Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2083249145', 'doi': 'https://doi.org/10.1073/pnas.1006760107', 'title': 'Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding', 'display_name': 'Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding', 'publication_year': 2010, 'publication_date': '2010-10-04', 'ids': {'openalex': 'https://openalex.org/W2083249145', 'doi': 'https://doi.org/10.1073/pnas.1006760107', 'mag': '2083249145', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20921368', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2955104'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1006760107', 'pdf_url': 'https://www.pnas.org/content/pnas/107/41/17586.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.pnas.org/content/pnas/107/41/17586.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101069184', 'display_name': 'Apratim Dhar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Apratim Dhar', 'raw_affiliation_strings': ['Department of Chemistry, University of Illinois, Urbana , IL 61801, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Illinois, Urbana , IL 61801, USA', 'institution_ids': ['https://openalex.org/I157725225']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070626230', 'display_name': 'Antonios Samiotakis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I44461941', 'display_name': 'University of Houston', 'ror': 'https://ror.org/048sx0r50', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44461941']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Antonios Samiotakis', 'raw_affiliation_strings': ['Department of Physics, University of Houston, Houston, TX 77204; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Physics, University of Houston, Houston, TX 77204; and', 'institution_ids': ['https://openalex.org/I44461941']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022046851', 'display_name': 'Simon Ebbinghaus', 'orcid': 'https://orcid.org/0000-0001-9309-1279'}, 'institutions': [{'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Simon Ebbinghaus', 'raw_affiliation_strings': ['Department of Chemistry, University of Illinois, Urbana, IL 61801;'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Illinois, Urbana, IL 61801;', 'institution_ids': ['https://openalex.org/I157725225']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007496801', 'display_name': 'Lea Nienhaus', 'orcid': 'https://orcid.org/0000-0003-1412-412X'}, 'institutions': [{'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lea Nienhaus', 'raw_affiliation_strings': ['Department of Chemistry, University of Illinois, Urbana, IL 61801;'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Illinois, Urbana, IL 61801;', 'institution_ids': ['https://openalex.org/I157725225']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067425197', 'display_name': 'Dirar Homouz', 'orcid': 'https://orcid.org/0000-0002-8859-0265'}, 'institutions': [{'id': 'https://openalex.org/I44461941', 'display_name': 'University of Houston', 'ror': 'https://ror.org/048sx0r50', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44461941']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dirar Homouz', 'raw_affiliation_strings': ['Department of Physics, University of Houston, Houston, TX 77204; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Physics, University of Houston, Houston, TX 77204; and', 'institution_ids': ['https://openalex.org/I44461941']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009810193', 'display_name': 'Martin Gruebele', 'orcid': 'https://orcid.org/0000-0001-9291-8123'}, 'institutions': [{'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Martin Gruebele', 'raw_affiliation_strings': ['Beckman Institute for Advanced Science and Technology', 'Department of Chemistry, University of Illinois, Urbana, IL 61801;', 'Department of Physics and Center for Biophysics and Computational Biology, University of Illinois, Urbana, IL 61801'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Illinois, Urbana, IL 61801;', 'institution_ids': ['https://openalex.org/I157725225']}, {'raw_affiliation_string': 'Department of Physics and Center for Biophysics and Computational Biology, University of Illinois, Urbana, IL 61801', 'institution_ids': ['https://openalex.org/I157725225']}, {'raw_affiliation_string': 'Beckman Institute for Advanced Science and Technology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5042375063', 'display_name': 'Margaret S. Cheung', 'orcid': 'https://orcid.org/0000-0001-9235-7661'}, 'institutions': [{'id': 'https://openalex.org/I44461941', 'display_name': 'University of Houston', 'ror': 'https://ror.org/048sx0r50', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44461941']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Margaret S. Cheung', 'raw_affiliation_strings': ['Department of Physics, University of