Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2081524260', 'doi': 'https://doi.org/10.1161/01.cir.103.2.196', 'title': 'Mutations in the Cardiac Ryanodine Receptor Gene ( <i>hRyR2</i> ) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia', 'display_name': 'Mutations in the Cardiac Ryanodine Receptor Gene ( <i>hRyR2</i> ) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia', 'publication_year': 2001, 'publication_date': '2001-01-16', 'ids': {'openalex': 'https://openalex.org/W2081524260', 'doi': 'https://doi.org/10.1161/01.cir.103.2.196', 'mag': '2081524260', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11208676'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.cir.103.2.196', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1161/01.cir.103.2.196', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008966758', 'display_name': 'Silvia G. Priori', 'orcid': 'https://orcid.org/0000-0001-6877-0288'}, 'institutions': [{'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}, {'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210094195', 'display_name': 'Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda', 'ror': 'https://ror.org/00htrxv69', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094195']}, {'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia G. Priori', 'raw_affiliation_strings': ['Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).'], 'affiliations': [{'raw_affiliation_string': 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'institution_ids': ['https://openalex.org/I4210105320', 'https://openalex.org/I25217355']}, {'raw_affiliation_string': 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'institution_ids': ['https://openalex.org/I292310028']}, {'raw_affiliation_string': 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'institution_ids': ['https://openalex.org/I4210094195']}, {'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021196395', 'display_name': 'Carlo Napolitano', 'orcid': 'https://orcid.org/0000-0002-7643-4628'}, 'institutions': [{'id': 'https://openalex.org/I4210094195', 'display_name': 'Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda', 'ror': 'https://ror.org/00htrxv69', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094195']}, {'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}, {'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}, {'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Carlo Napolitano', 'raw_affiliation_strings': ['Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'institution_ids': ['https://openalex.org/I4210094195']}, {'raw_affiliation_string': 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'institution_ids': ['https://openalex.org/I25217355', 'https://openalex.org/I4210105320']}, {'raw_affiliation_string': 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'institution_ids': ['https://openalex.org/I292310028']}, {'raw_affiliation_string': 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036259472', 'display_name': 'Natascia Tiso', 'orcid': 'https://orcid.org/0000-0002-5444-9853'}, 'institutions': [{'id': 'https://openalex.org/I4210094195', 'display_name': 'Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda', 'ror': 'https://ror.org/00htrxv69', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094195']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}, {'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}, {'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Natascia Tiso', 'raw_affiliation_strings': ['Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'institution_ids': ['https://openalex.org/I4210094195']}, {'raw_affiliation_string': 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'institution_ids': ['https://openalex.org/I292310028']}, {'raw_affiliation_string': 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'institution_ids': ['https://openalex.org/I25217355']}, {'raw_affiliation_string': 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'institution_ids': ['https://openalex.org/I25217355', 'https://openalex.org/I4210105320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010776107', 'display_name': 'Mirella Memmi', 'orcid': 'https://orcid.org/0000-0003-4006-5661'}, 'institutions': [{'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}, {'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210094195', 'display_name': 'Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda', 'ror': 'https://ror.org/00htrxv69', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094195']}, {'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mirella Memmi', 'raw_affiliation_strings': ['Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).'], 'affiliations': [{'raw_affiliation_string': 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'institution_ids': ['https://openalex.org/I4210105320', 'https://openalex.org/I25217355']}, {'raw_affiliation_string': 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'institution_ids': ['https://openalex.org/I292310028']}, {'raw_affiliation_string': 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'institution_ids': ['https://openalex.org/I4210094195']}, {'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049476692', 'display_name': 'Gabriele Vignati', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}, {'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210094195', 'display_name': 'Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda', 'ror': 'https://ror.org/00htrxv69', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094195']}, {'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gabriele Vignati', 'raw_affiliation_strings': ['Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).'], 'affiliations': [{'raw_affiliation_string': 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'institution_ids': ['https://openalex.org/I4210105320', 'https://openalex.org/I25217355']}, {'raw_affiliation_string': 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'institution_ids': ['https://openalex.org/I292310028']}, {'raw_affiliation_string': 