The Circadian Clock Component BMAL1 Is a Critical Regulator of p21 Expression and Hepatocyte Proliferation

Name: Work Video:
Duration: 3 min 30 s
Aline Gréchez‐Cassiau; Béatrice Rayet; Fabienne Guillaumond; Michèle Teboul; Franck Delaunay
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4532, 4534, 4620, 4622, 4683, 4705, 4746], 'Hogenesch': [462, 613, 1942, 2557, 2794, 2826, 4696], 'J.B.': [463, 614, 1943, 2558, 2795, 2827, 4697], 'Kay': [464, 611], 'S.A.': [465, 612], 'Nature.': [466, 479], '2002;': [467, 480, 582, 824, 885, 1025, 2650, 3055, 3580, 3746, 4355, 4880, 4958], '417:': [468], '329-335Crossref': [469], 'PubMed': [470, 483, 498, 515, 590, 624, 666, 736, 791, 809, 827, 842, 874, 888, 912, 957, 979, 1009, 1033, 1056, 1081, 1206, 1221, 1234, 1757, 1959, 2540, 2574, 2658, 2811, 2835, 2936, 2968, 3063, 3090, 3169, 3274, 3306, 3367, 3419, 3588, 3615, 3754, 4159, 4358, 4401, 4545, 4633, 4710, 4767, 4888, 4903, 4931, 4961], 'Scopus': [471, 484, 499, 516, 591, 625, 667, 737, 792, 810, 828, 843, 875, 889, 913, 958, 980, 1010, 1034, 1057, 1082, 1207, 1222, 1235, 1960, 2541, 2575, 2659, 2812, 2836, 2937, 2969, 3064, 3091, 3170, 3275, 3307, 3368, 3420, 3589, 3616, 3755, 4160, 4402, 4546, 4634, 4711, 4768, 4889, 4904, 4932, 4962], '(775)': [472], 'Google': [473, 486, 501, 518, 593, 627, 669, 739, 794, 812, 830, 845, 877, 891, 915, 960, 982, 1012, 1036, 1059, 1084, 1185, 1209, 1224, 1237, 1758, 1962, 2543, 2577, 2661, 2814, 2838, 2939, 2971, 3066, 3093, 3172, 3277, 3309, 3370, 3422, 3591, 3618, 3757, 4162, 4359, 4404, 4548, 4636, 4713, 4770, 4891, 4906, 4934, 4964], 'Scholar,': [474, 487, 502, 594, 795, 813, 831, 846, 878, 892, 961, 983, 1013, 1037, 1186, 1210, 1225, 2544, 2783, 2815, 2940, 3067, 3278, 3592, 4892, 4907, 4935], '2Reppert': [475], 'S.M.': [476, 1321, 2769, 2789], 'Weaver': [477], 'D.R.': [478], '418:': [481], '935-941Crossref': [482], '(3416)': [485], '3Ko': [488], 'C.H.': [489], 'Takahashi': [490, 505, 2798, 3603, 4698], 'J.S.': [491, 506, 2799, 3604, 4699], 'Hum.': [492, 510], 'Mol.': [493, 3080, 3296, 3361, 3610, 4757], 'Genet.': [494, 511, 1330, 2649, 2778, 4155], '2006;': [495, 3082, 4759], '15:': [496, 3365], 'R271-R277Crossref': [497], '(1239)': [500], '4Lowrey': [503], 'P.L.': [504], 'Annu.': [507], 'Rev.': [508, 4898], 'Genomics.': [509], '2004;': [512, 616, 663, 1951, 2566, 2832, 3411, 3612, 4928], '5:': [513], '407-441Crossref': [514], '(769)': [517], 'Scholar).': [519, 628, 670, 916, 1060, 1238, 1335, 1759, 1963, 2578, 2662, 2839, 3094, 3310, 3371, 3423, 3619, 4360, 4405, 4637, 4714, 4771, 4965], 'mechanism': [521, 651, 930, 1244, 3493], 'involves': [522], 'complex': [523, 3656], 'interlocked': [524], 'positive': [525, 4166, 4261], 'negative': [527, 3541, 3720, 4263], 'transcriptional/posttranslational': [528], 'feedback': [529], 'loops': [530], 'Clock,': [535], 'Bmal1,': [536], 'Per1,': [537], 'Per2,': [538], 'Cry1,': [539], 'Cry2': [541], 'their': [543, 3217, 4053], 'products.': [545], 'The': [546, 1649, 1668, 1760, 1850, 1901, 2115, 2271, 3228, 3901, 4024, 4173, 4587], 'robustness': [547], 'ensured': [552], 'additional': [554, 3137, 3922, 4259, 4272], 'regulators': [555, 921, 3542, 4264], 'such': [556, 755], 'as': [557, 756, 771, 773, 1115, 2399, 2683, 2864, 3537, 3630, 3730, 4511, 4603, 4794, 4796, 4849], 'REV-ERBα': [559, 3844, 3898, 3978, 4170, 4302], '(NR1D1)': [560], 'RORα': [562], '(NR1F1)': [563], '(5Preitner': [567, 3565], 'N.': [568, 900, 3071, 3566, 4748], 'Damiola': [569, 3567], 'F.': [570, 906, 950, 987, 1074, 1189, 1947, 2518, 2562, 2645, 3162, 3260, 3407, 3568, 3606, 4538, 4626, 4911, 4953], 'Lopez-Molina': [571, 3569], 'L.': [572, 659, 1015, 1041, 1197, 1742, 3045, 3073, 3570, 3736, 4750, 4870, 4894, 4925], 'Zakany': [573, 3571], 'J.': [574, 660, 786, 864, 908, 969, 998, 1019, 1039, 1195, 1329, 1948, 2529, 2563, 2777, 2926, 3049, 3256, 3354, 3572, 3609, 3740, 4396, 4687, 4874, 4954], 'Duboule': [575, 3573], 'D.': [576, 2954, 3077, 3574, 4388, 4390, 4754], 'Albrecht': [577, 3575], 'U.': [578, 580, 1050, 3409, 3576, 3578, 4704], 'Schibler': [579, 3408, 3577], 'Cell.': [581, 1024, 2802, 2961, 3054, 3081, 3265, 3297, 3410, 3579, 3745, 4758, 4879], '110:': [583, 3581], '251-260Abstract': [584, 3582], 'Full': [585, 587, 619, 621, 869, 871, 974, 976, 1004, 1006, 1028, 1030, 1954, 1956, 2535, 2537, 2569, 2571, 2653, 2655, 2806, 2808, 2931, 2933, 2965, 3058, 3060, 3085, 3087, 3269, 3271, 3301, 3303, 3414, 3416, 3583, 3585, 3749, 3751, 4762, 4764, 4883, 4885], 'Text': [586, 588, 620, 622, 870, 872, 975, 977, 1005, 1007, 1029, 1031, 1955, 1957, 2536, 2538, 2570, 2572, 2654, 2656, 2807, 2809, 2932, 2934, 2966, 3059, 3061, 3086, 3088, 3270, 3272, 3302, 3304, 3415, 3417, 3584, 3586, 3750, 3752, 4763, 4765, 4884, 4886], 'PDF': [589, 623, 873, 978, 1008, 1032, 1958, 2539, 2573, 2657, 2810, 2935, 2967, 3062, 3089, 3273, 3305, 3418, 3587, 3753, 4766, 4887], '(1695)': [592, 3590], '6Sato': [595], 'T.K.': [596], 'Panda': [597, 1932, 2547, 2824, 4682], 'Miraglia': [599], 'L.J.': [600], 'Reyes': [601], 'T.M.': [602], 'Rudic': [603], 'R.D.': [604, 2817], 'McNamara': [605, 2818], 'P.': [606, 904, 997, 1021, 1045, 2528, 2819, 3051, 3742, 4876], 'Naik': [607], 'K.A.': [608, 4695], 'FitzGerald': [609], 'G.A.': [610, 848, 880, 963, 2829, 2920], 'Neuron.': [615], '43:': [617], '527-537Abstract': [618], '(803)': [626], 'Furthermore,': [629], 'extensive': [630], 'multilevel': [631], 'posttranslational': [632], 'regulation': [633, 937, 