Publication Information

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'https://openalex.org/W2160119440', 'https://openalex.org/W2162671646', 'https://openalex.org/W2167029659', 'https://openalex.org/W2169064412', 'https://openalex.org/W2344075473', 'https://openalex.org/W2407224227', 'https://openalex.org/W2428478307', 'https://openalex.org/W4294216491'], 'related_works': ['https://openalex.org/W2472394872', 'https://openalex.org/W2400378532', 'https://openalex.org/W2328254289', 'https://openalex.org/W2076243961', 'https://openalex.org/W2054206927', 'https://openalex.org/W2053177676', 'https://openalex.org/W2015410009', 'https://openalex.org/W2007080076', 'https://openalex.org/W1997541978', 'https://openalex.org/W1968515315'], 'abstract_inverted_index': {'Prostaglandin': [0, 185], 'E2(PGE2)': [1, 186], 'production': [2, 181, 187, 366, 2331, 4043], 'involves': [3, 188], 'the': [4, 35, 47, 97, 101, 122, 170, 189, 220, 232, 282, 286, 307, 355, 381, 392, 402, 511, 758, 820, 924, 1205, 1249, 1368, 1426, 1439, 1455, 1482, 1520, 1535, 1592, 1651, 1663, 1874, 2006, 2018, 2025, 2073, 2078, 2084, 2092, 2178, 2318, 2351, 2360, 2368, 2381, 2392, 2395, 2399, 2402, 2410, 2423, 2466, 2546, 2555, 2594, 2645, 2723, 2737, 2831, 2855, 2913, 2918, 2929, 2974, 2980, 2987, 3023, 3067, 3100, 3103, 3113, 3164, 3176, 3186, 3216, 3220, 3253, 3277, 3308, 3327, 3339, 3365, 3378, 3403, 3411, 3418, 3424, 3431, 3434, 3443, 3446, 3450, 3455, 3480, 3514, 3521, 3531, 3534, 3541, 3570, 3590, 3593, 3607, 3676, 3701, 3712, 3727, 3756, 3800, 3810, 3836, 3842, 3908, 3936, 3941, 4018, 4027, 4064, 4068, 4093, 4113, 4170, 4176, 4208, 4217, 4237, 4247, 4274, 4321, 4324, 4343, 4348], 'activity': [5, 190, 2378, 3723], 'of': [6, 14, 85, 92, 103, 124, 129, 145, 159, 172, 191, 199, 270, 277, 288, 309, 314, 330, 344, 357, 380, 397, 413, 513, 519, 760, 770, 822, 928, 982, 1076, 1251, 1275, 1425, 1441, 1454, 1467, 1481, 1499, 1522, 1537, 1594, 1649, 1653, 1750, 1777, 1828, 1880, 2008, 2017, 2027, 2066, 2095, 2101, 2227, 2237, 2320, 2338, 2354, 2362, 2383, 2391, 2394, 2401, 2425, 2520, 2541, 2554, 2568, 2589, 2610, 2647, 2727, 2736, 2758, 2846, 2857, 2867, 2931, 2973, 3102, 3158, 3166, 3183, 3310, 3341, 3407, 3445, 3454, 3483, 3503, 3513, 3533, 3592, 3614, 3621, 3658, 3758, 3792, 3799, 3809, 3877, 3891, 3953, 3958, 3998, 4008, 4013, 4020, 4049, 4058, 4067, 4077, 4081, 4103, 4112, 4150, 4160, 4178, 4181, 4239, 4323, 4334, 4345], 'a': [7, 117, 127, 192, 302, 312, 494, 516, 935, 979, 1109, 1186, 1258, 1262, 1271, 1280, 1459, 1465, 1734, 1802, 1825, 1878, 2171, 2233, 2517, 2551, 2602, 2818, 2844, 2905, 3031, 3108, 3137, 3333, 3471, 3506, 3560, 3574, 3628, 3787, 3845, 3887, 4006, 4047, 4055, 4073, 4108, 4157, 4232, 4283, 4301, 4363], 'multistep': [8, 193], 'biosynthetic': [9, 194, 383, 1484], 'pathway.': [10, 195], 'The': [11, 90, 196, 275, 370, 498, 1104, 1347, 2463, 2959, 2999, 3223, 3314, 3548, 3650, 3796, 3951, 4011, 4079, 4139, 4148, 4313, 4354], 'terminal': [12, 197, 925], 'components': [13, 198, 1480], 'this': [15, 130, 200, 315, 1014, 1199, 2064, 3119], 'cascade,': [16, 201], 'two': [17, 202, 398, 823, 3187, 3379], 'PGE2': [18, 180, 203, 365, 1500, 2096, 2158, 2330, 2663, 3468, 4016, 4042], 'synthases': [19, 204], '(PGES),': [20, 205], 'have': [21, 206, 501, 1366, 1475, 2002, 2719, 2852], 'very': [22, 71, 207, 256, 812], 'recently': [23, 208, 1561], 'been': [24, 209, 970, 1430, 1476, 1562, 2003, 2720, 2849], 'identified': [25, 210], 'as': [26, 211, 1564, 1884, 2166, 2694, 2791, 3136, 3627, 3698, 3781, 4005, 4026, 4231, 4362], 'glutathione-dependent': [27, 212, 921], 'proteins.': [28, 213, 3313], 'cPGES': [29, 214, 941, 974, 1061, 1252, 1351, 2491, 3304, 3999, 4335], 'is': [30, 55, 100, 215, 240, 285, 544, 551, 638, 934, 975, 1108, 1191, 1352, 1434, 1576, 2063, 2091, 2333, 3896, 3910, 4044, 4105, 4221, 4356], 'cytoplasmic,': [31, 216], 'apparently': [32, 217], 'identical': [33, 218, 976, 3884], 'to': [34, 152, 219, 337, 553, 764, 930, 977, 1018, 1029, 1065, 1354, 1478, 1519, 1568, 1866, 1877, 2077, 2106, 2765, 2767, 2777, 2863, 2904, 2964, 3003, 3099, 3118, 3163, 3202, 3250, 3258, 3323, 3337, 3363, 3369, 3384, 3399, 3467, 3489, 3491, 3501, 3511, 3530, 3569, 3580, 3655, 3742, 3821, 3832, 3869, 3906, 3989, 4090, 4168, 4188, 4204, 4347], 'hsp90': [36, 221, 983], 'chaperone,': [37, 222], 'p23,': [38, 223, 978, 3016], 'and': [39, 57, 66, 87, 108, 139, 148, 174, 224, 242, 251, 272, 293, 324, 333, 359, 394, 401, 411, 415, 459, 492, 515, 550, 651, 772, 814, 922, 1183, 1198, 1261, 1356, 1379, 1486, 1493, 1527, 1530, 1572, 1598, 1659, 1661, 1665, 1823, 1843, 1888, 2029, 2168, 2332, 2341, 2358, 2370, 2415, 2440, 2449, 2469, 2504, 2531, 2545, 2593, 2642, 2674, 2731, 2760, 2787, 2813, 2833, 2860, 2871, 2908, 2933, 2984, 2993, 3007, 3017, 3049, 3065, 3105, 3112, 3123, 3142, 3196, 3236, 3248, 3252, 3269, 3303, 3326, 3343, 3354, 3371, 3410, 3420, 3433, 3465, 3546, 3553, 3582, 3618, 3685, 3715, 3745, 3768, 3866, 3893, 3929, 3969, 3972, 4000, 4022, 4041, 4084, 4117, 4180, 4193, 4266, 4291, 4336], 'associates': [40, 225], 'functionally': [41, 226], 'with': [42, 162, 227, 347, 1027, 1031, 1279, 1452, 1464, 2081, 2323, 2335, 2774, 2912, 2949, 2990, 3012, 3107, 3131, 3171, 3276, 3290, 3332, 3357, 3374, 3438, 3520, 3634, 3643, 3726, 3812, 3826, 4107, 4236, 4278, 4295], 'prostaglandin-endoperoxide': [43, 228, 775], 'H': [44, 229, 457, 469, 776], 'synthase-1': [45, 230, 458], '(PGHS-1),': [46, 231], 'constitutive': [48, 233, 1008], 'cyclooxygenase.': [49, 234], 'A': [50, 235, 811, 2573, 4034, 4215], 'second': [51, 236, 2832], 'synthase,': [52, 237], 'designated': [53, 238, 940, 2548, 3576], 'mPGES,': [54, 125, 239, 310, 1107], 'microsomal': [56, 241, 801, 1111], 'can': [58, 109, 243, 294, 1114, 1201, 1495, 2159], 'be': [59, 110, 244, 295, 1019, 1066, 1115, 1181, 1202, 1462, 2160, 2864], 'regulated.': [60, 245], 'Here': [61, 246], 