Publication Information

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'abstract_inverted_index': {'Catabolite': [0, 220, 440], 'repression': [1, 217, 221, 437, 441, 4490], 'of': [2, 5, 73, 82, 85, 103, 110, 114, 118, 130, 139, 166, 170, 187, 192, 203, 209, 222, 225, 293, 302, 305, 323, 330, 334, 338, 350, 359, 386, 390, 407, 412, 423, 429, 454, 492, 495, 504, 524, 618, 622, 678, 721, 739, 845, 886, 893, 928, 1043, 1053, 1061, 1063, 1080, 1082, 1085, 1104, 1119, 1176, 1221, 1224, 1238, 1257, 1269, 1294, 1313, 1319, 1399, 1485, 1558, 1570, 1703, 1768, 1782, 1808, 1825, 1839, 1872, 1893, 1918, 1934, 1964, 2016, 2056, 2068, 2080, 2140, 2144, 2192, 2219, 2224, 2262, 2277, 2286, 2312, 2323, 2335, 2337, 2347, 2385, 2399, 2402, 2425, 2428, 2433, 2450, 2483, 2499, 2513, 2530, 2538, 2596, 2644, 2653, 2699, 2707, 2739, 2760, 2765, 2868, 2895, 2989, 2996, 2999, 3024, 3029, 3052, 3179, 3191, 3201, 3238, 3280, 3300, 3302, 3310, 3329, 3502, 3606, 3648, 3661, 3724, 3748, 3756, 3782, 3789, 3818, 3821, 3841, 3875, 3885, 3888, 3912, 3938, 3942, 3946, 3974, 4021, 4024, 4063, 4086, 4099, 4102, 4125, 4132, 4173, 4202, 4229, 4318, 4410, 4433, 4441, 4449, 4452, 4457, 4478, 4484, 4491, 4511, 4521, 4536, 4542, 4550, 4559, 4564, 4573, 4580, 4597, 4621, 4734, 4788, 4818, 4833, 4843, 4853, 4873, 4918, 4962, 4972, 4975, 5043, 5080, 5103, 5125, 5134], 'a': [3, 30, 59, 88, 119, 124, 142, 176, 223, 250, 279, 308, 339, 344, 362, 396, 485, 596, 616, 656, 941, 1030, 1044, 1083, 1108, 1236, 1258, 1334, 1606, 1619, 1765, 1776, 1861, 1938, 1952, 2045, 2049, 2069, 2158, 2172, 2181, 2204, 2362, 2371, 2458, 2474, 2545, 2594, 2654, 2832, 2893, 2972, 3135, 3192, 3330, 3485, 3500, 3603, 3677, 3715, 3740, 3754, 3787, 3886, 3932, 4004, 4019, 4031, 4174, 4205, 4475, 4498, 4626, 4671, 4827, 4848, 4871, 4905, 4926, 5020, 5086], 'number': [4, 224, 1084, 4872], 'catabolic': [6, 226, 497, 756, 1086, 4458], 'operons': [7, 227, 935], 'in': [8, 218, 228, 438, 480, 499, 513, 592, 670, 674, 743, 750, 758, 783, 842, 890, 1035, 1050, 1074, 1173, 1291, 1387, 1492, 1542, 1644, 1670, 1847, 1898, 1915, 1925, 2010, 2053, 2074, 2157, 2161, 2175, 2184, 2198, 2207, 2221, 2259, 2303, 2316, 2344, 2355, 2396, 2430, 2464, 2544, 2567, 2590, 2716, 2762, 2949, 3104, 3121, 3176, 3226, 3234, 3472, 3488, 3518, 3742, 3776, 3792, 3809, 3866, 3878, 3899, 3914, 3984, 4006, 4033, 4041, 4060, 4092, 4108, 4138, 4189, 4218, 4307, 4435, 4443, 4508, 4526, 4533, 4588, 4629, 4736, 4755, 4765, 4774, 4847, 4850, 4887, 4895, 4909, 4915, 4925, 4970, 5000, 5022, 5085, 5117], 'bacilli': [9, 229, 594], 'is': [10, 48, 105, 230, 268, 325, 551, 561, 615, 700, 705, 716, 785, 795, 878, 990, 1000, 1067, 1096, 1115, 1122, 1155, 1228, 1278, 2088, 2171, 2226, 2236, 2252, 2257, 2281, 2414, 2470, 2507, 2518, 2543, 2580, 2672, 2702, 2751, 2835, 3037, 3101, 3155, 3233, 3293, 3584, 3676, 3805, 3816, 3825, 3897, 4055, 4168, 4243, 4339, 4419, 4501, 4553, 4604, 4676, 4691, 4698, 