Publication Information

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2647, 2718, 2828, 2964, 2995, 3057, 3061, 3073, 3205, 3301, 3406, 3459, 3488, 3539, 3545, 3654, 3807, 3865, 4069], 'novel': [3, 171], 'human': [4, 76, 101, 122, 137, 172, 244, 269, 290, 305, 1183, 1253, 1616, 1641, 1676, 1695, 1732, 1877, 2418, 2496, 2499, 2571, 2623, 2651, 2657, 2671, 2759, 2813, 2987, 3070, 3250, 4139], 'gene': [5, 19, 39, 77, 86, 131, 173, 187, 207, 245, 254, 299, 849, 1149, 1693, 1706, 1741, 2967, 3805, 4105], 'whose': [6, 174], 'product': [7, 20, 175, 188, 1457, 1579], 'specifically': [8, 176, 1192, 2408, 4148], 'associates': [9, 177], 'with': [10, 28, 51, 69, 150, 178, 196, 219, 237, 318, 485, 1138, 1161, 1194, 1207, 1268, 1315, 1322, 1328, 1332, 1359, 1377, 1386, 1493, 1497, 1518, 1687, 1718, 1791, 1936, 1972, 1991, 2106, 2144, 2158, 2164, 2181, 2214, 2233, 2264, 2276, 2288, 2308, 2506, 2576, 2601, 2626, 2709, 2788, 2893, 2902, 3002, 3043, 3185, 3220, 3269, 3441, 4094, 4117, 4150, 4163], 'the': [11, 16, 129, 158, 163, 179, 184, 297, 326, 331, 353, 399, 407, 431, 446, 454, 460, 472, 490, 497, 508, 514, 526, 541, 546, 549, 567, 655, 658, 703, 716, 752, 764, 782, 822, 1097, 1105, 1132, 1148, 1157, 1162, 1173, 1182, 1186, 1195, 1202, 1224, 1231, 1264, 1269, 1288, 1300, 1305, 1309, 1316, 1323, 1333, 1347, 1350, 1354, 1360, 1380, 1409, 1416, 1421, 1430, 1436, 1441, 1467, 1473, 1498, 1512, 1530, 1558, 1581, 1596, 1614, 1649, 1653, 1658, 1668, 1701, 1712, 1738, 1766, 1774, 1784, 1842, 1865, 1869, 1876, 1887, 1894, 1905, 1918, 1929, 1932, 1937, 1947, 1979, 2014, 2021, 2029, 2039, 2071, 2074, 2077, 2107, 2112, 2248, 2251, 2271, 2338, 2349, 2353, 2380, 2383, 2396, 2399, 2424, 2441, 2460, 2465, 2477, 2507, 2543, 2554, 2558, 2565, 2602, 2613, 2627, 2667, 2730, 2755, 2773, 2781, 2845, 2877, 2880, 2883, 2887, 2895, 2905, 2911, 2914, 2939, 2946, 2986, 2990, 3015, 3022, 3078, 3173, 3196, 3216, 3226, 3254, 3266, 3281, 3309, 3355, 3363, 3387, 3402, 3410, 3416, 3428, 3446, 3453, 3464, 3470, 3482, 3497, 3502, 3505, 3523, 3611, 3614, 3659, 3672, 3708, 3720, 3738, 3778, 4053, 4061, 4088, 4104, 4113, 4118, 4129, 4138, 4142, 4151, 4158, 4180], 'negative': [12, 180], 'regulatory': [13, 181], 'domain': [14, 182, 1100, 1165, 1198, 1258, 1272, 1326, 1336, 1363, 1940, 2024, 2034, 2080, 2402, 2890, 4056, 4121, 4154], 'of': [15, 72, 104, 107, 109, 128, 157, 183, 240, 272, 275, 277, 296, 325, 356, 402, 405, 449, 457, 464, 476, 492, 500, 525, 535, 548, 569, 572, 585, 657, 702, 766, 786, 824, 843, 912, 1053, 1092, 1108, 1134, 1166, 1177, 1185, 1199, 1273, 1278, 1294, 1299, 1304, 1308, 1337, 1349, 1353, 1364, 1379, 1388, 1415, 1443, 1451, 1458, 1472, 1511, 1535, 1560, 1600, 1678, 1703, 1747, 1789, 1798, 1807, 1812, 1834, 1853, 1864, 1893, 1917, 1931, 1934, 1941, 1983, 2006, 2025, 2073, 2081, 2087, 2095, 2136, 2188, 2196, 2208, 2250, 2253, 2283, 2358, 2360, 2382, 2403, 2430, 2440, 2455, 2492, 2516, 2557, 2564, 2570, 2616, 2622, 2670, 2676, 2714, 2721, 2734, 2744, 2761, 2792, 2807, 2819, 2879, 2882, 2891, 2897, 2913, 2916, 2933, 2938, 2951, 2989, 2998, 3021, 3048, 3064, 3077, 3097, 3139, 3172, 3176, 3193, 3218, 3256, 3274, 3283, 3286, 3290, 3312, 3358, 3361, 3405, 3413, 3420, 3432, 3448, 3456, 3481, 3491, 3504, 3525, 3528, 3541, 3613, 3658, 3722, 3742, 3780, 3799, 3868, 4009, 4048, 4064, 4090, 4122, 4133, 4141, 4155], "Wilms'": [17, 185, 846, 3802], 'tumor': [18, 186, 847, 3803], '(WT1)': [21, 189], 'in': [22, 30, 64, 120, 190, 198, 232, 288, 421, 428, 441, 483, 507, 624, 653, 664, 763, 781, 821, 904, 1112, 1140, 1201, 1209, 1223, 1263, 1287, 1435, 1479, 1490, 1522, 1557, 1620, 1753, 1796, 1816, 1838, 1904, 1915, 1946, 2038, 2092, 2278, 2305, 2319, 2337, 2352, 2410, 2413, 2438, 2473, 2486, 2494, 2636, 2656, 2674, 2754, 2772, 2904, 2921, 2979, 3040, 3087, 3208, 3225, 3239, 3249, 3258, 3276, 3288, 3377, 3384, 3397, 3439, 3463, 3580, 3609, 3620, 3719, 3737, 3777, 3860, 4068, 4096, 4157, 4165, 4179], 'yeast': [24, 52, 80, 192, 220, 248, 610, 665, 717, 1158, 1187, 1203, 1265, 1289, 1539, 1622, 1650, 1704, 1739, 1824, 1870, 1948, 2040, 2384, 2906, 2962, 2980, 3054, 3068, 3184, 3194, 3242, 3259, 3566, 3621, 3673, 4114, 4143, 4159], 'two-hybrid': [25, 193, 1159, 1204, 1266, 1290, 1949, 2041, 2385, 2907, 4115, 4160], 'screen': [26, 194], 'and': [27, 32, 66, 115, 134, 147, 152, 162, 195, 200, 234, 283, 302, 315, 320, 330, 358, 427, 459, 502, 521, 635, 715, 784, 820, 1019, 1051, 1146, 1175, 1206, 1211, 1292, 1391, 1398, 1420, 1538, 1553, 1562, 1595, 1683, 1760, 1827, 1844, 1858, 1872, 1875, 1879, 1970, 2051, 2083, 2089, 2097, 2109, 2117, 2133, 2140, 2146, 2169, 2174, 2185, 2190, 2198, 2205, 2231, 2255, 2281, 2292, 2303, 2326, 2356, 2392, 2405, 2412, 2433, 2449, 2533, 2586, 2631, 2638, 2717, 2738, 2741, 2749, 2769, 2776, 2785, 2833, 2909, 2918, 2923, 2936, 2955, 2981, 3009, 3071, 3099, 3103, 3131, 3143, 3179, 3265, 3279, 3314, 3383, 