeric': [538], 'G-proteins': [539], '(6Vaughan': [540], 'J.': [542, 685, 761, 838, 868, 979, 981, 1075, 1156, 1195, 1210, 1244, 1274, 1319, 1460, 1463, 1508, 1708, 1711, 1827, 1970, 2012, 2048, 2072, 2073, 2150, 2260, 2281, 2384, 2416, 2451, 2536, 2646, 2725, 2732, 2752, 2781, 2867, 2980, 3064, 3169, 3198, 3235, 3287, 3378, 3613, 3715, 3857, 3859, 3877, 3913, 3942, 3945, 3972, 4011, 4033, 4103, 4145, 4170, 4190, 4191, 4216, 4219, 4255, 4256, 4281, 4309, 4350, 4375, 4378, 4412, 4456, 4478, 4509, 4591, 4619, 4632, 4657, 4678, 4695, 4715, 4826, 4959, 5032, 5064, 5092, 5109, 5111, 5154, 5207, 5248, 5330, 5382, 5498, 5672, 5703, 5776, 5792], 'Biol.': [543, 686, 762, 869, 1076, 1211, 1245, 1275, 1320, 1464, 1489, 1509, 1712, 1828, 1971, 2013, 2074, 2151, 2330, 2363, 2417, 2537, 2647, 2733, 2753, 2804, 2981, 3029, 3065, 3199, 3236, 3288, 3432, 3453, 3490, 3583, 3614, 3698, 3716, 3878, 3914, 3946, 4012, 4034, 4104, 4146, 4192, 4220, 4257, 4310, 4351, 4379, 4413, 4457, 4479, 4510, 4592, 4658, 4679, 4696, 4716, 4751, 4827, 4962, 5035, 5093, 5157, 5183, 5208, 5270, 5331, 5450, 5537, 5604, 5777, 5793], 'Chem.': [544, 687, 763, 870, 1077, 1212, 1246, 1276, 1321, 1465, 1510, 1713, 1829, 1972, 2014, 2075, 2152, 2418, 2538, 2648, 2734, 2754, 2982, 3066, 3200, 3237, 3289, 3615, 3717, 3879, 3915, 3947, 4013, 4035, 4105, 4147, 4193, 4221, 4258, 4311, 4352, 4380, 4414, 4458, 4480, 4511, 4593, 4659, 4680, 4697, 4717, 4828, 5094, 5209, 5332, 5778, 5794], '273:': [546, 765, 872, 1248, 1323, 1715, 1831, 2154, 2984, 3239, 3617, 4015, 4107, 4149, 4195, 4260, 4354, 4416, 4513, 4661, 4830, 5211], '17297Abstract': [547], '(16)': [555], 'Dissociation': [558], 'G-protein': [561, 745], 'subunits': [562, 3226, 3267], 'activates': [563, 885, 902, 1027, 1036, 1439, 4497], 'AC,': [564], 'PLC,': [565], 'other': [567, 2677, 3823], 'effectors.': [569], 'PLC': [570], 'hydrolyzes': [571], 'PtdIns(4,5)P2': [572], 'DAG': [574], 'Ins(1,4,5)P3.': [576], 'docking': [579, 648, 705], 'effectors': [583], '(7White': [586, 731, 813, 947], 'M.F.': [587, 732, 814, 948, 1484, 3427, 3448, 3578, 3693, 3944, 4746, 5178, 5266, 5532, 5599], 'Mol.': [588, 733, 815, 949, 1487, 2328, 2361, 2802, 3027, 3430, 3451, 3488, 3581, 3696, 4749, 5181, 5269, 5448, 5535, 5602], 'Biochem.': [590, 735, 817, 951, 1394, 1858, 2117, 2450, 2691, 3116, 3379, 3530, 4169, 4280, 4960, 5033, 5155], '182:': [592, 737, 819, 953], '3-11Crossref': [593, 738, 820, 954], '(625)': [596, 741, 823, 957], 'best': [600, 3392], 'studied': [601], 'RKS': [602, 946, 3824], 'substrates,': [607], 'include': [609, 4935], 'IRS-1,': [610, 716, 808, 5579], 'IRS-2,': [611, 717, 809], 'IRS-3,': [612], 'Gab-1,': [613], 'p62DOK.': [615], 'Members': [616], 'IRS': [619], 'family': [620], 'bind': [621, 1096, 2109, 2849], 'via': [625, 1524, 2304, 2314, 3327, 3961, 4818, 4857], 'NH2-terminal': [627], 'PH': [628, 1106, 1307], 'Tyr(P)-binding': [632], 'domain.': [633], 'COOH-terminal': [635, 753, 1105, 1883, 2405], 'portions': [636], 'contain': [640], 'numerous': [641, 1625, 3822], 'phosphorylation': [643, 1025, 1034, 1340, 1526, 1629, 1814, 1848, 1876, 1891, 1924, 2003, 2185, 2294, 2484, 2510, 2518, 2672, 2892, 2961, 3010, 3134, 3219, 3326, 3335, 3342, 3404, 3868, 3896, 4088, 4124, 4329, 4443, 4530, 4576, 4815, 4854, 4890, 5292], 'sites.': [644, 1880], 'IRS-1': [645, 3416, 3784, 3806], 'alone': [646, 5416], 'provides': [647], 'sites': [649, 1884, 3051], 'PI3-K,': [651, 5622], 'SH-PTP2,': [652], 'Grb-2,': [653], 'Fyn,': [654], 'Nck,': [655], 'Crk.': [657], 'phosphatase': [659], 'contains': [660, 2400], 'domains,': [663], 'enzyme': [665, 1663], 'activity': [666, 778, 1786, 1845, 2476, 3410, 4075, 4093], 'maximally': [668], 'activated': [669, 703, 963, 1100, 1181, 1338, 1414, 1498, 1735, 1873, 1958, 1988, 2292, 2396, 2436, 5691], 'when': [670, 5814], 'occupied': [673], 'Tyr(P)-containing': [675], 'peptides': [676], '(8Pluskey': [677], 'S.': [678, 1201, 1751, 1911, 2042, 2066, 2147, 2203, 2372, 2565, 2639, 2835, 2855, 3159, 3230, 3475, 3746, 3843, 4477, 4532, 4584, 4902, 5072, 5404, 5437, 5488, 5874], 'Wandless': [679], 'T.J.': [680], 'Walsh': [681], 'C.T.': [682], 'Shoelson': [683], 