'we': [62, 247, 2315], 'demonstrate': [63, 248], 'that': [64, 169, 249, 354, 404, 973, 984, 1113, 1350, 1357, 1370, 1453, 1469, 1579, 1586, 1736, 2061, 2068, 2086, 2317, 2420, 3957, 3961, 4299], 'mPGES': [65, 88, 147, 175, 250, 273, 332, 360, 1190, 1256, 1358, 2342, 2384, 2416, 2468, 2474, 3018, 3122, 3195, 3302, 3516, 3892, 3954, 3984, 4023, 4083, 4182, 4280], 'PGHS-2': [67, 86, 133, 149, 173, 252, 271, 318, 334, 358, 637, 761, 2175, 2238, 2340, 2377, 2414, 2532, 2557, 3124, 3197, 3270, 3572, 3595, 3918, 3945, 3959, 4021, 4039, 4085, 4179, 4220, 4260], 'are': [68, 253, 490, 510, 762, 920, 1517, 1531, 1748, 1873, 2024, 2346, 3851, 3920, 3948, 3964, 4002, 4024], 'expressed': [69, 254, 546, 639, 937, 1182, 3897, 4357], 'at': [70, 96, 255, 281, 2823, 3054, 3082, 3282, 3417, 3665, 3717, 3750, 3856, 3871, 3898, 3912, 3923, 3932, 3967, 3992, 4046, 4061, 4200, 4251, 4270, 4303], 'low': [72, 257], 'levels': [73, 84, 258, 269, 1250, 2353, 3798, 3855, 3900, 3919, 3947, 3963, 3986, 3997, 4249, 4262, 4333], 'in': [74, 182, 259, 367, 377, 385, 505, 547, 557, 640, 1010, 1021, 1025, 1069, 1185, 1195, 1253, 1418, 1446, 1534, 1588, 1591, 1646, 1870, 2005, 2022, 2072, 2104, 2157, 2176, 2326, 2329, 2350, 2380, 2398, 2417, 2422, 2710, 2817, 2901, 2917, 3030, 3144, 3179, 3219, 3245, 3386, 3391, 3423, 3442, 3494, 3700, 3708, 3733, 3838, 3848, 3940, 3960, 4029, 4072, 4172, 4212], 'untreated': [75, 260, 3350], 'human': [76, 261, 1557, 2074, 2467, 2473, 2529, 2556, 2619, 2630, 3301, 3484, 3571, 3594, 4122], 'orbital': [77, 183, 262, 368, 1731, 1871, 2089, 2216, 2321, 2418, 2708, 3351, 3816, 4173], 'fibroblasts.': [78, 184, 263, 369], 'Interleukin': [79, 264], '(IL)-1β': [80, 265], 'treatment': [81, 136, 266, 321, 1030, 1247, 2319, 3456], 'elicits': [82, 267, 3844], 'high': [83, 268, 3062, 4109], 'expression.': [89, 274, 2343, 4147], 'induction': [91, 123, 171, 276, 308, 356, 2236, 2337, 2385, 3890, 3952, 4057, 4080, 4177, 4314], 'both': [93, 146, 278, 331, 1595, 2339, 2618, 4082], 'enzymes': [94, 279, 1383, 1428, 3188], 'occurs': [95, 280], 'pretranslational': [98, 283], 'level,': [99, 284], 'consequence': [102, 287, 4007], 'enhanced': [104, 289], 'gene': [105, 290, 3159], 'promoter': [106, 291, 3504, 3517, 3616], 'activities,': [107, 292, 3505], 'blocked': [111, 296, 1203, 2161], 'by': [112, 176, 297, 361, 647, 1193, 1204, 1362, 2162, 2220, 2230, 2386, 2479, 2495, 2562, 2584, 2635, 2644, 2722, 2743, 2755, 2869, 2928, 2978, 2985, 3022, 3072, 3092, 3191, 3463, 3711, 3804, 4086, 4092, 4156, 4330], 'dexamethasone': [113, 298, 1207, 4096, 4104], '(10': [114, 299, 3173, 3271, 3359, 3690, 3828, 4097, 4196], 'nm).': [115, 300], 'SC58125,': [116, 301], 'PGHS-2-selective': [118, 303], 'inhibitor,': [119, 304], 'could': [120, 305], 'attenuate': [121, 306], 'suggesting': [126, 311, 2170], 'dependence': [128, 313], 'enzyme': [131, 316, 828, 933, 1179, 1260, 1283, 2397, 3312, 4146, 4152], 'on': [132, 317, 3074, 4015, 4038, 4121, 4144, 4358], 'activity.': [134, 319], 'IL-1β': [135, 177, 320, 362, 1032, 2221, 2324, 3132, 3172, 3358, 3409, 3689, 3827, 4009, 4014, 4060, 4087, 4195, 4240, 4346], 'activates': [137, 322], 'p38': [138, 323, 2369, 2580, 2673, 3342, 3767], 'ERK': [140, 325, 2371, 2599, 2675, 3344], 'mitogen-activated': [141, 326, 790, 2372], 'protein': [142, 327, 406, 478, 791, 1062, 1112, 2373, 2475, 3909, 3946, 3985], 'kinases.': [143, 328, 2375, 3380], 'Induction': [144, 329], 'was': [150, 335, 391, 1016, 1063, 2428, 2459, 2492, 2516, 2559, 2581, 2601, 2632, 2808, 2923, 2962, 2976, 3001, 3028, 3161, 3189, 3321, 3428, 3459, 3518, 3551, 3597, 3653, 3706, 3724, 3748, 4088, 4154, 4166, 4198, 4229, 4276, 4286, 4292, 4308, 4315], 'susceptible': [151, 336, 2076, 4089], 'either': [153, 338, 3688], 'chemical': [154, 339], 'inhibition': [155, 340, 4159], 'or': [156, 341, 1033, 1423, 2222, 2224, 2703, 3170, 3695, 3825], 'molecular': [157, 342, 395, 1664], 'interruption': [158, 343], 'these': [160, 345, 2102, 2858, 3311], 'pathways': [161, 346, 384], 'dominant': [163, 348, 778, 2172, 2574], 'negative': [164, 349, 779, 2575], 'constructs.': [165, 350], 'These': [166, 351, 1414, 1514, 2000, 2155, 2344, 2404, 2717, 3775], 'results': [167, 352, 2325, 2379, 4071], 'indicate': [168, 353], 'underlies': [178, 363], 'robust': [179, 364, 1875, 2235], 'past': [371], 'decade': [372], 'has': [373, 817, 969, 1559], 'witnessed': [374], 'dramatic': [375, 2093, 2327, 3846], 'advances': [376], 'our': [378], 'understanding': [379], 'prostanoid': [382, 1483], 'mammalian': [386], 'cells.': [387], 'Of': [388, 1863], 'particular': [389, 1281, 1490, 1864], 'importance': [390], 'discovery': [393], 'characterization': [396], 'cyclooxygenase': [399], 'isoforms': [400, 500, 829, 1378, 1444, 2621], 'realization': [403], 'each': [405, 1276, 3746], 'might': [407, 1445], 'possess': [408, 1801], 'distinct': [409, 1826], 'functions': [410], 'patterns': [412], 'expression': [414, 1009, 1015, 1440, 2400, 2577, 2596, 3757, 4019, 4040, 4153], 'regulation': [416], '(1.Smith': [417, 560], 'W.L.': [418, 440, 561, 583], 'Garavito': [419, 443, 562, 586], 'R.M.': [420, 444, 563, 587], 'DeWitt': [421, 441, 564, 584], 'D.L.': [422, 442, 565, 585, 678, 682], 'J.': [423, 566, 626, 661, 702, 719, 724, 865, 903, 952, 1045, 1088, 1162, 1230, 1294, 1331, 1398, 1548, 1613, 1680, 1700, 1720, 1766, 1789, 1811, 1834, 1855, 1909, 1930, 1947, 1990, 2127, 2147, 2198, 2257, 2278, 2298, 2796, 2888], 'Biol.': [424, 567, 662, 703, 725, 866, 904, 953, 1046, 1089, 1163, 1231, 1295, 1332, 1399, 1910, 2128, 2199, 2258, 2299], 'Chem.': [425, 568, 663, 704, 726, 867, 905, 954, 1047, 1090, 1164, 1232, 1296, 1333, 1400, 1911, 2129, 2200, 2259, 2300], '1996;': [426, 569, 1793, 1912, 2130, 2201, 2260], '271:': [427, 570, 1913, 2131, 2202, 2261], '33157-33160Abstract': [428, 571], 'Full': [429, 431, 533, 535, 572, 574, 667, 708, 730, 871, 873, 909, 911, 958, 960, 1051, 1053, 1094, 