Publication Information

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505, 567, 587, 610, 618, 653, 655, 663, 688, 696, 701, 724, 740, 747, 752, 826, 835, 843, 936, 1049, 1065, 1069, 1085, 1087, 1100, 1105, 1157, 1168, 1219, 1224, 1260, 1360, 1393, 1408, 1470, 1478, 1490, 1586, 1707, 1724, 1842, 1938, 1980, 1985, 2002, 2016, 2097, 2102, 2220, 2262, 2316, 2353, 2376, 2386, 2472, 2566, 2603, 2626, 2667, 2680, 2691, 2699, 2743, 2819, 2849, 2865, 2902, 2986, 2994, 3000, 3114, 3203, 3208, 3215, 3295, 3303, 3315, 3327, 3392, 3433, 3509, 3518, 3562, 3651, 3752, 3757, 3779, 3800, 3806, 3858, 3947, 3987, 3989, 4004, 4030, 4195, 4201, 4206, 4237, 4273, 4283, 4290, 4302, 4310, 4314, 4321, 4328, 4330, 4357, 4361, 4570, 4721, 4726, 4730, 4828, 4862, 4925, 4943, 4984, 5047, 5266, 5309, 5344, 5359, 5374, 5398], 'pancreatic': [10, 62, 206, 233, 285, 429, 588, 898, 1369, 1614, 2697, 3187, 3205, 3405, 4593, 4708, 5052, 5337], 'islet': [11, 234, 447, 589, 899, 2821, 2867, 3406, 5038], 'biology.': [13, 236, 1410], 'As': [14, 237, 3332, 3388, 5144], 'a': [15, 131, 238, 354, 527, 611, 689, 738, 744, 841, 867, 1057, 1063, 1179, 1210, 1271, 1361, 1402, 1468, 1476, 1488, 1498, 1654, 1740, 1882, 1888, 2271, 2627, 2839, 2951, 2984, 2995, 3213, 3247, 3393, 3431, 3441, 3506, 3645, 3815, 3863, 4215, 4241, 4255, 4268, 4707, 4956, 5014, 5034, 5233, 5240, 5319, 5341], 'result,': [16, 239], 'factors': [17, 240], 'that': [18, 38, 113, 177, 217, 241, 261, 336, 400, 440, 721, 861, 873, 924, 944, 947, 1171, 1262, 1356, 1386, 1399, 2222, 2573, 2750, 2913, 2920, 2999, 3358, 3443, 3526, 3817, 3921, 3960, 3976, 4334, 4459, 4585, 4695, 4841, 4916, 4959, 5244, 5347], 'modulate': [19, 242, 5061], 'these': [20, 173, 243, 396, 656, 1208, 3253, 3849, 3859, 4187, 4571], 'processes': [21, 244, 1237], 'great': [24, 247], 'interest': [25, 248], 'for': [26, 202, 249, 425, 516, 1062, 1390, 1902, 2093, 2191, 2213, 2236, 2305, 2329, 2340, 2466, 2485, 2514, 2773, 3104, 3111, 3250, 3498, 3739, 4232, 4338, 4430, 4678, 5322, 5333, 5366, 5387, 5395], 'the': [27, 39, 64, 69, 96, 136, 142, 152, 178, 184, 199, 250, 262, 287, 292, 319, 359, 365, 375, 401, 407, 422, 450, 456, 466, 478, 485, 494, 503, 510, 565, 650, 660, 686, 693, 702, 722, 874, 922, 1050, 1066, 1083, 1095, 1103, 1147, 1150, 1227, 1300, 1351, 1462, 1516, 1526, 1537, 1621, 1626, 1914, 1954, 1996, 2013, 2017, 2029, 2117, 2129, 2260, 2263, 2265, 2347, 2351, 2354, 2357, 2361, 2405, 2427, 2451, 2502, 2507, 2551, 2564, 2608, 2656, 2671, 2738, 2741, 2778, 2784, 2787, 2815, 2820, 2828, 2847, 2861, 2866, 2876, 2882, 2887, 2987, 3112, 3115, 3185, 3201, 3204, 3325, 3436, 3439, 3512, 3515, 3527, 3649, 3747, 3753, 3786, 3791, 3803, 3807, 3852, 3856, 3923, 3945, 3961, 3974, 3977, 4027, 4039, 4191, 4198, 4204, 4220, 4225, 4230, 4251, 4288, 4299, 4303, 4308, 4311, 4319, 4326, 4335, 4341, 4354, 4358, 4436, 4581, 4690, 4701, 4722, 4731, 4826, 4831, 4842, 4859, 4914, 4960, 5004, 5009, 5044, 5090, 5184, 5195, 5199, 5251, 5262, 5307, 5329, 5345, 5357, 5360, 5375, 5399], 'potential': [28, 251, 933, 3248, 4723], 'treatment': [29, 252, 1176, 3778], 'Type': [31, 254, 506, 2165], '2': [32, 255, 507, 1563, 2090, 2306, 2330, 2486], 'diabetes.': [33, 256], 'Here,': [34, 257], 'we': [35, 258, 1354, 1384, 2843, 3255, 3419, 3984, 4239, 4579], 'present': [36, 60, 259, 283, 1352, 3403, 4589], 'evidence': [37, 201, 260, 424, 4458, 4584, 4677], 'heterotrimeric': [40, 263, 4005, 4362], 'G': [41, 264, 619, 634, 869, 1071, 1088, 3990, 4006, 4363, 4684, 4928, 5349], 'protein': [42, 265, 620, 667, 1060, 1089, 1274, 1941, 2545, 2693, 3105, 3991, 4364, 4685], 'Gz': [43, 190, 203, 266, 413, 426, 1220, 1400, 3251, 3328, 3565, 3928, 4041, 4600, 4697, 4742, 5334], 'its': [45, 268, 2759, 3427, 4424, 5282], 'effectors,': [46, 269], 'including': [47, 270, 2935, 3223], 'some': [48, 271, 654, 1892, 5079], 'previously': [49, 272, 4603, 4737], 'thought': [50, 273], 'to': [51, 56, 189, 274, 279, 412, 472, 488, 502, 514, 573, 659, 832, 866, 932, 1093, 1108, 1143, 1149, 1226, 1380, 1719, 1748, 1789, 1948, 2041, 2065, 2185, 2251, 2326, 2344, 2396, 2403, 2416, 2482, 2549, 2572, 2584, 2674, 2757, 2845, 2885, 2911, 2924, 2998, 3005, 3329, 3362, 3369, 3429, 3438, 3446, 3487, 3489, 3514, 3559, 3820, 3854, 3881, 3927, 3954, 3999, 4208, 4224, 4292, 4316, 4351, 4599, 4682, 4700, 4711, 4739, 4741, 4847, 4927, 4955, 4970, 5060, 5088, 5151, 5157, 5235, 5247, 5328], 'be': [52, 275, 833, 895, 3560, 3997, 4918, 5260], 'confined': [53, 276], 'in': [54, 61, 82, 95, 121, 124, 183, 205, 215, 277, 284, 305, 318, 344, 347, 406, 428, 438, 455, 465, 470, 529, 571, 755, 897, 929, 1215, 1222, 1368, 1405, 1456, 1461, 1515, 1551, 1594, 1636, 1653, 1672, 1772, 1874, 1887, 2205, 2224, 2254, 2308, 2366, 2373, 2388, 2393, 2419, 2450, 2459, 2532, 2541, 2569, 2574, 2587, 2695, 2754, 2813, 2826, 2852, 2860, 2917, 2928, 3176, 3180, 3200, 3252, 3261, 3345, 3366, 3404, 3417, 3422, 3532, 3542, 3546, 3566, 3648, 3744, 3802, 3862, 3929, 3965, 4183, 4190, 4234, 4267, 4270, 4340, 4369, 4426, 4435, 4465, 4592, 4605, 4609, 4692, 4706, 4718, 4743, 4769, 4814, 4817, 4837, 4868, 4930, 4936, 4965, 5011, 5037, 5050, 5056, 5094, 5204, 5336, 5352], 'expression': [55, 278, 2694, 2745, 2760, 2825, 2851, 2856, 2895, 3199, 3314, 4272, 4285, 4332], 'neuronal': [57, 280, 4744], 'cells,': [58, 281, 3347, 4839], 'β-cells,': [63, 83, 207, 286, 306, 430, 2831, 3418], 'largest': [65, 288], 'cellular': [66, 289, 1940], 'constituent': [67, 290], 'islets': [70, 293, 756, 2698, 2755, 2905, 2959, 3002, 3182, 4870, 5053, 5206], 'Langerhans.': [72, 295], 'Furthermore,': [73, 296, 2893, 4595, 4808, 5078], 'signaling': [74, 204, 213, 297, 427, 436, 926, 1090, 1236, 1364, 3119, 3396, 3413, 3563, 3992, 4217, 5335], 'pathways': [75, 298, 927, 3861], 'upon': [76, 