'S.E.': [684, 5202], '270:': [689, 2736, 2756], '2897-2900Abstract': [690], '(242)': [698], 'SH-PTP2': [701, 812, 3592], 'EGF': [707, 3998], 'receptor,': [708, 712, 715], 'platelet-derived': [709, 3991], 'c-kit,': [713], 'IRS-3': [719], 'may': [721, 2500, 3546, 5804], 'serve': [722], 'attenuate': [724], 'Tyr(P)': [726], 'signal': [727, 1026, 1035, 1428, 5060, 5616, 5771], 'bound': [747], 'plasma': [750, 800, 895, 1296], 'membrane': [751, 801, 1297], 'prenylation': [754], 'myristoylation': [756], '(9Vojtek': [757, 864], 'A.B.': [758, 865, 1121, 1146, 1358], 'Der': [759, 866], '19925-19928Abstract': [766, 873], '(499)': [774, 881], 'provided': [780], 'SOS,': [782], 'associates': [784], 'constitutively': [785, 1928, 3553, 5572], 'SH2-': [788], 'SH3-containing': [790], 'Grb-2.': [792], 'Grb-2·SOS': [794, 3809], 'recruited': [797, 5054, 5362, 5658], 'specific': [805], 'Shc,': [810], 'Another': [826], 'GEF,': [827], 'Ras-GEF,': [828], 'stimulated': [830, 855, 3839], 'Ca2+/calmodulin': [832], '(CaM)': [833], 'GPCR': [836, 1588, 4438], '(10Downward': [837], '396:': [841], '416-417Crossref': [842], '(36)': [845], 'Ras': [853, 3811], 'GTPase-activating': [857], 'such': [859, 4848], 'as': [860, 2093, 2244, 2521, 3041, 3865, 4063, 4849, 5748], 'p120GAP': [861], 'NF1': [863], 'Ras·GTP': [884, 969], 'Ser/Thr': [887, 1005, 1879], 'Raf-1': [889], 'recruiting': [891], 'membrane.': [896], 'Raf-1,': [897], 'turn,': [899], 'phosphorylates': [900, 997, 1762], 'MEK1': [903], 'MEK2.': [905], 'MEKs': [907], 'dual': [909, 993], 'specificity': [910, 994], 'kinases,': [911, 1090, 2238, 3273], 'phosphorylating': [912], 'Thr': [914], 'residues': [917, 1006], 'ERK1': [919, 1998, 2248, 2274, 2305], 'ERK2': [921], '(p42': [922], 'p44': [924], 'MAPKs).': [925], 'composed': [929, 3258], 'catalytic': [932, 2408], 'regulatory': [937, 2952, 5751], 'PI3-K': [960, 990, 1191, 1501, 3442, 3790, 4740], 'also': [962, 2309, 2341, 2435, 2519, 2881, 3890, 5312], 'synergistically': [964], 'direct': [966, 1299, 1525, 2184, 5481], '(11Rodriguez-Viciana': [970], 'P.': [971, 1154, 1207, 1458, 1503, 1541, 1642, 3606, 5243, 5698], 'Warne': [972], 'P.H.': [973, 1739, 1824], 'Vanhaesebroeck': [974], 'B.': [975, 1452, 2321, 2354, 2643, 2713, 2795, 3020, 4588], 'Waterfield': [976], 'M.D.': [977], 'Downward': [978], 'EMBO': [980, 2047, 2259, 2280, 2383, 2780, 2866, 3168, 3971, 4618, 4631, 5381, 5497], '15:': [983, 3974, 5384], '2442-2451Crossref': [984], '(501)': [987], 'PtdIns': [998], 'at': [999, 1092, 1171, 1341, 1374, 1527, 1560, 1659, 2170, 2295, 2664, 2673, 2708, 3049, 3101, 3106, 4774, 5560, 5618], '3-position': [1001], '(12Divecha': [1007], 'Irvine': [1009], 'R.F.': [1010, 1074], '269-278Abstract': [1014], '(590)': [1020], 'lipid': [1024], 'PDK': [1028, 1344, 3463, 3792], 'PKB,': [1030], 'MAPK': [1037], '(13Bondeva': [1038], 'T.': [1039, 1113, 1199, 1350, 2279, 2380, 2555, 2863, 2901, 2932, 3467, 3481, 3645, 3660, 4630], 'Pirola': [1040], 'Bulgarelli-Leva': [1042], 'G.': [1043, 1446, 1482, 1944, 2044, 2909, 3167, 3234, 3576, 3668, 3740, 3847, 4133, 4135, 4338, 4340, 4744, 5398, 5447, 5496, 5597], 'Rubio': [1044], 'I.': [1045, 1203, 3708, 5264, 5325, 5668], 'Wetzker': [1046, 1238], 'Wymann': [1048], 'M.P.': [1049], 'Science.': [1050, 1126, 1159, 1363, 1544, 1945, 2228, 2914, 3673], '282:': [1052], '293-296Crossref': [1053], '(302)': [1056], 'Both': [1059], 'activities': [1060], 'inhibited': [1062, 1788, 3324, 5372, 5551], 'wortmannin': [1064], 'LY294002': [1066], '(14Vlahos': [1067], 'Matter': [1069], 'W.F.': [1070], 'Hui': [1071], 'K.Y.': [1072], 'Brown': [1073], '1994;': [1078, 1396, 2567, 2837, 2915, 2938, 3651, 3674, 3948, 4459, 5406], '269:': [1079, 3949, 4460], '5241-5248Abstract': [1080], 'recently': [1088], 'discovered': [1089, 2034], 'least': [1093, 1172, 1375, 1561, 4775], 'four': [1094, 1173], 'isoforms,': [1095], 'PtdIns(3,4,5)P3': [1102, 1304], '(15Stokoe': [1108, 1345], 'D.': [1109, 1140, 1346, 3061, 3849, 3874, 5327], 'Stephens': [1110, 1347], 'Copeland': [1112, 1349], 'Gaffney': [1114, 1147, 1351], 'Reese': [1116, 1149, 1353], 'C.B.': [1117, 1150, 1354], 'Painter': [1118, 1143, 1355], 'G.F.': [1119, 1144, 