Publication Information

{'id': 'https://openalex.org/W2083033452', 'doi': 'https://doi.org/10.1097/wnf.0b013e3180645cb0', 'title': 'Effects of Nebicapone on Levodopa Pharmacokinetics, Catechol-O-methyltransferase Activity, and Motor Fluctuations in Patients with Parkinson Disease', 'display_name': 'Effects of Nebicapone on Levodopa Pharmacokinetics, Catechol-O-methyltransferase Activity, and Motor Fluctuations in Patients with Parkinson Disease', 'publication_year': 2008, 'publication_date': '2008-01-01', 'ids': {'openalex': 'https://openalex.org/W2083033452', 'doi': 'https://doi.org/10.1097/wnf.0b013e3180645cb0', 'mag': '2083033452', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18303486'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/wnf.0b013e3180645cb0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3349026', 'display_name': 'Clinical Neuropharmacology', 'issn_l': '0362-5664', 'issn': ['0362-5664', '1537-162X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015724259', 'display_name': 'Joaquim J. Ferreira', 'orcid': 'https://orcid.org/0000-0003-3950-5113'}, 'institutions': [{'id': 'https://openalex.org/I4210146488', 'display_name': 'Institute of Molecular Medicine', 'ror': 'https://ror.org/04eb14s37', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210146488']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Joaquim J. Ferreira', 'raw_affiliation_strings': ['Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon'], 'affiliations': [{'raw_affiliation_string': 'Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon', 'institution_ids': ['https://openalex.org/I4210146488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023609484', 'display_name': 'Luís Almeida', 'orcid': 'https://orcid.org/0000-0002-4861-8649'}, 'institutions': [{'id': 'https://openalex.org/I108511484', 'display_name': 'Bial (Portugal)', 'ror': 'https://ror.org/02htdjb57', 'country_code': 'PT', 'type': 'company', 'lineage': ['https://openalex.org/I108511484']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Luis Almeida', 'raw_affiliation_strings': ['Department of Research and Development, BIAL (Portela & Ca SA), S Mamede do Coronado'], 'affiliations': [{'raw_affiliation_string': 'Department of Research and Development, BIAL (Portela & Ca SA), S Mamede do Coronado', 'institution_ids': ['https://openalex.org/I108511484']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083504892', 'display_name': 'Luı́s Cunha', 'orcid': 'https://orcid.org/0000-0002-0828-3485'}, 'institutions': [{'id': 'https://openalex.org/I2802025818', 'display_name': 'Hospitais da Universidade de Coimbra', 'ror': 'https://ror.org/04032fz76', 'country_code': 'PT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802025818']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Luis Cunha', 'raw_affiliation_strings': ['Department of Neurology, Hospitais da Universidade de Coimbra, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Hospitais da Universidade de Coimbra, Portugal', 'institution_ids': ['https://openalex.org/I2802025818']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003904928', 'display_name': 'Marina Ticmeanu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153981', 'display_name': 'Spitalul Clinic Colentina', 'ror': 'https://ror.org/04fkbqt11', 'country_code': 'RO', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153981']}], 'countries': ['RO'], 'is_corresponding': False, 'raw_author_name': 'Marina Ticmeanu', 'raw_affiliation_strings': ['Department of Neurology, Spitalul Clinic Colentina, Bucharest, Romania'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Spitalul Clinic Colentina, Bucharest, Romania', 'institution_ids': ['https://openalex.org/I4210153981']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069027652', 'display_name': 'Mário Miguel Rosa', 'orcid': 'https://orcid.org/0000-0003-3158-2106'}, 'institutions': [{'id': 'https://openalex.org/I4210146488', 'display_name': 'Institute of Molecular Medicine', 'ror': 'https://ror.org/04eb14s37', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210146488']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Mário M. Rosa', 'raw_affiliation_strings': ['Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon'], 'affiliations': [{'raw_affiliation_string': 'Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon', 'institution_ids': ['https://openalex.org/I4210146488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049145557', 'display_name': 'Cristina Januário', 'orcid': 'https://orcid.org/0000-0001-5402-3978'}, 'institutions': [{'id': 'https://openalex.org/I2802025818', 'display_name': 'Hospitais da Universidade de Coimbra', 'ror': 'https://ror.org/04032fz76', 'country_code': 'PT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802025818']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Cristina Januário', 'raw_affiliation_strings': ['Department of Neurology, Hospitais da Universidade de Coimbra, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Hospitais da Universidade de Coimbra, Portugal', 