Houston, Houston, TX 77204; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Physics, University of Houston, Houston, TX 77204; and', 'institution_ids': ['https://openalex.org/I44461941']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 9.996, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 308, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '107', 'issue': '41', 'first_page': '17586', 'last_page': '17591'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phosphoglycerate-kinase', 'display_name': 'Phosphoglycerate kinase', 'score': 0.91038287}, {'id': 'https://openalex.org/keywords/macromolecular-crowding', 'display_name': 'Macromolecular Crowding', 'score': 0.84059393}, {'id': 'https://openalex.org/keywords/ficoll', 'display_name': 'Ficoll', 'score': 0.7352531}, {'id': 'https://openalex.org/keywords/folding', 'display_name': 'Folding (DSP implementation)', 'score': 0.6393909}], 'concepts': [{'id': 'https://openalex.org/C155911427', 'wikidata': 'https://www.wikidata.org/wiki/Q24772193', 'display_name': 'Phosphoglycerate kinase', 'level': 3, 'score': 0.91038287}, {'id': 'https://openalex.org/C181990884', 'wikidata': 'https://www.wikidata.org/wiki/Q11396092', 'display_name': 'Macromolecular crowding', 'level': 3, 'score': 0.84059393}, {'id': 'https://openalex.org/C5362183', 'wikidata': 'https://www.wikidata.org/wiki/Q410200', 'display_name': 'Ficoll', 'level': 4, 'score': 0.7352531}, {'id': 'https://openalex.org/C2776545253', 'wikidata': 'https://www.wikidata.org/wiki/Q5464292', 'display_name': 'Folding (DSP implementation)', 'level': 2, 'score': 0.6393909}, {'id': 'https://openalex.org/C204328495', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein folding', 'level': 2, 'score': 0.55281365}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.50302905}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48664364}, {'id': 'https://openalex.org/C19472624', 'wikidata': 'https://www.wikidata.org/wiki/Q583851', 'display_name': 'Native state', 'level': 2, 'score': 0.47687227}, {'id': 'https://openalex.org/C8010536', 'wikidata': 'https://www.wikidata.org/wiki/Q160398', 'display_name': 'Crystallography', 'level': 1, 'score': 0.44901133}, {'id': 'https://openalex.org/C2776029896', 'wikidata': 'https://www.wikidata.org/wiki/Q3935810', 'display_name': 'Relaxation (psychology)', 'level': 2, 'score': 0.44266522}, {'id': 'https://openalex.org/C204389451', 'wikidata': 'https://www.wikidata.org/wiki/Q178593', 'display_name': 'Macromolecule', 'level': 2, 'score': 0.38032418}, {'id': 'https://openalex.org/C159467904', 'wikidata': 'https://www.wikidata.org/wiki/Q2001702', 'display_name': 'Chemical physics', 'level': 1, 'score': 0.37208402}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.193613}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19060722}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17781812}, {'id': 'https://openalex.org/C137061746', 'wikidata': 'https://www.wikidata.org/wiki/Q736033', 'display_name': 'Peripheral blood mononuclear cell', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C119599485', 'wikidata': 'https://www.wikidata.org/wiki/Q43035', 'display_name': 'Electrical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008956', 'descriptor_name': 'Models, Chemical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010735', 'descriptor_name': 'Phosphoglycerate Kinase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003198', 'descriptor_name': 'Computer Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005362', 'descriptor_name': 'Ficoll', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005362', 'descriptor_name': 'Ficoll', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D031541', 'descriptor_name': 'Fluorescence Resonance Energy Transfer', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010735', 'descriptor_name': 'Phosphoglycerate Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010735', 'descriptor_name': 'Phosphoglycerate Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013696', 'descriptor_name': 'Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014783', 'descriptor_name': 'Viscosity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015003', 'descriptor_name': 'Yeasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1006760107', 'pdf_url': 'https://www.pnas.org/content/pnas/107/41/17586.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2955104', 'pdf_url': 'https://europepmc.org/articles/pmc2955104?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955104', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20921368', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1006760107', 'pdf_url': 'https://www.pnas.org/content/pnas/107/41/17586.