4778, 4835, 4867, 4933, 4968, 5007, 5095], 'mediated': [11, 231], 'by': [12, 189, 232, 409, 790, 797, 839, 940, 1157, 1169, 1456, 1489, 1566, 1734, 1757, 1812, 1836, 1856, 1931, 1937, 2742, 2886, 2918, 3014, 3297, 3400, 3642, 3659, 3666, 3668, 3827, 4250, 4493, 4531, 4592, 4744, 4821, 4935], 'the': [13, 18, 23, 35, 69, 74, 92, 100, 111, 135, 157, 163, 167, 185, 193, 200, 207, 213, 233, 238, 243, 255, 289, 294, 312, 320, 331, 355, 377, 383, 387, 405, 413, 420, 427, 433, 490, 493, 502, 520, 525, 549, 608, 619, 662, 671, 675, 709, 719, 744, 819, 824, 843, 883, 887, 891, 929, 947, 952, 993, 1002, 1059, 1078, 1100, 1174, 1222, 1255, 1270, 1282, 1292, 1298, 1310, 1317, 1323, 1397, 1499, 1645, 1683, 1694, 1701, 1791, 1837, 1849, 1921, 1932, 1944, 2012, 2054, 2075, 2078, 2094, 2097, 2162, 2190, 2216, 2222, 2229, 2241, 2260, 2275, 2278, 2284, 2300, 2313, 2321, 2324, 2345, 2392, 2397, 2400, 2407, 2417, 2423, 2426, 2431, 2436, 2442, 2448, 2451, 2455, 2497, 2500, 2504, 2511, 2514, 2523, 2531, 2552, 2555, 2561, 2565, 2568, 2625, 2638, 2651, 2667, 2694, 2697, 2705, 2714, 2717, 2737, 2749, 2763, 2839, 2881, 2901, 2924, 2966, 2986, 2990, 3006, 3025, 3122, 3125, 3131, 3158, 3162, 3167, 3177, 3189, 3206, 3278, 3281, 3284, 3290, 3298, 3303, 3308, 3327, 3334, 3372, 3580, 3591, 3610, 3637, 3649, 3733, 3777, 3780, 3810, 3828, 3838, 3842, 3846, 3861, 3867, 3881, 3900, 3908, 3915, 3921, 3927, 3936, 3939, 3943, 3947, 3971, 3975, 3982, 3990, 4016, 4042, 4046, 4050, 4057, 4061, 4077, 4084, 4087, 4093, 4097, 4126, 4160, 4165, 4171, 4226, 4247, 4319, 4324, 4408, 4426, 4430, 4438, 4447, 4450, 4455, 4467, 4481, 4489, 4509, 4519, 4534, 4540, 4543, 4557, 4562, 4567, 4571, 4574, 4663, 4668, 4681, 4688, 4696, 4703, 4714, 4731, 4737, 4745, 4769, 4792, 4816, 4840, 4844, 4851, 4883, 4888, 4896, 4910, 4916, 4989, 5004, 5008, 5040, 5049, 5090, 5099, 5135], 'catabolite': [14, 216, 234, 436, 448, 526, 609, 1326], 'control': [15, 235, 610], 'protein': [16, 20, 236, 240, 611, 747, 1894, 2242, 3395, 4990], 'CcpA,': [17, 237, 1072, 1149, 1262, 1935, 2659, 3336, 3674, 4611, 4914], 'phosphocarrier': [19, 239, 746], 'HPr': [21, 46, 132, 147, 174, 241, 266, 352, 367, 394, 471, 748, 784, 846, 945, 1066, 1095, 1106, 1121, 1178, 1273, 1305, 1421, 1453, 1486, 1874, 1879, 1909, 1912, 2194, 2296, 2350, 2460, 2559, 2614, 2671, 2701, 2730, 2734, 2767, 2857, 3346, 3383, 3391, 3493, 3513, 3832, 3855, 3865, 4104, 4134, 4179, 4210, 4230, 4338, 4354, 4411, 4444, 4485, 4505, 4538, 4583, 4601, 4609, 4630, 4697, 4735, 5112], 'from': [22, 242, 1107, 1159, 1281, 1626, 2228, 2255, 2416, 2454, 2564, 2913, 3203, 3732, 4015, 4480, 4685, 4692, 4699, 4705, 4830, 5039], 'phosphoenolpyruvate-dependent': [24, 244, 710], 'sugar': [25, 210, 245, 430, 477, 711, 1320], 'transport': [26, 246, 712], 'system': [27, 247, 713, 4777], '(PTS),': [28, 248, 714], 'and': [29, 54, 91, 123, 183, 249, 274, 311, 343, 403, 573, 579, 595, 655, 823, 926, 933, 946, 1093, 