3415, 3458, 3477, 3591, 3671, 3740, 3776, 3975, 4007, 4102, 4131, 4162, 4167], 'WT1': [29, 164, 197, 332, 1054, 1111, 1139, 1167, 1200, 1208, 1232, 1274, 1338, 1365, 1942, 2003, 2026, 2048, 2065, 2082, 2088, 2096, 2132, 2189, 2197, 2204, 2277, 2325, 2404, 2867, 2892, 2903, 2919, 3126, 3219, 3270, 4010, 4067, 4095, 4123, 4156, 4164], 'immunoprecipitation': [31, 199, 2354], 'glutathione': [33, 201, 1212, 1951, 4168], 'S-transferase': [34, 202, 1213, 1952, 4169], '(GST)': [35, 203, 1953], 'capture': [36, 204, 1954, 2020, 2047, 2055, 2390, 2925], 'assays.': [37, 205, 1214, 2926, 4170], 'The': [38, 75, 206, 243, 519, 1215, 1396, 1404, 1446, 1576, 1640, 1819, 1882, 2099, 2295, 2314, 2331, 2536, 2548, 2597, 2650, 2662, 2758, 2825, 2927, 3018, 3211, 3475, 4171], 'encodes': [40, 208, 850, 1484, 1609, 1672, 3806], '17-kDa': [42, 210], 'protein': [43, 58, 211, 226, 338, 509, 573, 705, 855, 1137, 1234, 1351, 1456, 1486, 1502, 1519, 1546, 1578, 2017, 2148, 2389, 2847, 3238, 3294, 3465, 3529, 3661, 3811, 4093], 'that': [44, 81, 94, 142, 212, 249, 262, 310, 349, 435, 531, 552, 560, 621, 646, 668, 902, 1055, 1180, 1191, 1218, 1346, 1466, 1487, 1547, 1554, 1606, 1667, 1680, 1913, 1943, 1977, 2000, 2027, 2061, 2130, 2323, 2362, 2398, 2426, 2443, 2476, 2644, 2798, 2844, 2865, 2970, 2982, 3005, 3026, 3055, 3125, 3132, 3201, 3215, 3305, 3391, 3487, 3508, 3516, 3577, 3602, 3624, 3858, 4011, 4136, 4147, 4174], 'has': [45, 213, 341, 666, 756, 3297, 3622, 3712], '56%': [46, 214, 1525], 'amino': [47, 215, 1460, 1508, 1532, 1786, 1799, 1835, 1900, 2031, 2262, 2948, 2999], 'acid': [48, 216, 1501, 1509, 1533, 1787, 1800, 1836, 1901, 2032, 2949, 3000], 'sequence': [49, 217, 1510, 1534, 1788, 1801, 1862, 1907, 2950], 'identity': [50, 68, 218, 236, 1526, 1837, 2932, 3001], 'ubiquitin-conjugating': [53, 73, 221, 241, 424, 561, 579, 1188, 1540, 1809, 3380, 3517, 3535, 4144], 'enzyme': [54, 222, 409, 479, 1189, 1541, 2978, 3365, 3435, 4145], '(yUBC)': [55, 223], '9,': [56, 224], 'required': [59, 227, 538, 1549, 3094, 3494], 'for': [60, 228, 352, 511, 576, 1550, 1592, 1762, 2153, 2179, 2348, 3095, 3104, 3260, 3308, 3467, 3532], 'cell': [61, 229, 632, 674, 1551, 2707, 3088, 3128, 3197, 3227, 3262, 3588, 3630], 'cycle': [62, 230, 633, 3089, 3129, 3228, 3263, 3589], 'progression': [63, 231, 3130, 3192, 3264], 'yeast,': [65, 233, 3083], 'significant': [67, 235, 2931], 'other': [70, 238, 1792, 1808, 2461, 3003], 'subfamilies': [71, 239], 'enzymes.': [74, 242, 1603, 1794], 'fully': [78, 89, 246, 257, 1402, 1644, 2973, 3052, 3182], 'complements': [79, 247, 1700, 2961, 3183], 'have': [82, 96, 250, 264, 618, 708, 1155, 1690, 2452, 2984, 3006, 3028, 3204, 3574, 3664, 4111], 'temperature-sensitive': [84, 252, 1625, 1713, 2965, 3058, 3187], 'yUBC9': [85, 151, 253, 319, 1627, 1654, 1679, 3186], 'mutation': [87, 255, 1628], 'to': [88, 136, 256, 304, 391, 395, 438, 471, 539, 544, 566, 673, 760, 1144, 1320, 1648, 1967, 2019, 2046, 2054, 2123, 2150, 2176, 2246, 2422, 2459, 2541, 2726, 2795, 2822, 2900, 3014, 3051, 3069, 3123, 3189, 3243, 3347, 3351, 3394, 3427, 3495, 3500, 3522, 3629, 3716, 4100], 'restore': [90, 258], 'normal': [91, 259, 1646, 3191, 3261], 'growth,': [92, 260], 'indicating': [93, 261, 2797, 2969], 'we': [95, 263, 1044, 1154, 1670, 2618, 2983, 3027, 3199, 4000, 4110], 'cloned': [97, 265, 2985, 3008], 'functionally': [99, 267, 1684, 2960], 'conserved': [100, 268, 591, 1686, 3024, 3237, 3547], '(h)': [102, 270, 1696], 'homolog': [103, 271, 1184, 1643, 1677, 2988, 4140], 'yUBC9.': [105, 273, 1688, 2956, 2991], 'Transcripts': [106, 274, 2429], 'hUBC9': [108, 130, 143, 276, 298, 311, 1790, 1935, 2101, 2199, 2254, 2257, 2273, 2316, 2328, 2333, 2364, 2406, 2456, 2478, 2493, 2509, 2566, 2604, 2645, 2663, 2799, 2808, 2917, 2971, 3181, 3202, 3221, 3233, 3275], '4.4': [110, 278], 'kilobases': [111, 279], '(kb),': [112, 280], '2.8': [113, 281], 'kb,': [114, 282, 2746, 2748], '1.3': [116, 284, 2434], 'kb': [117, 285, 1393, 2435, 2737, 2740, 2751, 2763], 'were': [118, 286, 1284, 1394, 1401, 1751, 1802, 1884, 1956, 1986, 2121, 2142, 2162, 2211, 2286, 2297, 2420, 2436, 2444, 2574, 2589, 2690, 2752], 'found': [119, 133, 287, 301], 'all': [121, 289, 1601, 2686], 'tissues': [123, 291, 2419, 2425, 2442, 2462], 'tested.': [124, 292], 'A': [125, 293, 1524, 2498, 2704], 'single': [126, 294, 2633], 'copy': [127, 295], 'was': [132, 300, 1261, 1375, 1476, 1516, 1527, 1618, 1716, 1944, 1960, 2103, 2244, 2258, 2274, 2317, 2334, 2346, 2504, 2539, 2599, 2653, 2724, 2764, 2770], 'localized': [135, 303, 2697], 'chromosome': [138, 306, 2672, 2767], '16p13.3.': [139, 307, 2824], 'conclude': [141, 309], 'retains': [144, 312, 2994], 'striking': [145, 313, 1832, 3062, 3174], 'structural': [146, 314], 'functional': [148, 316, 1611, 1854, 2974, 3065], 'conservation': [149, 317, 3066, 3175], 'suggest': [153, 321, 1217, 1345, 2843, 3200, 3214, 3271, 4173], 