Abstract:Recently there has been increasing recognition of hemorrhagic thrombocythemia as a clinical entity, although its status as a distinct pathological disorder is questioned. 1,2 Synonyms are essential th...Recently there has been increasing recognition of hemorrhagic thrombocythemia as a clinical entity, although its status as a distinct pathological disorder is questioned. 1,2 Synonyms are essential thrombocytosis, essential thrombophilia, thrombocythemia hemorrhagica, and hyperthrombotic myelosis. We concur with those who classify this disease with granulocytic leukemia, polycythemia vera, myeloid metaplasia, and myelosclerosis in the general category of myeloproliferative disorders. There may be no sharp dividing line between the different conditions; indeed, there are known cases of transformation from one form into another. Characteristic findings include recurrent episodes of hemorrhage and/or thrombosis, megakaryocytic hyperplasia of the marrow, and a striking increase in circulating platelets. Present in some, but not all, patients have been splenomegaly, neutrophilic leukocytosis, erythrocytosis, and a variety of coagulation defects, showing no consistent pattern. The interested reader is referred to several comprehensive reviews of the subject for further details. 1,3-7 The purpose of this report is to showRead More
Publication Year: 1963
Publication Date: 1963-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 11
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