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'institution_ids': ['https://openalex.org/I4210094195']}, {'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006513124', 'display_name': 'Raffaella Bloise', 'orcid': 'https://orcid.org/0000-0003-3485-9596'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}, {'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210094195', 'display_name': 'Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda', 'ror': 'https://ror.org/00htrxv69', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094195']}, {'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Raffaella Bloise', 'raw_affiliation_strings': ['Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).'], 'affiliations': [{'raw_affiliation_string': 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'institution_ids': ['https://openalex.org/I25217355', 'https://openalex.org/I4210105320']}, {'raw_affiliation_string': 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'institution_ids': ['https://openalex.org/I292310028']}, {'raw_affiliation_string': 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'institution_ids': ['https://openalex.org/I4210094195']}, {'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005342278', 'display_name': 'Vincenzo Sorrentino', 'orcid': 'https://orcid.org/0000-0002-8573-8631'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}, {'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}, {'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}, {'id': 'https://openalex.org/I4210094195', 'display_name': 'Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda', 'ror': 'https://ror.org/00htrxv69', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094195']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Vincenzo Sorrentino', 'raw_affiliation_strings': ['Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).'], 'affiliations': [{'raw_affiliation_string': 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'institution_ids': ['https://openalex.org/I25217355', 'https://openalex.org/I4210105320']}, {'raw_affiliation_string': 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'institution_ids': ['https://openalex.org/I292310028']}, {'raw_affiliation_string': 'Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'institution_ids': ['https://openalex.org/I4210094195']}, {'raw_affiliation_string': 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113594355', 'display_name': 'Gian Antonio Danieli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}, {'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}, {'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210094195', 'display_name': 'Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda', 'ror': 'https://ror.org/00htrxv69', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094195']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gian Antonio Danieli', 'raw_affiliation_strings': ['Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).'], 'affiliations': [{'raw_affiliation_string': 'From the Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy (S.G.P., C.N., M.M., R.B.); Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.); Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.); Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.); DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.); and the Molecular Medicine Section, Department of Neuroscience,...', 'institution_ids': ['https://openalex.org/I25217355', 'https://openalex.org/I4210105320']}, {'raw_affiliation_string': 'Laboratory of Human Genetics, Department of Biology, University of Padova, Padova, Italy (N.T., G.A.D.)', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'DIBIT, Scientific Institute San Raffaele, Milan, Italy (V.S.)', 'institution_ids': ['https://openalex.org/I292310028']}, {'raw_affiliation_string': 'the Molecular Medicine Section, Department of Neuroscience, University of Siena, Italy (V.S).', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Cardiology Department A De Gasperis, Niguarda Hospital, Milan, Italy (G.V.)', 'institution_ids': ['https://openalex.org/I4210094195']}, {'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Pavia, Italy (S.G.P.)', 'institution_ids': ['https://openalex.org/I25217355']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 33.095, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1360, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '103', 'issue': '2', 'first_page': '196', 'last_page': '200'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11217', 'display_name': 'Cardiac Arrhythmias and Treatments', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778178275', 'wikidata': 'https://www.wikidata.org/wiki/Q1649897', 'display_name': 'Catecholaminergic polymorphic ventricular tachycardia', 'level': 5, 'score': 0.9645406}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.86262345}, {'id': 'https://openalex.org/C113217602', 'wikidata': 'https://www.wikidata.org/wiki/Q416781', 'display_name': 'Ryanodine receptor', 'level': 3, 'score': 0.8410181}, {'id': 'https://openalex.org/C190712762', 'wikidata': 'https://www.wikidata.org/wiki/Q18031341', 'display_name': 'Ryanodine receptor 2', 'level': 4, 'score': 0.6598321}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.59045684}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.5815324}, {'id': 'https://openalex.org/C2776824294', 'wikidata': 'https://www.wikidata.org/wiki/Q18344428', 'display_name': 'Catecholaminergic', 'level': 3, 'score': 0.5477669}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.43940789}, {'id': 'https://openalex.org/C2780283014', 'wikidata': 'https://www.wikidata.org/wiki/Q209583', 'display_name': 'Tachycardia', 'level': 2, 'score': 0.43025255}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.37294537}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.24784073}, {'id': 'https://openalex.org/C2775894120', 'wikidata': 'https://www.wikidata.org/wiki/Q271663', 'display_name': 'Catecholamine', 'level': 2, 'score': 0.14991492}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.09123239}], 