Publication Information

{'id': 'https://openalex.org/W2083552214', 'doi': 'https://doi.org/10.1074/jbc.m413882200', 'title': 'Catalysis of Creatine Kinase Refolding by Protein Disulfide Isomerase Involves Disulfide Cross-link and Dimer to Tetramer Switch', 'display_name': 'Catalysis of Creatine Kinase Refolding by Protein Disulfide Isomerase Involves Disulfide Cross-link and Dimer to Tetramer Switch', 'publication_year': 2005, 'publication_date': '2005-02-06', 'ids': {'openalex': 'https://openalex.org/W2083552214', 'doi': 'https://doi.org/10.1074/jbc.m413882200', 'mag': '2083552214', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15695804'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m413882200', 'pdf_url': 'http://www.jbc.org/article/S0021925819604163/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819604163/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063433481', 'display_name': 'Tong‐Jin Zhao', 'orcid': 'https://orcid.org/0000-0001-6861-3071'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tong-Jin Zhao', 'raw_affiliation_strings': ['Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000944288', 'display_name': 'Wen‐Bin Ou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen-Bin Ou', 'raw_affiliation_strings': ['Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047569785', 'display_name': 'Qiang Xie', 'orcid': 'https://orcid.org/0000-0003-3652-604X'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiang Xie', 'raw_affiliation_strings': ['Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100355996', 'display_name': 'Yang Liu', 'orcid': 'https://orcid.org/0000-0002-8195-7706'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Liu', 'raw_affiliation_strings': ['Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028904289', 'display_name': 'Yong‐Bin Yan', 'orcid': 'https://orcid.org/0000-0002-8565-3558'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yong-Bin Yan', 'raw_affiliation_strings': ['Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China', 'State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}, {'raw_affiliation_string': 'State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110278155', 'display_name': 'Hai‐Meng Zhou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Hai-Meng Zhou', 'raw_affiliation_strings': ['Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5028904289', 'https://openalex.org/A5110278155'], 'corresponding_institution_ids': ['https://openalex.org/I99065089', 'https://openalex.org/I99065089'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.652, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.737318, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '280', 'issue': '14', 'first_page': '13470', 'last_page': '13476'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10934', 'display_name': 'Heat shock proteins research', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tetramer', 'display_name': 'Tetramer', 'score': 0.9267438}, {'id': 'https://openalex.org/keywords/cross-link', 'display_name': 'Cross-link', 'score': 0.46360362}, {'id': 'https://openalex.org/keywords/link', 'display_name': 'Link (geometry)', 'score': 0.43920514}], 'concepts': [{'id': 'https://openalex.org/C2778886173', 'wikidata': 'https://www.wikidata.org/wiki/Q53832', 'display_name': 'Tetramer', 'level': 3, 'score': 0.9267438}, {'id': 'https://openalex.org/C5098756', 'wikidata': 'https://www.wikidata.org/wiki/Q1641611', 'display_name': 'Protein disulfide-isomerase', 'level': 3, 'score': 0.8887192}, {'id': 'https://openalex.org/C27256138', 'wikidata': 'https://www.wikidata.org/wiki/Q1230226', 'display_name': 'Disulfide bond', 'level': 2, 'score': 0.78699714}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.7239297}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6248054}, {'id': 'https://openalex.org/C2781264208', 'wikidata': 'https://www.wikidata.org/wiki/Q118026', 'display_name': 'Isomerase', 'level': 3, 'score': 0.4992714}, {'id': 'https://openalex.org/C142708767', 'wikidata': 'https://www.wikidata.org/wiki/Q898597', 'display_name': 'Cross-link', 'level': 3, 'score': 0.46360362}, {'id': 'https://openalex.org/C2778753846', 'wikidata': 'https://www.wikidata.org/wiki/Q6554239', 'display_name': 'Link (geometry)', 'level': 2, 'score': 0.43920514}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40187645}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2611099}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.09741229}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.09491649}, {'id': 'https://openalex.org/C521977710', 'wikidata': 'https://www.wikidata.org/wiki/Q81163', 'display_name': 'Polymer', 'level': 2, 'score': 0.06477341}, {'id': 'https://openalex.org/C31258907', 'wikidata': 'https://www.wikidata.org/wiki/Q1301371', 'display_name': 'Computer network', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003402', 'descriptor_name': 'Creatine Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003402', 'descriptor_name': 'Creatine Kinase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D019704', 'descriptor_name': 'Protein Disulfide-Isomerases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020673', 'descriptor_name': 'Protein Renaturation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020836', 'descriptor_name': 'Protein Structure, Quaternary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003402', 'descriptor_name': 'Creatine Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019791', 'descriptor_name': 'Guanidine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D019791', 'descriptor_name': 'Guanidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008962', 'descriptor_name': 'Models, Theoretical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011489', 'descriptor_name': 'Protein Denaturation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019704', 'descriptor_name': 'Protein Disulfide-Isomerases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m413882200', 'pdf_url': 'http://www.jbc.org/article/S0021925819604163/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15695804', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m413882200', 'pdf_url': 'http://www.jbc.org/article/S0021925819604163/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.43, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1501582165', 'https://openalex.org/W1542277858', 'https://openalex.org/W1551340508', 'https://openalex.org/W1559988816', 'https://openalex.org/W1964623405', 'https://openalex.org/W1969721783', 'https://openalex.org/W1971068216', 'https://openalex.org/W1971697017', 'https://openalex.org/W1991428531', 'https://openalex.org/W2004103247', 'https://openalex.org/W2005145242', 'https://openalex.org/W2009650953', 'https://openalex.org/W2010874844', 'https://openalex.org/W2015898854', 'https://openalex.org/W2034811695', 'https://openalex.org/W2036503551', 'https://openalex.org/W2037147486', 'https://openalex.org/W2038125665', 'https://openalex.org/W2038909360', 'https://openalex.org/W2041250116', 'https://openalex.org/W2054397720', 'https://openalex.org/W2067891930', 'https://openalex.org/W2069546835', 'https://openalex.org/W2071197084', 'https://openalex.org/W2072348582', 'https://openalex.org/W2088982422', 'https://openalex.org/W2091082518', 'https://openalex.org/W2110324701', 'https://openalex.org/W2110502225', 'https://openalex.org/W2119193212', 'https://openalex.org/W2130230410', 'https://openalex.org/W2132489088', 'https://openalex.org/W2161842478', 'https://openalex.org/W2222366583', 'https://openalex.org/W2931349', 'https://openalex.org/W4234395860'], 'related_works': ['https://openalex.org/W4239258835', 'https://openalex.org/W3185489799', 'https://openalex.org/W2509147843', 'https://openalex.org/W2120426137', 'https://openalex.org/W2118307557', 'https://openalex.org/W2087593066', 'https://openalex.org/W2083552214', 'https://openalex.org/W1980452076', 'https://openalex.org/W184948381', 'https://openalex.org/W1010202294'], 'abstract_inverted_index': {'Protein': [0, 235, 1243, 1536, 4536], 'disulfide': [1, 