Title: Defining Functional Redundancy of Epitope Data as Potential Antigenic Cross-Reactivity
Abstract: In assembling epitope datasets (e.g., to develop and benchmark epitope-prediction tools), sequence redundancy among epitopes must be considered to avoid misleading results that reflect overrepresentation of functionally similar epitopes. However, potentially useful data may be needlessly discarded by excluding epitopes that share an apparently high degree of sequence similarity, as even only a single-residue difference may manifest as extreme functional dissimilarity between epitopes. The present work thus introduces a reduced epitope count in order to account for functional redundancy of epitope data (FRED) within an epitope dataset (such that FRED is quantified as the difference between the total and reduced epitope counts); this can be used, for example, to characterize the dataset instead of excluding epitopes with apparently similar sequences from it, thereby maximizing the utilization of available epitope data.
Publication Year: 2013
Publication Date: 2013-09-22
Language: en
Type: article
Indexed In: ['crossref']
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