Publication Information

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5104, 5118, 5127, 5150, 5174, 5230, 5242, 5270, 5284, 5295, 5329, 5356, 5369, 5455, 5462, 5502, 5508, 5518, 5562, 5571, 5595, 5615, 5638, 5640, 5645, 5735, 5743, 5762, 5789, 5805, 5808, 5821, 5829, 5846, 5867, 5886, 5889, 5929, 5952, 5988, 5997, 6009, 6017, 6019, 6033, 6058], 'd-glucosamine': [7, 226, 442], '6-phosphate': [8, 10, 129, 132, 157, 159, 214, 227, 229, 348, 351, 376, 378, 433, 441, 443, 445, 447, 449, 465, 468, 995, 1147, 1252, 1256, 1327, 1335], 'fromd-fructose': [9, 228], 'using': [11, 230, 470, 792, 1285, 1591, 1726, 1825, 2004, 2078, 2262, 2281, 3292, 4903, 5155, 5183], 'l-glutamine': [12, 231, 2213], 'as': [13, 89, 197, 232, 308, 416, 472, 824, 1434, 1734, 1747, 1828, 2037, 2091, 2169, 3476, 3518, 3650, 3692, 3960, 4248, 4575, 5013, 5441, 5443, 5512, 6003], 'ammonia': [15, 234, 474], 'source.': [16, 235], 'Because': [17, 236, 4533], 'N-acetylglucosamine': [18, 237], 'is': [19, 36, 55, 81, 87, 114, 238, 255, 274, 300, 306, 333, 529, 547, 606, 618, 625, 676, 1149, 1196, 1246, 2011, 2299, 2304, 2342, 2480, 2635, 2864, 2897, 3118, 3170, 3379, 3429, 3528, 3545, 3602, 3703, 3720, 3785, 3873, 3879, 3903, 3941, 4261, 4368, 4413, 4477, 4562, 4618, 4677, 4694, 4707, 4823, 4958, 5040, 5084, 5153, 5168, 5181, 5249, 5737, 5755, 5793, 5815, 5823, 5838, 5873, 5895, 5961, 6048], 'an': [20, 58, 97, 239, 277, 316, 548, 634, 881, 1197, 1218, 1547, 1993, 2333, 2484, 2557, 2721, 2738, 2983, 3043, 3113, 3956, 4336, 4369, 4392, 4423, 4512, 4576, 4777, 5078, 5243, 6049], 'essential': [21, 240, 832], 'building': [22, 241], 'block': [23, 242], 'both': [25, 244, 2918, 3000, 3054, 3123, 3336, 3764, 5563, 6035], 'bacterial': [26, 245, 556], 'cell': [27, 31, 246, 250, 557, 561], 'walls': [28, 247, 558], 'and': [29, 42, 130, 179, 194, 215, 248, 261, 349, 398, 413, 434, 559, 572, 575, 614, 692, 764, 826, 889, 1041, 1144, 1243, 1259, 1274, 1296, 1307, 1340, 1378, 1412, 1452, 1493, 1503, 1519, 1563, 1579, 1597, 1612, 1630, 1650, 1705, 1751, 1784, 1832, 1857, 1875, 1910, 1941, 1977, 1986, 2083, 2118, 2131, 2175, 2183, 2190, 2195, 2198, 2201, 2225, 2240, 2295, 2326, 2436, 2509, 2723, 2784, 2868, 2917, 2921, 3016, 3070, 3197, 3219, 3317, 3347, 3471, 3515, 3522, 3645, 3689, 3696, 3767, 3798, 3805, 3843, 4035, 4172, 4198, 4273, 4287, 4378, 4432, 4572, 4743, 4779, 4874, 4882, 4970, 5005, 5062, 5166, 5204, 5359, 5409, 5438, 5566, 5601, 5691, 5718, 5745, 5747, 5831, 5909, 5958, 5984, 6000, 6021, 6038], 'fungal': [30, 249, 560], 'wall': [32, 251, 562], 'chitin,': [33, 252], 'enzyme': [35, 254, 982, 1088, 2479, 2633, 3330, 4650, 4778, 4902, 5090, 5256, 5955], 'a': [37, 71, 90, 256, 290, 309, 530, 567, 631, 638, 772, 992, 1070, 1286, 1509, 1633, 1653, 2079, 2724, 3119, 3332, 3364, 3585, 4249, 4461, 4517, 4529, 4553, 4619, 4644, 4652, 4780, 4784, 4897, 4971, 5101, 5116, 5267, 5282, 5749, 5832, 5930], 'potential': [38, 257, 568], 'target': [39, 258, 569], 'for': [40, 119, 259, 338, 570, 878, 1193, 1225, 1294, 1351, 1382, 1425, 1495, 1575, 2248, 2564, 2978, 2999, 3178, 3263, 3270, 3289, 3335, 3352, 3501, 3546, 3675, 3721, 3877, 3906, 4339, 4409, 4474, 4551, 4570, 4582, 4586, 4648, 4685, 4716, 4748, 5122, 5201, 5290, 5344, 5365, 5451, 5942, 5993], 'antibacterial': [41, 260, 571, 2325], 'antifungal': [43, 262, 573, 2327], 'agents.': [44, 263, 2328], 'The': [45, 68, 264, 287, 604, 622, 756, 976, 1231, 1459, 1482, 1586, 1618, 1715, 1816, 1848, 1950, 1970, 1997, 2063, 2160, 2288, 2301, 2358, 2710, 3180, 3209, 3249, 3305, 3490, 3524, 3664, 3699, 4469, 4774, 4789, 5172, 5524, 5593, 5635, 5732, 5752, 5818, 5835, 6024], 'most': [46, 265, 1151, 2359], 'potent': [47, 120, 266, 339, 1084, 1152, 1226, 2632, 2838, 3120], 'carbohydrate-based': [48, 267, 902, 1153, 2561, 3175, 6059], 'inhibitor': [49, 93, 147, 268, 312, 366, 1154, 1201, 2260, 3121, 3176, 3436, 3609, 4622], 'GlmS': [51, 80, 95, 178, 270, 299, 314, 397, 565, 598, 675, 879, 1209, 2034, 2209, 2228, 2318, 2511, 2565, 3017, 3189, 3243, 3406, 3878, 3907, 4093, 4245, 4264, 4387, 4472, 4486, 4624, 5646, 5983, 6060], 'reported': [52, 271, 1155, 1300, 1907, 2016, 2302, 3177, 4610, 4641, 4747, 5343, 5364, 5450], 'to': [53, 101, 116, 142, 169, 187, 207, 272, 320, 335, 361, 388, 406, 426, 611, 620, 633, 637, 790, 900, 997, 1013, 1082, 1156, 1220, 1238, 1302, 1348, 1393, 1442, 1488, 1490, 1508, 1570, 1632, 1720, 1821, 1888, 1893, 1903, 1945, 1992, 2125, 2220, 2231, 2235, 2246, 2316, 2344, 2482, 2559, 2630, 2636, 2729, 2736, 2789, 3095, 3104, 3206, 3238, 3247, 3276, 3280, 3341, 3374, 3431, 3481, 3486, 3530, 3535, 3604, 3655, 3660, 3705, 3710, 3781, 3908, 3943, 4066, 4075, 4083, 4252, 4324, 4345, 4351, 4356, 4397, 4415, 4442, 4450, 4466, 4497, 4541, 4627, 4642, 4657, 4770, 4792, 4799, 4993, 5020, 5046, 5055, 5100, 5109, 5178, 5226, 5266, 5275, 5325, 5338, 5445, 5459, 5505, 5515, 5529, 5575, 5598, 5725, 5740, 5748, 5759, 5795, 5826, 5842, 5875, 5913, 5921, 5967, 6013, 6029, 6052], 'date': [54, 273, 1157], '2-amino-2-deoxy-d-glucitol': [56, 131, 216, 275, 350, 435, 444, 1146], '6-phosphate,': [57, 217, 276, 436, 5069], 'analogue': [59, 278, 3114, 4370, 4390, 4615, 5000, 5066, 5332], 'putative': [62, 281, 993, 3216], 'cis-enolamine': [63, 76, 282, 295, 1077, 1215, 3045, 3195, 3217, 3488, 3537, 3662, 3712, 3783], 'intermediate': [64, 77, 196, 283, 296, 415, 775, 996, 1001, 1079, 1216, 1245, 2741, 3046, 3196, 3218, 3784, 4523, 5065, 5331, 5521, 5573, 5606, 6002, 6041], 'formed': [65, 284, 2652], 'during': [66, 285, 776, 2653], 'catalysis.': [67, 286], 'interaction': [69, 288], 'series': [72, 291], 'structurally': [74, 293], 'related': [75, 294], 'analogues': [78, 297, 822, 1212, 2315, 2331, 2641, 2834, 2986, 3192, 3213, 3235, 3408, 5607], 'with': [79, 96, 298, 315, 892, 907, 1037, 1337, 1521, 1546, 1581, 1604, 1643, 1745, 2014, 2320, 2347, 3051, 3245, 4115, 4391, 4484, 4511, 4625, 4651, 4710, 4966, 5115, 5281, 5376, 5665, 5925, 5975], 'described.': [82, 301], 'Although': [83, 302, 2477], 'arabinose': [84, 303, 3315, 3375, 3765, 3796, 4271, 4410, 4686, 4699], 'oxime': [85, 304, 1739, 1817, 1860, 1899, 1954, 2002, 2179, 4366, 4476, 4510, 4636, 4687, 4703, 4726, 4750], '5-phosphate': [86, 305, 1261, 1824, 1861, 1955, 3316, 3319, 3372, 3470, 3473, 3644, 3647, 3766, 3769, 3797, 3800, 4272, 4277, 4367, 4688], 'identified': [88, 307, 1527], 'good': [91, 310], 'competitive': [92, 311, 3240, 4621, 5198], 'inhibition': [98, 317, 1207, 1227, 1959, 2289, 3185, 3222, 3253, 3404, 4322, 4360, 4394, 4419, 4682, 5199], 'constant': [99, 318, 3283, 3414, 3438, 3559, 3587, 3611, 3735, 4323, 4361, 4395, 4683], 'equal': [100, 319, 2219, 4344, 4396, 4465, 4656, 5108, 5274], '1.2': [102, 321, 4398], '(±0.3)': [103, 322], 'mm,': [104, 323, 4399], 'presence': [106, 325], 'amino': [109, 136, 163, 205, 328, 355, 382, 424, 538, 4500, 4513, 4535, 5079, 5176, 5244, 5345, 5371, 5457, 5492, 5525, 5733, 5819, 5869, 5907, 5944, 5977, 6011, 6025], 'function': [110, 137, 164, 182, 329, 356, 383, 401, 883, 2335, 3204, 