299], 'which': [77, 300, 1216, 2562, 2886, 3995, 4036, 5083], 'Gαz': [78, 85, 169, 221, 301, 308, 392, 444, 879, 937, 953, 1053, 1078, 1101, 1107, 1140, 1158, 1261, 1357, 1363, 1387, 1417, 1992, 2007, 2692, 2751, 2810, 2850, 2855, 2877, 2894, 2914, 3171, 3198, 3359, 3395, 3783, 3822, 3890, 4233, 4246, 4252, 4271, 4284, 4331, 4431, 4460, 4586, 4822, 5237, 5254, 5267], 'impacts': [79, 302], 'intact': [81, 304, 2958, 3531], 'activation': [86, 309, 1156, 1161, 1218], 'inhibits': [87, 310, 1159], 'both': [88, 311, 1082, 2814, 2827, 3170, 3338, 4588], 'cAMP': [89, 312, 1180, 2237, 2387, 2406, 2467, 3225, 3259, 3309, 3336], 'production': [90, 313, 3226, 3260], 'glucose-stimulated': [92, 102, 148, 155, 315, 325, 371, 378, 630, 725, 3224, 3258], 'Ins-1(832/13)': [97, 185, 320, 408, 1529, 2067, 2103, 2196, 2455, 2981, 3262, 3346, 3423, 3519, 3780, 3875, 3930, 3966, 4020, 4184, 4262, 4342, 4818, 4838, 4966], 'β-cell-derived': [98, 321, 1372, 2918, 2933, 3177, 4872], 'line.': [99, 127, 322, 350, 3535], 'Inhibition': [100, 323], 'by': [105, 158, 163, 328, 381, 386, 731, 1175, 1722, 1737, 1770, 1808, 1820, 1831, 1848, 1863, 1879, 1900, 1913, 1944, 1959, 2230, 2537, 2662, 2670, 2899, 3109, 3212, 3760, 3949, 4323, 4830, 4858, 4864, 5043], 'prostaglandin': [106, 329, 603], 'E': [107, 180, 330, 403, 562, 3748, 3792, 3962, 4221, 4703, 4962, 4972, 5030, 5189], '(PGE1)': [108, 331], 'is': [109, 160, 218, 332, 383, 441, 729, 860, 1055, 1141, 1172, 1388, 2563, 2752, 2811, 2915, 3415, 3444, 3530, 3746, 3814, 3818, 4345, 4421, 4456, 4461, 4587, 4714, 4835, 4856, 5041, 5183, 5198, 5245], 'pertussis-toxin': [110, 333], 'insensitive,': [111, 334], 'indicating': [112, 335], 'other': [114, 337, 475, 3370, 3451, 3567, 3885, 3939, 4466, 4848, 4865, 5256], 'Gαi': [115, 338, 703, 732, 876, 3371, 3452, 3886, 3940, 4359, 5241, 5257], 'family': [116, 339, 877, 1068], 'members': [117, 340, 1359, 3113, 3211, 3391, 3454, 3888, 4851, 5160, 5358, 5373], 'not': [119, 342, 3184, 3450, 3503, 3824, 3892, 4349], 'involved': [120, 343], 'this': [122, 125, 345, 348, 498, 1154, 2744, 3412, 3533, 3913, 4577, 4683, 4693, 4727], 'process': [123, 214, 346, 437, 499], 'Indeed,': [128, 351, 3777], 'overexpression': [129, 352], 'selective': [132, 355], 'deactivator': [133, 356], 'Gαz,': [135, 358, 2774, 3121, 3296, 3398, 3448, 4353], 'RGS': [137, 360, 1273, 4028, 4188, 4199, 4312, 4949], 'domain': [138, 361, 4200, 4313], 'RGSZ1,': [140, 363, 1270, 4031, 5315], 'blocks': [141, 364, 1081, 1682], 'inhibitory': [143, 366, 651], 'effect': [144, 367, 3319, 3352, 4305, 4327], 'PGE1': [146, 159, 369, 382, 2496, 3761, 3796, 3906, 3950, 3978, 4207, 4291, 4304, 4339, 5000], 'on': [147, 220, 370, 443, 750, 1207, 1713, 3872, 4306], 'secretion.': [150, 373], 'Finally,': [151, 374], 'inhibition': [153, 376, 723, 751, 1392, 3650, 3756, 3914, 3946, 4236, 4320, 4827, 4861], 'substantially': [161, 384], 'blunted': [162, 385], 'small': [164, 387, 646, 1070], 'interfering': [165, 388, 647], 'RNA-mediated': [166, 389], 'knockdown': [167, 390, 4329], 'expression.': [170, 393, 2232, 4247], 'Taken': [171, 394, 4297], 'together,': [172, 395, 4298], 'data': [174, 197, 397, 420, 1396, 4855], 'strongly': [175, 398, 1397, 3910, 4213], 'imply': [176, 399], 'endogenous': [179, 211, 402, 434, 3540, 3741, 4336, 4679, 4696, 4702, 4843, 4961], 'prostanoid': [181, 404, 3749, 3793, 3963, 4222, 4704, 4963], 'receptor': [182, 405, 3554, 3743, 3750, 3794, 3964, 3979, 4223, 4337, 4597, 4680, 4705, 4844, 4964, 5180], 'line': [187, 410, 1523, 1616, 2033, 2990, 4344, 4710], 'couples': [188, 411, 4846, 4969], 'predominantly': [191, 414, 3936, 3969, 3981, 4845], 'perhaps': [193, 416], 'even': [194, 417], 'exclusively.': [195, 418], 'These': [196, 419, 1395, 3192, 3355, 3523], 'provide': [198, 421, 4580, 5340], 'first': [200, 423, 3256, 4367, 4582, 5330], 'identify': [209, 432, 2777, 2783], 'an': [210, 433, 461, 857, 1850, 1962, 2217, 2762, 3740, 3798, 4715, 4812, 5057, 5178], 'receptor-mediated': [212, 435, 1217], 'β-cells': [216, 439, 448, 483, 511, 570, 1370, 3367, 3745, 5338], 'dependent': [219, 442], 'function.': [222, 445], 'Pancreatic': [446], 'sole': [451], 'producers': [452], 'body': [457], 'thus': [459], 'play': [460, 5351], 'homeostatic': [463], 'role': [464, 1404, 3249, 3647, 5036, 5321], 'response': [471, 572, 2955, 5093], 'glucose': [473, 492, 574, 5015], 'secretagogues.': [476], 'Normally,': [477], 'release': [479], 'from': [482, 493, 569, 940, 1146, 1422, 1533, 1581, 1620, 1995, 2116, 2155, 3098, 3435, 3511, 4219, 4939], 'induces': [484], 'peripheral': [486, 517], 'tissues': [487, 4467], 'take': [489], 'up': [490], 'available': [491], 'plasma.': [495], 'Disregulation': [496], 'can': [500, 1232, 3218, 3360, 3925, 3996, 4698], 'lead': [501, 4954], 'development': [504], 'diabetes,': [508], 'wherein': [509], 'unable': [513], 'compensate': [515], 'tissue': [518, 1710, 2207, 2256, 2421, 5264], 'resistance,': [520], 'either': [521, 1178, 3477, 3785], 'through': [522, 1265, 3550, 3564, 3938, 3982], 'inadequate': [523], 'function': [525, 2927, 3361, 3442, 3759, 3816, 4425], 'and/or': [526, 2239, 4463], 'decrease': [528, 564, 4269], 'mass': [531], '(1Lingohr': [532], 'M.K.': [533, 4664], 'Buettner': [534], 'R.': [535, 760, 1690, 1756, 3015, 3656, 3677, 3708, 4075, 4881], 'Rhodes': [536], 'C.J.': [537], 'Trends': [538], 'Mol.': [539, 713, 1038, 1340, 3633, 4013, 4141, 4538], 'Med.': [540, 5021, 5100], '2002;': [541, 1193, 1245, 2971, 3089, 3156, 3462, 3577, 3728, 3833, 4755], '8:': [542], '375-384Abstract': [543], 'Full': [544, 546, 678, 972, 974, 996, 998, 1020, 1022, 1126, 1128, 1196, 1198, 1248, 1250, 1289, 1291, 1322, 1324, 1447, 3139, 3141, 3159, 3161, 3288, 3465, 3467, 3580, 3582, 3715, 3836, 3838, 4056, 4058, 4084, 4086, 4169, 4171, 4758, 