1280, 3721, 3919], 'various': [635], 'components': [637, 3527], 'shown': [641, 744, 2631, 3731, 4720], 'to': [642, 699, 925, 1152, 1249, 1340, 1383, 1443, 1448, 1644, 2010, 2035, 2042, 2110, 2238, 2307, 2337, 2388, 2448, 2680, 2714, 2723, 2849, 2912, 3031, 3038, 3318, 3377, 3381, 3474, 3624, 3773, 3795, 3969, 4017, 4253, 4522, 4671, 4815, 4830, 4865, 4969, 4980, 4992], 'play': [643, 4254, 4270], 'an': [644, 724, 1171, 2602, 2724, 3214, 3700, 4107, 4271, 4732, 4817], 'important': [645, 1172, 4733], 'role': [646, 1173, 4109], '(7Harms': [652], 'E.': [653, 902, 1193, 3399, 4909, 4937], 'Kivimae': [654], 'Young': [656], 'M.W.': [657, 4915], 'Saez': [658], 'Biol.': [661, 999, 1949, 2530, 2564, 2831, 3363], 'Rhythms.': [662], '19:': [664, 825, 886, 910], '361-373Crossref': [665], '(144)': [668], 'There': [671], 'substantial': [673], 'evidences': [674, 4855], 'through': [677, 1100, 1150, 2491, 3106, 4643, 4651], 'occurs': [681], 'at': [682, 1303, 1395, 1529, 1562, 2056, 2069, 2074, 2079, 2085, 2261, 2277, 2610, 2854, 3177, 4096, 4117, 4194, 4784], 'times': [684], 'day/night': [687], 'cycle,': [688, 4327, 4600], 'suggesting': [689], 'function': [692, 2720], 'system': [697, 1260, 2759, 4862], 'this': [701, 936, 2873, 3927, 4239, 4454, 4473, 4662], 'fundamental': [702], 'process.': [703, 2729], 'Notably,': [704, 4112], 'after': [705, 1166], 'initial': [707], 'observation': [708, 2874], 'almost': [709], '40': [710], 'ago': [712], 'division': [715, 4599, 4824], 'unicellular': [718], 'algae': [719], 'Euglena': [720], '(8Edmunds': [727], 'Jr.,': [728], 'L.N.': [729], 'Funch': [730], 'R.R.': [731], 'Science.': [732, 953, 1077, 1202, 3165, 4541, 4629], '1969;': [733], '165:': [734], '500-503Crossref': [735], '(34)': [738], 'Scholar),': [740, 2972, 3758, 4163, 4549], 'numerous': [741], 'studies': [742], 'variation': [747], 'proliferative': [750, 4333], 'activity': [751, 1137, 1728, 1994, 2300, 3789, 3893, 4249, 4556], 'epithelia': [758], 'tongue,': [760], 'skin,': [761], 'oral': [762, 2917], 'mucosa,': [763], 'intestine,': [764], 'esophagus,': [765], 'stomach,': [766], 'duodenum,': [767], 'jejunum,': [768], 'rectum': [770], 'well': [772, 2510, 2902, 3335, 4795], 'bone': [775], 'marrow': [776], 'pancreas': [778], '(9Scheving': [779], 'L.E.': [780, 797], 'Burns': [781, 798], 'E.R.': [782, 799], 'Pauly': [783, 800], 'J.E.': [784, 801], 'Am.': [785, 863, 968, 2925, 4395], 'Anat.': [787, 804], '1972;': [788], '135:': [789], '311-317Crossref': [790], '(52)': [793], '10Scheving': [796], 'Tsai': [802], 'T.H.': [803], 'Rec.': [805], '1978;': [806], '191:': [807], '479-486Crossref': [808], '(128)': [811, 3617], '11Smaaland': [814], 'R.': [815, 882, 898, 1317, 1945, 2560, 2765, 2950, 3293, 3602], 'Sothern': [816, 857, 966, 2923], 'R.B.': [817, 858, 967, 2924], 'Laerum': [818], 'O.D.': [819], 'Abrahamsen': [820], 'J.F.': [821], 'Chronobiol.': [822, 883], 'Int.': [823, 884], '101-127Crossref': [826], '(100)': [829], '12Biederbick': [832], 'A.': [833, 948, 989, 1052, 1072, 1294, 1746, 1931, 2520, 2546, 3075, 3160, 3289, 3295, 4536, 4624, 4706, 4752, 4919], 'Elsasser': [834], 'H.': [835, 952, 1017, 1076, 3047, 3164, 3282, 3738, 4540, 4628, 4872], 'Cell': [836, 1216, 1409, 3362], 'Tissue': [837], 'Res.': [838, 1217, 1753, 4927], '1998;': [839, 1203], '291:': [840], '277-283Crossref': [841], '(13)': [844], '13Bjarnason': [847], 'Jordan': [849, 881, 964, 2921], 'R.C.': [850, 965, 2823, 2922, 3358], 'Wood': [851], 'P.A.': [852, 1319, 2767], 'Li': [853, 4940], 'Q.': [854], 'Lincoln': [855], 'D.W.': [856], 'Hrushesky': [859], 'W.J.': [860], 'Ben-David': [861], 'Y.': [862, 1229, 4149], 'Pathol.': [865, 970, 2927], '2001;': [866, 1001, 2532], '158:': [867], '1793-1801Abstract': [868], '(319)': [876], '14Bjarnason': [879], '129-140Crossref': [887], '(75)': [890], '15Granda': [893], 'T.G.': [894, 4943], 'Liu': [895, 1018, 3048, 3739, 4873, 4946], 'X.H.': [896, 1227], 'Smaaland': [897], 'Cermakian': [899], 'Filipski': [901], 'Sassone-Corsi': [903, 1044], 'Levi': [905, 4952], 'FASEB.': [907], '2005;': [909, 1053, 1231, 1332, 2780, 3298, 4156], '304-306Crossref': [911], '(132)': [914], 'several': [918, 2503], 'rhythmically,': [928], 'relevance': [934], 'remain': [938], 'understood': [940], '(16Matsuo': [941, 1065, 3153, 4529, 4617], 'T.': [942, 995, 1066, 2526, 2944, 3154, 3280, 3405, 3598, 4530, 4618], 'Yamaguchi': [943, 1067, 3155, 4531, 4619], 'Mitsui': [945, 1069, 3157, 4533, 4621], 'Emi': [947, 1071, 3159, 4535, 4623], 'Shimoda': [949, 1073, 3161, 4537, 4625], 'Okamura': [951, 1075, 3163, 4539, 4627], '2003;': [954, 1078, 3166, 3266, 4398, 4542, 4630, 4900], '302:': [955, 1079, 3167, 4543, 4631], '255-259Crossref': [956, 1080, 3168, 4544, 4632], '(917)': [959, 1083, 3171, 4547, 4635], '17Bjarnason': [962], '1999;': [971, 1218, 2928], '154:': [972, 2929], '613-622Abstract': [973, 2930], '(145)': [981, 2938], '18Grundschober': [984], 'C.': [985, 1023, 1293, 2516, 2791, 3053, 3401, 3403, 3744, 4394, 4878, 4921], 'Delaunay': [986, 1946, 2517, 2561, 3605, 4910], 'Puhlhofer': [988, 2519], 'Triqueneaux': [990, 2521], 'G.': [991, 1191, 2522, 3262, 3594, 4392], 'Laudet': [992, 1940, 2523, 2555, 2646, 3607], 'V.': [993, 1748, 1941, 2524, 2556, 2647, 3258, 3286, 3356, 3608], 'Bartfai': [994, 2525], 'Nef': [996, 2527], 'Chem.': [1000, 1950, 2531, 2565], '276:': [1002, 2533], '46751-46758Abstract': [1003, 2534], '(112)': [1011, 2542], '19Fu': [1014], 'Pelicano': [1016, 3046, 3737, 4871], 'Huang': [1020, 