Publication Information

{'id': 'https://openalex.org/W2083124842', 'doi': 'https://doi.org/10.2147/btt.s29965', 'title': 'Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents', 'display_name': 'Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents', 'publication_year': 2013, 'publication_date': '2013-02-01', 'ids': {'openalex': 'https://openalex.org/W2083124842', 'doi': 'https://doi.org/10.2147/btt.s29965', 'mag': '2083124842', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23459471', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3584656'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/btt.s29965', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=15286', 'source': {'id': 'https://openalex.org/S177732258', 'display_name': 'Biologics', 'issn_l': '1177-5475', 'issn': ['1177-5475', '1177-5491'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=15286', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016217164', 'display_name': 'Paul V. Licciardi', 'orcid': 'https://orcid.org/0000-0001-6086-6285'}, 'institutions': [{'id': 'https://openalex.org/I4210150290', 'display_name': "Murdoch Children's Research Institute", 'ror': 'https://ror.org/048fyec77', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210150290']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Paul Licciardi', 'raw_affiliation_strings': ["Murdoch Children's Research Institute"], 'affiliations': [{'raw_affiliation_string': "Murdoch Children's Research Institute", 'institution_ids': ['https://openalex.org/I4210150290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106048549', 'display_name': 'Ververis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210163178', 'display_name': 'Alfred Health', 'ror': 'https://ror.org/04scfb908', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210163178']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'None Ververis', 'raw_affiliation_strings': ['Epigenomic Medicine, Alfred Medical Research and Education Precinct, Melbourne, VIC, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Epigenomic Medicine, Alfred Medical Research and Education Precinct, Melbourne, VIC, Australia.', 'institution_ids': ['https://openalex.org/I4210163178']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108091081', 'display_name': 'Hiong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210163178', 'display_name': 'Alfred Health', 'ror': 'https://ror.org/04scfb908', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210163178']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'None Hiong', 'raw_affiliation_strings': ['Alfred Health'], 'affiliations': [{'raw_affiliation_string': 'Alfred Health', 'institution_ids': ['https://openalex.org/I4210163178']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078535728', 'display_name': 'Tom C. Karagiannis', 'orcid': 'https://orcid.org/0000-0002-9967-1546'}, 'institutions': [{'id': 'https://openalex.org/I4210163178', 'display_name': 'Alfred Health', 'ror': 'https://ror.org/04scfb908', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210163178']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'None Karagiannis', 'raw_affiliation_strings': ['Alfred Health'], 'affiliations': [{'raw_affiliation_string': 'Alfred Health', 'institution_ids': ['https://openalex.org/I4210163178']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2320, 'currency': 'USD', 'value_usd': 2320, 'provenance': 'doaj'}, 'apc_paid': {'value': 2320, 'currency': 'USD', 'value_usd': 2320, 'provenance': 'doaj'}, 'fwci': 14.829, 'has_fulltext': False, 'cited_by_count': 270, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': None, 'issue': None, 'first_page': '47', 'last_page': '47'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/histone-deacetylase-inhibitor', 'display_name': 'Histone deacetylase inhibitor', 'score': 0.42320728}], 'concepts': [{'id': 'https://openalex.org/C2778305200', 'wikidata': 'https://www.wikidata.org/wiki/Q174378', 'display_name': 'Histone deacetylase', 'level': 4, 'score': 0.7798574}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.54615057}, {'id': 