4760, 5134, 5136, 5221, 5223, 5300], 'Text': [545, 547, 679, 973, 975, 997, 999, 1021, 1023, 1127, 1129, 1197, 1199, 1249, 1251, 1290, 1292, 1323, 1325, 1448, 3140, 3142, 3160, 3162, 3289, 3466, 3468, 3581, 3583, 3716, 3837, 3839, 4057, 4059, 4085, 4087, 4170, 4172, 4759, 4761, 5135, 5137, 5222, 5224, 5301], 'PDF': [548, 680, 976, 1000, 1024, 1130, 1200, 1252, 1293, 1326, 1449, 3143, 3163, 3290, 3469, 3584, 3717, 3840, 4060, 4088, 4173, 4762, 5138, 5225, 5302], 'PubMed': [549, 583, 681, 773, 792, 806, 819, 853, 889, 916, 977, 1001, 1025, 1043, 1131, 1201, 1253, 1294, 1327, 1345, 1450, 1699, 1765, 1924, 2716, 2733, 2805, 2974, 3024, 3061, 3092, 3144, 3164, 3240, 3291, 3383, 3470, 3585, 3622, 3638, 3669, 3686, 3718, 3731, 3772, 3841, 4061, 4089, 4115, 4146, 4174, 4389, 4412, 4450, 4483, 4523, 4544, 4565, 4621, 4658, 4671, 4763, 4803, 4893, 4907, 5025, 5073, 5104, 5115, 5139, 5173, 5226, 5277, 5303], 'Scopus': [550, 774, 793, 807, 820, 890, 917, 978, 1002, 1026, 1044, 1132, 1202, 1254, 1295, 1328, 1346, 1700, 1766, 1925, 2717, 2806, 2975, 3025, 3062, 3093, 3145, 3165, 3241, 3384, 3471, 3586, 3623, 3639, 3670, 3732, 3773, 3842, 4062, 4090, 4116, 4147, 4175, 4390, 4413, 4451, 4484, 4524, 4545, 4622, 4659, 4672, 4764, 4804, 4894, 4908, 5026, 5074, 5105, 5116, 5140, 5174, 5227, 5278], '(156)': [551], 'Google': [552, 584, 682, 718, 776, 795, 809, 822, 854, 892, 919, 980, 1004, 1028, 1046, 1134, 1204, 1256, 1297, 1330, 1348, 1451, 1702, 1768, 1927, 2719, 2734, 2808, 2977, 3027, 3064, 3095, 3147, 3167, 3243, 3292, 3386, 3473, 3588, 3625, 3641, 3672, 3687, 3719, 3734, 3775, 3844, 4018, 4064, 4092, 4118, 4149, 4177, 4392, 4415, 4453, 4486, 4503, 4526, 4547, 4566, 4624, 4661, 4674, 4766, 4806, 4896, 4910, 5028, 5076, 5107, 5118, 5142, 5176, 5229, 5280, 5304], 'Scholar).': [553, 585, 683, 823, 1047, 1135, 1205, 1257, 1349, 1703, 2978, 3096, 3168, 3244, 3387, 3474, 3735, 3776, 4019, 4454, 4807, 4998, 5029, 5077, 5143, 5230], 'Certain': [554], 'hormones': [555], 'such': [556, 925, 5312], 'as': [557, 665, 1459, 1513, 2228, 2448, 2463, 2559, 2655, 3312, 5238, 5313], 'norepinephrine,': [558, 4976], 'somatostatin,': [559, 4977], 'galanin,': [560, 4979], 'prostaglandins': [563], '(2Sharp': [575, 845], 'G.W.': [576, 846, 4991], 'Am.': [577, 847, 4992], 'J.': [578, 672, 706, 768, 801, 848, 885, 911, 966, 983, 990, 1014, 1113, 1120, 1187, 1190, 1239, 1242, 1283, 1316, 1441, 1583, 2711, 2726, 2800, 2965, 3126, 3133, 3150, 3153, 3282, 3456, 3459, 3571, 3574, 3591, 3593, 3664, 3692, 3702, 3709, 3827, 3830, 4050, 4067, 4078, 4154, 4163, 4446, 4478, 4498, 4535, 4617, 4627, 4629, 4749, 4752, 4772, 4774, 4875, 4889, 4993, 5128, 5215, 5273, 5294], 'Physiol.': [579, 802, 849, 4994], '1996;': [580, 816, 850, 1696, 1762, 3769, 4500], '271:': [581, 851], 'C1781-C1799Crossref': [582, 852], 'Pretreatment': [586], 'preparations': [590], 'with': [591, 950, 1177, 1739, 1782, 1795, 1810, 1881, 1953, 1961, 2059, 2079, 2089, 2142, 2216, 2270, 2336, 2434, 2445, 2600, 2881, 2957, 2991, 3196, 3264, 3335, 3784, 3879, 3901, 4024, 4975, 5406], 'pertussis': [592, 600], 'toxin': [593], '(PTX)': [594], '1The': [595], 'abbreviations': [596], 'used': [597, 1455, 1496, 2064, 2184, 2402, 2548, 2923, 3998, 4919], 'are:': [598], 'PTX,': [599], 'toxin;': [601], 'PGE,': [602], 'E;': [604], 'QL,': [605], 'designating': [606], 'mutationally': [607, 3265], 'activated': [608, 1106, 1139, 3447, 3821], 'form': [609], 'Gα': [612, 699, 1382, 4945], 'subunit;': [613], 'HA,': [614], 'hemagglutinin;': [615], 'RGS,': [616], 'regulator': [617, 3988], 'signaling;': [621], 'GAP,': [622], 'GTPase-activating': [623], 'protein;': [624, 644], 'HBSS,': [625], 'Hepes-buffered': [626, 2275], 'saline': [627, 1876, 2276, 2534], 'solution;': [628], 'GSIS,': [629, 3912, 4238, 4307], 'secretion;': [632], 'GPCR,': [633], 'protein-coupled': [635], 'receptor;': [636], 'ERK,': [637], 'extracellular': [638], 'signal-related': [639], 'kinase;': [640], 'GFP,': [641], 'green': [642], 'fluorescent': [643], 'siRNA,': [645], 'RNA.': [648], 'alleviates': [649], 'effects': [652, 3857, 3871], 'hormones,': [657], 'leading': [658], 'original': [661], 'description': [662], 'PTX': [664, 684, 748, 827, 837, 2437, 3880, 3895, 3955, 4300, 4947], 'islet-activating': [666], '(3Katada': [668], 'T.': [669, 4009, 4073, 4134, 4138, 4376, 4879], 'Ui': [670], 'M.': [671, 708, 762, 959, 1309, 1687, 1753, 3017, 3042, 3605, 3658, 3722, 4128, 4372, 4506, 4641, 4786, 5162], 'Biol.': [673, 714, 967, 991, 1015, 1121, 1191, 1243, 1284, 1317, 1442, 1695, 1761, 3134, 3154, 3283, 3460, 3575, 3710, 3831, 4014, 4051, 4079, 4164, 4753, 5129, 5216, 5295], 'Chem.': [674, 968, 992, 1016, 1122, 1192, 1244, 1285, 1318, 1443, 3135, 3155, 3284, 3461, 3576, 3711, 3832, 4052, 4080, 4165, 4754, 5130, 5217, 5296], '1979;': [675], '254:': [676], '469-479Abstract': [677], 'catalyzes': [685], 'ADP-ribosylation': [687], 'cysteine': [690], 'residue': [691], 'near': [692], 'C': [694], 'terminus': [695], 'nearly': [697, 2225], 'all': [698, 2871, 3884], 'subunits': [700], 'subfamily': [704, 3210, 3453, 3887, 3941, 4360, 4850, 5159, 5242], '(4Moss': [705], 'Vaughan': [707], 'Adv.': [709], 'Enzymol.': [710], 'Relat.': [711], 'Areas': [712], '1988;': [715, 4386, 4409], '61:': [716], '303-379PubMed': [717], 'Scholar),': [719, 855, 2735, 2809, 4093, 4119, 4178, 4416, 4567, 4675, 5177, 5281, 5305], 'suggesting': [720, 2824, 3920, 3959, 4840], '(GSIS)': [728], 'mediated': [730], 'proteins.': [733], 'However,': [734, 4825, 5249], 'several': [735, 2932], 'reports': [736, 2690], 'indicate': [737, 3357, 3525], 'lack': [739], 'effect,': [741, 746], 'or': [742, 838, 1182, 1798, 2320, 2443, 2476, 2495, 2664, 2780, 3298, 3479, 3790, 3905, 4033, 4193, 4254, 4608, 4871], 'only': [743], 'partial': [745], 