Publication Information

{'id': 'https://openalex.org/W2082981840', 'doi': 'https://doi.org/10.1002/tcm.1770070106', 'title': 'Evaluation of 60 chemicals in a preliminary developmental toxicity test', 'display_name': 'Evaluation of 60 chemicals in a preliminary developmental toxicity test', 'publication_year': 1987, 'publication_date': '1987-01-01', 'ids': {'openalex': 'https://openalex.org/W2082981840', 'doi': 'https://doi.org/10.1002/tcm.1770070106', 'mag': '2082981840', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2884741'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/tcm.1770070106', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S23975315', 'display_name': 'Birth Defects Research', 'issn_l': '2472-1727', 'issn': ['2472-1727'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110355081', 'display_name': 'Bryan D. Hardin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I198423848', 'display_name': 'National Institute for Occupational Safety and Health', 'ror': 'https://ror.org/0502a2655', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289490764', 'https://openalex.org/I1299022934', 'https://openalex.org/I198423848']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bryan D. Hardin', 'raw_affiliation_strings': ['National Institute for Occupational Safety and Health; Cincinnati Ohio'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Occupational Safety and Health; Cincinnati Ohio', 'institution_ids': ['https://openalex.org/I198423848']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029568176', 'display_name': 'Ronald L. Schuler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I198423848', 'display_name': 'National Institute for Occupational Safety and Health', 'ror': 'https://ror.org/0502a2655', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289490764', 'https://openalex.org/I1299022934', 'https://openalex.org/I198423848']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ronald L. Schuler', 'raw_affiliation_strings': ['National Institute for Occupational Safety and Health; Cincinnati Ohio'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Occupational Safety and Health; Cincinnati Ohio', 'institution_ids': ['https://openalex.org/I198423848']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111583494', 'display_name': 'Jeanne R. Burg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I198423848', 'display_name': 'National Institute for Occupational Safety and Health', 'ror': 'https://ror.org/0502a2655', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289490764', 'https://openalex.org/I1299022934', 'https://openalex.org/I198423848']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'JeAnne R. Burg', 'raw_affiliation_strings': ['National Institute for Occupational Safety and Health; Cincinnati Ohio'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Occupational Safety and Health; Cincinnati Ohio', 'institution_ids': ['https://openalex.org/I198423848']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113839752', 'display_name': 'Gary M. Booth', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gary M. Booth', 'raw_affiliation_strings': ['Minority Enterprise Service Associates, Orem, Utah'], 'affiliations': [{'raw_affiliation_string': 'Minority Enterprise Service Associates, Orem, Utah', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053400784', 'display_name': 'Keith P. Hazelden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210109752', 'display_name': 'Research International (United States)', 'ror': 'https://ror.org/01ev6a639', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210109752']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Keith P. Hazelden', 'raw_affiliation_strings': ['Inveresk Research International, Ltd., Edinburgh, Scotland'], 'affiliations': [{'raw_affiliation_string': 'Inveresk Research International, Ltd., Edinburgh, Scotland', 'institution_ids': ['https://openalex.org/I4210109752']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069788875', 'display_name': 'Karen Mackenzie', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Karen M. MacKenzie', 'raw_affiliation_strings': ['Hazleton Laboratories America, Madison, Wisconsin'], 'affiliations': [{'raw_affiliation_string': 'Hazleton Laboratories America, Madison, Wisconsin', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052704608', 'display_name': 'Vincent J. Piccirillo', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vincent J. Piccirillo', 'raw_affiliation_strings': ['Borriston Laboratories, Inc., Temple Hills, Maryland'], 'affiliations': [{'raw_affiliation_string': 'Borriston Laboratories, Inc., Temple Hills, Maryland', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001185780', 