Paxillin Is Tyrosine-phosphorylated by and Preferentially Associates with the Calcium-dependent Tyrosine Kinase in Rat Liver Epithelial Cells

Name: Work Video:
Duration: 3 min 30 s
Xiong Li; H. Shelton Earp
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4357], 'these': [42, 386, 2146], 'related': [43, 387, 1679], 'enzymes': [44, 268, 388, 612, 2147, 2713], 'in': [45, 65, 76, 153, 177, 218, 224, 250, 264, 283, 299, 315, 334, 339, 389, 409, 420, 497, 521, 562, 568, 594, 608, 627, 643, 659, 678, 683, 723, 1057, 1062, 1077, 1575, 2068, 2154, 2245, 2291, 2297, 2427, 2708, 2710, 2740, 2809, 2905, 2958, 3107, 3148, 3188, 3218, 3230, 3250, 3408, 3476, 3750, 3832, 4109, 4404], 'GN4': [46, 67, 133, 197, 211, 300, 390, 411, 477, 541, 555, 644, 2813, 2906, 3109, 3149, 3189, 4156, 4173], 'rat': [47, 301, 391, 645, 1009, 1298, 1449, 2428, 2463, 3355], 'liver': [48, 302, 392, 646, 1010, 1299, 2464, 2907, 3400, 4387], 'epithelial': [49, 303, 335, 393, 647, 679, 1011, 1300, 2298, 2465, 2908, 3401, 4388], 'cells': [50, 212, 304, 336, 394, 556, 648, 680, 1012, 1201, 1301, 2299, 2302, 2412, 2449, 2466, 2709, 2909, 3110, 3402, 3458, 3523, 3942, 3957, 4112, 4174, 4389], 'express': [52, 396, 2253, 2450, 2467, 4390], 'CADTK': [53, 72, 82, 90, 121, 195, 209, 258, 276, 289, 307, 317, 397, 416, 426, 434, 465, 539, 553, 602, 620, 633, 651, 661, 1374, 1479, 2254, 2407, 2468, 2471, 2719, 2834, 2904, 3112, 3145, 3167, 3181, 3194, 3338, 3858, 4209, 4295], 'p125FAK': [55, 60, 123, 139, 260, 320, 399, 404, 467, 483, 604, 664, 1481, 1805, 1823, 1846, 1906, 2077, 2112, 2136, 2239, 2618, 2741, 2815, 2880, 3100, 3143, 3169, 3911, 4094, 4392, 4405], 'at': [56, 325, 400, 669, 1807, 2457, 3660, 3667, 3697, 3844, 4187, 4200, 4236, 4243, 4372], 'roughly': [57, 401], 'similar': [58, 402, 3147], 'levels.': [59, 327, 403, 671], 'is': [61, 73, 92, 204, 405, 417, 436, 548, 1488, 1496, 1513, 1573, 1668, 1815, 2289, 2295, 2408, 2472, 2612, 2619, 2721, 2728, 2825, 2835, 2882, 2895, 2953, 3093, 3114, 4350], 'nearly': [62, 406], 'fully': [63, 407], 'tyrosine-phosphorylated': [64, 408, 2135, 3142, 4079], 'resting': [66, 410], 'cells.': [68, 412, 2431], 'In': [69, 113, 131, 186, 281, 297, 413, 457, 475, 530, 625, 641, 1803, 2614, 2877, 3070, 3678, 4263], 'contrast,': [70, 414], 'while': [71, 415, 4234], 'not': [74, 103, 223, 246, 319, 418, 447, 567, 590, 663, 1676, 1825, 2108, 2252, 2284, 2409, 2601, 2896, 2911, 3162, 4211, 4319], 'tyrosine-autophosphorylated': [75, 419], 'untreated': [77, 421], 'cells,': [78, 134, 266, 286, 422, 478, 610, 630, 2617, 2814, 3150, 3190], 'angiotensin': [79, 165, 423, 509, 1133, 1275], 'II': [80, 166, 424, 510, 1134, 1276, 2831, 3077, 3223, 3989, 4100, 4170, 4214, 4247, 4330, 4398], 'increases': [81, 425, 1182, 2957, 3196, 4417], 'Tyr(P)': [83, 427, 1031, 1066, 4097, 4285, 4343], 'by': [84, 341, 428, 685, 1093, 1132, 1198, 2424, 2475, 2622, 2829, 2837, 3170, 3220, 3284, 3328, 3469, 3658, 3689, 3701, 3722, 3765, 3921, 3973, 3976, 4179, 4278, 4346, 4369, 4379], '5–10-fold.': [85, 429], 'With': [86, 430], 'regard': [87, 431], 'to': [88, 124, 278, 323, 432, 468, 622, 667, 701, 714, 733, 1065, 1080, 1090, 1515, 1552, 1577, 1680, 2075, 2078, 2421, 2596, 3236, 3343, 3543, 3676, 3757, 3760, 3821, 3946, 4104, 4265, 4312, 4365, 4400, 4415], 'activation': [91, 435, 1121, 2611, 2881, 2902, 3131, 3192], 'correlated': [93, 141, 310, 437, 485, 654, 1670, 2883, 2954], 'stimulation': [95, 106, 305, 439, 450, 649, 1081, 2717, 2737, 2885, 3126, 4215], 'c-Jun': [97, 441, 2959], 'N-terminal': [98, 442, 2960], 'p70S6Kpathways': [101, 445], 'but': [102, 222, 272, 318, 446, 566, 616, 662, 1672, 1831, 2952, 4301, 4318], 'mitogen-activated': [108, 452, 1270], 'protein': [109, 159, 453, 503, 995, 1017, 1085, 1187, 1271, 1378, 2485, 2592, 2608, 3214, 3672, 3707, 3710], 'or': [111, 167, 455, 511, 1138, 1674, 1828, 2023, 2453, 2484, 3404, 3597, 3709, 3810, 3983, 4228, 4368], 'p90RSK.': [112, 456], 'this': [114, 458, 3071, 4384], 'report': [115, 459, 3074], 'we': [116, 244, 460, 588, 2417, 3073, 4150], 'assessed': [117, 461, 4345], 'contribution': [119, 463], 'phosphorylation': [126, 156, 180, 203, 238, 470, 500, 524, 547, 582, 851, 1274, 2823, 3061, 3082, 3092, 3106, 3122, 3216, 3995, 4108, 4178, 4196, 4207, 4224, 4277, 4297, 4371, 4407], 'focal': [128, 472, 983, 1255, 1516, 2016, 2028, 2064, 2079, 2113, 2152], 'contact': [129, 473], 'proteins.': [130, 474], 'adherent': [132, 476, 2810, 3108], 'constitutive': [136, 480], 'activity': [137, 481, 1075, 2720, 3113, 4410], 'was': [140, 160, 181, 308, 321, 484, 504, 525, 652, 665, 1122, 3224, 3269, 3302, 3325, 3488, 3539, 3687, 3729, 3860, 3903, 3918, 4081, 4161], 'basal': [143, 487, 2819, 3103], 'paxillin,': [144, 271, 488, 615, 3084, 3982, 4266], 'tensin,': [145, 489, 3085], 'p130CAS': [147, 491, 1920, 4257, 4270, 4308, 4320], 'phosphorylation.': [149, 493, 4262], 'A': [150, 494, 3708], 'rapid': [151, 495, 3117], 'increase': [152, 176, 496, 520, 3992, 4105], 'each': [158, 502], 'detected': [161, 505, 3764, 4199, 4235], 