'pretreatment': [749, 3956], '(5Hillaire-Buys': [757, 3653], 'D.': [758, 3046, 3067, 3603, 3654, 4639, 4784], 'Gross': [759, 3655], 'Roye': [761, 3657], 'Ribes': [763, 3659], 'G.': [764, 902, 910, 2702, 2710, 2791, 2799, 3013, 3660, 4469, 4477], 'Loubatieres-Mariani': [765, 3661], 'M.M.': [766, 1918, 3662], 'Eur.': [767, 3663], 'Pharmacol.': [769, 1039, 1341, 3634, 3665, 3727, 4142], '1992;': [770, 789, 3666], '218:': [771, 3667, 4905], '359-362Crossref': [772, 3668], '(6)': [775, 3671], 'Scholar,': [777, 796, 810, 981, 1005, 1029, 1331, 2720, 3028, 3065, 3148, 3589, 3626, 3673, 3688, 3720, 4065, 4150, 4393, 4487, 4504, 4527, 4548, 4625, 4662, 4897, 5108, 5119], '6Seaquist': [778], 'E.R.': [779, 3233, 3376], 'Neal': [780], 'A.R.': [781], 'Shoger': [782], 'K.D.': [783, 3698], 'Walseth': [784, 3234, 3377], 'T.F.': [785, 3235, 3378], 'Robertson': [786, 5126, 5213], 'R.P.': [787, 3231, 3374, 5018, 5068, 5097, 5110, 5127, 5214], 'Diabetes.': [788, 3020, 3236, 3379, 5069, 5111], '41:': [790], '1390-1399Crossref': [791], '(39)': [794], '7Ribalet': [797], 'B.': [798, 906, 2706, 2795, 3277, 4473, 4497], 'Eddlestone': [799], 'G.T.': [800, 2724], '1995;': [803, 4541, 4562, 4890, 5170], '485:': [804], '73-86Crossref': [805], '(46)': [808], '8Sjoholm': [811], 'A.': [812, 904, 1011, 1280, 2704, 2793, 3057, 3088, 3597, 3618, 3690, 3765, 4047, 4069, 4111, 4385, 4408, 4471, 4491, 4519, 4550, 4556, 4633, 4654, 4778, 4799, 5166], 'Biochim.': [813, 3766, 5167], 'Biophys.': [814, 3767, 5168], 'Acta.': [815, 3768, 5169], '1313:': [817, 3770], '106-110Crossref': [818, 3771], '(23)': [821, 3640, 3774], 'This': [824, 4264, 4281, 4854], 'phenomenon': [825], 'insensitivity': [828, 4301], 'has': [829, 1212, 1401, 2950, 3555, 3644, 4601, 4686], 'been': [830, 1213, 3557, 4433, 4602], 'suggested': [831], 'because': [834, 3751], 'insufficient': [836], 'too': [839], 'short': [840], 'period': [842], 'exposure': [844], 'although': [856, 3922, 4596, 5250], 'alternative': [858], 'explanation': [859], 'certain': [862, 1457, 2489], 'GPCRs': [863, 3541], 'coupled': [865, 4346], 'PTX-insensitive': [868, 875, 3755, 4040, 4355], 'protein.': [870], 'The': [871, 1074, 1429, 1574, 1612, 2006, 2069, 2122, 2424, 2526, 2544, 2630, 3552, 4734, 4933], 'finding': [872, 4691], 'member': [878, 1064, 4356, 4729, 5243], '(9Fields': [880, 4441, 4612, 5268], 'T.A.': [881, 4442, 4613, 5269], 'Casey': [882, 988, 1012, 1036, 1118, 1188, 1240, 1281, 1338, 3131, 3151, 3457, 3572, 3828, 4048, 4161, 4443, 4614, 4750, 5270, 5361], 'P.J.': [883, 989, 1013, 1037, 1119, 1189, 1241, 1282, 1339, 1434, 3132, 3152, 3458, 3573, 3601, 3628, 3829, 4049, 4162, 4444, 4615, 4637, 4751, 4782, 5271, 5287], 'Biochem.': [884, 1920, 4445, 4540, 4616, 5272], '1997;': [886, 3683, 4112, 4447, 4618, 5274], '321:': [887, 4448, 4619, 5275], '561-571Crossref': [888, 4449, 4620, 5276], '(248)': [891, 4452, 4623, 5279], 'Scholar)': [893, 920, 1298, 1452, 1769, 1928, 3642, 3845, 4767, 4911], 'might': [894], 'expressed': [896, 1367, 2753, 2812, 2916, 3175, 3420, 4462, 5203], 'cells': [900, 1170, 1591, 1633, 1647, 1871, 2148, 2163, 2190, 2197, 2248, 2266, 2362, 2370, 2413, 2431, 2456, 2528, 2581, 2597, 2944, 2982, 3189, 3202, 3424, 3520, 3544, 3808, 3876, 3931, 3967, 4021, 4185, 4747, 4819, 4967], '(10Skoglund': [901, 2701, 2790, 4468], 'Basmaciogullari': [903, 2703, 2792, 4470], 'Rouot': [905, 2705, 2794, 4472], 'Marie': [907, 2707, 2796, 4474], 'J.C.': [908, 2708, 2797, 3030, 4475], 'Rosselin': [909, 2709, 2798, 4476], 'Endocrinol.': [912, 2712, 2801, 4479], '1999;': [913, 993, 1123, 2713, 2802, 3136, 4480, 5131, 5218], '162:': [914, 2714, 2803, 4481], '31-37Crossref': [915, 2715, 2732, 2804, 4482], '(18)': [918, 2718, 2807, 4485, 4909], 'opened': [921], 'possibility': [923], 'exists': [928, 5232], 'β-cells.': [930, 3407, 4594], 'Clues': [931], 'unique': [934, 1362, 3394, 4728, 5320], 'functions': [935], 'have': [938, 4432, 5033, 5326], 'emerged': [939], 'yeast': [941, 1266], 'two-hybrid': [942, 1267], 'screens': [943, 1268], 'identified': [945, 4368], 'proteins': [946, 1092, 3372, 4007, 4122, 4189, 4929, 5258, 5350], 'selectively': [948, 4000, 4037, 4968], 'interact': [949], 'constitutively': [951], 'active': [952, 3266], '(11Fan': [954, 1304], 'X.': [955, 1305], 'Brass': [956, 1306, 3610, 4646, 4791], 'L.F.': [957, 1307, 3611, 4647, 4792], 'Poncz': [958, 1308, 3604, 4640, 4785], 'Spitz': [960, 1310], 'F.': [961, 1311], 'Maire': [962, 1312], 'P.': [963, 987, 1117, 1313, 1692, 1758, 3071, 3130, 4399], 'Manning': [964, 1314, 3602, 4638, 4783], 'D.R.': [965, 1315], '2000;': [969, 1319, 3021, 3619, 4655, 4800], '275:': [970, 1320], '32129-32134Abstract': [971, 1321], '(52)': [979, 1329], '12Meng': [982], 'Glick': [984, 1032, 1114, 1334, 3127], 'J.L.': [985, 1007, 1033, 1115, 1276, 1335, 3128, 4043], 'Polakis': [986, 1116, 3129], '274:': [994, 1124, 3137, 5132, 5219], '36663-36669Abstract': [995, 1125, 3138], '(77)': [1003, 1133, 3146], '13Glick': [1006], 'Meigs': [1008, 1277, 4044], 'T.E.': [1009, 1278, 4045, 4152], 'Miron': [1010, 1279, 4046], '1998;': [1017, 1286, 4053, 4081, 5070, 5112], '273:': [1018, 1287, 4054, 4082], '26008-26013Abstract': [1019, 1288, 4055], '(115)': [1027, 1296, 4063], '14Embry': [1030, 1332], 'A.C.': [1031, 1333], 'Linder': [1034, 1336, 4099], 'M.E.': [1035, 1337, 4100], '2004;': [1040, 1342, 4015], '66:': [1041, 1343], '1325-1331Crossref': [1042, 1344], '(24)': [1045, 1347], 'One': [1048], 'best': [1051, 3116], 'characterized': [1052], 'effectors': [1054, 1259, 5311], 'Rap1GAP,': [1056, 3122, 3399, 5314], 'GTPase': [1058], 'activating': [1059], '(GAP)': [1061], 'Ras': [1067], 'proteins,': [1072, 3994], 'Rap1.': [1073], 'physical': [1075], 'interaction': [1076], 'between': [1077, 2176, 2623, 5188, 5253], 'Rap1GAP': [1080, 