4381, 4536, 5053, 5080, 5177, 5213, 5245, 5312, 5372, 5458, 5493, 5590, 5792, 5870, 5908, 5945, 5987, 6026, 6047], 'at': [111, 330, 884, 1005, 1428, 1866, 1936, 1974, 2217, 2258, 2336, 3360, 3560, 3736, 4531, 5081, 5246, 5494, 5591], '2-position': [113, 332, 5496], 'shown': [115, 334, 1061, 2728, 3227, 3275, 3494, 3529, 3544, 3668, 3704, 3719], 'be': [117, 336, 1083, 2232, 2988, 3239, 3256, 3277, 4352, 4556, 4723, 4893, 4975, 5003, 5581, 5965, 6053], 'important': [118, 337, 549, 1198, 3351, 4414, 6050], 'inhibition.': [121, 340], 'Comparison': [122, 341], 'binding': [125, 153, 190, 212, 344, 372, 409, 431, 1195, 1239, 3173, 3354, 3369, 4095, 4493, 4543, 4720, 4758, 5010, 5023, 5057, 5105, 5124, 5151, 5179, 5271, 5292, 5340, 5367, 5503, 5507, 5517, 5531, 5585, 5643, 5729, 5809, 5890, 5940, 5996, 6018, 6034], 'affinities': [126, 154, 345, 373, 4721], '2-deoxy-d-glucitol': [128, 347, 446], 'indicates': [133, 160, 352, 379, 3343], 'that': [134, 161, 353, 380, 1062, 2639, 2650, 2716, 2974, 3201, 3344, 3384, 3777, 3901, 3953, 4244, 4263, 4373, 4417, 4471, 4519, 4611, 4724, 5050, 6044], 'contributes': [138, 165, 357, 384, 4537, 5214, 5313, 5497, 5528, 6027], '−4.1': [139, 358, 5314], '(±0.1)': [140, 167, 359, 386], 'kcal/mol': [141, 168, 360, 387, 4540, 5113, 5120, 5218, 5279, 5288, 5317, 5358, 5361, 5447, 5807, 5888], 'free': [144, 171, 209, 363, 390, 428, 3513, 3687, 3773, 3844, 4288, 4311, 4329, 4986, 5102, 5125, 5148, 5228, 5268, 5293, 5327, 5341, 5810, 6015, 6031], 'energy': [145, 172, 210, 364, 391, 429, 4987, 5103, 5126, 5149, 5229, 5269, 5294, 5328, 5504, 5811, 5891, 6016, 6032], 'binding.': [148, 175, 367, 394, 3208, 5232, 5333], 'Similarly,': [149, 368, 5233], 'comparison': [150, 369], '2-deoxy-d-glucose': [156, 375, 448, 1255, 1334], 'andd-glucosamine': [158, 377], '−3.0': [166, 385, 5215], 'product': [174, 193, 393, 412, 1242, 1525, 5060, 5231, 5565, 5999, 6037], 'Interactions': [176, 395], 'between': [177, 396, 4776, 5714, 5905, 5982], '2-amino': [181, 400, 1236, 3203, 3346, 4385, 5052, 5207, 5212, 5311, 5716, 5791, 5986, 6046], 'its': [184, 403, 1822, 3532, 3707, 5989], 'ligands': [185, 404, 4117, 5202, 5374, 5990], 'contribute': [186, 405], 'uniform': [189, 408, 5728, 5995], 'thecis-enolamine': [195, 414, 1244, 3116, 4372, 4443, 4522, 5567, 5572, 5918, 6001], 'evidenced': [198, 417, 6004], 'by': [199, 418, 784, 819, 984, 1210, 1319, 1331, 1342, 1397, 1436, 1450, 1464, 1528, 1601, 1607, 1615, 1742, 1749, 1830, 1908, 1963, 2129, 2273, 2866, 2899, 2926, 3190, 3407, 3446, 3619, 4524, 4808, 4895, 4977, 5074, 5088, 5239, 5254, 5583, 6005], 'similar': [201, 420, 1347, 1902, 2994, 3103, 3279, 3430, 3603, 3833, 3942, 5337, 6007], 'contribution': [202, 421, 1233, 3200, 5015, 5049, 5173, 5368, 5454, 6008], 'group': [206, 425, 1237, 4514, 4807, 4898, 5717, 5734, 5820, 5845, 6012], 'ofd-glucosamine': [213, 432], 'respectively.': [218, 437, 1314, 5209, 5431, 6023], 'glucosamine-6-phosphate': [438, 3001], 'd-fructose': [440], '(l-glutamine:d-fructose-6-phosphate': [452], 'aminotransferase': [453], '(GlmS,1': [454], 'EC': [455], '2.6.1.16))': [456], 'first': [459, 605, 2519], 'step': [460, 2981], 'in': [461, 1064, 1217, 1312, 1373, 1625, 1895, 1957, 2012, 2149, 2165, 2237, 2250, 2293, 2353, 2514, 2778, 3228, 3309, 3325, 3367, 3509, 3683, 3770, 3788, 3837, 4279, 4292, 4332, 4362, 4458, 4689, 4719, 4733, 4757, 4812, 4876, 5009, 5042, 5348, 5611, 5618, 5802, 5883, 5934, 6055], 'hexosamine': [462], 'biosynthesis,': [463], 'convertingd-fructose': [464], '(Fru-6-P)': [466], 'intod-glucosamine': [467], '(GlcN-6-P)': [469, 5061], 'glutamine': [471, 610, 683, 757, 815, 820, 2314, 2355, 3564, 3740, 5971], 'source': [475], '(Scheme': [476, 1015, 3047], '1)': [477], '(1Ghosh': [478], 'S.': [479, 485, 2421, 2440, 2459, 4832, 5478], 'Blumenthal': [480], 'H.J.': [481], 'Davidson': [482], 'E.': [483, 2371, 2423, 2465, 2527, 3966, 4049, 5413, 5621], 'Roseman': [484], 'J.': [486, 661, 721, 920, 951, 966, 1024, 1049, 1179, 1358, 1771, 1790, 1805, 2042, 2096, 2425, 2572, 2603, 2618, 2883, 2905, 2932, 2960, 3025, 3080, 3146, 3297, 3419, 3592, 3816, 3821, 3849, 3854, 3925, 3930, 3969, 3985, 4005, 4023, 4599, 4666, 4847, 4915, 5301, 5398, 5474, 5479], 'Biol.': [487, 952, 1180, 1359, 2043, 2097, 2604, 2749, 2884, 2906, 2933, 3147, 3298, 3420, 3593, 3970, 3986, 4006, 4024, 5302, 5400], 'Chem.': [488, 645, 663, 921, 923, 940, 953, 1026, 1051, 1092, 1168, 1181, 1360, 1772, 1792, 1807, 2044, 2098, 2451, 2573, 2575, 2592, 2605, 2658, 2885, 2907, 2934, 2962, 3027, 3082, 3135, 3148, 3299, 3421, 3460, 3594, 3633, 3823, 3856, 3932, 3971, 3987, 4007, 4025, 4600, 4602, 4667, 4669, 5303, 5481, 5550], '1960;': [489], '235:': [490], '1265-1273Abstract': [491], 'Full': [492, 2889, 2911, 2938, 3975, 3991, 4011, 4029, 4054, 4056, 4137, 4139, 4162, 4164, 4214, 4216, 5681, 5683, 5778, 5780], 'Text': [493, 2890, 2912, 2939, 3976, 3992, 4012, 4030, 4055, 4057, 4138, 4140, 4163, 4165, 4215, 4217, 5682, 5684, 5779, 5781], 'PDF': [494, 2891, 2913, 2940, 3977, 3993, 4013, 4031, 4058, 4141, 4166, 4218, 5685, 5782], 'PubMed': [495, 523, 712, 726, 751, 846, 971, 1122, 1762, 1843, 1921, 2029, 2058, 2112, 2393, 2411, 2431, 2472, 2501, 2548, 2623, 2688, 2766, 2808, 2827, 2876, 2892, 2914, 2941, 2966, 3011, 3065, 3162, 3580, 3756, 3978, 3994, 4014, 4032, 4059, 4110, 4142, 4167, 4187, 4219, 4237, 4304, 4837, 4866, 4934, 4949, 5032, 5142, 5389, 5404, 5426, 5540, 5557, 5630, 5660, 5686, 5706, 5783, 5861], 'Google': [496, 526, 652, 670, 715, 727, 736, 754, 849, 858, 867, 928, 947, 957, 974, 1033, 1058, 1099, 1111, 1125, 1175, 1185, 1364, 1765, 1782, 1799, 1814, 1846, 1924, 2032, 2048, 2061, 2102, 2115, 2144, 2380, 2396, 2414, 2434, 2457, 2475, 2504, 2536, 2551, 2580, 2599, 2609, 2626, 2665, 2677, 2691, 2753, 2769, 2811, 2830, 2879, 2893, 2915, 2942, 2969, 3014, 3034, 3068, 3089, 3142, 3152, 3165, 3303, 3401, 3425, 3467, 3583, 3598, 3640, 3759, 3830, 3863, 3939, 3979, 3995, 4015, 4033, 4062, 4113, 4145, 4170, 4190, 4222, 4240, 4307, 4607, 4674, 4840, 4869, 4937, 4952, 5035, 5145, 5307, 5392, 5407, 5429, 5488, 5543, 5560, 5633, 5663, 5689, 5709, 5786, 5864], 'Scholar,': [497, 511, 653, 716, 728, 737, 850, 859, 929, 948, 958, 1100, 1112, 1126, 1176, 1766, 1800, 2049, 2103, 2381, 2397, 2415, 2581, 2600, 2610, 2666, 2678, 2692, 2754, 2812, 2880, 2943, 3143, 3153, 3980, 3996, 4223, 4841, 4870, 4938, 5393, 5544], '2Badet-Denisot': [498], 'M.