'possible': [155, 323], 'link': [156, 324], 'ubiquitin/proteosome': [159, 327], 'proteolytic': [160, 328, 528, 754, 3484, 3710], 'pathway': [161, 329, 348, 3304], 'transcriptional': [165, 333, 910, 1059, 1256, 3866, 4015], 'repressor': [166, 334, 911, 1099, 1106, 1164, 1197, 1271, 1335, 1362, 1939, 2033, 2079, 2401, 2868, 2889, 3867, 4055, 4062, 4120, 4153], 'system.': [167, 335, 660, 3616], 'INTRODUCTIONThe': [336, 3292], 'ubiquitin-dependent': [337, 527, 753, 3293, 3483, 3709], 'degradation': [339, 355, 397, 512, 765, 783, 1559, 3096, 3295, 3311, 3353, 3468, 3721, 3739], 'system': [340, 529, 707, 755, 1160, 1205, 1267, 3296, 3485, 3663, 3711, 4116, 4161], 'been': [342, 619, 709, 758, 3007, 3298, 3575, 3665, 3714], 'recognized': [343, 2372, 3299], 'as': [344, 629, 908, 917, 1058, 1168, 1275, 1424, 1426, 1694, 1962, 2036, 2111, 2546, 2975, 3145, 3147, 3300, 3585, 3864, 3873, 4014, 4124], 'complete': [346, 3302], 'enzymatic': [347, 3303], 'is': [350, 388, 468, 537, 558, 671, 1366, 1548, 1555, 1681, 1891, 1902, 1910, 2469, 2479, 2646, 2870, 2874, 2972, 3010, 3032, 3060, 3085, 3093, 3121, 3135, 3234, 3252, 3306, 3344, 3424, 3493, 3514, 3627], 'responsible': [351, 3307], 'selective': [354, 577, 3041, 3310, 3533], 'abnormal': [357, 3313], 'short-lived': [359, 3315], 'proteins': [360, 393, 551, 586, 1307, 2056, 2120, 2371, 3316, 3349, 3507, 3542], '(1Finley': [361, 3317], 'D.': [362, 960, 3318, 3916], 'Chau': [363, 736, 3319, 3692], 'V.': [364, 737, 3320, 3693], 'Annu.': [365, 377, 602, 3321, 3333, 3558], 'Rev.': [366, 378, 603, 3322, 3334, 3559], 'Cell': [367, 3323], 'Biol.': [368, 989, 1013, 1083, 3324, 3945, 3969, 4039], '1991;': [369, 728, 747, 3325, 3684, 3703], '7:': [370, 3326], '25-69Google': [371, 3327], 'Scholar,': [372, 685, 731, 802, 884, 1075, 3328, 3641, 3687, 3758, 3840, 4031], '2Hershko': [373, 3329], 'A.': [374, 376, 639, 739, 746, 871, 888, 970, 1004, 3166, 3330, 3332, 3595, 3695, 3702, 3827, 3844, 3926, 3960], 'Ciechanover': [375, 3331], 'Biochem.': [379, 3335], '1992;': [380, 605, 936, 991, 3336, 3561, 3892, 3947], '61:': [381, 3337], '761-807Google': [382, 3338], 'Scholar).': [383, 608, 750, 1042, 1088, 1575, 1639, 3116, 3170, 3339, 3564, 3706, 3998, 4044], 'In': [384, 609, 1142, 2011, 3082, 3117, 3340, 3565, 4098], 'this': [385, 844, 1151, 3118, 3133, 3341, 3800, 4107], 'process,': [386, 3342], 'ubiquitin': [387, 458, 467, 501, 669, 704, 1597, 3343, 3414, 3423, 3457, 3625, 3660], 'covalently': [389, 3345], 'linked': [390, 3346], 'target': [392, 3045, 3348], 'prior': [394, 3350], 'their': [396, 3352], 'through': [398, 555, 3195, 3354, 3511], 'combined': [400, 3356], 'action': [401, 3357], 'three': [403, 3359], 'classes': [404, 3360], 'proteins,': [406, 3362], 'ubiquitin-activating': [408, 3364], '(E1),': [410, 3366], '1The': [411, 3367], 'abbreviations': [412, 3368], 'used': [413, 1156, 2035, 2245, 2421, 2540, 2725, 3369, 4112], 'are:': [414, 3370], 'E1ubiquitin-activating': [415, 3371], 'enzymeE2ubiquitin-conjugating': [416, 3372], 'enzymeE3ubiquitin-protein': [417, 3373], 'ligasePAGEpolyacrylamide': [418, 3374], 'gel': [419, 2166, 3375], 'electrophoresisHAhemagglutininkbkilobase(s)Mbmegabase(s)FISHfluorescence': [420, 3376], 'situ': [422, 3378], 'hybridization.': [423, 3379], 'enzymes': [425, 563, 580, 648, 3381, 3519, 3536, 3604], '(E2),': [426, 3382], 'some': [429, 1811, 1851, 3385], 'cases,': [430, 3386], 'ubiquitin-protein': [432, 3388], 'ligases': [433, 3389], '(E3)': [434, 3390], 'are': [436, 553, 574, 582, 622, 1814, 2551, 3392, 3509, 3530, 3538, 3578], 'believed': [437, 3393], 'be': [439, 650, 1221, 3038, 3223, 3395, 3606, 4177], 'important': [440, 3039, 3075, 3122, 3224, 3272, 3284, 3396], 'substrate': [442, 3398], 'recognition.': [443, 3399], 'E1': [444, 3400], 'catalyzes': [445, 489, 3401, 3445], 'ATP-dependent': [447, 3403], 'formation': [448, 491, 1594, 3404, 3447], 'thioester': [451, 1593, 3407], 'bond': [452, 495, 3408, 3451], 'between': [453, 496, 1529, 1841, 2076, 2712, 2801, 2945, 3409, 3452], 'C-terminal': [455, 498, 2022, 2186, 2888, 3411, 3454], 'glycine': [456, 499, 3412, 3455], 'active': [461, 473, 597, 1582, 1675, 2941, 3417, 3429, 3553], 'site': [462, 474, 593, 598, 1419, 1583, 2942, 3418, 3430, 3549, 3554], 'cysteine': [463, 475, 599, 1584, 2943, 3419, 3431, 3555], 'E1.': [465, 3421], '"Activated"': [466, 3422], 'then': [469, 2654, 3425], 'transferred': [470, 2175, 3426], 'an': [477, 486, 493, 595, 1135, 2265, 2309, 2976, 3235, 3433, 3442, 3449, 3551, 4091], 'E2': [478, 647, 1602, 1793, 2977, 3434, 3603], 'which': [480, 570, 1813, 3436, 3526], 'itself,': [481, 3437], 'or': [482, 1331, 1727, 1737, 1770, 2218, 2583, 3438], 'conjunction': [484, 3440], 'E3': [487, 3443], 'protein,': [488, 1153, 1470, 1965, 3444, 4109], 'isopeptide': [494, 3450], 'lysine': [504, 3460], 'ϵ-amino': [505, 3461], 'group': [506, 3462], 'targeted': [510, 575, 3466, 3531], 