1145, 1225, 3173, 3434, 3510, 3801, 3812, 4816], 'ability': [1084, 1104, 3326, 3428, 4205, 4289, 4309], 'regulators': [1086], '(RGS)': [1091, 3993], 'stimulate': [1094], 'intrinsic': [1096], 'GTP': [1097], 'hydrolysis': [1098], 'activity': [1099, 1728], 'inhibit': [1109, 3219, 3363, 4001, 4038, 4209, 4293, 4712, 5003], 'adenylyl': [1110, 3364], 'cyclase': [1111, 3365], '(12Meng': [1112, 3125], 'In': [1136, 1350, 1374, 1891, 2488, 2838, 2979, 4576], 'cell-based': [1137], 'studies,': [1138], 'able': [1142], 'recruit': [1144], 'cytosol': [1148, 1894, 3437, 3493, 3513], 'plasma': [1151, 1228], 'membrane.': [1152], 'Through': [1153], 'process,': [1155], 'Rap1': [1160, 1235, 3124], 'accompanying': [1163], 'ERK': [1164], 'phosphorylation': [1165], 'differentiation': [1167], 'PC12': [1169, 4746], 'normally': [1173], 'induced': [1174], 'analogue': [1181], 'nerve': [1183], 'factor': [1185], '(15Meng': [1186, 1238, 3455, 3570, 4748], '277:': [1194, 1246, 3157, 3463, 3578, 3834, 4756], '43417-43424Abstract': [1195, 1247, 3158, 3464, 3579, 3835, 4757], '(48)': [1203, 1255, 3166, 3472, 3587, 3843, 4765], 'Based': [1206], 'findings,': [1209], 'model': [1211, 4745], 'proposed': [1214], 'results': [1221, 3524, 3850, 4572, 4934, 5325], 'recruitment': [1223], 'membrane,': [1229, 3440], 'where': [1230], 'it': [1231, 3934], 'effectively': [1233], 'down-regulate': [1234], 'Other': [1258], 'were': [1263, 1420, 1497, 1531, 1549, 1592, 1634, 1648, 1670, 1711, 1733, 1746, 1779, 1806, 1872, 1898, 1951, 2026, 2084, 2114, 2126, 2140, 2153, 2183, 2198, 2211, 2234, 2249, 2267, 2334, 2363, 2371, 2391, 2414, 2432, 2457, 2499, 2529, 2582, 2591, 2598, 2640, 2769, 3102, 3174, 3483, 3877, 3899, 4022, 4259], 'discovered': [1264], 'include': [1269], 'Gαz-selective': [1272], '(13Glick': [1275, 4042], 'transcriptional': [1301], 'cofactor': [1302], 'Eya2': [1303, 5317], 'study': [1353, 2764, 3855, 4694], 'demonstrated': [1355, 4434], 'axis': [1365, 3414, 3529], 'lines.': [1373], 'addition,': [1375], 'utilizing': [1376], 'three': [1377, 4940], 'separate': [1378, 2840], 'methods': [1379], 'perturb': [1381], 'signaling,': [1383, 4946], 'establish': [1385], 'required': [1389], 'PGE1-mediated': [1391, 4235], 'GSIS.': [1394, 3331], 'suggest': [1398], 'physiological': [1403, 4724, 4982, 5035], 'Materials—Anti-GFP,': [1411], 'Gα12,': [1412], 'Rap1,': [1413, 3401], 'myc-tag,': [1414], 'HA-tag,': [1415], 'primary': [1418, 1956], 'antibodies': [1419, 1805], 'obtained': [1421, 1532, 1580, 1619, 1994, 2115, 2931], 'Santa': [1423], 'Cruz': [1424, 1802], 'Biotechnology': [1425], '(Santa': [1426, 1801], 'Cruz,': [1427], 'CA).': [1428, 2137, 2525, 2651], 'anti-Gαz': [1430, 1799], 'antibody': [1431, 2878, 2888], 'P-961': [1432], '(16Casey': [1433, 5286], 'Fong': [1435, 4511, 5288], 'H.K.': [1436, 4395, 4512, 5289], 'Simon': [1437, 4400, 5290], 'M.I.': [1438, 3630, 4401, 5291], 'Gilman': [1439, 5292], 'A.G.': [1440, 5293], '1990;': [1444, 5297], '265:': [1445, 5298], '2383-2390Abstract': [1446, 5299], 'was': [1453, 1467, 1475, 1487, 1579, 1618, 1729, 1846, 1860, 1911, 1942, 1971, 1993, 2010, 2046, 2057, 2072, 2324, 2359, 2401, 2480, 2510, 2547, 2557, 2621, 2633, 2684, 2746, 2765, 2857, 2873, 2879, 2889, 2896, 3333, 3915, 3951, 4181, 4366, 4736], 'also': [1454, 5032, 5371, 5391], 'experiments,': [1458], 'indicated': [1460], 'respective': [1463, 2123], 'figure': [1464, 1517, 2452], 'legends.': [1465, 1518, 2453], 'Anti-Rap1GAP': [1466], 'gift': [1469, 1477, 1489], 'Paul': [1471], 'Polakis,': [1472], 'Genentech,': [1473], 'anti-pan-Gαi': [1474], 'Tom': [1479], 'Gettys,': [1480], 'Pennington': [1481], 'Biomedical': [1482], 'Research': [1483], 'Institute,': [1484], 'anti-RGSZ1': [1486], 'Elliot': [1491], 'Ross,': [1492], 'UT-Southwestern.': [1493], 'siRNA': [1494, 2605, 4248], 'oligonucleotides': [1495, 1509, 4249], 'control': [1499, 4256], 'luciferase': [1500, 4257], 'plasmid': [1501], 'sequence': [1502, 4258], '(Dharmacon,': [1503], 'Lafayette,': [1504], 'CO)': [1505], 'rat': [1507, 1521, 1613, 2696, 2904, 5205], 'Gαz-specific': [1508, 2883, 3118, 5310], '(Ambion,': [1510], 'Austin,': [1511], 'TX)': [1512], 'stated': [1514], 'Cell': [1519, 1622, 1694, 1760, 1987, 4539], 'Culture—The': [1520], 'insulinoma': [1522, 1576], 'Ins-1': [1524, 2943, 2988], 'selected': [1527, 2085, 2430], 'glucose-responsive': [1528], 'subline': [1530], 'Chistopher': [1534], 'Newgard': [1535, 3018, 3049, 3078, 5377, 5394], 'at': [1536, 1545, 1625, 1650, 1905, 2200], 'Sarah': [1538], 'W.': [1539], 'Stedman': [1540], 'Nutrition': [1541], 'Metabolism': [1543], 'Center': [1544, 2000], 'Duke': [1546, 1627], 'University.': [1547], 'Cells': [1548, 2210, 2233, 2590, 3475], 'maintained': [1550, 1593, 1635], 'RPMI': [1552], '1640': [1553], 'medium': [1554, 1598, 1640, 2045, 2056, 2071, 2509], 'containing': [1555, 1599, 1641, 1657], '10%': [1556, 1642, 1673], 'fetal': [1557, 1602, 1643], 'calf': [1558, 1603, 1644], 'serum,': [1559, 1604], '10': [1560, 1605], 'mm': [1561, 1564, 1567, 1606, 1774, 2273, 2280, 2283, 2286, 2289, 2295, 2311, 2318, 2322, 2338, 2461, 2474, 2478, 2571, 2576], 'Hepes,': [1562, 1607, 2291], 'glutamine,': [1565], '1': [1566, 2214, 2314, 2470], 'sodium': [1568], 'pyruvate,': [1569], '50': [1571, 1609], 'μm': [1572, 1610], 'β-mercaptoethanol.': [1573, 1611], 'mouse': [1575], 'line,': [1577], 'Min6,': [1578, 2936], 'Dr.': [1582], 'Miyazaki': [1584], '(University': [1585, 2001], 'Tokyo,': [1587, 1588], 'Japan).': [1589], 'Min6': [1590, 2941], "Dulbecco's": [1595, 1637], 'modified': [1596, 1638], "Eagle's": [1597, 1639], '15%': [1600], 'heat-inactivated': [1601], 'exocrine': [1615, 3186], 'Panc-1': [1617, 1632, 3188], 'Culture': [1623, 2166], 'Facility': [1624], 'University': [1628], 'Comprehensive': [1629], 'Cancer': [1630], 