3050, 3741, 4875], 'Lee': [1022, 3052, 3743, 4877, 4895], '111:': [1026, 3056, 3747, 4881], '41-50Abstract': [1027, 3057, 3748, 4882], '(1042)': [1035, 3065, 3756, 4890], '20Hirayama': [1038], 'Cardone': [1040], 'Doi': [1042], 'M.': [1043, 1744, 1937, 2552, 3264, 4145, 4147, 4151], 'Proc.': [1046, 4700], 'Natl.': [1047, 4701, 4955], 'Acad.': [1048, 4702], 'Sci.': [1049, 4703], '102:': [1054], '10194-10199Crossref': [1055], '(86)': [1058], 'However,': [1061, 3712], 'Matsuo': [1062, 4526], 'et': [1063, 4527], 'al.': [1064, 4528], 'Scholar)': [1085, 3173], 'recently': [1087, 4132, 4719], 'demonstrated': [1088], 'gated': [1092], 'regenerating': [1098], 'Wee1': [1104, 3143, 3475], 'kinase,': [1105], 'regulator': [1107, 2904, 2999, 4592], 'G2/M': [1110, 3151, 4595, 4792], 'transition.': [1111], 'p21Waf1/CIP1': [1112], '(hereafter': [1113], 'referred': [1114, 1382], 'p21)': [1116], 'member': [1119], 'Cip/Kip': [1122], 'family': [1123], 'cyclin-dependent': [1125, 4657], 'kinase': [1126, 4588, 4658, 4730], 'inhibitors,': [1127], 'negatively': [1129], 'regulates': [1130, 4381], 'inhibiting': [1135], 'cyclin': [1139], 'E-cdk2': [1140], 'complexes': [1141], 'blocking': [1147, 2246, 2269], 'DNA': [1148, 1167, 1606, 2047, 2369, 2477, 3627, 4736, 4743, 4798], 'replication': [1149], 'binding': [1151], 'proliferating': [1153], 'antigen.': [1156], 'p21': [1157, 1250, 1264, 1598, 1650, 1695, 1699, 2283, 2401, 2409, 2482, 2583, 2597, 2668, 2734, 2844, 2879, 2889, 2906, 3035, 3105, 3229, 3313, 3328, 3347, 3388, 3428, 3438, 3465, 3510, 3522, 3552, 3687, 3694, 3724, 3770, 3854, 3917, 4008, 4215, 4266, 4286, 4363, 4408, 4439, 4460, 4464, 4491, 4500], 'major': [1161], 'p53': [1164, 2992, 3007, 3043], 'activated': [1165, 3867], 'damage': [1168, 4799], 'plays': [1170], 'epidermis': [1175], 'differentiation': [1176, 1449, 3343, 4319], '(21Dotto': [1177], 'G.P.': [1178, 1201, 4386], 'Biochim.': [1179], 'Biophys.': [1180], 'Acta.': [1181], '2000;': [1182, 2803], '1471:': [1183], 'M43-M56PubMed': [1184], '22Di': [1187], 'Cunto': [1188], 'Topley': [1190], 'Calautti': [1192], 'Hsiao': [1194], 'Ong': [1196], 'Seth': [1198], 'P.K.': [1199], 'Dotto': [1200], '280:': [1204], '1069-1072Crossref': [1205], '(254)': [1208], '23Gartel': [1211], 'A.L.': [1212, 1214], 'Tyner': [1213], 'Exp.': [1215], '246:': [1219], '280-289Crossref': [1220], '(580)': [1223], '24Pei': [1226], 'Xiong': [1228], 'Oncogene.': [1230], '24:': [1232, 1755], '2787-2795Crossref': [1233], '(138)': [1236], 'investigate': [1241], 'links': [1246], 'disruption': [1255, 4858], 'results': [1261, 3458, 3882, 4221, 4290, 4581], 'aberrant': [1263], 'altered': [1267, 3018], 'cellular': [1268, 2226, 2728, 3337, 3384], 'Animals–All': [1270], 'animal': [1271, 1282], 'experiments': [1272], 'were': [1273, 1301, 1338, 1349, 1413, 1423, 1441, 1472, 1498, 1505, 1514, 1527, 1678, 1763, 1820, 1853, 1877, 1904, 1918, 1966, 1984, 2008, 2016, 2108, 2118, 2184, 2230, 2275, 2345, 2354, 2398, 2469, 3375, 3393, 4191, 4477], 'conducted': [1274], 'compliance': [1276], 'with': [1277, 1434, 1474, 1488, 1544, 1580, 1609, 1662, 1971, 2018, 2053, 2245, 2264, 2296, 2372, 2453, 2605, 2851, 2866, 3659, 3880, 3952, 3972, 4093, 4106, 4128, 4178, 4210, 4232, 4321, 4446, 4513, 4727, 4739, 5004], 'CNRS': [1279], 'on': [1281, 2420, 3135], 'ethics.': [1283], 'mice': [1285, 1343, 2590, 2863, 3021], 'C57Bl/6j': [1288], 'background': [1289], '(kindly': [1290], 'provided': [1291], 'Bradfield,': [1295], 'University': [1296], 'Wisconsin,': [1298], 'Madison,': [1299], 'WI)': [1300], 'used': [1302, 1375, 2276], '8–12': [1304], 'weeks': [1305], 'age,': [1307], 'before': [1308, 4101], 'develop': [1310], 'arthropathy': [1311], '(25Bunger': [1312, 2760], 'M.K.': [1313, 2761, 2785], 'Walisser': [1314, 2762], 'J.A.': [1315, 2763], 'Sullivan': [1316, 2764], 'Manley': [1318, 2766], 'Moran': [1320, 2768, 2788], 'Kalscheur': [1322, 2770], 'V.L.': [1323, 2771], 'Colman': [1324, 2772], 'R.J.': [1325, 2773], 'Bradfield': [1326, 2774, 2800, 4972], 'C.A.': [1327, 2775, 2801], 'Genes.': [1328, 2776], 'Dev.': [1331, 2779], '41:': [1333, 2781], '122-132Google': [1334, 2782], 'Heterozygous': [1336], 'animals': [1337, 2869, 3184, 4189, 4200, 4219, 4562], 'crossed': [1339], 'generate': [1341, 1645], 'wild': [1345, 1407, 1685, 1736, 2867, 2979, 3013, 3210, 4066, 4090], 'type': [1346, 1686, 1737, 2868, 2980, 3014, 3211, 4067, 4091], 'littermates.': [1347], 'Animals': [1348], 'housed': [1350], '12-h': [1353], 'light/12-h': [1354], 'dark': [1355], '(light/dark': [1357], '12:12)': [1358], 'temperature-': [1361], 'humidity-controlled': [1363], 'environment': [1364], 'fed': [1366], 'ad': [1367], 'libitum.': [1368], 'Zeitgeber': [1369, 1402], 'time': [1370, 1403, 4119, 4196], '0': [1371, 1398, 2613], '(ZT0)': [1372], '5The': [1373], 'abbreviations': [1374], 'are:': [1376], 'ZTZeitgeber': [1377], 'timesiRNAsmall': [1378], 'RNAWTwild': [1380], 'type.': [1381, 1408], 'lights': [1384], 'on.': [1385], 'For': [1386], 'constant': [1388, 1396, 2593, 2611, 2615, 3180], 'darkness': [1389, 1397, 2594, 2612, 2616], 'experiment,': [1390], 'light': [1391], 'kept': [1393, 2591], 'off': [1394], '24': [1400, 2471], 'h.': [1401, 1467, 2342], 'RNA': [1406, 2391, 2394], 'Culture–NIH': [1410], '3T3': [1411], 'from': [1414, 1596, 1603, 1642, 1694, 1881, 2589, 2847, 3699, 4222, 4291, 4324], 'ATCC': [1415], 'grown': [1417, 1442], 'under': [1418], 'standard': [1419, 2103], 'conditions.': [1420], 'C2C12': [1421, 1440, 