Title: In Vivo Changes in γ‐Aminobutyric Acid Output from the Cerebral Cortex Induced by Inhibitors of γ‐Aminobutyric Acid Uptake and Metabolism
Abstract: Abstract: The effects of inhibitors of γ‐aminobutyric acid (GABA) metabolism or uptake on GABA output from the cerebral cortex was studied by means of a collecting cup placed on the exposed cortex of rats anaesthetized with urethane. GABA was identified and quantified by a mass‐fragmentographic method. Ethanolamine‐O‐sulphate (10 −2 M ) applied directly on the cerebral cortex caused a long‐lasting twofold increase in GABA output, whereas dl ‐2, 4‐diaminobutyric acid (5 × 10 −3 M ) caused a sevenfold increase and β ‐alanine was inactive. The results indicate that glial uptake has little effect on GABA inactivation in the cerebral cortex. The inhibition of neuronal uptake seems a more effective tool to increase GABA concentration in the synaptic cleft, and consequently also in GABA output, than the inhibition of GABA metabolism.
Publication Year: 1982
Publication Date: 1982-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 11
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