'Center.': [1631], 'serum.': [1645], 'All': [1646, 2332], 'kept': [1649], '37': [1651], '°C': [1652], 'humidified': [1655], 'atmosphere': [1656], '95%': [1658], 'air': [1659], '5%': [1661, 1741], 'CO2': [1662], 'passaged': [1664], 'after': [1665, 2052, 2074, 4275], 'reaching': [1666], '80–90%': [1667], 'confluence.': [1668], 'Immunohistochemistry—Tissues': [1669], 'fixed': [1671], 'neutral': [1674], 'buffered': [1675], 'formalin': [1676], 'then': [1678, 1734, 1794, 2303, 3496], 'processed': [1679], 'into': [1680, 2012, 2028, 2128, 2146, 2160, 4261], 'paraffin': [1681], 'using': [1683, 1849, 1973, 2036, 2170, 2607, 2642], 'standard': [1684], 'protocols': [1685], '(17Werner': [1686, 1752], 'Von': [1688, 1754], 'Wasielewski': [1689, 1755], 'Komminoth': [1691, 1757], 'Histochem.': [1693, 1759], '105:': [1697, 1763], '253-260Crossref': [1698, 1764], '(143)': [1701, 1767], 'Briefly,': [1704], '5-μm': [1705], 'sections': [1706, 1732], 'formalin-fixed,': [1708], 'paraffin-embedded': [1709], 'placed': [1712], 'positively': [1714], 'charged': [1715], 'slides': [1716], 'permitted': [1718], 'dry,': [1720], 'followed': [1721, 1736, 1819, 1862, 1958, 2669], 'removal': [1723], 'paraffin.': [1725], 'Endogenous': [1726], 'peroxidase': [1727, 1852, 1965, 1970], 'quenched,': [1730], 'hydrated,': [1735], 'incubation': [1738, 1809, 1960], 'goat': [1742, 1812], 'serum': [1743, 2300], 'solution.': [1744, 1890], 'Sections': [1745, 1778], 'subjected': [1747, 3486], 'heat-induced': [1749], 'epitope': [1750], 'retrieval': [1751], 'steaming': [1771], '100': [1773, 2435], 'glycine,': [1775], 'pH': [1776, 2292], '3.0.': [1777], 'next': [1780, 2909, 3323, 3537], 'incubated': [1781, 1952], 'Background': [1783], 'Buster®': [1784], '(Innovex': [1785], 'Biosciences,': [1786, 2439], 'Richmond,': [1787], 'CA)': [1788, 1818, 1828, 2442], 'reduce': [1790], 'background': [1791], 'staining': [1792, 2872], 'anti-glucagon,': [1796], 'anti-insulin,': [1797], 'antisera': [1800, 1814], 'Biotechnology).': [1803], 'Bound': [1804], 'detected': [1807, 1972, 2859, 2898], 'biotinylated': [1811], 'anti-rabbit': [1813], '(Vector': [1815, 1825], 'Laboratories,': [1816, 1826], 'Burlingame,': [1817, 1827], 'RTU': [1821], 'Vectastain': [1822], 'ABC': [1823], 'reagent': [1824, 1977, 2378], 'finally': [1830], 'horseradish': [1832, 1851], 'peroxidase-labeled': [1833], 'streptavidin': [1834], '(Jackson': [1835], 'ImmunoResearch,': [1836], 'West': [1837], 'Grove': [1838], 'Park,': [1839], 'PA).': [1840], 'Visualization': [1841], 'bound': [1843], 'immune': [1844], 'complex': [1845], 'performed': [1847, 2392, 2634, 3900], 'substrate.': [1853], 'Hematoxylin': [1854], 'counterstain': [1855], '(Fisher': [1856], 'Scientific,': [1857], 'Pittsburgh,': [1858], 'PA)': [1859], 'used,': [1861], 'traditional': [1864], 'dehydration,': [1865], 'clearing,': [1866], 'mounting.': [1868], 'Immunoblot': [1869], 'Analysis—Adherent': [1870], 'washed': [1873, 2268, 2364, 2530], 'phosphate-buffered': [1875, 2367, 2533], 'lysed': [1878, 2372, 2536], 'scraping': [1880, 2538], 'rubber': [1883], 'policeman': [1884], 'sonicating': [1886, 2540], 'Tris-EDTA': [1889, 2542], 'cases,': [1893], 'membrane': [1896, 3491, 3516, 3804], 'fractions': [1897, 3494], 'separated': [1899, 1943], 'ultracentrifugation': [1901, 3488], '5': [1903, 2060, 2594], 'min': [1904, 2342], '200,000': [1906], '×': [1907, 2202, 2595], 'g.': [1908], 'Protein': [1909, 1930, 2399], 'content': [1910, 2400, 2516, 3106], 'determined': [1912, 2229], 'Bradford': [1915], 'method': [1916], '(18Bradford': [1917], 'Anal.': [1919], '1976;': [1921], '72:': [1922], '248-254Crossref': [1923], '(217544)': [1926], '(Bio-Rad': [1929], 'Assay,': [1931], 'Bio-Rad).': [1932], 'Unless': [1933], 'otherwise': [1934], 'indicated,': [1935], '40': [1936], 'μg': [1937], 'total': [1939], 'SDS-PAGE': [1945], 'transferred': [1947], 'nitrocellulose.': [1949], 'Membranes': [1950], 'appropriate': [1955], 'antibody,': [1957], 'anti-rabbitor': [1963], 'anti-mouse-horseradish': [1964], 'conjugate': [1966], '(Amersham': [1967], 'Biosciences).': [1968, 2384], 'Horseradish': [1969], 'Western': [1974], 'Lightning®': [1975], 'chemiluminescence': [1976], '(PerkinElmer).': [1978], 'Generation': [1979, 2096], 'Recombinant': [1981, 2098, 2150], 'Retroviruses': [1982], 'Selection': [1984], 'Stable': [1986, 2082], 'Lines—The': [1988], 'cDNA': [1989, 1998, 2119], 'encoding': [1990, 2105, 4026], 'wild-type': [1991, 3782, 4821], 'UMR': [1997, 2118], 'Resource': [1999], 'Missouri,': [2003], 'Rolla,': [2004], 'MO).': [2005], 'coding': [2008, 2124], 'region': [2009], 'subcloned': [2011, 2127], 'EcoRI-NotI': [2014], 'sites': [2015], 'retroviral': [2018], 'shuttle': [2019, 2131], 'vector': [2020, 2132], 'pLPCX': [2021], '(Clontech).': [2022], 'pLPCX-Gαz': [2023], 'pVSV-G': [2025], 'cotransfected': [2027], 'pantropic': [2030], 'packaging': [2031], 'cell': [2032, 2989, 3100, 3568, 5062], 'GP2': [2034], '293': [2035, 2162, 2189], 'cesium': [2037], 'chloride': [2038], 'precipitation': [2039], 'according': [2040, 2395], "manufacturer's": [2042, 2397], 'protocol.': [2043, 2398], 'Viral': [2044, 2173], 'filtered': [2047], 'concentrated': [2049], '48': [2050, 2635, 4276], 'h': [2051, 2076, 2087, 2215, 2243, 2307, 2636, 4277], 'transfection.': [2053], 'Concentrated': [2054], 'viral': [2055, 2181, 2194], 'mixed': [2058], 'μg/ml': [2061, 2091], 'Polybrene': [2062], 'infect': [2066, 2187], 'cells.': [2068, 4263], 'infection': [2070, 2227], 'removed': [2073, 2511], '24': [2075, 2086, 2242], 'replaced': [2078], 'medium.': [2081], 'transformants': [2083], 'later': [2088], 'puromycin': [2092], '14': [2094], 'days.': [2095], 'Adenoviruses': [2099], 'Infection': [2101], 'Cells—cDNAs': [2104], 'Gαz(QL),': [2106], 'Gαi2(QL),': [2107], 