1096, 1168, 1170, 1236, 1238, 1300, 1302, 1337, 1339, 1404, 1406, 1915, 1917, 2051, 2133, 2135, 2204, 2206, 2263, 2265, 2304, 2306, 4131], 'Text': [430, 432, 534, 536, 573, 575, 668, 709, 731, 872, 874, 910, 912, 959, 961, 1052, 1054, 1095, 1097, 1169, 1171, 1237, 1239, 1301, 1303, 1338, 1340, 1405, 1407, 1916, 1918, 2052, 2134, 2136, 2205, 2207, 2264, 2266, 2305, 2307, 4132], 'PDF': [433, 537, 576, 669, 710, 732, 875, 913, 962, 1055, 1098, 1172, 1240, 1304, 1341, 1408, 1919, 2053, 2137, 2208, 2267, 2308, 4133], 'PubMed': [434, 451, 538, 577, 594, 610, 630, 670, 693, 711, 733, 750, 850, 876, 914, 963, 1056, 1099, 1135, 1173, 1241, 1305, 1342, 1409, 1620, 1639, 1707, 1725, 1773, 1796, 1818, 1860, 1920, 1935, 1952, 1977, 1997, 2054, 2138, 2152, 2209, 2268, 2283, 2309, 2658, 2802, 2895, 2944, 4134], 'Scopus': [435, 452, 539, 578, 595, 611, 631, 694, 751, 851, 877, 915, 964, 1057, 1100, 1136, 1174, 1242, 1306, 1343, 1410, 1640, 1726, 1797, 1819, 1921, 1978, 2055, 2139, 2210, 2269, 2310, 2659, 2803, 2945, 4135], '(1868)': [436, 579], 'Google': [437, 454, 541, 580, 597, 613, 633, 671, 696, 712, 734, 753, 853, 879, 917, 966, 1003, 1059, 1102, 1138, 1176, 1244, 1308, 1345, 1412, 1553, 1621, 1642, 1685, 1708, 1728, 1774, 1799, 1821, 1841, 1861, 1923, 1936, 1953, 1980, 1998, 2057, 2141, 2153, 2212, 2271, 2284, 2312, 2661, 2805, 2896, 2947, 4137], 'Scholar,': [438, 581, 598, 614, 672, 697, 713, 735, 854, 880, 1139, 1622, 1686, 1709, 1924, 1937, 1954, 1981, 2272, 2285], '2.Smith': [439, 582], 'Annu.': [445, 588], 'Rev.': [446, 589], 'Biochem.': [447, 590, 603, 2940], '2000;': [448, 591, 868, 906, 955, 1000, 1048, 1091, 1165, 1233, 1297, 1334, 1722], '69:': [449, 592, 1816], '145-182Crossref': [450, 593], '(2521)': [453, 596], 'Scholar).': [455, 542, 634, 754, 918, 967, 1004, 1060, 1103, 1177, 1245, 1346, 1413, 1513, 1554, 1643, 1729, 1862, 1999, 2058, 2154, 2213, 2313, 2662, 2806, 2897, 4138], 'Prostaglandin-endoperoxide': [456], '-2': [460], '(EC': [461, 830], '1.14.99.1,': [462], 'PGHS)': [463], '1The': [464], 'abbreviations': [465], 'used': [466, 3322, 3539], 'are:': [467], 'PGHSprostaglandin-endoperoxide': [468], 'synthaseDNdominant': [470], 'negativeDRB5,6-dichlorobenzimidazoleERKextracellular': [471], 'signal-regulated': [472, 782], 'kinaseFBSfetal': [473], 'bovine': [474, 785, 2781], 'serumGAPDHglyceraldehyde-3-phosphate': [475], 'dehydrogenaseILinterleukinMAP': [476], 'kinasemitogen-activated': [477], 'kinasePBSphosphate-buffered': [479], 'salinePGE2prostaglandin': [480], 'E2PGESprostaglandin': [481], 'synthasecPGEScytoplasmic': [482], 'PGESmPGESmicrosomal': [483], 'PGESTAOthyroid-associated': [484], 'ophthalmopathyTNFtumor': [485], 'necrosis': [486, 806], 'factorTGFtransforming': [487], 'growth': [488, 649, 809, 1886, 3145], 'factor': [489, 807, 810], 'membrane-associated': [491], 'contain': [493], 'heme': [495], 'prosthetic': [496], 'group.': [497], 'PGHS': [499, 1282, 1377, 1443, 2620], 'received': [502, 3687, 3786], 'substantial': [503, 1007, 4158], 'attention,': [504], 'large': [506, 517, 1497], 'part': [507], 'because': [508], 'they': [509], 'targets': [512], 'aspirin': [514], 'series': [518], 'nonsteroidal': [520], 'anti-inflammatory': [521], 'compounds': [522, 3414], '(3.Smith': [523], 'T.J.': [524, 1504, 1542, 1601, 1628, 1674, 1688, 1719, 1754, 1788, 1806, 1833, 1847, 1908, 1928, 1939, 1956, 1989, 2036, 2126, 2145, 2197, 2256, 2276, 2297, 2795, 2876, 4126], 'Rheum.': [525], 'Dis.': [526], 'Clin.': [527, 1506, 1614, 1701, 1767, 1790, 1812, 1835, 1991, 2797, 2889], 'North': [528], 'Am.': [529, 1547, 1679, 1854, 1929, 1946, 2146, 2277], '1998;': [530, 1636, 2301], '24:': [531], '501-523Abstract': [532], '(35)': [540], 'PGHS-1': [543, 1355, 2530, 3268, 4001, 4337, 4366], 'constitutively': [545, 936], 'most': [548, 641], 'tissues': [549, 642, 1494, 2071, 2709], 'thought': [552, 763], 'generate': [554, 1496, 3324], 'prostaglandins': [555], 'involved': [556], 'housekeeping': [558], 'activities': [559, 759, 2718], '4.Yokoyama': [599], 'C.': [600], 'Tanabe': [601, 1392], 'T.': [602, 721, 723, 737, 856, 886, 894, 943, 1036, 1079, 1145, 1153, 1213, 1221, 1285, 1314, 1322, 1389, 1393, 2044], 'Biophys.': [604], 'Res.': [605], 'Commun.': [606], '1989;': [607, 1815], '165:': [608], '888-894Crossref': [609], '(301)': [612], '5.Funk': [615], 'C.D.': [616], 'Funk': [617], 'L.B.': [618], 'Kennedy': [619], 'M.E.': [620], 'Pong': [621], 'A.S.': [622], 'Fitzgerald': [623], 'G.A.': [624], 'FASEB': [625], '1991;': [627, 664, 690], '5:': [628], '2304-2312Crossref': [629], '(541)': [632], 'In': [635, 2214, 3294, 3995], 'contrast,': [636, 3996], 'only': [643, 1560], 'following': [644, 2099, 3080, 3215, 4342], 'cell': [645, 1023, 1187, 1380, 3347], 'activation': [646, 3340], 'cytokines,': [648, 1885], 'factors,': [650, 1887], 'mitogens': [652], "(6.O'Banion": [653], 'M.K.': [654], 'Sadowski': [655], 'H.B.': [656], 'Winn': [657, 1895, 2113, 2184, 2243], 'V.': [658], 'Young': [659, 1905, 2123, 2194, 2253], 'D.A.': [660, 699, 1624, 1906, 2124, 2195, 2254], '266:': [665], '23261-23267Abstract': [666], '7.Xie': [673], 'W.': [674, 1713], 'Chipman': [675], 'J.G.': [676], 'Robertson': [677], 'Erikson': [679], 'R.L.': [680], 'Simmons': [681], 'Proc.': [683, 740, 840, 1125, 1629, 1967], 'Natl.': [684, 741, 841, 1126, 1630, 1968], 'Acad.': [685, 742, 842, 1127, 1631, 1969], 'Sci.': [686, 743, 843, 1128, 1632, 1970], 'U.': [687, 744, 844, 1129, 1633, 1971], 'S.': [688, 717, 745, 835, 845, 900, 1120, 1130, 1159, 1227, 1328, 1634, 1972], 'A.': [689, 715, 746, 846, 898, 1131, 1157, 1225, 1326, 1635, 1782, 1786, 1941, 1973], '88:': [691], '2692-2696Crossref': [692], '(1715)': [695], '8.Kujubu': [698], 'Herschman': [700], 'H.R.': [701], '1992;': [705, 747, 1949], '267:': [706], '7991-7994Abstract': [707], '9.Ristimäki': [714], 'Garfinkel': [716], 'Wessendorf': [718], 'Maciag': [720], 'Hla': [722], '1994;': [727, 