74, 117, 236, 309, 352, 503, 537, 542, 551, 969, 1194, 1998, 2458, 2814, 2850, 2933, 3534, 3589, 3910, 4042, 4131, 4170, 4227, 4477, 4588, 5277, 5334, 5368, 5899, 6021, 6061, 6085], 'isomerase': [2, 7, 237, 242, 543, 737, 3945, 4220, 4293, 4361, 5987], '(PDI)': [3, 238], 'functions': [4, 199, 239, 434, 5622, 6003], 'as': [5, 12, 20, 83, 107, 200, 240, 247, 255, 318, 342, 435, 882, 1295, 1364, 1574, 1711, 1723, 1813, 2014, 2024, 3436, 3684, 3938, 4094, 4101, 4120, 4286, 4500, 4753, 5132, 5513, 5965, 6117, 6119, 6136, 6138], 'an': [6, 89, 241, 324, 929, 1226, 1351, 1777, 1814, 1925, 2162, 2902, 3332, 3411, 3437, 3532, 4102, 4851, 4896, 5212, 5292, 5354, 5911, 5977], 'to': [8, 15, 55, 59, 109, 195, 204, 243, 250, 290, 294, 344, 430, 439, 484, 893, 934, 1004, 1077, 1139, 1409, 1425, 1444, 1459, 1544, 1685, 1697, 1699, 1702, 1729, 1890, 1917, 1989, 1995, 2208, 2238, 2255, 2277, 2321, 2331, 2386, 2451, 2471, 2496, 2615, 2678, 2838, 2926, 2950, 3124, 3183, 3209, 3219, 3234, 3249, 3263, 3317, 3331, 3335, 3407, 3502, 3727, 3756, 3785, 3811, 3889, 3917, 3936, 4123, 4199, 4217, 4355, 4358, 4392, 4421, 4494, 4554, 4574, 4578, 4601, 4700, 4739, 4746, 4751, 4807, 4879, 4894, 4907, 4923, 4966, 5002, 5073, 5184, 5208, 5231, 5251, 5262, 5312, 5337, 5418, 5615, 5626, 5727, 5782, 5791, 5805, 5954, 5963, 6032, 6088, 6099], 'catalyze': [9, 244], 'thiol:disulfide': [10, 245], 'exchange,': [11, 246], 'a': [13, 21, 31, 84, 119, 201, 220, 248, 256, 266, 319, 354, 436, 455, 498, 629, 645, 653, 727, 731, 785, 867, 877, 938, 955, 1011, 1033, 1152, 1200, 1303, 1436, 1451, 1476, 1746, 1758, 1763, 1766, 1781, 1825, 1847, 1918, 1966, 1990, 2079, 2109, 2120, 2256, 2311, 2391, 2483, 2657, 2889, 2906, 2928, 3073, 3084, 3163, 3503, 3673, 3685, 3719, 3734, 3804, 3828, 3939, 4095, 4288, 4565, 4608, 4693, 4702, 4715, 4754, 4765, 4769, 4808, 4979, 5055, 5289, 5361, 5397, 5507, 5611, 5700, 5749, 5778, 5798, 5810, 5833, 5842, 5883, 5944, 5948, 5966, 6037], 'chaperone': [14, 249, 3686, 3941, 4201, 4755, 5974], 'assist': [16, 251, 3742], 'protein': [17, 252, 541, 550, 782, 965, 1229, 1297, 5455], 'folding,': [18, 253], 'and': [19, 25, 48, 65, 67, 123, 133, 137, 153, 174, 210, 254, 260, 283, 300, 302, 358, 368, 372, 388, 409, 445, 477, 482, 525, 533, 631, 642, 650, 652, 728, 886, 943, 951, 993, 1039, 1133, 1179, 1311, 1349, 1399, 1493, 1512, 1538, 1593, 1603, 1627, 1678, 1709, 1734, 1788, 1820, 1931, 1945, 1957, 1963, 1976, 2018, 2106, 2138, 2193, 2262, 2344, 2357, 2368, 2478, 2512, 2531, 2565, 2576, 2622, 2636, 2654, 2686, 2695, 2711, 2737, 2770, 2802, 2818, 2835, 2854, 2885, 2923, 3020, 3022, 3029, 3070, 3106, 3130, 3158, 3188, 3206, 3223, 3238, 3281, 3302, 3354, 3368, 3422, 3556, 3716, 3821, 3838, 3901, 3914, 4031, 4140, 4239, 4254, 4348, 4419, 4468, 4558, 4706, 4711, 4768, 4784, 4811, 4913, 4929, 4952, 4994, 5015, 5018, 5179, 5341, 5349, 5405, 5452, 5564, 5634, 5772, 5802, 5874, 5903, 5910, 5947, 5951, 5976, 6013, 6025, 6027, 6092, 6153, 6160], 'subunit': [22, 257, 1313], 'of': [23, 34, 41, 70, 73, 91, 99, 112, 125, 147, 150, 156, 214, 218, 229, 258, 269, 276, 305, 308, 326, 334, 347, 360, 382, 385, 391, 449, 453, 464, 491, 515, 536, 722, 866, 898, 941, 946, 961, 976, 980, 989, 997, 1021, 1025, 1032, 1037, 1072, 1123, 1142, 1193, 1299, 1308, 1314, 1323, 1330, 1345, 1353, 1372, 1401, 1430, 1447, 1488, 1533, 1569, 1601, 1648, 1659, 1688, 1692, 1717, 1725, 1732, 1769, 1793, 1798, 1816, 1822, 1828, 1850, 1871, 1881, 1921, 1928, 1969, 1993, 2029, 2035, 2061, 2112, 2180, 2186, 2195, 2202, 2241, 2244, 2259, 2282, 2290, 2308, 2338, 2353, 2363, 2366, 2377, 2395, 2404, 2437, 2443, 2454, 2480, 2527, 2544, 2580, 2590, 2595, 2626, 2639, 2673, 2728, 2731, 2741, 2746, 2753, 2759, 2780, 2788, 2804, 2812, 2825, 2831, 2841, 2845, 2848, 2860, 2866, 2872, 2921, 2953, 2961, 2968, 2978, 2987, 3014, 3036, 3042, 3050, 3056, 3076, 3096, 3103, 3140, 3166, 3257, 3274, 3288, 3327, 3363, 3376, 3392, 3398, 3405, 3493, 3506, 3513, 3521, 3531, 3574, 3587, 3670, 3699, 3714, 3736, 3745, 3752, 3775, 3781, 3869, 3883, 3885, 3909, 3920, 3943, 4049, 4104, 4112, 4126, 4148, 4179, 4191, 4225, 4252, 4259, 4281, 4363, 4475, 4491, 4552, 4564, 4568, 4582, 4587, 4599, 4621, 4669, 4675, 4680, 4704, 4815, 4855, 4936, 4948, 4997, 5010, 5028, 5037, 5043, 5109, 5122, 5134, 5142, 5153, 5162, 5168, 5174, 5189, 5218, 5242, 5269, 5275, 5283, 5345, 5403, 5491, 5509, 5623, 5642, 5709, 5756, 5764, 5861, 5872, 5922, 5979, 6004, 6019, 6030, 6034, 6082, 6104, 6145, 6148, 6156, 6163, 6186, 6193], 'prolyl-4-hydroxylase': [24, 259], 'microsomal': [26, 261], 'triglyceride': [27, 262], 'transfer': [28, 263], 'protein.': [29, 264], 'At': [30, 76, 265, 311, 1876, 3321, 3659, 4982], 'lower': [32, 267, 3440], 'concentration': [33, 268, 1827, 1870, 1920, 1992, 2258, 2312, 3505, 5844, 5885], '0.2': [35, 270, 3514], 'μm,': [36, 80, 271, 315, 2261], 'PDI': [37, 64, 81, 100, 132, 152, 173, 188, 272, 299, 316, 335, 367, 387, 408, 423, 627, 899, 950, 981, 1026, 1038, 1125, 1150, 1185, 1203, 1370, 1402, 1418, 1448, 1469, 1592, 1602, 1615, 1649, 1733, 1800, 1863, 1962, 2037, 2063, 2105, 2187, 2203, 2292, 2302, 2367, 2439, 2464, 2481, 2530, 2546, 2564, 2582, 2597, 2611, 2680, 2748, 2790, 2805, 2826, 2853, 2874, 2893, 2929, 2970, 3019, 3058, 3069, 3105, 3129, 3187, 3205, 3222, 3237, 3280, 3315, 3367, 3378, 3394, 3418, 3434, 3517, 3555, 3575, 3664, 3679, 3694, 3737, 3754, 3783, 3862, 3887, 3913, 3932, 4088, 4113, 4139, 4183, 4192, 4244, 4282, 4364, 4401, 4495, 4507, 4553, 4600, 4622, 4670, 4691, 4750, 4928, 4970, 4980, 5030, 5065, 5095, 5112, 5154, 5236, 5284, 5325, 5404, 5427, 5451, 5492, 5714, 5816, 5839, 5868, 5880, 5904, 5934, 5960, 6005, 6035, 6054, 6073, 6115, 6164, 6168], 'facilitated': [38, 273, 3518], 'the': [39, 60, 71, 110, 138, 162, 183, 205, 215, 226, 274, 295, 306, 345, 373, 397, 418, 440, 450, 461, 473, 489, 509, 513, 530, 723, 736, 763, 767, 773, 781, 864, 872, 895, 901, 931, 944, 947, 974, 983, 987, 990, 995, 998, 1002, 1022, 1030, 1120, 1124, 1140, 1191, 1296, 1321, 1328, 1343, 1346, 1354, 1369, 1389, 1394, 1414, 1467, 1472, 1527, 1545, 1656, 1664, 1672, 1681, 1686, 1689, 1693, 1721, 1791, 1799, 1851, 1882, 1891, 1938, 1947, 1997, 2015, 2025, 2033, 2059, 2073, 2091, 2144, 2178, 2184, 2191, 2209, 2242, 2269, 2280, 2288, 2306, 2322, 2325, 2339, 2345, 2351, 2361, 2364, 2375, 2393, 2402, 2409, 2420, 2434, 2441, 2452, 2487, 2498, 2506, 2510, 2516, 2520, 2532, 2545, 2555, 2562, 2574, 2577, 2581, 2593, 2616, 2624, 2628, 2637, 2671, 2726, 2729, 2732, 2739, 2744, 2761, 2764, 2772, 2777, 2785, 2810, 2822, 2832, 2836, 2846, 2858, 2861, 2870, 2892, 2919, 2951, 2959, 2966, 2976, 2985, 3012, 3015, 3034, 3037, 3043, 3054, 3093, 3125, 3137, 3141, 3153, 3175, 3201, 3210, 3213, 3228, 3250, 3255, 3258, 3272, 3286, 3291, 3295, 3318, 3322, 3325, 3336, 3347, 3361, 3373, 3390, 3396, 3403, 3491, 3519, 3529, 3538, 3551, 3571, 3585, 3588, 3668, 3697, 3712, 3723, 3743, 3763, 3776, 3779, 3782, 3809, 3861, 3867, 3873, 3881, 3886, 3907, 3918, 3928, 4035, 4047, 4050, 4124, 4135, 4144, 4149, 4177, 4188, 4208, 4223, 4250, 4257, 4349, 4359, 4386, 4396, 4473, 4489, 4550, 4562, 4585, 4596, 4617, 4663, 4676, 4813, 4819, 4823, 4886, 4902, 4918, 4937, 4945, 4961, 4983, 4986, 4995, 5008, 5013, 5020, 5024, 5029, 5041, 5074, 5094, 5100, 5130, 5140, 5145, 5151, 5163, 5172, 5185, 5190, 5204, 5216, 5227, 5240, 5267, 5273, 5280, 5316, 5322, 5324, 5338, 5342, 5347, 5350, 5419, 5433, 5439, 5443, 5487, 5501, 5621, 5627, 5639, 5706, 5721, 5736, 5739, 5762, 5774, 5783, 5792, 5806, 5820, 5825, 5847, 5859, 5870, 5920, 5924, 5938, 5955, 6000, 6017, 6028, 6046, 6059, 6064, 6072, 6080, 6089, 6093, 6102, 6111, 6146, 6149, 6154, 6158, 6170, 6191], 'aggregation': [40, 87, 275, 322, 2194, 2264, 2307, 3488, 3520, 3669, 3758, 3788, 3814, 3868, 3892, 3922, 4098, 4195, 5871], 'unfolded': [42, 277, 3746, 4492, 4555, 4795, 5454], 'rabbit': [43, 278, 554, 1515, 1570, 2021], 'muscle': [44, 279, 555, 1571], 'creatine': [45, 280, 556, 1221], 'kinase': [46, 281, 1222], '(CK)': [47, 282], 'exhibited': [49, 284, 2696], 'anti-chaperone': [50, 285, 3438, 3572, 5876], 'activity,': [51, 286], 