'after': [162, 506, 1025, 3124], 'treatment': [163, 507, 1007, 3078, 4171, 4248, 4331], 'other': [168, 512, 1851, 2149, 2455, 2625], 'agonists': [169, 513, 2426, 3526], 'stimulate': [171, 515], 'CADTK;': [172, 516], 'prolonged': [174, 518], '3–4-fold': [175, 519], 'paxillin': [178, 201, 312, 324, 522, 545, 656, 668, 2032, 2053, 2070, 2105, 3091, 3104, 3120, 3151, 3179, 3197, 4096, 4106, 4176, 4218, 4359], 'most': [183, 527, 2242, 3095], 'substantial': [184, 528, 2956], 'change.': [185, 529], 'WB': [188, 532, 2811], 'cell': [189, 198, 227, 533, 542, 571, 693, 716, 724, 1819, 2248, 2460, 3531, 3626, 3685, 4157], 'line': [190, 199, 534, 543], 'expresses': [192, 536], '3-fold': [193, 537], 'less': [194, 538], 'than': [196, 540, 2738, 4315], 'agonist-dependent': [200, 331, 544, 675], 'similarly': [205, 549], 'reduced.': [206, 550], 'Immunoprecipitation': [207, 551, 4163], 'from': [210, 554, 1297, 2411, 3226, 3243, 3262, 3271, 3304, 3314, 4412], 'revealed': [213, 557, 3174, 4167], 'CADTK·paxillin': [214, 558], 'complexes': [215, 231, 249, 287, 559, 575, 593, 631, 2025, 3160, 3719, 3737], 'persisted': [217, 561, 4185], '500': [219, 563, 3682], 'mm': [220, 564, 3232, 3552, 3555, 3563, 3566, 3577, 3580, 3588, 3591, 3603, 3606, 3614, 3836], 'NaCl': [221, 565], '0.1%': [225, 569, 3619], 'SDS': [226, 570], 'lysis': [228, 572, 3487, 3532, 3537, 3549, 3600, 3627, 3745], 'buffer.': [229, 573, 3533, 3753], 'The': [230, 574, 688, 1072, 1490, 2050, 2286, 2900, 3088, 3856, 3929, 4231, 4335], 'were': [232, 261, 295, 576, 605, 639, 3241, 3260, 3281, 3312, 3341, 3406, 3466, 3527, 3632, 3656, 3720, 3738, 3755, 3804, 3830, 3936, 3958, 3971], 'largely': [233, 577], 'independent': [234, 578], 'state': [239, 583], 'either': [241, 253, 585, 597, 2481, 3807], 'protein.': [242, 586], 'Surprisingly,': [243, 587], 'did': [245, 589], 'detect': [247, 591], 'p125FAK·paxillin': [248, 592], 'immunoprecipitates': [251, 595], 'using': [252, 596, 2480, 3817], 'two': [255, 599, 2057, 3344], 'p125FAKantibodies.': [256, 600], 'When': [257, 601, 1842, 3827], 'transiently': [262, 606], 'overexpressed': [263, 607], '293(T)': [265, 285, 609, 629, 3464, 3941], 'associated': [269, 613], 'avidity': [274, 618], 'appeared': [277, 621, 1089], 'be': [279, 623, 731, 1091, 1677, 2109, 2422, 2597, 3163, 4198], 'greater.': [280, 624], 'addition,': [282, 316, 626, 660], 'transfected': [284, 628, 3937, 3956], 'between': [288, 632], 'another': [291, 635, 3853], 'substrate,': [293, 637], 'p130CAS,': [294, 638], 'detected.': [296, 640, 3164], 'summary,': [298, 642, 1804], 'highly': [309, 653, 1483], 'phosphorylation;': [314, 658], 'complexed': [322, 666], 'detectable': [326, 670, 4414], 'This': [328, 672, 1665, 4287], 'suggests': [329, 673], 'cytoskeletal': [332, 676, 3063], 'changes': [333, 677, 2739, 3201], 'might': [337, 681], 'proceed,': [338, 682], 'part,': [340, 684, 1078, 3219], 'CADTK-dependent': [342, 686], 'mechanisms.': [343, 687], 'once': [689], 'separate': [690], 'fields': [691], 'signal': [696, 1098, 2479], 'transduction': [697], 'converged': [699], 'due': [700, 1079, 4364], 'number': [703], 'recent': [705], 'observations.': [706], 'Growth': [707], 'factors': [708], 'hormones': [710], 'are': [711, 1482, 2714, 3146, 3203, 4309], 'now': [712, 1290], 'regulate': [715], 'shape': [717], 'mobility;': [719], 'conversely,': [720], 'proteins': [721, 1547, 1835, 1854, 1918, 2030, 2150, 3348, 3997, 4080], 'involved': [722], 'attachment': [725], 'cytoskeleton': [727, 1555], 'formation': [728], 'can': [729, 1832, 1913], 'clearly': [730], 'induced': [732], 'generate': [734], 'intracellular': [735, 1128, 1183, 1205], 'signals': [736, 1681], '(1Hall': [737], 'A.': [738, 765, 890, 1171, 1239, 1534, 1633, 1948, 4038], 'Annu.': [739, 813, 832, 938, 2182, 2201], 'Rev.': [740, 814, 833, 939, 2183, 2202], 'Cell': [741, 783, 815, 834, 905, 940, 956, 1562, 1655, 1724, 1974, 2040, 2184, 2203, 2229, 3486, 3654, 4122], 'Biol.': [742, 784, 817, 836, 863, 942, 957, 1038, 1111, 1152, 1220, 1315, 1358, 1433, 1464, 1563, 1595, 1656, 1698, 1725, 1755, 1795, 1869, 1886, 1897, 1929, 1975, 1995, 2041, 2123, 2186, 2205, 2230, 2268, 2326, 2391, 2506, 2544, 2636, 2652, 2672, 2696, 2765, 2862, 2937, 2991, 3018, 3039, 3384, 3439, 3507, 3788, 3887, 4019, 4060, 4135, 4431], '1994;': [743, 785, 1564, 1700, 1781, 1887, 2654], '10:': [744, 1113, 1154, 1222, 4021], '31-54Crossref': [745], 'PubMed': [746, 759, 772, 788, 821, 840, 871, 894, 910, 923, 946, 961, 1046, 1115, 1156, 1175, 1224, 1243, 1325, 1368, 1404, 1443, 1474, 1538, 1567, 1603, 1614, 1637, 1660, 1706, 1729, 1765, 1784, 1873, 1901, 1933, 1952, 1979, 2005, 2045, 2095, 2128, 2190, 2209, 2234, 2278, 2336, 2363, 2401, 2516, 2554, 2581, 2644, 2660, 2682, 2704, 2775, 2802, 2872, 2947, 3001, 3022, 3049, 3394, 3449, 3517, 3798, 3897, 4023, 4042, 4070, 4127, 4145], 'Scopus': [747, 760, 773, 789, 822, 841, 895, 911, 924, 947, 962, 1116, 1157, 1176, 1225, 1244, 1326, 1369, 1405, 1444, 1475, 1539, 1568, 1615, 1638, 1661, 1730, 1766, 1785, 1799, 1902, 1934, 