Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2082617936', 'doi': 'https://doi.org/10.1074/jbc.m710181200', 'title': 'Human Cytomegalovirus Regulates Bioactive Sphingolipids', 'display_name': 'Human Cytomegalovirus Regulates Bioactive Sphingolipids', 'publication_year': 2008, 'publication_date': '2008-07-22', 'ids': {'openalex': 'https://openalex.org/W2082617936', 'doi': 'https://doi.org/10.1074/jbc.m710181200', 'mag': '2082617936', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18644793', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2533798'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m710181200', 'pdf_url': 'http://www.jbc.org/article/S0021925820525301/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820525301/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5104441208', 'display_name': 'Nicholas Machesky', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicholas J. Machesky', 'raw_affiliation_strings': ['Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011896823', 'display_name': 'Guojuan Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guojuan Zhang', 'raw_affiliation_strings': ['Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011439618', 'display_name': 'Bindu Raghavan', 'orcid': 'https://orcid.org/0000-0002-1819-5251'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bindu Raghavan', 'raw_affiliation_strings': ['Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032925941', 'display_name': 'Pete Zimmerman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pete Zimmerman', 'raw_affiliation_strings': ['Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091696771', 'display_name': 'Samuel Kelly', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130701444', 'display_name': 'Georgia Institute of Technology', 'ror': 'https://ror.org/01zkghx44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130701444']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Samuel L. Kelly', 'raw_affiliation_strings': ['School of Biology , Georgia Institute of Technology , Atlanta, Georgia, 30332'], 'affiliations': [{'raw_affiliation_string': 'School of Biology , Georgia Institute of Technology , Atlanta, Georgia, 30332', 'institution_ids': ['https://openalex.org/I130701444']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002672605', 'display_name': 'Alfred H. Merrill', 'orcid': 'https://orcid.org/0000-0002-6673-968X'}, 'institutions': [{'id': 'https://openalex.org/I130701444', 'display_name': 'Georgia Institute of Technology', 'ror': 'https://ror.org/01zkghx44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130701444']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alfred H. Merrill', 'raw_affiliation_strings': ['School of Biology , Georgia Institute of Technology , Atlanta, Georgia, 30332'], 'affiliations': [{'raw_affiliation_string': 'School of Biology , Georgia Institute of Technology , Atlanta, Georgia, 30332', 'institution_ids': ['https://openalex.org/I130701444']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037591262', 'display_name': 'W. James Waldman', 'orcid': 'https://orcid.org/0000-0001-7986-8539'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W. James Waldman', 'raw_affiliation_strings': ['Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001837381', 'display_name': 'James R. Van Brocklyn', 'orcid': 'https://orcid.org/0009-0005-9714-1428'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James R. Van Brocklyn', 'raw_affiliation_strings': ['Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037336291', 'display_name': 'Joanne Trgovcich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joanne Trgovcich', 'raw_affiliation_strings': ['Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The Ohio State University, Columbus, Ohio 43210 and the', 'institution_ids': ['https://openalex.org/I52357470']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.407, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.927721, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '283', 'issue': '38', 'first_page': '26148', 'last_page': '26160'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Signalling and Metabolism in Health and Disease', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Signalling and Metabolism in Health and Disease', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10981', 'display_name': 'Epidemiology and Management of Cytomegalovirus Infection', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13415', 'display_name': 'Lysosomal Calcium Signaling in Physiology and Pathology', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sphingolipid', 'display_name': 'Sphingolipid', 'score': 0.97870976}, {'id': 