'which': [52, 287, 506, 529, 875, 1433, 2382, 2406, 2675, 2916, 3193, 3283, 3308, 3400, 4241, 4659, 4772, 4973, 5005, 5137, 5830, 5856, 5970, 5981], 'was': [53, 68, 104, 168, 223, 288, 303, 339, 403, 458, 876, 1027, 1128, 1293, 1358, 1475, 1499, 1506, 1518, 1522, 1541, 1573, 1720, 1831, 1843, 1873, 1884, 1915, 1935, 1983, 1987, 2002, 2043, 2069, 2159, 2167, 2204, 2265, 2275, 2284, 2319, 2398, 2666, 2676, 2910, 2924, 3045, 3247, 3261, 3344, 3370, 3389, 3536, 3540, 3548, 3793, 3815, 3831, 3846, 3926, 4117, 4231, 4353, 4481, 4487, 4571, 4605, 4817, 4844, 4891, 4905, 4921, 4940, 4964, 4978, 5032, 5067, 5104, 5128, 5233, 5415, 5703, 5761, 5961, 6055], 'shown': [54, 289, 2646, 3118, 4699, 4845], 'be': [56, 291, 778, 2449, 2631, 2707, 2720, 2807, 2927, 2982, 3000, 3090, 3217, 3232, 3313, 3410, 3682, 3709, 3857, 3894, 4197, 4215, 4393, 4673, 4701, 4747, 4895, 4967, 5060, 5182, 5211, 5252, 5301, 5357, 5430, 5446, 5618, 6076], 'mainly': [57, 292, 4203], 'due': [58, 108, 293, 343, 2450, 2949, 4122, 5183, 5336, 6087], 'hydrophobic': [61, 296, 879, 1391, 4136, 4205, 5769, 5854], 'interactions': [62, 297, 1392], 'between': [63, 298, 648, 949, 2561, 2852, 2955, 3018, 3204, 3366, 3912, 4037, 4138, 5111, 5448, 5901], 'CK': [66, 94, 102, 134, 230, 301, 329, 337, 369, 465, 1301, 1315, 1324, 1374, 1431, 1572, 1594, 1604, 1632, 1872, 1933, 1964, 2031, 2042, 2107, 2175, 2189, 2196, 2235, 2246, 2283, 2309, 2326, 2341, 2348, 2369, 2380, 2397, 2412, 2444, 2491, 2591, 2619, 2693, 2734, 2792, 2817, 2855, 2867, 2963, 3051, 3071, 3108, 3142, 3189, 3241, 3252, 3329, 3338, 3343, 3369, 3380, 3416, 3428, 3495, 3522, 3557, 3671, 3700, 3729, 3747, 3787, 3813, 3870, 3891, 3915, 3921, 4107, 4115, 4175, 4194, 4212, 4253, 4262, 4493, 4556, 4569, 4591, 4775, 4797, 4816, 4856, 4884, 4998, 5022, 5038, 5101, 5126, 5158, 5169, 5220, 5643, 5710, 5724, 5873, 5917, 5928, 5990, 6011], 'independent': [69, 304, 3942], 'cross-linking': [72, 307, 1071, 1192, 2952, 3582, 3586, 4224, 4474, 5108], 'bonds.': [75, 310, 1195, 2459, 3590, 4132, 4228, 5369], 'concentrations': [77, 312, 1600, 1797, 2294, 3441, 3578, 3661, 3689, 4091], 'above': [78, 313, 2323, 3251], '1': [79, 148, 171, 175, 314, 383, 406, 410, 2297, 4926, 4930], 'acted': [82, 317, 4100], 'protector': [85, 320, 4096, 5967], 'against': [86, 321, 4097, 5968], 'but': [88, 323, 2423, 3925, 4099, 4576, 5114, 5365], 'inhibitor': [90, 325, 4103, 5978], 'reactivation': [92, 103, 327, 338, 2192, 2281, 2442, 2589, 2694, 2793, 3381, 3698, 3744, 4105, 4116, 4213, 4251], 'during': [93, 328, 3523, 3923, 4106, 4261, 4774, 4822], 'refolding.': [95, 330, 3417, 3524, 4108, 5159, 5221, 5991], 'The': [96, 331, 494, 824, 1382, 1567, 1599, 1705, 1796, 1868, 2157, 2372, 2588, 2829, 2864, 3008, 3170, 3511, 3750, 4109, 4270, 4381, 4546, 4580, 4735, 4933, 4957, 5120, 5160, 5897, 5992], 'inhibition': [97, 332, 2435, 2690, 2786, 2823, 3374, 3706, 4110, 4209, 5912], 'effect': [98, 333, 2185, 2436, 2660, 2691, 2699, 2787, 2824, 3375, 3707, 4111, 4190, 4210, 5121, 5913], 'on': [101, 336, 1597, 1757, 1776, 2188, 2440, 2490, 2692, 2791, 2827, 3379, 4114, 4193, 4211, 5125, 5638], 'further': [105, 340, 1186, 1385, 2170, 3040, 3181, 3358, 3526, 4118, 4232, 4660, 4941, 5201, 5831, 5889, 5908, 6014, 6143], 'characterized': [106, 341, 1363, 2925, 4119, 4285, 4781, 4942], 'formation': [111, 346, 539, 970, 1344, 2453, 2811, 2847, 2977, 3035, 3362, 3530, 3908, 4125, 4258, 4586, 5274, 5763, 5860, 6018], 'PDI-CK': [113, 348, 1347, 1406, 2427, 2502, 2862, 2979, 3348, 4127, 4763, 5191, 5421, 6048], 'complexes': [114, 129, 349, 364, 1357, 1361, 2455, 2980, 3017, 3044, 3202, 3365, 4128, 4890, 4908, 4924, 5017, 5894], 'through': [115, 350, 1160, 1190, 2456, 4129, 4204, 4222, 5768, 5797, 5853, 6023], 'intermolecular': [116, 351, 2457, 2813, 2849, 3533, 4130, 4226, 4476, 5898, 6020, 6060], 'bonds,': [118, 353, 4478, 6062], 'process': [120, 355, 2271, 4825, 5103, 5217, 5294], 'involving': [121, 356], 'Cys-36': [122, 357, 1398, 2477, 2801, 2954, 2973, 3028, 4274, 4467, 4575, 6024], 'Cys-295': [124, 359, 1400, 2479, 2803, 3030, 4469, 4583, 4613, 4668, 6026], 'PDI.': [126, 234, 361, 469, 1217, 1300, 3148, 5624], 'Two': [127, 362, 5754], 'disulfide-linked': [128, 363, 1366, 3016, 3364, 4762, 5892], 'containing': [130, 365, 1466, 1861, 1961, 2104, 2972, 3068, 4909, 4925, 5332, 5363, 6084], 'both': [131, 366, 2573, 3185, 3278, 3554, 5346, 6157], 'were': [135, 145, 370, 380, 1362, 1393, 1403, 1495, 1530, 1595, 1605, 1755, 1774, 1808, 1940, 1949, 1971, 2093, 2114, 2126, 2146, 2417, 2473, 2494, 2523, 2537, 2559, 2584, 2819, 2879, 3031, 3078, 3180, 3200, 3593, 4389, 4470, 4780, 5758, 6006], 'obtained,': [136, 371], 'large,': [139, 374], 'soluble': [140, 375, 5399, 5834, 5893], 'aggregates': [141, 376, 2422, 4260, 5767], 'around': [142, 165, 377, 400, 3297], '400': [143, 378, 2076], 'kDa': [144, 379, 3299], 'composed': [146, 381], 'molecule': [149, 384], 'tetrameric': [151, 386, 3314, 3393, 5933], '2': [154, 389, 1874, 1929, 2133, 2260, 3507, 4238, 4910, 4914], 'molecules': [155, 390, 2413], 'inactive': [157, 392, 4801, 4852, 4897, 5743, 5826, 5925], 'intermediate': [158, 393, 4854, 5746, 5828, 5927], 'dimeric': [159, 172, 176, 394, 407, 411, 3221, 3225, 3236, 3240, 4802, 4853, 4898, 4911, 4915, 4927, 4931, 5450, 5723, 5744, 5827, 5926, 5930], 'CK,': [160, 219, 395, 454, 553, 3021, 3131, 3226, 3282, 4972], 'whereas': [161, 396, 772, 2554, 2702, 2901, 3227, 3842, 4207, 4479, 4917, 6063], 'smaller': [163, 398], 'one,': [164, 399, 4771], '200': [166, 401, 3168, 3298], 'kDa,': [167, 402], 'formed': [169, 404, 3203, 4968, 5106, 5447], 'by': [170, 233, 405, 468, 1042, 1367, 1846, 2071, 2172, 2287, 2401, 2415, 2586, 2882, 2932, 2935, 2984, 3064, 3099, 3146, 3190, 3542, 3711, 3896, 4182, 4234, 4782, 4943, 4969, 5034, 5107, 5116, 5198, 5359, 5407, 5713, 6058], 'CK.': [177, 412, 2828, 3207, 4602, 4684, 4932], 'To': [178, 413, 2460, 3525], 'our': [179, 211, 414, 446, 1233, 1410, 3485, 4463, 4759, 5635, 6044, 6105], 'knowledge': [180, 415, 988, 1411], 'this': [181, 208, 416, 443, 1016, 1170, 1219, 1412, 2462, 3275, 3705, 4559, 4976, 5048, 5304, 5308, 5424, 5632, 5866, 5996, 6126], 'is': [182, 417, 507, 520, 540, 628, 937, 1001, 1165, 1172, 1181, 1198, 1302, 1413, 4044, 4143, 4172, 4614, 4692, 5288, 5481, 5817, 5840, 5881, 5914], 'first': [184, 419, 902, 1415, 2880], 'study': [185, 213, 420, 448, 826, 1220, 4610, 4717, 5049], 'revealing': [186, 421], 'that': [187, 422, 762, 1119, 1149, 1155, 1209, 1387, 1417, 1435, 1724, 2279, 2337, 2408, 2433, 2572, 2757, 2800, 3027, 3195, 3271, 3285, 3310, 3341, 3360, 3402, 3433, 3550, 3800, 3859, 3906, 4086, 4243, 4466, 4488, 4501, 4570, 4607, 4612, 4662, 4690, 4794, 4812, 4846, 4975, 5007, 5097, 5133, 5139, 5203, 5226, 5442, 5609, 5720, 5999, 6016, 6125], 'could': [189, 424, 1419, 2236, 2303, 2383, 2706, 2782, 2981, 2999, 3089, 3216, 3231, 3665, 3708, 3864, 3893, 4092, 4196, 4214, 4248, 4798, 4848, 5059, 5299], 'switch': [190, 425, 1420, 5612, 6029], 'its': [191, 198, 426, 433, 935, 952, 959, 1006, 1130, 1188, 1421, 1428, 1455, 2387, 3944, 4141, 4200, 4218, 4292, 5156, 5265, 5973, 5985, 6009, 6041], 'conformation': [192, 427, 1422], 'from': [193, 428, 1423, 1479, 1496, 1500, 1508, 1519, 1523, 2419, 2426, 2857, 3127, 3346, 3352, 3580, 4595, 4737, 5023, 5206, 5229, 5260, 5310, 5613, 5907, 5937, 5972, 5984, 6097], 'dimer': [194, 429, 1424, 1443, 3406, 4705, 4738, 5207, 5230, 5263, 5311, 5614, 5786, 6031, 6159], 'tetramer': [196, 431, 1426, 1445, 2930, 2944, 3408, 4707, 5031, 5066, 5096, 5209, 5232, 5261, 5313, 5326, 5616, 6033, 6074, 6098, 6161], 'in': [197, 207, 432, 442, 488, 512, 522, 871, 958, 964, 1029, 1129, 1232, 1376, 1405, 1427, 1454, 1655, 1680, 1713, 1745, 1790, 1834, 2032, 2058, 2177, 2310, 2347, 2445, 2486, 2501, 2509, 2519, 2592, 2618, 2642, 2647, 2722, 2725, 2743, 2763, 2776, 2794, 2809, 2869, 2876, 2965, 3053, 3092, 3119, 3122, 3136, 3174, 3382, 3414, 3425, 3561, 3598, 3672, 3701, 3718, 3722, 3778, 3795, 3801, 3808, 3823, 3872, 4046, 4264, 4277, 4291, 4385, 4399, 4423, 4472, 4505, 4561, 4584, 4714, 4777, 4885, 4960, 4989, 5000, 5040, 5047, 