1953, 1980, 2006, 2046, 2096, 2129, 2191, 2210, 2235, 2279, 2337, 2364, 2402, 2517, 2555, 2582, 2683, 2776, 2803, 2873, 2948, 3002, 3023, 3050, 3395, 3450, 3518, 3799, 3898, 4024, 4043, 4071, 4146], '(768)': [748], 'Google': [749, 762, 775, 791, 824, 843, 872, 897, 913, 926, 949, 964, 1047, 1118, 1159, 1178, 1227, 1246, 1328, 1371, 1407, 1446, 1477, 1541, 1570, 1604, 1617, 1640, 1663, 1707, 1732, 1768, 1787, 1801, 1874, 1904, 1936, 1955, 1982, 2008, 2048, 2098, 2131, 2193, 2212, 2237, 2281, 2339, 2366, 2404, 2519, 2557, 2584, 2645, 2661, 2685, 2705, 2778, 2805, 2875, 2950, 3004, 3025, 3052, 3397, 3452, 3520, 3801, 3900, 4026, 4045, 4073, 4128, 4148], 'Scholar,': [750, 763, 776, 792, 825, 873, 898, 914, 950, 1160, 1228, 1605, 1618, 1641, 1708, 1733, 1769, 1788, 1875, 1890, 1937, 1956, 1983, 2194, 2213, 2340, 2367, 2520, 2558, 2646, 2662, 2686, 2779, 3005, 4027, 4046, 4129], '2Clark': [751], 'A.E.': [752], 'Brugge': [753, 1652], 'J.S.': [754, 1653, 1716, 2221], 'Science.': [755], '1995;': [756, 769, 818, 837, 943, 1317, 1401, 1435, 1466, 1726, 1757, 1796, 1870, 1898, 1949, 1976, 2092, 2125, 2187, 2206, 2231, 2270, 2360, 2393, 2508, 2578, 2674, 2799, 3019, 3441, 3509, 3790, 4062, 4124, 4137, 4433], '268:': [757, 2639, 2699], '233-239Crossref': [758], '(2816)': [761], '3Richardson': [764], 'Parsons': [766, 779, 856, 1526, 1558, 1588, 1650, 1882, 1893, 1925, 1992, 2037, 2120, 3287], 'J.T.': [767, 780, 857, 1527, 1559, 1589, 1651, 1883, 1894, 1926, 1993, 2038, 2121], 'BioEssays.': [768], '17:': [770], '229-236Crossref': [771], '(256)': [774], '4Schaller': [777], 'M.D.': [778, 829, 935, 1519, 1557, 1647, 1879, 1892, 2036, 2119, 2198], 'Curr.': [781, 1560], 'Opin.': [782, 1561], '6:': [786, 1565, 1797, 2126], '705-710Crossref': [787, 1566], '(495)': [790, 1569], '5Jockusch': [793], 'B.M.': [794, 2163], 'Bubeck': [795, 2164], 'P.': [796, 1389, 1779, 2165, 2348, 2566, 2787], 'Giehl': [797, 2166], 'K.': [798, 808, 1454, 1460, 1694, 1739, 1741, 1743, 1745, 1747, 2082, 2167, 2177, 2258, 2264], 'Kroemker': [799, 2168], 'M.': [800, 804, 806, 859, 1350, 1456, 1591, 1966, 1970, 2169, 2173, 2175, 2260, 2318, 2443, 2536, 2757, 2854, 2929, 2983, 3376, 3879], 'Moschner': [801, 2170], 'J.': [802, 812, 862, 955, 1037, 1314, 1357, 1399, 1421, 1432, 1463, 1594, 1654, 1697, 1723, 1754, 1973, 1994, 2039, 2089, 2171, 2181, 2228, 2267, 2325, 2358, 2379, 2390, 2505, 2543, 2576, 2630, 2635, 2651, 2671, 2688, 2695, 2764, 2797, 2861, 2936, 2990, 3031, 3038, 3383, 3438, 3506, 3787, 3886, 4059, 4121, 4134, 4430], 'Rothkegel': [803, 2172], 'Rudiger': [805, 2174], 'Schluter': [807, 2176], 'Stanke': [809, 2178], 'G.': [810, 1968, 2179], 'Winkler': [811, 2180], 'Dev.': [816, 835, 941, 2185, 2204], '11:': [819, 838, 944, 2188, 2207], '379-416Crossref': [820, 2189], '(430)': [823, 2192], '6Schwartz': [826, 2195], 'M.A.': [827, 933, 2196], 'Schaller': [828, 858, 934, 1590, 1646, 1878, 2035, 2118, 2197, 3293], 'Ginsberg': [830, 936, 2199], 'M.H.': [831, 937, 2200], '549-599Crossref': [839, 945, 2208], '(1469)': [842, 948, 2211], 'Scholar).': [844, 965, 1048, 1119, 1179, 1247, 1372, 1478, 1664, 1802, 1905, 2009, 2049, 2099, 2132, 2238, 2405, 2585, 2706, 2876, 3053, 3398, 3453, 3521, 3802, 4074], 'For': [845, 2807], 'example,': [846, 2808], 'integrins': [847], 'engagement': [848, 4092], 'stimulates': [849, 3079, 4093], '(7Kornberg': [852, 1584], 'L.': [853, 875, 1585, 1643, 2442], 'Earp': [854, 876, 1035, 1107, 1148, 1163, 1216, 1231, 1355, 1586, 2323, 2541, 2762, 2859, 2934, 2988, 3014, 3036, 3381, 3884, 4015, 4030], 'H.S.': [855, 877, 1036, 1108, 1149, 1164, 1217, 1232, 1303, 1356, 1587, 2324, 2494, 2542, 2763, 2860, 2935, 2989, 3015, 3037, 3382, 3427, 3495, 3776, 3885, 4016, 4031, 4048, 4419], 'Juliano': [860, 882, 1592, 1695], 'R.L.': [861, 883, 952, 1593, 1696], 'Chem.': [864, 1039, 1316, 1359, 1434, 1465, 1596, 1699, 1756, 1996, 2269, 2327, 2392, 2507, 2545, 2637, 2653, 2673, 2697, 2766, 2863, 2938, 2992, 3040, 3385, 3440, 3508, 3789, 3888, 4061, 4136, 4432], '1992;': [865, 920, 1172, 1240, 1535, 1597, 1611, 1634, 1657, 4039], '267:': [866, 1598], '23439-23442Abstract': [867, 1599], 'Full': [868, 1043, 1320, 1322, 1363, 1365, 1438, 1440, 1469, 1471, 1600, 1703, 1760, 1762, 2000, 2002, 2273, 2275, 2331, 2333, 2396, 2398, 2511, 2513, 2549, 2551, 2641, 2657, 2677, 2679, 2701, 2770, 2772, 2867, 2869, 2942, 2944, 2996, 2998, 3044, 3046, 3389, 3391, 3444, 3446, 3512, 3514, 3793, 3795, 3892, 3894, 4065, 4067, 4140, 4142], 'Text': [869, 1044, 1321, 1323, 1364, 1366, 1439, 1441, 1470, 1472, 1601, 1704, 1761, 1763, 2001, 2003, 2274, 2276, 2332, 2334, 2397, 2399, 2512, 2514, 2550, 2552, 2642, 2658, 2678, 2680, 2702, 2771, 2773, 2868, 2870, 2943, 2945, 2997, 2999, 3045, 3047, 3390, 3392, 3445, 3447, 3513, 3515, 3794, 3796, 3893, 3895, 4066, 4068, 4141, 4143], 'PDF': [870, 1045, 1324, 1367, 1442, 1473, 1602, 1705, 1764, 2004, 2277, 2335, 2400, 2515, 2553, 2643, 2659, 2681, 2703, 2774, 2871, 2946, 3000, 3048, 3393, 3448, 3516, 3797, 3896, 4069, 4144], '8Kornberg': [874], 