3332, 3373], 'maintained': [1424], 'growth': [1426, 4868], 'medium': [1427, 1433, 1450, 1456, 1462, 1485, 1492, 1542, 1571, 2445, 2451], 'consisting': [1428, 1451], "Dulbecco's": [1430, 1453, 1489], 'modified': [1431, 1454, 1490], "Eagle's": [1432, 1455, 1491], '10%': [1435, 1545], 'fetal': [1436, 1476, 1546, 1575], 'bovine': [1437, 1477, 1560], 'serum.': [1438, 1460, 1496], 'Undifferentiated': [1439], 'confluence': [1444], 'then': [1446, 1483, 1854, 2092, 4462], 'transferred': [1447, 2237], 'plus': [1457, 1493, 2416], '2%': [1458, 1494], 'horse': [1459, 1495], 'Differentiation': [1461], 'changed': [1464, 2447], 'every': [1465, 1500], '48': [1466, 1987], 'After': [1468, 1568, 2294, 2439, 4335], '10': [1469, 2067, 2077, 2083], 'days,': [1470], 'stimulated': [1473, 3254], '50%': [1475], 'serum': [1478, 1548, 1577, 3379], '2': [1480, 2256], 'h,': [1481, 1502, 2257, 4437], 'replaced': [1487], 'Cells': [1497, 1526, 1983, 2468], 'collected': [1499, 2470], '4': [1501, 2262, 2465, 4099], 'extracts': [1504], 'prepared': [1506], 'analysis.': [1511, 2095], 'Primary': [1512], 'isolated': [1515], 'situ': [1518], 'perfusion': [1519], 'procedure': [1520], 'purified': [1522], 'Liberase': [1523], '(Roche': [1524, 2023], 'Diagnostics).': [1525], 'plated': [1528], '2.5': [1530], '×': [1531], '104': [1532], 'cells/cm2': [1533], 'collagen-coated': [1535], '35-mm': [1536, 2431], 'culture': [1537, 4422], 'dishes': [1538], "William's": [1540, 2449], 'E': [1541, 2450, 3225, 3988], 'supplemented': [1543, 1579, 2452], 'calf': [1547, 1576], '(v/v),': [1549], '100': [1550, 1553], 'IU': [1551], 'penicillin,': [1552], 'mg/ml': [1554], 'streptomycin,': [1555], '5': [1557, 2454], 'μg': [1558, 2455], 'insulin': [1561, 2457], '37': [1563], '°C': [1564, 2087, 2263], '5%': [1566], 'CO2.': [1567], 'attachment,': [1570], 'renewed': [1573], 'without': [1574], '1': [1581, 2210, 2327, 2335, 2362, 2459], 'μm': [1582, 2058, 2460], 'dexamethasone.': [1583, 2461], 'Plasmid': [1584], 'Construction': [1585], 'Cotransfection': [1587, 3945], 'Assays–A': [1588], '2240-bp': [1589, 3765], 'fragment': [1590, 1641, 1712, 3767], 'upstream': [1591, 4048], 'first': [1594, 1700, 2892, 3682], 'exon': [1595], 'amplified': [1602, 1878, 2061], 'genomic': [1605], 'PCR': [1608, 1880, 2065, 2580], 'following': [1611, 1761, 1836, 1887, 2064, 2116, 2272, 4375], 'primers:': [1612, 1837, 1888], 'p21prom,': [1613], 'forward,': [1614, 1766, 1772, 1778, 1784, 1791, 1797, 1839, 1845, 1890, 1896, 2121, 2127, 2133, 2139, 2145, 2151, 2157, 2163, 2169, 2175], '5′-GCTCGAGTGTGTGCCTGGGGTGTGTATGTGTCAGG-3′;': [1615], 'reverse,': [1617, 1769, 1775, 1781, 1787, 1794, 1800, 1842, 1848, 1893, 1899, 2124, 2130, 2136, 2142, 2148, 2154, 2160, 2166, 2172, 2178], '5′-CCAAGCTTCCCTCCCCCACACCTGGGCTATTCTCT-3′,': [1618], 'cloned': [1620], 'HindIII': [1622], 'Pst1': [1624], 'front': [1626], 'luciferase': [1629, 1993, 3775], 'reporter': [1630, 1676, 1719, 1722, 1972, 3776, 3797, 3814, 3859, 3949], 'pGL3': [1634], 'basic': [1635], 'vector': [1636, 1926], 'containing': [1637, 1684, 1717, 2189, 3861], 'Sac1-HindIII': [1639], 'polylinker': [1640], 'pBKS': [1643], 'p21Prom::Luc': [1647, 1660, 3813], 'construct.': [1648], 'promoter': [1651, 1697, 2890, 3680, 3771, 3855, 3887, 4137], 'deletion': [1652, 3829], 'construct': [1653, 1661, 1863, 3860, 3950], 'p21PromΔ1663::Luc': [1654], 'digesting': [1658], 'SpeI': [1663], 'NheI': [1665], 'religation.': [1667], '(proRORE)4x-TATA::Luc,': [1669, 1765], '(proROREmut)4x-TATA::': [1670], 'Luc,': [1671, 1790], '(intRORE)4x-TATA::Luc,': [1672, 1777], '(intROREmut)4x-TATA::': [1674], 'Luc': [1675], 'vectors': [1677, 1723, 1813, 1865, 1979], 'made': [1679], 'annealing': [1681], 'phosphorylated': [1682], 'oligonucleotides': [1683, 1762], 'or': [1687, 1698, 1908, 2501, 3899, 4338, 4488, 4515], 'mutated': [1688, 1808, 3992], 'RORE': [1689, 1740, 1802, 3675, 3932, 3941, 4131], 'elements': [1690, 1803, 3629, 3804, 3993, 4012], 'surrounding': [1692], 'sequences': [1693, 2397], '(proRORE)': [1696], 'intron': [1701, 2893, 3683], '(intRORE)': [1702], 'ligating': [1704], 'four': [1705], 'copies': [1706, 1731], 'resulting': [1709, 1851, 1902], 'double': [1710, 4560], 'strand': [1711], 'into': [1713, 1860, 1913], 'TATA': [1715], 'box': [1716], 'pGL2': [1718], 'plasmid.': [1720], 'Control': [1721], 'ROR': [1725, 3506, 3631, 3652, 3707, 4019], 'REV-ERB': [1727, 3504, 3709, 4021], 'contained': [1729, 3817], 'three': [1730, 3136], 'previously': [1734, 1929, 2489, 3732, 3938], 'described': [1735, 1928], 'consensus': [1739, 3637, 3802, 3940, 3974], '(26Burke': [1741], 'Downes': [1743], 'Carozzi': [1745], 'Giguere': [1747], 'Muscat': [1749], 'G.E.': [1750], 'Nucleic': [1751], 'Acids': [1752], '1996;': [1754], '3481-3489Crossref': [1756], 'used:': [1764, 2119], '5′-GATCTGAGGAGGCCTGTCTAGGTCAGCTAAATCCGAGGAG-3′;': [1767], '5′-GATCCTCCTCGGATTTAGCTGACCTAGACAGGCCTCCTCA-3′;': [1770], '(proROREmut)4x-TATA::Luc,': [1771], '5′-GATCTGAGGAGGCCTGTCTAGAGTAGCTAAATCCGAGGAG-3′;': [1773], '5′-GATCCTCCTCGGATTTAGCTACTCTAGACAGGCCTCCTCA-3′;': [1776], '5′-GATCTCCCGCGCGGCACAGTGACCTATTTGGCGGGCACAG-3′;': [1779], '5′-GATCCTGTGCCCGCCAAATAGGTCACTGTGCCGCGCGGGA-3′;': [1782], '(intROREmut)4x-TATA::Luc,': [1783], '5′-GATCTCCCGCGCGGCACAGTACTCTATTTGGCGGGCACAG-3′;': [1785], '5′-GATCCTGTGCCCGCCAAATAGAGTACTGTGCCGCGCGGGA-3′;': [1788], '(consRORE)3x-TATA::': [1789], '5′-GATCTGACTGATCCATAAGTAGGTCAGGATCCTAGCAG-3′;': [1792], '5′-GATCCTGCTAGGATCCTGACCTACTTATGGATCAGTCA-3′;': [1795], '(consROREmut)3x-TATA::Luc,': [1796], '5′-GATCTGACTGATCCATAAGTAGAGTAGGATCCTAGCAG-3′;': [1798], '5′-GATCCTGCTAGGATCCTACTCTACTTATGGATCAGTCA.': [1801], 