5069, 5099, 5144, 5155, 5166, 5171, 5215, 5235, 5238, 5264, 5285, 5303, 5321, 5423, 5432, 5489, 5496, 5620, 5631, 5748, 5773, 5819, 5858, 5989, 5995, 6008, 6040, 6078, 6114, 6121, 6131, 6133, 6139, 6151], 'foldase.': [202, 437, 4757], 'According': [203, 438, 1684, 2614, 3208, 4878, 5625], 'observations': [206, 441, 3592, 5630, 5994], 'research': [209, 444, 5223, 5633, 5997], 'previous': [212, 447, 3599, 4716, 4791, 4882, 5075, 5636, 6112], 'folding': [216, 451, 514, 526, 966, 1159, 4803, 4899, 5241, 5640, 5745, 6081], 'pathways': [217, 452, 5641], 'working': [221, 456, 5701, 6106], 'model': [222, 457, 1228, 5440, 5702, 6107, 6127], 'proposed': [224, 459, 1118, 5704], 'for': [225, 460, 501, 735, 1176, 1205, 1614, 1631, 1886, 1911, 1924, 1973, 2116, 2132, 2140, 2152, 2169, 2539, 2709, 2821, 2912, 3002, 3033, 3080, 3372, 3558, 3817, 3833, 3848, 4174, 4395, 4749, 5062, 5193, 5315, 5330, 5505, 5705, 5916, 6052, 6173, 6188], 'molecular': [227, 462, 523, 2908, 2991, 3164, 3211, 3319, 3940, 5707], 'mechanism': [228, 463, 897, 1440, 5708], 'refolding': [231, 466, 1322, 1375, 1910, 2270, 2868, 2964, 3052, 3143, 3253, 3924, 4048, 4263, 4776, 4809, 4824, 5039, 5102, 5127, 5170, 5268, 5711, 5737, 6012], 'catalyzed': [232, 467, 5712], 'In': [470, 758, 1218, 2994, 3484, 4133, 4758, 5865, 5958, 6043], 'eukaryotes,': [471], 'all': [472, 1134, 1161, 1946, 2528, 2891, 3559, 3860, 4880, 5070], 'nascent': [474], 'outer': [475], 'membrane': [476], 'secreted': [478], 'proteins': [479, 1076, 1208, 1458, 4682, 5271, 5517, 6083], 'are': [480, 1651, 1695, 1707, 1802, 2645, 5935], 'synthesized': [481], 'fold': [483], 'their': [485, 1735], 'native': [486, 502, 2245, 2388, 3107, 5276, 5286, 5333, 5367, 5722, 5807, 5956], 'structures': [487, 979, 2579, 6155], 'lumen': [490], 'endoplasmic': [492], 'reticulum.': [493], 'specialized': [495], 'compartment': [496], 'provides': [497, 766, 1151], 'favorable': [499], 'environment': [500, 1154], 'bond': [504, 538, 3535, 4171], 'formation,': [505], 'often': [508], 'rate-limiting': [510, 4820], 'step': [511, 3413, 4821, 5214], 'many': [516, 5510, 6122], 'proteins.': [517, 5244, 6175], 'Endoplasmic': [518], 'reticulum': [519], 'abundant': [521, 532], 'chaperones': [524, 5567, 6123], 'catalysts,': [527], 'among': [528], 'most': [531, 3342], 'efficient': [534], 'catalyst': [535], '(PDI,': [544], '1The': [545], 'abbreviations': [546], 'used': [547, 1885, 1972, 2139, 2495], 'are:': [548], 'PDI,': [549, 942, 1078, 1660, 2781, 3307, 3819, 5136, 5931], 'isomerase;': [552], 'kinase;': [557], 'GdnHCl,': [558, 1491], 'guanidine': [559], 'hydrochloride;': [560], 'SEC,': [561], 'size': [562], 'exclusion': [563], 'chromatography;': [564, 569], 'HPLC,': [565], 'high': [566, 977, 2990, 4090], 'performance': [567], 'liquid': [568], 'DTT,': [570, 2405, 2627, 2674, 3399, 5923], 'dithiothreitol;': [571], 'WT,': [572], 'wild': [573], 'type.': [574], 'EC': [575, 1224], '5.3.4.1)': [576], '(1.Ferrari': [577], 'D.M.': [578], 'Söling': [579], 'H.D.': [580], 'Biochem.': [581, 598, 664, 1108, 1263, 1282, 1621, 3649, 3953, 4159, 4520, 4867, 5599, 5654, 5673], 'J.': [582, 678, 714, 795, 815, 847, 916, 1053, 1091, 1107, 1262, 1560, 1622, 3448, 3472, 3607, 3631, 3650, 3954, 3969, 3987, 4010, 4158, 4301, 4369, 4408, 4446, 4521, 4643, 4866, 5379, 5463, 5523, 5548, 5590, 5598, 5653], '1999;': [583, 1563, 5551], '339:': [584], '1-10Crossref': [585], 'PubMed': [586, 606, 622, 672, 697, 753, 801, 819, 858, 925, 1064, 1095, 1112, 1248, 1269, 1288, 2229, 3459, 3481, 3618, 3640, 3654, 3958, 3978, 3998, 4014, 4026, 4063, 4080, 4163, 4312, 4328, 4343, 4378, 4414, 4457, 4525, 4541, 4654, 4730, 4837, 4873, 5089, 5390, 5474, 5534, 5559, 5576, 5603, 5660, 5679, 5695], 'Scopus': [587, 607, 623, 673, 698, 754, 802, 820, 859, 1065, 1096, 1113, 1249, 1270, 1289, 2230, 3460, 3619, 3655, 3959, 3999, 4015, 4027, 4064, 4164, 4313, 4329, 4344, 4415, 4458, 4526, 4542, 4655, 4731, 4838, 4874, 5090, 5391, 5475, 5535, 5560, 5577, 5604, 5661, 5680, 5696], '(441)': [588], 'Google': [589, 609, 625, 675, 700, 756, 804, 822, 861, 926, 1067, 1098, 1115, 1251, 1272, 1291, 2232, 3462, 3482, 3621, 3641, 3657, 3961, 3979, 4001, 4017, 4029, 4066, 4081, 4166, 4315, 4331, 4346, 4379, 4417, 4460, 4528, 4544, 4657, 4733, 4840, 4876, 5092, 5393, 5477, 5537, 5562, 5579, 5606, 5663, 5682, 5698], 'Scholar,': [590, 610, 676, 701, 805, 1099, 1252, 1273, 3463, 3622, 3642, 3962, 3980, 4002, 4018, 4067, 4316, 4332, 4529, 5580, 5664, 5683], '2.Freedman': [591], 'R.B.': [592, 612, 658, 703, 813, 844, 1089, 1105, 4053, 4156, 4443, 4511, 4533, 4640], 'Hirst': [593, 659], 'T.R.': [594, 660], 'Tuite': [595, 661], 'M.F.': [596, 662], 'Trends.': [597, 663], 'Sci.': [599, 665, 1244, 1585, 1641, 1903, 4537], '1994;': [600, 666, 3475, 3634, 3972, 4372, 4727, 5086], '19:': [601, 667], '331-336Abstract': [602, 668], 'Full': [603, 669, 692, 694, 853, 855, 922, 1059, 1061, 3454, 3456, 3478, 3613, 3615, 3637, 3975, 3993, 3995, 4075, 4077, 4307, 4309, 4325, 4375, 4452, 4454, 4649, 4651, 5385, 5387, 5469, 5471, 5529, 5531, 5554, 5556], 'Text': [604, 670, 693, 695, 854, 856, 923, 1060, 1062, 3455, 3457, 3479, 3614, 3616, 3638, 3976, 3994, 3996, 4076, 4078, 4308, 4310, 4326, 4376, 4453, 4455, 4650, 4652, 5386, 5388, 5470, 5472, 5530, 5532, 5555, 5557], 'PDF': [605, 671, 696, 857, 924, 1063, 3458, 3480, 3617, 3639, 3977, 3997, 4079, 4311, 4327, 4377, 4456, 4653, 5389, 5473, 5533, 5558], '(656)': [608, 674], '3.Freedman': [611], 'Klappa': [613, 829, 1079, 4054, 4428, 4534, 4625], 'P.': [614, 807, 830, 1083, 1101, 1557, 4055, 4152, 4429, 4509, 4535, 4626, 5588], 'Ruddock': [615, 808, 845, 1084, 4056, 4444, 4518, 4641], 'L.W.': [616, 809, 846, 1085, 4057, 4445, 4519, 4531, 4642], 'EMBO': [617, 814, 1090, 4009, 4058], 'Rep.': [618, 4059], '2002;': [619, 4023, 4060, 5526], '3:': [620, 4061], '136-140Crossref': [621, 4062], '(169)': [624, 4065], 'Scholar).': [626, 720, 757, 823, 927, 1068, 1566, 1590, 1646, 1908, 3483, 3658, 4082, 4167, 4380, 4461, 4545, 4734, 4841, 4877, 5478], 'multidomain': [630], 'multifunction': [632], 'homodimer.': [633], 'It': [634, 2274, 3547, 3854, 4685, 5480], 'comprises': [635], 'four': [636, 1135, 1317], 'thioredoxin-like': [637], 'domains,': [638, 726], 'a,': [639], 'b,': [640], 'b′,': [641], 'a′,': [643, 729], 'plus': [644], 'linker': [646], 'region': [647], 'b′': [649, 764, 873, 1131, 1682, 2521, 2778, 4387], 'a′': [651, 5146], 'C-terminal': [654, 1673, 2513, 4350], 'acid': [655], 'extension': [656], '(2.Freedman': [657], '4.Kemmink': [677], 'Darby': [679, 810, 1086], 'N.J.': [680, 790, 811, 1087, 4069, 4403], 'Dijkstra': [681], 'K.': [682], 'Nilges': [683], 'M.': [684, 832, 4431, 4513, 4628], 'Creighton': [685], 'T.E.': [686], 'Curr.': [687, 4070], 'Biol.': [688, 715, 797, 848, 917, 1054, 1265, 1284, 1561, 3449, 3473, 3608, 3632, 3970, 3988, 4071, 4302, 4370, 4410, 4447, 4644, 4869, 5380, 5464, 5524, 5549, 5656, 5675], '1997;': [689, 1109, 3651, 3955, 4011, 4160], '7:': [690], '239-245Abstract': [691], '(197)': [699], '5.Freedman': [702], 'Gane': [704], 'P.J.': [705], 'Hawkins': [706, 1102, 4153], 'H.C.': [707, 1103, 4154], 'Hlodan': [708], 'R.': [709, 794, 3469, 3628, 4407], 'McLaughlin': [710], 'S.H.': [711], 'Parry': [712], 'J.W.': [713], 'Chem.': [716, 849, 918, 1055, 3450, 3474, 3609, 3633, 3971, 3989, 4303, 4371, 4448, 4645, 5381, 5465, 5525, 5550], '1998;': [717, 798, 816, 1092, 2226, 4411], '379:': [718], '321-328Google': [719], 'Each': [721, 2165], 'two': [724, 1661, 1670, 1679, 2517, 3132, 3171, 3197, 3220, 3224, 4761, 5449, 5453, 6001], 'catalytic': [725, 896, 1007, 4397], 'contains': [730, 1316], 'WCGHCK': [732], 'motif,': [733], 'responsible': [734, 2820, 3032, 3371], 'activity': [738, 960, 1189, 1371, 1887, 1934, 2243, 2327, 2394, 2735, 3573, 3725, 3946, 4202, 4221, 4294, 4362, 4398, 5877, 6116], '(6.Edman': [739], 'J.C.': [740], 'Ellis': [741], 'L.': [742, 836, 4435, 4632], 'Blacher': [743], 'R.W.': [744], 'Roth': [745], 'R.A.': [746, 834, 4433, 4630], 'Rutter': [747], 'W.J.': [748, 4320], 'Nature.': [749], '1985;': [750], '317:': [751], '267-270Crossref': [752], '(477)': [755], 