'mesh': [{'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019837', 'descriptor_name': 'Ryanodine Receptor Calcium Release Channel', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017180', 'descriptor_name': 'Tachycardia, Ventricular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002395', 'descriptor_name': 'Catecholamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010375', 'descriptor_name': 'Pedigree', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019837', 'descriptor_name': 'Ryanodine Receptor Calcium Release Channel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017180', 'descriptor_name': 'Tachycardia, Ventricular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.cir.103.2.196', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11208676', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.cir.103.2.196', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W12635643', 'https://openalex.org/W1792891338', 'https://openalex.org/W1802953485', 'https://openalex.org/W1967658895', 'https://openalex.org/W1985783132', 'https://openalex.org/W1986652655', 'https://openalex.org/W1991571518', 'https://openalex.org/W2008125074', 'https://openalex.org/W2013023765', 'https://openalex.org/W2031859242', 'https://openalex.org/W2047664621', 'https://openalex.org/W2050831484', 'https://openalex.org/W2084756418', 'https://openalex.org/W2095405649', 'https://openalex.org/W2129968803', 'https://openalex.org/W2131549396', 'https://openalex.org/W2140313980', 'https://openalex.org/W2144634347', 'https://openalex.org/W2150181869', 'https://openalex.org/W2153379369', 'https://openalex.org/W2224403790', 'https://openalex.org/W2226437153', 'https://openalex.org/W232265029', 'https://openalex.org/W2464511637'], 'related_works': ['https://openalex.org/W4392396544', 'https://openalex.org/W3137013278', 'https://openalex.org/W2791495462', 'https://openalex.org/W2790578500', 'https://openalex.org/W2685057422', 'https://openalex.org/W2420071309', 'https://openalex.org/W2160076218', 'https://openalex.org/W2053430609', 'https://openalex.org/W1989056964', 'https://openalex.org/W1965719501'], 'abstract_inverted_index': {'Background': [0], '—Catecholaminergic': [1], 'polymorphic': [2, 97, 238], 'ventricular': [3, 14, 31, 98, 239], 'tachycardia': [4, 15, 32, 99], 'is': [5, 232], 'a': [6, 52, 79, 202, 233], 'genetic': [7], 'arrhythmogenic': [8], 'disorder': [9], 'characterized': [10], 'by': [11, 146], 'stress-induced,': [12], 'bidirectional': [13], 'that': [16, 51, 156, 208], 'may': [17], 'degenerate': [18], 'into': [19], 'cardiac': [20, 72], 'arrest': [21], 'and': [22, 41, 89, 116, 193, 212], 'cause': [23], 'sudden': [24, 206], 'death.': [25], 'The': [26, 179], 'electrocardiographic': [27], 'pattern': [28], 'of': [29, 56, 64, 103, 128, 151, 169, 196, 219], 'this': [30, 83], 'closely': [33], 'resembles': [34], 'the': [35, 42, 62, 65, 70, 101, 129, 147, 152, 166, 170, 185, 217, 220], 'arrhythmias': [36], 'associated': [37], 'with': [38, 94, 204, 228], 'calcium': [39, 58], 'overload': [40], 'delayed': [43], 'afterdepolarizations': [44], 'observed': [45], 'during': [46], 'digitalis': [47], 'toxicity.': [48], 'We': [49], 'speculated': [50], 'genetically': [53, 84], 'determined': [54], 'abnormality': [55], 'intracellular': [57], 'handling': [59], 'might': [60], 'be': [61], 'substrate': [63], 'disease;': [66], 'therefore,': [67], 'we': [68], 'considered': [69], 'human': [71], 'ryanodine': [73], 'receptor': [74], 'gene': [75, 234], '(': [76], 'hRyR2': [77, 130, 231], ')': [78], 'likely': [80], 'candidate': [81], 'for': [82, 236], 'transmitted': [85], 'arrhythmic': [86], 'disorder.': [87], 'Methods': [88], 'Results': [90], '—Twelve': [91], 'patients': [92], 'presenting': [93], 'typical': [95], 'catecholaminergic': [96, 237], 'in': [100, 142, 184, 187, 194, 201, 216, 226], 'absence': [102], 'structural': [104], 'heart': [105], 'abnormalities': [106], 'were': [107, 140], 'identified.': [108], 'DNA': [109], 'was': [110, 121, 182], 'extracted': [111], 'from': [112], 'peripheral': [113], 'blood': [114], 'lymphocytes,': [115], 'single-strand': [117], 'conformation': [118], 'polymorphism': [119], 'analysis': [120, 150], 'performed': [122], 'on': [123], 'polymerase': [124], 'chain': [125], 'reaction–amplified': [126], 'exons': [127], 'gene.': [131], 'Four': [132], 'single': [133], 'nucleotide': [134], 'substitutions': [135], 'leading': [136], 'to': [137], 'missense': [138], 'mutations': [139], 'identified': [141, 183], '4': [143, 188], 'probands': [144, 158], 'affected': [145, 190], 'disease.': [148], 'Genetic': [149], 'asymptomatic': [153], 'parents': [154], 'revealed': [155], '3': [157, 197], 'carried': [159], 'de': [160], 'novo': [161], 'mutations.': [162], 'In': [163], '1': [164], 'case,': [165], 'identical': [167], 'twin': [168], 'proband': [171], 'died': [172], 'suddenly': [173], 'after': [174], 'having': [175], 'suffered': [176], 'syncopal': [177], 'episodes.': [178], 'fourth': [180], 'mutation': [181], 'proband,': [186], 'clinically': [189], 'family': [191, 199], 'members,': [192], 'none': [195], 'nonaffected': [198], 'members': [200], 'kindred': [203], '2': [205], 'deaths': [207], 'occurred': [209], 'at': [210], '16': [211], '14': [213], 'years,': [214], 'respectively,': [215], 'sisters': [218], 'proband.': [221], 'Conclusions': [222], '—We': [223], 'demonstrated': [224], 'that,': [225], 'agreement': [227], 'our': [229], 'hypothesis,': [230], 'responsible': [235], 'tachycardia.': [240]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2081524260', 'counts_by_year': [{'year': 2024, 'cited_by_count': 33}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 46}, {'year': 2021, 'cited_by_count': 48}, {'year': 2020, 'cited_by_count': 59}, {'year': 2019, 'cited_by_count': 47}, {'year': 2018, 'cited_by_count': 32}, {'year': 2017, 'cited_by_count': 63}, {'year': 2016, 'cited_by_count': 54}, {'year': 2015, 'cited_by_count': 46}, {'year': 2014, 'cited_by_count': 56}, {'year': 2013, 'cited_by_count': 78}, {'year': 2012, 'cited_by_count': 90}], 'updated_date': '2024-12-28T21:18:22.752442', 'created_date': '2016-06-24'}