'by': [513, 588, 1228, 1478, 1988, 2171, 2192, 2373, 2591, 2660, 2810, 3137, 3231, 3469, 3544, 4184], '20': [515, 2736, 2762, 3471], 'S': [516, 3472], 'proteosome': [517, 3473], 'complex.': [518, 3474], 'diversity': [520, 656, 3476, 3612], 'multiple': [522, 1861, 3478], 'protein-protein': [523, 3479], 'interactions': [524, 2094, 2252, 3042, 3268, 3480], 'suggests': [530, 3072, 3486], 'high': [533, 2996, 3489], 'degree': [534, 1833, 1852, 2997, 3490], 'regulation': [536, 1226, 3289, 3492, 4182], 'achieve': [540, 3496], 'specificity': [542, 1930, 2072, 2249, 2878, 2912, 3498], 'needed': [543, 3499], 'control': [545, 1719, 2012, 2058, 3501], 'fate': [547, 3503], 'different': [550, 616, 2417, 2484, 2487, 2495, 3506, 3572], 'degraded': [554, 3510], 'ubiquitination.': [556, 3512], 'It': [557, 3513], 'likely': [559, 3515], '(E2)': [562, 3518], 'may': [564, 649, 1220, 3037, 3203, 3222, 3520, 3605, 4176], 'contribute': [565, 3521], 'determination': [568, 3524], 'groups': [571, 3527], 'degradation.The': [578, 3534], '(E2s)': [581, 3537], 'family': [584, 3540], 'characterized': [587, 3543], 'highly': [590, 1685, 3023, 3074, 3546], 'catalytic': [592, 3548], 'containing': [594, 3550], 'invariant': [596, 2940, 3552], '(3Jentsch': [600, 3556], 'S.': [601, 679, 691, 745, 795, 808, 969, 1036, 1570, 1634, 1825, 3111, 3165, 3557, 3635, 3647, 3701, 3751, 3764, 3925, 3992], 'Genet.': [604, 3560], '26:': [606, 3562], '179-207Google': [607, 3563], 'Saccharomyces': [611, 3567], 'cerevisiae,': [612, 1826, 3568], 'at': [613, 1657, 1765, 1773, 1912, 2260, 2483, 2699, 3569], 'least': [614, 3570], '10': [615, 2568, 3571], 'E2s': [617, 3573], 'identified': [620, 1045, 2318, 2437, 2849, 3029, 3576, 4001], 'involved': [623, 1222, 1556, 3086, 3579, 4178], 'essential': [625, 672, 3581, 3628], 'cellular': [626, 700, 3582, 3656], 'processes': [627, 3583], 'such': [628, 916, 3584, 3872], 'DNA': [630, 2223, 2573, 2587, 2625, 3586], 'repair,': [631, 3587], 'control,': [634, 3590], 'stress': [636, 3592], 'responses': [637, 3593], '(4Ciechanover': [638, 3594], 'Cell.': [640, 776, 798, 815, 834, 880, 3596, 3732, 3754, 3771, 3790, 3836], '1994;': [641, 835, 1039, 3597, 3791, 3995], '79:': [642, 3598], '13-21Google': [643, 3599], 'Scholar),': [644, 696, 780, 819, 838, 939, 974, 994, 1018, 1130, 1251, 3600, 3652, 3736, 3775, 3794, 3895, 3930, 3950, 3974, 4086], 'suggesting': [645, 839, 1131, 1849, 2475, 2643, 3601, 3795, 4087], 'key': [651, 3607], 'players': [652, 3608], 'establishing': [654, 3610], 'ubiquitin-proteolytic': [659, 3615], 'Although': [661, 3617], 'genetic': [662, 3618], 'analysis': [663, 2563, 3619], 'revealed': [667, 1945, 3623], 'conjugation': [670, 3626], 'viability': [675, 3105, 3631], '(5Seufert': [676, 3632], 'W.': [677, 687, 890, 1566, 1630, 3107, 3633, 3643, 3846], 'Jentsch': [678, 690, 1569, 1633, 3110, 3634, 3646], 'EMBO': [680, 3636], 'J.': [681, 865, 988, 1012, 1066, 1082, 1123, 1244, 2857, 3637, 3821, 3944, 3968, 4022, 4038, 4079], '1990;': [682, 881, 898, 3638, 3837, 3854], '9:': [683, 3639], '543-550Google': [684, 3640], '6Seufert': [686, 3642], 'Futcher': [688, 1567, 1631, 3108, 3644], 'B.': [689, 1002, 1568, 1632, 3109, 3645, 3958], 'Nature.': [692, 727, 897, 1571, 1635, 3112, 3648, 3683, 3853], '1995;': [693, 799, 816, 1072, 1127, 1248, 1572, 1636, 2861, 3113, 3167, 3649, 3755, 3772, 4028, 4083], '373:': [694, 1573, 1637, 3114, 3650], '78-81Google': [695, 1574, 1638, 3115, 3651], 'only': [697, 3653], 'few': [699, 3655], 'targets': [701, 3657], 'ligase': [706, 3662], 'identified.': [710, 3666], 'These': [711, 1343, 2068, 3667], 'include': [712, 3668], 'cyclin': [713, 3141, 3148, 3669], 'B': [714, 3670], 'transcription': [718, 1225, 3674, 4181], 'factor': [719, 920, 942, 977, 997, 1022, 3675, 3876, 3898, 3933, 3953, 3978], 'MATa2': [720, 3676], '(7Glotzer': [721, 3677], 'M.': [722, 733, 769, 886, 1068, 1121, 1242, 2855, 3155, 3678, 3689, 3725, 3842, 4024, 4077], 'Murray': [723, 3679], 'A.W.': [724, 3680], 'Kirschner': [725, 3681], 'M.W.': [726, 3682], '349:': [729, 3685], '132-138Google': [730, 3686], '8Hochstrasser': [732, 3688], 'Ellison': [734, 3690], 'M.J.': [735, 3691], 'Varshavsky': [738, 3694], 'Proc.': [740, 964, 3160, 3696, 3920], 'Natl.': [741, 965, 3161, 3697, 3921], 'Acad.': [742, 966, 3162, 3698, 3922], 'Sci.': [743, 967, 3163, 3699, 3923], 'U.': [744, 968, 3164, 3700, 3924], '88:': [748, 3704], '4606-4610Google': [749, 3705], 'Recently,': [751, 3707], 'also': [757, 2243, 2929, 3213, 3713], 'shown': [759, 1815, 3715], 'actively': [761, 3717], 'participate': [762, 3718], 'p53': [767, 3723], '(9Scheffner': [768, 3724], 'Huibregtse': [770, 3726], 'J.M.': [771, 3727], 'Vierstra': [772, 3728], 'R.D.': [773, 3729], 'Howley': [774, 3730], 'P.M.': [775, 3731], '1993;': [777, 971, 1015, 1085, 3733, 3927, 3971, 4041], '75:': [778, 3734], '495-505Google': [779, 3735], 'processing': [785, 823, 3741, 