Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2081637278', 'doi': 'https://doi.org/10.1016/0014-2999(88)90461-x', 'title': '‘GABA shift’ in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA', 'display_name': '‘GABA shift’ in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA', 'publication_year': 1988, 'publication_date': '1988-03-01', 'ids': {'openalex': 'https://openalex.org/W2081637278', 'doi': 'https://doi.org/10.1016/0014-2999(88)90461-x', 'mag': '2081637278', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2898371'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0014-2999(88)90461-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103717606', 'display_name': 'Lawrence G. Miller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Lawrence G. Miller', 'raw_affiliation_strings': ['Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'institution_ids': ['https://openalex.org/I1290900354']}, {'raw_affiliation_string': 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087737186', 'display_name': 'David J. Greenblatt', 'orcid': 'https://orcid.org/0000-0003-4719-6226'}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David J. Greenblatt', 'raw_affiliation_strings': ['Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'institution_ids': ['https://openalex.org/I1290900354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085918331', 'display_name': 'Jamie Barnhill', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jamie G. Barnhill', 'raw_affiliation_strings': ['Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'institution_ids': ['https://openalex.org/I1290900354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108822682', 'display_name': 'Warren R. Summer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Warren R. Summer', 'raw_affiliation_strings': ['Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'institution_ids': ['https://openalex.org/I1290900354']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055898939', 'display_name': 'Richard I. Shader', 'orcid': 'https://orcid.org/0000-0002-1888-7565'}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard I. Shader', 'raw_affiliation_strings': ['Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Pharmacology, LSU Medical Center, New Orleans, LA, U.S.A.', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts-New England Medical Center, Boston, MA, U.S.A.', 'institution_ids': ['https://openalex.org/I1290900354']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5103717606'], 'corresponding_institution_ids': ['https://openalex.org/I1290900354'], 'apc_list': {'value': 2790, 'currency': 'USD', 'value_usd': 2790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.385, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.81773, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '148', 'issue': '1', 'first_page': '123', 'last_page': '130'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13142', 'display_name': 'GABA and Rice Research', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10660', 'display_name': 'Conducting polymers and applications', 'score': 0.9864, 'subfield': {'id': 'https://openalex.org/subfields/2507', 'display_name': 'Polymers and Plastics'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aminooxyacetic-acid', 'display_name': 'Aminooxyacetic acid', 'score': 0.71580285}, {'id': 'https://openalex.org/keywords/aminobutyric-acid', 'display_name': 'Aminobutyric acid', 'score': 0.5851595}, {'id': 'https://openalex.org/keywords/pons', 'display_name': 'Pons', 'score': 0.48396495}, {'id': 'https://openalex.org/keywords/radioligand', 'display_name': 'Radioligand', 'score': 0.46247992}, {'id': 'https://openalex.org/keywords/gaba-receptor-antagonist', 'display_name': 'GABA receptor antagonist', 'score': 0.43517238}], 'concepts': [{'id': 'https://openalex.org/C2776627618', 'wikidata': 'https://www.wikidata.org/wiki/Q4746466', 'display_name': 'Aminooxyacetic acid', 'level': 3, 'score': 0.71580285}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6542373}, {'id': 'https://openalex.org/C2779414652', 'wikidata': 'https://www.wikidata.org/wiki/Q3604505', 'display_name': 'Aminobutyric acid', 'level': 3, 'score': 0.5851595}, {'id': 'https://openalex.org/C168258287', 'wikidata': 'https://www.wikidata.org/wiki/Q60147', 'display_name': 'GABAA receptor', 'level': 3, 'score': 0.5352809}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.53349906}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.52621007}, {'id': 'https://openalex.org/C2779652256', 'wikidata': 'https://www.wikidata.org/wiki/Q130983', 'display_name': 'Cerebellum', 'level': 2, 'score': 0.5231896}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5121832}, {'id': 'https://openalex.org/C2778897929', 'wikidata': 'https://www.wikidata.org/wiki/Q192570', 'display_name': 'Pons', 'level': 2, 'score': 0.48396495}, {'id': 'https://openalex.org/C67847695', 'wikidata': 'https://www.wikidata.org/wiki/Q626478', 'display_name': 'Radioligand', 'level': 3, 'score': 0.46247992}, {'id': 'https://openalex.org/C2777003273', 'wikidata': 'https://www.wikidata.org/wiki/Q164386', 'display_name': 'Hypothalamus', 'level': 2, 'score': 0.4387171}, {'id': 'https://openalex.org/C79636183', 'wikidata': 'https://www.wikidata.org/wiki/Q5512770', 'display_name': 'GABA receptor antagonist', 'level': 5, 'score': 0.43517238}, {'id': 'https://openalex.org/C2781161787', 'wikidata': 'https://www.wikidata.org/wiki/Q48360', 'display_name': 'Hippocampus', 'level': 2, 'score': 0.42722613}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.42070466}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.38367403}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37012625}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26223898}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26156867}, {'id': 'https://openalex.org/C2780763569', 'wikidata': 'https://www.wikidata.org/wiki/Q3639734', 'display_name': 'Bicuculline', 'level': 4, 'score': 0.15885988}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07492381}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D014151', 'descriptor_name': 'Anti-Anxiety Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005680', 'descriptor_name': 'gamma-Aminobutyric Acid', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000625', 'descriptor_name': 'Aminooxyacetic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000625', 'descriptor_name': 'Aminooxyacetic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014151', 'descriptor_name': 'Anti-Anxiety Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014151', 'descriptor_name': 'Anti-Anxiety Agents', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002998', 'descriptor_name': 'Clonazepam', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002998', 'descriptor_name': 'Clonazepam', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008815', 'descriptor_name': 'Mice, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005680', 'descriptor_name': 'gamma-Aminobutyric Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0014-2999(88)90461-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2898371', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.56, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1596858235', 'https://openalex.org/W1952263078', 'https://openalex.org/W1970932556', 'https://openalex.org/W1980373801', 'https://openalex.org/W1983005831', 'https://openalex.org/W199747169', 'https://openalex.org/W2001583156', 'https://openalex.org/W2013777017', 'https://openalex.org/W2014066806', 'https://openalex.org/W2016049265', 'https://openalex.org/W2027697549', 'https://openalex.org/W2037329129', 'https://openalex.org/W2039567642', 'https://openalex.org/W2039884272', 'https://openalex.org/W2057981021', 'https://openalex.org/W2061838360', 'https://openalex.org/W2063040073', 'https://openalex.org/W2063864024', 'https://openalex.org/W2068002203', 'https://openalex.org/W2081934761', 'https://openalex.org/W2085032201', 'https://openalex.org/W2111997215', 'https://openalex.org/W2266927181', 'https://openalex.org/W2315169175', 'https://openalex.org/W2328906651', 'https://openalex.org/W2470603893'], 'related_works': ['https://openalex.org/W2419592824', 'https://openalex.org/W2229920019', 'https://openalex.org/W2150066672', 'https://openalex.org/W2077670383', 'https://openalex.org/W2061350986', 'https://openalex.org/W2031381279', 'https://openalex.org/W1990971574', 'https://openalex.org/W1971977240', 'https://openalex.org/W1947062114', 'https://openalex.org/W150129925'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2081637278', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T23:27:20.153356', 'created_date': '2016-06-24'}