Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2082994012', 'doi': 'https://doi.org/10.1073/pnas.90.12.5677', 'title': 'A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.', 'display_name': 'A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.', 'publication_year': 1993, 'publication_date': '1993-06-15', 'ids': {'openalex': 'https://openalex.org/W2082994012', 'doi': 'https://doi.org/10.1073/pnas.90.12.5677', 'mag': '2082994012', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8390675', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/47884'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.90.12.5677', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.90.12.5677', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011864132', 'display_name': 'J D Johnson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J D Johnson', 'raw_affiliation_strings': ['Hormone Research Institute, University of California, San Francisco 94143-0534.'], 'affiliations': [{'raw_affiliation_string': 'Hormone Research Institute, University of California, San Francisco 94143-0534.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074332765', 'display_name': 'J C Edman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J C Edman', 'raw_affiliation_strings': ['Hormone Research Institute, University of California, San Francisco 94143-0534.'], 'affiliations': [{'raw_affiliation_string': 'Hormone Research Institute, University of California, San Francisco 94143-0534.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036382303', 'display_name': 'William J. Rutter', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W J Rutter', 'raw_affiliation_strings': ['Hormone Research Institute, University of California, San Francisco 94143-0534.'], 'affiliations': [{'raw_affiliation_string': 'Hormone Research Institute, University of California, San Francisco 94143-0534.', 'institution_ids': ['https://openalex.org/I180670191']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 176, 'citation_normalized_percentile': {'value': 0.714286, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '90', 'issue': '12', 'first_page': '5677', 'last_page': '5681'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12387', 'display_name': 'Role of Galectins in Immunity and Disease', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/discoidin-domain', 'display_name': 'Discoidin domain', 'score': 0.8469617}, {'id': 'https://openalex.org/keywords/ddr1', 'display_name': 'DDR1', 'score': 0.6657126}, {'id': 'https://openalex.org/keywords/protein-kinase-domain', 'display_name': 'Protein kinase domain', 'score': 0.4531314}, {'id': 'https://openalex.org/keywords/focal-adhesion-kinase', 'display_name': 'Focal Adhesion Kinase', 'score': 0.43623}, {'id': 'https://openalex.org/keywords/ror1', 'display_name': 'ROR1', 'score': 0.43609923}, {'id': 'https://openalex.org/keywords/receptor-protein-tyrosine-kinases', 'display_name': 'Receptor Protein-Tyrosine Kinases', 'score': 0.42166114}], 'concepts': [{'id': 'https://openalex.org/C2776305115', 'wikidata': 'https://www.wikidata.org/wiki/Q24727589', 'display_name': 'Discoidin domain', 'level': 4, 'score': 0.8469617}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.75920796}, {'id': 'https://openalex.org/C152681006', 'wikidata': 'https://www.wikidata.org/wiki/Q17854856', 'display_name': 'DDR1', 'level': 4, 'score': 0.6657126}, {'id': 'https://openalex.org/C2775969001', 'wikidata': 'https://www.wikidata.org/wiki/Q134351', 'display_name': 'Dictyostelium discoideum', 'level': 3, 'score': 0.63156945}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5306788}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.5233195}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.50732344}, {'id': 'https://openalex.org/C2776165026', 'wikidata': 'https://www.wikidata.org/wiki/Q188017', 'display_name': 'Tyrosine', 'level': 2, 'score': 0.5071957}, {'id': 'https://openalex.org/C32619005', 'wikidata': 'https://www.wikidata.org/wiki/Q24768234', 'display_name': 'Protein kinase domain', 'level': 4, 'score': 0.4531314}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43679494}, {'id': 'https://openalex.org/C23440912', 'wikidata': 'https://www.wikidata.org/wiki/Q18030230', 'display_name': 'ROR1', 'level': 5, 'score': 0.43609923}, {'id': 'https://openalex.org/C118892022', 'wikidata': 'https://www.wikidata.org/wiki/Q7834587', 'display_name': 