'vitro': [759, 6134], 'studies': [760, 3600], 'showed': [761, 2548, 3270, 4085, 5719], 'domain': [765, 2522, 2779, 4388, 5147], 'principle': [768], 'peptide': [769, 1158, 1474], 'binding': [770, 869, 933, 1023, 1126, 1141, 4150, 4425, 4490, 4551, 4598, 4619, 4665, 4678], 'site,': [771, 2515], 'other': [774, 1528, 5566, 6132], 'domains': [775, 1136], 'should': [776, 3680, 3855, 6165], 'also': [777, 2431, 2524, 3856, 4593, 4672, 5429, 5482, 6129], 'involved': [779, 1404, 2808, 4471, 5234, 5431, 5619], 'when': [780, 2607, 2664, 3762, 4041], 'substrates': [783, 953, 4051, 4142, 5331], 'have': [784, 1014, 1211, 2947, 4497, 4742], 'substantial': [786], 'secondary': [787, 1309, 2026, 2575], 'structure': [788], '(7.Darby': [789, 4402], 'Penka': [791, 4404], 'E.': [792, 2216, 4405, 5522], 'Vincentelli': [793, 4406], 'Mol.': [796, 4409], '276:': [799, 4412], '239-247Crossref': [800, 4413], '(152)': [803, 4416], '8.Klappa': [806], 'Freedman': [812, 843, 1088, 1104, 4155, 4442, 4510, 4532, 4639], '17:': [817, 1093], '927-935Crossref': [818, 1094], '(297)': [821, 1097], 'latest': [825], '(9.Pirneskoski': [827, 4426, 4623], 'A.': [828, 3465, 3624, 4427, 4624, 5541, 5586], 'Lobell': [831, 4430, 4627], 'Williamson': [833, 4432, 4629], 'Byrne': [835, 4434, 4631], 'Alanen': [837, 4436, 4633], 'H.I.': [838, 4437, 4634], 'Salo': [839, 4438, 4635], 'K.E.': [840, 4439, 4636], 'Kivirikko': [841, 4440, 4637], 'K.I.': [842, 4441, 4638], '2004;': [850, 4449, 4646], '279:': [851, 4450, 4647], '10374-10381Abstract': [852, 4451, 4648], '(143)': [860, 4459, 4656], 'Scholar)': [862, 1116, 1626, 4418, 5394], 'demonstrated': [863, 2656, 3935, 4504], 'existence': [865, 3013, 5009], 'ligand': [868, 4618, 4664], 'site': [870, 1127, 1667, 1675, 2767, 2774, 4280, 4352, 4383, 4620, 4666], 'domain,': [874, 1132], 'small': [878, 5514], 'pocket': [880], 'defined': [881], 'Leu-242,': [883], 'Leu-244,': [884], 'Phe-258,': [885], 'Ile-272.': [887], 'Much': [888], 'effort': [889], 'has': [890, 3430, 3933, 4283, 4686], 'been': [891, 2948, 3431, 3934, 4284, 4503, 4687, 4698, 4744], 'devoted': [892], 'investigating': [894], 'since': [900], 'report': [903, 1416, 5076], 'published': [904, 1546], 'more': [905, 1438, 2356, 2358, 2424, 3024, 3386, 3772, 4271, 4357, 4892], 'than': [906, 1216, 2296, 2336, 2668, 3584], '40': [907], 'years': [908], 'ago': [909], '(10.Goldberger': [910], 'R.F.': [911], 'Epstein': [912], 'C.J.': [913], 'Anfisen': [914], 'C.B.': [915], '1963;': [919], '238:': [920], '628-635Abstract': [921], 'As': [928, 2390, 2888, 3083, 3117, 5319], 'enzyme,': [930], 'specific': [932, 1153, 4547, 4597, 4677, 5117, 5314, 6171], 'substrate': [936, 1298, 4424, 5317, 5362, 5456], 'basic': [939], 'property': [940], 'nature': [945, 6147], 'interaction': [948, 4137, 5770], 'plays': [954, 6036], 'crucial': [956, 1452, 6038], 'role': [957, 1453, 4290, 6039], 'accelerating': [962], 'steps': [963], 'associated': [967, 1441], 'with': [968, 1305, 1378, 1442, 1765, 2009, 2052, 2078, 2119, 2128, 2161, 2199, 2268, 2293, 2360, 2466, 2609, 2816, 2905, 3060, 3110, 3596, 3789, 3799, 4590, 5851, 6110, 6200], 'or': [971, 982, 1074, 1174, 1213, 1379, 2053, 2198, 2333, 2974, 3004, 3061, 3111, 3565, 3790, 3850, 3875, 4267, 4275, 4756, 4888, 5498, 5932], 'isomerization.': [972], 'However,': [973, 1163, 3704, 4462, 5245, 5352, 6101], 'lack': [975], 'resolution': [978], 'PDI-substrate': [984, 999, 1356], 'complex': [985, 1000, 1034, 1439, 2503, 3087, 4959, 4977, 5192, 5348, 5400, 5414, 5422, 5435, 5444, 5835, 6049], 'limits': [986], 'pathway': [991], 'involved,': [992, 3537], 'thus,': [994, 1146, 1350], 'identification': [996, 5027], 'key': [1003], 'elucidating': [1005], 'mechanism.': [1008], 'Unfortunately,': [1009], 'only': [1010, 2549, 2898, 3304], 'few': [1012], 'reports': [1013], 'addressed': [1015], 'problem': [1017], 'directly.': [1018], 'Direct': [1019], 'evidence': [1020, 2844], 'ability': [1024], 'found': [1028, 2911, 3001, 3262, 3549, 3816, 3832, 3847, 4965, 5068, 5962], 'characterization': [1031, 2859, 3041], '(>500': [1035, 5436], 'kDa)': [1036, 5402, 6051], 'alcohol': [1040], 'dehydrogenase': [1041], 'gel': [1043, 5408], 'filtration': [1044, 5409], 'HPLC': [1045, 5410], 'analysis': [1046, 1384, 2118, 2171, 2493, 2937, 3357, 4787, 5036, 5200], '(11.Primm': [1047, 3442, 3601, 5373, 5457], 'T.D.': [1048, 3443, 3602, 5374, 5458], 'Walker': [1049, 3444, 3603, 5375, 5459], 'K.W.': [1050, 3445, 3604, 4334, 5376, 5460], 'Gilbert': [1051, 3446, 3470, 3605, 3629, 4337, 4367, 5377, 5461], 'H.F.': [1052, 3447, 3471, 3606, 3630, 4338, 4368, 5378, 5462], '1996;': [1056, 3451, 3610, 4340, 5382, 5466, 5573], '271:': [1057, 3452, 3611, 5383, 5467], '33664-33669Abstract': [1058, 3453, 3612, 5384, 5468], '(87)': [1066, 3461, 3620, 5392, 5476], 'By': [1069], 'chemical': [1070], 'peptides': [1073], 'nonnative': [1075, 2263, 2421], 'et': [1080, 5371], 'al.': [1081, 5372], '(8.Klappa': [1082], '12.Klappa': [1100], 'Eur.': [1106, 4157, 5597], '248:': [1110, 4161], '37-42Crossref': [1111, 4162], '(84)': [1114, 4165], 'recently': [1117], 'essential': [1121, 3412, 5213], 'core': [1122], 'might': [1137, 1210, 1449, 2448, 2806, 2946, 3312, 3409, 4496, 4592, 4671, 5181, 5210, 5295, 5327, 5356, 5428, 5445, 5617, 6075, 6128], 'contribute': [1138, 4356], 'large': [1143, 1157, 1177, 1207, 1306, 1457, 3806, 4681, 5243, 5270, 5398, 5765, 5862, 5891, 5939, 6047, 6174], 'peptides.': [1144], 'It,': [1145], 'seems': [1147], 'likely': [1148, 2425, 4893], 'facilitates': [1156, 5869], 'domains.': [1162], 'it': [1164, 1180, 1197, 3303, 3311, 4032, 4604, 4696, 4843, 5298, 5822], 'not': [1166, 1175, 1326, 2399, 2418, 3115, 3927, 4185, 4391, 4482, 4577, 4818, 5105, 5149, 5300, 5328, 5483], 'clear': [1167, 5484], 'yet': [1168, 5485], 'whether': [1169, 3528, 3871, 5486], 'hypothesis': [1171, 4230], 'true': [1173], 'proteins,': [1178], 'still': [1182, 1199, 3300, 3681, 5249], 'unknown': [1183], 'how': [1184, 1202, 6167], 'performs': [1187], 'Particularly,': [1196], 'mystery': [1201], 'acts': [1204], 'very': [1206, 5750, 5811], 'similar': [1212, 2677, 3334, 5417], 'larger': [1214, 2667], 'dimensions': [1215], '(CK,': [1223], '2.7.3.2),': [1225], '86-kDa': [1227], 'extensively': [1230], 'studied': [1231], 'laboratory': [1234], '(13.Ou': [1235], 'W.B.': [1236, 1277, 5668], 'Luo': [1237], 'W.': [1238], 'Park': [1239, 1257, 4861, 5648], 'Y.D.': [1240, 1258, 1275, 4862, 5649, 5666], 'Zhou': [1241, 1259, 1280, 1579, 1635, 1897, 4005, 4830, 4863, 5650, 5671, 5688], 'H.M.': [1242, 1260, 1281, 1580, 1636, 1898, 4831, 4864, 5651, 5672, 5689], '2001;': [1245, 1266, 1285, 4522, 4870, 5657, 5676], '10:': [1246], '2346-2353Crossref': [1247], '(55)': [1250], '14.Li': [1253], 'S.': [1254, 4858, 5645], 'Bai': [1255, 4859, 5646], 'J.H.': [1256, 4860, 5647], 'Int.': [1261, 4865, 5652], 'Cell': [1264, 1283, 4868, 5655, 5674], '33:': [1267, 4871, 5658], '279-286Crossref': [1268, 4872, 5659], '(35)': [1271, 4875, 5662], '15.Park': [1274, 5665], 'Ou': [1276, 5667], 'Yu': [1278, 5669], 'T.W.': [1279, 5670], '79:': [1286, 5677], '479-487Crossref': [1287, 5678], '(17)': [1290, 5681], 'Scholar),': [1292, 2233, 4030, 4347, 4658, 5093, 5538, 5563, 5607, 5699], 'chosen': [1294, 2115, 3079], 'homodimer': [1304], 'quantities': [1307], 'structures,': [1310], 'each': [1312, 2643, 4278], 'free': [1318, 1332, 2379, 2411], 'cysteines.': [1319], 'Because': [1320], 'did': [1325, 3741, 5148], 'need': [1327], 'oxidation': [1329], 'any': [1331, 3739, 4246], 'sulfhydryls': [1333], 'into': [1334, 1854, 2045, 2250, 2633, 3496, 5735], 'disulfides,': [1335], 'no': [1336, 2703, 2996, 3086, 3843, 4169, 5366], 'thiol-disulfide': [1337, 4180, 5339, 6090], 'interchange': [1338, 4181, 5340, 6091], 'reactions': [1339, 1939], 'would': [1340], 'occur': [1341], 'upon': [1342, 3490, 4805, 5730], 'complexes,': [1348, 4764], 'accumulation': [1352, 5355], 'long-lived': [1355], 'obtained.': [1359], 'These': [1360, 2429, 2569, 3350, 3591, 3903, 5196], 'being': [1365, 2248, 4121], 'comparing': [1368, 4944], 'assisting': [1373, 1456, 5157, 5239, 5266, 6010, 6079], 'solutions': [1377, 2447, 