Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2083862783', 'doi': 'https://doi.org/10.1056/nejm200502243520825', 'title': 'APL during Gefitinib Treatment for Non–Small-Cell Lung Cancer', 'display_name': 'APL during Gefitinib Treatment for Non–Small-Cell Lung Cancer', 'publication_year': 2005, 'publication_date': '2005-02-23', 'ids': {'openalex': 'https://openalex.org/W2083862783', 'doi': 'https://doi.org/10.1056/nejm200502243520825', 'mag': '2083862783', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15728826'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm200502243520825', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM200502243520825?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM200502243520825?articleTools=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110163892', 'display_name': 'Akiko Uchida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I163770644', 'display_name': 'Okayama University', 'ror': 'https://ror.org/02pc6pc55', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I163770644']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akiko Uchida', 'raw_affiliation_strings': ['Okayama University'], 'affiliations': [{'raw_affiliation_string': 'Okayama University', 'institution_ids': ['https://openalex.org/I163770644']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066277266', 'display_name': 'Keitaro Matsuo', 'orcid': 'https://orcid.org/0000-0003-1761-6314'}, 'institutions': [{'id': 'https://openalex.org/I4210133851', 'display_name': 'Aichi Cancer Center', 'ror': 'https://ror.org/03kfmm080', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133851']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Keitaro Matsuo', 'raw_affiliation_strings': ['Aichi Cancer Center Hospital and Research Institute'], 'affiliations': [{'raw_affiliation_string': 'Aichi Cancer Center Hospital and Research Institute', 'institution_ids': ['https://openalex.org/I4210133851']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111977970', 'display_name': 'Mitsune Tanimoto', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mitsune Tanimoto', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.663514, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '352', 'issue': '8', 'first_page': '843', 'last_page': '843'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vinorelbine', 'display_name': 'Vinorelbine', 'score': 0.7218991}], 'concepts': [{'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.94726884}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93226874}, {'id': 'https://openalex.org/C2780350996', 'wikidata': 'https://www.wikidata.org/wiki/Q420532', 'display_name': 'Vinorelbine', 'level': 4, 'score': 0.7218991}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.6605298}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6383359}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.61052966}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.5937457}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.4587124}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.45308247}, {'id': 'https://openalex.org/C2909444961', 'wikidata': 'https://www.wikidata.org/wiki/Q738170', 'display_name': 'Small Cell Lung Carcinoma', 'level': 4, 'score': 0.4437551}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43916756}, {'id': 'https://openalex.org/C2779292878', 'wikidata': 'https://www.wikidata.org/wiki/Q738170', 'display_name': 'Small-cell carcinoma', 'level': 3, 'score': 0.42199096}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.40526578}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.093390375}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D015473', 'descriptor_name': 'Leukemia, Promyelocytic, Acute', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016609', 'descriptor_name': 'Neoplasms, Second Primary', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077156', 'descriptor_name': 'Gefitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015473', 'descriptor_name': 'Leukemia, Promyelocytic, Acute', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016609', 'descriptor_name': 'Neoplasms, Second Primary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm200502243520825', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM200502243520825?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15728826', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm200502243520825', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM200502243520825?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.84, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 3, 'referenced_works': ['https://openalex.org/W2092994996', 'https://openalex.org/W2098494369', 'https://openalex.org/W2128507218'], 'related_works': ['https://openalex.org/W4294934908', 'https://openalex.org/W4235474169', 'https://openalex.org/W2347934899', 'https://openalex.org/W2179477818', 'https://openalex.org/W2148494765', 'https://openalex.org/W2069409457', 'https://openalex.org/W2068701126', 'https://openalex.org/W2022628639', 'https://openalex.org/W1985597927', 'https://openalex.org/W165108920'], 'abstract_inverted_index': {'To': [0], 'the': [1, 19, 80], 'Editor:': [2], 'Gefitinib': [3], 'is': [4], 'an': [5], 'orally': [6], 'active': [7], 'inhibitor': [8], 'of': [9, 21, 82], 'tyrosine': [10], 'kinase': [11], 'epidermal': [12], 'growth': [13], 'factor,1': [14], 'with': [15, 29, 40, 49, 69], 'clinical': [16], 'effectiveness': [17], 'in': [18, 75], 'control': [20], 'non–small-cell': [22, 43], 'lung': [23, 44], 'cancer.': [24], 'We': [25], 'describe': [26], '3': [27], 'patients': [28, 39, 68], 'possible': [30], 'treatment-related': [31, 96], 'acute': [32], 'promyelocytic': [33], 'leukemia': [34], '(APL)': [35], 'among': [36], '108': [37], 'consecutive': [38], 'advanced,': [41], 'recurrent': [42], 'cancer': [45], 'who': [46], 'were': [47], 'treated': [48], 'gefitinib': [50], 'between': [51], 'November': [52], '2001': [53], 'and': [54, 88, 98], 'December': [55], '2004': [56], 'at': [57], 'our': [58], 'institution': [59], '(Table': [60], '1).': [61], 'Other': [62], 'than': [63], 'these': [64], 'three': [65], 'patients,': [66], 'no': [67], 'other': [70], 'cancers': [71], 'have': [72], 'been': [73], 'identified': [74], 'this': [76], 'cohort.': [77], 'Chemotherapy,': [78], 'including': [79], 'use': [81], 'topoisomerase': [83], 'II': [84], 'inhibitors': [85], '(e.g.,': [86], 'anthracyclines),': [87], 'radiotherapy': [89], 'are': [90], 'known': [91], 'as': [92], 'predisposing': [93], 'factors': [94], 'for': [95], 'APL,2': [97], 'all': [99], '.\xa0.\xa0.': [100]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083862783', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-06T05:04:55.758835', 'created_date': '2016-06-24'}