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'colleagues.': [367], 'Learn': [368], 'more.Copy': [369], 'URL': [370], 'Abstract': [371], 'spectroscopy': [374, 780], 'has': [375], 'been': [376], 'used': [377], 'water': [380, 391, 420, 481, 487, 495, 500, 867, 917, 994, 1023, 1276, 1329], 'bound': [381, 472, 494], 'subtilisin': [383, 440, 1152], 'Carlsberg': [384, 1153], 'suspended': [385, 649], 'tetrahydrofuran': [387], '(THF),': [388], 'itself': [392], 'employed': [393], 'as': [394, 428, 485], 'probe': [396], "layer's": [400], 'physicochemical': [401], 'dynamic': [403, 841], 'characteristics.': [404], 'The': [405, 972, 991, 1147], 'presence': [406], 'did': [410], 'not': [411], 'affect': [412], 'intensity,': [414], 'chemical': [415, 1253], 'shift': [416, 1127], 'or': [417], 'linewidth': [418], '(up': [421], '8%': [423], 'v/v)': [424], 'added': [425], 'THF,': [427], 'measured': [429], '17O-': [431], '2H-NMR.': [433], 'This': [434, 492], 'finding': [435], 'suggests': [436], 'that': [437, 448, 478, 658], 'can': [441], 'be': [442, 498], 'described': [443], 'three-state': [446], 'model': [447], 'includes': [449], 'tightly': [450, 471], 'bound,': [451, 453], 'loosely': [452, 493], 'free': [455, 486], 'water.': [456, 473], 'Solid-state': [457, 686, 713], '2H-NMR': [458], 'spectra': [459], 'enzyme-bound': [461], 'D2O': [462], 'support': [463], 'existence': [465], 'non-exchanging': [468], 'population': [469], 'An': [474], 'important': [475], 'implication': [476], 'is': [477, 482], 'loosely-bound': [480], 'same': [484], 'from': [488, 866], 'viewpoint.': [491], 'must': [496], 'also': [497], 'responsible': [501], 'large': [504], 'increase': [505], 'catalytic': [507], 'activity': [508, 660, 845], 'observed': [509], 'previous': [511], 'studies.': [513], '©': [514], '1998': [515, 525], 'John': [516, 1356], '&': [518, 1358], 'Sons,': [519, 1359], 'Inc.': [520], 'Biotechnol': [521], 'Bioeng': [522], '57:': [523], '686–693,': [524], 'REFERENCES': [526], 'Affleck,': [527, 1364], 'R,': [528], 'Xu,': [529, 1362], 'Z.,': [530, 1118, 1363], 'Suzawa,': [531, 1286, 1368], 'V.,': [532, 1287, 1369], 'Focht,': [533], 'K.,': [534, 1015], 'D.': [536, 561, 564, 612, 643, 978, 1141, 1297, 1374], 'S.,': [537, 735, 860, 1295, 1372], 'J.': [539, 669, 697, 738, 761, 792, 824, 871, 880, 903, 921, 964, 1039, 1050, 1060, 1134, 1209, 1226, 1233, 1247, 1255, 1263, 1294, 1314, 1371, 1401], '1992.': [541, 614, 685, 794, 990, 1325], 'Enzymatic': [542, 1087, 1396], 'catalysis': [543, 1088, 1397], 'dynamics': [545, 579, 992], 'low-water': [547], 'environments.': [548], 'Proc.': [549], 'Natl.': [550], 'Acad.': [551], 'Sci.': [552, 1095], 'U.S.A.': [553], '89:': [554], '1100–': [555], '1104.': [556], 'Andrew,': [557], 'E.': [558, 567, 1165], 'R.,': [559, 570, 610, 765, 904, 1011, 1365], 'Bone,': [560], 'N.,': [562], 'Bryant,': [563], 'J.,': [565, 632, 636, 1142], 'Cashell,': [566], 'M.,': [568, 767], 'Gaspar,': [569], 'Meng,': [571], 'Q.': [572], '1982.': [574], 'Proton': [575, 911], 