Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2083825454', 'doi': 'https://doi.org/10.1091/mbc.e03-08-0558', 'title': 'Human Topoisomerase IIα: Targeting to Subchromosomal Sites of Activity during Interphase and Mitosis', 'display_name': 'Human Topoisomerase IIα: Targeting to Subchromosomal Sites of Activity during Interphase and Mitosis', 'publication_year': 2004, 'publication_date': '2004-02-23', 'ids': {'openalex': 'https://openalex.org/W2083825454', 'doi': 'https://doi.org/10.1091/mbc.e03-08-0558', 'mag': '2083825454', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14978217', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/404031'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1091/mbc.e03-08-0558', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc404031?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027126006', 'display_name': 'Marta Agostinho', 'orcid': 'https://orcid.org/0000-0002-0414-7689'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Marta Agostinho', 'raw_affiliation_strings': ['Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084517708', 'display_name': 'José Rino', 'orcid': 'https://orcid.org/0000-0002-0637-4527'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'José Rino', 'raw_affiliation_strings': ['Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015996943', 'display_name': 'José Braga', 'orcid': 'https://orcid.org/0000-0002-2255-6486'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'José Braga', 'raw_affiliation_strings': ['Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074736370', 'display_name': 'Fernando Ferreira', 'orcid': 'https://orcid.org/0000-0001-5765-576X'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Fernando Ferreira', 'raw_affiliation_strings': ['Department of Morphology and Function, CIISA, Faculty of Veterinary Medicine, 1300-477 Lisbon, Portugal', 'Institute of Histology, Faculty of Medicine, University of Lisbon, 1649–028 Lisbon, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Institute of Histology, Faculty of Medicine, University of Lisbon, 1649–028 Lisbon, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}, {'raw_affiliation_string': 'Department of Morphology and Function, CIISA, Faculty of Veterinary Medicine, 1300-477 Lisbon, Portugal', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109394641', 'display_name': 'S. Steffensen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Soren Steffensen', 'raw_affiliation_strings': ['Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006150656', 'display_name': 'João Ferreira', 'orcid': 'https://orcid.org/0000-0002-8044-8926'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'João Ferreira', 'raw_affiliation_strings': ['Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Histology, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.', 'institution_ids': ['https://openalex.org/I141596103']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.069, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.845893, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '15', 'issue': '5', 'first_page': '2388', 'last_page': '2400'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'DNA and Nucleic Acid Chemistry', 'score': 0.9762, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/interphase', 'display_name': 'Interphase', 'score': 0.5692749}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8877927}, {'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.72321707}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.71780145}, {'id': 'https://openalex.org/C103435993', 'wikidata': 'https://www.wikidata.org/wiki/Q837783', 'display_name': 'Heterochromatin', 'level': 4, 'score': 0.6842057}, {'id': 'https://openalex.org/C29452124', 'wikidata': 'https://www.wikidata.org/wiki/Q835950', 'display_name': 'Interphase', 'level': 2, 'score': 0.5692749}, {'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.5615786}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49664026}, {'id': 'https://openalex.org/C2778354886', 'wikidata': 'https://www.wikidata.org/wiki/Q5113927', 'display_name': 'Chromosome segregation', 'level': 4, 'score': 0.45234597}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4174236}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.39861172}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.36212486}, {'id': 'https://openalex.org/C30481170', 'wikidata': 'https://www.wikidata.org/wiki/Q37748', 'display_name': 'Chromosome', 'level': 3, 'score': 0.33199543}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14710829}], 'mesh': [{'descriptor_ui': 'D004250', 'descriptor_name': 'DNA Topoisomerases, Type II', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D006570', 'descriptor_name': 'Heterochromatin', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D007399', 'descriptor_name': 'Interphase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008938', 'descriptor_name': 'Mitosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001324', 'descriptor_name': 'Autoantigens', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D001324', 'descriptor_name': 'Autoantigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001973', 'descriptor_name': 'Bromodeoxyuridine', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D001973', 'descriptor_name': 'Bromodeoxyuridine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001973', 'descriptor_name': 'Bromodeoxyuridine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020134', 'descriptor_name': 'Catalytic Domain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000076247', 'descriptor_name': 'Centromere Protein A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018385', 'descriptor_name': 'Centrosome', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D018385', 'descriptor_name': 'Centrosome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004250', 'descriptor_name': 'DNA Topoisomerases, Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004250', 'descriptor_name': 'DNA