3779], 'cystic': [787, 3743], 'fibrosis': [788, 3744], 'transmembrane': [789, 3745], 'conductance': [790, 3746], 'regulator': [791, 3747], '(10Ward': [792, 3748], 'C.L.': [793, 3749], 'Omura': [794, 3750], 'Kopito': [796, 3752], 'R.R.': [797, 3753], '83:': [800, 817, 3756, 3773], '121-127Google': [801, 3757], '11Jensen': [803, 3759], 'T.J.': [804, 3760], 'Loo': [805, 3761], 'M.A.': [806, 1000, 3762, 3956], 'Pind': [807, 3763], 'Williams': [809, 3765], 'D.B.': [810, 3766], 'Goldberg': [811, 830, 3767, 3786], 'A.L.': [812, 831, 3768, 3787], 'Riordan': [813, 3769], 'J.R.': [814, 3770], '129-135Google': [818, 3774], 'NF-κB': [825, 3781], '(12Palombella': [826, 3782], 'V.J.': [827, 3783], 'Rando': [828, 3784], 'O.J.': [829, 3785], 'Maniatis': [832, 3788], 'T.': [833, 859, 3151, 3153, 3159, 3789, 3815], '78:': [836, 3792], '773-785Google': [837, 3793], 'more': [840, 1437, 2789, 3796], 'widespread': [841, 3797], 'roles': [842, 3273, 3285, 3798], 'system.The': [845, 3801], 'suppressor': [848, 3804], 'zinc': [852, 1094, 3808, 4050], 'finger': [853, 1095, 3809, 4051], 'DNA-binding': [854, 1325, 2023, 3810], '(13Call': [856, 3812], 'K.M.': [857, 3813], 'Glaser': [858, 3814], 'Ito': [860, 3816], 'C.Y.': [861, 3817], 'Buckley': [862, 3818], 'A.J.': [863, 958, 3819, 3914], 'Pelletier': [864, 3820], 'Haber': [866, 3822], 'D.A.': [867, 956, 3823, 3912], 'Rose': [868, 3824], 'E.A.': [869, 3825], 'Kral': [870, 3826], 'Yeger': [872, 3828], 'H.': [873, 945, 3829, 3901], 'Lewis': [874, 3830], 'W.H.': [875, 3831], 'Jones': [876, 3832], 'C.': [877, 3833], 'Housman': [878, 3834], 'P.E.': [879, 3835], '60:': [882, 3838], '509-520Google': [883, 3839], '14Gessler': [885, 3841], 'Poustka': [887, 3843], 'Gavenee': [889, 3845], 'Neve': [891, 3847], 'R.L.': [892, 3848], 'Orkin': [893, 3849], 'S.H.': [894, 3850], 'Bruns': [895, 3851], 'G.A.P.': [896, 3852], '343:': [899, 3855], '774-778Google': [900, 3856], 'Scholar)': [901, 2864, 3857], 'functions': [903, 3859], 'transient': [905, 3861], 'transfection': [906, 3862], 'assays': [907, 1955, 3863], 'several': [913, 1839, 3869], 'growth-related': [914, 3870], 'genes': [915, 3871], 'insulin-like': [918, 940, 3874, 3896], 'growth': [919, 941, 976, 1021, 1552, 1647, 1746, 3875, 3897, 3932, 3977], 'II': [921, 3877], '(15Drummond': [922, 3878], 'I.R.': [923, 3879], 'Madden': [924, 981, 3880, 3937], 'S.L.': [925, 982, 3881, 3938], 'Rohwer-Nutter': [926, 3882], 'P.': [927, 3883], 'Bell': [928, 3884], 'G.I.': [929, 3885], 'Sukhatme': [930, 950, 1026, 3886, 3906, 3982], 'V.P.': [931, 951, 1027, 3887, 3907, 3983], 'Rauscher': [932, 952, 985, 1009, 1032, 3888, 3908, 3941, 3965, 3988], 'III,': [933, 953, 986, 1010, 1033, 3889, 3909, 3942, 3966, 3989], 'F.J.': [934, 954, 987, 1011, 1034, 3890, 3910, 3943, 3967, 3990], 'Science.': [935, 3891], '257:': [937, 3893], '674-678Google': [938, 3894], 'IR': [943, 3899], '(16Werner': [944, 3900], 'Re': [946, 3902], 'G.G.': [947, 3903], 'Drummond': [948, 3904], 'I.A.': [949, 3905], 'Sens': [955, 3911], 'Garvin': [957, 3913], 'Leroitth': [959, 3915], 'Roberts': [961, 1028, 3917, 3984], 'Jr.,': [962, 3918], 'C.T.': [963, 3919], '90:': [972, 3928], '5828-5832Google': [973, 3929], 'platelet-derived': [975, 3931], 'A-chain': [978, 3934], '(17Wang': [979, 3935], 'Z.Y.': [980, 1062, 1077, 3936, 4018, 4033], 'Deuel': [983, 1069, 1080, 1124, 1245, 2858, 3939, 4025, 4036, 4080], 'T.F.': [984, 1070, 1081, 1125, 1246, 2859, 3940, 4026, 4037, 4081], 'Chem.': [990, 1014, 1084, 3946, 3970, 4040], '268:': [992, 1016, 1086, 3948, 3972, 4042], '9172-9175Google': [993, 1087, 3949, 4043], 'colony': [995, 3951], 'stimulating': [996, 3952], '1': [998, 2722, 3954], '(18Harrington': [999, 3955], 'Konieck': [1001, 3957], 'Song': [1003, 3959], 'Xia': [1005, 3961], 'X.L.': [1006, 3962], 'Fredericks': [1007, 3963], 'W.J.': [1008, 3964], '21271-21275Google': [1017, 3973], 'transforming': [1020, 3976], 'β1': [1023, 3979], '(19Dey': [1024, 3980], 'B.R.': [1025, 3981], 'A.B.': [1029, 3985], 'Sporn': [1030, 3986], 'M.B.': [1031, 3987], 'Kim': [1035, 3991], 'Mol.': [1037, 3993], 'Endocrinol.': [1038, 3994], '8:': [1040, 3996], '595-602Google': [1041, 3997], 'Previously,': [1043, 3999], 'two': [1046, 1405, 1431, 1513, 4002], 'separate': [1047, 4003], 'domains': [1048, 1840, 3025, 3036, 4004], '(residues': [1049, 1339, 4005], '85-179': [1050, 4006], '250-266)': [1052, 4008], 'function': [1056, 4012], 'independently': [1057, 1091, 4013, 4047], 'repressors': [1060, 4016], '(20Wang': [1061, 4017], 'Qiu': [1063, 1078, 1118, 1239, 2852, 4019, 4034, 4074], 'Q.Q.': [1064, 1079, 4020, 4035], 'Huang': [1065, 1122, 1243, 2856, 4021, 4078], 'Gurrieri': [1067, 1120, 1241, 2854, 4023, 4076], 'Oncogene.': [1071, 1126, 1247, 2860, 4027, 4082], '10:': [1073, 1128, 1249, 2862, 4029, 4084], '415-422Google': [1074, 4030], '21Wang': [1076, 4032], 'When': [1089, 4045], 'expressed': [1090, 1619, 1961, 2110, 2131, 2363, 2472, 2481, 4046], 'its': [1093, 2261, 3246, 4049], 'domain,': [1096, 4052], 'proximal': [1098, 1163, 1196, 1270, 1361, 2790, 4054, 4119, 4152], '(amino': [1101, 4057], 'acids': [1102, 1461, 4058], '85-179)': [1103, 4059], 'relieved': [1104, 3136, 4060], 'activity': [1107, 1599, 2869, 4063], 'wild': [1109, 4065], 'type': [1110, 4066], 'dose-dependent': [1114, 4070], 'manner': [1115, 4071], '(22Wang': [1116, 1237, 2850, 4072], 'Z.