'Turner': [878, 2631], 'C.': [879, 881, 1958, 1962, 2088], 'Prokop': [880, 1101, 1142, 1210, 4009], 'Proc.': [884, 1165, 1233, 1528, 1627, 1942, 4032], 'Natl.': [885, 1166, 1234, 1529, 1628, 1943, 4033], 'Acad.': [886, 1167, 1235, 1530, 1629, 1944, 4034], 'Sci.': [887, 1168, 1236, 1531, 1630, 1945, 4035, 4123], 'U.': [888, 1169, 1237, 1532, 1631, 1946, 4036], 'S.': [889, 954, 1170, 1238, 1383, 1411, 1417, 1423, 1533, 1632, 1710, 1947, 2215, 2342, 2369, 2375, 2381, 2439, 2560, 2668, 2781, 4037, 4133], '1991;': [891, 907], '88:': [892], '8392-8396Crossref': [893], '(632)': [896, 1662], '9Guan': [899], 'J.L.': [900, 916, 1607], 'Trevithick': [901], 'J.E.': [902, 1429, 2387], 'Hynes': [903], 'R.O.': [904], 'Regul.': [906], '2:': [908], '951-964Crossref': [909], '(473)': [912], '10Guan': [915, 1606], 'Shalloway': [917, 1608], 'D.': [918, 1344, 1419, 1609, 2312, 2377, 2530, 2751, 2848, 2923, 2977, 3033, 3370, 3873], 'Nature.': [919, 1400, 1610, 1780, 2359, 2577, 2798], '358:': [921, 1612], '690-692Crossref': [922, 1613], '(724)': [925, 1616], 'Scholar)': [927, 1329, 1542, 1571, 2282, 2951, 3901], 'alters': [929], 'gene': [930], 'expression': [931, 3133], '(6Schwartz': [932], '11Juliano': [951], 'Haskill': [953], '1993;': [958, 2042, 2638, 2698], '120:': [959], '577-585Crossref': [960], '(1540)': [963], 'Several': [966], 'years': [967], 'ago': [968], 'our': [969], 'laboratory': [970], 'noted': [971], 'EGF': [973], '1The': [974], 'abbreviations': [975], 'used': [976, 3540, 3730], 'are:': [977], 'EGFepidermal': [978], 'growth': [979, 1249, 2735], 'factorCADTKcalcium-dependent': [980], 'kinasep125FAKp125': [982], 'adhesion': [984, 1256, 2017, 2029, 2065], 'kinasep130CASp130': [986], 'Crk-associated': [987, 1260], 'substratep70S6Kp70': [988], 'ribosomal': [989, 992, 1263, 1267], 'S6': [990, 993, 1264, 1268], 'kinasep90RSKp90': [991], 'kinaseMAPKmitogen-activated': [994], 'kinaseTyr(P)tyrosine': [996], 'phosphorylationAng': [997], 'IIangiotensin': [998], 'IIBAPTA-AMbis-(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic': [999], 'tetraacetoxymethyl': [1001, 1279], 'esterMe2SOdimethyl': [1002], 'sulfoxidePAGEpolyacrylamide': [1003], 'gel': [1004, 1284, 4325, 4336, 4354], 'electrophoresisGTPγSguanosine': [1005], '5′-3-O-(thio)triphosphate': [1006, 1287], 'produced': [1013, 1131], 'several': [1014, 2027, 2459], 'waves': [1015], 'phosphorylation,': [1019, 1193, 3199], 'second': [1021, 3733], 'occurring': [1022], '∼30': [1023], 's': [1024, 4202, 4280], 'initial': [1027], 'accumulation': [1028], 'EGF-dependent': [1030, 1074, 1096], 'substrates': [1032, 1067], '(12McCune': [1033], 'B.K.': [1034], '1989;': [1040], '264:': [1041], '15501-15507Abstract': [1042], 'At': [1049], 'least': [1050, 2458, 4188], 'some': [1051, 2448, 3725], 'secondary': [1054], 'substrates,': [1055], 'those': [1056], 'p115–130-kDa': [1059], 'region,': [1060], 'corresponded': [1061], 'molecular': [1063, 4000], 'size': [1064], 'observed': [1068, 3123], 'following': [1069, 3630], 'integrin': [1070, 4091], 'cross-linking.': [1071], 'delayed': [1073], 'was,': [1076], 'soluble': [1084], 'activated': [1092, 1574, 2423, 2474], 'small': [1095], 'calcium': [1097, 1129, 1184, 1206, 2590], '(13Huckle': [1099, 1140, 1208, 4007], 'W.R.': [1100, 1141, 1162, 1209, 1230, 1305, 2496, 3429, 3497, 3778, 4008, 4029, 4050, 4421], 'C.A.': [1102, 1143, 1211, 1521, 4010], 'Dy': [1103, 1144, 1212, 1312, 1341, 2309, 2503, 2527, 2748, 2845, 2920, 2974, 3367, 3436, 3504, 3785, 3870, 4011, 4057, 4428], 'R.C.': [1104, 1145, 1213, 4012], 'Herman': [1105, 1146, 1214, 4013], 'B.': [1106, 1147, 1215, 1346, 1397, 1645, 1960, 2314, 2356, 2532, 2574, 2753, 2795, 2850, 2925, 2979, 3372, 3875, 4014], 'Mol.': [1109, 1150, 1218, 1793, 1867, 1884, 1895, 1927, 2122, 3016, 4017], 'Cell.': [1110, 1151, 1219, 1794, 1868, 1885, 1896, 1928, 2124, 3017, 4018], '1990;': [1112, 1153, 1221, 4020], '6290-6298Crossref': [1114, 1155, 1223, 4022], '(87)': [1117, 1158, 1226, 4025, 4147], 'Kinase': [1120], 'even': [1123, 3137, 4340], 'greater': [1124, 2725], 'higher': [1127], 'levels': [1130, 3140], '(Ang': [1135], 'II),': [1136], '[Arg8]vasopressin,': [1137], 'epinephrine': [1139], '14Huckle': [1161, 1229, 4028], '89:': [1173, 1241, 1536, 1635, 4040], '8837-8841Crossref': [1174, 1242, 4041], '(73)': [1177, 1245, 4044], 'Thapsigargin': [1180, 3238], 'which': [1181, 2711], 'without': [1185], 'stimulating': [1186], 'C': [1189, 2012, 2594, 2610], 'stimulated': [1191, 2621, 2836], 'an': [1194, 1204, 4182], 'effect': [1195, 1667, 2155, 2588, 3089, 4183], 'greatly': [1196], 'diminished': [1197], 'pretreatment': [1199], 'BAPTA-AM,': [1203], 'chelator': [1207], 'epidermal': [1248], 'factor': [1250, 2736], 'p125': [1254], 'p130': [1259], 'substrate': [1261, 1512], 'p70': [1262], 'p90': [1266], 'bis-(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic': [1277], 'ester': [1280], 'dimethyl': [1281], 'sulfoxide': [1282], 'polyacrylamide': [1283], 'electrophoresis': [1285], 'guanosine': [1286], 'purified': [1291, 