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1549063714', 'https://openalex.org/W1550452265', 'https://openalex.org/W1968827368', 'https://openalex.org/W1973897761', 'https://openalex.org/W1976051941', 'https://openalex.org/W1976164436', 'https://openalex.org/W1987265916', 'https://openalex.org/W1995838356', 'https://openalex.org/W1997848056', 'https://openalex.org/W2002653106', 'https://openalex.org/W2016081971', 'https://openalex.org/W2019323543', 'https://openalex.org/W2025017841', 'https://openalex.org/W2029750840', 'https://openalex.org/W2030866185', 'https://openalex.org/W2034534281', 'https://openalex.org/W2036911691', 'https://openalex.org/W2041804296', 'https://openalex.org/W2044448248', 'https://openalex.org/W2044772240', 'https://openalex.org/W2054776602', 'https://openalex.org/W2060222676', 'https://openalex.org/W2069344198', 'https://openalex.org/W2072516324', 'https://openalex.org/W2084572582', 'https://openalex.org/W2084642783', 'https://openalex.org/W2085519055', 'https://openalex.org/W2090890923', 'https://openalex.org/W2091967731', 'https://openalex.org/W2096759266', 'https://openalex.org/W2096795069', 'https://openalex.org/W2103837357', 'https://openalex.org/W2122345838', 'https://openalex.org/W2132881646', 'https://openalex.org/W2147700328', 'https://openalex.org/W2149744037', 'https://openalex.org/W2165360511', 'https://openalex.org/W2166905169', 'https://openalex.org/W2169113904', 'https://openalex.org/W2951282694', 'https://openalex.org/W3104620934'], 'related_works': ['https://openalex.org/W4380577438', 'https://openalex.org/W4319215952', 'https://openalex.org/W3000245460', 'https://openalex.org/W2972496797', 'https://openalex.org/W2040916796', 'https://openalex.org/W2037658617', 'https://openalex.org/W2003848603', 'https://openalex.org/W1994889800', 'https://openalex.org/W1988517764', 'https://openalex.org/W1227884103'], 'abstract_inverted_index': {'We': [0, 143, 156], 'combine': [1], 'experiment': [2], 'and': [3, 16, 56, 68, 101, 120, 167], 'computer': [4], 'simulation': [5], 'to': [6, 93, 109, 191], 'show': [7], 'how': [8, 98], 'macromolecular': [9], 'crowding': [10, 38, 154], 'dramatically': [11], 'affects': [12], 'the': [13, 35, 94, 99, 118, 133, 139, 179, 185, 192, 196], 'structure,': [14], 'function,': [15], 'folding': [17, 160, 181, 198], 'landscape': [18], 'of': [19, 29, 37, 97, 105, 148, 153, 202], 'phosphoglycerate': [20], 'kinase': [21], '(PGK).': [22], 'Fluorescence': [23], 'labeling': [24], 'shows': [25], 'that': [26, 131], 'compact': [27, 48], 'states': [28], 'yeast': [30], 'PGK': [31, 67, 70, 106, 149], 'are': [32, 71, 123], 'populated': [33], 'as': [34, 150], 'amount': [36], 'agents': [39], '(Ficoll': [40], '70)': [41], 'increases.': [42], 'Coarse-grained': [43], 'molecular': [44], 'simulations': [45], 'reveal': [46], 'three': [47], 'ensembles:': [49], 'C': [50], '(crystal': [51], 'structure),': [52], 'CC': [53], '(collapsed': [54], 'crystal),': [55], 'Sph': [57], '(spherical': [58], 'compact).': [59], 'With': [60], 'an': [61, 171], 'adjustment': [62], 'for': [63, 175], 'viscosity,': [64], 'crowded': [65, 129], 'wild-type': [66], 'fluorescent': [69], 'about': [72], '15': [73], 'times': [74], 'or': [75], 'more': [76], 'active': [77], 'in': [78, 83, 126, 134], '200': [79], 'mg/ml': [80], 'Ficoll': [81, 164], 'than': [82, 113], 'aqueous': [84], 'solution.': [85], 'Our': [86], 'results': [87], 'suggest': [88], 'a': [89, 115, 151, 158], 'previously': [90], 'undescribed': [91], 'solution': [92], 'classic': [95], 'problem': [96], 'ADP': [100, 119], 'diphosphoglycerate': [102], 'binding': [103], 'sites': [104, 122], 'come': [107], 'together': [108], 'make': [110], 'ATP:': [111], 'Rather': [112], 'undergoing': [114], 'hinge': [116], 'motion,': [117], 'substrate': [121], 'already': [124], 'located': [125], 'proximity': [127], 'under': [128, 137], 'conditions': [130, 136], 'mimic': [132], 'vivo': [135], 'which': [138], 'enzyme': [140], 'actually': [141], 'operates.': [142], 'also': [144], 'examine': [145], 'T-jump': [146], 'unfolding': [147], 'function': [152], 'experimentally.': [155], 'uncover': [157], 'nonmonotonic': [159], 'relaxation': [161], 'time': [162], 'vs.': [163], 'concentration.': [165], 'Theory': [166], 'modeling': [168], 'explain': [169], 'why': [170], 'optimum': [172], 'concentration': [173], 'exists': [174], 'fastest': [176], 'folding.': [177], 'Below': [178], 'optimum,': [180, 197], 'slows': [182, 199], 'down': [183, 200], 'because': [184, 201], 'unfolded': [186], 'state': [187], 'is': [188], 'stabilized': [189], 'relative': [190], 'transition': [193], 'state.': [194], 'Above': [195], 'increased': [203], 'viscosity.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083249145', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 24}, {'year': 2016, 'cited_by_count': 29}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 33}, {'year': 2013, 'cited_by_count': 29}, {'year': 2012, 'cited_by_count': 22}], 'updated_date': '2024-12-28T04:52:43.260415', 'created_date': '2016-06-24'}