'https://openalex.org/keywords/sphingosine-kinase-1', 'display_name': 'Sphingosine kinase 1', 'score': 0.48586506}, {'id': 'https://openalex.org/keywords/sphingosine-kinase', 'display_name': 'Sphingosine Kinase', 'score': 0.482601}, {'id': 'https://openalex.org/keywords/lactosylceramide', 'display_name': 'Lactosylceramide', 'score': 0.4777124}], 'concepts': [{'id': 'https://openalex.org/C61705674', 'wikidata': 'https://www.wikidata.org/wiki/Q410395', 'display_name': 'Sphingolipid', 'level': 2, 'score': 0.97870976}, {'id': 'https://openalex.org/C2777700496', 'wikidata': 'https://www.wikidata.org/wiki/Q7576797', 'display_name': 'Sphingosine kinase', 'level': 5, 'score': 0.8674408}, {'id': 'https://openalex.org/C2778703144', 'wikidata': 'https://www.wikidata.org/wiki/Q46298', 'display_name': 'Sphingosine', 'level': 3, 'score': 0.86530375}, {'id': 'https://openalex.org/C2777851122', 'wikidata': 'https://www.wikidata.org/wiki/Q424213', 'display_name': 'Ceramide', 'level': 3, 'score': 0.7715241}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7017823}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6288963}, {'id': 'https://openalex.org/C180899940', 'wikidata': 'https://www.wikidata.org/wiki/Q117982', 'display_name': 'Lipid signaling', 'level': 3, 'score': 0.5189926}, {'id': 'https://openalex.org/C61322309', 'wikidata': 'https://www.wikidata.org/wiki/Q423143', 'display_name': 'Sphingomyelin', 'level': 3, 'score': 0.50540066}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.49674112}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.49540055}, {'id': 'https://openalex.org/C2777550365', 'wikidata': 'https://www.wikidata.org/wiki/Q14913834', 'display_name': 'Sphingosine kinase 1', 'level': 5, 'score': 0.48586506}, {'id': 'https://openalex.org/C2776596873', 'wikidata': 'https://www.wikidata.org/wiki/Q418267', 'display_name': 'Sphingosine-1-phosphate', 'level': 4, 'score': 0.48552275}, {'id': 'https://openalex.org/C2910328161', 'wikidata': 'https://www.wikidata.org/wiki/Q3215908', 'display_name': 'Lactosylceramide', 'level': 3, 'score': 0.4777124}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.45592642}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.40473467}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.37756488}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.26826918}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.1602464}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.14096674}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.07146925}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.06967345}], 'mesh': [{'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015967', 'descriptor_name': 'Gene Expression Regulation, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013107', 'descriptor_name': 'Sphingolipids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017781', 'descriptor_name': 'Genes, Immediate-Early', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013107', 'descriptor_name': 'Sphingolipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m710181200', 'pdf_url': 'http://www.jbc.org/article/S0021925820525301/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2533798', 'pdf_url': 'https://europepmc.org/articles/pmc2533798?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533798', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18644793', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m710181200', 'pdf_url': 'http://www.jbc.org/article/S0021925820525301/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 73, 'referenced_works': ['https://openalex.org/W1496933864', 'https://openalex.org/W1535205259', 'https://openalex.org/W180035021', 'https://openalex.org/W1836679973', 'https://openalex.org/W1890314278', 'https://openalex.org/W1964826500', 'https://openalex.org/W1966075057', 'https://openalex.org/W1966553763', 'https://openalex.org/W1968306248', 'https://openalex.org/W1985430829', 'https://openalex.org/W1987630665', 'https://openalex.org/W1991324453', 'https://openalex.org/W1991558659', 'https://openalex.org/W1991575691', 'https://openalex.org/W1993449698', 'https://openalex.org/W1996192399', 'https://openalex.org/W1996688582', 'https://openalex.org/W2001317930', 'https://openalex.org/W2003147114', 'https://openalex.org/W2005017965', 'https://openalex.org/W2008386567', 'https://openalex.org/W2018729128', 'https://openalex.org/W2019284105', 'https://openalex.org/W2022589671', 'https://openalex.org/W2022770236', 'https://openalex.org/W2024106968', 'https://openalex.org/W2027429767', 'https://openalex.org/W2028067246', 'https://openalex.org/W2036179437', 'https://openalex.org/W2036222948', 'https://openalex.org/W2037956917', 