2605], '(CADTK)': [1296], '(15Earp': [1302, 2493, 3426, 3494, 3775, 4418], 'Huckle': [1304, 2495, 3428, 3496, 3777, 4049, 4420], 'Dawson': [1306, 1347, 2315, 2497, 2533, 2754, 2851, 2926, 2980, 3373, 3430, 3498, 3779, 3876, 4051, 4422], 'T.L.': [1307, 1348, 2316, 2498, 2534, 2755, 2852, 2927, 2981, 3374, 3431, 3499, 3780, 3877, 4052, 4423], 'Li': [1308, 1337, 1420, 2305, 2378, 2499, 2523, 2744, 2841, 2916, 2970, 3010, 3034, 3363, 3432, 3500, 3781, 3866, 4053, 4424], 'X.': [1309, 1338, 1790, 2306, 2434, 2500, 2524, 2745, 2842, 2917, 2971, 3011, 3035, 3364, 3433, 3501, 3782, 3867, 4054, 4425], 'Graves': [1310, 1353, 2321, 2501, 2539, 2760, 2857, 2932, 2986, 3379, 3434, 3502, 3783, 3882, 4055, 4426], 'L.M.': [1311, 1354, 1425, 2322, 2383, 2502, 2540, 2761, 2858, 2933, 2987, 3027, 3380, 3435, 3503, 3784, 3883, 4056, 4427], 'R.': [1313, 1342, 1387, 1413, 2310, 2346, 2371, 2504, 2528, 2564, 2749, 2785, 2846, 2921, 2975, 3368, 3437, 3505, 3786, 3871, 4058, 4429], '270:': [1318, 1436, 1467, 1758, 2271, 2394, 2509, 2675, 3442, 3510, 3791, 4063, 4138, 4434], '28440-28447Abstract': [1319, 2510, 3443, 3511, 3792, 4064], '(64)': [1327, 2518, 3451, 3519, 3800, 4072], 'obtained': [1331], 'complete': [1333], 'cDNA': [1334, 3859], '(16Yu': [1335, 2303, 2742, 2839, 2914, 2968, 3361, 3864], 'H.': [1336, 1385, 1431, 1452, 1458, 1712, 1964, 1972, 2217, 2256, 2262, 2304, 2344, 2389, 2438, 2522, 2562, 2743, 2783, 2840, 2915, 2969, 3009, 3362, 3865], 'Marchetto': [1339, 2307, 2525, 2746, 2843, 2918, 2972, 3365, 3868], 'G.S.': [1340, 2308, 2526, 2747, 2844, 2919, 2973, 3366, 3869], 'Hunter': [1343, 1774, 2311, 2529, 2750, 2847, 2922, 2976, 3032, 3369, 3872], 'Calvo': [1345, 2313, 2531, 2752, 2849, 2924, 2978, 3371, 3874], 'Wilm': [1349, 2317, 2535, 2756, 2853, 2928, 2982, 3375, 3878], 'Anderegg': [1351, 2319, 2537, 2758, 2855, 2930, 2984, 3377, 3880], 'R.J.': [1352, 2320, 2538, 2759, 2856, 2931, 2985, 3378, 3881], '1996;': [1360, 1930, 1997, 2328, 2546, 2767, 2864, 2939, 2993, 3386, 3889], '271:': [1361, 1998, 2329, 2547, 2768, 2865, 2940, 2994, 3387, 3890], '29993-29998Abstract': [1362, 2330, 2548, 2769, 2866, 2941, 2995, 3388, 3891], '(248)': [1370, 2338, 2556, 2777, 2874, 2949, 3003, 3396, 3899], 'Rat': [1373, 3399, 4386], 'encodes': [1375], 'same': [1377], 'human': [1380, 3940], 'PYK2': [1381], '(17Lev': [1382], 'Moreno': [1384, 2343, 2561, 2782], 'Martinez': [1386, 2345, 2563, 2784], 'Canoll': [1388, 2347, 2565, 2786], 'Peles': [1390, 2349, 2567, 2788], 'E.': [1391, 2350, 2568, 2634, 2650, 2670, 2694, 2789], 'Musacchio': [1392, 2351, 2569, 2790], 'J.M.': [1393, 1924, 2352, 2570, 2791], 'Plowman': [1394, 2353, 2571, 2792], 'G.D.': [1395, 2354, 2572, 2793], 'Rudy': [1396, 2355, 2573, 2794], 'Schlessinger': [1398, 2357, 2575, 2796], '376:': [1402, 2361, 2579, 2800], '737-745Crossref': [1403, 2362, 2580, 2801], '(1253)': [1406, 2365, 2583, 2804], 'Scholar),': [1408, 1447, 4149], 'RAFTK': [1409], '(18Avraham': [1410], 'London': [1412, 2370], 'Fu': [1414, 2372], 'Y.': [1415, 1751, 1753, 2373, 2436, 3029], 'Ota': [1416, 2374], 'Hiregowdara': [1418, 2376], 'Jiang': [1422, 2380], 'Pasztor': [1424, 2382], 'White': [1426, 2384], 'R.A.': [1427, 2385], 'Groopman': [1428, 2386], 'Avraham': [1430, 2388], '27742-27751Abstract': [1437, 2395], '(325)': [1445, 2403], 'CAKβ': [1450], '(19Sasaki': [1451, 2255], 'Nagura': [1453, 2257], 'Ishino': [1455, 2259], 'Tobioka': [1457, 2261], 'Kotani': [1459, 2263], 'Sasaki': [1461, 2265], 'T.': [1462, 1737, 1749, 1775, 2084, 2266, 2648], '21206-21219Abstract': [1468, 2272], '(365)': [1476, 2280], 'related,': [1484], 'thus': [1486], 'comparison': [1487], 'instructive.': [1489], 'particularly': [1497], 'striking': [1498], 'within': [1499, 2061, 2151], 'C-terminal': [1504, 2063], 'domains.': [1505, 1841], 'p125FAK,': [1506, 3981], 'originally': [1507], 'identified': [1508, 4082], 'v-src': [1511], 'localized': [1514], 'adhesions': [1517, 2080], '(20Schaller': [1518], 'Borgman': [1520], 'Cobb': [1522, 1648], 'B.C.': [1523], 'Reynolds': [1524], 'A.B.': [1525], '5192-5196Crossref': [1537], '(1293)': [1540], 'where': [1543, 1813], 'network': [1545], 'connects': [1548], 'extracellular': [1550, 1582, 3211], 'matrix': [1551, 1583, 3212], 'actin': [1554], '(4Schaller': [1556], 'response': [1576], 'cellular': [1578], 'interaction': [1579, 3058], '21Hanks': [1619], 'S.K.': [1620, 1626, 1720, 1773, 1866, 1941, 2225], 'Calalb': [1621], 'M.B.': [1622, 1862], 'Harper': [1623], 'M.C.': [1624], 'Patel': [1625], '8487-8491Crossref': [1636], '(730)': [1639], '22Lipfert': [1642], 'Haimovich': [1644], 'B.S.': [1649, 1877], '119:': [1658], '905-912Crossref': [1659], 'latter': [1666, 2287], 'often': [1669], 'may': [1673, 1675, 2107, 2139, 4302, 4382], 'causally': [1678], 'activate': [1683, 2603, 2912], 'MAPK': [1685, 2888, 2913], 'pathway': [1686, 2889], '(23Chen': [1687], 'Q.': [1688], 'Kinch': [1689], 'M.S.': [1690], 'Lin': [1691], 'T.H.': [1692, 1881], 'Burridge': [1693, 3331], '269:': [1701, 2655], '26602-26605Abstract': [1702], '24Miyamoto': [1709, 