1356], 'Holmes': [1120, 1145, 1357], 'McCormick': [1122, 1151, 1359], 'F.': [1123, 1152, 1360, 2141], 'Hawkins': [1124, 1157, 1361], 'P.T.': [1125, 1158, 1362], '1997;': [1127, 1213, 1277, 1364, 1466, 1490, 1511, 1973, 2119, 2229, 2261, 2282, 2539, 2694, 2782, 3170, 3201, 3290, 3533, 3584, 3916, 4481, 4620, 4633, 4752, 4904, 5451, 5499, 5605], '277:': [1128, 1365, 2230], '567-570Crossref': [1129, 1366], '(1054)': [1132, 1369], 'Scholar,': [1134, 1478, 1697, 2054, 2747, 2789, 2922, 3368, 3658, 3706, 3729, 4026, 4160, 4178, 4206, 4271, 4365, 4640, 5081, 5103, 5390, 5787], '16Stephens': [1135], 'Anderson': [1137], 'K.': [1138, 2009, 4180, 4182, 4208, 4212, 4218, 4245, 4247, 4367, 4371, 4377, 5241, 5696], 'Stokoe': [1139], 'Erdjument-Bromage': [1141], 'Tempst': [1153], 'Coadwell': [1155], '279:': [1161, 1947], '710-714Crossref': [1162], '(916)': [1165], 'PKB': [1168, 1291, 1678, 1737, 3465, 3569, 3758, 3794, 4243], 'exists': [1169], 'isoforms': [1174, 1377, 1432, 1444, 2132], '(α,': [1175, 1409], 'β1,': [1176], 'β2,': [1177], 'γ)': [1178, 1412], 'GPCR.': [1186], 'In': [1187, 2956, 3303, 4394], 'former': [1189, 3345], 'case,': [1190], 'involved': [1193, 3572, 5018, 5142], '(17Wijkander': [1194], 'Holst': [1196], 'L.S.': [1197, 3855, 4102, 4411], 'Rahn': [1198], 'Resjo': [1200], 'Castan': [1202], 'Manganiello': [1204], 'V.': [1205, 4030], 'Belfrage': [1206], 'Degerman': [1208], 'E.': [1209, 1682, 2729, 3232, 3502, 5321], '272:': [1214, 1278, 1467, 1512, 1974, 2540, 3202, 3291, 3917, 4482], '21520-21526Abstract': [1215], '(74)': [1223], 'Scholar),': [1225, 1334, 1870, 2812, 2995, 3177, 3778, 3956, 4493, 4524, 4606, 4672, 4689, 4706, 4970, 5680, 5883], 'latter,': [1229], 'there': [1230], 'PI3-K-dependent': [1233], '(18Murga': [1234], 'C.': [1235, 1314, 3163, 4188, 4253, 4540, 5394, 5492], 'Laguinge': [1236], 'Cuadrado': [1240], 'A.': [1241, 1454, 1565, 1752, 1912, 1938, 2204, 2217, 2254, 2566, 2749, 2775, 2836, 2907, 2924, 2928, 2967, 3347, 3637, 3641, 3666, 3747, 4538, 4613, 4644, 4779, 4860, 4903, 4955, 5028, 5062, 5073, 5150, 5200, 5323, 5405, 5443, 5666, 5875], 'Gutkind': [1242], 'J.S.': [1243], '19080-19085Abstract': [1249], '(295)': [1257, 4176, 4287], '-independent': [1261], '(19Moule': [1262], 'S.K.': [1263], 'Welsh': [1264, 4001], 'G.I.': [1265, 2637, 2682, 3521, 4002, 4582], 'Edgell': [1266], 'N.J.': [1267], 'Foulstone': [1268, 2685, 3524, 3967, 5377], 'E.J.': [1269, 2686, 3525, 3968, 5378], 'Proud': [1270, 2255, 2414, 2644, 2689, 2750, 2776, 2978, 3375, 3528, 3969, 4007, 4167, 4278, 4589, 4614, 4655, 5379], 'C.G.': [1271, 1856, 2256, 2415, 2645, 2690, 2751, 2777, 2979, 3114, 3376, 3529, 3970, 4008, 4168, 4279, 4590, 4615, 4656, 5380], 'Denton': [1272, 2448], 'R.M.': [1273, 2449, 4451], '7713-7719Abstract': [1279], '(226)': [1287], 'pathways.': [1290], 'targeted': [1293], 'PtdIns(3,4)P2': [1302], 'through': [1305, 3549, 3682, 3985, 4081, 4087, 4128, 4579, 4608, 4739, 5422, 5426, 5629, 5643], 'its': [1306, 1784, 2818, 4766], '(20Sable': [1309], 'C.L.': [1310], 'Filippa': [1311], 'Filloux': [1313], 'Hemmings': [1315, 1645, 1685, 1941, 3505], 'B.A.': [1316, 1646, 1686, 1942, 3506, 4821], 'Obberghen': [1317], 'E.V.': [1318], '29600-29606Abstract': [1324], '(50)': [1332], 'where': [1335], 'Thr-308': [1342], 'There': [1372, 3140], '10': [1376], 'PKC': [1379, 3282], '(α–ζ)': [1380], 'differ': [1382, 4923], 'responsiveness': [1384], 'phospholipids': [1386], 'Ca2+': [1388, 1590, 1618, 2441, 4764, 4803, 4845], '(21Dekker': [1389], 'L.V.': [1390], 'Parker': [1391, 1542], 'P.J.': [1392, 1543, 2223, 4298, 4306, 5091], 'Trends': [1393, 1857, 2116, 3115], 'Sci.': [1395, 1749, 1859, 1909, 2118, 2201, 2563, 2833, 3117, 3744, 4900, 5070, 5402, 5872], '19:': [1397, 2332, 2365, 2806, 3031], '73-77Abstract': [1398], '(920)': [1404], 'Classical': [1407], 'PKCs': [1408], 'β,': [1410, 3261], 'eventually': [1416], 'down-regulated': [1417], 'phorbol': [1419, 4565, 4734], 'esters,': [1420, 4566], 'structural': [1423], 'analogs': [1424], 'physiological': [1427], 'DAG,': [1429, 4569], 'atypical': [1431, 1443], '(λ': [1433], 'ζ)': [1435], 'not.': [1437], 'Insulin': [1438, 3889], 