'https://openalex.org/C2776202225', 'wikidata': 'https://www.wikidata.org/wiki/Q3569101', 'display_name': 'Histone deacetylase inhibitor', 'level': 5, 'score': 0.42320728}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.41982356}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40252674}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36826837}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3415482}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10025644}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/btt.s29965', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=15286', 'source': {'id': 'https://openalex.org/S177732258', 'display_name': 'Biologics', 'issn_l': '1177-5475', 'issn': ['1177-5475', '1177-5491'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/59ef244e4cd64ca2bf96ff421a175c18', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3584656', 'pdf_url': 'https://europepmc.org/articles/pmc3584656?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.dovepress.com/histone-deacetylase-inhibitors-hdacis-multitargeted-anticancer-agents-peer-reviewed-article-BTT', 'pdf_url': 'https://www.dovepress.com/article_sign_file.php?article_id=12289', 'source': {'id': 'https://openalex.org/S4306401012', 'display_name': 'Dove Medical Press (Taylor and Francis Group)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584656', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23459471', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/btt.s29965', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=15286', 'source': {'id': 'https://openalex.org/S177732258', 'display_name': 'Biologics', 'issn_l': '1177-5475', 'issn': ['1177-5475', '1177-5491'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 164, 'referenced_works': ['https://openalex.org/W12965686', 'https://openalex.org/W1513102126', 'https://openalex.org/W1519763364', 'https://openalex.org/W154212680', 'https://openalex.org/W154704142', 'https://openalex.org/W1567485746', 'https://openalex.org/W1587632330', 'https://openalex.org/W1587947784', 'https://openalex.org/W1626483287', 'https://openalex.org/W1910848366', 'https://openalex.org/W1963919702', 'https://openalex.org/W1967018540', 'https://openalex.org/W1968489542', 'https://openalex.org/W1968677790', 'https://openalex.org/W1968972540', 'https://openalex.org/W1969249015', 'https://openalex.org/W1969323007', 'https://openalex.org/W1970772467', 'https://openalex.org/W1971557910', 'https://openalex.org/W1973262157', 'https://openalex.org/W1973962086', 'https://openalex.org/W1975692560', 'https://openalex.org/W1976298557', 'https://openalex.org/W1977454730', 'https://openalex.org/W1981301540', 'https://openalex.org/W1982486040', 'https://openalex.org/W1985030042', 'https://openalex.org/W1987333228', 'https://openalex.org/W1988284872', 'https://openalex.org/W1989696433', 'https://openalex.org/W1989811175', 'https://openalex.org/W1990011854', 'https://openalex.org/W1991660464', 'https://openalex.org/W1991995900', 'https://openalex.org/W1992857281', 'https://openalex.org/W1993510744', 'https://openalex.org/W1996809397', 'https://openalex.org/W1998957807', 'https://openalex.org/W2002919375', 'https://openalex.org/W2003535009', 'https://openalex.org/W2004800182', 'https://openalex.org/W2005471059', 'https://openalex.org/W2006866162', 'https://openalex.org/W2010710786', 'https://openalex.org/W2013571070', 'https://openalex.org/W2014941193', 'https://openalex.org/W2017204495', 'https://openalex.org/W2019465043', 'https://openalex.org/W2021418277', 'https://openalex.org/W2024202249', 'https://openalex.org/W2026549010', 'https://openalex.org/W2026694991', 'https://openalex.org/W2029273249', 'https://openalex.org/W2030928908', 'https://openalex.org/W2031046263', 'https://openalex.org/W2033176001', 'https://openalex.org/W2033747485', 'https://openalex.org/W2033858594', 'https://openalex.org/W2044570206', 'https://openalex.org/W2049365130', 'https://openalex.org/W2049763628', 'https://openalex.org/W2049961455', 