'institution_ids': ['https://openalex.org/I2802025818']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032304846', 'display_name': 'Cristina-Elena Mitu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153981', 'display_name': 'Spitalul Clinic Colentina', 'ror': 'https://ror.org/04fkbqt11', 'country_code': 'RO', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153981']}], 'countries': ['RO'], 'is_corresponding': False, 'raw_author_name': 'Cristina-Elena Mitu', 'raw_affiliation_strings': ['Department of Neurology, Spitalul Clinic Colentina, Bucharest, Romania'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Spitalul Clinic Colentina, Bucharest, Romania', 'institution_ids': ['https://openalex.org/I4210153981']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035961119', 'display_name': 'Miguel Coelho', 'orcid': 'https://orcid.org/0000-0002-4008-8110'}, 'institutions': [{'id': 'https://openalex.org/I4210146488', 'display_name': 'Institute of Molecular Medicine', 'ror': 'https://ror.org/04eb14s37', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210146488']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Miguel Coelho', 'raw_affiliation_strings': ['Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon'], 'affiliations': [{'raw_affiliation_string': 'Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon', 'institution_ids': ['https://openalex.org/I4210146488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050316684', 'display_name': 'Leonor Correia Guedes', 'orcid': 'https://orcid.org/0000-0002-8422-0494'}, 'institutions': [{'id': 'https://openalex.org/I4210146488', 'display_name': 'Institute of Molecular Medicine', 'ror': 'https://ror.org/04eb14s37', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210146488']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Leonor Correia-Guedes', 'raw_affiliation_strings': ['Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon'], 'affiliations': [{'raw_affiliation_string': 'Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon', 'institution_ids': ['https://openalex.org/I4210146488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011954447', 'display_name': 'Ana Morgadinho', 'orcid': 'https://orcid.org/0000-0001-6841-251X'}, 'institutions': [{'id': 'https://openalex.org/I2802025818', 'display_name': 'Hospitais da Universidade de Coimbra', 'ror': 'https://ror.org/04032fz76', 'country_code': 'PT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802025818']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Ana Morgadinho', 'raw_affiliation_strings': ['Department of Neurology, Hospitais da Universidade de Coimbra, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Hospitais da Universidade de Coimbra, Portugal', 'institution_ids': ['https://openalex.org/I2802025818']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007617140', 'display_name': 'Teresa Nunes', 'orcid': 'https://orcid.org/0000-0002-7206-3065'}, 'institutions': [{'id': 'https://openalex.org/I108511484', 'display_name': 'Bial (Portugal)', 'ror': 'https://ror.org/02htdjb57', 'country_code': 'PT', 'type': 'company', 'lineage': ['https://openalex.org/I108511484']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Teresa Nunes', 'raw_affiliation_strings': ['Department of Research and Development, BIAL (Portela & Ca SA), S Mamede do Coronado'], 'affiliations': [{'raw_affiliation_string': 'Department of Research and Development, BIAL (Portela & Ca SA), S Mamede do Coronado', 'institution_ids': ['https://openalex.org/I108511484']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090795661', 'display_name': 'Lyndon Wright', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I108511484', 'display_name': 'Bial (Portugal)', 'ror': 'https://ror.org/02htdjb57', 'country_code': 'PT', 'type': 'company', 'lineage': ['https://openalex.org/I108511484']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Lyndon C. Wright', 'raw_affiliation_strings': ['Department of Research and Development, BIAL (Portela & Ca SA), S Mamede do Coronado'], 'affiliations': [{'raw_affiliation_string': 'Department of Research and Development, BIAL (Portela & Ca SA), S Mamede do Coronado', 'institution_ids': ['https://openalex.org/I108511484']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005703800', 'display_name': 'Amílcar Falcão', 'orcid': 'https://orcid.org/0000-0002-3854-6549'}, 'institutions': [], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Amílcar Falcão', 'raw_affiliation_strings': ['4Health Ltd, Cantanhede, Portugal.'], 'affiliations': [{'raw_affiliation_string': '4Health Ltd, Cantanhede, Portugal.