'bold,': [1806], 'nucleotides': [1809], 'underlined.': [1811], 'Expression': [1812, 2106], 'RORα4': [1815, 3660, 3823, 3955, 4061, 4248], '(NM_134262)': [1816], 'RORγ': [1818, 1844, 2132, 3662, 3809, 3875, 3892, 3953, 4082, 4113, 4136], '(NM_005060)': [1819], 'obtained': [1821, 3883, 3971], 'amplification': [1823], 'respective': [1826, 1873], 'open': [1827, 1874], 'reading': [1828, 1875], 'frames': [1829, 1876], 'HepG2': [1831], 'cDNA': [1833, 1884, 2039], 'RORα4,': [1838, 2126, 3877, 4038], '5′-GCGCTTAAATGATGTATTTTGTGATCGC-3′;': [1840], '5′-CATTTACCCATCAATTTGCATTGCTG;': [1843], '5′-GGGAGCTGCACCATGGACAGGGC-3′;': [1846], '5′-GGGAGAGGCAAGGAGTCCCTCTTCC.': [1849], 'fragments': [1852, 1903], 'digested': [1855, 1905], 'EcoRI': [1857], 'ligated': [1859, 1912], 'pcDNA3.1.': [1861, 1914], 'To': [1862, 2730, 3110, 3925, 4471], 'REVERBα': [1867], '(NM_145434)': [1868], 'REVERBβ': [1870], '(NM_011582),': [1871], 'REV-ERBα,': [1889], '5′-GGTGAAGACATGACGACCCTGGACTCC-3′;': [1891], '5′-CGGGTCACTGGGCGTCCACCCGGAAG-3′;': [1894], 'REVERBβ,': [1895], '5′-CGCGGATCCCACCATGGAGCTGAACGCAGGAGG-3′;': [1897], '5′-CGCGGATCCTTAAGGATGAACTTTAAAGGC-3′.': [1900], 'NotI': [1907], 'BamHI,': [1909], 'respectively,': [1910, 3203, 3878], 'All': [1915], 'constructs': [1917], 'verified': [1919], 'sequencing.': [1921], 'CLOCK': [1922], 'BMAL1': [1924, 2877, 4607], '(27Grechez-Cassiau': [1930], 'Lacoche': [1934, 2549], 'Teboul': [1936, 2551], 'Azmi': [1938, 2553], 'Taneja': [1944, 2559], '279:': [1952, 2567], '1141-1150Abstract': [1953, 2568], '(71)': [1961, 2576], 'NIH3T3': [1964], 'cotransfected': [1967], '7': [1969], 'h': [1970, 1988, 2441, 2466, 2472, 3397, 4100], '(100': [1973, 2426], 'ng)': [1974, 1978], '(300': [1977], 'Lipofectamine': [1981, 2437], '(Invitrogen).': [1982], 'incubated': [1985, 2244], 'fresh': [1990], 'medium,': [1991], 'determined': [1996], 'Promega': [1998], 'reagents': [1999, 4988], 'Berthold': [2002], 'Centro': [2003], 'LB960': [2004], 'luminometer.': [2005], 'Luciferase': [2006], 'normalized': [2009, 2109, 2387], 'total': [2011, 2389], 'concentrations.': [2013], 'Real-time': [2014, 2579], 'PCR–Measurements': [2015], 'performed': [2017, 2429], 'Cycler': [2021], '1.5': [2022, 2195], 'Applied': [2024], 'Science,': [2025], 'Meylan,': [2026], 'France)': [2027], 'SYBR': [2029, 2048], 'green': [2030], 'I': [2031], 'dye': [2032], 'detection': [2033], 'according': [2034, 2306], "manufacturer's": [2037, 2309], 'recommendations.': [2038], 'added': [2041, 2464], 'reaction': [2044], 'mixture': [2045, 2219], '(Faststart': [2046], 'Green': [2049], 'I;': [2050], 'Roche': [2051], 'Diagnostics)': [2052], 'appropriate': [2054], 'primers': [2055, 2117], '0.5': [2057, 2206, 2213], 'each': [2059, 2421], 'conditions:': [2066], 'min': [2068], '95': [2070, 2075], '°C,': [2071, 2076, 2081], '30': [2072], 's': [2073, 2078, 2084], '65': [2080], '72': [2086], '45': [2089], 'cycles': [2090], 'melting': [2093], 'curve': [2094, 2104], 'Relative': [2096], 'abundance': [2098], 'calculated': [2100], 'method.': [2105], 'levels': [2107, 2112, 2585, 2846, 3181, 4095, 4786], '36B4.': [2114], 'p21,': [2120, 2508, 2715, 4050, 4104], '5′-GCAGACCAGCCTGACAGATTT-3′;': [2122], '5′-GAGAGGGCAGGCAGCGTAT-3′;': [2125], '5′-CGCAGCGATGAAAGCTCA-3′;': [2128], '5′-TTGGACATCCGACCAAACTT-3′;': [2131], '5′-TTTTGAGGAAACCAGGCATC-3′;': [2134], '5′-CCACATCTCCCACATTGACTTC-3′;': [2137], 'Rev-erbα': [2138, 3533, 3556, 3646, 4179, 4226], '5′-AACCTCCAGTTTGTGTCAAGGT-3′;': [2140], '5′-GATGACGATGATGCAGAAGAAG-3′;': [2143], 'Rev-erbβ': [2144, 3535, 4042], '5′-TTCCAGTAGGTGGATGTTCTCA-3′;': [2146], '5′-CTGCTGGGGTAAAACTCATTG-3′;': [2149], 'p53,': [2150, 2900], '5′-GCTTCTCCGAAGACTGGATGA-3′;': [2152], '5′-GACACTCGGAGGGCTTCACT-3′;': [2155], 'Wee1,': [2156, 3139, 4589], '5′-GAGCGTATTTTAATGATTCC-3′;': [2158], '5′-AGAGCCAGCCAATGGTTTT-3′;': [2161], 'Cdk6,': [2162, 3140], '5′-GGCAAAGACCTACTTCTGAAATG-3′;': [2164], '5′-GCCAATGTGTTCAGATGACG-3′;': [2167], 'Ccne2,': [2168, 3189], '5′-GCATCAGTATGAGATTAGGAATTG-3′;': [2170], '5′-CAGAATGCAGAACTTGAAAATGT-3′;': [2173], '36B4,': [2174], '5′-GCTGATGGGCAAGAACACCA-3′;': [2176], '5′-CCCAAAGCCTGGAAGAAGGA-3′.': [2179], 'Western': [2180], 'Blot': [2181], 'Analysis–Harvested': [2182], 'lysed': [2185, 2355], 'buffer': [2188, 2247], '20': [2190], 'mm': [2191, 2196, 2202, 2207, 2211, 2214, 2358, 2363], 'Hepes': [2192], 'pH': [2193, 2360], '7.9,': [2194], 'MgCl2,': [2197], '0.42': [2198], 'm': [2199], 'NaCl,': [2200], '0.2': [2201], 'EDTA,': [2203], '25%': [2204], 'glycerol,': [2205], 'phenylmethylsulfonyl': [2208], 'fluoride,': [2209], 'NaF,': [2212], 'dithiothreitol,': [2215, 2364], 'protease': [2217], '(10': [2220], 'μg/ml': [2221], 'aprotinin': [2222], 'pepstatin).': [2224], 'Total': [2225], 'proteins': [2227], '(50–100': [2228], 'μg/lane)': [2229], 'loaded,': [2231], 'separated': [2232], '12%': [2234], 'SDS-polyacrylamide': [2235], 'gels,': [2236], 'polyvinylidene': [2239], 'difluoride': [2240], 'membrane': [2241], '(Amersham': [2242, 2311, 2331], 'Biosciences),': [2243], '(5%': [2248], 'nonfat': [2249], 'dry': [2250], 'milk': [2251], 'phosphate-buffered': [2253], 'saline)': [2254], 'probed': [2259], 'overnight': [2260], 'antibodies': [2266, 2274], 'diluted': [2267], 'solution.': [2270], 'dilution': [2279], '1:100': [2281], '(Santa': [2284], 'Cruz': [2285], 'Biotechnology,': [2286], 