'https://openalex.org/W2050339689', 'https://openalex.org/W2056827933', 'https://openalex.org/W2057561198', 'https://openalex.org/W2059024085', 'https://openalex.org/W2059172839', 'https://openalex.org/W2063528655', 'https://openalex.org/W2063819389', 'https://openalex.org/W2064117044', 'https://openalex.org/W2064602574', 'https://openalex.org/W2064799896', 'https://openalex.org/W2068774036', 'https://openalex.org/W2070433411', 'https://openalex.org/W2071115015', 'https://openalex.org/W2071831973', 'https://openalex.org/W2071888464', 'https://openalex.org/W2072375912', 'https://openalex.org/W2072669480', 'https://openalex.org/W2073184728', 'https://openalex.org/W2073189570', 'https://openalex.org/W2073978750', 'https://openalex.org/W2074096371', 'https://openalex.org/W2078220845', 'https://openalex.org/W2079003739', 'https://openalex.org/W2079102916', 'https://openalex.org/W2080758856', 'https://openalex.org/W2081159709', 'https://openalex.org/W2081705690', 'https://openalex.org/W2085207531', 'https://openalex.org/W2086172979', 'https://openalex.org/W2087966689', 'https://openalex.org/W2088233020', 'https://openalex.org/W2089077371', 'https://openalex.org/W2090906911', 'https://openalex.org/W2091041925', 'https://openalex.org/W2091956563', 'https://openalex.org/W2092301324', 'https://openalex.org/W2092722802', 'https://openalex.org/W2095237894', 'https://openalex.org/W2096083625', 'https://openalex.org/W2096442515', 'https://openalex.org/W2097084183', 'https://openalex.org/W2097856894', 'https://openalex.org/W2099803844', 'https://openalex.org/W2101127235', 'https://openalex.org/W2102650381', 'https://openalex.org/W2102884982', 'https://openalex.org/W2103309832', 'https://openalex.org/W2103789449', 'https://openalex.org/W2105095164', 'https://openalex.org/W2105318626', 'https://openalex.org/W2105439521', 'https://openalex.org/W2106357158', 'https://openalex.org/W2107733280', 'https://openalex.org/W2108017291', 'https://openalex.org/W2110787699', 'https://openalex.org/W2110894784', 'https://openalex.org/W2110957729', 'https://openalex.org/W2112057120', 'https://openalex.org/W2112351720', 'https://openalex.org/W2113303160', 'https://openalex.org/W2115354390', 'https://openalex.org/W2116242474', 'https://openalex.org/W2119478924', 'https://openalex.org/W2122574122', 'https://openalex.org/W2123324115', 'https://openalex.org/W2125751034', 'https://openalex.org/W2127275456', 'https://openalex.org/W2129522972', 'https://openalex.org/W2131438908', 'https://openalex.org/W2133653334', 'https://openalex.org/W2134087142', 'https://openalex.org/W2135619784', 'https://openalex.org/W2140089594', 'https://openalex.org/W2140523553', 'https://openalex.org/W2140832593', 'https://openalex.org/W2141040456', 'https://openalex.org/W2141882676', 'https://openalex.org/W2143658931', 'https://openalex.org/W2146027649', 'https://openalex.org/W2151071075', 'https://openalex.org/W2155725346', 'https://openalex.org/W2156247910', 'https://openalex.org/W2156712995', 'https://openalex.org/W2160641961', 'https://openalex.org/W2164380111', 'https://openalex.org/W2164382188', 'https://openalex.org/W2164713773', 'https://openalex.org/W2167118090', 'https://openalex.org/W2168434477', 'https://openalex.org/W2168448928', 'https://openalex.org/W2170925020', 'https://openalex.org/W2171185186', 'https://openalex.org/W2176276', 'https://openalex.org/W2312208839', 'https://openalex.org/W2322598975', 'https://openalex.org/W2462972751', 'https://openalex.org/W2529676265', 'https://openalex.org/W2591548310', 'https://openalex.org/W4233036449', 'https://openalex.org/W4249469332', 'https://openalex.org/W4376490835', 'https://openalex.org/W67322295'], 'related_works': ['https://openalex.org/W4362426498', 'https://openalex.org/W4362418352', 'https://openalex.org/W4361880833', 'https://openalex.org/W2908166538', 'https://openalex.org/W2901499330', 'https://openalex.org/W2074781740', 'https://openalex.org/W2051615431', 'https://openalex.org/W2030301626', 'https://openalex.org/W2029175848', 'https://openalex.org/W1989395477'], 'abstract_inverted_index': {'Histone': [0], 