2865, 3102], 'without': [1380, 1471, 2054, 2197, 3062, 3112, 3738, 3791, 4245, 4971], 'DTT.': [1381], 'mutation': [1383, 6065], 'indicated': [1386, 2374, 2571, 2756, 3194, 4242, 4465, 4793], 'although': [1388, 2301, 3692, 3880, 4695, 5297, 5438], 'noncovalent': [1390], 'major': [1395, 3929, 4145, 5281, 6002], 'driving': [1396, 3930, 4146], 'force,': [1397], 'interactions.': [1407], 'Moreover,': [1408, 3732, 4603, 4842], 'catalysis': [1429, 4178], 'refolding,': [1432, 2190, 5909], 'implied': [1434, 6071], 'much': [1437], 'transition': [1446, 3404, 5205, 5228, 5259, 5309, 5508, 6096, 6150], 'play': [1450], 'refold.': [1460], 'Materials—The': [1461], 'plasmid': [1462, 6192], 'pBV220-PDI': [1463], '(5.20': [1464], 'kilobases)': [1465], 'human': [1468, 4400], 'gene': [1470], 'signal': [1473], 'generous': [1477], 'gift': [1478], 'Dr.': [1480, 6178], 'Y.': [1481, 1549, 4004, 4829, 5687, 6179], 'Gao,': [1482], 'Capital': [1483], 'Normal': [1484, 6182], 'University,': [1485, 6183], "People's": [1486, 6184], 'Republic': [1487, 6185], 'China.': [1489], 'Ultrapure': [1490], 'Tris,': [1492], 'ATP': [1494], 'Sigma.': [1497], 'DTT': [1498, 1914, 2057, 2131, 2318, 2354, 2416, 2742, 2922, 3063, 3113, 3246, 3289, 3715, 3768, 3792, 3897, 5011], 'Promega.': [1501], 'Mouse': [1502], 'anti-PDI': [1503, 2011], 'monoclonal': [1504, 2012], 'antibody': [1505, 1517, 2013, 2023], 'purchased': [1507], 'MBL': [1509], 'International': [1510], 'Corp,': [1511], 'horseradish': [1513, 2019], 'peroxidase-labeled': [1514, 2020], 'anti-mouse': [1516, 2022], 'DAKO.': [1520], 'N-Ethylmaleimide': [1521], 'Acros': [1524], 'Organics.': [1525], 'All': [1526, 1805, 1937, 2090, 2143], 'chemicals': [1529], 'local': [1531], 'products': [1532], 'analytical': [1534], 'grade.': [1535], 'Purification': [1537, 1716], 'Concentration': [1539], 'Determinations—PDI': [1540], 'purified': [1542], 'according': [1543, 1889, 3316], 'protocol': [1547], '(16.Gao': [1548], 'Yang': [1550, 4828, 5686], 'Z.W.': [1551], 'Hua': [1552], 'Z.L.': [1553], 'Gao': [1554, 6180], 'H.': [1555, 3646, 3950, 3964, 3982], 'Wan': [1556], 'Li': [1558], 'H.Y.': [1559], 'Eng.': [1562], '15:': [1564], '349-354Google': [1565], 'preparation': [1568], 'described': [1575, 5320], 'earlier': [1576], '(17.Yao': [1577, 1633, 1895], 'Q.Z.': [1578, 1634, 1896], 'Hou': [1581, 1637, 1899], 'L.X.': [1582, 1638, 1900], 'Tsou': [1583, 1639, 1901, 3967, 4722, 5081], 'C.L.': [1584, 1640, 1902, 3968, 4723, 5082], 'Sin.': [1586, 1642, 1904], '1982;': [1587, 1643, 1905], '25:': [1588, 1644, 1906], '1296-1302Google': [1589, 1645, 1907], 'Purified': [1591], 'homogeneous': [1596], 'SDS-PAGE.': [1598, 2174], 'measured': [1606, 2328], 'spectrophotometrically': [1607], 'at': [1608, 1663, 1671, 1785, 1810, 1838, 1865, 1942, 1951, 1965, 2065, 2075, 2087, 2095, 2108, 2135, 2148, 2599, 3072, 3152, 3162, 3439, 3576, 3687, 4089, 4708, 5841, 5882], '280': [1609], 'nm,': [1610], 'A0.1%1cm': [1611, 1628], '=': [1612, 1629], '0.9': [1613], '(18.Hu': [1616], 'C.H.': [1617], 'Wang': [1618, 3647, 3951, 3965, 3985, 4007, 4720, 5079], 'C.C.': [1619, 3648, 3952, 3966, 3986, 4008, 4020, 4721, 5080], 'Chin.': [1620], '1988;': [1623], '4:': [1624], '61-66Google': [1625], '0.88': [1630], 'Construction': [1647], 'Mutants—There': [1650], 'six': [1652, 2507], 'cysteine': [1653, 2762, 2775, 4567], 'residues': [1654], 'primary': [1657, 2016], 'sequence': [1658, 4498], 'located': [1662, 4615], 'N-terminal': [1665, 2765, 4272], 'active': [1666, 1674, 1737, 1740, 2514, 2766, 4279, 4351, 5785, 5793], '(a': [1668, 2768], 'domain),': [1669, 1677, 2769], '(a′': [1676], 'domain.': [1683], 'requirement': [1687], 'experiment,': [1690], 'some': [1691, 2467, 2988, 3884, 5565], 'cysteines': [1694, 2469, 2508, 2518, 4247, 4384], 'mutated': [1696, 2470], 'serines': [1698, 2472], 'give': [1700], 'rise': [1701], 'nine': [1703, 2533], 'mutants.': [1704], 'mutants': [1706, 1719, 1731, 2465, 2534, 2566, 2583, 2598, 2629, 3784, 3863, 5045], 'constructed': [1708, 2474, 2538, 5046], 'designated': [1710], 'listed': [1712], 'Table': [1714], 'I.': [1715], 'these': [1718, 3196, 4038, 4881, 5194], 'same': [1722, 3323, 4984, 5131], 'WT': [1726, 2181, 2291, 2438, 2529, 2563, 2610, 2679, 2789, 3104, 3128, 3147, 3186, 3279, 3306, 3377, 3516, 3693, 3818, 4087, 5135, 6053], 'PDI.Table': [1727], 'ICys': [1728], 'Ser': [1730], 'designationN-terminal': [1736], 'site36CGHC39b′': [1738], 'domainC-terminal': [1739], 'site380CGHC383DesignationCys295Cys326CGHCCysCysCGHCWt-PDI': [1741], '(NCC:BCC:CCC)CGHCCysCysSGHSNCC:BCC:CSSCGHSCysCysSGHSNCS:BCC:CSSSGHCCysCysSGHSNSC:BCC:CSSSGHSCysCysCGHCNSS:BCC:CCCSGHSCysCysSGHSNSS:BCC:CSSSGHSSerCysSGHSNSS:BSC:CSSSGHSCysSerSGHSNSS:BCS:CSSSGHSSerSerSGHSNSS:BSS:CSS': [1742], 'Open': [1743], 'table': [1744], 'new': [1747, 2989, 2997, 3133, 3172, 3198], 'tab': [1748], 'Biophysical': [1749], 'Analysis—Far': [1750], 'UV': [1751, 2085], 'circular': [1752], 'dichroism': [1753], 'spectra': [1754, 1773, 1807, 2543, 2558, 3095, 3177], 'recorded': [1756, 2160], 'Jasco': [1759], '725': [1760], 'spectrophotometer': [1761, 2086], 'using': [1762, 1780, 3048, 5360], 'cell': [1764], 'path': [1767], 'length': [1768], '0.1': [1770], 'cm.': [1771], 'Fluorescence': [1772], 'collected': [1775, 1809, 2168], 'F-2500': [1778], 'spectrofluorometer': [1779], '1-ml': [1782], 'cuvette,': [1783], 'excitation': [1784], '285': [1786], 'nm': [1787, 2077], 'emission': [1789], 'range': [1792], '300–400': [1794], 'nm.': [1795], 'species': [1801, 1864, 2064, 2547, 2641, 2875, 2894, 2971, 3059, 3755, 3888, 6066], '10': [1803, 1879, 1922, 2055, 2129, 2153, 3766], 'μm.': [1804, 1875], 'resultant': [1806], '25': [1811, 1839, 1943, 2088, 2136], '°C': [1812, 1840, 2137, 4710], 'average': [1815], 'five': [1817, 3077], 'scans.': [1818], 'Denaturation': [1819], 'Reactivation': [1821, 1842], 'CK—CK': [1823], '(with': [1824], 'final': [1826, 1869, 1919, 1991, 2257, 3504], '242': [1829], 'μm)': [1830], 'completely': [1832], 'denatured': [1833, 1852, 2041], '3': [1835, 1953], 'm': [1836, 2039], 'GdnHCl': [1837, 2040], 'overnight.': [1841], 'carried': [1844, 1984, 2003, 3046], 'out': [1845, 2004, 3047], '121-fold': [1848], 'dilution': [1849, 3492, 4806], 'enzyme': [1853], '30': [1855, 2046, 2251, 3497], 'mm': [1856, 1923, 2047, 2056, 2130, 2252, 3498, 3767], 'Tris-HCl': [1857, 2048, 2253, 3499], 'buffer': [1858, 2051, 2254, 3567, 3764, 3825, 3877, 4810], '(pH': [1859, 2049, 3500], '8.0)': [1860, 2050, 3501], 'various': [1862, 2062, 2200, 2747, 2873, 2969, 3057, 3753, 5044], 'different': [1866, 2066, 2596, 2600, 2605, 5057, 5063], 'concentrations.': [1867, 2067], 'suitable': [1877], 'intervals': [1878], 'μl': [1880], 'sample': [1883, 3144], 'assay': [1888], 'pH': [1892, 4712], 'colorimetry': [1893], 'method': [1894], 'After': [1909], '4': [1912, 4709], 'h,': [1913, 1930], 'added': [1916, 1988, 2320, 3248], 'incubation': [1926], 'period': [1927], 'then': [1932], 'remeasured.': [1936], 'conducted': [1941], '°C,': [1944], 'measurements': [1948, 2092], 'repeated': [1950, 2094], 'least': [1952, 2096], 'times.': [1954, 2098], 'Non-reduced': [1955], 'SDS-PAGE': [1956, 1975, 1982, 2008, 2884, 3269, 3356, 3544, 4786], 'Western': [1958, 1977, 2000, 2886], 'Blot': [1959], 'Analysis—Samples': [1960, 2103], 'molar': [1967, 2110, 2601, 3074], 'ratio': [1968, 2111, 2365, 3075], '5': [1970, 2113], 'non-reduced': [1974, 1981, 2007, 2883], 'blot': [1978, 2001], 'analysis.': [1979, 2142, 2541, 3066, 3082, 5411], 'Before': [1980], 'out,': [1985], 'N-ethylmaleimide': [1986], '5mm': [1994], 'stop': [1996], 'exchange.': [1999], 'after': [2005, 2247, 2350, 2623, 2670, 2738, 2918, 3395, 5809], '10%': [2006], 'mouse': [2010], 'antibody,': [2017], 'antibody.': [2027], 'Aggregation': [2028, 2068], 'Denatured': [2030], 'Presence': [2034, 2179], 'Various': [2036], 'Species—3': [2038], 'diluted': [2044, 2249, 5734], 'presence': [2060, 2594, 2745, 2871, 2967, 3055, 5042, 5173], 'followed': [2070], 'monitoring': [2072], 'turbidity': [2074], 'PerkinElmer': [2080], 'Life': [2081], 'Sciences': [2082], 'Lambda': [2083], 'Bio': [2084], '°C.': [2089], 