'relaxation': [576], 'studies': [577, 597, 1274], 'proteins': [581, 1349], 'solid': [584, 1333], 'state.': [585], 'Pure': [586], 'Appl.': [587], 'Chem.': [588, 671, 699, 785, 873, 923, 1006, 1051, 1136, 1180, 1257, 1316, 1403], '54:': [589], '585–': [590], '594.': [591], 'Belton,': [592], 'P.': [593, 609, 677, 704, 773, 827, 879, 1061, 1069, 1266], '1994.': [595, 881, 1376], 'protein': [599, 996, 1027, 1334], 'hydration.': [600], 'Prog.': [601, 803], 'Biophys.': [602, 851, 1005, 1038, 1339], 'Mol.': [603, 849], 'Biol.': [604, 698, 1402], '61:': [605], '61–': [606], '79.': [607], 'Bevington,': [608], 'Robinson,': [611], 'K.': [613, 764, 1190, 1324, 1345], 'Data': [615], 'reduction': [616], 'error': [618], 'analysis': [619], 'physical': [622], 'sciences,': [623], 'Chaps.': [624], '6–11.': [625], '2nd': [626], 'ed.': [627], 'McGraw-Hill,': [628, 1243], 'New': [629, 945, 1081, 1244, 1360], 'York.': [630, 946, 1082, 1245, 1361], 'Broos,': [631], 'Visser,': [633], 'A.,': [634, 641, 678, 705, 1227, 1264, 1322, 1391], 'Engbersen,': [635], 'Verboom,': [637], 'W.,': [638], 'van': [639], 'Hoek,': [640], 'Reinhoudt,': [642], 'N.': [644], '1995.': [645, 1166, 1210, 1299], 'Flexibility': [646], 'enzymes': [648, 796, 1103], 'solvents': [652, 1108, 1217], 'probed': [653], 'time-resolved': [655], 'fluorescence': [656], 'anisotropy–evidence': [657], 'enantioselectivity': [662], 'are': [663, 1102], 'directly': [664], 'related': [665, 1273], 'flexibility.': [668], 'Am.': [670, 872, 922, 1256, 1315], 'Soc.': [672, 874, 924, 1258, 1317], '117:': [673, 1318], '12657–': [674], '12663.': [675], 'Burke,': [676, 703], 'Griffin,': [679, 706], 'R.': [680, 707, 808], 'G.,': [681, 708, 1163, 1186, 1230], 'Klibanov,': [682, 709, 1083, 1098, 1392], 'M.': [684, 711, 769, 1046, 1085, 1100, 1202, 1394], 'assessment': [688], 'active': [691, 1105], 'center': [692], 'structure': [693, 1150], 'under': [694], 'nonaqueous': [695, 1399], 'conditions.': [696], '267:': [700], '20057–': [701], '20064.': [702], '1993.': [712], 'nuclear': [714, 1124, 1237], 'magnetic': [715, 778, 812, 869, 933, 958, 1125, 1175, 1238], 'resonance': [716, 779, 813, 934, 1126, 1176, 1312], 'investigation': [717], 'dependence': [720], 'tyrosyl': [722], 'ring': [723], 'motion': [724], 'enzyme.': [727], 'Biotechnol.': [728, 802, 1113, 1220, 1385], 'Bioeng.': [729, 1221, 1386], '42:': [730, 788], '87–': [731], '94.': [732], 'Chen,': [733], 'C.': [734, 737, 909], 'Sih,': [736], '1989.': [739, 1086], 'General': [740], 'aspects': [741], 'optimization': [743], 'enantioselective': [745], 'biocatalysis': [746, 885], 'solvents–the': [749], 'use': [750, 798], 'lipases.': [752], 'Angew.': [753], 'Chem.,': [754], 'Int.': [755], 'Ed.': [756], 'Engl.': [757], '28:': [758, 1182], '695.': [759], 'Davis,': [760], 'H.,': [762, 1267], 'Jeffrey,': [763], 'Bloom,': [766], 'Valic,': [768], 'I.,': [770], 'Higgs,': [771], '1976.': [774], 'Quadrupolar': [775], 'echo': [776], 'deuteron': [777], 'ordered': [782], 'hydrocarbon': [783], 