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003014019', 'display_name': 'Cristina Sampaio', 'orcid': 'https://orcid.org/0000-0002-7052-9079'}, 'institutions': [{'id': 'https://openalex.org/I4210146488', 'display_name': 'Institute of Molecular Medicine', 'ror': 'https://ror.org/04eb14s37', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210146488']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Cristina Sampaio', 'raw_affiliation_strings': ['Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon'], 'affiliations': [{'raw_affiliation_string': 'Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon', 'institution_ids': ['https://openalex.org/I4210146488']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078712323', 'display_name': 'Patrı́cio Soares-da-Silva', 'orcid': 'https://orcid.org/0000-0002-2446-5078'}, 'institutions': [{'id': 'https://openalex.org/I108511484', 'display_name': 'Bial (Portugal)', 'ror': 'https://ror.org/02htdjb57', 'country_code': 'PT', 'type': 'company', 'lineage': ['https://openalex.org/I108511484']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Patrício Soares-da-Silva', 'raw_affiliation_strings': ['Department of Research and Development, BIAL (Portela & Ca SA), S Mamede do Coronado'], 'affiliations': [{'raw_affiliation_string': 'Department of Research and Development, BIAL (Portela & Ca SA), S Mamede do Coronado', 'institution_ids': ['https://openalex.org/I108511484']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5015724259', 'https://openalex.org/A5069027652', 'https://openalex.org/A5035961119', 'https://openalex.org/A5050316684', 'https://openalex.org/A5003014019'], 'corresponding_institution_ids': ['https://openalex.org/I4210146488', 'https://openalex.org/I4210146488', 'https://openalex.org/I4210146488', 'https://openalex.org/I4210146488', 'https://openalex.org/I4210146488'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.292, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 31, 'citation_normalized_percentile': {'value': 0.809695, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '31', 'issue': '1', 'first_page': '2', 'last_page': '18'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10919', 'display_name': 'Neurological disorders and treatments', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorder Research', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/entacapone', 'display_name': 'Entacapone', 'score': 0.45088398}, {'id': 'https://openalex.org/keywords/catechol', 'display_name': 'Catechol', 'score': 0.43171754}], 'concepts': [{'id': 'https://openalex.org/C185361966', 'wikidata': 'https://www.wikidata.org/wiki/Q94291140', 'display_name': 'Catechol-O-methyl transferase', 'level': 4, 'score': 0.87515724}, {'id': 'https://openalex.org/C2780304432', 'wikidata': 'https://www.wikidata.org/wiki/Q300989', 'display_name': 'Levodopa', 'level': 4, 'score': 0.84496367}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.68578386}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.6768573}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4940832}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45337623}, {'id': 'https://openalex.org/C2776976799', 'wikidata': 'https://www.wikidata.org/wiki/Q416444', 'display_name': 'Entacapone', 'level': 5, 'score': 0.45088398}, {'id': 'https://openalex.org/C2777713698', 'wikidata': 'https://www.wikidata.org/wiki/Q282440', 'display_name': 'Catechol', 'level': 2, 'score': 0.43171754}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.37839204}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.34397995}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.29503134}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18690154}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000098', 'descriptor_name': 'Acetophenones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000978', 'descriptor_name': 'Antiparkinson Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D065098', 'descriptor_name': 'Catechol O-Methyltransferase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007980', 'descriptor_name': 'Levodopa', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000098', 'descriptor_name': 'Acetophenones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000978', 'descriptor_name': 'Antiparkinson Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000978', 'descriptor_name': 'Antiparkinson Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002230', 'descriptor_name': 'Carbidopa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002230', 'descriptor_name': 'Carbidopa', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002396', 'descriptor_name': 'Catechols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002396', 'descriptor_name': 'Catechols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018592', 'descriptor_name': 'Cross-Over Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007980', 'descriptor_name': 'Levodopa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007980', 'descriptor_name': 'Levodopa', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009043', 'descriptor_name': 'Motor Activity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009043', 'descriptor_name': 'Motor Activity', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D010919', 'descriptor_name': 'Placebos', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/wnf.0b013e3180645cb0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3349026', 'display_name': 'Clinical Neuropharmacology', 'issn_l': '0362-5664', 