-A.': [499, 515, 585, 704, 739, 800, 838, 919, 931, 962, 1046, 1159, 2401, 2571, 2583, 2614, 3126, 3451, 3624, 3886, 4098, 4128, 4153, 4179, 4205, 4229, 4598, 4665, 5648, 5672, 5698, 5769, 5853], 'René': [500, 586, 801, 3887], 'L.': [501, 587, 802, 1130, 2696, 2846, 3888], 'Badet': [502, 588, 659, 743, 803, 916, 936, 963, 1022, 1040, 1047, 1164, 2405, 2448, 2568, 2588, 2615, 3023, 3078, 3131, 3456, 3566, 3629, 3742, 3889, 4102, 4129, 4154, 4180, 4206, 4230, 4595, 4662, 5652, 5673, 5699, 5770, 5854], 'B.': [503, 589, 655, 660, 718, 744, 804, 917, 937, 964, 1018, 1023, 1048, 1165, 1324, 2383, 2406, 2449, 2491, 2538, 2569, 2589, 2616, 3019, 3024, 3074, 3079, 3132, 3457, 3570, 3630, 3746, 3890, 4103, 4130, 4155, 4181, 4207, 4231, 4596, 4663, 5132, 5653, 5674, 5700, 5771, 5855], 'Bull.': [504, 590, 805, 3891], 'Soc.': [505, 591, 664, 806, 922, 1027, 1052, 1773, 1793, 1808, 2574, 2760, 2802, 3028, 3083, 3824, 3857, 3892, 3933, 4601, 4668, 5482], 'Chim.': [506, 592, 807, 3893], 'Fr.': [507, 593, 808, 3894], '1993;': [508, 594, 733, 809, 855, 3895], '130:': [509, 595, 810, 3896], '249-255Google': [510, 596, 811, 3897], '3Massière': [512], 'F.': [513, 658, 702, 742, 836, 935, 1021, 1163, 2388, 2404, 2447, 2496, 2543, 2587, 3022, 3077, 3130, 3455, 3575, 3628, 3751, 4101, 5137, 5651], 'Badet-Denisot': [514, 703, 837, 918, 961, 1045, 2570, 2613, 3447, 3620, 3882, 4127, 4152, 4178, 4204, 4228, 4597, 4664, 5671, 5697, 5768, 5852], 'Cell.': [516, 705, 839, 1104, 2670], 'Mol.': [517, 706, 840, 1103, 2669, 2748, 5399], 'Life': [518, 707, 841], 'Sci.': [519, 708, 842, 2762, 2804, 4183, 4233, 4830, 5702, 5857], '1998;': [520, 709, 843, 4134, 4159, 4211, 5678, 5775], '54:': [521, 710, 844], '205-222Crossref': [522, 711, 845], 'Scopus': [524, 650, 668, 713, 752, 847, 945, 972, 1031, 1056, 1097, 1109, 1123, 1173, 1763, 1780, 1797, 1812, 1844, 1922, 2030, 2059, 2113, 2142, 2378, 2394, 2412, 2432, 2455, 2473, 2502, 2534, 2549, 2597, 2624, 2663, 2675, 2689, 2767, 2809, 2828, 2877, 2967, 3012, 3032, 3066, 3087, 3140, 3163, 3399, 3465, 3581, 3638, 3757, 3828, 3861, 3937, 4060, 4111, 4143, 4168, 4188, 4220, 4238, 4305, 4838, 4867, 4935, 4950, 5033, 5143, 5390, 5405, 5427, 5486, 5541, 5558, 5631, 5661, 5687, 5707, 5784, 5862], '(168)': [525, 714, 848], 'Scholar).': [527, 597, 671, 755, 812, 868, 975, 1034, 1186, 1365, 1815, 1847, 1925, 2033, 2062, 2116, 2145, 2476, 2552, 2627, 2709, 2770, 2831, 2859, 2970, 3166, 3304, 3426, 3584, 3599, 3641, 3760, 3831, 3864, 4191, 4308, 4887, 4953, 5036, 5146, 5308, 5489, 5634, 5787, 5865], 'GlcN-6-P': [528, 1014, 2075, 4036, 4147, 5073, 5128, 5222, 5666, 5736, 6020], 'precursor': [531], 'uridine': [533], 'diphospho-N-acetylglucosamine': [534], 'from': [535, 630, 1264, 1981, 2285, 2733, 3039, 3415, 3565, 3588, 3741, 4521, 4899, 4907, 5072, 5237, 5871, 5917], 'which': [536, 617, 686, 697, 770, 795, 829, 2010, 2341, 4485, 4676, 4814, 5070, 5235, 5722], 'other': [537, 673, 1269, 3950, 5349], 'sugar-containing': [539], 'molecules': [540], 'are': [541, 817, 1080, 1299, 2640, 2651, 2837, 2924, 3226, 3350, 3474, 3495, 3648, 3669, 4064, 5336, 5608, 5991], 'derived.': [542], 'One': [543, 2628, 4714], 'these': [545, 2330, 2774, 2985, 3264, 3338, 4194, 5797, 5877], 'products,N-acetylglucosamine,': [546], 'constituent': [550], 'peptidoglycan': [553], 'layer': [554, 1530], 'chitin.': [563], 'Accordingly,': [564], 'offers': [566], 'agents': [574], 'has': [576, 760, 2309, 2555, 2996, 4797], 'attracted': [577], 'interest': [579, 4822], 'several': [581, 1211, 3191, 3212], 'research': [582], 'groups': [583, 4820], '(2Badet-Denisot': [584, 799, 3885], 'two': [600, 679, 5878], 'coupled': [601, 1706, 1892], 'enzymatic': [602, 797], 'reactions.': [603], 'hydrolysis': [608, 689, 758], 'yield': [612, 4335, 4516], 'glutamate': [613, 888], 'nascent': [615], 'ammonia,': [616], 'transferred': [619], 'Fru-6-P.': [621, 3248, 4258], 'second': [623], 'reaction': [624, 759], 'isomerization': [627, 700], 'Fru-6-P': [629, 2521, 3835, 3872, 3920, 4094, 4617, 4628, 5642], 'ketose': [632, 2725], 'aldose,': [635], 'corresponding': [636, 1823, 3221, 4078], 'Heyns': [639], 'rearrangement': [640], '(4Kort': [641], 'M.J.': [642], 'Adv.': [643, 731, 853, 862, 2744], 'Carbohydr.': [644, 1757, 1838, 1916, 2024], 'Biochem.': [646, 746, 967, 1105, 2619, 2671, 4105, 5626, 5655], '1970;': [647, 2873], '25:': [648, 4947], '311-349Crossref': [649], '(79)': [651], '5Golinelli-Pimpaneau': [654], 'Le': [656, 740, 1019, 2386, 2402, 2445, 2494, 2541, 3020, 3075, 3573, 3749, 4099, 5135, 5649], 'Goffic': [657, 741, 1020, 2387, 2403, 2446, 2495, 2542, 3021, 3076, 3574, 3750, 4100, 5136, 5650], 'Am.': [662, 1025, 1050, 1791, 1806, 3026, 3081, 3822, 3855, 3931, 5480], '1989;': [665, 1028, 2824, 3029, 3084, 5029], '111:': [666, 1029, 3030, 3085], '3029-3034Crossref': [667, 1030, 3031, 3086], '(45)': [669, 1032, 3033, 3088], 'Like': [672], 'amidotransferases,': [674], 'organized': [677], 'into': [678, 4802], 'domains:': [680], 'NH2-terminal': [682, 767, 788, 894, 2349], 'amidotransferase': [684, 2356, 5957, 5972], 'domain,': [685, 696], 'glutamine,': [691, 1068], 'COOH-terminal': [694], '(3Massière': [701, 835], '6Mei': [717], 'Zalkin': [719], 'H.': [720, 730, 852, 1561, 2367, 2419, 2461, 2523, 4880], 'Bacteriol.': [722], '1990;': [723, 2408, 5627], '172:': [724], '3512-3514Crossref': [725], '7Zalkin': [729, 851], 'Enzymol.': [732, 854, 863, 2138, 2745], '66:': [734, 856], '203-309PubMed': [735, 857], '8Denisot': [738], 'Arch.': [745, 4104, 5654], 'Biophys.': [747, 1117, 2373, 2467, 2529, 2683, 4106, 5656], '1991;': [748, 2452, 4107, 5657], '288:': [749, 4108, 5658], '225-230Crossref': [750, 4109, 5659], '(42)': [753, 2060, 2114, 4112, 5662], 'been': [761, 905, 2310, 2556, 2727, 2997, 4119, 4798, 5363, 5449], 'studied': [762], 'extensively': [763], 'utilizes': [765], 'cysteine': [768, 789, 833, 895, 2350], 'thiol,': [769], 'forms': [771, 1988, 3313, 3480, 3654, 3775, 3794, 3847, 4291], 'γ-glutamyl': [773], 'thioester': [774], 'reaction.': [778], 'This': [779, 1203, 1498, 3377, 3427, 3600, 4560, 4693, 4888, 5037, 5098, 5264], 'catalytic': [780, 3945], 'role': [781, 5614], 'was': [782, 1329, 1371, 1391, 1409, 1419, 1423, 1432, 1448, 1455, 1462, 1479, 1486, 1500, 1506, 1588, 1622, 1718, 1733, 1740, 1818, 1961, 2007, 2035, 2070, 2076, 2089, 2229, 2244, 3274, 4422, 4640], 'confirmed': [783], 'conversion': [785], 'alanine': [791], 'site-directed': [793, 874, 4904], 'mutagenesis': [794, 4905], 'abolished': [796], 'activity': [798, 979, 2065, 2319, 2777, 3244], 'In': [813, 1035, 2204, 3049, 3110, 3167, 3231], 'general,': [814], 'amidotransferases': [816], 'inactivated': [818], 'affinity': [821, 3334, 4470, 4483, 4494, 4544, 4585, 4647, 4796, 4813, 5011, 5941], 'such': [823, 2841, 3390, 3959, 4552], '6-diazo-5-oxo-l-norleucine': [825], '6-chloro-5-oxo-l-norleucine': [827], '(chloroketone),': [828], 'alkylate': [830], 'residue': [834, 2351], '9Buchanan': [860], 'J.M.': [861, 1553, 2902], '1973;': [864, 4008, 5401, 5423], '39:': [865], '91-183PubMed': [866], 'Indeed,': [869], 'many': [870], 'active': [873], 'irreversible': [875], 'inactivators': [876, 2361, 2507], 'developed': [877, 1545], 'contain': [880], 'electrophilic': [882, 2334], 'γ-position': [886, 2338], 'react': [890, 2345], 'irreversibly': [891, 2346], 'residue.': [896], 'More': [897], 'recently,': [898], 'attempts': [899], 'develop': [901], 'inhibitors': [903, 1085, 2163, 2562, 2634, 2839, 3241, 3265, 5001], 'have': [904, 1060, 2362, 2726, 2785, 3091, 3899, 4118, 4242, 4609, 4643, 5362, 5448], 'made': [906, 2245], 'hope': [909], 'developing': [911, 2324, 