'deacetylase': [1], '(HDAC)': [2], 'inhibitors': [3, 20, 63, 88, 111, 132, 182, 200, 211, 249, 264, 281], 'are': [4, 129, 188, 212, 251], 'an': [5], 'emerging': [6], 'class': [7], 'of': [8, 43, 61, 72, 82, 144, 168, 179, 197, 206, 220, 223, 230, 238, 247, 262, 277, 279, 288], 'therapeutics': [9], 'with': [10, 123], 'potential': [11, 114], 'as': [12, 25, 41, 100, 118, 253, 265], 'anticancer': [13, 26, 125, 195], 'drugs.': [14], 'The': [15, 59], 'rationale': [16], 'for': [17, 141, 165, 235, 268], 'developing': [18], 'HDAC': [19, 44, 62, 87, 110, 131, 181, 199, 207, 210, 224, 248, 263, 280], '(and': [21], 'other': [22, 124], 'chromatin-modifying': [23], 'agents)': [24], 'therapies': [27, 267], 'arose': [28], 'from': [29, 137], 'the': [30, 113, 138, 142, 166, 177, 193, 221, 236, 244, 260, 273, 284], 'understanding': [31, 219], 'that': [32, 78, 133, 250], 'in': [33, 80, 94, 97, 107, 121, 291], 'addition': [34], 'to': [35, 56, 115, 242, 294], 'genetic': [36], 'mutations,': [37], 'epigenetic': [38], 'changes': [39], 'such': [40, 99], 'dysregulation': [42], 'enzymes': [45, 208], 'can': [46], 'alter': [47], 'phenotype': [48], 'and': [49, 54, 66, 75, 85, 96, 105, 153, 185, 209, 228, 275, 286], 'gene': [50], 'expression,': [51], 'disturb': [52], 'homeostasis,': [53], 'contribute': [55], 'neoplastic': [57], 'growth.': [58], 'family': [60], 'is': [64], 'large': [65], 'diverse.': [67], 'It': [68], 'includes': [69], 'a': [70], 'range': [71], 'naturally': [73], 'occurring': [74], 'synthetic': [76], 'compounds': [77, 290], 'differ': [79], 'terms': [81], 'structure,': [83], 'function,': [84], 'specificity.': [86], 'have': [89, 112, 134], 'multiple': [90], 'cell': [91, 103], 'type-specific': [92], 'effects': [93, 178, 196, 222], 'vitro': [95], 'vivo,': [98], 'growth': [101], 'arrest,': [102], 'differentiation,': [104], 'apoptosis': [106], 'malignant': [108], 'cells.': [109], 'be': [116, 233], 'used': [117], 'monotherapies': [119], 'or': [120], 'combination': [122], 'therapies.': [126], 'Currently,': [127], 'there': [128], 'two': [130], 'received': [135], 'approval': [136, 164], 'US': [139], 'FDA': [140, 163], 'treatment': [143, 167], 'cutaneous': [145], 'T-cell': [146, 170], 'lymphoma:': [147], 'vorinostat': [148], '(suberoylanilide': [149], 'hydroxamic': [150], 'acid,': [151], 'Zolinza)': [152], 'depsipeptide': [154, 159], '(romidepsin,': [155], 'Istodax).': [156], 'More': [157], 'recently,': [158], 'has': [160], 'also': [161], 'gained': [162], 'peripheral': [169], 'lymphoma.': [171], 'Many': [172], 'more': [173], 'clinical': [174, 292], 'trials': [175], 'assessing': [176], 'various': [180], 'on': [183], 'hematological': [184], 'solid': [186], 'malignancies': [187], 'currently': [189], 'being': [190], 'conducted.': [191], 'Despite': [192], 'proven': [194], 'particular': [198], 'against': [201], 'certain': [202], 'cancers,': [203], 'many': [204], 'aspects': [205], 'still': [213], 'not': [214], 'fully': [215], 'understood.': [216], 'Increasing': [217], 'our': [218], 'inhibitors,': [225], 'their': [226], 'targets': [227], 'mechanisms': [229, 276], 'action': [231, 278], 'will': [232, 258], 'critical': [234], 'advancement': [237], 'these': [239, 289], 'drugs,': [240], 'especially': [241], 'facilitate': [243], 'rational': [245], 'design': [246], 'effective': [252], 'antineoplastic': [254], 'agents.': [255], 'This': [256], 'review': [257], 'discuss': [259], 'use': [261], 'multitargeted': [266], 'malignancy.': [269], 'Further,': [270], 'we': [271], 'outline': [272], 'pharmacology': [274], 'while': [282], 'discussing': [283], 'safety': [285], 'efficacy': [287], 'studies': [293], 'date.': [295]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083124842', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 29}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 30}, {'year': 2016, 'cited_by_count': 32}, {'year': 2015, 'cited_by_count': 34}, {'year': 2014, 'cited_by_count': 36}, {'year': 2013, 'cited_by_count': 15}], 'updated_date': '2025-01-08T01:20:27.973677', 'created_date': '2016-06-24'}