'chains.': [784], 'Phys.': [786, 1135], 'Lett.': [787], '390–': [789], '394.': [790], 'Designing': [795], 'solvents.': [801, 920, 1092, 1400], '8:': [804], '259–': [805], '267.': [806], 'Dwek,': [807], '1973.': [810, 1047], 'Nuclear': [811, 932], '(NMR)': [814], 'biochemistry,': [816], 'pp.': [817, 940, 960, 1240, 1353], '37–': [818], '47.': [819], 'Clarendon': [820], 'Press,': [821, 944, 1080], 'Oxford.': [822], 'Finney,': [823], 'L.,': [825, 1290, 1292], 'Poole,': [826], 'L.': [828, 930, 985], '1984.': [829], 'Protein': [830, 864, 1158, 1167, 1192], 'activity:': [834], 'role': [836], 'hydration-induced': [838], 'conformation': [839], 'changes': [842], 'lysozyme.': [847], 'Comments': [848], 'Cell.': [850], '2:': [852, 1160], '129–': [853], '151.': [854], 'Halle,': [855], 'B.,': [856, 1044], 'Anderson,': [857], 'T.,': [858, 986, 1013], 'Forsén,': [859], 'Lindman,': [861], 'B.': [862, 965, 1205], '1981.': [863], 'oxygen-17': [868, 1252], 'relaxation.': [870, 1004], '103:': [875], '500–': [876], '508.': [877], 'Halling,': [878], 'Thermodynamic': [882, 1271], 'Predictions': [883], 'nonconventional': [887], 'media–theory,': [888], 'tests,': [889], 'recommendations': [891], 'experimental': [893], 'design': [894], 'analysis.': [896], 'Enzyme': [897], 'Microb.': [898], 'Technol.': [899], '16:': [900], '17.': [901], 'Holmes,': [902], 'Kivelson,': [905], 'D.,': [906, 1206], 'Drinkard,': [907], 'W.': [908, 1229], '1962.': [910], 'exchange': [912, 1020], 'rates': [913], 'hydrogen-bonding': [915], '84:': [925], '4677–': [926], '4686.': [927], 'James,': [928], '1975.': [931], 'biochemistry:': [936], 'Principles': [937], 'applications,': [939], '347–': [941], '363.': [942], 'Academic': [943, 1079], 'Jarrell,': [947], 'H.': [948, 1232], 'C.,': [949, 1203], 'Smith,': [950], 'I.': [951], '1983.': [952, 1062], 'Applications': [953], 'high': [955], 'resolution': [956, 1236], 'deuterium': [957, 1001, 1336], 'resonance,': [959, 1239], '133–': [961], '149.': [962], 'In:': [963, 1068], 'Lambert,': [966], 'F.': [968, 989], 'G.': [969, 1017, 1120, 1144, 1269], 'Riddel': [970], '(eds.),': [971], 'multinuclear': [973], 'approach': [974], 'spectroscopy.': [977, 1313], 'Reidel': [979], 'Publishing': [980], 'Co.,': [981], 'Boston,': [982], 'MA.': [983], 'Kakalis,': [984], 'Kumosinski,': [987], 'solutions–the': [997], 'field': [998], 'dispersion': [999], 'longitudinal': [1003], '43:': [1007, 1387], '39–': [1008], '49.': [1009], 'Kimmich,': [1010], 'Gneiting,': [1012], 'Kotitschke,': [1014], 'Schnur,': [1016], '1990.': [1018], 'Fluctuations,': [1019], 'processes,': [1021], 'diffusion': [1024], 'aqueous': [1026, 1129, 1195], 'systems–a': [1028], 'bovine': [1031], 'serum': [1032], 'albumin': [1033], 'diverse': [1035], 'techniques.': [1037], '58:': [1040], '1183–': [1041], '1197.': [1042], 'Kingston,': [1043], 'Symons,': [1045], 'Solvation': [1048], 'spectra.': [1049], 'Soc.,': [1052], 'Faraday': [1053], 'Trans.': [1054], '2,': [1055], '69:': [1056], '978–': [1057], '992.': [1058], 