2631], 'more': [912, 4731], 'specificity': [913], '(10Corizzi': [914, 2566, 4593, 4660], 'V.': [915, 2567, 4594, 4661], 'Commun.': [924, 2576, 4603, 4670], '1992;': [925, 2469, 2577, 4604, 4671], ':': [926, 1778, 2578, 4605, 4672], '189-190Crossref': [927, 2579, 4606, 4673], '11Badet-Denisot': [930, 2582], 'Leriche': [932, 1160, 2584, 3127, 3452, 3625], 'C.': [933, 960, 1044, 1161, 1325, 2585, 2612, 2957, 3128, 3453, 3626], 'Massière': [934, 1162, 2586, 3129, 3454, 3627], 'Bioorg.': [938, 1166, 2450, 2590, 3133, 3458, 3631], 'Med.': [939, 1167, 2591, 2961, 3134, 3459, 3632], 'Lett.': [941, 1169, 2593, 3136, 3461, 3634], '1995;': [942, 1170, 2055, 2109, 2594, 3137, 3462, 3635, 4051, 5483], '5:': [943, 1095, 1120, 1171, 2595, 2661, 2686, 3138, 3463, 3636], '815-820Crossref': [944, 1172, 2596, 3139, 3464, 3637], '(35)': [946, 1174, 2598, 2968, 3141, 3466, 3639], '12Bearne': [949, 1177, 2601, 3144], 'S.L.': [950, 1178, 1357, 2041, 2051, 2095, 2105, 2602, 3145, 3296, 3418, 3591, 5300], '1996;': [954, 1053, 1182, 1361, 2045, 2099, 2606, 3149, 3300, 3422, 3595, 5304], '271:': [955, 1183, 1362, 2046, 2100, 2607, 3150, 3301, 3423, 3596, 5305], '3052-3057PubMed': [956, 1184, 1363, 2047, 2101, 2608, 3151, 3302, 3424, 3597, 5306], '13Leriche': [959, 2611], 'Eur.': [965, 2617], '1997;': [968, 2620], '245:': [969, 2621], '418-422Crossref': [970, 2622], '(17)': [973, 2625], 'ketose/aldose': [977], 'isomerase': [978, 2863, 2896, 2920, 3962, 4018, 5720, 5959], 'proceeds': [983], 'abstraction': [985, 2732, 3038], 'C1': [988], 'pro-R': [989], 'hydrogen': [990, 2791, 3097, 4505, 5738, 5757, 5799, 5824, 5840, 5879, 5902, 5932], 'fructosimine': [994], 'form': [998, 3870, 4076, 4431, 4456], 'acis-enolamine': [999], 'reactive': [1000, 1078, 2648, 5064, 5330, 5520, 5605, 6040], 'that,': [1002], 'upon': [1003], 'reprotonation': [1004], 'Re': [1007], 'face': [1008], 'C2,': [1010], 'gives': [1011, 4460], 'rise': [1012, 5724], '2)': [1016], '(5Golinelli-Pimpaneau': [1017, 3018, 3073], 'accord': [1036, 3050], 'this': [1038, 1229, 3052, 3290, 4363, 4389, 4490, 4638, 4717], 'mechanism,': [1039, 3053], 'co-workers': [1042, 4199], '(14Leriche': [1043], '118:': [1054], '1797-1798Crossref': [1055], '(29)': [1057], 'Scholar)': [1059, 1143, 1568, 1783, 2435, 3015, 3035, 3069, 3090, 3898, 3940, 4114, 4241, 4608, 5408, 5561, 5664, 5690, 5710], 'GlmS,': [1063], 'absence': [1066, 2516, 2780, 5076, 5241], 'displays': [1069, 3331, 4473], 'low': [1071, 3333], 'phosphoglucoisomerase': [1072], 'activity.': [1073], 'Analogues': [1074], 'expected': [1081, 5794, 5874], '(15Wolfenden': [1089, 2655], 'R.': [1090, 1102, 1114, 1128, 2053, 2107, 2369, 2417, 2463, 2525, 2656, 2668, 2680, 2694, 2759, 2801, 2844, 2871, 2931, 3820, 3853, 3929, 5027, 5395], 'Acc.': [1091, 2657], 'Res.': [1093, 1758, 1839, 1917, 2025, 2427, 2659], '1972;': [1094, 2660, 3396], '10-18Crossref': [1096, 2662], '(546)': [1098, 2664], '16Wolfenden': [1101, 2667], '1974;': [1106, 2672, 2886], '3:': [1107, 2140, 2673, 4052], '111-207Crossref': [1108, 2674], '(87)': [1110, 2676], '17Wolfenden': [1113, 2679], 'Annu.': [1115, 2681, 5624], 'Rev.': [1116, 2682, 5625], 'Bioeng.': [1118, 2684], '1976;': [1119, 2685, 5537], '271-306Crossref': [1121, 2687], '(381)': [1124, 2690], '18Wolfenden': [1127, 2693], 'Frick': [1129, 2695, 2845], 'Page': [1131, 2697, 2847], 'M.I.': [1132, 2698, 2848], 'Williams': [1133, 2699, 2849], 'A.': [1134, 2700, 2816, 2850, 3968, 4124, 4149, 4175, 4201, 4225, 4833, 4872, 5417, 5668, 5694, 5765, 5849], 'Enzyme': [1135, 2701, 2851], 'Mechanisms.': [1136, 2702, 2852], 'Royal': [1137, 2703, 2853], 'Society': [1138, 2704, 2854], 'Chemistry,': [1140, 2706, 2856], 'London1987:': [1141, 2707, 2857], '97-122Google': [1142, 2708, 2858], 'indeed,': [1145], '(GlcNol-6-P)': [1148], '(11Badet-Denisot': [1158, 3125, 3450, 3623], 'Identification': [1187], 'those': [1189, 1349], 'structural': [1190, 1223, 3484, 3533, 3658, 3708, 3779, 4768], 'elements': [1191], 'necessary': [1192], 'tight': [1194, 3353], 'part': [1199], 'design.': [1202], 'paper': [1204], 'describes': [1205, 3183], 'attempt': [1219, 2243], 'probe': [1221], 'requirements': [1224], 'enzyme.': [1230], 'energetic': [1232, 3199, 5453], 'determined.': [1247], 'd-Arabinose,': [1248], 'd-arabinose': [1249, 1744, 1859, 2171, 2178], '5-phosphate,': [1250, 2172, 2180, 2187], '2-amino-2-deoxy-d-glucose': [1251], '(d-glucosamine': [1253], '6-phosphate),': [1254], '(dGlc-6-P),': [1257], 'd-Fru-6-P,': [1258], 'd-ribose': [1260, 2186], 'were': [1262, 1271, 1283, 1317, 1526, 1577, 1648, 1886, 1927, 1989, 2122, 2147, 2168, 2256, 2271, 2291, 3236, 4313, 4745], 'purchased': [1263], 'Sigma': [1265], 'Chemical': [1266, 1291], 'Company.': [1267], 'All': [1268], 'chemicals': [1270], 'analytical': [1272], 'grade': [1273], 'used': [1275, 1956, 2164, 5041], 'without': [1276], 'further': [1277], 'purification.': [1278], 'NMR': [1279, 1662, 1697, 1851, 1905, 1968, 2006], 'spectra': [1280, 1298], '(13C,': [1281], '31P)': [1282], 'obtained': [1284], 'Bruker': [1287], 'AC': [1288], '250F': [1289], 'spectrometer.': [1290], 'shifts': [1292], '(δ)': [1293], '13C': [1295, 1661], '31P': [1297, 1696, 1850], 'relative': [1301, 1991, 3340, 3373, 4739, 4992, 5574], 'deuterium': [1304], 'lock': [1305], 'signal': [1306], 'external': [1308], 'H3PO4': [1309], '(85%': [1310], 'w/v': [1311], 'D2O),': [1313], 'Elemental': [1315, 1731], 'analyses': [1316], 'performed': [1318], 'Canadian': [1320], 'Microanalytical': [1321], 'Service': [1322], 'Ltd.,': [1323], '2-Deoxy-d-glucitol': [1326], '(dGlcol-6-P)': [1328], 'synthesized': [1330, 1856], 'reduction': [1332, 3366], '(dGlc-6-P)': [1336], 'sodium': [1338, 1538], 'borohydride': [1339, 1386], 'purified': [1341, 2036], 'ion-exchange': [1343], 'chromatography': [1344, 1531], 'following': [1345], 'procedures': [1346, 2127], 'outlined': [1350, 3519, 3693], 'preparation': [1353, 2069], 'GlcNol-6-P': [1355, 3169, 3271, 3342, 4173, 4571, 5238, 5296, 5321, 5692, 5822, 5872], '(12Bearne': [1356, 2040, 2094, 3295, 3417, 3590, 5299], 'dGlc-6-P': [1366, 1395, 5814], '(250': [1367], 'mg,': [1368], '0.868': [1369], 'mmol)': [1370, 1390], 'dissolved': [1372], '10': [1374, 1383, 1626], 'ml': [1375, 1627], 'water': [1377, 1629, 5750, 5753, 5833, 5836], 'cooled': [1379, 1456], 'on': [1380, 1414, 1457, 1532, 2312, 4193, 4506, 4984, 5373], 'ice': [1381], 'min.': [1384, 1402], 'Sodium': [1385], '(0.750': [1387], 'g,': [1388, 1658], '19.83': [1389], 'added': [1392], 'solution': [1396, 1408, 1422, 1441, 1483, 1499, 3510, 3684, 4295, 4333, 4459], 'small': [1398], 'portions': [1399], 'over': [1400, 1472], '20': [1401], 'During': [1403], 'NaBH4': [1405, 1447, 1461], 'addition,': [1406, 2205, 3111], 'stirred': [1410, 1424, 1494], 'vigorously': [1411], 'held': [1413], 'ice.': [1415, 1458], 'After': [1416], 'addition': [1418, 1466], 'complete,': [1420], '1': [1426, 1496, 1737, 2157, 2796], 'h': [1427], 'room': [1429, 1491], 'temperature.': [1430], 'Reduction': [1431], 'complete': [1433], 'indicated': [1435], 