'Gα12(QL),': [2108], 'RGS2,': [2109, 4032], 'p115': [2110, 4034], 'RhoGAP,': [2111], 'RGSZ1': [2113, 4202, 4315], 'resource': [2120], 'center.': [2121], 'regions': [2125], 'adenoviral': [2130, 2151], 'pAdTrack-CMV': [2133, 2138], '(Stratagene,': [2134], 'La': [2135], 'Jolla,': [2136], 'constructs': [2139], 'linearized': [2141], 'PmeI': [2143], 'electroporated': [2145, 2599], 'BJ5183-AD-1': [2147], '(Stratagene).': [2149], 'plasmids': [2152], 'purified': [2154], 'isolated': [2156, 2903, 3181, 4869], 'colonies': [2157], 'transfected': [2159], 'HEK': [2161, 2188], '(American': [2164], 'Collection,': [2167], 'Manassas,': [2168], 'VA)': [2169], 'Lipofectamine': [2171], '(Invitrogen).': [2172], 'plaques': [2174], 'formed': [2175], '7–10': [2177], 'days': [2178], 'posttransfection,': [2179], 'lysates': [2182], 'serially': [2186], 'large': [2192], 'scale': [2193], 'preparations.': [2195], 'plated': [2199], '2.5–3': [2201], '105': [2203], 'cells/well': [2204], '12-well': [2206, 2255, 2420, 2628], 'culture': [2208, 2257, 2422], 'plates.': [2209, 2258, 2423], 'infected': [2212, 2444, 3263, 4023], 'empirical': [2218], 'titer': [2219], 'virus': [2221], 'resulted': [2223, 3797, 4266], '100%': [2226, 2252, 2417], 'GFP': [2231], 'assayed': [2235, 2513], 'generation': [2238], 'postinfection.': [2244], 'Cyclic': [2245], 'AMP': [2246], 'Immunoassay—Ins-1(832/13)': [2247], 'grown': [2250, 2415, 2583], 'confluence': [2253, 2418, 2586], 'On': [2259], 'day': [2261, 2425], 'assay': [2264, 2407, 2553, 2632], 'once': [2269, 2365, 2531], '3': [2272, 2310, 2317, 2460, 2473, 2575], 'glucose-containing': [2274], 'solution': [2277, 2615], '(HBSS)': [2278], '(114': [2279], 'NaCl,': [2281], '4.7': [2282], 'KCl,': [2284], '1.2': [2285], 'KH2PO4,': [2287], '1.16': [2288], 'MgSO4,20mm': [2290], '7.2,': [2293], '25.5': [2294], 'NaHCO3,10mm': [2296], 'CaCl2,': [2297], '0.2%': [2298], 'bovine': [2299], 'albumin)': [2301], 'preincubated': [2304, 2458, 2880], 'fresh': [2309], 'glucose-HBSS.': [2312], 'Next,': [2313, 2469], 'ml': [2315, 2471], 'glucose-': [2319, 2475], '15': [2321, 2477, 2570], 'glucose-HBSS': [2323, 2462, 2479], 'added': [2325, 2481, 2500], 'each': [2327, 2389, 2483, 2949, 3099], 'well': [2328, 2484], 'h.': [2331, 2487], 'wells': [2333, 2625], 'treated': [2335, 2433, 3878], '0.2': [2337], 'isobutylmethylxanthine': [2339], '20': [2341], 'prior': [2343], 'during': [2346, 2501], 'stimulation': [2348, 2355, 2503, 4810], 'period.': [2349, 2504], 'At': [2350], 'end': [2352], 'time,': [2356], 'HBSS': [2358], 'removed,': [2360], 'saline,': [2368], '300': [2374], 'μl': [2375], 'lysis': [2377], '(cAMP': [2379], 'Biotrack®': [2380], 'Enzymeimmunoassay': [2381], 'System,': [2382], 'Amersham': [2383], 'Determinations': [2385], 'sample': [2390], 'duplicate': [2394], 'normalize': [2404, 2550], 'results.': [2408, 2554], 'Insulin': [2410, 2555], 'Secretion': [2411], 'Assays—Ins-1(832/13)': [2412], 'before': [2426], 'GSIS': [2428, 2631, 2954, 2993, 3344, 3652, 3897, 3948, 4180, 4210, 4294, 4322, 4713, 4829, 4863, 4985], 'assay,': [2429], 'ng/ml': [2436], '(EMD': [2438, 2497], 'San': [2440, 2649], 'Diego,': [2441, 2650], 'recombinant': [2446], 'adenoviruses': [2447, 4025], 'noted': [2449, 3389], 'Confluent': [2454], 'described': [2464, 3117, 4935, 5331], 'above': [2465], 'assays.': [2468], 'cases': [2490], 'GPCR': [2491, 3216, 3860], 'agonists': [2492, 4867], 'UK14,304': [2493, 3789, 3904, 3909, 4834], '(Sigma-Aldrich)': [2494], 'Biosciences)': [2498], 'Following': [2505, 3894], 'stimulation,': [2506, 2561], '(Coat-A-Count®': [2517], '[125I]insulin': [2518], 'radioimmunoassay,': [2519], 'Diagnostic': [2520], 'Products': [2521], 'Corp.,': [2522], 'Los': [2523], 'Angeles,': [2524], 'remaining': [2527], 'buffer.': [2543], 'concentration': [2546], 'represented': [2558], 'fold': [2560], 'ratio': [2565], 'glucose.': [2577], 'siRNA-mediated': [2578, 4952], 'Gene': [2579], 'Silencing—Ins-1(832/13)': [2580], '50–75%': [2585], '10-cm': [2588], 'dishes.': [2589], 'trypsinized,': [2592], '106': [2596], '200': [2601], 'pmol': [2602], 'annealed': [2604], 'oligonucleotide': [2606], 'Amaxa': [2609], 'Nucleofector®': [2610], '(Amaxa': [2611], 'Inc.,': [2612, 2648], 'Gaithersburg,': [2613], 'MD),': [2614], 'T,': [2616], 'program': [2617], 'T20.': [2618], 'Each': [2619], 'reaction': [2620], 'split': [2622], '4': [2624], 'plate.': [2629], 'postelectroporation.': [2637], 'Statistical': [2638], 'Analyses—Data': [2639], 'analyzed': [2641, 3108], 'GraphPad': [2643], 'Prism': [2644], 'v4': [2645], '(GraphPad': [2646], 'Software': [2647], 'Data': [2652], 'given': [2654], 'mean': [2657], '±': [2658], 'S.E.': [2659], 'compared': [2661, 2956], 'one-': [2663], 'two-way': [2665], 'analysis': [2666, 2901], 'variance,': [2668], 'relevant': [2672, 3865], 'post-test': [2673], 'determine': [2675], 'p': [2676, 2681], 'values.': [2677], 'A': [2678], 'probability': [2679], '<': [2682], '0.05': [2683], 'considered': [2685], 'significant.': [2686], 'There': [2687, 4455, 5231], 'two': [2689], 'Langerhans': [2700], '19Zigman': [2721], 'J.M.': [2722], 'Westermark': [2723], 'LaMendola': [2725], 'Steiner': [2727], 'D.F.': [2728], 'Endocrinology.': [2729, 4561], '1994;': [2730], '135:': [2731], 'but': [2736, 2870, 3183, 3502, 3823, 4568], 'neither': [2737], 'specificity': [2739, 2848], 'nor': [2740], 'relevance': [2742], 'determined.': [2747], 'To': [2748, 3245, 3408, 3867, 3972, 4228], 'confirm': [2749, 2912, 4229], 'delineate': [2758], 'pattern,': [2761], 'immunohistochemical': [2763, 2841], 'undertaken.': [2766], 'Mouse': [2767], 'pancreases': [2768], 'formalin-fixed': [2770], 'immunostained': [2772], 'glucagon': [2775], '(to': [2776, 2782], 'α-cells),': [2779], 'β-cells).': [2785], 'Confirming': [2786], 'previous': [2788], 'report': [2789], 