'classical': [1441], '(22Bandyopadhyay': [1445], 'Standaer': [1447], 'M.L.': [1448, 2825, 4144, 4349], 'Zhao': [1449, 2057], 'L.,': [1450], 'Yu,': [1451], 'Avignon': [1453], 'Galloway': [1455], 'Karnam': [1457], 'Moscat': [1459], 'Farese': [1461], 'R.V.': [1462], '2551-2558Abstract': [1468], '(276)': [1476], '23Mendez': [1479], 'Kollmorgen': [1481, 3575, 4743, 5596], 'White': [1483, 3426, 3447, 3577, 3611, 3692, 3943, 4745, 5177, 5531, 5598], '17:': [1491, 2050, 3585, 4753, 5452, 5606], '5184-5192Crossref': [1492, 3586, 4754, 5607], 'PKCζ': [1496, 3555, 5574], '(24Herrera-Velit': [1502], 'Knutson': [1504], 'K.L.': [1505], 'Reiner': [1506], 'N.E.': [1507], '16445-16452Abstract': [1513], '(121)': [1521], 'Thr-410': [1528], 'PDK1': [1530, 1930], '(25Le': [1531], 'Good': [1532], 'J.A.': [1533, 1969, 2005, 2258, 2327, 2360, 2779, 2801, 2977, 3026, 3063, 3197, 3286, 3876, 3912, 4617, 4654, 4677, 4694, 4714, 5662, 5791, 5862, 5868], 'Ziegler': [1534], 'W.H.': [1535], 'Parekh': [1536], 'D.B.': [1537], 'Allessi': [1538, 1639], 'D.R.': [1539, 1640, 1684, 3504], 'Cohen': [1540, 1641, 1900, 2192], '281:': [1546], '2042-2045Crossref': [1547], '(976)': [1550], 'Changes': [1553, 4758], 'cytosolic': [1555, 4844], 'Ca2+levels': [1556], 'occur': [1558], 'mechanisms': [1563, 2953], '(26Nairn': [1564, 3346, 4778, 4859], 'Palfrey': [1566, 3348, 4780, 4861], 'H.C.': [1567, 3349, 4781, 4862], '295-318Google': [1585, 3367, 4799, 4880], 'First,': [1587], 'operate': [1589, 4738], 'channels': [1591], 'allow': [1593], 'influx': [1594], 'from': [1595, 2183, 4804], 'space.': [1598], 'Second,': [1599], 'Ins(1,4,5)P3,': [1600], 'GPCR,': [1608], 'endoplasmic': [1614], 'reticulum': [1615, 4807], 'releases': [1617], 'into': [1619], 'cytosol.': [1621], 'regulates': [1624], 'cellular': [1626, 2514], 'processes': [1627, 5719], 'besides': [1628], 'synthase,': [1632], 'including': [1633, 3274, 5351], 'insulin-stimulated': [1634, 3598, 5508, 5563, 5586], '(27Cross': [1637], 'D.A.E.': [1638], 'Andjelkovich': [1643], '378:': [1649], '785-789Crossref': [1650], '(4397)': [1653], 'Phosphorylation': [1656, 1881, 2166, 2575, 2662, 3799], 'GSK-3': [1658, 1673, 3500, 4092, 4580], 'Ser-9': [1660], 'inactivates': [1661], 'correlated': [1666], 'phosphorylated': [1675, 2095, 2625, 2707, 2853, 3002, 3048, 3077, 3100, 3631, 5764], 'directly': [1676], 'vivo': [1680, 2711], '(28Hajduch': [1681, 3501], 'Alessi': [1683, 3503], 'Hundal': [1687, 3507], 'H.S.': [1688, 3508], 'Diabetes.': [1689, 3509], '47:': [1691, 3511], '1006-1013Crossref': [1692, 3512], '(296)': [1695, 3496, 3515], '29van': [1698], 'Weeren': [1699], 'P.C.': [1700], 'Bruyn': [1701], 'M.T.': [1702, 4186, 4251], 'de': [1703], 'Vries-Smits': [1704], 'M.M.': [1705], 'van': [1706], 'Lint': [1707], 'Burgering': [1709], 'B.M.': [1710], '13150-13156Abstract': [1716], '(313)': [1724], 'mTOR': [1727, 1818, 2187, 3796, 5228, 5434, 5583], '290-kDa': [1730], '(30Scott': [1738], 'Brunn': [1740], 'G.J.': [1741, 1768, 1796, 2213, 2926, 3639], 'Kohn': [1742], 'R.A.': [1743], 'Lawrence': [1744, 1825, 2224, 2912, 2933, 3646, 3671, 3713, 4140, 4345], 'J.C.': [1745, 1826, 2113, 2225, 2319, 2352, 2793, 2913, 2934, 3018, 3647, 3672, 3714, 4142, 4347], 'Proc.': [1746, 1906, 2198, 2560, 2830, 3741, 4897, 5067, 5399, 5869], 'Natl.': [1747, 1907, 2199, 2561, 2831, 3742, 4898, 5068, 5400, 5870], 'Acad.': [1748, 1908, 2200, 2562, 2832, 3743, 4899, 5069, 5401, 5871], '95:': [1754, 1914, 2206, 5877], '7772-7777Crossref': [1755], '(414)': [1758], 'Ser/Thr-Pro': [1763], 'motifs': [1764], '(31Abraham': [1765, 1793], 'R.T.': [1766, 1794, 2115, 2227, 4304], 'Wiederrecht': [1767, 1795], 'Annu.': [1769, 1797], 'Rev.': [1770, 1798], 'Immunol.': [1771, 1799, 5249, 5704], '14:': [1773, 1801], '483-510Crossref': [1774, 1802], '(575)': [1777, 1805], 'As': [1780], 'name': [1782], 'implies,': [1783], 'immunosuppressant': [1791], 'ability': [1809], 'cause': [1813, 4123, 4575], 'attenuated': [1820], 'cAMP': [1822], '(32Scott': [1823], '34496-34501Abstract': [1832], '(72)': [1840], 'major': [1844], 'responsible': [1846], 'p70S6K': [1854, 3147, 3930, 4331, 4498, 5469, 5474, 5484], '(33Proud': [1855, 3113], '21:': [1861, 