'inability': [1438], 'reduce': [1443], "Fehling's": [1444], 'reagent.': [1445], 'Undissolved': [1446], 'removed': [1449, 1590, 4824, 5018], 'filtration,': [1451], 'filtrate': [1454, 1505], 'remaining': [1460, 1619], 'destroyed': [1463], 'dropwise': [1465], '6': [1468], 'm': [1469, 4963], 'acetic': [1470], 'acid': [1471, 1549], '30': [1473], 'min': [1474], 'until': [1475], 'final': [1477, 2068], 'pH': [1478, 1541, 2154], 'approximately': [1480, 3363, 3803, 4400, 4538, 4557, 4563, 5498], '4.': [1481], '(25': [1484], 'ml)': [1485], 'allowed': [1487], 'come': [1489], 'temperature': [1492], 'h.': [1497], 'then': [1501, 1589, 1819], 'filtered,': [1502], 'applied': [1507, 1631], 'Dowex': [1510, 1634, 1727], '50': [1511, 1635, 1728], '(H+': [1512], 'form)': [1513], 'column': [1514, 1637], '(1.5': [1515, 1638], '×': [1516, 1639, 2211], '47': [1517, 1640], 'cm)': [1518, 1641], 'eluted': [1520, 1642], 'water.': [1522, 1644], 'Fractions': [1523, 1572, 1645], 'containing': [1524, 1646, 2156, 4426, 5205], 'thin': [1529], 'cellulose': [1533], '(99%': [1534], 'EtOH,': [1535], 'n-BuOH,': [1536], '0.15m': [1537], 'citrate': [1539], 'buffer,': [1540, 2153], '4.0;': [1542], '10:1:6': [1543], 'v/v/v)': [1544], 'iron-sulfosalicylic': [1548], 'spray': [1550], 'reagent': [1551], '(19Clark': [1552], 'Switzer': [1554], 'R.L.': [1555], 'Experimental': [1556], 'Biochemistry.': [1557, 2054, 2108, 2389, 2407, 2497, 2544, 2823, 2872, 3007, 3061, 3158, 3576, 3752, 4300, 4945, 5138, 5385, 5422, 5536], '2nd': [1558], 'Ed.': [1559, 5552], 'W.': [1560, 4879], 'Freeman': [1562, 4881], 'Co.,': [1564, 4883], 'San': [1565], 'Francisco1977:': [1566], '167Google': [1567], 'sensitive': [1569], 'phosphates.': [1571], 'testing': [1573], 'positive': [1574], 'phosphate': [1576, 2120, 2152], 'pooled': [1578], 'diluted': [1580], '0.50': [1582], 'volume': [1583], 'methanol.': [1585], 'solvent': [1587], 'rotary': [1592, 1616], 'evaporation': [1593], '(⩽': [1594], '37': [1595], '°C)': [1596], 'freed': [1598], 'borate': [1600], 'repeated': [1602], 'treatment': [1603], 'methanol': [1605, 1611], 'followed': [1606], 'removal': [1608], 'methylborate': [1613], 'ester': [1614], 'evaporation.': [1617], 'clear': [1620], 'syrup': [1621], 'taken': [1623], 'up': [1624], '(H+form)': [1636], 'dGlcol-6-P': [1647, 5894], 'combined': [1649], 'lyophilized': [1651], 'yielding': [1652], 'hygroscopic': [1654, 1723], 'glassy': [1655], 'powder': [1656], '(0.1953': [1657], '78%': [1659], 'yield).': [1660], '(62.896': [1663], 'MHz,': [1664, 1699], 'D2O)': [1665, 1700], 'δ': [1666, 1701], '38.00': [1667], '(s,': [1668, 1671, 1683, 1694], 'C2),': [1669], '61.36': [1670], 'C1),': [1672], '69.18': [1673], '(d,': [1674], 'J': [1675, 1709], 'C,': [1676, 1687], 'P': [1677, 1688, 1711, 1871, 1880], '=': [1678, 1689, 1712, 1872, 1881, 3441, 3614, 4631, 5093, 5163, 5187, 5220, 5259, 5319, 5467], '4.77': [1679], 'Hz,': [1680, 1691], 'C6),': [1681], '69.43': [1682], 'C3),': [1684], '72.77': [1685], '(d,J': [1686], '7.63': [1690], 'C5),': [1692], '75.03': [1693], 'C4);': [1695], '(101.26': [1698], 'decoupled': [1702], '1.93': [1703, 1707], '(s)': [1704], '(t,': [1708], 'H,': [1710, 1870, 1879], '5.72': [1713], 'Hz).': [1714, 1883], 'disodium': [1716], 'salt': [1717, 1725], 'converted': [1719, 1820], 'less': [1722, 4402, 4480, 4565, 4679], 'monocyclohexylammonium': [1724], '(cyclohexylammonium': [1729], 'form).': [1730], 'analysis': [1732, 2276, 4891], 'follows.': [1735], 'C18H41O8N2P(345.38)Calculated:C41.73%H8.19%N4.06%P8.97%Found:C40.63%H8.12%N3.79%P8.96%ANALYSIS': [1736], 'd-Arabinose': [1738], 'prepared': [1741], 'treating': [1743], 'hydroxylamine': [1746], 'described': [1748, 1829, 2038, 2092, 2128, 2998], 'Finch': [1750, 1831, 1909], 'Merchant': [1752, 1755, 1769, 1833, 1836, 1911, 1914, 2022], '(20Finch': [1753, 1834, 1912, 2020], 'P.': [1754, 1768, 1835, 1913, 2021, 2385, 2493, 2540, 3572, 3748, 4855, 4857, 4923, 4925, 5134, 5415], 'Z.': [1756, 1770, 1837, 1915, 2023], '1979;': [1759, 1840, 1918, 2026, 2935], '76:': [1760, 1841, 1919, 2027, 5402], '225-232Crossref': [1761, 1842, 1920, 2028], '(5)': [1764, 1845, 1923, 2031], '21Finch': [1767], 'Perkin': [1774], 'Trans.': [1775, 2758, 2800], 'I.': [1776, 3230, 4132, 4157, 4209, 5476, 5676, 5773], '1975;': [1777, 2750, 2908], '1682-1686Crossref': [1779], '(52)': [1781], 'Hockett': [1785], 'et': [1786, 3448, 3567, 3621, 3743, 3883, 4591], 'al.': [1787, 3449, 3568, 3622, 3744, 3884, 4592], '(22Hockett': [1788], 'R.C.': [1789, 1802, 4043], '1935;': [1794], '57:': [1795], '2265-2268Crossref': [1796], '(9)': [1798], '23Hockett': [1801], 'Maynard': [1803], 'C.W.': [1804], '1939;': [1809], '61:': [1810], '2111-2115Crossref': [1811], '(11)': [1813], 'hexokinase-catalyzed': [1826], 'phosphorylation': [1827], 'proton-coupled': [1849], 'spectrum': [1852], 'enzymatically': [1855], 'isolated': [1858], 'showed': [1862], 'broad': [1863], 'triplets': [1864], 'centered': [1865], '5.74': [1867], 'ppm': [1868, 1877, 1976, 1979], '(J': [1869, 1878], '7.3': [1873], 'Hz)': [1874], '4.90': [1876], '4.4': [1882], 'These': [1884, 5334], 'signals': [1885], 'assigned': [1887], 'phosphorus': [1890], 'nuclei': [1891], 'H-5a,5b': [1894], 'E': [1897, 1985, 2000, 4742], 'andZ': [1898], 'phosphate,': [1900], 'respectively,': [1901, 2009], 'the31P': [1904], 'assignments': [1906], 'There': [1926], 'also': [1928, 5250, 5756, 5839], 'five': [1929], 'very': [1930, 3278], 'minor': [1931], 'peaks': [1932], '(≤': [1933], '7%)': [1934], 'present': [1935, 3181, 3308, 3324, 3508, 3682, 4331, 4457, 4691, 5044], '3.58,': [1937], '−4.74,': [1938], '−4.92,': [1939], '−9.07,': [1940], '−9.29': [1942], 'possibly': [1943], 'due': [1944, 4496], 'contaminating': [1946], 'phosphoenolpyruvate': [1947], 'or': [1948, 2647, 3868, 4906, 5604], 'nucleotides.': [1949], 'actual': [1951, 3875, 4315], 'concentration': [1952, 2161, 3562, 3738, 3810, 4327, 4453], 'ofd-arabinose': [1953], 'studies': [1960], 'determined': [1962, 2003, 2077, 2292, 3288, 3444, 3617], 'integration': [1964], '1H': [1967, 2005], 'spectrum.': [1969], 'well': [1971], 'resolved': [1972], 'doublets': [1973], '7.59': [1975], '6.95': [1978], 'arising': [1980], 'H-1': [1982], 'Z': [1987, 4735], 'integrated': [1990], 'internal': [1994], 'pyrazine': [1995], 'standard.': [1996], 'ratio': [1998, 2017], 'toZ': [2001], '85:15,': [2008], 'agreement': [2013], '83:17': [2019], 'earlier': [2039], '24Bearne': [2050, 2104], 'Wolfenden': [2052, 2106, 2930, 5026], '34:': [2056, 2110], '11515-11520Crossref': [2057, 2111], 'specific': [2064, 2563, 5901], '0.25': [2071], 'unit/mg': [2072], 'protein.': [2074], 'modified': [2080, 4972, 5004], 'Morgan-Elson': [2081], 'procedure,': [2082], 'validity': [2085], 'assay': [2088], 'established': [2090], 'previously': [2093], 'Inorganic': [2117], 'organic': [2119], 'assays': [2121, 2167, 2207], 'conducted': [2123, 2148, 4894], 'according': [2124], 'Leloir': [2130], 'Cardini': [2132, 2135], '(25Leloir': [2133], 'L.F.': [2134], 'C.E.': [2136, 2947], 