'three': [2097, 2634], 'Size': [2099], 'Exclusion': [2100], 'Chromatography': [2101], '(SEC)': [2102], 'SEC': [2117, 2141, 2158, 2936, 3065, 3081, 3094, 3138, 3176, 3353, 4783, 4946, 5035, 5199], 'Superdex': [2121], 'HR200': [2122], 'column.': [2123], 'Then': [2124, 5788, 5941], 'samples': [2125, 2145, 2960, 3049, 3097, 3560], 'combined': [2127], 'h': [2134], 'centrifuged': [2147], '13,000': [2149], '×': [2150], 'g': [2151], 'min': [2154], 'before': [2155, 2621, 2736], 'loading.': [2156], 'ÄKTA': [2163], 'purifier.': [2164], 'peak': [2166, 2945, 3150, 3215, 3230, 3260, 3276, 3296, 3326, 4904, 4920, 4939, 4988, 4996, 5165], 'reduced': [2173, 3191, 3355, 3543, 4785], 'Refolding': [2176], 'PDI—To': [2182], 'characterize': [2183, 2497, 3527], 'amounts': [2201], 'investigated': [2205], 'first.': [2206], 'Similar': [2207, 5072], 'results': [2210, 2373, 2430, 2570, 3009, 3351, 3904, 4084, 4464, 4947, 5197, 5857], 'reported': [2211, 3432, 4390, 4611, 4745, 5396, 5503], 'previously': [2212], '(19.Leydier': [2213], 'C.': [2214, 2222, 2224], 'Clottes': [2215], 'Couthon': [2217], 'F.': [2218], 'Marcillat': [2219], 'O.': [2220], 'Ebel': [2221], 'Vial': [2223], 'Biochemistry.': [2225, 4339, 5572], '37:': [2227], '17579-17589Crossref': [2228], '(38)': [2231], 'GdnHCl-denatured': [2234, 2962, 3494], 'refold': [2237, 2385], 'about': [2239, 3167], '45%': [2240], 'observed': [2266, 3091, 5061, 5915], 'along': [2267], '(Fig.': [2272, 2299, 2315, 2342, 2370, 2552, 2567, 2612, 2681, 2700, 2714, 2914, 3006, 3178, 3266, 3509, 3545, 3563, 3568, 3676, 3730, 3748, 3769, 3826, 3840, 3852, 3878, 3898, 4788, 4950, 4955], '1).': [2273], 'surprising': [2276], 'find': [2278], 'gradually': [2285, 3265, 3695, 4255, 4992], 'inhibited': [2286, 3696], 'addition': [2289, 2352, 2403, 2625, 2672, 2740, 2920, 3123, 3287, 3397, 3512, 3713, 5921], 'higher': [2295, 2335, 2907, 3660, 3688, 5884], 'μm': [2298, 3508, 3515], '1A),': [2300], 'successfully': [2304], 'depress': [2305, 3786, 3812, 3890], 'dependent': [2313], 'manner': [2314, 3675], '1B).': [2316, 3510, 3677], 'When': [2317, 3245, 5733, 5815], 'samples,': [2324], 'burst': [2329], 'up': [2330], 'nearly': [2332], 'even': [2334], 'self-refolding': [2340, 2396, 3337, 3728], '2A),': [2343], 'changes': [2346, 2617, 2638, 2705, 3777, 4736, 5488], 'activities': [2349, 2620, 5237], 'became': [2355], 'obvious': [2359], 'increase': [2362, 3721, 4249], '2D).': [2371], 'release': [2376], 'additional': [2378, 2410, 2903], 'molecules,': [2381], 'efficiently': [2384, 3666], 'state.': [2389, 5957], 'control,': [2392, 2890, 3085, 3339], 'affected': [2400, 3895], 'suggested': [2407, 2432, 2799, 3284, 3309, 3401, 3905, 4661, 4974, 5006, 5138, 5202, 5225, 5441, 5608, 5998, 6015, 6124], 'released': [2414, 3345, 5019, 5936], 'complexes.': [2428, 2863, 3038, 3349, 5025, 5940], 'DTT-free': [2446, 2795, 2877, 3383, 3562, 3702, 3802, 3874, 4266, 4778, 4949], 'verify': [2461], 'hypothesis,': [2463], 'certain': [2468, 4566], '(Table': [2475, 2535], 'I).': [2476, 5716], 'Play': [2482], 'Central': [2484], 'Role': [2485], 'Inhibition': [2488], 'Effect': [2489], 'Reactivation—Mutational': [2492], 'central': [2499, 4289], 'cysteine(s)': [2500], 'formation.': [2504], 'Besides': [2505], 'N-': [2511], 'considered.': [2525], 'First': [2526], 'I)': [2536, 6109], 'biophysical': [2540], 'CD': [2542], 'little': [2550], 'differences': [2551], '3A),': [2553], 'intrinsic': [2556], 'fluorescence': [2557], 'undistinguishable': [2560], '3B).': [2568], 'tertiary': [2578], 'unaffected': [2585], 'mutation.': [2587], 'ratios': [2602], 'revealed': [2603, 3026], 'quite': [2604, 3594, 5416], 'behaviors': [2606], 'compared': [2608], '2).': [2613], 'can': [2630, 2719, 4033, 5493, 5741, 5823], 'classified': [2632], 'classes,': [2635], 'typical': [2640], 'class': [2644], 'Fig.': [2648, 2723, 2754, 2940, 3120, 3796, 4990, 5003, 5052], '2,': [2649], 'A–C,': [2650], 'respectively.': [2651], 'NCC:BCC:': [2652], 'CSS': [2653], 'NCS:BCC:CSS': [2655, 2896, 2913, 2956, 3822], 'significant': [2658, 2704, 3844], 'activity-enhancing': [2659], '(several': [2661], 'times': [2662], 'enhancing': [2663, 2698], '[PDI]/[CK]': [2665], '2)': [2669], '2A).': [2682, 3731], 'NSS:BCC:CCC,': [2683, 3834, 5175], 'NSC:BCC:CSS,': [2684, 3835, 5176], 'NSS:BCC:CSS,': [2685], 'NSS:BCS:CSS': [2687, 3839, 5180], 'had': [2688, 2897, 4502, 4697, 5395, 6067], 'less': [2689, 2697, 6068], '2B),': [2701], 'detected': [2708], 'NSS:BSC:CSS': [2710, 3003, 3849], 'NSS:': [2712, 5177], 'BSS:CSS': [2713], '2C).': [2715, 3749], 'A': [2716, 2750, 3039, 3385, 3771, 3900, 4484, 6142], 'clearer': [2717], 'result': [2718, 2798, 4594], 'seen': [2721], '2D': [2724, 2755], 'plot': [2727], 'logarithm': [2730], 'recovered': [2733, 3724], 'species.': [2749, 5195], 'close': [2751, 4573], 'inspection': [2752], 'mutations': [2758, 5141], 'Cys-36,': [2760], 'Cys-295,': [2771, 2975], 'non-active': [2773, 4382], 'effectively': [2783], 'eliminate': [2784], 'conditions.': [2796, 3384, 3703, 4269, 6141], 'This': [2797, 2942, 4229, 5412, 6070], 'bonds': [2815, 2851, 2934, 3911, 4589, 5335, 5900, 6022, 6086], 'Existence': [2830], 'Disulfide-linked': [2833], 'Complex': [2834], 'Dimer': [2837], 'Tetramer': [2839], 'Switch': [2840], 'PDI—More': [2842], 'direct': [2843, 3773], 'came': [2856], 'conditions': [2878, 4954, 4963, 5287], 'analyzed': [2881, 3541], 'blotting.': [2887], 'except': [2895], 'one': [2899, 3160, 3235, 3239, 4674, 4767, 5760], 'band,': [2900], 'band': [2904], 'weight': [2909, 2992], '4),': [2915], 'disappeared': [2917], 'linked': [2931], '(see': [2938, 5050], 'Supplemental': [2939, 5051], '8B).': [2941], 'unusual': [2943, 5628, 5993], 'dimers.': [2957], 'For': [2958], 'identified': [2983], 'appearance': [2986, 3391], 'bands.': [2993], 'contrast,': [2995], 'bands': [2998], 'NSS:BSS:CSS': [3005, 3851], '4).': [3007], 'here': [3010], 'confirmed': [3011, 3182, 3359, 4233], 'once': [3023], 'they': [3025], 'Samples': [3067], 'peaks': [3088, 3126, 3134, 3173, 3199], 'prepared': [3098], 'directly': [3100], 'mixing': [3101], 'either': [3109, 4265], '(data': [3114], 'shown).': [3116], '5A,': [3121, 5004], 'appeared': [3135, 3151, 3161, 4773], 'spectrum': [3139], 'assisted': [3145], 'One': [3149], 'void': [3154], 'volume': [3155], '(≥400': [3156], 'kDa),': [3157, 5437], 'another': [3159, 5257], 'mass': [3165], 'kDa.': [3169], '5A)': [3179, 4951], 'contain': [3184], 'SDS-PAGE,': [3192], 'mass,': [3212], '400-kDa': [3214, 3259, 3292, 4766, 4903, 4938, 4987, 5164, 5420], 'assigned': [3218, 4906, 4922], '200-kDa': [3229, 4770, 4889, 4919, 4958, 5016], 'assign': [3233], '(also': [3242], 'see': [3243], '"Discussion").': [3244], 'sample,': [3254], 'amount': [3256, 3333], 'decrease': [3264, 3807, 3830, 5161], '5B).': [3267, 4956], 'Reduced': [3268], 'remainder': [3273], 'contained': [3277, 3305, 3553, 3765], 'destabilized': [3290, 5012], 'peak.': [3293], 'Surprisingly,': [3294], 'existed,': [3301], 'mass.': [3320], 'time,': [3324, 4985], 'refolded': [3328], 'increased': [3330, 4999], 'indicating': [3340], 'interesting': [3387], 'observation': [3388], 'PDI-assisted': [3415, 5219], 'Exhibits': [3419], 'Both': [3420], 'Anti-chaperone': [3421], 'Chaperone': [3423], 'Activity': [3424], 'Its': [3426], 'Assisted': [3427], 'Refolding—It': [3429], 'functioned': [3435], '20.Puig': [3464, 3623], 'Lyles': [3466, 3625, 4335], 'M.M.': [3467, 3626, 4336, 4366, 5543], 'Noiva': [3468, 3627], '269:': [3476, 3635, 3973, 4373], '19128-19135Abstract': [3477, 3636], 'systems,': [3486], 'strong': [3487], 'occurred': [3489, 5098], 'precipitation': [3539, 3552], '6).': [3546], '6A)': [3564], 'DTT-containing': [3566, 3824, 3876, 4268, 4953, 4962], '6B).': [3569], 'Thus': [3570, 4901], 'low': [3577, 5343, 5843], 'resulted': [3579, 3717, 4560, 5971], 'non-covalent': [3581], 'rather': [3583, 5056, 5115], 'consistent': [3595], 'those': [3597, 6120], '21.Song': [3643], 'J.L.': [3644, 3948], 'Quan': [3645, 3949], '328:': [3652, 3956], '841-846Crossref': [3653, 3957], '(28)': [3656, 3960], '(≥1': [3662, 3690, 5886], 'μm),': [3663, 3691, 5846, 5887], 'inhibit': [3667, 3757, 