'Transmembrane domain', 'level': 3, 'score': 0.42366016}, {'id': 'https://openalex.org/C2911166042', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor Protein-Tyrosine Kinases', 'level': 4, 'score': 0.42166114}, {'id': 'https://openalex.org/C180361614', 'wikidata': 'https://www.wikidata.org/wiki/Q7202242', 'display_name': 'Platelet-derived growth factor receptor', 'level': 4, 'score': 0.36493933}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.3566429}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.34843725}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.33339852}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32642472}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.25616652}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.05832374}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.90.12.5677', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc47884', 'pdf_url': 'https://europepmc.org/articles/pmc47884?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc46784', 'pdf_url': 'https://europepmc.org/articles/pmc46784?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46784', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8248187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.90.12.5677', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1014698510', 'https://openalex.org/W1164935966', 'https://openalex.org/W1513997167', 'https://openalex.org/W1516117732', 'https://openalex.org/W1594700207', 'https://openalex.org/W1607784649', 'https://openalex.org/W1611126668', 'https://openalex.org/W1654852813', 'https://openalex.org/W1863695472', 'https://openalex.org/W1967104104', 'https://openalex.org/W2004404376', 'https://openalex.org/W2008511010', 'https://openalex.org/W2009928329', 'https://openalex.org/W2021283345', 'https://openalex.org/W2026790970', 'https://openalex.org/W2030156849', 'https://openalex.org/W2045348184', 'https://openalex.org/W2056483677', 'https://openalex.org/W2069472625', 'https://openalex.org/W2083974381', 'https://openalex.org/W2087799413', 'https://openalex.org/W2091239909', 'https://openalex.org/W2095103087', 'https://openalex.org/W2095526534', 'https://openalex.org/W2095606352', 'https://openalex.org/W2120140317', 'https://openalex.org/W2139397808', 'https://openalex.org/W2152678670', 'https://openalex.org/W2199020419', 'https://openalex.org/W38611617', 'https://openalex.org/W4238362700'], 'related_works': ['https://openalex.org/W3130067263', 'https://openalex.org/W3030491230', 'https://openalex.org/W2889771740', 'https://openalex.org/W2516097337', 'https://openalex.org/W2187245249', 'https://openalex.org/W2184894459', 'https://openalex.org/W2156008954', 'https://openalex.org/W2093784914', 'https://openalex.org/W1970149293', 'https://openalex.org/W1928836998'], 'abstract_inverted_index': {'We': [0], 'have': [1], 'identified': [2], 'a': [3, 25, 56, 95], 'breast': [4], 'carcinoma': [5], 'tyrosine': [6, 19, 27], 'phosphoprotein,': [7], 'discoidin': [8, 40], 'domain': [9, 29, 33], 'receptor': [10, 18], '(DDR),': [11], 'that': [12, 99], 'defines': [13], 'an': [14, 31, 47, 68], 'unusual': [15, 69], 'class': [16, 96], 'of': [17, 71, 97], 'kinases.': [20], 'The': [21], 'DDR': [22], 'cDNA': [23], 'predicts': [24], 'C-terminal': [26], 'kinase': [28], 'and': [30, 90, 92], 'N-terminal': [32], 'similar': [34], 'to': [35], 'the': [36], 'Dictyostelium': [37], 'discoideum': [38], 'lectin': [39], 'I.': [41], 'These': [42], 'domains': [43, 79, 98], 'are': [44, 80], 'connected': [45], 'by': [46, 55], 'extraordinary': [48], 'hydrophilic': [49], 'proline/glycine-rich': [50, 62], 'domain,': [51], 'which': [52], 'is': [53], 'interrupted': [54], 'predicted': [57], 'transmembrane': [58], 'sequence.': [59], 'This': [60], 'extended': [61], 'region': [63], 'may': [64, 93], 'be': [65], 'required': [66], 'for': [67], 'geometry': [70], 'interaction': [72], 'with': [73, 101], 'ligand': [74], 'or': [75], 'substrates.': [76], 'Discoidin': [77], 'I': [78], 'also': [81], 'found': [82], 'in': [83], 'other': [84], 'proteins,': [85], 'including': [86], 'coagulation': [87], 'factors': [88], 'V': [89], 'VIII,': [91], 'represent': [94], 'interact': [100], 'specific': [102], 'cell': [103], 'surface': [104], 'molecules.': [105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082994012', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-09T19:59:02.964652', 'created_date': '2016-06-24'}