Title: Kinetic Measurements of the Turnover Rates of Phenylethylamine and Tryptamine In Vivo in the Rat Brain
Abstract: Abstract: The turnover rates of phenylethylamine and tryptamine have been estimated as their rates of accumulation after inhibition of monoamine oxidase by pargyline and were found to be 1.53 nmol/g/h and 0.24 nmol/g/h, respectively. Rate constants for the substrate activities of these amines towards monoamine oxidase were calculated as 100 h −1 and 150 h −1 , respectively. Tryptamine was found to exhibit a biphasic response to increasing pargyline dosage, demonstrating its dual activity to type B and type A monoamine oxidase, for which two rate constants were obtained, k B =100 h −1 and k A =50 h −1 .
Publication Year: 1980
Publication Date: 1980-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 174
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