'periphery': [2816, 2862], 'interior': [2818, 2864], '(Fig.': [2822, 2833, 2868, 2891, 2906, 3190, 3300, 3320, 3353, 3481, 3521, 3809, 3918, 3932, 3957, 4211, 4278, 4295, 4823, 4852], '1A),': [2823], 'α-cells': [2829], 'respectively': [2832], '1,': [2834], 'B': [2835], 'C).': [2837], 'experiment,': [2842], 'sought': [2844, 2910], 'demonstrate': [2846, 4333], 'islets.': [2853], 'Again,': [2854], 'readily': [2858, 2897], '1D),': [2869], 'lost': [2874], 'when': [2875, 4920], 'peptide': [2884], 'raised': [2890], '1E).': [2892], 'immunoblot': [2900], '1F).': [2907, 3191], 'We': [2908, 2930, 3322, 3536, 5355, 5370, 5390], 'lines': [2919, 3178, 4873], 'often': [2922], 'assess': [2925, 3246, 3410], 'vitro.': [2929], 'lines,': [2934, 2948], 'Ins-1,': [2937], 'Ins-1(832/13).': [2939], 'Although': [2940, 3908], 'established': [2946], 'fairly': [2952], 'low': [2953], '(20Ulrich': [2960], 'A.B.': [2961], 'Schmied': [2962], 'B.M.': [2963], 'Standop': [2964], 'Schneider': [2966], 'M.B.': [2967], 'Pour': [2968], 'P.M.': [2969], 'Pancreas.': [2970], '24:': [2972], '111-120Crossref': [2973], '(47)': [2976], 'contrast,': [2980], 'derivative': [2985], 'robust': [2992], 'magnitude': [2996], 'similar': [2997, 3368], 'normal': [3001, 5051], '(7–10-fold': [3003], 'responses': [3004], 'stimulatory': [3006], 'glucose)': [3007], '(21Hohmeier': [3008], 'H.E.': [3009], 'Mulder': [3010, 3068], 'H.': [3011, 3069, 3706, 4140, 4374, 4987], 'Chen': [3012], 'Henkel-Rieger': [3014], 'Prentki': [3016], 'C.B.': [3019, 3050, 3079, 4887], '49:': [3022], '424-430Crossref': [3023], '(717)': [3026], '22Schisler': [3029], 'Jensen': [3031, 3074], 'P.B.': [3032], 'Taylor': [3033], 'D.G.': [3034], 'Becker': [3035], 'T.C.': [3036], 'Knop': [3037], 'F.K.': [3038], 'Takekawa': [3039], 'S.': [3040, 3056, 3077, 3087, 3617, 3694, 4110, 4130, 4132, 4384, 4407, 4508, 4518, 4533, 4653, 4798, 4901], 'German': [3041], 'Weir': [3043], 'G.C.': [3044], 'Lu': [3045], 'Mirmira': [3047], 'R.G.': [3048], 'Proc.': [3051, 3082, 3612, 4105, 4379, 4402, 4513, 4648, 4793], 'Natl.': [3052, 3083, 3613, 4106, 4380, 4403, 4514, 4649, 4794], 'Acad.': [3053, 3084, 3614, 4107, 4381, 4404, 4515, 4650, 4795], 'Sci.': [3054, 3085, 3615, 4108, 4382, 4405, 4516, 4651, 4796], 'U.': [3055, 3086, 3616, 4109, 4383, 4406, 4517, 4652, 4797, 4885], '2005;': [3058, 4166], '102:': [3059], '7297-7302Crossref': [3060], '(131)': [3063], '23Lu': [3066], 'Zhao': [3070], 'Burgess': [3072], 'S.C.': [3073], 'M.V.': [3075], 'Kamzolova': [3076], 'Sherry': [3080], 'A.D.': [3081], '99:': [3090], '2708-2713Crossref': [3091], '(221)': [3094], 'Lysates': [3097], 'type': [3101], 'normalized': [3103], 'immunoblotting': [3110], 'pathway:': [3120], '15Meng': [3149], 'Interestingly,': [3169], 'findings': [3193, 3356], 'consistent': [3195], 'specific': [3197, 3445, 4002], 'islet.': [3206], 'Activation': [3207], 'Gi': [3209, 4732, 4849], 'number': [3214], 'ligands': [3217], 'various': [3220], 'functions,': [3222], '(24Robertson': [3230, 3373], 'Seaquist': [3232, 3375], '1991;': [3237, 3380, 3712, 4520], '40:': [3238, 3381], '1-6Crossref': [3239, 3382], '(80)': [3242, 3385], 'processes,': [3254], 'measured': [3257, 4182], '(QL': [3267], '(25Masters': [3268], 'S.B.': [3269], 'Miller': [3270], 'R.T.': [3271], 'Chi': [3272], 'M.H.': [3273], 'Chang': [3274], 'F.H.': [3275], 'Beiderman': [3276], 'Lopez': [3278], 'N.G.': [3279], 'Bourne': [3280], 'H.R.': [3281], '1989;': [3285], '264:': [3286], '15467-15474Abstract': [3287], 'Scholar))': [3293], 'forms': [3294], 'Gαi2,': [3297], 'Gα12': [3299], '2A).': [3301], 'Expression': [3302], 'Gαz(QL)': [3304, 3339, 3421, 3478, 3501], 'Gαi2(QL)': [3306, 3341, 3480, 3504], 'significantly': [3307, 3342, 3916, 4286], 'inhibited': [3308, 3343, 3911], 'production,': [3310, 3337], 'whereas,': [3311], 'expected,': [3313], 'Gα12(QL)': [3316, 3349], 'had': [3317, 3350], 'no': [3318, 3351], '2B).': [3321], 'assessed': [3324, 3538], 'impact': [3330], 'seen': [3334], 'whereas': [3348, 5153], '2C).': [3354], 'above,': [3390], 'axis,': [3397], 'initially': [3409], 'whether': [3411, 3539], 'functional': [3416, 4464, 4591], 'tested': [3426], 'cause': [3430], 'translocation': [3432, 3508, 3813], 'expressing': [3476, 3781, 4186, 4820], '3A)': [3482], 'disrupted': [3484], 'obtain': [3490], 'immunoblotted': [3497], 'Rap1GAP.': [3499], 'Importantly,': [3500], 'caused': [3505], 'significant': [3507], 'fraction': [3517, 3805], '3B).': [3522, 4824], 'Gαz-Rap1GAP': [3528], 'In-1(832/13)': [3543], 'could': [3545], 'fact': [3547], 'transmit': [3548], 'signals': [3549, 3968, 3980], 'Gz.': [3551, 3971, 4352, 4971, 5192], 'α2A-adrenergic': [3553], 'already': [3556], 'shown': [3558, 4738], 'capable': [3561], 'types': [3569], '26Yang': [3590, 4626], 'Wu': [3592, 4628, 4773], 'Kowalska': [3594, 4630, 4775], 'M.A.': [3595, 4631, 4776], 'Dalvi': [3596, 4632, 4777], 'Prevost': [3598, 4634, 4779], 'N.': [3599, 4098, 4635, 4780], "O'Brien": [3600, 4636, 4781], 'Lucki': [3606, 4642, 4787], 'I.': [3607, 4643, 4788, 4877], 'Blendy': [3608, 4644, 4789], 'J.A.': [3609, 4645, 4790], '97:': [3620, 4656, 4801], '9984-9989Crossref': [3621, 4657, 4802], '(171)': [3624, 4660, 4805], '27Kammermeier': [3627], 'Davis': [3629], 'Ikeda': [3631], 'S.R.': [3632], '2003;': [3635, 4143, 4995], '63:': [3636, 4144], '183-191Crossref': [3637], 'clear': [3646], '28Rodriguez-Pena': [3674], 'M.S.': [3675, 4552], 'Collins': [3676], 'Woodard': [3678], 'C.': [3679, 4493, 4883], 'Spiegel': [3680, 4559], 'A.M.': [3681, 4560], 'Endocrine.': [3682], '7:': [3684], '255-260Crossref': [3685], '29Schmidt': [3689], 'Hescheler': [3691], 'Offermanns': [3693], 'Spicher': [3695], 'K.': [3696, 4124], 'Hinsch': [3697], 'Klinz': [3699], 'F.J.': 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