'display_name': 'Kirby N. Smith', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121470', 'display_name': 'BioAssay Systems (United States)', 'ror': 'https://ror.org/02szfyr26', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kirby N. Smith', 'raw_affiliation_strings': ['Bioassay Systems Corporation, Woburn, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Bioassay Systems Corporation, Woburn, Massachusetts', 'institution_ids': ['https://openalex.org/I4210121470']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3350, 'currency': 'USD', 'value_usd': 3350, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.683, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 201, 'citation_normalized_percentile': {'value': 0.973311, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '7', 'issue': '1', 'first_page': '29', 'last_page': '48'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10686', 'display_name': 'Effects and risks of endocrine disrupting chemicals', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10686', 'display_name': 'Effects and risks of endocrine disrupting chemicals', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10433', 'display_name': 'Carcinogens and Genotoxicity Assessment', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12281', 'display_name': 'Animal testing and alternatives', 'score': 0.9824, 'subfield': {'id': 'https://openalex.org/subfields/3404', 'display_name': 'Small Animals'}, 'field': {'id': 'https://openalex.org/fields/34', 'display_name': 'Veterinary'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/developmental-toxicity', 'display_name': 'Developmental toxicity', 'score': 0.8357271}, {'id': 'https://openalex.org/keywords/triethylene-glycol', 'display_name': 'Triethylene glycol', 'score': 0.76957595}, {'id': 'https://openalex.org/keywords/diethylene-glycol', 'display_name': 'Diethylene glycol', 'score': 0.75318456}, {'id': 'https://openalex.org/keywords/litter', 'display_name': 'Litter', 'score': 0.56463635}], 'concepts': [{'id': 'https://openalex.org/C65290608', 'wikidata': 'https://www.wikidata.org/wiki/Q631521', 'display_name': 'Teratology', 'level': 4, 'score': 0.8986473}, {'id': 'https://openalex.org/C179335377', 'wikidata': 'https://www.wikidata.org/wiki/Q5266825', 'display_name': 'Developmental toxicity', 'level': 4, 'score': 0.8357271}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.8033831}, {'id': 'https://openalex.org/C2777516009', 'wikidata': 'https://www.wikidata.org/wiki/Q194207', 'display_name': 'Ethylene glycol', 'level': 2, 'score': 0.79471374}, {'id': 'https://openalex.org/C2775934670', 'wikidata': 'https://www.wikidata.org/wiki/Q420630', 'display_name': 'Triethylene glycol', 'level': 2, 'score': 0.76957595}, {'id': 'https://openalex.org/C2779136216', 'wikidata': 'https://www.wikidata.org/wiki/Q421902', 'display_name': 'Diethylene glycol', 'level': 3, 'score': 0.75318456}, {'id': 'https://openalex.org/C33070731', 'wikidata': 'https://www.wikidata.org/wiki/Q7218', 'display_name': 'Toxicology', 'level': 1, 'score': 0.68275535}, {'id': 'https://openalex.org/C2779429622', 'wikidata': 'https://www.wikidata.org/wiki/Q1780867', 'display_name': 'Litter', 'level': 2, 'score': 0.56463635}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.54201233}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38042757}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.366811}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.351847}, {'id': 'https://openalex.org/C2779234561', 'wikidata': 'https://www.wikidata.org/wiki/Q11995', 'display_name': 'Pregnancy', 'level': 2, 'score': 0.23573682}, {'id': 'https://openalex.org/C172680121', 'wikidata': 'https://www.wikidata.org/wiki/Q26513', 'display_name': 'Fetus', 'level': 3, 'score': 0.19618866}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.15340099}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.14075589}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C6557445', 'wikidata': 'https://www.wikidata.org/wiki/Q173113', 'display_name': 'Agronomy', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D013723', 'descriptor_name': 'Teratogens', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001835', 'descriptor_name': 'Body Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001835', 'descriptor_name': 'Body Weight', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005865', 'descriptor_name': 'Gestational Age', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012098', 'descriptor_name': 'Reproduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012098', 'descriptor_name': 'Reproduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013723', 'descriptor_name': 