'Sc-397)': [2287], '1:1000': [2289], 'EF-1α': [2291], '(Upstate': [2292], 'Biotechnology).': [2293], 'incubation': [2295], 'second': [2297], 'antibodies,': [2298], 'peroxidase': [2299], 'detected': [2302, 2381, 2989, 3668], 'enhanced': [2304], 'chemiluminescence': [2305], 'instructions': [2310], 'Biosciences)': [2312], 'LAS3000': [2316], 'imager': [2317], '(Fuji).': [2318], '[methyl-3H]Thymidine': [2319, 2462], 'Incorporation': [2320], 'Assay–DNA': [2321], 'synthesis': [2322, 2478], 'measured': [2324], 'adding': [2326], 'μCi': [2328], '[methyl-3H]thymidine': [2330], 'Biosciences,': [2332], '25': [2333], 'Ci/mmol,': [2334], 'mCi/ml)': [2336], '16–24': [2341], 'Radiolabeled': [2343], 'washed,': [2346], 'scraped,': [2347], 'centrifuged,': [2349], 'pellets': [2353], '50': [2357], 'Tris,': [2359], '7.8,': [2361], '0.1%': [2365], 'Triton': [2366], 'X-100': [2367], 'buffer.': [2368], 'precipitated': [2371], '15%': [2373], 'trichloroacetic': [2374], 'acid,': [2375], 'incorporated': [2378], 'radioactivity': [2379], 'liquid': [2383], 'scintillation': [2384], 'counting': [2385], 'proteins.': [2390], 'Interference–Small': [2392], '(siRNA)': [2395], 'oligonucleotide': [2396], 'follows:': [2400], 'siRNA': [2402, 2425, 4516], 'control,': [2403], 'sense,': [2404], '5′-GCAGACCAGCCUAACAGAU-3′,': [2405], 'antisense,': [2407, 2414], '5′-AUCUGUUAGGCUGGUCUGC-3′;': [2408], 'siRNA,': [2410], 'sense': [2411], '5′-CACGUGGCCUUGUCGCUGU-3′,': [2412], '5′-ACAGCGACAAGGCCACGUG-3′': [2415], 'two': [2417, 3479, 3538, 3621, 3672], '2′-deoxythymidine': [2418], 'overhangs': [2419], 'strand.': [2422], 'Transfection': [2423], 'nm)': [2427], 'plates': [2432], 'presence': [2435, 3873, 4483], '2000.': [2438], '16': [2440], 'incubation,': [2443], 'later.': [2467], 'later': [2473], 'assayed': [2475, 4478], 'expression.': [2481], 'Is': [2483], 'Clock-controlled': [2485], 'Gene–We': [2486], 'others': [2488], 'identified': [2490, 3930, 4133], 'genome-wide': [2492], 'analysis': [2493, 2581, 3513], 'known': [2511, 2903, 3146, 3525, 3559], '(18Grundschober': [2515], '27Grechez-Cassiau': [2545], 'confirmed': [2595], 'oscillator,': [2604], 'peak': [2606, 3550, 4094], 'trough': [2608], 'values': [2609], '8,': [2617], 'respectively': [2618, 3963], '(Fig.': [2619, 2870, 2990, 3185, 3223, 3451, 3689, 3805, 3826, 3841, 3856, 3889, 3964, 3976, 3986, 3997, 4078, 4110, 4201, 4451, 4802], '1A).': [2620], 'Genomic': [2621], 'analyses': [2622, 3113], 'very': [2633, 4584], 'few': [2634], '(10%)': [2635], 'clock-controlled': [2636, 2708, 3431], 'oscillate': [2638, 2913, 3319], 'more': [2640, 3655], 'than': [2641], 'one': [2642], 'tissue': [2643, 2705], '(28Delaunay': [2644], 'Trends': [2648], '18:': [2651], '595-597Abstract': [2652], '(88)': [2660], 'Profiling': [2663], 'different': [2664], 'organs': [2666], 'revealed': [2670], 'its': [2672, 2718, 2743], 'restricted': [2679], 'heart': [2685], 'displayed': [2689, 4183], 'similar': [2691, 3968, 4585], '(supplemental': [2695], 'information,': [2696], 'Fig.': [2697], 'S1).': [2698], 'observations': [2700, 3098], 'high': [2704, 4287, 4332], 'specificity': [2706], 'does': [2711, 3495], 'apply': [2713], 'possibly': [2716, 4230], 'because': [2717, 3543, 3713], 'related': [2722], 'essential': [2725], 'ubiquitous': [2727], 'test': [2731, 4032, 4472], 'genetically': [2732, 4031], 'genes,': [2739, 3138], 'next': [2741], 'analyzed': [2742, 3327, 4052], 'Bmal1-null': [2746], 'mice,': [2747, 4979], 'model': [2750, 3338], 'exhibits': [2752], 'profound': [2754], 'alteration': [2755, 3215], '29Bunger': [2784], 'Wilsbacher': [2786], 'L.D.': [2787], 'Clendenin': [2790], 'Radcliffe': [2792], 'L.A.': [2793], 'Simon': [2796], 'M.C.': [2797, 4945], '103:': [2804], '1009-1017Abstract': [2805], '(1198)': [2813], '30Rudic': [2816], 'Curtis': [2820], 'A.M.': [2821, 4352], 'Boston': [2822], 'Fitzgerald': [2828], 'PLoS.': [2830], '2:': [2833], 'e377Crossref': [2834], '(799)': [2837], 'A': [2840, 3453, 3828, 3858], 'dramatic': [2841], 'increase': [2842, 3786], 'ZT4': [2848], 'ZT16': [2850], '8–12-fold': [2852], 'overexpression': [2853, 3025], 'ZT8': [2855], 'observed': [2857, 3792, 4177, 4425], 'compared': [2865, 4512], '1B).': [2871], 'suggests': [2875, 4164], 'represses': [2878], 'transcription,': [2880], 'lack': [2882], 'cognate': [2884], 'E-box': [2885, 3803], 'element': [2886, 3975], 'makes': [2894], 'unlikely': [2895], 'direct': [2897, 3540, 3719, 4605], 'inhibitory': [2898], 'mechanism.': [2899], 'human': [2916], 'mucosa': [2918], '(17Bjarnason': [2919], '31el-Deiry': [2941], 'W.S.': [2942], 'Tokino': [2943], 'Velculescu': [2945], 'V.E.': [2946], 'Levy': [2947], 'D.B.': [2948], 'Parsons': [2949], 'Trent': [2951], 'J.M.': [2952], 'Lin': [2953], 'Mercer': [2955], 'W.E.': [2956], 'Kinzler': [2957], 'K.W.': [2958], 'Vogelstein': [2959], 'B.': [2960, 3291, 4917, 4949], '1993;': [2962], '75:': [2963], '817-825Abstract': [2964], '(7957)': [2970], 'identically': [2975], 'livers': [2981], 'significant': [2985, 3207, 3785, 4504], 'rhythmicity': [2986], 'can': [2987, 4343, 4780], '1C).': [2991], 'therefore': [2994], 'putative': [2997, 3539], 'p21.': [3001, 4660], 'Consistently,': [3002, 3555], 'recent': [3003], 'showed': [3005, 3204, 3994, 4551], 'neither': [3010, 3205], 'nor': [3017, 3213], 'Per2-null': [3020], 'Per1': [3024, 3801], 'colon': [3027], 'cancer': [3028, 4848], 'leads': [3030], 'inhibition': [3033, 4246], 'response': [3037, 3628, 3762, 3923, 3996, 4800], 'ionizing': [3039], 