2214], 'Teramoto': [1711, 2216], 'Coso': [1713, 2218], 'O.': [1714, 2219], 'Gutkind': [1715, 2220], 'Burbelo': [1717, 2222], 'P.D.': [1718, 2223], 'Akiyama': [1719, 2224], 'Yamada': [1721, 2226], 'K.M.': [1722, 2227, 4116], '131:': [1727, 2232], '791-805Crossref': [1728, 2233], '(1104)': [1731, 2236], '25Morino': [1734], 'N.': [1735, 2086, 2666], 'Mimura': [1736], 'Hamasaki': [1738], 'Tobe': [1740], 'Ueki': [1742], 'Kikuchi': [1744], 'Takehara': [1746], 'Kadowaki': [1748], 'Yazaki': [1750], 'Nojima': [1752], '269-273Abstract': [1759], '(261)': [1767], '26Schlaepfer': [1770], 'D.D.': [1771], 'Hanks': [1772, 1865, 1940], 'van': [1776], 'der': [1777], 'Geer': [1778], '372:': [1782], '786-791Crossref': [1783], '(1446)': [1786], '27Zhu': [1789], 'Assoian': [1791], 'R.K.': [1792], '273-282Crossref': [1798], '(392)': [1800], 'sits': [1806], 'conceptual': [1809], 'physical': [1811], 'juncture': [1812], 'it': [1814, 2420], 'capable': [1816], 'integrating': [1818], 'signaling.': [1822], 'does': [1824, 2251, 2600, 2910], 'contain': [1826], 'SH2': [1827, 1837, 1852], 'SH3': [1829, 1839, 1916], 'domains': [1830, 2060], 'interact': [1833, 1914], 'containing': [1836], 'binding': [1840, 1848, 2071], 'autophosphorylated': [1843], 'on': [1844, 3090, 3962, 4225], 'tyrosines,': [1845], 'creates': [1847], 'sites': [1849], 'for': [1850, 2111, 3180, 3664, 3694, 3715, 3731, 3847, 4186], 'domain-containing': [1853, 1917], 'including': [1855, 1919, 2031, 2462], 'Src': [1856, 2141], 'family': [1859, 2142], 'members': [1860], '(28Calalb': [1861], 'Polte': [1863], 'T.R.': [1864, 1939], '15:': [1871, 1888, 1899, 3020], '954-963Crossref': [1872], '29Cobb': [1876], 'Leu': [1880], '2819-2827Google': [1889], '30Schaller': [1891], '2635-2645Crossref': [1900], '(502)': [1903], 'exhibits': [1908, 2816], 'proline-rich': [1910], 'region': [1911], '(31Hildebrand': [1921], 'J.D.': [1922, 1987, 2034, 2117], 'Taylor': [1923, 4117], '16:': [1931], '3169-3178Crossref': [1932], '(296)': [1935], '32Polte': [1938], '92:': [1950], '10678-10682Crossref': [1951], '(388)': [1954], '33Guinebault': [1957], 'Payrastre': [1959], 'Racaud-Sultan': [1961], 'Mazarguil': [1963], 'Breton': [1965], 'Mauco': [1967], 'Plantavid': [1969], 'Chap': [1971], '129:': [1977], '831-842Crossref': [1978], '(224)': [1981], '34Harte': [1984], 'M.T.': [1985], 'Hildebrand': [1986], 'Burnham': [1988], 'M.R.': [1989], 'Bouton': [1990], 'A.H.': [1991], '13649-13655Abstract': [1999], '(323)': [2007], 'Additionally,': [2010], 'terminus': [2013], 'encompasses': [2014], 'targeting': [2018, 2066], 'forms': [2021, 3152], 'direct': [2022, 2598, 2892], 'indirect': [2024], '(35Hildebrand': [2033], '123:': [2043], '993-1005Crossref': [2044], '(359)': [2047], 'association': [2051, 2106], 'presumably': [2054], 'occurs': [2055], 'through': [2056], 'vinculin': [2058], 'homology': [2059], 'sequence;': [2067], 'turn,': [2069], 'has': [2072, 2240, 4101], 'been': [2073, 2241, 4102], 'suggested': [2074], 'localize': [2076], '(36Tachibana': [2081], 'Sato': [2083], "D'Avirro": [2085], 'Morimoto': [2087], 'Exp.': [2090], 'Med.': [2091], '182:': [2093], '1089-1100Crossref': [2094], '(239)': [2097], 'However,': [2100, 2406, 2707], 'reported': [2103], 'required': [2110], "adhesions'": [2114], 'localization': [2115], '(37Hildebrand': [2116], '637-647Crossref': [2127], '(310)': [2130], 'As': [2133, 3985], 'noted,': [2134], 'binds': [2137], '(and': [2138], 'activate)': [2140], 'kinases,': [2144], 'concentrating': [2145], 'adhesions,': [2153], 'assembling': [2156], 'large': [2158], 'signaling': [2160], 'complex': [2161, 3155], '(5Jockusch': [2162], 'extensively': [2243], 'fibroblasts,': [2246], 'type': [2249], '(data': [2283, 4210], 'shown).': [2285, 4212], 'abundant': [2290], 'neural': [2292], 'tissue': [2293], 'expressed': [2296, 2715], 'hematopoietic': [2301], '17Lev': [2341, 2559, 2780], '18Avraham': [2368], 'excluded': [2410], 'mesenchymal': [2414], 'origin': [2415], 'found': [2419], 'multiple': [2425], 'smooth': [2429, 4110], 'muscle': [2430, 4111], '2A.': [2432], 'Brinson,': [2433], 'Li,': [2435], 'He,': [2437], 'Earp,': [2440], 'Graves,': [2444], 'unpublished': [2445], 'results.': [2446], 'While': [2447, 3099], 'only': [2451, 2826], 'one': [2452, 4153], 'enzyme,': [2456], 'types': [2461], 'rapidly': [2473, 2620, 4250], 'Gq': [2477], 'protein-coupled': [2478], 'calcium-': [2483], 'C-dependent': [2487], 'branches': [2488], 'phospholipase': [2490], 'C-activated': [2491], 'pathways': [2492], '16Yu': [2521], 'Neither': [2586], 'nor': [2591], 'appear': [2595], '(calcium': [2599], 'directly': [2602], 'enzyme': [2606], 'slower).': [2613], 'Swiss': [2615], '3T3': [2616], 'bombesin': [2623], 'neuropeptides': [2626], '(38Zachary': [2627], 'I.': [2628, 2690, 3007, 4131], 'Sinnett-Smith': [2629], 'C.E.': [2632, 4114], 'Rozengurt': [2633, 2649, 2669, 2693], '22060-22065Abstract': [2640], '39Seufferlein': [2647], '9345-9351Abstract': [2656], '40Seckl': [2663], 'M.J.': [2664], 'Morii': [2665], 