1974, 2655], '269:': [728], '11769-11775Abstract': [729], '10.Hla': [736], 'Neilson': [738], 'K.': [739, 1391], '89:': [748], '7384-7388Crossref': [749], '(1497)': [752], 'Prostanoids': [755], 'generated': [756, 1361, 2754, 3021], 'through': [757, 2225, 2348, 2966], 'represent': [765, 1582], 'those': [766, 3355], 'produced': [767], 'under': [768, 2996, 3061, 3883, 3901, 4224, 4288], 'circumstances': [769], 'inflammation': [771, 1872], 'tissue': [773, 1525, 1570, 1657, 2019, 2691], 'disruption.': [774], 'synthase': [777, 798, 827], '5,6-dichlorobenzimidazole': [780, 2437], 'extracellular': [781], 'kinase': [783, 792], 'fetal': [784, 2780], 'serum': [786, 2782], 'glyceraldehyde-3-phosphate': [787], 'dehydrogenase': [788], 'interleukin': [789], 'phosphate-buffered': [793, 3439], 'saline': [794, 3440], 'prostaglandin': [795, 797, 824], 'E2': [796, 825], 'cytoplasmic': [799], 'PGES': [800, 802, 1277, 1456], 'thyroid-associated': [803, 2009], 'ophthalmopathy': [804, 2010], 'tumor': [805], 'transforming': [808], 'recent': [813, 1268], 'significant': [815], 'advance': [816], 'resulted': [818], 'from': [819, 1489, 1740, 1743, 2443, 2453, 2461, 2508, 2536, 2604, 2624, 2668, 2678, 2690, 2700, 2705, 2836, 2925, 2955, 3087, 3211, 3349, 3430, 3555, 3589, 3880], 'identification': [821], '(PGE2)': [826], '5.3.99.3)': [831], '(11.Jakobsson': [832, 1117], 'P.-J.': [833, 1118], 'Thorén': [834, 1119], 'Morgenstern': [836, 1121], 'R.': [837, 1122, 2637], 'Samuelsson': [838, 1123], 'B.': [839, 1124], '1999;': [847, 1132, 1509, 1932, 2149, 2280], '96:': [848, 1133], '7220-7225Crossref': [849, 1134], '(905)': [852, 1137], '12.Tanioka': [855], 'Nakatani': [857, 889, 944, 1037, 1080, 1148, 1216, 1286, 1317], 'Y.': [858, 890, 945, 1038, 1081, 1149, 1217, 1287, 1318, 1395, 1900, 2118, 2189, 2248, 2291], 'Semmyo': [859, 887, 946, 1039, 1082, 1146, 1214, 1288, 1315], 'N.': [860, 888, 947, 1040, 1083, 1147, 1215, 1289, 1316, 1385, 2938], 'Murakami': [861, 948, 1041, 1084, 1290, 1386], 'M.': [862, 882, 896, 949, 1042, 1085, 1141, 1155, 1209, 1223, 1291, 1310, 1324, 1387, 2565], 'Kudo': [863, 901, 950, 1043, 1086, 1160, 1228, 1292, 1329, 1396, 2498], 'I.': [864, 902, 951, 1044, 1087, 1161, 1229, 1293, 1330, 1397, 1966, 1987, 2497], '275:': [869, 907, 956, 1049, 1092, 1166, 1234, 1298, 1335], '32775-32782Abstract': [870, 957, 1050, 1093, 1299], '(639)': [878, 965, 1058, 1101, 1307], '13.Murakami': [881, 1140], 'Naraba': [883, 1142, 1210, 1311], 'H.': [884, 1143, 1211, 1312, 1851], 'Tanioka': [885, 1144, 1212, 1313, 1388], 'Kojima': [891, 1150, 1218, 1319], 'F.': [892, 1151, 1219, 1320], 'Ikeda': [893, 1152, 1220, 1321], 'Fueki': [895, 1154, 1222, 1323], 'Ueno': [897, 1156, 1224, 1325], 'Oh-ishi': [899, 1158, 1226, 1327], '32783-32792Abstract': [908, 1167, 1235, 1336], '(865)': [916, 1175, 1243, 1344], 'Both': [919], 'catalyze': [923], 'conversion': [926], 'reaction': [927, 2034], 'PGH2': [929, 1360], 'PGE2.': [931, 2426], 'One': [932], 'cytosolic': [938], 'protein,': [939], '(12.Tanioka': [942, 1035, 1078, 1284], 'Evidence': [968], 'advanced': [971], 'indicating': [972, 2388], 'putative': [980, 3515], 'chaperone': [981], 'stabilizes': [985], 'steroid': [986, 4140], 'hormone': [987], 'receptor-hsp90': [988], 'complexes': [989], '(14.Freeman': [990], 'B.C.': [991], 'Felts': [992], 'S.J.': [993], 'Toft': [994, 2523], 'D.O.': [995], 'Yamamoto': [996], 'K.R.': [997], 'Genes': [998], 'Dev.': [999], '14:': [1001], '422-434PubMed': [1002], 'It': [1005, 1575], 'exhibits': [1006], 'many': [1011], 'tissues.': [1012], 'Moreover,': [1013], 'reported': [1017], 'invariant': [1020], 'several': [1022], 'lines': [1024], 'vitro': [1026], 'regard': [1028, 3336, 3500, 3568, 3905], 'TNF-α': [1034], 'found': [1064, 2861], 'induced': [1067, 1192, 4230], 'modestly': [1068, 3965], 'rat': [1070, 1196], 'brain': [1071], '48': [1072, 3055, 3833, 3872, 3993, 4271, 4319], 'h': [1073, 3135, 3281, 3406, 3664, 3694, 3971], 'after': [1074, 2843], 'injection': [1075], 'lipopolysaccharide': [1077, 1194], 'other': [1105, 1744, 3295, 3412], 'isoform,': [1106], '16-kDa': [1110], 'regulated': [1116, 1184, 1259], 'This': [1178], 'may': [1180], 'type-specific': [1188, 1381], 'manner.': [1189], 'macrophages,': [1197], 'up-regulation': [1200, 2094, 2179], 'glucocorticoid,': [1206, 4095], '(13.Murakami': [1208], 'Neither': [1246, 3895], 'altered': [1248, 4004], 'macrophages.': [1254], 'Thus': [1255], 'represents': [1257, 1779], 'potentially': [1263, 1566, 3759], 'important': [1264, 1567], 'drug': [1265], 'target.': [1266], 'Very': [1267], 'studies': [1269, 1348, 1365, 3478], 'imply': [1270], 'preferential,': [1272], 'functional': [1273, 1471], 'association': [1274], 'isoform': [1278], 'Scholar,13.Murakami': [1309], 'demonstrated': [1349], 'linked': [1353], 'utilizes': [1359], 'PGHS-2.': [1363, 3894], 'Further': [1364], 'extended': [1367], 'notion': [1369], 'functional,': [1371], 'stimuli-dependent': [1372], 'linkage': [1373], 'exists': [1374], 'between': [1375, 2413, 2830, 4175], 'specific': [1376, 2163], 'downstream': [1382], '(15.Ueno': [1384], 'Fujimori': [1390], 'Urade': [1394], '2001;': [1401], '276:': [1402], '34918-34927Abstract': [1403], '(179)': [1411], 'observations': [1415], 'were': [1416, 2442, 2451, 2476, 2506, 2534, 2622, 2666, 2676, 2688, 2704, 2740, 2753, 2762, 2772, 2789, 2815, 2828, 2841, 2899, 2909, 3010, 3059, 3070, 3090, 3095, 3116, 3129, 3140, 3200, 3209, 3242, 3256, 3274, 3288, 3305, 3330, 3361, 3367, 3382, 3397, 3415, 3436, 3487, 3601, 3632, 3682, 3740, 3770, 3776, 3802, 3819, 4186, 4250, 4267, 4339], 'made': [1417], 'transfected': [1419, 3603, 3778], 'cells': [1420, 1516, 1585, 2103, 2874, 3661, 3780], 'where': [1421], 'one': [1422, 1776], 'more': [1424], 'relevant': [1427, 3760, 3813], 'had': [1429, 2848, 4141, 4263], 'over-expressed.': [1431], 'Importantly,': [1432], 'nothing': [1433, 3696], 'known': [1435], 