3119], '181-185Abstract': [1862, 3120], '(199)': [1868, 3126], 'hierarchical': [1875], 'seven': [1878, 5735], 'occurs': [1885, 2169, 2663], 'first,': [1886], 'making': [1887], 'Thr-389': [1888], 'available': [1889], 'rapamycin-sensitive': [1894, 3684, 3963], 'pathway': [1895, 2303, 2313, 3415, 3687, 3782, 3805, 4131, 4239, 5430, 5624], '(34Burnett': [1896, 2188], 'P.E.': [1897, 2189], 'Barrow': [1898, 2190], 'R.K.': [1899, 2191], 'N.A.': [1901, 2193, 4997], 'Snyder': [1902, 2194], 'S.H.': [1903, 2195], 'Sabatini': [1904, 2196], 'D.M.': [1905, 2197], '1432-1437Crossref': [1915, 2207], '(947)': [1918, 2210], 'culminating': [1922], 'Thr-229': [1926], 'active': [1929, 2599, 3554, 5573], '(35Pullen': [1931], 'Dennis': [1933, 3160, 5438, 5489], 'P.B.': [1934, 3161, 5439, 5490], 'Andjelkovic': [1935], 'Dufner': [1937], 'Kozma': [1939, 2045, 5395], 'S.C.': [1940, 2046, 5396], 'Thomas': [1943, 2043, 3166, 3739, 4009, 5397, 5446, 5495], '707-710Crossref': [1948], '(731)': [1951], 'Multipotential': [1954], 'becomes': [1960], 'membrane-associated': [1961], '(36Chang': [1966, 3194, 3283, 3909], 'Y.W.': [1967, 3195, 3284, 3910], 'Traugh': [1968, 3062, 3196, 3285, 3875, 3911, 4676, 4693, 4713, 5790], '28252-28257Abstract': [1975, 3203, 3292, 3918], '(44)': [1983, 3211, 3300, 3926], 'p90S6K': [1986], 'forming': [1995], 'complexes': [1996], '-2': [2000, 2250, 2307, 2771], 'undergoing': [2002], '(37Smith': [2004], 'Poteet-Smith': [2006], 'C.E.': [2007], 'Malarkey': [2008], 'Sturgill': [2010], 'T.W.': [2011], '1999;': [2015, 2076, 2331, 2364, 2385, 2805, 2868, 3030, 3861, 4036, 4222, 4312, 4381, 4963, 5036, 5158, 5333], '274:': [2016, 2077, 4037, 4223, 4313, 4382, 5334], '2893-2898Abstract': [2017], '(244)': [2025], 'Additional': [2028], 'kinases': [2030, 2583], 'continue': [2031], '(38Shima': [2035], 'Pende': [2037], 'Chen': [2039], 'Y.': [2040, 2060, 2064, 3473, 4210, 4296, 4369], 'Fumagalli': [2041, 3158, 5487], '6649-6659Crossref': [2051], '39New': [2055], 'Li': [2059], 'Bassett': [2061], 'W.W.': [2062], 'Feng': [2063], 'Ludwig': [2065], 'Padova': [2067], 'F.D.': [2068], 'Gram': [2069], 'Han': [2071], '1026-1032Abstract': [2078], '(47)': [2086], 'PHAS-I': [2089, 3629, 4333, 4469, 4529], 'was': [2090, 2105], 'originally': [2091], 'observed': [2092], 'increased': [2098], 'upon': [2099], 'treatment': [2101, 3179], 'cells': [2103, 3004, 4056, 5051, 5126, 5521], 'later': [2106], 'eIF4E': [2110, 2845, 2879, 2951, 2960, 2999, 3009, 3801, 3834, 4405, 4445, 4607, 5123, 5644], 'specifically': [2111], '(40Lawrence': [2112], 'Abraham': [2114, 2226, 4303], '22:': [2120], '345-349Abstract': [2121], '(186)': [2127, 2745], 'Two': [2130, 2460], 'additional': [2131, 3550], 'since': [2134], 'been': [2135, 2469, 4559, 5746], 'found,': [2136], 'PHAS-II': [2137], 'PHAS-III': [2139], '(41Poulin': [2140], 'Gingras': [2142, 2375, 2858, 2927, 3640, 3733, 4472, 4503, 4533, 5442], 'A.C.': [2143, 4504, 4894, 5245, 5700], 'Olsen': [2144], 'Chevalier': [2146], '14002-14007Abstract': [2155], '(233)': [2163], 'PHAS': [2168, 2894, 2958, 3014, 4127, 5423], 'six': [2171], 'more': [2173, 3080, 5812], 'sites,': [2174], 'five': [2177, 3102], 'appear': [2180, 4070], 'Scholar,42Brunn': [2212], 'Hudson': [2214], 'C.C.': [2215], 'Sekulic': [2216], 'Williams': [2218], 'J.M.': [2219, 5083, 5864], 'Hosoi': [2220, 4301], 'Houghton': [2222, 4305], '99-101Crossref': [2231], '(814)': [2234], 'homologous': [2239], 'p90S6K,': [2241], 'were': [2242, 5763], 'identified': [2243, 5747], 'partners': [2246], '(43Waskiewicz': [2251, 2772, 4610], 'A.J.': [2252, 2317, 2350, 2684, 2773, 2791, 2969, 3016, 3523, 4611, 4646, 4892], 'Flynn': [2253, 2774, 2966, 4612, 4643], 'Cooper': [2257, 2326, 2359, 2778, 2800, 2976, 3025, 4616, 4653], '16:': [2262, 2283, 2783, 3171, 3434, 3455, 3700, 4549, 4621, 4634, 5185, 5500, 5539], '1909-1920Crossref': [2263, 2784, 4622], '(793)': [2266, 2787, 4625], 'screen': [2272], '(44Fukunaga': [2276], 'Hunter': [2278, 2379, 2862, 4629], '1921-1933Crossref': [2284, 4635], '(559)': [2287, 4638], 'Mnk': [2290], 'Thr-197': [2296], 'Thr-202': [2298], 'stress-activated': [2312], 'p38': [2315], '(45Waskiewicz': [2316, 2349, 3015], 'Johnson': [2318, 2351, 2792, 3017], 'Penn': [2320, 2353, 2794, 3019], 'Mahalingam': [2322, 2355, 2796, 3021], 'Kimball': [2324, 2357, 2798, 3023, 3852], 'S.R.': [2325, 2358, 2799, 3024, 3732, 3853, 4098, 4407], '1871-1880Crossref': [2333, 2366, 2807, 3032], '(404)': [2336, 2369, 2810, 3035], 'Interestingly,': [2339], 'Mnk1': [2340, 2769, 2963, 4609], 'COOH': [2345], 'terminus': [2346], 'eIF4G': [2348, 2850, 3837, 3867, 4673], 'Scholar,46Pyronnet': [2371], 'Imataka': [2373, 2856], 'A.