'Methods': [2137], '1957;': [2139], '840-850Crossref': [2141], '(219)': [2143], 'Assays': [2146], '0.1m': [2150], 'potassium': [2151], '7.5,': [2155], 'mm': [2158, 4659], 'EDTA.': [2159], 'follows:': [2170], '4.6,': [2173], '9.1,': [2174, 2188], '13.7': [2176], 'mm;': [2177, 2185, 2192, 2197], '3.1,': [2181], '6.2,': [2182], '9.4': [2184], '18.2,': [2189], '27.3': [2191], 'dGlcol-6-P,': [2193, 5234], '25.0': [2194], '50.0': [2196], 'dGlc-6-p,': [2199], '57.2': [2200], '171.7': [2202], 'mm.': [2203, 2227, 4468], 'contained': [2208], '(6.7': [2210], '10−3unit/ml),': [2212], '(15': [2214], 'mm),': [2215], 'andd-Fru-6-P': [2216], 'concentrations': [2218, 2261, 2264], '0.45,': [2221], '0.89,': [2222], '1.79,': [2223], '4.47,': [2224], '8.94': [2226], 'found': [2230, 3237], 'relatively': [2233], 'insensitive': [2234], 'changes': [2236, 2249, 5008], 'ionic': [2238, 2251], 'strength,': [2239], 'therefore': [2241, 5580], 'no': [2242, 3904, 4353], 'correct': [2247], 'strength.': [2252], 'Complete': [2253], 'Michaelis-Menten': [2254, 2279], 'plots': [2255, 2280], 'constructed': [2257], 'all': [2259, 2772, 3232, 3505, 3679], 'd-Fru-6-P': [2266], 'given': [2267], 'above.': [2268, 3109], 'Kinetic': [2269], 'data': [2270], 'analyzed': [2272], 'nonlinear': [2274], 'regression': [2275], 'program': [2283], 'Enzymekinetics(1990)': [2284], 'Trinity': [2286], 'Software.': [2287], 'constants': [2290, 3223, 3254, 3262, 5200], 'triplicate,': [2294], 'average': [2297], 'value': [2298, 3269, 3428, 3433, 3543, 3601, 3606, 3718, 4343, 4407, 4449, 4464, 4550, 4561, 4569, 4655, 5117, 5283], 'reported.': [2300], 'error': [2303], 'S.D.': [2306], 'Much': [2307], 'attention': [2308], 'focused': [2311], 'utilizing': [2313], 'inhibit': [2317], 'goal': [2322], 'Typically,': [2329], 'possess': [2332], 'glutamate,': [2340], 'believed': [2343, 2481, 4065], 'located': [2352], 'domain.': [2357], 'effective': [2360], 'beenN': [2363], '3-fumaroyl-l-2,3-diaminopropanoate': [2364], 'derivatives': [2365, 2438], '(26Chmara': [2366, 2522], 'Andruszkiewicz': [2368, 2462, 2524], 'Borowski': [2370, 2422, 2464, 2526], 'Biochim.': [2372, 2466, 2528], 'Acta.': [2374, 2468, 2530], '1985;': [2375, 2531, 3825, 3858, 3934, 4863, 4931], '870:': [2376, 2532], '357-366Crossref': [2377, 2533], '(51)': [2379, 2535], '27Badet': [2382], 'Vermoote': [2384, 2492, 2539, 3571, 3747, 5133], '1988;': [2390, 2498, 2545, 3577, 3753, 5139], '27:': [2391, 2429, 2499, 2546, 2964, 3578, 3754, 5140], '2282-2287Crossref': [2392, 2500, 2547, 3579, 3755, 5141], '(65)': [2395, 2503, 2550, 3582, 3758, 5144], '28Kucharczyk': [2398], 'N.': [2399, 2444], 'Denisot': [2400], '29:': [2409], '3668-3676Crossref': [2410], '(40)': [2413], '29Andruszkiewicz': [2416], 'Chmara': [2418, 2460], 'Milewski': [2420], 'Int.': [2424, 5551], 'Peptide': [2426], '1986;': [2428, 4946], '449-453Crossref': [2430], '(39)': [2433], '2-amino-3-((N-halomethyl)amino)propanoate': [2437], '(30Auvin': [2439], 'Cochet': [2441], 'O.': [2442], 'Kucharczyk': [2443], '19:': [2453], '143-151Crossref': [2454], '(14)': [2456], 'Scholar,31Milewski': [2458], '1115:': [2470], '225-229Crossref': [2471], '(15)': [2474], 'follow': [2483], 'ordered': [2485], 'Bi': [2486, 2487], 'kinetic': [2488], 'mechanism': [2489, 2995, 3958], '(27Badet': [2490, 3569, 3745, 5131], 'Scholar),': [2505, 2894, 2916, 4016, 4034, 4063, 4146, 4171, 4675, 5430], 'glutamine-like': [2506], 'bind': [2508], 'inactivate': [2510], 'effectively': [2512], 'even': [2513], 'substrate': [2520, 2735, 3041, 3876, 4074, 4969, 4973], 'Scholar,27Badet': [2537], 'Recently,': [2553, 4085], 'there': [2554, 3902, 4349], 'effort': [2558], 'identify': [2560], 'approach': [2629, 4791, 4957, 5039], 'design': [2637, 6057], 'compounds': [2638, 3339], 'either': [2643, 2734, 4900], 'transition': [2645, 2976, 2990, 4990, 4998, 5021, 5463, 5602], 'states': [2646], 'intermediates': [2649], 'catalysis': [2654, 5619], 'mechanisms': [2711], 'phosphorylated': [2713], 'sugar': [2714], 'isomerases': [2715, 2842, 3107, 3952], 'catalyze': [2717, 3909, 4067, 4253, 4266], 'interconversion': [2719], 'aldose': [2722], 'involve': [2730, 4783], 'proton': [2731, 3037], 'give': [2737, 5723], 'enzyme-bound': [2739, 3044], 'cis-enediol': [2740], '(32Rose': [2742], 'I.A.': [2743, 2756, 2798, 3006, 3060, 3157, 4004, 4299], 'Relat.': [2746], 'Areas': [2747], '43:': [2751], '491-517PubMed': [2752], '33Rose': [2755], 'Philos.': [2757, 2799], 'Lond-Biol.': [2761, 2803], '1981;': [2763, 2805, 4834], '293:': [2764, 2806], '131-143Crossref': [2765, 2807], '(43)': [2768, 2810], 'Virtually': [2771], 'enzymes': [2775, 3124, 3383, 5378, 5596], 'show': [2776, 3389, 5711], 'metal': [2782], 'ions': [2783], 'exchange': [2786, 3092], '(to': [2787, 3093], 'solvent)': [2788, 3094], 'intramolecular': [2790, 3096], 'transfer': [2792, 3098], 'ratios': [2793, 3099], 'greater': [2794, 3100], 'than': [2795, 3101, 4403, 4481, 4566, 4680], '(33Rose': [2797], '34Farber': [2813], 'G.K.': [2814], 'Glasfeld': [2815], 'Tiraby': [2817], 'G.': [2818, 4039, 4126, 4151, 4177, 4203, 4227, 4861, 4929, 5670, 5696, 5767, 5851], 'Ringe': [2819], 'D.': [2820], 'Petsko': [2821, 5622], 'G.A.': [2822, 5623], '28:': [2825], '7289-7297Crossref': [2826], '(109)': [2829], 'As': [2832], 'expected,': [2833], 'thecis-enediol': [2836], '(18Wolfenden': [2843], 'For': [2860, 5352, 5432], 'example,': [2861, 5353], 'triose-phosphate': [2862], 'inhibited': [2865, 2898, 2925], '2-phosphoglycolate': [2867], '2-phosphoglycolohydroxamate': [2869], '(35Wolfenden': [2870], '9:': [2874], '3404-3407Crossref': [2875], '(47)': [2878], '36Collins': [2881], 'K.D.': [2882], '249:': [2887], '136-142Abstract': [2888], 'glucose-6-phosphate': [2895, 3961], '5-phosphoarabinoate': [2900], '(37Chirgwin': [2901], 'Noltmann': [2903, 3983, 4021], 'E.A.': [2904, 3394, 3984, 4022], '250:': [2909], '7272-7276Abstract': [2910], 'arabinose-5-phosphate': [2919], 'ribose-5-phosphate': [2922], 'epimerase': [2923], '4-phosphoerythronate': [2927], '(38Woodruff': [2928], 'W.W.': [2929], '254:': [2936], '5866-5867Abstract': [2937], '39Bigham': [2944], 'E.C.': [2945], 'Gragg': [2946], 'Hall': [2948], 'W.R.': [2949, 2953], 'Kelsey': [2950], 'J.E.': [2951], 'Mallory': [2952], 'Richardson': [2954], 'D.C.': [2955], 'Benedict': [2956], 'Ray': [2958], 'P.H.': [2959], '1984;': [2963], '717-726Crossref': [2965], 'To': [2971], 'extent': [2973], 'state': [2977, 2991, 4991, 4999, 5022, 5464, 5578, 5603], 'rate-determining': [2980], 'resembles': [2982], 'enediol,': [2984], 'may': [2987, 4265, 4722, 4892, 4974, 5002], 'considered': [2989], 'analogues.': [2992], 'A': [2993], 'deaminase': [3002, 3056, 4037], '(40Midelfort': [3003, 3057, 4296], 'C.F.': [3004, 3058, 3155, 4297], 'Rose': [3005, 3059, 3156, 4003, 4298], '1977;': [3008, 3062, 3159, 4301, 5554], '16:': [3009, 3063, 3160, 4302, 5555], '1590-1596Crossref': [3010, 3064, 3161, 4303], '(48)': [3013, 3067, 3164, 4306, 5391], 'where': [3036, 5161, 5191], 'yields': [3042], '2).': [3048], '1,': [3102], 'phosphosugar': [3106, 