'issn': ['0362-5664', '1537-162X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18303486', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.8}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1732912328', 'https://openalex.org/W1965128384', 'https://openalex.org/W1977040566', 'https://openalex.org/W1982426372', 'https://openalex.org/W1992942062', 'https://openalex.org/W2016013480', 'https://openalex.org/W2018371145', 'https://openalex.org/W2019021573', 'https://openalex.org/W2020613687', 'https://openalex.org/W2023765475', 'https://openalex.org/W2030556805', 'https://openalex.org/W2035942308', 'https://openalex.org/W2049993495', 'https://openalex.org/W2051557976', 'https://openalex.org/W2051723119', 'https://openalex.org/W2059952048', 'https://openalex.org/W2062697517', 'https://openalex.org/W2066643651', 'https://openalex.org/W2066821514', 'https://openalex.org/W2071651331', 'https://openalex.org/W2076976831', 'https://openalex.org/W2086701255', 'https://openalex.org/W2093331618', 'https://openalex.org/W2107019855', 'https://openalex.org/W2111505835', 'https://openalex.org/W2128573832', 'https://openalex.org/W2129577292', 'https://openalex.org/W2131639227', 'https://openalex.org/W2132881915', 'https://openalex.org/W2134178274', 'https://openalex.org/W2149711671', 'https://openalex.org/W3022890122', 'https://openalex.org/W3090293687', 'https://openalex.org/W4285719527', 'https://openalex.org/W93112319'], 'related_works': ['https://openalex.org/W9620540', 'https://openalex.org/W4307658853', 'https://openalex.org/W2409123857', 'https://openalex.org/W2133840774', 'https://openalex.org/W2115601613', 'https://openalex.org/W2095754699', 'https://openalex.org/W2083033452', 'https://openalex.org/W2051049259', 'https://openalex.org/W2017055459', 'https://openalex.org/W1984702297'], 'abstract_inverted_index': {'To': [0], 'investigate': [1], 'the': [2, 66, 99, 114, 154], 'effects': [3], 'of': [4, 34, 68, 136, 190, 217, 264], 'nebicapone,': [5, 88, 91, 167, 173, 196, 202], 'a': [6, 71, 184, 240], 'new': [7, 241], 'catechol-O-methyltransferase': [8], '(COMT)': [9], 'inhibitor,': [10, 243], 'on': [11], 'levodopa': [12, 72, 77, 96, 155], 'pharmacokinetics,': [13], 'COMT': [14, 82, 127, 137, 242, 246], 'activity,': [15, 247], 'and': [16, 26, 59, 76, 78, 81, 92, 108, 110, 123, 144, 174, 203, 210, 220, 229, 253], 'motor': [17, 255], 'fluctuations': [18], 'in': [19, 22, 42, 186, 213, 234, 261], 'Parkinson': [20], 'disease': [21], 'comparison': [23], 'to': [24, 53, 251], 'placebo': [25], 'entacapone.Randomized,': [27], 'double-blind,': [28], 'placebo-controlled,': [29], '4-way': [30], 'crossover': [31], 'study': [32], 'consisting': [33], '4': [35], 'treatment': [36], 'periods': [37], '(6-9': [38], 'days': [39], 'duration': [40], 'each)': [41], '19': [43], 'patients': [44], '(65.3': [45], '+/-': [46], '8.5': [47], 'years)': [48], 'treated': [49], 'with': [50, 142, 149, 164, 170, 177, 193, 199, 206], 'carbidopa/levodopa': [51, 60], '3': [52], '7': [54], 'times': [55], 'per': [56], 'day.': [57], 'Nebicapone/entacapone/placebo': [58], 'doses': [61], 'were': [62, 84, 225, 238], 'administered': [63], 'concomitantly.': [64], 'At': [65], 'end': [67], 'each': [69], 'period,': [70], 'test': [73, 156], 'was': [74, 129, 139], 'performed,': [75], '3-O-methyldopa': [79, 111], 'levels': [80], 'activity': [83], 'assayed.After': [85], '75': [86, 143, 165, 194], 'mg': [87, 90, 94, 146, 151, 166, 172, 179, 195, 201, 208], '150': [89, 145, 171, 200], '200': [93, 150, 178, 207], 'entacapone,': [95, 209], 'area': [97, 112], 'under': [98, 113], 'plasma': [100, 115], 'concentration': [101, 116], 'time': [102, 117, 159, 189, 216], 'curve': [103, 118], 'significantly': [104, 119, 160, 244], 'increased': [105, 161, 248], '28.1,': [106], '48.4,': [107], '33.3%,': [109], 'decreased': [120, 245], '59.2,': [121], '70.8,': [122], '59.1%,': [124], 'respectively.': [125, 223], 'Peak': [126], 'inhibition': [128, 138], 'similar': [130], 'between': [131], 'active': [132], 'treatments,': [133], 'but': [134], 'extent': [135], 'more': [140], 'sustained': [141], 'nebicapone': [147], 'than': [148], 'entacapone.': [152, 180], 'After': [153], 'doses,': [157], 'ON': [158, 215], '29': [162], 'minutes': [163, 169, 176, 192, 198, 205], '45': [168], '16': [175], "Patients'": [181], 'diaries': [182], 'showed': [183], 'decrease': [185], 'daily': [187, 214], 'OFF': [188], '109': [191], '103': [197], '71': [204], 'an': [211], 'increase': [212], '74,': [218], '101,': [219], '74': [221], 'minutes,': [222], 'Treatments': [224], 'generally': [226], 'well': [227], 'tolerated': [228], 'safe;': [230], 'no': [231], 'relevant': [232], 'changes': [233], 'liver': [235], 'function': [236], 'tests': [237], 'reported.Nebicapone,': [239], 'systemic': [249], 'exposure': [250], 'levodopa,': [252], 'improved': [254], 'response.': [256], 'Nebicapone': [257], 'deserves': [258], 'further': [259], 'evaluation': [260], 'larger': [262], 'samples': [263], 'patients.': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083033452', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-14T10:43:45.692763', 'created_date': '2016-06-24'}