-C.': [2376, 2859, 3734, 3760, 4473, 4534], 'Fukunaga': [2377, 2860], '18:': [2386, 2869, 3492], '270-279Crossref': [2387, 2870], '(537)': [2390, 2873], 'Ca2+/CaM': [2398], 'putative': [2402], 'CaM-binding': [2403], '(47Redpath': [2410], 'N.T.': [2411, 2413, 2445, 2641, 2688, 3370, 3372, 3527, 3966, 4586, 5376], 'Price': [2412, 2640, 2687, 3371, 3526, 4585], '271:': [2420, 2650, 4595], '17547-17554Abstract': [2421], '(66)': [2429], 'cAMP,': [2438], 'independently': [2439], '(48Diggle': [2442], 'T.A.': [2443], 'Redpath': [2444], 'Heesom': [2446], 'K.J.': [2447], '336:': [2453], '525-529Crossref': [2454], '(52)': [2457], 'types': [2461], 'signal-induced': [2463], 'modifications': [2464, 4062], 'translation': [2466, 3149, 4916, 4934, 5129, 5300, 5828], 'described': [2470], 'date:': [2472], 'changing': [2473], 'intrinsic': [2475], 'properties': [2479, 5011], 'sequestration': [2486], 'inactive': [2492, 2887], 'formation': [2495, 2585, 2884], 'dissociation': [2497, 2896], 'controlled': [2502], 'phosphorylation.': [2504], 'situations': [2506], 'eIF2α': [2512, 2517, 2577, 3403, 4084, 4817], 'represent': [2513], 'stress,': [2515], 'changes': [2520], 'normal': [2525], 'pathways,': [2527], 'e.g.': [2528, 3990], 'those': [2529], 'regulated': [2530, 2882, 5314], '(49Hinnebusch': [2534], '21661-21664Abstract': [2541], '(434)': [2549], 'interleukin-3': [2553], '(50Ito': [2554], 'Jagus': [2556], 'May': [2558], 'W.S.': [2559], '91:': [2568, 2838, 5407], '7455-7459Crossref': [2569], '(78)': [2572], 'Ser-51': [2579], 'stable': [2588], 'eIF2B': [2591, 2600, 3409, 3548, 4077, 4402, 4578, 5630], '(Fig.': [2592], '1),': [2593], 'reducing': [2595], 'concentration': [2597], '(51Clemens': [2601], 'M.J.': [2602, 4508], '139-172Google': [2620], 'ε': [2628], 'inactivated': [2631], 'GSK-3α': [2633], '-β': [2635], '(52Welsh': [2636, 4581], 'Miyamoto': [2638, 4583], 'Safer': [2642, 4587], '11410-11413Abstract': [2651, 4596], '(88)': [2659, 4604, 5005], 'Ser-540,': [2665], 'although': [2666], 'evidence': [2667], 'suggests': [2668, 5612], 'priming': [2671], 'Ser-544': [2674], 'some': [2676, 4066, 5619, 5821], '(53Welsh': [2681, 3520], 'Loughlin': [2683, 3522], 'Soc.': [2692, 3531], 'Trans.': [2693, 3532], '25': [2695, 3534], '(suppl.):': [2696, 3535], '191Crossref': [2697, 3536], '(7)': [2699, 3538], 'cap-binding': [2704], 'Ser-209': [2709], '(54Joshi': [2712], 'Cai': [2714], 'A.-L.': [2715], 'Keiper': [2716], 'B.D.': [2717], 'Minich': [2718], 'W.B.': [2719, 2823], 'Mendez': [2720, 3603], 'Beach': [2722], 'C.M.': [2723, 4166, 4277], 'Stepinski': [2724], 'Stolarski': [2726], 'Darzynkiewicz': [2728], '14597-14603Abstract': [2737], '55Flynn': [2748], '21684-21688Abstract': [2757], '(138)': [2765, 3626, 4116, 4425], '45Waskiewicz': [2790], 'affinity': [2819], 'caps': [2821], '(56Minich': [2822], 'Balasta': [2824], 'Goss': [2826], 'D.J.': [2827], '7668-7672Crossref': [2839], '(261)': [2842], 'variants': [2846], 'unable': [2847], 'poorly': [2852, 5047], '(46Pyronnet': [2854], 'availability': [2877], 'PHAS,': [2890, 3006, 5297], '(57Lin': [2900], 'Kong': [2902, 3661], 'X.': [2903, 2965, 3662, 4162, 4273, 4642], 'Haystead': [2904, 3663], 'T.A.J.': [2905, 3664], 'Pause': [2906, 3665], 'Belsham': [2908, 2925, 3638, 3667], '266:': [2916, 3068, 3675, 3881, 4719, 5096], '653-656Crossref': [2917, 3676], '(602)': [2920, 3679], '58Pause': [2923], 'Donze': [2929, 3642], 'O.': [2930, 3643, 5329], 'Lin': [2931, 3644, 4138, 4343], '371:': [2939, 3652], '762-767Crossref': [2940, 3653], '(1063)': [2943, 3656], 'relationship': [2947], 'between': [2948, 3144, 3223, 5420], 'unclear.': [2955, 3139], 'vitro,': [2957], 'inhibits': [2959, 4812, 