3951], 'discussed': [3108], 'GlcNol-6-P,': [3112, 6022], 'intermediate,': [3117], '40Midelfort': [3154], 'fact,': [3168], 'tightest': [3172], 'reversible': [3174], 'GlmS.': [3179], 'work': [3182, 5045], 'Escherichia': [3187], 'coli': [3188], 'makes': [3205, 5054], 'ligand': [3207, 3291, 4781, 4909], 'structures': [3210, 4088, 5594, 5637], 'their': [3220, 3483, 3657, 3771, 3778, 4767], '(K': [3224, 3439, 3612, 4629, 5091, 5257], 'i)': [3225], 'Table': [3229, 3761], 'cases,': [3233], 'respect': [3246, 4626], 'values': [3250, 3493, 3500, 3667, 3674, 4964, 5335, 5355, 5440], 'should': [3255], 'accurate': [3257], 'estimates': [3258], 'dissociation': [3261, 3282, 3437, 3610], 'since': [3266], 'theK': [3267, 4567], 'i': [3268, 3440, 3492, 3499, 3542, 3613, 3666, 3673, 3717, 4342, 4406, 4448, 4463, 4549, 4568, 4630, 4654, 5092, 5160, 5258], '(19': [3272], 'μm)': [3273, 3443, 3616], '34': [3285], '(±7)': [3286], 'μm': [3287], 'protection': [3293], 'experiments': [3294], 'carbonyl': [3306, 3774, 3845, 4289, 4330, 5828], 'functions': [3307, 3349, 5346], 'open': [3311], 'chain': [3312, 3479, 3653, 4080], 'ribose': [3318, 3371, 3472, 3646, 3768, 3799, 4274], 'mimic': [3320], 'double': [3322, 4376], 'bond': [3323, 4377, 5933], 'cis-enolamine.': [3327], 'That': [3328], '1-hydroxyl': [3348], 'GlcNol-6-P.': [3356, 4488, 5523], 'Changing': [3357], 'stereochemistry': [3359], 'C2': [3361, 4507], 'causes': [3362], '4-fold': [3365], '5-phosphate.': [3376, 4275, 4411], 'observation': [3378], 'not': [3380, 3880, 4708, 4746], 'unexpected': [3381, 4695], 'because': [3382, 3912], 'isomerize': [3385], 'carbohydrate': [3386, 3506, 3680, 4073], 'substrates': [3387], 'generally': [3388], 'stereochemical': [3391], 'discrimination': [3392], '(41Noltmann': [3393], 'Enzymes.': [3395], '6:': [3397, 4135, 4160, 4212, 5679, 5776], '271-354Crossref': [3398], '(112)': [3400], 'Scholar).Table': [3402], 'ICompetitive': [3403], 'enolamine': [3411], 'intermediatea': [3412], 'Inhibition': [3413, 3558, 3586, 3734], 'Bearne': [3416, 3589], '25': [3442, 3615], 'independently': [3445, 3618], 'Scholar).b': [3468], 'Arabinose': [3469, 3643, 4276, 4365], 'represented': [3475, 3649], 'straight': [3478, 3652, 4079], 'highlight': [3482, 3531, 3656, 3706], 'similarity': [3485, 3534, 3659, 3709, 3780, 4769], 'intermediate.': [3489, 3663, 4444, 4589, 4713, 4773, 5568], 'K': [3491, 3498, 3541, 3665, 3672, 3716, 4341, 4405, 4462, 4653, 5165], 'apparent': [3497, 3671, 4393], 'combination': [3503, 3677], 'species': [3507, 3681, 3812, 4081, 5465], '(cyclic,': [3511, 3685], 'acyclic,': [3512, 3686], 'aldehyde,': [3514, 3688], 'hydrate': [3516, 3690, 4285], 'forms)': [3517, 3691], 'under': [3520, 3694], '"Results': [3521, 3695], 'Discussion."c': [3523], 'syn': [3525, 3700], '(E)': [3526, 3555, 3701, 3730], 'isomer': [3527, 3702], 'intermediate;': [3538, 3713], 'however,': [3539, 3714], 'equilibrium': [3548, 3723, 4424], 'mixture': [3549, 3724, 4420, 4425], 'anti': [3551, 3726], '(Z)': [3552, 3727, 4430], '(15%)': [3553, 3728], 'andsyn': [3554, 3729], '(85%)': [3556, 3731], 'isomers.d': [3557], 'saturating': [3561, 3737], 'b': [3642], 'Discussion."': [3697], 'c': [3698], 'isomers.': [3732], 'd': [3733], 'I': [3762], 'shows': [3763], 'acyclic': [3772, 3793, 3869], 'so': [3776], 'evident.': [3786], 'However,': [3787, 3949, 4348, 4634], 'neutral': [3789, 4293], 'aqueous': [3790, 4294], 'solution,': [3791], 'only': [3801, 4525, 5085, 5251], 'comprise': [3802], '2.4': [3804], '0.6%': [3806], 'total': [3809, 5939], 'present,': [3813], 'respectively': [3814], '(42Pierce': [3815, 3848], 'Serianni': [3817, 3850, 3926], 'A.S.': [3818, 3851, 3927], 'Barker': [3819, 3852, 3928], '107:': [3826, 3859, 3935], '2448-2456Crossref': [3827, 3860, 3936], '(75)': [3829, 3862, 3938], 'Under': [3832], 'conditions,': [3834], 'exists': [3836, 4278, 4730], 'β-furanose': [3839, 4283], '(81.1%),': [3840], 'α-furanose': [3841, 4281], '(16.1%),': [3842], '(2.2%)': [3846], 'Whether': [3865], 'cyclic': [3867, 4072, 4257], 'known.': [3881], 'argued': [3900], 'need': [3905], 'ring': [3910, 3917, 4068, 4254, 4268], 'opening': [3911, 3918, 4069, 4255, 4269], 'spontaneous': [3914], 'rate': [3915, 3946], '(18–21': [3921], 's−1;': [3922], 'Ref.': [3923], '42Pierce': [3924], '(19–23': [3947], 's−1).': [3948], 'proceed': [3954], 'via': [3955], 'enolization': [3957], '(43Salas': [3963], 'M.': [3964, 5421], 'Vinuela': [3965], 'Sols': [3967], '1965;': [3972], '240:': [3973], '561-568Abstract': [3974], '44Dyson': [3981], 'J.E.D.': [3982], '1968;': [3988, 4026], '243:': [3989, 4027, 5030], '1401-1414Abstract': [3990], '45Schray': [3997], 'K.J.': [3998], 'Benkovic': [3999, 4001], 'S.J.': [4000], 'P.A.': [4002], '248:': [4009], '2219-2224Abstract': [4010], 'mannose-6-phosphate': [4017], '(46Gracy': [4019], 'R.W.': [4020], '5410-5419Abstract': [4028], '(47Oliva': [4038], 'Fontes': [4040], 'M.R.': [4041], 'Garratt': [4042], 'Altamirano': [4044], 'M.M.': [4045], 'Calcagno': [4046], 'M.L.': [4047], 'Horjales': [4048], 'Structure.': [4050, 4133, 4158, 4210, 5677, 5774], '1323-1332Abstract': [4053], '(72)': [4061], 'prior': [4082], 'deprotonation.': [4084], 'crystal': [4087, 4195, 5636], 'complexes': [4090, 5639], 'domain': [4096, 5644, 5721, 5973], '(8Denisot': [4097, 5647], 'different': [4116], 'reported,': [4120], 'including': [4121], 'Glu-6-P': [4122], '(48Teplyakov': [4123, 4148, 4200, 5667, 5764], 'Obmolova': [4125, 4150, 4176, 4202, 4226, 5669, 5695, 5766, 5850], 'Polikarpov': [4131, 4156, 4208, 5675, 5772], '1047-1055Abstract': [4136, 4161, 4213, 5680, 5777], '(93)': [4144, 4169, 4221, 5688, 5785], '(49Teplyakov': [4174, 5693, 5848], 'Protein': [4182, 4232, 4877, 5701, 5856], '1999;': [4184, 4234, 5703, 5858], '8:': [4185, 4235, 5704, 5859], '596-602Crossref': [4186, 4236, 5705, 5860], '(77)': [4189, 4239, 5708, 5863], 'Based': [4192], 'structures,': [4196], 'Teplyakov': [4197], '49Teplyakov': [4224], 'proposed': [4243], 'uses': [4246], 'His-504': [4247], 'general': [4250, 4790], 'base': [4251], 'Thus': [4259, 5210, 5309], 'it': [4260, 4801, 5513, 5963], 'possible': [4262], '(57.3%),': [4282], '(40.4%),': [4284], '(2.2%),': [4286], '(⩽0.2%)': [4290], 'If': [4309], 'aldehyde': [4312], 'inhibitory': [4316, 4761], 'species,': [4317], 'adjustment': [4318], 'observed': [4321, 4359, 4408, 4684, 4795, 4965, 5121, 5289, 5727, 5812, 5892], 'reflect': [4325, 4451], 'would': [4334, 4515, 4555], 'upper': [4337, 4580], 'limit': [4338, 4581], '17': [4346], 'μm.': [4347, 4559], 'seems': [4350], 'convincing': [4354], 'reason': [4355], 'adjust': [4357], 'manner.': [4364], 'contains': [4374], 'hydroxyl': [4380, 5589], 'but': [4382], 'lacks': [4383], 'function.': [4386, 5978], 'binds': [4388, 4487], '7-fold': [4401], 'It': [4412], 'note': [4416], 'tested': [4421], '15%': [4427], 'theanti': [4429], '85%': [4433], 'syn(E)': [4436], 'form,': [4437], 'latter': [4439, 4956, 5038], 'being': [4440], 'analogous': [4441], 'Adjusting': [4445], 'apparentK': [4447], 'theE': [4455], '1.0': [4467], 