1152, 1244, 1249, 1265, 1288, 1401, 1458, 1550, 1574, 1611, 1631, 1690, 1700, 1821, 1854, 1906, 2059, 2077, 2082, 2090, 2151, 2180, 2243, 2290, 2412, 2435, 2457, 2560, 2579, 2601, 2662, 2679, 2724, 2849, 2880, 2904, 2941, 2981, 2983, 3019, 3071, 3100, 3130, 3149, 3166, 3220, 3245, 3289, 3337, 3381, 3392, 3558, 3645, 3761, 3833, 3852, 3895, 3917, 3949, 3952, 3967, 3977, 3980, 3992, 4038, 4074, 4180, 4234, 4274, 4415, 4454, 4473, 4506, 4539, 4610, 4695, 4713, 4753, 4763, 4861, 4944, 4953, 4997, 5045, 5146, 5159, 5161], 'cis-acting': [31, 251], 'DNA': [32, 76, 121, 252, 296, 341, 659, 1154, 1248, 1277, 1290, 1539, 1579, 1623, 2017, 2046, 2086, 2149, 2163, 2220, 2231, 2280, 2287, 2291, 2339, 2403, 2429, 2456, 2542, 2600, 2723, 2727, 2740, 2854, 3126, 3163, 3248, 3285, 3612, 3734, 4512, 4530, 4819, 4852, 4884, 4897, 4924, 4947, 4995, 5024, 5100], 'sequence': [33, 253, 885, 2052, 2087, 2578, 2841, 3033, 3061, 3249, 3523, 4549, 4711, 4718, 4857], 'termed': [34, 254, 661], 'catabolite-responsive': [36, 256, 663], 'element': [37, 257, 664], '(cre).': [38, 258], 'We': [39, 259, 1232, 2309, 3483, 5128], 'present': [40, 260, 562, 4746], 'evidence': [41, 261, 702, 2745], 'that': [42, 47, 55, 78, 99, 134, 162, 179, 262, 267, 275, 298, 319, 354, 382, 399, 703, 794, 833, 1102, 2215, 2234, 2370, 2441, 2547, 2629, 2637, 2669, 2696, 2732, 2748, 2831, 2976, 3141, 3152, 3277, 3307, 3344, 3579, 3728, 3891, 3958, 3997, 4000, 4029, 4070, 4145, 4164, 4181, 4186, 4195, 4323, 4332, 4348, 4497, 4514, 4619, 4667, 4680, 4864, 4879, 4913, 5094], 'CcpA': [43, 89, 104, 140, 171, 197, 263, 309, 324, 360, 391, 417, 840, 877, 957, 1092, 1114, 1170, 1243, 1287, 1302, 1307, 1384, 1695, 1819, 1826, 2057, 2081, 2145, 2154, 2225, 2289, 2293, 2343, 2434, 2539, 2562, 2586, 2604, 2675, 2708, 2721, 2725, 2761, 2848, 2865, 3030, 3053, 3202, 3215, 3314, 3350, 3380, 3506, 3662, 4118, 4203, 4328, 4333, 4349, 4507, 4532, 4591, 4659, 4689, 4741, 4860, 4963, 5010], 'interacts': [44, 264, 3347], 'with': [45, 63, 145, 150, 265, 283, 365, 370, 1071, 1112, 1247, 1382, 1495, 1605, 1618, 1663, 1715, 1815, 1852, 1882, 1961, 2058, 2167, 2203, 2299, 2342, 2406, 2478, 2680, 2838, 2852, 3113, 3241, 3313, 3349, 3527, 3663, 3719, 4111, 4116, 4177, 4344, 4353, 4412, 4760, 4904, 4923, 4942, 5048, 5142, 5156], 'phosphorylated': [49, 269, 472, 789, 847, 4191, 4340, 4355], 'at': [50, 270, 473, 848, 1077, 1887, 2186, 2210, 2246, 2391, 2467, 3773, 3849, 3857, 4153, 4199, 4341, 4356, 4380, 4423, 4486, 4593, 4606], 'Ser46': [51, 271, 740, 782, 849, 1062, 4187, 4434, 4442, 4487, 4581, 4622], '(Ser(P)': [52, 272, 850], 'HPr)': [53, 273, 851, 3496], 'these': [56, 276, 1028, 2687, 3210, 3519, 4706], 'proteins': [57, 277, 3526, 4683, 4967, 4979], 'form': [58, 278, 4204], 'specific': [60, 143, 280, 363, 1145, 1165, 2711, 2752, 4499, 4994], 'ternary': [61, 281, 1146, 1259, 2408, 2437, 2452, 2501, 2515, 2639, 2655, 2833, 3195, 3331, 4544, 4575, 4794], 