4851], '(59Wang': [2964], 'Waskiewicz': [2968, 4645], 'Webb': [2970, 4647], 'B.L.J.': [2971, 4648], 'Vries': [2972, 4649], 'R.G.': [2973, 4650], 'Baines': [2974, 4651], 'I.A.': [2975, 4652], '9373-9377Abstract': [2985, 4662], '(256)': [2993, 4670], 'vivo,': [2998], 'extensively': [3001], 'overexpressing': [3005], 'suggesting': [3007, 3567], 'independent': [3012], 'linking': [3039], 'protein,': [3040], 'part': [3042], 'eIF4F': [3045], 'unknown': [3050], 'multipotential': [3053, 3185, 3278, 3906], '(60Morley': [3056, 3869], 'S.J.': [3057, 3870, 4032, 4675, 4692, 5789], 'Dever': [3058, 3871], 'T.E.': [3059, 3872], 'Etchison': [3060, 3873], '1991;': [3067, 3880, 4718, 5095], '4669-4672Abstract': [3069, 3882], 'stimulatory': [3081], 'vitroprotein': [3084], 'Ser': [3103], 'residues,': [3104], 'located': [3105], '235,': [3107], '236,': [3108], '240,': [3109], '244,': [3110], '247': [3112], 'However,': [3129, 3544, 4556, 5462], 'effect': [3131], 'correlation': [3143], 'mRNAs': [3151, 4919, 4980, 5008, 5045, 5134, 5303, 5310, 5360, 5655, 5837], 'containing': [3152], '5′-TOP': [3154, 5309, 5359, 5476], '(61Jefferies': [3156, 5485], 'B.J.': [3157, 5486], 'Reinhard': [3162, 5393, 5491], 'Pearson': [3164, 5493], 'R.B.': [3165, 5494], '3693-3704Crossref': [3172, 5501], '(813)': [3175, 5504], 'ribosomes': [3183, 5056, 5660], 'increases': [3188, 3412], 'rate': [3190, 5826], '2-fold': [3193], 'study': [3216], 'implicates': [3217], 'interaction': [3222], '(62Chiaberge': [3229], 'Cassarino': [3231], 'Mangiarotti': [3233], '27070-27075Abstract': [3240], '(10)': [3248], 'α,': [3260], 'γ,': [3262], 'δ': [3264], 'subunits.': [3265], 'Various': [3266], 'phosphorylatedin': [3269], 'vitro': [3270], 'casein': [3275], 'II,': [3277], 'kinase,': [3280], 'latter': [3305, 3338, 3902], 'cases,': [3307], 'phosphorylations': [3309], 'stimulation': [3313, 3829, 4883], 'GDP/GTP': [3317], 'exchange,': [3318], 'respectively.': [3319], 'Thr-56': [3331], 'Thr-58,': [3333], 'site': [3339], 'requiring': [3340, 5724], 'prior': [3341], '63Redpath': [3369], 'Severinov': [3373], 'K.V.': [3374], 'Eur.': [3377], '1993;': [3380], '213:': [3381], '689-699Crossref': [3382], '(157)': [3385], 'Insulin,': [3388], 'far': [3390], 'characterized': [3393], 'effector': [3394], 'synthesis,': [3397, 5636], 'elongation.': [3402], 'does': [3405, 4240, 4291, 5417], 'not': [3406, 3571, 4095, 4241, 4404, 4737, 4914, 5418, 5558, 5591], 'change,': [3407], 'nonetheless': [3411], '(Tyr-608,': [3417, 3785], '-628,': [3418, 3786], '-658;': [3420], '64Mendez': [3422], 'Myers': [3424, 3445, 3690, 5175, 5529], 'M.G.': [3425, 3446, 3602, 3691, 3932, 5176, 5530], '2857-2864Crossref': [3435, 3456, 3701, 5186, 5540], '(208)': [3438, 3459, 3704, 4158, 4363, 5189, 5543], '→': [3441, 3462, 3464, 3499, 3518, 3789, 3791, 3793, 3795, 3797, 3808, 3810, 3812, 3814, 3816, 3818], '(64Mendez': [3443, 3688, 5173, 5527], '(65Kitamura': [3466], 'Ogawa': [3468], 'W.': [3469, 5085, 5664], 'Sakaue': [3470], 'Hino': [3472], 'Kuroda': [3474], 'Takata': [3476], 'Matsumoto': [3478], 'Maeda': [3480], 'Konishi': [3482], 'Kikkawa': [3484], 'Masuga': [3486], '3708-3717Crossref': [3493], 'eIF2Bε': [3519], '(see': [3541, 5459], 'activate': [3547, 4401, 5286], 'routes,': [3551], 'because': [3552, 5428], 'general': [3557, 5511, 5587, 5626], 'insulin-dependent': [3562], 'manner': [3563], 'without': [3564], 'p70S6K,': [3566, 5427], '(23Mendez': [3573, 4741, 5594], 'Binding': [3590], 'IRS-1(Tyr-1172': [3594], '-1222)': [3596], 'attenuates': [3597], '(66Myers': [3601], 'Shi': [3605], 'Pierce': [3607, 3939], 'J.H.': [3608, 3940], 'M.W.': [3612], '26908-26914Abstract': [3618], '(58Pause': [3636], '57Lin': [3659], 'MAPK-insensitive': [3686], '67Azpiazu': [3707], 'Saltiel': [3709], 'A.R.': [3710], 'DePaoli-Roach': [3711], 'A.A.': [3712], '27:': [3719], '5033-5039Abstract': [3720], '(156)': [3727], '68von': [3730], 'Manteuffel': [3731, 5436], 'Ming': [3735], 'X.