'currently': [1436], 'about': [1437], 'whether': [1438], 'endogenous': [1442], 'some': [1447, 2389, 3686], 'way': [1448], 'exhibit': [1449, 1733, 2232], 'physiological': [1450], 'coordination': [1451], 'enzymes.': [1457], 'Such': [1458], 'coupling': [1460], 'would': [1461], 'consistent': [1463], 'model': [1466], 'PGE2production': [1468], 'exhibited': [1470], 'cellular': [1472, 1669, 3878], 'compartmentalization.': [1473], 'Fibroblasts': [1474, 1644, 2898, 3381], 'shown': [1477, 4211], 'express': [1479], 'pathways,': [1485, 2366], 'cultures': [1487, 2687, 2859, 3128, 3353, 3486, 3681, 3785, 4185], 'derived': [1488, 1742], 'anatomic': [1491, 1745], 'regions': [1492], 'amounts': [1498], 'when': [1501, 2218, 4306, 4326], 'provoked': [1502, 2219], '(16.Smith': [1503], 'Exp.': [1505], 'Endocrinol.': [1507, 1615, 1702, 1768, 1791, 1813, 1836, 1992, 2890], 'Diabetes.': [1508], '107': [1510], '(Suppl.):': [1511], 'S160-S163Google': [1512], 'sentinel': [1515], 'critical': [1518], 'orchestration': [1521], 'inflammatory': [1523, 2033], 'responses,': [1524], 'remodeling,': [1526], 'wound': [1528], 'healing': [1529], 'key': [1532], 'participants': [1533], 'evolution': [1536], 'fibrosis': [1538], '(17.Smith': [1539, 1671], 'R.S.': [1540, 1672, 1808], 'Smith': [1541, 1627, 1673, 1718, 1787, 1832, 1907, 1927, 1988, 2125, 2144, 2196, 2255, 2275, 2296], 'Blieden': [1543, 1675], 'T.M.': [1544, 1676], 'Phipps': [1545, 1611, 1677, 1698, 1764, 2294, 2639, 2886], 'R.P.': [1546, 1612, 1678, 1699, 1765, 2295, 2887], 'Pathol.': [1549, 1681], '1997;': [1550, 1682], '151:': [1551, 1683], '317-322PubMed': [1552, 1684], 'Diversity': [1555], 'among': [1556], 'fibroblasts': [1558, 1732, 1741, 2001, 2090, 2217, 2322, 2419, 2761, 3605, 3881, 4174], 'appreciated': [1563], 'being': [1565, 3641], 'normal': [1569, 1596, 2706], 'function': [1571, 1597, 1645], 'disease': [1573, 1881], 'manifestation.': [1574], 'now': [1577], 'clear': [1578], 'fibroblast': [1580, 2686, 2738, 3213, 3352, 3817, 4123], 'subsets': [1581, 1752], 'highly': [1583], 'specialized': [1584], 'participate': [1587], 'reactive': [1589], 'processes': [1590], 'context': [1593], 'pathology': [1599], '(18.Smith': [1600, 1753, 2875], 'Sempowski': [1602, 1689, 1755, 2877], 'G.D.': [1603, 1690, 1756, 2878], 'Wang': [1604, 1691, 1757, 1957, 2288, 2879], 'H.-S.': [1605, 1692, 1758, 1892, 1958, 1983, 2110, 2181, 2240, 2289, 2880], 'Del': [1606, 1693, 1759, 2881], 'Vecchio': [1607, 1694, 1760, 2882], 'P.J.': [1608, 1695, 1761, 1945, 2883], 'Lippe': [1609, 1696, 1762, 2884], 'S.D.': [1610, 1697, 1763, 2885], 'Metab.': [1616, 1703, 1769, 1792, 1814, 1837, 1993, 2891], '1995;': [1617, 1704, 1770, 1838, 1994, 2892], '80:': [1618, 1705, 1771, 1839, 1995, 2893], '2620-2625Crossref': [1619, 1706, 1772, 2894], '19.Young': [1623], 'Evans': [1625, 1901, 2119, 2190, 2249], 'C.H.': [1626, 1902, 2120, 2191, 2250], '95:': [1637], '8904-8909Crossref': [1638], '(58)': [1641], 'various': [1647, 4201], 'aspects': [1648], 'immunity,': [1650], 'recruitment': [1652], 'bone': [1654], 'marrow-derived': [1655], 'cells,': [1656], 'repair,': [1658], 'remodeling': [1660, 2020, 2079], 'provide': [1662, 2407], 'structural': [1666], 'infrastructure': [1667], 'supporting': [1668], 'cross-talk': [1670], '18.Smith': [1687], '20.Sciaky': [1710], 'D.': [1711, 1784, 1904, 2122, 2193, 2252], 'Brazer': [1712], 'Center': [1714], 'D.M.': [1715], 'Cruikshank': [1716], 'W.W.': [1717], 'Immunol.': [1721, 2654], '164:': [1723], '3806-3814Crossref': [1724], '(99)': [1727], 'Human': [1730, 3522], 'phenotype': [1735], 'sets': [1737], 'them': [1738, 2862, 2995], 'apart': [1739, 2088], 'regions.': [1746], 'They': [1747, 2771], 'composed': [1749], 'discrete': [1751], 'Scholar),': [1775], 'which': [1778, 2778, 3850], 'pre-adipocytes': [1780], '(21.Sorisky': [1781], 'Pardasani': [1783], 'Gagnon': [1785], '81:': [1794], '3428-3431Crossref': [1795], '(151)': [1798], 'Scholar);': [1800, 1822], 'characteristic': [1803], 'morphology': [1804], '(22.Smith': [1805], 'Bahn': [1807, 2746], 'Gorman': [1809], 'C.A.': [1810], '1019-1023Crossref': [1817], '(98)': [1820], 'display': [1824], 'pattern': [1827], 'gangliosides': [1829], '(23.Berenson': [1830], 'C.S.': [1831], '2668-2674PubMed': [1840], 'Scholar)': [1842, 2948], 'surface': [1844], 'receptors': [1845], '(24.Smith': [1846], 'Kottke': [1848], 'R.J.': [1849], 'Lum': [1850], 'Andersen': [1852], 'T.T.': [1853], 'Physiol.': [1856, 1931, 1948, 2148, 2279], '1993;': [1857], '265:': [1858], 'C138-C142Crossref': [1859], 'relevance': [1865], 'their': [1867, 2355, 3203, 3990], 'proposed': [1868], 'participation': [1869], 'responses': [1876, 2345], 'variety': [1879], 'mediators': [1882], 'such': [1883, 2165], 'bioactive': [1889], 'lipids': [1890], '(25.Wang': [1891, 2109, 2180, 2239], 'Cao': [1893, 2111, 2182, 2241], 'H.J.': [1894, 1926, 2112, 2143, 2183, 2242, 2274, 2287], 'V.D.': [1896, 2114, 2185, 2244], 'Rezanka': [1897, 2115, 2186, 2245], 'L.J.': [1898, 2116, 2187, 2246], 'Frobert': [1899, 2117, 2188, 2247], 'Sciaky': [1903, 2121, 2192, 2251], '22718-22728Abstract': [1914, 2132, 2203, 2262], '(93)': [1922, 2140, 2211, 2270], '26.Cao': [1925, 2273], '277:': [1933, 2150, 2281], 'C1075-C1085Crossref': [1934, 2151, 2282], '27.Smith': [1938], 'Ahmed': [1940], 'Hogg': [1942, 1959], 'M.G.': [1943, 1960], 'Higgins': [1944], '263:': [1950], 'C24-C29Crossref': [1951], '28.Smith': [1955], 'Henrikson': [1961], 'R.C.': [1962, 2046], 'Keese': [1963, 1984], 'C.R.': [1964, 1985], 'Giaever': [1965, 1986], '91:': [1975, 2049], '5094-5098Crossref': [1976], '(64)': [1979], '29.Wang': [1982], '3553-3560Crossref': [1996], 'implicated': [2004], 'pathogenesis': [2007], '(TAO),': [2011], 'an': [2012, 2030, 2950, 3156, 3734, 3807, 3976, 4279, 4297], 'autoimmune': [2013], 'process.': [2014], 'Two': [2015, 3536], 'hallmarks': [2016], 'observed': [2021, 2098], 'TAO': [2023, 2702], 'accumulation': [2026], 