'https://openalex.org/W2043112660', 'https://openalex.org/W2047231993', 'https://openalex.org/W2051391805', 'https://openalex.org/W2053310582', 'https://openalex.org/W2053674100', 'https://openalex.org/W2056899647', 'https://openalex.org/W2057229979', 'https://openalex.org/W2057272534', 'https://openalex.org/W2060043285', 'https://openalex.org/W2061404129', 'https://openalex.org/W2061846827', 'https://openalex.org/W2071600103', 'https://openalex.org/W2073829786', 'https://openalex.org/W2075468442', 'https://openalex.org/W2077215651', 'https://openalex.org/W2079377885', 'https://openalex.org/W2085488090', 'https://openalex.org/W2086571585', 'https://openalex.org/W2087433596', 'https://openalex.org/W2088304077', 'https://openalex.org/W2095291794', 'https://openalex.org/W2096273281', 'https://openalex.org/W2097302710', 'https://openalex.org/W2100041813', 'https://openalex.org/W2103212167', 'https://openalex.org/W2108091182', 'https://openalex.org/W2108352126', 'https://openalex.org/W2109032735', 'https://openalex.org/W2114739240', 'https://openalex.org/W2114741940', 'https://openalex.org/W2118692187', 'https://openalex.org/W2141700993', 'https://openalex.org/W2141921458', 'https://openalex.org/W2142084214', 'https://openalex.org/W2145402824', 'https://openalex.org/W2150592919', 'https://openalex.org/W2159421712', 'https://openalex.org/W2168360212', 'https://openalex.org/W2170308653', 'https://openalex.org/W2170525563', 'https://openalex.org/W2412623747', 'https://openalex.org/W4313377005'], 'related_works': ['https://openalex.org/W3106125263', 'https://openalex.org/W2897589411', 'https://openalex.org/W2889205449', 'https://openalex.org/W2762149298', 'https://openalex.org/W2356739021', 'https://openalex.org/W2111942396', 'https://openalex.org/W2084654786', 'https://openalex.org/W2071515061', 'https://openalex.org/W1983263867', 'https://openalex.org/W114681587'], 'abstract_inverted_index': {'Sphingolipids': [0], 'are': [1, 189], 'present': [2, 162], 'in': [3, 55, 85, 126, 198], 'membranes': [4], 'of': [5, 32, 53, 66, 79, 90, 117, 129, 139, 155], 'all': [6], 'eukaryotic': [7], 'cells.': [8, 119], 'Bioactive': [9], 'sphingolipids': [10, 69, 188], 'also': [11, 106], 'function': [12], 'as': [13, 21], 'signaling': [14, 34, 46], 'molecules': [15], 'that': [16, 96, 122, 164, 185, 201], 'regulate': [17], 'cellular': [18, 33], 'processes': [19], 'such': [20], 'proliferation,': [22], 'migration,': [23], 'and': [24, 70, 77, 88, 101, 131, 146, 169, 178], 'apoptosis.': [25], 'Human': [26], 'cytomegalovirus': [27], '(HCMV)': [28], 'exploits': [29], 'a': [30, 108, 114, 195, 199], 'variety': [31], 'pathways': [35, 47], 'to': [36, 112], 'promote': [37], 'its': [38], 'own': [39], 'replication.': [40, 204], 'However,': [41], 'whether': [42], 'HCMV': [43, 82, 123], 'modulates': [44], 'lipid': [45], 'is': [48], 'an': [49, 137], 'essentially': [50], 'unexplored': [51], 'area': [52], 'research': [54], 'virus-host': [56], 'cell': [57, 187], 'interactions.': [58], 'In': [59], 'this': [60], 'study,': [61], 'we': [62, 161], 'examined': [63], 'the': [64, 67, 71, 75, 94], 'accumulation': [65, 87], 'bioactive': [68], 'enzymes': [72], 'responsible': [73], 'for': [74], 'biosynthesis': [76], 'degradation': [78], 'these': [80, 182], 'lipids.': [81], 'infection': [83, 124, 193], 'results': [84, 125], 'increased': [86, 127], 'activity': [89, 172], 'sphingosine': [91, 98, 170], 'kinase': [92, 171], '(SphK),': [93], 'enzyme': [95], 'generates': [97], '1-phosphate': [99, 103], '(S1P)': [100], 'dihydrosphingosine': [102, 145], '(dhS1P).': [104], 'We': [105, 120], 'utilized': [107], 'mass': [109], 'spectrometry': [110], 'approach': [111], 'generate': [113], 'sphingolipidomic': [115], 'profile': [116], 'HCMV-infected': [118], 'show': [121], 'levels': [128], 'dhS1P': [130, 147], 'ceramide': [132], 'at': [133, 149], '24': [134], 'h,': [135], 'suggesting': [136], 'enhancement': [138], 'de': [140, 156, 165], 'novo': [141, 157, 166], 'sphingolipid': [142, 158, 167], 'synthesis.': [143, 159], 'Subsequently': [144], 'decrease': [148], '48': [150], 'h': [151], 'consistent': [152], 'with': [153, 194], 'attenuation': [154], 'Finally,': [160], 'evidence': [163], 'synthesis': [168], 'directly': [173], 'impact': [174], 'virus': [175, 179, 197, 203], 'gene': [176], 'expression': [177], 'growth.': [180], 'Together,': [181], 'findings': [183], 'demonstrate': [184], 'host': [186], 'dynamically': [190], 'regulated': [191], 'upon': [192], 'herpes': [196], 'manner': [200], 'impacts': [202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082617936', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-17T16:03:52.878459', 'created_date': '2016-06-24'}