'Teratogens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/tcm.1770070106', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S23975315', 'display_name': 'Birth Defects Research', 'issn_l': '2472-1727', 'issn': ['2472-1727'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2884741', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W131883444', 'https://openalex.org/W132041327', 'https://openalex.org/W1542115623', 'https://openalex.org/W1972044418', 'https://openalex.org/W1975890447', 'https://openalex.org/W1985692939', 'https://openalex.org/W1988203224', 'https://openalex.org/W1989474424', 'https://openalex.org/W1998897262', 'https://openalex.org/W2001441698', 'https://openalex.org/W2007916806', 'https://openalex.org/W2011377185', 'https://openalex.org/W2023586439', 'https://openalex.org/W2025852990', 'https://openalex.org/W2034409026', 'https://openalex.org/W2035994145', 'https://openalex.org/W2039196506', 'https://openalex.org/W2055814683', 'https://openalex.org/W2090574584', 'https://openalex.org/W2137899112', 'https://openalex.org/W2146778637', 'https://openalex.org/W2155615078', 'https://openalex.org/W2401078901', 'https://openalex.org/W2439323312', 'https://openalex.org/W4300450725'], 'related_works': ['https://openalex.org/W4248707322', 'https://openalex.org/W4233773758', 'https://openalex.org/W3033353968', 'https://openalex.org/W2605821943', 'https://openalex.org/W2554473373', 'https://openalex.org/W2354731326', 'https://openalex.org/W2088013438', 'https://openalex.org/W2087173778', 'https://openalex.org/W2061537172', 'https://openalex.org/W2054362354'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'number': [2], 'of': [3, 19, 61, 67, 115, 144, 155, 193, 215], 'chemicals': [4, 41, 69, 137, 164], 'in': [5, 52, 58, 63, 120, 200, 211, 235, 243], 'commerce': [6], 'which': [7, 64, 145], 'have': [8], 'not': [9], 'been': [10, 56], 'evaluated': [11], 'for': [12, 46, 135, 162, 187, 225], 'potential': [13, 116], 'developmental': [14, 27, 117, 156], 'toxicity': [15, 28], 'is': [16, 33], 'large.': [17], 'Because': [18], 'the': [20, 180, 191], 'time': [21], 'and': [22, 91, 102, 105, 123, 171, 205, 237], 'expense': [23], 'required': [24], 'by': [25], 'conventional': [26, 47, 124, 160, 188, 226], 'tests,': [29], 'an': [30], 'abbreviated': [31], 'assay': [32, 54, 122, 204], 'needed': [34], 'that': [35, 176, 244], 'will': [36], 'preliminarily': [37], 'evaluate': [38], 'otherwise': [39], 'untested': [40, 178], 'to': [42, 95, 107, 208, 240], 'help': [43], 'prioritize': [44], 'them': [45, 216], 'testing.': [48], 'A': [49], 'proposed': [50], 'short‐term': [51], 'vivo': [53], 'has': [55], 'used': [57], 'a': [59, 65, 201, 220], 'series': [60], 'studies': [62], 'total': [66], '60': [68], 'were': [70, 73, 87, 92, 111, 128, 133, 177, 197, 206, 232, 238], 'tested.': [71], 'Some': [72], 'independently': [74], 'tested': [75, 234], 'two': [76], 'or': [77], 'four': [78], 'times': [79], 'each.': [80], 'In': [81], 'this': [82, 121], 'preliminaly': [83], 'test,': [84], 'pregnant': [85], 'mice': [86], 'dosed': [88], 'during': [89], 'mid‐pregnancy': [90], 'then': [93], 'allowed': [94], 'deliver': [96], 'litters.': [97], 'Litter': [98], 'size,': [99], 'birth': [100], 'weight,': [101], 'neonatal': [103], 'growth': [104], 'survival': [106], 'postnatal': [108], 'day': [109], '3': [110], 'recorded': [112], 'as': [113], 'indices': [114], 'toxicity.': [118, 157], 'Results': [119], 'mouse': [125], 'teratology': [126, 203], 'tests': [127], 'generally': [129], 'concordant.': [130], 'Conventional': [131], 'data': [132, 161], 'available': [134], '14': [136], '(ten': [138], 'teratogens,': [139, 148], 'one': [140, 149, 151, 214], 'fetotoxin,': [141, 150], 'three': [142, 163], 'nonteratogens),': [143], '11': [146], '(nine': [147], 'nonteratogen)': [152], 'produced': [153], 'evidence': [154], 'This': [158], 'included': [159], '(ethylene': [165, 217], 'glycol,': [166], 'diethylene': [167], 'glycol': [168, 173, 229], 'dimethyl': [169, 174], 'ether,': [170], 'triethylene': [172], 'ether)': [175, 231], 'before': [179], 'present': [181], 'study.': [182], 'As': [183], 'high': [184, 222], 'priority': [185, 223], 'candidates': [186], 'testing': [189], 'on': [190], 'basis': [192], 'results': [194], 'here,': [195], 'all': [196], 'subsequently': [198, 233], 'studied': [199], 'standard': [202], 'confirmed': [207], 'be': [209, 241], 'teratogenic': [210, 242], 'mice.': [212], 'Additionally,': [213], 'glycol)': [218], 'plus': [219], 'fourth': [221], 'candidate': [224], 'study': [227], '(diethylene': [228], 'monomethyl': [230], 'rats': [236], 'found': [239], 'species.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082981840', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 36}], 'updated_date': '2024-12-17T07:11:21.569570', 'created_date': '2016-06-24'}