'hyaluronan': [2028], 'often': [2031], 'intense': [2032], '(30.Hufnagel': [2035], 'Hickey': [2037], 'W.F.': [2038], 'Cobbs': [2039], 'W.H.': [2040], 'Jakobiec': [2041], 'F.A.': [2042], 'Iwamoto': [2043], 'Eagle': [2045], 'Ophthalmology.': [2047], '1984;': [2048], '1411-1419Abstract': [2050], '(184)': [2056], 'We': [2059, 2851], 'hypothesize': [2060], 'it': [2062, 4307, 4327], 'set': [2065, 2087], 'attributes': [2067], 'renders': [2069], 'connective': [2070], 'orbit': [2075], 'associated': [2080, 2334, 4106], 'TAO.': [2082], 'Among': [2083], 'characteristics': [2085], 'synthesis': [2097], 'exposure': [2100, 3081], 'culture': [2105, 2769, 3656, 4226, 4349], 'proinflammatory': [2107], 'cytokines': [2108], 'Scholar,26.Cao': [2142], 'increases': [2156, 2328], 'inhibitors': [2164], 'SC58125': [2167, 2427], 'NS-398,': [2169], 'role': [2173], 'for': [2174, 2579, 2598, 2714, 3133, 3147, 3175, 3185, 3279, 3307, 3402, 3449, 3540, 3637, 3646, 3662, 3692, 3766, 3830, 3863, 4318], 'mediating': [2177], 'fact,': [2215], 'leukoregulin': [2223], 'engagement': [2226], 'surface-displayed': [2228], 'CD40': [2229], 'CD154,': [2231], 'particularly': [2234], '31.Cao': [2286], 'Zhang': [2290], 'Lin': [2292], 'H.-Y.': [2293], '273:': [2302], '29615-29625Abstract': [2303], '(183)': [2311], 'Here,': [2314], 'report': [2316], 'coordinate': [2336], 'mediated': [2347], 'elevations': [2349], 'steady-state': [2352], 'respective': [2356, 3204, 3447], 'mRNAs': [2357, 3184], 'involve': [2359], 'use': [2361], 'overlapping': [2363], 'intracellular': [2364], 'signaling': [2365, 3761], 'including': [2367], '(MAP)': [2374], 'Inhibiting': [2376], 'blockade': [2382, 4091, 4149], 'IL-1β,': [2387, 2446, 4296], 'involvement': [2390], 'products': [2393], 'former': [2396, 4355], 'latter.': [2403], 'latest': [2405], 'findings': [2406], 'insights': [2408], 'into': [2409, 3559, 3604, 3772, 3779], 'complex': [2411], 'interactions': [2412], 'culminate': [2421], 'generation': [2424], 'obtained': [2429, 2460, 2507, 2667, 2693], 'form': [2430], 'Searle': [2431], '(Skokie,': [2432], 'IL).': [2433], 'Dexamethasone': [2434], '(1,4': [2435], 'pregnadien-9-fluoro-16α-methyl-11β,17α,21-triol-3,20-dione),': [2436], '(DRB),': [2438], 'arachidonate,': [2439], 'cycloheximide': [2441], 'Sigma.': [2444], 'IL-1α,': [2445], 'IL-4,': [2447], 'TNF-α,': [2448], 'TGF-β': [2450], 'purchased': [2452, 2623, 2677, 2954], 'BIOSOURCE': [2454], '(Camarillo,': [2455], 'CA).': [2456, 2512, 2684], 'Interferon': [2457], 'γ': [2458], 'Invitrogen.': [2462], 'cDNA': [2464, 2515, 3019, 3110, 4281], 'encoding': [2465, 4219], 'antibodies': [2470, 2615, 3265, 3298, 3376], 'directed': [2471, 2616, 3266, 3299], 'against': [2472, 2490, 2617, 2672, 3267, 3300, 3377], 'kindly': [2477, 2493, 2633, 2741], 'provided': [2478, 2494, 2583, 2742, 3710], 'Dr.': [2480, 2521, 2537, 2563, 2585, 2605, 2636, 2744], 'Per-Johan': [2481], 'Jakobsson': [2482], '(Karolinska': [2483], 'Institute,': [2484], 'Stockholm,': [2485], 'Sweden).': [2486], 'An': [2487], 'affinity-purified': [2488], 'antibody': [2489], 'Prof.': [2496], '(Showa': [2499], 'University,': [2500], 'Tokyo,': [2501], 'Japan).': [2502], 'PD98059': [2503], 'SB203580': [2505], 'Calbiochem': [2509], '(La': [2510], 'Jolla,': [2511], 'p23': [2513], '(cPGES)': [2514], 'kind': [2518], 'gift': [2519, 2603], 'David': [2522], '(Mayo': [2524, 2747], 'Clinic,': [2525, 2748], 'Rochester,': [2526, 2542, 2543, 2749, 3078], 'MN);': [2527], 'full-length': [2528], 'cDNAs': [2533], 'gifts': [2535], 'Kerry': [2538], "O'Banion": [2539], '(University': [2540, 2567, 2588], 'NY),': [2544], 'plasmid': [2547, 3575], '−1800pGL2,': [2549, 3577], 'containing': [2550, 3033, 3393, 3496, 3578, 3672], '1.8-kb': [2552], 'fragment': [2553, 3508, 3550], 'promoter,': [2558, 3573, 3596], 'generously': [2560, 2582], 'supplied': [2561, 2634], 'Stephen': [2564], 'Prescott': [2566], 'Utah,': [2569], 'Salt': [2570], 'Lake': [2571], 'City).': [2572], '(DN)': [2576], 'vector': [2578, 2597, 3557, 3563, 3623, 3794], 'Roger': [2586], 'Davis': [2587], 'Massachusetts,': [2590], 'Worcester,': [2591], 'MA),': [2592], 'DN': [2595, 3764], '1': [2600, 3840, 4031, 4050], 'Melanie': [2606], 'Cobb': [2607], '(Southwestern': [2608], 'School': [2609], 'Medicine,': [2611], 'Dallas,': [2612], 'TX).': [2613, 2958], 'Monoclonal': [2614], 'Cayman': [2625], '(Ann': [2626], 'Arbor,': [2627], 'MI).': [2628], 'Recombinant': [2629], 'CD154': [2631], 'P.': [2638, 2936], '(Rochester,': [2640], 'NY)': [2641, 3079], 'prepared': [2643], 'method': [2646, 2930], 'Kehry': [2648], '(32.Kehry': [2649], 'M.R.': [2650], 'Castle': [2651], 'B.E.': [2652], 'Semin.': [2653], '6:': [2656], '287-294Crossref': [2657], '(79)': [2660], 'radioimmunoassay': [2664, 3469], 'kits': [2665], 'Amersham': [2669], 'Biosciences.': [2670], 'Antibodies': [2671], 'Santa': [2679], 'Cruz': [2680], 'Biotechnology': [2681], '(Santa': [2682], 'Cruz,': [2683], 'Orbital': [2685], 'initiated': [2689], 'explants': [2692], 'surgical': [2695], 'waste': [2696], 'during': [2697], 'decompression': [2698], 'surgery': [2699, 2713], 'severe': [2701], 'appearing': [2707], 'patients': [2711], 'undergoing': [2712], 'non-inflammatory': [2715], 'conditions.': [2716, 3903], 'approved': [2721], 'Institutional': [2724], 'Review': [2725], 'Boards': [2726], 'Albany': [2728], 'Medical': [2729, 2733], 'College': [2730], 'Harbor-UCLA': [2732], 'Center.': [2734], 'Some': [2735], 'strains': [2739, 2827], 'Rebecca': [2745], 'MN).': [2750], 'Tissue': [2751], 'fragments': [2752], 'mechanical': [2756], 'disruption': [2757], 'explants,': [2759], 'then': [2763, 2910, 3066, 3096, 3372, 3683, 3867, 4194], 'allowed': [2764, 3488], 'adhere': [2766], 'plastic': [2768, 3388], 'plates.': [2770], 'covered': [2773, 3437], "Eagle's": [2775, 3670], 'medium': [2776, 3146, 3165, 3392, 3401, 3495, 3657, 3671, 3823, 4189, 4350], '10%': [2779, 3394, 3497, 