-Y.': [1117, 1238, 2851, 4073], 'Q.-Q.': [1119, 1240, 2853, 4075], '1243-1247Google': [1129, 1250, 2863, 4085], 'presence': [1133, 4089], 'interactive': [1136, 1152, 1233, 2846, 4092, 4108], 'vivo.': [1141, 4097], 'order': [1143, 4099], 'identify': [1145, 1230, 2423, 4101], 'clone': [1147, 1453, 1608, 2959, 4103], 'encoding': [1150, 4106], '"bait."': [1169, 4125], 'here': [1172, 4128], 'isolation': [1174, 4130], 'characterization': [1176, 4132], 'cDNA': [1178, 1373, 1406, 1432, 1474, 1483, 1514, 1617, 1669, 1734, 2102, 2538, 2605, 2629, 2953, 2958, 3050, 4134], 'clones': [1179, 1282, 1296, 1312, 1358, 1385, 1407, 1433, 1475, 1515, 1537, 2954, 4135], 'encode': [1181, 4137], '(yUBC9)': [1190, 4146], 'interacts': [1193, 4149], 'co-immunoprecipitation': [1210, 2195, 2393, 2922, 4166], 'results': [1216, 2381, 3212, 4172], 'UBC9': [1219, 1612, 1642, 1699, 1705, 1733, 1740, 1843, 1857, 1867, 1871, 1878, 1959, 2652, 2966, 2993, 3084, 3092, 3257, 4175], 'mediated': [1227, 4183], 'WT1.RESULTSTo': [1229], 'previously': [1235, 2848], 'described': [1236], 'placental': [1254, 1372], 'cDNA/Gal4': [1255], 'activation': [1257], 'fusion': [1259, 2016, 2114, 2119, 2388], 'library': [1260, 1374], 'screened': [1262, 1283], 'bait.': [1276], 'Eleven': [1277], '2': [1279, 1771, 2514], '×': [1280], '106': [1281], 'strongly': [1285, 1314, 2394, 2842], 'positive': [1286, 1311, 1357, 1381], 'screen,': [1291], 'seven': [1293], 'these': [1295, 1748, 3035], 'encoded': [1297, 1306, 1469], 'portions': [1298, 2187], 'same': [1301, 2339, 2544], 'protein.': [1302, 2115], 'Each': [1303, 1482, 2511], '7': [1310, 1355], 'interacted': [1313], 'bait': [1317, 2037], 'but': [1318, 2482, 2778, 2885, 3034], 'failed': [1319, 2018, 2045, 2053], 'interact': [1321, 2407, 2901], 'LexA': [1324], 'alone,': [1327], 'lamin': [1329, 2898], 'C,': [1330], 'second': [1334], '250-260)': [1340], '(Table': [1341], 'I).': [1342], 'data': [1344, 2069, 2841, 2928], 'interaction': [1348, 1933, 2075, 2086, 2881, 2915, 3217], 'products': [1352, 1503], 'related': [1356, 3013], 'specific.To': [1367], 'obtain': [1368], 'full-length': [1369, 1980, 2100], 'cDNAs,': [1370], 'probed': [1376, 2232, 2505, 2600, 2620], 'one': [1378], 'clones.': [1382], 'Eight': [1383], 'independent': [1384], 'inserts': [1387], '0.6,': [1389], '1.1,': [1390], '1.8': [1392], 'isolated.': [1395], '1.8-kb': [1397], '1.1-kb': [1399, 1615, 2508, 2603, 2628], 'cDNAs': [1400, 1468], 'sequenced.': [1403], 'share': [1408], 'initial': [1410], '15': [1411], 'base': [1412], 'pairs': [1413], 'upstream': [1414], 'translation': [1417], 'start': [1418], 'entire': [1422], 'coding': [1423], 'well': [1425, 3146], '3′-untranslated': [1427], 'regions.': [1428], 'However,': [1429], 'differ': [1434], '5′-untranslated': [1438], 'regions,': [1439], 'presumably': [1440], 'result': [1442, 1665], 'alternative': [1444], 'splicing.': [1445], 'longest': [1447], 'open': [1448], 'reading': [1449], 'frame': [1450], 'each': [1452, 1471, 2439], 'predicts': [1454], '157': [1459], '(Fig.': [1462, 1662, 1847, 2009, 2049, 2066, 2329, 2376, 2446, 2641, 2702], '1A).': [1463], 'To': [1464, 1604, 1744], 'establish': [1465, 1605, 1928, 2247], 'tested': [1477], 'vitro': [1480, 2093], 'transcription/translation.': [1481], 'migrated': [1488], 'identically': [1489], 'SDS-polyacrylamide': [1491, 2300], 'gels': [1492], 'mobility': [1495], 'consistent': [1496], 'predicted': [1499, 1507, 1531, 1577, 1785, 2947], '157-amino': [1500], '(data': [1504, 2802], 'not': [1505, 2063, 2335, 2369, 2803, 2886], 'shown).The': [1506], 'compared': [1517, 1783], 'sequences': [1520, 1883], 'deposited': [1521], 'GenBank™.': [1523], 'established': [1528, 1803], 'our': [1536, 1607, 1692, 2952, 3049], '9': [1542], '(yUBC9),': [1543], 'nuclear': [1545], 'S-': [1561, 3098], 'M-phase': [1563], 'cyclins': [1564, 3102], '(6Seufert': [1565, 1629, 3106], 'contains': [1580], 'residue': [1585, 2944], '(residue': [1586], '93': [1587], 'boxed,': [1588], 'Fig.': [1589, 1817], '1B)': [1590], 'necessary': [1591], 'conjugating': [1598], 'homolog,': [1613], 'carrying': [1623, 1652, 1711, 2963], '(ts)': [1626], 'restored': [1645], 'strain': [1651, 1709], 'ts': [1655], 'mutant': [1656, 3059], 'otherwise': [1659], 'nonpermissive': [1660], 'temperature': [1661, 1768, 1776], '2).': [1663], 'This': [1664, 2872], 'indicates': [1666], 'isolated': [1671], 'biologically': [1674], 'structurally': [1682], 'designated': [1691], 