'Narumiya': [2667], '6984-6990Abstract': [2676], '(69)': [2684], '41Sinnett-Smith': [2687], 'Zachary': [2689], 'Valverde': [2691], 'A.M.': [2692], '14261-14268Abstract': [2700], 'more': [2722, 2730, 4241, 4288, 4310], 'rapid,': [2723], 'magnitude,': [2726], 'far': [2729], 'dependent': [2731], 'upon': [2732, 3206], 'hormonal': [2733, 3191], 'Scholar).2': [2806], 'high': [2818, 3573], 'level': [2820, 3209, 4274], 'minimally': [2827], 'increased': [2828, 3176, 4175, 4251], 'Ang': [2830, 3076, 3222, 3988, 4099, 4169, 4213, 4246, 4329, 4397], 'treatment,': [2832], 'whereas': [2833, 3158], '5–10-fold': [2838], 'many': [2878], 'instances': [2879], 'although': [2890], 'causal': [2893], 'relationship': [2894], 'universally': [2897], 'agreed': [2898], 'upon.': [2899], 'p70S6': [2964], '(p70S6K)': [2966], 'activities': [2967], '42Zohn': [3006], 'Yu': [3008], 'Cox': [3012], 'A.D.': [3013], '6160-6168Crossref': [3021], '(140)': [3024], 'Scholar,43Graves': [3026], 'He': [3028], 'Lambert': [3030], '1997;': [3041], '272:': [3042], '1920-1928Abstract': [3043], '(65)': [3051], 'But': [3054], 'what': [3055], "CADTK's": [3057], 'proteins,': [3064], 'dominant': [3066], 'feature': [3067], 'p125FAKbiology?': [3069], 'article': [3072], 'p130CAS.': [3087, 3984], 'dramatic': [3096], 'prolonged.': [3098], 'probably': [3101], 'regulates': [3102], '(since': [3111], 'minimal),': [3115], 'extensive': [3119], 'agonist': [3125], 'correlates': [3127], 'CADTK.': [3135, 4394], 'Moreover,': [3136], 'though': [3138, 4341], 'noncovalent': [3154], 'CADTK,': [3157, 3356, 3980], 'paxillin·p125FAK': [3159], 'could': [3161, 4197], 'Overexpression': [3165], 'transient': [3171], 'transfection': [3172], 'again': [3173], 'affinity': [3177], 'demonstrated': [3184], 'CADTK·p130CAS': [3185], 'complexes.': [3186], 'Thus,': [3187], 'significantly': [3195], 'acute': [3200], 'played': [3204], 'out': [3205], 'background': [3208], 'dictated': [3213], 'mediated,': [3217], 'purchased': [3225, 3242, 3261, 3270, 3303, 3313], 'Sigma': [3227, 3244], 'prepared': [3229, 3249], '50': [3231, 3565, 3590, 3845], 'acetic': [3233], 'prior': [3235, 3675], 'use.': [3237], 'BAPTA-AM': [3240], 'Biomol,': [3246], 'respectively,': [3247], 'Me2SO.': [3251], 'Anti-paxillin': [3252], 'monoclonal': [3253, 3257, 3266, 3274, 3323], 'antibody': [3254, 3258, 3267, 3275, 3279, 3324, 3693, 3734, 3772], 'anti-Tyr(P)': [3256, 4165], '(RC20H)': [3259], 'Transduction': [3263, 3315], 'Laboratories.': [3264], 'Anti-Tyr(P)': [3265], '(PT66)': [3268], 'Sigma.': [3272], 'Anti-p125FAK,': [3273], '2A7,': [3276], 'polyclonal': [3278, 3299, 3310, 3339], 'BC3': [3280], 'generously': [3282, 3326], 'provided': [3283, 3327, 3468, 3920], 'Drs.': [3285], 'Tom': [3286], '(University': [3288, 3294, 3332, 3925], 'Virginia)': [3290], 'Michael': [3292], 'North': [3296, 3334, 3927], 'Carolina).': [3297, 3335, 3928], 'Anti-p125FAK': [3298], 'antibody,': [3300], 'A17,': [3301], 'Santa': [3305, 3318], 'Cruz': [3306, 3319], 'Biotechnology.': [3307], 'Anti-p130CASmonoclonal': [3308], 'antibodies': [3311, 3814], 'Laboratories': [3316], 'Biotechnology,': [3320], 'respectively.': [3321], 'Anti-tensin': [3322], 'Dr.': [3329, 3470, 3922], 'Keith': [3330], 'Rabbit': [3336], 'anti-rat': [3337], 'antisera': [3340], 'raised': [3342], 'glutathione': [3345], 'S-transferase': [3346], 'fusion': [3347], '(amino': [3349], 'acids': [3350], '1–80': [3351], '680–860': [3353], 'respectively)': [3357], 'described': [3359, 3424, 3492, 3774, 3863], 'previously': [3360, 3493, 3986], '(GN4': [3403], 'WB)': [3405], 'cultured': [3407], "Richter's": [3409], 'minimal': [3410], 'essential': [3411], 'medium': [3412, 3480], 'supplemented': [3413], '10%': [3415, 3482, 3569, 3594, 3616], 'fetal': [3416, 3483], 'bovine': [3417, 3484], 'serum': [3418], '0.1': [3420], 'μm': [3421], 'insulin': [3422], 'earlier': [3425], 'Human': [3454, 3910], '293': [3455], 'embryonic': [3456], 'kidney': [3457], 'SV40': [3460], 'T': [3461], 'antigen': [3462], '(human': [3463], 'cells)': [3465], 'kindly': [3467, 3919], 'Brian': [3471], 'Varnum': [3472], '(Amgen)': [3473], 'grown': [3475], "Dulbecco's": [3477], 'modified': [3478], "Eagle's": [3479], 'serum.': [3485], 'performed': [3489], 'essentially': [3490], 'Briefly,': [3522], 'treated': [3524], 'scraped': [3528], 'into': [3529, 3905, 3914, 3938], 'ice-cold': [3530], 'One': [3534, 4075], 'three': [3536, 3741], 'buffers': [3538, 3628], 'referred': [3542], 'follows:': [3545], '(i)': [3546], 'low': [3547, 3965], 'salt': [3548, 3574, 3966], 'buffer': [3550, 3575, 3601, 3746, 3834], '(150': [3551, 3602], 'NaCl,': [3553, 3578, 3604], '20': [3554, 3579, 3605, 3638, 3704], 'Tris': [3556, 3607, 3837], '(pH': [3557, 3582, 3608, 3838], '7.5),': [3558, 3609], '1%': [3559, 3584, 3610], 'Triton': [3560, 3585, 3611], 'X-100,': [3561, 3586, 3612], '5': [3562, 3587, 4244], 'EDTA,': [3564, 3589, 3615], 'NaF,': [3567, 3592], '(v/v)': [3570, 3595, 3617], 'glycerol);': [3571, 3596], '(ii)': [3572], '(500': [3576], 'HEPES': [3581], '7.3),': [3583], '(iii)': [3598], 'RIPA': [3599], '2': [3613, 3695], 