3673], '(FBS),': [2783], 'glutamine': [2784], '(435': [2785], 'μg/ml),': [2786, 3155], 'penicillin/streptomycin': [2788], 'added': [2790, 3162, 3416, 3654, 4199], 'described': [2792, 3782], 'previously': [2793], '(33.Smith': [2794], 'Invest.': [2798], '1987;': [2799, 2941], '79:': [2800], '1493-1497Crossref': [2801], '(33)': [2804, 4136], 'Medium': [2807, 3427], 'changed': [2809], 'every': [2810], '3–4': [2811], 'days,': [2812], 'monolayers': [2814, 2927, 3214, 3435, 3818], 'maintained': [2816], '5%': [2819], 'CO2,': [2820], 'humidified': [2821], 'incubator': [2822], '37': [2824, 3666], '°C.': [2825, 3084, 3667], 'Culture': [2826], 'utilized': [2829, 3306], 'twelfth': [2834], 'passage': [2835], 'initiation.': [2837], 'All': [2838], 'experimental': [2839], 'manipulations': [2840], 'conducted': [2842, 3029], 'state': [2845, 2907], 'confluence': [2847, 3385, 3493], 'reached.': [2850], 'already': [2853], 'established': [2854, 2977], 'purity': [2856], 'essentially': [2865], 'free': [2866], 'contamination': [2868], 'endothelial': [2870], 'smooth': [2872], 'muscle': [2873], 'cultivated': [2900], '100-mm-diameter': [2902], 'plates': [2903, 3168, 3390], 'confluent': [2906, 3660], 'treated': [2911, 3130, 3356, 3882], 'test': [2914, 3413], 'agents': [2915, 3448], 'specified': [2916], 'figure': [2919, 3221, 3425, 3702], 'legends.': [2920, 3222, 3426, 3703], 'Cellular': [2921, 3207, 3704], 'RNA': [2922, 2951, 2975, 3000], 'extracted': [2924], 'rinsed': [2926, 3212], 'Chomczynski': [2932], 'Sacchi': [2934, 2937], '(34.Chomczynski': [2935], 'Anal.': [2939], '162:': [2942], '156-159Crossref': [2943], '(64628)': [2946], 'isolating': [2952], 'system': [2953, 3320, 3610], 'Biotecx': [2956], '(Houston,': [2957], 'nucleic': [2960], 'acid': [2961], 'subjected': [2963, 3249, 3362, 3466], 'electrophoresis': [2965], 'denaturing': [2967], '1%': [2968, 3047], 'agarose,': [2969], 'formaldehyde': [2970], 'gels.': [2971], 'Integrity': [2972], 'determining': [2979], '260/280': [2981], 'spectroscopic': [2982], 'ratios': [2983], 'staining': [2986], 'electrophoresed': [2988], 'samples': [2989, 3009], 'ethidium': [2991], 'bromide': [2992], 'inspecting': [2994], 'UV': [2997], 'light.': [2998], 'transferred': [3002, 3257, 3368], 'Zeta-probe': [3004], 'membrane': [3005, 3261, 3370, 4275], '(Bio-Rad),': [3006], 'immobilized': [3008], 'hybridized': [3011], '[32P]dCTP-labeled': [3013], 'PGHS-1,': [3014], 'PGHS-2,': [3015, 3907, 3983], 'probes': [3020], 'random': [3024], 'primer': [3025], 'method.': [3026], 'Hybridization': [3027], 'solution': [3032], '5×': [3034, 3038], 'SSC,': [3035], '50%': [3036], 'formamide,': [3037], "Denhardt's": [3039], 'solution,': [3040], '50': [3041, 3231], 'mm': [3042, 3232], 'phosphate': [3043], 'buffer': [3044, 3226, 3247, 3709], '(pH': [3045, 3234], '6.5),': [3046], 'SDS,': [3048], '0.25': [3050], 'mg/ml': [3051], 'salmon': [3052], 'sperm': [3053], '°C': [3056, 3719], 'overnight.': [3057, 3679], 'Membranes': [3058, 3094], 'washed': [3060, 3141], 'stringency': [3063], 'conditions,': [3064], 'RNA/DNA': [3068], 'hybrids': [3069, 3089], 'visualized': [3071], 'autoradiography': [3073], 'X-Omat': [3075], 'film': [3076], '(Kodak,': [3077], '−70': [3083], 'Bands': [3085], 'resulting': [3086, 3328], 'radioactive': [3088], 'scanned': [3091], 'densitometry.': [3093], 'stripped': [3097], 'according': [3098, 3529], 'instructions': [3101, 3532], 'manufacturer': [3104, 3713], 'rehybridized': [3106, 4277], 'GAPDH': [3109, 3205], 'probe,': [3111, 4282], 'band': [3114], 'densities': [3115], 'normalized': [3117, 3201, 3741], 'signal.': [3120], 'For': [3121, 3477], 'mRNA': [3125, 3198, 4235, 4248, 4261, 4338, 4367], 'stability': [3126], 'studies,': [3127], '3': [3134, 3663, 4214, 4352], 'pretreatment.': [3138], 'Cells': [3139], 'incubated': [3143, 3275], '4': [3148], 'h.': [3149, 3834, 3873, 3914, 3934, 3981, 3994, 4243, 4272], 'At': [3150, 3915, 3935, 4244, 4257], 'time': [3151, 3938], '0,': [3152], 'DRB': [3153], '(20': [3154], 'inhibitor': [3157], 'transcription,': [3160], 'all': [3167], 'without': [3169, 3824, 4190], 'ng/ml)': [3174, 3360, 3691, 3829, 4197], 'intervals': [3177], 'indicated': [3178, 3218, 3422, 3699], 'Fig.': [3180, 3839, 4030, 4099, 4213], '4.': [3181], 'Abundance': [3182], 'quantified': [3190], 'Northern': [3192, 4163, 4209, 4359], 'blot': [3193, 3875, 4164, 4210, 4360], 'hybridization.': [3194], 'signals': [3199], 'levels.': [3206, 4256, 4312], 'proteins': [3208, 3255, 3366, 3879], 'solubilized': [3210], 'treatments': [3217], 'ice-cold': [3224], 'harvest': [3225], 'contained': [3227], '0.5%': [3228], 'Nonidet': [3229], 'P-40,': [3230], 'Tris-HCl': [3233], '8.0),': [3235], '10': [3237, 4062], 'μm': [3238], 'phenylmethylsulfonyl': [3239], 'fluoride.': [3240], 'Lysates': [3241], 'taken': [3243], 'up': [3244, 3831], 'Laemmli': [3246], 'SDS-PAGE,': [3251], 'separated': [3254], 'polyvinylidene': [3259], 'difluoride': [3260], '(Bio-Rad).': [3262], 'Primary': [3263], 'monoclonal': [3264], 'μg/ml,': [3272], 'Cayman)': [3273], 'membranes': [3278, 3287], '2': [3280, 3693], 'room': [3283], 'temperature.': [3284], 'Following': [3285], 'washes,': [3286], 'reincubated': [3289], 'secondary': [3291], 'peroxidase-labeled': [3292], 'antibodies.': [3293, 3814], 'experiments,': [3296], 'primary': [3297], 'detection': [3309, 3319], 'ECL': [3315], '(Amersham': [3316, 3475], 'Biosciences)': [3317], 'chemiluminescence': [3318], 'signals,': [3325], 'bands': [3329], 'analyzed': [3331], 'densitometer.': [3334], 'With': [3335, 3499, 3567, 3904], 'assessing': [3338], 'MAP': [3345], 'kinases,': [3346], 'lysates': [3348], 'SDS-PAGE;': [3364], 'probed': [3373], 'phospho-specific': [3375], 'grown': [3383], '24-well': [3387], 'cluster': [3389], 'FBS.': [3395, 3498], 'Monolayers': [3396], 'shifted': [3398, 3820, 4187], 'serum-free': [3400], 'final': [3404, 3451, 3937], '24': [3405, 3864, 3933, 3980, 4258], 'incubation.': [3408], 