'UBC9.Fig.': [1697], '2Human': [1698], 'loss': [1702], 'function.': [1707], 'Yeast': [1708, 3091], 'W9432': [1710], 'ubc9-1': [1714], 'allele': [1715], 'transformed': [1717], 'vectors': [1720], '(row': [1721, 1735, 1742], '1,': [1722], 'p416GAL1;': [1723], 'row': [1724], '4,': [1725], 'pSE936)': [1726], 'constructs': [1728], 'expressing': [1729, 2203], 'either': [1730, 2215], '2)': [1736], '3).': [1743], 'compare': [1745], 'strains,': [1749], 'cells': [1750, 1976, 2008, 2060, 2129, 2202, 2210, 2285, 2322, 2361, 3251, 3278], 'spotted': [1752], 'dilution': [1755], 'series': [1756], 'on': [1757, 2227, 2299, 2553, 2593, 2666, 2685, 2692, 2766, 2812], 'galactose-containing': [1758], 'plates': [1759], 'incubated': [1761, 1971, 2143], '3.5': [1763], 'days': [1764, 1772], 'permissive': [1767], '(23°C)': [1769], 'restrictive': [1775], '(34°C).View': [1777], 'Large': [1778, 1922, 2238, 2607, 2836], 'Image': [1779, 1923, 2239, 2608, 2837], 'Figure': [1780, 1924, 2240, 2609, 2838], 'ViewerDownload': [1781, 1925, 2241, 2610, 2839], '(PPT)We': [1782], 'Identification': [1795], 'regions': [1797], 'within': [1804], 'number': [1806], 'enzymes,': [1810], '3.': [1818], 'UBCs': [1820, 3004, 3031], 'from': [1821, 1974, 2004, 2057, 2127, 2200, 2321, 2416, 2519, 2780, 3067, 3241], 'human,': [1822], 'pea,': [1823], 'Arabidopsis': [1828, 1866], 'thaliana': [1829], 'retain': [1830], 'UBC4': [1845, 1873, 1880, 3016], 'families': [1846], '3),': [1848], 'perhaps': [1850], 'overlap': [1855], 'among': [1856, 3030], 'UBC4.Fig.': [1859], '3A': [1860], 'alignment': [1863], 'sequence,': [1868], 'sequences,': [1874], 'sequences.': [1881], 'aligned': [1885, 1920], 'using': [1886], 'PILEUP': [1888, 1890], 'algorithm.': [1889], 'part': [1892], 'Wisconsin': [1895], 'Sequence': [1896], 'Analysis': [1897], 'Package.': [1898], 'An': [1899], 'placed': [1903], 'consensus': [1906], 'if': [1908], 'it': [1909, 3120], 'located': [1911, 2691], 'position': [1914], 'four': [1916], 'five': [1919], 'sequences.View': [1921], '(PPT)To': [1926, 2611], 'further': [1927, 2727], 'N-terminal': [1938, 2030, 2078, 2400, 2884], 'screening,': [1950, 2386], 'used.': [1957], 'Human': [1958, 2992], 'GST-fusion': [1964, 2147], 'coupled': [1966], 'glutathione-Sepharose': [1968, 2124], 'beads,': [1969], 'extracts': [1973, 2282], '293': [1975, 2007, 2059, 2128, 2201, 2209, 2279], 'express': [1978, 2064], '(or': [1981], 'fragments)': [1982], 'WT1.': [1984, 2256, 4185], 'Eluates': [1985], 'analyzed': [1987, 2304], 'Western': [1989, 2306], 'blots': [1990, 2307, 2415, 2621], 'rabbit': [1993], 'anti-WT1': [1994, 2216, 2289, 2350], 'polyclonal': [1995, 2290, 2343], 'antisera.': [1996], 'Repeated': [1997], 'experiments': [1998], 'demonstrated': [1999, 2920], 'GST-hUBC9': [2001, 2015, 2052, 2113, 2118], '"captures"': [2002], 'lysates': [2005, 2320, 2340, 2359], '4A).': [2010, 2067], 'experiments,': [2013], 'lacks': [2028], 'screening.': [2042], 'GST': [2043, 2108, 2116, 2145, 2387, 2924], 'alone': [2044, 2365], '4A),': [2050], 'did': [2062, 2368], 'support': [2070, 2395], 'hUBC9.Fig.': [2084], '4The': [2085], 'hUBC9.': [2090, 2098, 2428, 2871], 'A,': [2091], 'fused': [2104, 2259], 'in-frame': [2105], 'bound': [2122, 2149], 'beads.': [2125], 'Extracts': [2126, 2207], 'deletion': [2134], 'mutants': [2135], 'WT1,': [2137], 'WT1Δ1-84,': [2138], 'WT1Δ297-429,': [2139], 'WT1Δ1-294,': [2141], 'Sepharose': [2151], 'beads': [2152, 2161], '2-3': [2154], 'h.': [2155], 'Following': [2156], 'washing': [2157], 'lysis': [2159], 'buffer,': [2160], 'eluted': [2163], 'SDS': [2165], 'loading': [2167], 'buffer': [2168], 'separated': [2170, 2226, 2298, 2590], '15%': [2172, 2228], 'SDS-PAGE': [2173], 'nitrocellulose': [2177], 'filters': [2178], 'immunoblotting': [2180], 'antibodies': [2182], 'against': [2183], 'N-': [2184], 'visualized': [2191], 'fluorography.': [2193], 'B,': [2194, 2560], 'HA-hUBC9.': [2206], 'first': [2212, 2619], 'immunoprecipitated': [2213, 2287], '(WTC-19)': [2217], 'nonspecific': [2220], 'antibody': [2221, 2375], '(anti-Gal4': [2222], 'binding': [2224], 'domain),': [2225], 'SDS-PAGE,': [2229], 'blotted,': [2230, 2302], 'anti-HA': [2234, 2374], 'tag': [2235], 'monoclonal': [2236, 2312], 'antibody.View': [2237], '(PPT)Co-immunoprecipitation': [2242], 'terminus': [2263], 'influenza': [2266], '(flu)': [2267], 'hemagglutinin': [2268], '(HA)': [2269], '"tag,"': [2270], 'flu-"tagged"': [2272], 'co-expressed': [2275, 2324], 'cells,': [2280], 'co-expressing': [2284], 'antisera': [2291, 2351], 'washed': [2293], 'extensively.': [2294], 'immunoprecipitates': [2296], 'gels,': [2301], 'anti': [2310], 'flu-tag': [2311], 'antibody.': [2313], 'flu-tagged': [2315, 2327, 2332], '4B).': [2330, 2377], 'observed': [2336, 2632, 2753], 'when': [2341], 'anti-Gal4': [2344], 'antiserum': [2345], 'substituted': [2347], 'step,': [2355], 'immunoprecipitate': [2357], '(without': [2366], 'WT1)': [2367], 