Title: The V<sub>χ</sub> genes of the L regions and the repertoire of V<sub>χ</sub> gene sequences in the human germ line
Abstract: Abstract Only 14 of the 25 V χ genes and pseudogenes had been found before as parts of the L regions. The cloning and linking described in the accompanying report allowed us now to assign to Lp or Ld some V χ genes which had been found before on scattered clones. In addition the sequences of several still unknown genes are reported here, thus completing the publication of the V χ genes of the x locus as far as they are potentially functional or have only one or two 1‐bp defects. Of the V χ genes of the K locus, 32 are potentially functional, 16 have minor defects, 3 have both potentially functional and slightly defective alleles and 25 are pseudogenes which amounts to a repertoire of 76 V χ ‐related gene sequences. The V χ genes of the L regions are, within the subgroups, particularly similar to each other, which is in part due to common evolutionary origins and in part caused by gene conversion‐like events. One donor‐acceptor pair could be clearly identified, since converted and not‐converted alleles of the acceptor gene were found. In other cases the duplicates of the converted genes served as non‐converted controls.
Publication Year: 1993
Publication Date: 1993-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 62
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