Publication Information

{'id': 'https://openalex.org/W2082283951', 'doi': 'https://doi.org/10.1038/emm.2007.58', 'title': 'Signaling pathway for 2,3,7,8-tetrachlorodibenzo- p-dioxin-induced TNF-α production in differentiated THP-1 human macrophages', 'display_name': 'Signaling pathway for 2,3,7,8-tetrachlorodibenzo- p-dioxin-induced TNF-α production in differentiated THP-1 human macrophages', 'publication_year': 2007, 'publication_date': '2007-08-01', 'ids': {'openalex': 'https://openalex.org/W2082283951', 'doi': 'https://doi.org/10.1038/emm.2007.58', 'mag': '2082283951', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17934341'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/emm.2007.58', 'pdf_url': 'https://www.nature.com/articles/emm200758.pdf', 'source': {'id': 'https://openalex.org/S57588113', 'display_name': 'Experimental & Molecular Medicine', 'issn_l': '1226-3613', 'issn': ['1226-3613', '2092-6413'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 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111, 204, 232], 'aryl': [85], 'receptor': [87], '(AhR)': [88], 'inhibitor,': [89, 108, 113, 140, 234], 'prevented': [90, 168, 211], 'at': [96], 'levels.': [101], 'Genistein,': [102], 'tyrosine': [105], 'kinase': [106], '(PTK)': [107], 'PD153035,': [110, 231], 'EGFR': [112, 127, 147, 160, 179, 233, 253, 274, 296], 'also': [114], 'blocked': [115], 'increase': [117], 'by': [121, 219, 247, 251, 262], 'TCDD,': [122, 220], 'indicating': [123], 'role': [125], 'expression.': [131, 146], 'On': [132], 'other': [134], 'hand,': [135], 'PP2,': [136], 'c-Src': [138], 'specific': [139], 'did': [141], 'affect': [143], 'phosphorylation': [148], 'was': [149, 162, 171, 195, 249], 'detected': [150], 'early': [152], '5': [154], 'min': [155, 199], 'after': [156, 189, 200], 'treatment.': [158, 202], 'activation': [161, 180, 246, 272, 293], 'AhR-dependent': [163, 269], 'since': [164], 'co-treatment': [165], 'with': [166], 'α-NF': [167, 238], 'it.': [169], 'ERK': [170, 194, 241, 245], 'found': [172], 'downstream': [176], 'effector': [177], 'leading': [185, 299], 'production': [188, 261], 'stimulation.': [191], 'Activation': [192], 'observed': [196], '30': [198], 'PD98059,': [203], 'inhibitor': [205], 'MEK-ERK': [208], 'pathway,': [209], 'completely': [210], 'whereas': [221], 'inhibitors': [222], 'JNK': [224], 'p38': [226, 282], 'MAPK': [227], 'had': [228], 'no': [229], 'effect.': [230], 'well': [236], 'significantly': [239], 'reduced': [240], 'phosphorylation,': [242], 'suggesting': [243], 'mediated': [250], 'AhR.': [255], 'These': [256], 'results': [257], 'indicate': [258], 'differentiated': [265], 'macrophages': [267], 'involves': [271], 'ERK,': [276, 298], 'but': [277], 'c-Src,': [279], 'JNK,': [280], 'nor': [281], 'MAPK.': [283], 'A': [284], 'proposed': [288], 'where': [289], 'induces': [291], 'sequential': [292], 'AhR,': [295], 'increased': [302], 'TNF-α.': [305]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082283951', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-07T23:32:07.687764', 'created_date': '2016-06-24'}