Topoisomerases, Type II', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004250', 'descriptor_name': 'DNA Topoisomerases, Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006570', 'descriptor_name': 'Heterochromatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006570', 'descriptor_name': 'Heterochromatin', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D006655', 'descriptor_name': 'Histone Deacetylases', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006655', 'descriptor_name': 'Histone Deacetylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006877', 'descriptor_name': 'Hydroxamic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006877', 'descriptor_name': 'Hydroxamic Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007399', 'descriptor_name': 'Interphase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042581', 'descriptor_name': 'Intranuclear Space', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042581', 'descriptor_name': 'Intranuclear Space', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008938', 'descriptor_name': 'Mitosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012319', 'descriptor_name': 'RNA Polymerase II', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D012319', 'descriptor_name': 'RNA Polymerase II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011929', 'descriptor_name': 'Razoxane', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011929', 'descriptor_name': 'Razoxane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1091/mbc.e03-08-0558', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc404031', 'pdf_url': 'https://europepmc.org/articles/pmc404031?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC404031', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14978217', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc404031', 'pdf_url': 'https://europepmc.org/articles/pmc404031?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1490231232', 'https://openalex.org/W1493549734', 'https://openalex.org/W1508389343', 'https://openalex.org/W1919687599', 'https://openalex.org/W1985376829', 'https://openalex.org/W1987325811', 'https://openalex.org/W1990035744', 'https://openalex.org/W1998475589', 'https://openalex.org/W1998582794', 'https://openalex.org/W1999656785', 'https://openalex.org/W2002493222', 'https://openalex.org/W2011270372', 'https://openalex.org/W2017183849', 'https://openalex.org/W2021691701', 'https://openalex.org/W2031676888', 'https://openalex.org/W2044142379', 'https://openalex.org/W2047632936', 'https://openalex.org/W2052668971', 'https://openalex.org/W2054925751', 'https://openalex.org/W2068688075', 'https://openalex.org/W2084250387', 'https://openalex.org/W2085711044', 'https://openalex.org/W2092396836', 'https://openalex.org/W20935937', 'https://openalex.org/W2100099919', 'https://openalex.org/W2110479470', 'https://openalex.org/W2113990896', 'https://openalex.org/W2115171989', 'https://openalex.org/W2121930828', 'https://openalex.org/W2123374199', 'https://openalex.org/W2135271276', 'https://openalex.org/W2139447901', 'https://openalex.org/W2140125310', 'https://openalex.org/W2146295682', 'https://openalex.org/W2147791710', 'https://openalex.org/W2155941870', 'https://openalex.org/W2158140180', 'https://openalex.org/W2162692975', 'https://openalex.org/W2171292691', 'https://openalex.org/W2341695868', 'https://openalex.org/W3152148302', 'https://openalex.org/W4236530034', 'https://openalex.org/W4254120264'], 'related_works': ['https://openalex.org/W2415278333', 'https://openalex.org/W2135491599', 'https://openalex.org/W2132818556', 'https://openalex.org/W2122811501', 'https://openalex.org/W2078893332', 'https://openalex.org/W2031489550', 'https://openalex.org/W2009781127', 'https://openalex.org/W1985078831', 'https://openalex.org/W1659509344', 'https://openalex.org/W1576499812'], 'abstract_inverted_index': {'Mammalian': [0], 'topoisomerase': [1], 'IIalpha': [2, 36, 44, 88, 130], '(topo': [3], 'IIalpha)': [4], 'plays': [5], 'a': [6, 24, 54, 113], 'vital': [7], 'role': [8], 'in': [9, 50, 53, 112, 125, 144], 'the': [10, 91, 105, 126, 145, 148], 'removal': [11], 'of': [12, 31, 34, 94, 104, 128, 147, 152], 'topological': [13], 'complexities': [14], 'left': [15], 'on': [16], 'DNA': [17], 'during': [18, 61], 'S': [19, 52], 'phase.': [20], 'Here,': [21], 'we': [22, 98], 'developed': [23], 'new': [25], 'assay': [26], 'to': [27, 78, 109, 123], 'selectively': [28], 'identify': [29], 'sites': [30, 151], 'catalytic': [32], 'activity': [33, 45, 153], 'topo': [35, 43, 87, 129], 'with': [37], 'subcellular': [38], 'resolution.': [39], 'We': [40, 81], 'show': [41, 83], 'that': [42, 69, 84, 100, 117], 'concentrates': [46, 89], 'at': [47, 58], 'replicating': [48], 'heterochromatin': [49, 60, 75], 'late': [51], 'replication-dependent': [55], 'manner': [56, 115], 'and': [57, 63, 116, 132, 154], 'centric': [59], 'G2': [62], 'M': [64], 'phases.': [65], 'Inhibitor': [66], 'studies': [67], 'indicate': [68], 'this': [70, 118], 'cell': [71], 'cycle-dependent': [72], 'concentration': [73], 'over': [74], 'is': [76, 120], 'sensitive': [77, 122], 'chromatin': [79], 'structure.': [80], 'further': [82], 'catalytically': [85, 101], 'active': [86], 'along': [90], 'longitudinal': [92], 'axis': [93], 'mitotic': [95], 'chromosomes.': [96], 'Finally,': [97], 'found': [99], 'inert': [102], 'forms': [103], 'enzyme': [106, 149], 'localize': [107], 'predominantly': [108], 'splicing': [110], 'speckles': [111], 'dynamic': [114], 'pool': [119], 'differentially': [121], 'changes': [124], 'activities': [127, 143], 'itself': [131], 'RNA': [133], 'polymerase': [134], 'II.': [135], 'Together,': [136], 'our': [137], 'data': [138], 'implicate': [139], 'several': [140], 'previously': [141], 'unsuspected': [142], 'partitioning': [146], 'between': [150], 'putative': [155], 'depots.': [156]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083825454', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T17:50:18.233389', 'created_date': '2016-06-24'}