'Kintzinger,': [1059], 'Oxygen-17': [1063], 'NMR,': [1064], 'pp': [1065], '79–': [1066], '100.': [1067], 'Lazlo': [1070], '(ed.),': [1071], 'newly': [1074], 'accessible': [1075], 'nuclei,': [1076], 'Vol.': [1077], '2.': [1078], 'anhydrous': [1090], 'Trends': [1093, 1112], 'Biochem.': [1094], '14:': [1096], '141.': [1097], 'Why': [1101], 'less': [1104], 'than': [1109], 'water?': [1111], '15:': [1114], '97–': [1115], '101.': [1116], 'Luz,': [1117], 'Yagil,': [1119], '1966.': [1121], 'Water': [1122], '170': [1123], 'solutions': [1130], '1:1': [1132], 'electrolytes.': [1133], '70:': [1137], '554–': [1138], '561.': [1139], 'Neidhart,': [1140], 'Petsko,': [1143], '1988.': [1146, 1395], 'refined': [1148], 'crystal': [1149], 'at': [1154], '2.5': [1155], 'Å': [1156], 'resolution.': [1157], 'Eng.': [1159], '271.': [1161], 'Otting,': [1162, 1185], 'Liepinsh,': [1164, 1187], 'viewed': [1169], 'high-resolution': [1171], 'spectroscopy–implications': [1173], 'image': [1177], 'contrast.': [1178], 'Acc.': [1179], 'Res.': [1181], '171–': [1183], '177.': [1184], 'E.,': [1188], 'Wüthrich,': [1189, 1344], '1991.': [1191], 'solution.': [1196], 'Science': [1197], '254:': [1198], '974–': [1199], '980.': [1200], 'Parker,': [1201], 'Moore,': [1204], 'Blacker,': [1207], 'Measuring': [1211], 'nonpolar': [1215], 'using': [1218], 'NMR.': [1219, 1337], '46:': [1222], '452–': [1223], '458.': [1224], 'Pople,': [1225], 'Schneider,': [1228], 'Bernstein,': [1231], '1959.': [1234], 'High': [1235], '400–': [1241], '409.': [1242], 'Reuben,': [1246], '1969.': [1248], 'Hydrogen-bonding': [1249], 'effects': [1250], 'on': [1251], 'shifts.': [1254], '91:': [1259], '5725–': [1260], '5729.': [1261], 'Rupley,': [1262], 'Yang,': [1265], 'Tollin,': [1268], '1980.': [1270], 'interacting': [1277], 'proteins.': [1279], 'ACS': [1280], 'Symp.': [1281], 'Ser.': [1282], '127:': [1283], '111–': [1284], '132.': [1285], 'Khmelnitsky,': [1288], 'Y.': [1289], 'Giarto,': [1291], 'Suspended': [1300], 'immobilized': [1302], 'chymotrypsin': [1303], 'media–structure–function': [1306], 'relationships': [1307], 'revealed': [1308], 'electron': [1310], 'spin': [1311], '8435–': [1319], '8440.': [1320], 'Tamura,': [1321], 'Akasaka,': [1323], 'Quantitative': [1326], 'evaluation': [1327], 'content': [1330], 'Biochim.': [1338], 'Acta.': [1340], '1119:': [1341], '178–': [1342], '184.': [1343], '1986.': [1346], 'nucleic': [1351], 'acids,': [1352], '13–': [1354], '25.': [1355], 'Wangikar,': [1366], 'P.,': [1367], 'Transition': [1377], 'state': [1378], 'stabilization': [1379], 'subtilisins': [1381], 'media.': [1384], '515–': [1388], '520.': [1389], 'Zaks,': [1390], '263:': [1404], '8017–': [1405], '8021.': [1406], 'Citing': [1407], 'Literature': [1408], 'Volume57,': [1409], 'Issue620': [1410], '1998Pages': [1412], 'ReferencesRelatedInformation': [1414]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2081828211', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 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