'glycerol,': [3618], 'SDS,': [3620, 3841], '0.5%': [3622], 'deoxycholate).': [3623], 'To': [3624], 'all': [3625], 'reagents': [3631], 'added': [3633], 'before': [3634], 'use:': [3635], '1': [3636, 3716, 4192, 4254, 4259, 4299, 4333], 'mmNa3VO4,': [3637], 'μg/ml': [3639, 3643], 'phenylmethylsulfonyl': [3640], 'fluoride,': [3641], '10': [3642, 3665], 'leupeptin,': [3644], '100': [3646, 3842], 'kallikrein': [3647], 'inhibitor': [3648], 'units': [3649], 'aprotinin': [3651], 'per': [3652], 'ml.': [3653], 'lysates': [3655, 3970], 'clarified': [3657], 'centrifugation': [3659, 3723], '14,000': [3661], '×': [3662], 'g': [3663], 'min': [3666, 4190], '4': [3668, 3698], '°C': [3669, 3846], 'content': [3673], 'determined': [3674], 'immunoprecipitation.': [3677], 'typical': [3680], 'experiment,': [3681], 'μg': [3683], 'lysate': [3686], 'immunoprecipitated': [3688], 'incubation': [3690], 'h': [3696], '°C,': [3699], 'followed': [3700, 3975, 4378], 'addition': [3702], 'μl': [3705], 'A/G-agarose': [3711], 'beads': [3712], '(Santa': [3713], 'Cruz)': [3714], 'h.': [3717], 'Immune': [3718, 3736], 'collected': [3721], '(in': [3724], 'cases': [3726], 'supernatant': [3728], 'immunoprecipitation).': [3735], 'then': [3739, 3748], 'washed': [3740], 'times': [3742], 'resuspended': [3749], 'SDS-PAGE': [3751], 'sample': [3752], 'Samples': [3754], 'subjected': [3756], 'SDS-PAGE,': [3758], 'transferred': [3759], 'Immobilon': [3761], '(Millipore),': [3762], 'incubating': [3766], 'blots': [3768], 'specified': [3771], 'Immunoblots': [3803], 'incubated': [3805], 'goat': [3808], 'anti-rabbit': [3809], 'anti-mouse': [3811], 'horseradish': [3812], 'peroxidase-conjugated': [3813], 'developed': [3816], 'enhanced': [3818], 'chemiluminescence': [3819], 'according': [3820, 3945], "manufacturer's": [3823, 3948], 'procedure': [3824, 3949], '(Amersham': [3825], 'Corp.).': [3826], 'indicated,': [3828], 'immunoblots': [3829], 'stripped': [3831], '(62.5': [3835], '6.8),': [3839], '2%': [3840], 'mmβ-mercaptoethanol)': [3843], '30': [3848, 4189], 'min,': [3849], 'reprobed': [3851], 'specific': [3854], 'antibody.': [3855], 'full-length': [3857], 'isolated': [3861], 'subcloned': [3904, 3913], 'pcDNA3': [3907, 3916], 'vector': [3908, 3931], '(Invitrogen).': [3909], 'cDNA,': [3912], 'vector,': [3917], 'William': [3923], 'Cance': [3924], 'control': [3930], '(pcDNA3),': [3932], 'pcDNA3-CADTK,': [3933], 'pcDNA3-p125FAK': [3935], 'subconfluent': [3939], 'LipofectAMINE': [3944], '(Life': [3950], 'Technologies,': [3951], 'Inc.).': [3952], 'After': [3953], '48': [3954], 'h,': [3955], 'harvested': [3959], 'lysed': [3961], 'ice': [3963], 'buffer,': [3967], 'analyzed': [3972], 'immunoprecipitation,': [3974], 'immunoblotting': [3977], 'anti-Tyr(P),': [3979], 'reported,': [3987], 'thapsigargin': [3991], 'weight': [4001], 'p115–130,': [4003], 'p72/75,': [4004], 'p66': [4006], '15Earp': [4047], '115-kDa': [4078], 'major': [4085], '(CADTK).': [4089], 'Since': [4090], 'shown': [4103], '(44Turner': [4113], 'Pietras': [4115], 'D.S.': [4118], 'Molloy': [4119], 'C.J.': [4120], '108:': [4125], '333-342Crossref': [4126], '45Leduc': [4130], 'Meloche': [4132], '4401-4404Abstract': [4139], 'tested': [4151], 'whether': [4152], 'p72/75-kDa': [4158], 'phosphoproteins': [4160], 'paxillin.': [4162, 4316], 'immunoblot': [4166, 4347], '90': [4180, 4279], 's,': [4181], '(Fig.': [4191, 4253, 4258, 4298, 4332], 'A).': [4193], 'Paxillin': [4194], '15–30': [4201], 'coincident': [4203], 'altered': [4217], 'electrophoretic': [4219], 'mobility,': [4220], 'suggesting': [4221], 'sequential,': [4222], 'multi-site': [4223], 'Tyr,': [4226], 'Ser,': [4227], 'Thr': [4229], 'residues.': [4230], 'mobility': [4232, 4326, 4337, 4355], 'shift,': [4233], 'early': [4237], 'time': [4238, 4292], 'points,': [4239], 'became': [4240], 'pronounced': [4242], 'min.': [4245], 'tensin': [4252, 4268, 4306, 4361], 'C)': [4255], 'E)': [4260], 'contrast': [4264], 'reached': [4271], 'their': [4272, 4284], 'maximum': [4273], 'gradually': [4282], 'decreased': [4283], 'content.': [4286], 'closely': [4289], 'parallels': [4290], 'course': [4293], 'G)': [4300], 'suggest': [4304], 'susceptible': [4311], 'phosphatases': [4314], 'Tensin': [4317], 'exhibited': [4322], 'significant': [4324], 'shift': [4327, 4338, 4356], 'C).': [4334], 'persists': [4339], 'total': [4342], 'recedes.': [4348], 'It': [4349], 'likely': [4351], 'progress': [4362], 'Ser/Thr': [4366], 'phosphorylations': [4367], 'new': [4373], 'sites.': [4374], 'Tryptic': [4375], 'phosphopeptide': [4376], 'mapping': [4377], 'phosphoamino': [4380], 'analysis': [4381], 'resolve': [4383], 'issue.': [4385], 'Stimulation': [4395], 'leads': [4399], 'variable': [4402], 'alteration': [4403], 'autokinase': [4409], 'ranging': [4411], 'barely': [4413], '50–100%': [4416], '284': [4435]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082218239', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-15T09:33:25.387385', 'created_date': '2016-06-24'}
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