'radiation': [3040], 'independently': [3041], '(19Fu': [3044, 3735, 4869], '32Gery': [3068], 'Komatsu': [3070, 4747], 'Baldjyan': [3072, 4749], 'Yu': [3074, 4751], 'Koo': [3076, 4753], 'Koeffler': [3078, 4755], 'H.P.': [3079, 4756], '22:': [3083, 4760], '375-382Abstract': [3084, 4761], '(468)': [3092, 4769], 'our': [3097, 3112], 'strongly': [3099, 4373], 'regulate': [3104], 'p53-independent': [3108], 'pathway.': [3109], 'extend': [3111], 'interactions': [3116], 'liver,': [3125, 4123, 4281, 4370], 'investigated': [3128], 'effect': [3130], 'Bmal1': [3133, 3486, 3546, 4025, 4046, 4077], 'mutation': [3134, 4574, 4667], 'Ccne2.': [3142], 'transition': [3152, 4596, 4793], 'intermediate': [3178], '1D).': [3186], 'Cdk6': [3187], 'encode': [3191], 'involved': [3195], 'G1/S': [3201], 'transition,': [3202], 'mutant': [3221, 3830, 4561], '1,': [3224], 'F).': [3227, 3990], 'short-lived': [3233], 'molecule': [3234], 'undergoes': [3236], 'proteasomal': [3237], 'degradation': [3238], 'consequently': [3242], 'nearly': [3243, 4192], 'undetectable': [3244, 4193, 4366], 'adult': [3246, 4369], 'unless': [3249], 'arrest': [3252], '(33Bloom': [3255], 'Amador': [3257], 'Bartolini': [3259], 'DeMartino': [3261], 'Pagano': [3263], '115:': [3267], '71-82Abstract': [3268], '(267)': [3276], '34Jascur': [3279], 'Brickner': [3281], 'Salles-Passador': [3283], 'I.': [3284], 'Barbier': [3285], 'El': [3287], 'Khissiin': [3288], 'Smith': [3290, 3357], 'Fotedar': [3292, 3294], '17:': [3299], '237-249Abstract': [3300], '(110)': [3308], 'As': [3311], 'found': [3317], 'cardiac': [3322], 'muscles,': [3325], 'cells,': [3333], 'terminal': [3342, 4318], 'induced': [3350, 4374], '(35Guo': [3351], 'K.': [3352, 3360], 'Wang': [3353], 'Andres': [3355], 'Walsh': [3359], '1995;': [3364], '3823-3829Crossref': [3366], '(365)': [3369], 'Differentiated': [3372], 'myotubes': [3374, 3434], 'subjected': [3376], 'shock': [3380], 'synchronize': [3382], 'level': [3392], 'monitored': [3394], '52': [3396], '(36Nagoshi': [3398], 'Saini': [3400], 'Bauer': [3402], 'Laroche': [3404], 'Naef': [3406], '119:': [3412], '693-705Abstract': [3413], '(789)': [3421], 'Results': [3424, 4493], 'mirrors': [3446], '2,': [3452, 4731], 'B).': [3455], 'Altogether,': [3456, 4002], 'these': [3457, 3478, 4003, 4275, 4773, 4811], 'demonstrate': [3459, 4005], 'output': [3471], 'addition': [3473], 'differentially': [3482], 'affected': [3483, 4072], 'mutation.': [3487], 'They': [3488], 'further': [3489], 'regulatory': [3492], 'directly': [3497, 3697], 'involve': [3498, 3921], 'component': [3502, 4844], 'BMAL1.': [3503], 'Nuclear': [3507], 'Receptors': [3508], 'Regulate': [3509], 'Expression–A': [3511], 'close': [3512], 'relationship': [3517], 'profiles': [3520, 4056], 'other': [3524], 'suggested': [3528, 3692, 3909], '(NR1D2)': [3536], 'targets,': [3547], 'both': [3549], 'when': [3551], 'low.': [3554], 'CLOCK:BMAL1': [3563, 3728], 'heterodimer': [3564, 3729], '37Triqueneaux': [3593], 'Thenot': [3595], 'Kakizawa': [3597], 'Antoch': [3599, 4690], 'M.P.': [3600, 4691], 'Safi': [3601], 'Endocrinol.': [3611], '33:': [3613], '585-608Crossref': [3614], 'repressors': [3622], 'bind': [3623], 'same': [3626, 3812], '(termed': [3635], 'RORE;': [3636], 'sequence:': [3638], 'WAWNTRGGTCA),': [3639], 'contrast,': [3642, 3808, 4081], 'activates': [3643], 'transcription.': [3644], 'Reverbβ': [3648, 4228], 'ubiquitously': [3650], 'expressed,': [3651], 'patterns,': [3658], '(NR1F3)': [3663], 'being': [3664], 'isotypes': [3667], 'liver.': [3670], 'Interestingly,': [3671, 4715], 'evolutionary': [3673], 'conserved': [3674], 'regions': [3684], '3A).': [3690], 'result': [3698, 4458], 'alternative': [3701], 'activation': [3702, 3840, 3985], 'repression': [3704], 'mediated': [3705, 3905], 'proteins,': [3710], 'respectively.': [3711], 'exclude': [3717], 'c-myc': [3734], 'tested': [3760], '5′': [3766], 'fused': [3772], '(p21Prom::Luc': [3778], 'construct)': [3779, 3836], 'cotransfection': [3782], 'assay.': [3783], 'No': [3784], 'over': [3787], 'basal': [3788], 'contrast': [3794], 'driven': [3799], '3B).': [3806], 'In': [3807, 4080, 4238, 4520], 'transactivated': [3810], 'construct,': [3815], 'proRORE,': [3819], '∼2.5-fold,': [3821], 'whereas': [3822, 4438], 'did': [3824], '3C).': [3827, 3842, 3857], 'lacking': [3831], 'proRORE': [3833, 3864, 3908], 'site': [3834], '(p21PromΔ1663::Luc': [3835], 'abolished': [3837], 'RORγ-dependent': [3839, 3850, 4295], 'Both': [3843], 'REV-ERBβ': [3846, 3980], 'antagonize': [3848], 'transactivation': [3851], 'multimerized': [3863], '((proRORE)4x-TATA::Luc)': [3865], '2.2-': [3868], '1.6-fold': [3870], 'consistently': [3879], 'full': [3886], 'sequence': [3888], '3D).': [3890], 'Similarly,': [3891], 'antagonized': [3895, 4168], 'coexpressing': [3897], 'REV-ERBβ.': [3900, 4172, 4304], 'relatively': [3902], 'modest': [3903], 'induction': [3904, 4441], 'part': [3911], 'if': [3912], 'may': [3920, 4268, 4413, 4645], 'element(s).': [3924], 'address': [3926], 'issue,': [3928], 'intronic': [3931], '(intRORE),': [3933], 'matches': [3936], 'defined': [3939], 'sequence,': [3942], 'tested.': [3944], '((intRORE)4x-TATA::Luc)': [3948], 'together': [3951, 4127, 4209], 'resulted': [3956, 4563], '2-': [3959], '9-fold': [3961], 'activation,': [3962, 4296], '3E),': [3965], '3F).': [3977], 'significantly': [3981, 4071, 4115, 4433], 'repressed': [3982, 4300], 'ROR-dependent': [3984], '3,': [3987, 3998], 'Corresponding': [3991], 'D': [3999], 'E).': [4001], 