3866], 'concentration-dependent': [3674], 'Thus,': [3678, 4187], 'taken': [3683], 'reversed': [3710], 'slight': [3720, 3829], 'relative': [3726], 'NSS:BSS:CSS,': [3733], 'mutant': [3735], 'cysteines,': [3740], 'abilities': [3751, 3780, 3810, 3882], 'behaved': [3759], 'slightly': [3760, 5186], 'differently': [3761], '7).': [3770], 'comparison': [3774, 5001], 'presented': [3794], '7D.': [3797], 'Compared': [3798], 'buffer,': [3803, 5738, 5821], 'relatively': [3805], 'NCC:BCC:CSS,': [3820], '7A),': [3827], 'NSS:BCC:': [3836], 'CSS,': [3837], '7B),': [3841], 'change': [3845], '7C).': [3853], 'noted': [3858], 'strongly': [3865, 4849, 5224, 6056], '7A–C),': [3879], '7,': [3899], 'B).': [3902], 'contributed': [3916], 'suppression': [3919], 'force.': [3931], 'act': [3937, 4093, 5964], '(21.Song': [3947], '22.Cai': [3963], '24550-24552Abstract': [3974], '23.Quan': [3981], 'Fan': [3983], 'G.B.': [3984], '1995;': [3990, 4304, 4834, 5692], '270:': [3991, 4305, 5601], '17078-17080Abstract': [3992], '(122)': [4000], '24.Yao': [4003], 'Y.C.': [4006], '16:': [4012], '651-658Crossref': [4013], '(112)': [4016], '25.Wang': [4019], 'Methods': [4021], 'Enzymol.': [4022], '348:': [4024], '66-75Crossref': [4025], '(20)': [4028, 4732, 5091], 'exploit': [4034], 'synergy': [4036], 'functions,': [4039], 'especially': [4040], 'reshuffling': [4043], 'needed': [4045], '(3.Freedman': [4052], '26.Bulleid': [4068], '2003;': [4072, 5600], '13:': [4073], '380Abstract': [4074], 'Our': [4083, 4790, 5222], 'general,': [4134], 'force': [4147], '(12.Klappa': [4151], 'Since': [4168, 5279], 'required': [4173, 4394, 4748], 'reactivation,': [4176, 5980], 'will': [4184], 'happen.': [4186], 'protection': [4189], 'attributed': [4198, 4216], 'interactions,': [4206], 'uncompleted': [4219, 5986], 'site-directed': [4235], 'mutagenesis': [4236], '(Figs.': [4237], '7),': [4240], 'depressed': [4256], 'cysteine,': [4273], 'Cys-380,': [4276], 'playing': [4287], '(27.Laboissière': [4295], 'M.C.A.': [4296], 'Sturley': [4297], 'S.L.': [4298], 'Raines': [4299], 'R.T.': [4300], '28006-28009Abstract': [4306], '(186)': [4314], '28.LaMantia': [4317], 'M.L.': [4318], 'Lennarz': [4319], 'Cell.': [4321], '1993;': [4322], '74:': [4323], '899-908Abstract': [4324], '(185)': [4330], '29.Walker': [4333], '35:': [4341, 5574], '1972-1980Crossref': [4342], '(142)': [4345], 'considered': [4354], 'whole': [4360], '(30.Lyles': [4365], '30946-30952Abstract': [4374], 'unlikely': [4420], 'participate': [4422], 'Cys-380': [4480], 'required.': [4483], 'possible': [4485], 'explanation': [4486], 'specificity,': [4499], 'pancreas-specific': [4506], '(31.Klappa': [4508], 'Langenbuch': [4512], 'Lan': [4514], 'M.S.': [4515], 'Robinson': [4516], 'G.K.': [4517], '354:': [4523], '553-559Crossref': [4524], '(34)': [4527], '32.Ruddock': [4530], '2000;': [4538], '9:': [4539], '758-764Crossref': [4540], '(46)': [4543], 'recognition': [4548], 'made': [4549], 'directional,': [4557], 'exposure': [4563], 'conformationally': [4572], 'Cys-380.': [4579], 'participation': [4581], 'noteworthy': [4606], 'recent': [4609], 'near': [4616, 4667], 'sites': [4679], 'like': [4683], 'widely': [4688, 5502], 'accepted': [4689], 'dimer,': [4694, 5290], 'mixture': [4703], '7.5': [4713], '(33.Yu': [4718, 5077], 'X.C.': [4719, 5078], 'Biochim.': [4724, 5083], 'Biophys.': [4725, 5084], 'Acta.': [4726, 5085], '1207:': [4728, 5087], '109-113Crossref': [4729, 5088], 'oligomer,': [4740], 'however,': [4741], 'never': [4743], 'function': [4752, 5152], 'research,': [4760], 'conditions,': [4779], '5).': [4789], 'work': [4792, 5637, 5718, 6130], 'monomeric': [4796], 'rapidly': [4799], 'form': [4800, 5742, 5795], 'intermediates': [4804], 'dimerization': [4814], '(34.Wang': [4826], 'Z.F.': [4827, 5685], 'Biochimie': [4832, 5690], '(Paris).': [4833, 5691], '77:': [4835, 5693], '953-956Crossref': [4836, 5694], '(27)': [4839, 5697], 'GroEL': [4847], 'bind': [4850, 5824], '(14.Li': [4857, 5644], 'observations,': [4883], '400-': [4887, 5014], 'intermediate.': [4900], 'PDIs': [4912], 'CKs,': [4916], 'conformational': [4934], 'state': [4935, 5808], 'tetramer.': [4981, 5351], '5B': [4991], 'decreased,': [4993], 'cross-linked': [5021], 'Further': [5026], 'obtained': [5033], '8).': [5053], 'Although': [5054], 'behavior': [5058], 'mutants,': [5064], 'samples.': [5071], 'disulfides': [5110], 'dimers': [5113], 'oligomerization': [5118, 5490, 6152], 'interfaces.': [5119], 'NCC:': [5123], 'BCC:CSS': [5124], 'almost': [5129], 'Cys': [5143, 5364], 'affect': [5150], 'profiles': [5167], 'BCC:CSS,': [5178], 'decreased': [5187], 'stability': [5188, 5344], 'several': [5246], 'important': [5247], 'issues': [5248], 'remain': [5250], 'answered.': [5253], '(i)': [5254], 'Is': [5255, 5307], 'there': [5256], 'inverse': [5258, 5293], 'requiring': [5272], 'bonds?': [5278], 'component': [5282], 'such': [5291, 5353, 5506, 5512, 5610], 'exist': [5296], 'distinguished': [5302], 'research.': [5305, 5425], '(ii)': [5306], 'CK?': [5318], 'introduction,': [5323], 'accumulate': [5329], 'achieved': [5358], 'Primm': [5370], '(≥500': [5401], 'ADH': [5406], 'PDI-ADH': [5413, 5434], 'Tetrameric': [5426], '(iii)': [5479], 'take': [5494], 'place': [5495], 'vivo': [5497, 6140], 'not.': [5499], 'Nevertheless,': [5500], 'examples': [5504], 'chaperones,': [5511], 'heat': [5515], 'shock': [5516], '(Hsp)': [5518], '(35.Giese': [5519], 'K.C.': [5520], 'Vierling': [5521], '277:': [5527], '46310-46318Abstract': [5528], '(133)': [5536], 'Hsp90': [5539], '(36.Chadli': [5540], 'Ladjimi': [5542], 'Baulieu': [5544], 'E.E.': [5545], 'Catelli': [5546], 'M.G.': [5547], '274:': [5552], '4133-4139Abstract': [5553], '(43)': [5561], '(37.Wearsch': [5568], 'P.A.': [5569], 'Nicchitta': [5570], 'C.V.': [5571], '16760-16769Crossref': [5575], '(73)': [5578], '38.Jorgensen': [5581], 'C.S.': [5582], 'Ryder': [5583], 'L.R.': [5584], 'Steino': [5585], 'Hojrup': [5587], 'Hansen': [5589], 'Beyer': [5591], 'N.H.': [5592, 5594], 'Heegaard': [5593], 'Houen': [5595], 'G.': [5596], '4140-4148Crossref': [5602], '(52)': [5605], 'experimental': [5629], '34.Wang': [5684], '(Scheme': [5715, 6108], 'Previous': [5717], '(N)': [5725], 'dissociated': [5726], 'monomers': [5728, 5740], '(U)': [5729], 'denaturation': [5731], '(kdena).': [5732], '(U2)': [5747], 'short': [5751], 'time': [5752], '(kdim).': [5753], 'fates': [5755], 'U2': [5757, 5776, 5849, 5902, 5906, 5942], 'found;': [5759], 'insoluble': [5766, 5863], '(kself),': [5771], 'other,': [5775], 'undergoes': [5777, 5943], 'fast': [5779, 5945], 'phase': [5780, 5800, 5946, 5950], '(k1)': [5781], 'partially': [5784, 5983], 'N2′.': [5787], 'N2′': [5789], 'refolds': [5790, 5804, 5953], 'native-like': [5794], 'N2': [5796], 'slow': [5799, 5812, 5949], '(k2)': [5801], 'finally': [5803, 5952], 'adjustment': [5813], '(ks-adju).': [5814], 'present': [5818], 'U2,': [5829], 'forms': [5832, 5890, 6162], '(U2P)': [5836], '(kb).': [5837], 'If': [5838, 5879], '(0.2': [5845], 'excessive': [5848], 'binds': [5850], 'U2P': [5852, 5888], 'interaction,': [5855], 'aggregates.': [5864], 'way': [5867], 'exhibits': [5875], '(ka-chap).': [5878], '(PU2U2P,': [5895], 'kb1).': [5896], 'prevent': [5905], 'reactivation.': [5918], 'With': [5919], '(U2),': [5929], 'conclusion,': [5959], 'aggregation,': [5969], 'function,': [5975, 5988], 'arose': [5982], 'interrelated': [6007], 'activities.': [6042], 'system': [6045], '(400': [6050], 'protected': [6057], 'stability.': [6069], 'short-lived': [6077], 'potential': [6094], 'hidden': [6095], 'dimer.': [6100], 'consistence': [6103], 'findings': [6113], 'well': [6118, 6137], 'systems': [6135], 'investigation': [6144], 'elucidate': [6166], 'meets': [6169], 'requirements': [6172], 'We': [6176], 'thank': [6177], '(Capital': [6181], 'China)': [6187], 'kindly': [6189], 'providing': [6190], 'pBV220-PDI.': [6194], 'Download': [6195], '.pdf': [6196], '(.08': [6197], 'MB)': [6198], 'Help': [6199], 'pdf': [6201], 'files': [6202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083552214', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-24T14:36:27.602703', 'created_date': '2016-06-24'}