'times': [3419, 4202], 'concentrations': [3421], 'removed': [3429], 'cultures,': [3432], '(PBS)': [3441], 'presence': [3444], '30': [3452], 'min': [3453, 3639], 'period.': [3457], 'PBS': [3458], 'collected': [3460], 'quantitatively,': [3461], 'clarified': [3462], 'centrifugation,': [3464], 'using': [3470, 3606], 'commercially': [3472], 'available': [3473], 'kit': [3474, 3524], 'Biosciences).': [3476], 'involving': [3479], 'transient': [3481], 'transfection': [3482, 3629, 3677], 'fibroblasts,': [3485], 'proliferate': [3490], '80–90%': [3492], 'assessment': [3502], '510-bp': [3507], 'spanning': [3509], '−538': [3510], '−28': [3512], 'cloned': [3519], 'GenomeWalker': [3523], '(CLONTECH,': [3525], 'Palo': [3526], 'Alto,': [3527], 'CA)': [3528], 'supplier.': [3535], 'reverse': [3537], 'primers': [3538], 'PCR': [3542], 'reactions': [3543], 'included': [3544], '5′-CGCAGCTCAACTGTGGGTGTGATC-3′': [3545], '5′-GTGATCAGCTCGACAGAGGAGCAG-3′.': [3547], 'amplified': [3549], 'sequenced': [3552], 'subcloned': [3554], 'pCR2.1-TOPO': [3556], '(Invitrogen)': [3558], 'promoter-less': [3561], 'pGL2-luciferase': [3562], '(Promega,': [3564], 'Madison,': [3565], 'WI).': [3566], '−1840': [3579], '+123': [3581], 'thus': [3583], 'located': [3584], 'five': [3585], 'base': [3586], 'pairs': [3587], 'upstream': [3588], 'ATG': [3591], 'used.': [3598], 'Promoter': [3599], 'constructs': [3600, 3765], 'transiently': [3602, 3777], 'LipofectAMINE': [3608, 3644], 'PLUS': [3609, 3635, 3645], '(Invitrogen).': [3611, 3774], '0.75': [3612], 'μg': [3613, 3620], 'pGL2': [3615], 'DNA': [3617, 3624], '0.1': [3619], 'pRL-TK': [3622], '(Promega),': [3625], 'serving': [3626], 'efficiency': [3630], 'control,': [3631], 'mixed': [3633], 'reagent': [3636], '15': [3638, 3648], 'before': [3640], 'combined': [3642], 'another': [3647], 'min.': [3649], 'DNA-lipid': [3651], 'mixture': [3652, 3678], '80%': [3659], "Dulbecco's": [3668], 'modified': [3669], 'FBS': [3674, 4191], 'replaced': [3675], 'Transfected': [3680], 'serum-starved,': [3684], '(control)': [3697], 'material': [3705], 'harvested': [3707], '(Promega)': [3714, 3732], 'stored': [3716], '−80': [3718], 'until': [3720, 3979], 'assayed.': [3721], 'Luciferase': [3722], 'monitored': [3725], 'Dual-Luciferase': [3728], 'Reporter': [3729], 'Assay': [3730], 'System': [3731], 'FB12': [3735], 'tube': [3736], 'luminometer': [3737], '(Zylux).': [3738], 'Values': [3739], 'internal': [3743], 'controls,': [3744], 'experiment': [3747, 3942], 'performed': [3749], 'least': [3751, 3924, 4252], 'three': [3752], 'times.': [3753], 'To': [3754], 'interrupt': [3755], 'pathway': [3762], 'components,': [3763], 'ERK1': [3769], 'ligated': [3771], 'pcDNA3.1': [3773], 'above.': [3783], 'Control': [3784], 'constant': [3788, 4341], 'amount': [3789], '(2': [3790], 'μg)': [3791], 'empty': [3793], 'DNA.': [3795], 'diminished': [3797], 'kinases': [3801], 'documented': [3803], 'Western': [3805, 3874], 'blotting': [3806], 'aliquot': [3808], 'lysate': [3811], 'Confluent': [3815, 4184], 'serumless': [3822], 'As': [3835, 4207], 'data': [3837, 4028], 'Asuggest,': [3841], 'cytokine': [3843, 4069], 'increase': [3847], 'PGE2levels,': [3849], '90-fold': [3852], 'above': [3853, 3926, 4254, 4310], 'control': [3854, 3927, 4255, 4289, 4311], '6': [3857, 3913, 3968, 4242], 'h,': [3858, 3865, 3917, 4246, 4259, 4305, 4320], 'remain': [3859, 3930, 3987], 'near': [3860, 3921, 4035, 4118], 'peak': [3861, 3991], 'values': [3862], 'begin': [3868], 'decline': [3870], 'analysis': [3876, 4165, 4361], 'conditions': [3885, 4227, 4290], 'reveal': [3886], 'large,': [3888], 'time-dependent': [3889], 'detectable': [3899, 3911, 4223], 'basal': [3902, 4145, 4225], '12': [3916, 3970, 4245, 4304], 'maximal,': [3922], '100-fold': [3925, 4253], 'values,': [3928], 'elevated': [3931, 3966], 'point': [3939], '(48': [3943], 'h),': [3944], 'again': [3949, 4268], 'undetectable.': [3950], 'lags': [3955], 'behind': [3956], 'its': [3962], 'do': [3973], 'not': [3974, 4003, 4222], 'reach': [3975], 'apparent': [3977, 4287], 'maximum': [3978, 4302], 'Unlike': [3982], 'close': [3988], 'treatment.': [4010], 'effects': [4012, 4120], 'synthesis,': [4017], 'dose-dependent,': [4025], 'B': [4032], 'suggest.': [4033], 'maximal': [4036, 4119], 'effect': [4037, 4143, 4298], 'achieved': [4045], 'concentration': [4048, 4053, 4066, 4102], 'ng/ml.': [4051], 'That': [4052, 4101], 'yields': [4054], 'suboptimal': [4056], 'mPGES.': [4059, 4078], 'ng/ml,': [4063], 'highest': [4065], 'used,': [4070], 'considerably': [4074], 'higher': [4075], 'level': [4076], 'synthetic': [4094], 'nm,': [4098], '2).': [4100], 'fractional': [4110], 'occupancy': [4111], 'nuclear': [4114], 'glucocorticoid': [4115], 'receptor': [4116], 'metabolism': [4124], '(35.Smith': [4125], 'Metabolism.': [4127], '1988;': [4128], '37:': [4129], '179-184Abstract': [4130], 'no': [4142], 'IL-1β-dependent': [4151], 'accompanied': [4155], 'cytokine-provoked': [4161], 'PGE2production.': [4162], 'employed': [4167], 'determine': [4169], 'relationship': [4171], 'mRNAs.': [4183], 'overnight,': [4192], 'prior': [4203], 'monolayer': [4205], 'harvest.': [4206], 'indicates,': [4216], 'transcript': [4218, 4285], 'but': [4228], 'single,': [4233], '4.8-kb': [4234], 'addition': [4238, 4344], 'within': [4241], 'dropped': [4264], 'substantially': [4265], 'undetectable': [4269], 'When': [4273], '2-kb': [4284], 'strongly': [4293], 'up-regulated': [4294], 'reached': [4300], '∼7-fold': [4309], 'partially': [4316], 'sustained': [4317], 'duration': [4322], 'study,': [4325], 'remained': [4328], 'increased': [4329], '2.7-fold.': [4331], 'Steady-state': [4332], 'relatively': [4340], '(Fig.': [4351], 'A).': [4353], 'single': [4364], 'band.': [4365], 'm': [4368]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082457469', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-27T03:05:04.816628', 'created_date': '2016-06-24'}