'still': [4478], '53-fold': [4479], 'Is': [4489], 'lack': [4491], 'principally': [4495], 'missing': [4499], 'function?': [4501], 'Replacement': [4502], 'compound': [4518, 4554, 4639], 'differs': [4520, 5071, 5236], 'substitution': [4527], 'nitrogen': [4530], 'C1.': [4532, 5592], '4.1': [4539, 5887], '(see': [4545], 'below),': [4546], 'expectedK': [4548], '1.3': [4558], '15-fold': [4564], 'might': [4573], 'serve': [4574], 'estimate': [4577], "enzyme's": [4584], 'actualcis-enolamine': [4588], 'Corizzi': [4590], 'non-isosteric': [4613], 'phosphonate': [4614, 4706, 4729], 'poor': [4620], '2.5': [4632], 'mm).': [4633, 5097, 5263], 'much': [4645], 'higher': [4646], '0.2': [4658], 'slightly': [4678], 'work.': [4692], 'because,': [4696], 'unlike': [4697], 'derived': [4700], 'oxime,': [4701], 'isosteric': [4709], 'putativecis-enolamine': [4712], 'explanation': [4715], 'difference': [4718, 4756], 'predominately': [4732], 'form.': [4736], 'Unfortunately,': [4737], 'amounts': [4740], 'Zforms': [4744], 'phosphonate.': [4753], 'Despite': [4754], 'affinities,': [4759], 'nature': [4762], 'oximes': [4765], 'reflects': [4766], 'proposedcis-enolamine': [4772], 'interactions': [4775, 5617, 5713, 5881, 5904, 5981], 'always': [4782], 'substantial': [4785], 'number': [4786], 'groups.': [4788], 'understanding': [4793], 'dissect': [4800], 'contributions': [4804], 'each': [4806], 'measuring': [4809], 'change': [4811, 5914], 'results': [4815], 'when': [4816, 5813, 5893, 5915], 'one': [4817], '(50Jencks': [4825], 'W.P.': [4826], 'Proc.': [4827], 'Natl.': [4828], 'Acad.': [4829], 'U.': [4831], '78:': [4835], '4046-4050Crossref': [4836], '(848)': [4839], '51Fersht': [4842], 'A.R.': [4843, 4911], 'Shi': [4844, 4912], 'J.-P.': [4845, 4913], 'Knill-Jones': [4846, 4914], 'Lowe': [4848, 4916], 'D.M.': [4849, 4853, 4917, 4921], 'Wilkinson': [4850, 4918], 'A.J.': [4851, 4919], 'Blow': [4852, 4920], 'Brick': [4854, 4922], 'Carter': [4856, 4924], 'Waye': [4858, 4926], 'M.M.Y.': [4859, 4927], 'Winter': [4860, 4928], 'Nature.': [4862, 4930], '314:': [4864, 4932], '235-238Crossref': [4865, 4933], '(993)': [4868, 4936], '52Fersht': [4871], 'Structure': [4873], 'Mechanism': [4875], 'Science.': [4878, 5028], 'New': [4884], 'York1999:': [4885], '340-345Google': [4886], 'type': [4889], 'removing': [4896], '(51Fersht': [4910], '53Street': [4939], 'I.P.': [4940], 'Armstrong': [4941], 'C.R.': [4942], 'Withers': [4943], 'S.G.': [4944], '6021-6027Crossref': [4948], '(188)': [4951], 'When': [4954], 'used,': [4959], 'k': [4961], 'cat/K': [4962, 5469, 5471], 'natural': [4968], 'compared': [4976, 5114, 5280], 'calculating': [4978], 'effect': [4980], 'modification': [4983], 'ground': [4995, 5577], 'state.': [4996], 'Alternatively,': [4997], 'subsequent': [5007], 'interpreted': [5012], 'moiety': [5019, 6051], '(54Kati': [5024], 'W.M.': [5025], '1591-1593Crossref': [5031], '(58)': [5034], 'assess': [5047], '(GlcNol-6-P).': [5067], '2-Deoxy-d-glucose': [5068], '2-position,': [5083, 5248], 'weakly': [5086, 5253], 'bound': [5087, 5252], '46': [5094], '±': [5095, 5111, 5216, 5261, 5277, 5286, 5315], '7': [5096], 'corresponds': [5099, 5265], '(ΔG': [5106, 5129, 5272, 5297], 'dGlc-6-P)': [5107, 5225], '−1.90': [5110], '0.09': [5112], '−4.85': [5119], 'GlcN-6-P)': [5130], '2The': [5147], '(ΔG)': [5152], 'calculated': [5154, 5182], 'equation': [5157, 5185], 'ΔG': [5158, 5221, 5224, 5320, 5323], '=RTlnK': [5159], 'T': [5162], '310.2': [5164], 'R': [5167], 'gas': [5170], 'constant.': [5171], '(ΔΔG)': [5180], 'ΔΔG': [5186, 5354], '−RTln(Ki': [5188], 'H/Ki': [5189], 'NH2)': [5190], 'Ki': [5192], 'H': [5193], 'andKi': [5194], 'NH2': [5195], 'represent': [5196], 'lacking': [5203], 'function,': [5208, 5526], '0.1': [5217, 5316], '(ΔΔG': [5219, 5318, 5466], '−': [5223, 5322], '15': [5260], '2': [5262], 'dGlcol-6-P)': [5273, 5324], '−2.59': [5276], '0.08': [5278], '−6.70': [5285], '0.02': [5287], 'GlcNol-6-P)': [5298], 'energies': [5342], 'participating': [5347], 'protein-ligand': [5350], 'interactions.': [5351], '−3.4': [5357], '−6.7': [5360], 'interacting': [5375], 'phenylalanyl-tRNA': [5379], 'synthetase': [5380, 5411], '(55Santi': [5381], 'D.V.': [5382], 'Danenberg': [5383], 'P.V.': [5384], '1971;': [5386], '10:': [5387], '4813-4820Crossref': [5388], '56Mulivor': [5394], 'Rappaport': [5396], 'H.P.': [5397], '123-134Crossref': [5403], '(23)': [5406], 'isoleucyl-tRNA': [5410], '(57Holler': [5412], 'Rainey': [5414], 'Orme': [5416], 'Bennett': [5418], 'E.L.': [5419], 'Calvin': [5420], '12:': [5424], '1150-1159Crossref': [5425], '(41)': [5428], 'aminoglycoside': [5434], '3′-phosphotransferases,': [5435], 'types': [5436], 'Ia': [5437], 'IIa,': [5439], 'large': [5442], '−6': [5444], '−11': [5446], 'stabilization': [5461, 5570], '−RTln((k': [5468], 'm)H/(k': [5470], 'm)NH2))': [5472], '(58Roestamadji': [5473], 'Grapsas': [5475], 'Mobashery': [5477], '117:': [5484], '11060-11069Crossref': [5485], '(69)': [5487, 5632], 'Thus,': [5490, 5979], 'same': [5500], 'amount': [5501], 'product,': [5510], 'GlcN-6-P,': [5511], 'does': [5514], 'analogue,': [5522, 6042], 'therefore,': [5527], 'theuniform': [5530], '(59Albery': [5532], 'W.J.': [5533, 5546], 'Knowles': [5534, 5547], 'J.R.': [5535, 5548], '15:': [5538], '5631-5640Crossref': [5539], '(592)': [5542], '60Albery': [5545], 'Angew.': [5549], 'Engl.': [5553], '285-293Crossref': [5556], '(146)': [5559], 'Selective': [5569], 'must': [5579], 'caused': [5582], 'another': [5584], 'determinant,': [5586], 'likely': [5587], 'complexed': [5597], 'substrates,': [5599], 'products,': [5600], 'often': [5609], 'useful': [5610], 'delineating': [5612], 'enzyme-ligand': [5616], '(61Lolis': [5620], '59:': [5628], '597-630Crossref': [5629], '(Fig.': [5730], '1).': [5731], 'bonded': [5739, 5758, 5825, 5841], 'carbonyls': [5742], 'Val-399': [5744, 5830], 'Ala-602,': [5746], 'molecule.': [5751, 5834], 'molecule': [5754, 5837], 'γ-carboxylate': [5761], 'Glu-488': [5763], 'Removal': [5788, 5866], 'disrupt': [5796, 5876], 'three': [5798], 'bonds': [5800], 'resulting': [5801, 5882], 'loss': [5804, 5885], '3.0': [5806], 'ligand.': [5817, 5897], 'ε-amino': [5844], 'Lys-603': [5847], 'bonding': [5880, 5903], 'Therefore,': [5898], 'although': [5899], 'protein': [5911], 'appear': [5912], 'going': [5916], 'intermediate-enzyme': [5919], 'complex': [5920, 5924], 'product-enzyme': [5923, 5936], 'concomitant': [5927], 'gain': [5928], 'single': [5931], 'complex,': [5937], 'remains': [5946], 'roughly': [5947], 'unchanged.': [5948], 'Once': [5949], 'structure': [5951], 'whole': [5954], '(glutamine': [5956], 'domains)': [5960], 'solved,': [5962], 'will': [5964], 'interesting': [5966], 'see': [5968], 'if': [5969], 'interacts': [5974], 'responsible': [5992], 'significantly': [6028], 'indicating': [6043], 'included': [6054], 'inhibitors.': [6061]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082807029', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}], 'updated_date': '2024-12-11T07:53:14.160530', 'created_date': '2016-06-24'}