-F.': [3736], '93:': [3749], '4076-4080Crossref': [3750], '(223)': [3753], 'includes': [3757], '(69Gingras': [3759], 'Kennedy': [3761], 'S.G.': [3762], "O'Leary": [3763], 'M.A.': [3764, 4823], 'Hay': [3767], 'Genes': [3769], 'Dev.': [3770], '12:': [3772, 5674], '502-513Crossref': [3773], '(730)': [3776], 'indicating': [3779, 5479], '-658)': [3788], 'PHAS.': [3798], '(Tyr-895)': [3807], 'Raf': [3813], 'MEK': [3815], 'ERK': [3817], 'Mnk.': [3819], '(There': [3820], 'contribute': [3826], 'MAPK,': [3831], 'especially': [3832, 5884], 'Shc.)': [3833], 'association': [3835], '(70Sinaud': [3842], 'Balage': [3844], 'Bayle': [3846], 'Dardevet': [3848], 'Vary': [3850], 'T.C.': [3851, 3934], 'Jefferson': [3854, 4101, 4410], 'Grizard': [3856], 'Am.': [3858], 'Physiol.': [3860], '39:': [3862], 'E50-E61Google': [3863], 'mechanisms:': [3895], 'eEF1': [3898, 4708], 'S6,': [3900, 5741], 'occurring': [3903], '(71Myers': [3931], 'Grammer': [3933], 'Wang': [3935], 'Sun': [3937], 'X.J.': [3938], 'Blenis': [3941], '28783-28789Abstract': [3950], 'dephosphorylation': [3958, 4082], 'route': [3964], '(72Redpath': [3965, 5375], '2291-2297Crossref': [3975, 5385], '(231)': [3978, 5388], 'Other': [3981], 'acting': [3984], 'produce': [3987], 'similar': [3988], 'changes,': [3989], 'factor,': [3993, 3996], 'nerve': [3994], '(73Kleijn': [3999], 'Scheper': [4003], 'G.C.': [4004], 'A.A.M.': [4010], '5536-5541Abstract': [4016], '(55)': [4024], '74Fraser': [4027], 'C.S.': [4028], 'Pain': [4029], 'Morley': [4031], '196-204Abstract': [4038], '(53)': [4046], 'Addition': [4049], 'starved': [4054], 'many': [4058, 5348], 'same': [4061], 'insulin,': [4064, 4120, 4236, 4398, 4733], 'different.': [4073], 'increased,': [4079], 'partly': [4080, 4086], 'eIF2Bε,': [4090, 5738], 'altered': [4096], '(75Kimball': [4097, 4406], 'Horetsky': [4099, 4408], 'R.L.': [4100, 4409], '30945-30953Abstract': [4108, 4417], 'Like': [4119], 'p70S6Kand': [4126], 'mTOR-dependent': [4130], '(76Xu': [4132, 4337], 'Kwon': [4134, 4339], 'Marshall': [4136, 4341], 'C.A.': [4137, 4342], 'T.-A.': [4139, 4344], 'Jr.,': [4141, 4346], 'McDaniel': [4143, 4348], '28178-28184Abstract': [4150, 4355], '77Wang': [4161, 4272], 'Campbell': [4163, 4274], 'L.E.': [4164, 4275], 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'do': [4736, 4913], 'level': [4761], 'distribution': [4767], 'among': [4768], 'compartments': [4769], 'affect': [4770], 'ways': [4777], 'Depletion': [4801], 'sarcoplasmic/endoplasmic': [4806], 'hormones': [4809], 'like': [4810, 5171], 'vasopressin': [4811], 'PKR': [4819], '(87Reilly': [4820], 'Brostrom': [4822, 4824], 'C.O.': [4825], '3747-3755Abstract': [4831], '(38)': [4839], 'Elevation': [4842], 'agents': [4847], 'bradykinin': [4850], 'eEF2K': [4858], 'Similarly,': [4882, 5647], 'NMDA': [4886], '(88Scheetz': [4891], 'Nairn': [4893, 5244, 5699], 'Constantine-Paton': [4895], '94:': [4905], '14771-14775Crossref': [4906], '(58)': [4908], 'Signaling': [4911], 'stimulate': [4915, 5299], 'all': [4918, 4971], 'equally.': [4920], 'Messenger': [4921], 'RNAs': [4922], 'widely': [4924], 'efficiency.': [4927], 'Factors': [4928], 'contributing': [4929], 'low': [4931], 'efficiency': [4932], 'highly': [4937], 'structured': [4938], '5′-UTR,': [4939], 'upstream': [4943], 'AUGs,': [4944], 'poor': 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'expression': [5464, 5570], 'dominant': [5467], 'interfering': [5468], 'blocks': [5470], 'translation,': [5478], 'role': [5482], '32D': [5520], 'dissected': [5524], 'Insulin-stimulated': [5546], 'total': [5547], 'only': [5552, 5734], '∼10%,': [5553], 'actin': [5555], 'affected': [5559], 'all,': [5561], 'completely': [5567], 'inhibited.': [5568, 5895], 'Also,': [5569], 'absence': [5577], 'bypasses': [5581], 'pathway,': [5584], 'permits': [5585], 'point': [5620], 'one': [5623, 5632, 5713], 'stimulating': [5625, 5633], 'accounting': [5637], '∼10%': [5639], 'total,': [5642], 'S6.': [5646], 'T-cell': [5648], '13%': [5651], 'pre-existing': [5654], '(100Garcia-Sanz': [5661], 'Mikulits': [5663], 'Livingstone': [5665], 'Lefkovits': [5667], 'Mullner': [5669], 'FASEB': [5671], '299-306Crossref': [5675], '(49)': [5678], '15%': [5685], 'decrease': [5686], 'Protein': [5710], 'most': [5716], 'complicated': [5717], 'biochemical': [5718], 'undertaken': [5720], 'cell,': [5723], 'roughly': [5725], '150': 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