'locus': [4009], 'contains': [4010], 'functional': [4011, 4130], 'specify': [4014], 'responsiveness': [4016], 'components.': [4023], 'Mutation': [4026], 'Disrupts': [4027], 'ROR/REV-ERB': [4029, 4653], 'Balance–To': [4030], 'vivo': [4034], 'assumption': [4036], 'RORγ,': [4039], 'Rev-erbα,': [4040], 'downstream': [4044], 'throughout': [4057], '24-h': [4059], 'cycle.': [4060, 4825], 'loss': [4075, 4224, 4553], '4A).': [4079], 'exhibited': [4083], 'robust': [4085, 4185], 'ZT20,': [4097], 'hence': [4098], 'consistent': [4105], 'activating': [4108], '4B).': [4111], 'overexpressed': [4116], 'points': [4120, 4197], 'finding': [4125], 'that,': [4126], '(38Ueda': [4138], 'H.R.': [4139], 'Hayashi': [4140], 'Chen': [4142], 'W.': [4143], 'Sano': [4144], 'Machida': [4146], 'Shigeyoshi': [4148], 'Iino': [4150], 'Hashimoto': [4152], 'Nat.': [4154, 4897], '37:': [4157], '187-192Crossref': [4158], '(639)': [4161], 'autoregulation': [4167], 'and/or': [4171], 'opposite': [4174], 'situation': [4175], 'Rev-erbβ,': [4181], 'WT': [4188, 4449, 4469], '4,': [4202], 'C': [4203], 'D).': [4205], 'up-regulation': [4216], 'primarily': [4220], 'combined': [4231], 'RORγ.': [4237], 'context,': [4240], 'release': [4242], 'REV-ERB-dependent': [4245], 'likely': [4252, 4829], 'role.': [4256, 4273], 'Changes': [4257], 'unidentified': [4260], 'From': [4274], 'data,': [4276], 'propose': [4278], 'amplitude': [4288], 'RORa4-': [4293], 'Impaired': [4305], 'Proliferation': [4306], 'Hepatocytes–Unlike': [4309], 'large': [4311], 'number': [4312], 'types': [4315], 'undergo': [4317, 4647], 'associated': [4320], 'permanent': [4322], 'withdrawal': [4323], 'mature': [4328], 'quiescent': [4329], 'retain': [4331], 'potential.': [4334], 'partial': [4336, 4376], 'hepatectomy': [4337], 'acute': [4339], 'injury,': [4340], 'growth-arrested': [4341], 'rapidly': [4344], 'synchronously': [4346], 'enter': [4347], '(39Diehl': [4351], 'Front': [4353], 'Biosci.': [4354], '7:': [4356], 'e301-e314Crossref': [4357], 'normal': [4368], 'it': [4371, 4380, 4716], 'hepatectomy,': [4377], '(40Ilyin': [4385], 'Glaise': [4387], 'Gilot': [4389], 'Baffet': [4391, 4983], 'Guguen-Guillouzo': [4393], 'Physiol.': [4397], '285:': [4399], 'G115-G127Crossref': [4400], '(55)': [4403], 'Overexpression': [4406], 'thus': [4414], 'compromise': [4415], 'Using': [4418], 'system,': [4423], 'spontaneous': [4427], 'delayed': [4434, 4566], '∼24': [4436], 'higher': [4443], 'comparison': [4445], '5A).': [4452], 'If': [4453], 'overexpression,': [4461], 'reducing': [4463], 'would': [4466], 'rescue': [4467], 'phenotype.': [4470, 4586], 'hypothesis,': [4474], 'either': [4485], 'siRNA.': [4492], 'siRNA-mediated': [4497], 'caused': [4502], 'untreated': [4514], 'analogy': [4521], 'work': [4524], 'who': [4550], 'Cry1–/–/Cry': [4558], '2–/–': [4559], 'regeneration,': [4568], 'here': [4571], 'another': [4576], 'critical': [4591, 4807], 'proposed': [4602], 'CLOCK:': [4606], 'mediating': [4609], 'Our': [4638], 'pathway': [4654, 4801], 'targeting': [4655], 'Along': [4661], 'line,': [4663], 'Δ19': [4666], 'reduce': [4672], 'embryonic': [4676], 'fibroblasts': [4677], '(41Miller': [4678], 'B.H.': [4679], 'McDearmon': [4680], 'E.L.': [4681], 'Hayes': [4684], 'K.R.': [4685], 'Zhang': [4686], 'Andrews': [4688], 'J.L.': [4689], 'Walker': [4692], 'J.R.': [4693], 'Esser': [4694], '2007;': [4707], '104:': [4708], '3342-3347Crossref': [4709], '(398)': [4712], 'PER1': [4724], 'interacts': [4726], 'checkpoint': [4729, 4740], 'damage-activated': [4737], 'kinases': [4738], 'effectors': [4741], 'repair': [4744], '(32Gery': [4745], 'Collectively,': [4772], 'multiple': [4785], '6).': [4803], 'raises': [4805], 'issue': [4808], 'how': [4810], 'actions': [4812], 'coordinated': [4814], 'provide': [4816], 'optimal': [4818], 'aspects': [4827], 'become': [4831], 'particularly': [4832], 'relevant': [4833], 'context': [4836], 'pathologies': [4838], 'strong': [4842], 'recognized': [4846], 'accumulating': [4850], 'epidemiological,': [4851], 'clinical,': [4852], 'experimental': [4854], 'indicate': [4856], 'linked': [4864], 'tumor': [4866], '42Fu': [4893], 'C.C.': [4896], 'Cancer.': [4899], '3:': [4901], '350-361Crossref': [4902], '(597)': [4905], '43Filipski': [4908], 'King': [4912, 4938], 'V.M.': [4913, 4939], 'Wu': [4914], 'Claustrat': [4916, 4948], 'Grechez-Cassiau': [4918], 'Guettier': [4920], 'Hastings': [4922, 4950], 'M.H.': [4923, 4951], 'Francis': [4924], 'Cancer': [4926, 4956], '64:': [4929], '7879-7885Crossref': [4930], '(327)': [4933], '44Filipski': [4936], 'X.': [4941, 4947], 'Granda': [4942], 'Mormont': [4944], 'Inst.': [4957], '94:': [4959], '690-697Crossref': [4960], '(358)': [4963], 'We': [4966], 'thankful': [4968], 'Dr.': [4970], 'Christopher': [4971], 'generous': [4975], 'gift': [4976], 'Drs.': [4981], 'Georges': [4982], 'Stephan': [4985], 'Clavel': [4986], 'advice,': [4990], 'Sophie': [4993], 'Brangolo': [4994], 'expert': [4996], 'technical': [4997], 'assistance.': [4998], 'Download': [4999], '.pdf': [5000], '(.23': [5001], 'MB)': [5002], 'Help': [5003], 'pdf': [5005], 'files': [5006]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2084074983', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 25}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 22}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 25}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-08T14:08:55.660663', 'created_date': '2016-06-24'}
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