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'https://openalex.org/W1947939452', 'https://openalex.org/W1821778427'], 'abstract_inverted_index': {'Intravenous': [0], 'treatment': [1], 'of': [2, 28, 42, 73, 85, 102, 110, 178, 213, 233, 240, 257], 'male': [3], 'rats': [4], 'with': [5], 'recombinant': [6, 139], 'human': [7, 129, 140], 'interleukin-6': [8], '(rhIL6)': [9], 'at': [10], '50,': [11], '100': [12], 'and': [13, 19, 124, 138, 166, 189, 216], '200μg/kg': [14], '(corresponding': [15], 'to': [16, 34, 40, 48, 63, 100, 118, 134, 149, 230, 243, 247, 254], '4,': [17], '8': [18], '16': [20], '×': [21, 136, 151], '104': [22], 'U/animal,': [23], 'respectively)': [24], 'reduced': [25, 98], 'the': [26, 71, 86, 176, 211, 219, 241, 255], 'activities': [27, 72, 183], 'hepatic': [29, 168], 'microsomal': [30, 169, 181], 'cytochrome': [31, 87], 'P450-dependent': [32, 75], 'monoxygenases': [33], 'varying': [35], 'degrees.': [36], 'Ethylmorphine-N-demethylase/': [37], 'activity': [38, 59], 'fell': [39], '53%': [41], 'control': [43, 103], 'values,': [44], 'an': [45, 231], 'effect': [46, 69], 'similar': [47], 'that': [49, 210], 'induced': [50], 'by': [51, 94, 116, 122, 126, 187, 191], '2.5': [52], 'μg/kg': [53, 147], 'Escherichia': [54], 'coli': [55], 'lipopolysaccharide': [56], '(LPS).': [57], 'Ethoxycoumarin-O-deethylase': [58], 'was': [60, 92, 114, 195], 'also': [61], 'sensitive': [62], 'inhibition,': [64], 'whereas': [65, 96], 'IL6': [66, 95, 123, 172, 234, 244], 'had': [67], 'little': [68, 185], 'on': [70, 218], 'other': [74], 'enzymes,': [76], 'including': [77], 'ethoxyresorufin-O-deethylase.': [78], 'Pentoxyresorufin': [79], 'dealkylase': [80], 'activity,': [81], 'which': [82], 'is': [83], 'representative': [84], 'P450': [88], 'IIB': [89], '12': [90], 'subfamily,': [91], 'unaffected': [93, 190], 'LPS': [97, 158, 188], 'it': [99], '33.7%': [101], 'values.': [104], 'Another': [105], 'hepatocyte-related': [106], 'parameter,': [107], 'serum': [108, 163], 'concentration': [109], 'α1-acid': [111], 'glycoprotein': [112], '(AGP),': [113], 'increased': [115], 'up': [117], '3.5-fold': [119], 'over': [120], 'baseline': [121], '10-fold': [125], 'LPS.': [127], 'Recombinant': [128], 'interleukin-1β': [130], '(rhIL1β)': [131], '10μg/kg,': [132], 'corresponding': [133, 148], '5': [135], '104U/rat)': [137, 152], 'tumor': [141], 'necrosis': [142], 'factor': [143], 'α': [144], '(rhTNF)': [145], '(150': [146], '24': [150], 'were': [153, 184], 'both': [154], 'as': [155, 157], 'potent': [156, 197], '(2.5': [159], 'μg/kg)': [160], 'in': [161, 224, 235], 'increasing': [162], 'AGP': [164], 'levels': [165], 'reducing': [167], 'monoxygenase': [170], 'activities.': [171], 'did': [173], 'not': [174, 246], 'potentiate': [175], 'effects': [177, 212], 'rhIL1β.': [179], 'Hepatic': [180], 'glucuronyltransferase': [182], 'affected': [186], 'rhIL6.': [192], 'Finally,': [193], 'rhIL6': [194], 'more': [196], 'after': [198, 202], 'i.p.': [199], 'injection': [200], 'than': [201], 'i.v.': [203], 'or': [204, 249], 's.c.': [205], 'injection.': [206], 'These': [207], 'results': [208], 'suggest': [209], 'LPS,': [214], 'TNF': [215, 250], 'IL1': [217, 248], 'mixed': [220], 'function': [221], 'oxidase': [222], 'system': [223], 'vivo': [225], 'may': [226, 251], 'be': [227, 252], 'due': [228, 253], 'partly': [229], 'induction': [232], 'vivo.': [236], 'The': [237], 'different': [238], 'sensitivities': [239], 'enzymes': [242], 'but': [245], 'involvement': [256], 'two': [258], 'distinct': [259], 'mechanisms.': [260]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083492764', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-31T21:55:13.534710', 'created_date': '2016-06-24'}