'contain': [2370, 3056], 'Taken': [2378], 'together,': [2379], 'assay,': [2391], 'conclusion': [2397, 2873], 'both': [2409], 'vivo': [2411], 'vitro.Northern': [2414], 'expresses': [2427], '4.4,': [2431], '2.4,': [2432], 'examined': [2445], '5A).': [2447], 'Heart': [2448], 'smooth': [2450, 2528], 'muscle': [2451, 2529], 'higher': [2453], 'levels': [2454, 2485], 'transcript': [2457], 'relative': [2458], 'analyzed,': [2463], 'whereas': [2464], '2.4-kb': [2466], 'mRNA': [2467], 'isoform': [2468], 'relatively': [2470], 'less': [2471], 'kidney,': [2474], 'ubiquitously': [2480], 'tissues.Fig.': [2488], '5A,': [2489], 'Northern': [2490, 2501], 'blot': [2491, 2502, 2545, 2562, 2598], 'tissues.': [2497], 'tissue': [2500], '(Clontech)': [2503], 'cDNA.': [2510], 'lane': [2512], 'contained': [2513], 'μg': [2515, 2569], 'poly(A)+': [2517], 'RNA': [2518], 'heart': [2520], '(H),': [2521, 2578], 'brain': [2522], '(B),': [2523, 2585], 'placenta': [2524], '(Pl),': [2525], 'lung': [2526], '(L),': [2527], '(SM),': [2530], 'kidney': [2531], '(K),': [2532], 'pancreas': [2534], '(Pa).': [2535], 'β-actin': [2537], 'probe': [2542, 2664, 2809, 2821], 'control.': [2547], 'size': [2549], 'markers': [2550], 'indicated': [2552], 'left': [2555], 'side': [2556], 'blot.': [2559], 'Southern': [2561, 2756], 'gene.': [2567, 2649, 2731], 'genomic': [2572, 2624], 'digested': [2575], 'HindIII': [2577], 'EcoRI': [2579], '(E),': [2580], 'BglII': [2581, 2637], '(Bg),': [2582], 'BamHI': [2584, 2639], 'fragments': [2588], 'electrophoresis': [2592], '1%': [2594], 'agarose': [2595], 'gel.': [2596], 'probe.View': [2606], 'determine': [2612], 'chromosomal': [2614], 'locus': [2615], 'hUBC9,': [2617, 2894], 'fragment': [2630], 'hybridization': [2634, 2818], 'bands': [2635, 2733, 2743], 'digests': [2640], '5B),': [2642], 'single-copy': [2648], 'mapped': [2655], 'metaphase': [2658, 2678, 2814], 'chromosomes': [2659], 'FISH.': [2661], 'hybridized': [2665], 'short': [2668], 'arm': [2669], '16': [2673, 2768], '22': [2675], '26': [2677], 'spreads': [2679], 'examined.': [2680], 'Among': [2681], '94': [2682], 'fluorescent': [2683], 'signals': [2684, 2696], 'chromosomes,': [2687], '55': [2688], '(58.5%)': [2689], 'band': [2693, 2760], '16p13.': [2694], 'Most': [2695], 'distally': [2698], 'subband': [2700, 2823], '16p13.3': [2701], '6).': [2703], 'mouse/human': [2705], 'somatic': [2706], 'panel': [2708], 'average': [2710], 'distance': [2711], 'breakpoints': [2713, 2791], '1.2': [2715], 'Mb': [2716, 2723], 'potential': [2719, 3019], 'resolution': [2720], 'fine': [2728], 'map': [2729], 'Major': [2732], 'approximately': [2735], '8.5': [2739], 'mouse': [2742], '9.5': [2745], '6': [2747], '3.2': [2750], 'blots.': [2757], 'present': [2765, 2771], 'hybrids': [2774, 2782, 2787], 'CY189': [2775], 'CY193': [2777, 2794], 'absent': [2779], 'CY14,': [2783], 'CY192,': [2784], 'additional': [2786], 'CY200,': [2793], 'CY189,': [2796], 'maps': [2800], 'shown).Fig.': [2804], '6Chromosomal': [2805], 'localization': [2806], 'FISH': [2811], 'chromosomes.': [2815], 'Note': [2816], 'specific': [2817, 3044, 3267], 'fluorescein-labeled': [2820], 'photograph': [2826], 'represents': [2827], 'computer-enhanced,': [2829], 'merged': [2830], 'image': [2831], '(arrow),': [2832], 'diamidino-2-phenylindole-stained': [2834], 'chromosomes.View': [2835], '(PPT)DISCUSSIONThe': [2840], 'modulates': [2866], 'based': [2875], 'upon': [2876, 2910], 'failure': [2896], 'C': [2899], 'system,': [2908], 'indicate': [2930], 'primary': [2934, 3177], 'structure': [2935, 3178], 'retention': [2937], 'Our': [2957], 'mutant,': [2968], 'most': [3011], 'closely': [3012], 'family.': [3017], 'importance': [3020], 'unclear,': [3033], 'proteins.The': [3046], 'ability': [3047], 'rescue': [3053], 'example': [3063], 'role': [3076, 3207, 3248], 'UBC9s': [3079], 'throughout': [3080], 'evolution.': [3081], 'progression.': [3090], 'M-': [3100], 'phase': [3101], 'context,': [3119], 'note': [3124], 'blocks': [3127], 'block': [3134, 3229], 'expression': [3138], 'exogenous': [3140], 'E': [3142], 'CDK2': [3144], 'D1/CDK4': [3149], '(27Kudoh': [3150], 'Ishidate': [3152], 'Moriyama': [3154], 'Toyoshima': [3156], 'K.': [3157], 'Akiyama': [3158], '92:': [3168], '4517-4521Google': [3169], 'Because': [3171], 'because': [3180], 'mutations': [3188], 'allow': [3190], 'cycle,': [3198], 'similar': [3206], 'eukaryotic': [3209], 'cells.': [3210], 'imposed': [3230], 'WT1.Human': [3232], 'extraordinarily': [3236], 'evolution': [3240], 'man.': [3244], 'Whereas': [3245], 'precise': [3247], 'unknown,': [3253], 'requirement': [3255], 'mammalian': [3277], 'raise': [3280], 'possibility': [3282], 'ubiquitination': [3287], 'transcription.': [3291]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2081469183', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}], 'updated_date': '2025-01-12T20:11:56.370902', 'created_date': '2016-06-24'}