'complex': [62, 80, 144, 282, 300, 364, 1147, 1227, 1260, 1274, 1284, 2326, 2409, 2453, 2640, 2656, 2834, 3196, 3312, 3332, 3843, 3868, 4010, 4088, 4176, 4500, 4545, 4576, 4795, 4890, 5047], 'cre': [64, 75, 93, 284, 295, 313, 834, 884, 1153, 1266, 1276, 1289, 2051, 2338, 2577, 2599, 2663, 2684, 2754, 2840, 3182, 4529], 'DNA.': [65, 285, 1267, 2664], 'Titration': [66, 286], 'experiments': [67, 97, 287, 317, 830, 1591, 1602, 1647, 1659, 1948, 3172, 3211, 3240, 3342, 4115], 'following': [68, 288, 3766], 'circular': [70, 290], 'dichroism': [71, 291], 'signal': [72, 292, 2318, 2466, 2506, 2592], 'indicate': [77, 98, 297, 318, 2636, 3276], 'this': [79, 299, 1226, 3114, 3153, 3232, 3387, 3635, 3729, 4182, 4241, 4515, 4548, 4775, 4865, 4876, 5033, 5077, 5126], 'consists': [81, 301], 'two': [83, 303, 2642, 3853, 4216, 4682, 4707, 4732], 'molecules': [84, 304, 2643, 3856, 4982], 'Ser(P)': [86, 131, 146, 173, 306, 351, 366, 393, 469, 944, 1065, 1094, 1105, 1150, 1177, 1250, 1263, 1295, 1304, 1452, 1878, 1911, 2061, 2083, 2193, 2263, 2295, 2349, 2558, 2613, 2645, 2660, 2670, 2700, 2729, 2733, 2766, 2856, 3180, 3338, 3345, 3382, 3495, 3589, 3759, 3831, 3854, 3864, 4066, 4103, 4178, 4209, 4504, 4537, 4919, 5016, 5111], 'HPr,': [87, 204, 307, 424, 470, 1151, 1264, 1314, 2661, 3181, 3219, 3760, 4151, 4920, 5017], 'dimer,': [90, 310], 'sequence.': [94, 314, 4948], 'Limited': [95, 315, 1657, 3170], 'proteolysis': [96, 316, 1658, 1814, 2862, 2874, 2910, 2954, 3013, 3171, 3229, 3320, 3644, 5151], 'domain': [101, 122, 138, 169, 321, 342, 358, 389, 453, 3027, 3050, 3129, 3165, 3288, 3292, 3583, 3594, 3614, 3639, 3651, 4167, 5093], 'structure': [102, 322, 2015, 3028, 3051, 4787], 'similar': [106, 326, 3239, 3486, 4114, 4130, 4245, 4780, 4928], 'to': [107, 156, 198, 215, 327, 376, 418, 435, 501, 604, 708, 741, 752, 787, 880, 882, 937, 1058, 1069, 1241, 1275, 1308, 1325, 1547, 1553, 1587, 1628, 1705, 1764, 1827, 2005, 2008, 2043, 2327, 2378, 2473, 2510, 2521, 2541, 2550, 2610, 2676, 2683, 2703, 2753, 2846, 2873, 2908, 2922, 2971, 2985, 3035, 3063, 3186, 3199, 3228, 3236, 3318, 3321, 3376, 3525, 3609, 3672, 3837, 3880, 3902, 3907, 3923, 4045, 4083, 4122, 4246, 4428, 4488, 4555, 4585, 4678, 4781, 4825, 4882, 4929, 4964, 4991, 4993, 5018, 5031, 5082, 5097, 5107], 'other': [108, 328, 574, 598, 3064, 4965], 'members': [109, 329], 'LacI/GalR': [112, 332, 620], 'family': [113, 333, 621, 4790], 'helix-turn-helix': [115, 120, 335, 340, 3065, 3128, 3287, 3593, 3611, 4966, 4978], 'proteins,': [116, 336], 'comprised': [117, 337], 'C-terminal': [125, 137, 168, 345, 357, 388, 451, 2974, 3132, 3137, 3168, 3291, 3581, 3638, 3650, 4166, 5091], 'effector': [126, 346, 3582, 5092], 'domain.': [127, 347, 3169], 'NMR': [128, 158, 348, 378, 1947, 3401, 3655, 3762, 4161, 4615], 'titration': [129, 349, 2336, 2360, 2444, 2595, 4043, 4062, 4131], 'demonstrates': [133, 353], 'isolated': [136, 356, 3658, 3731], 'forms': [141, 175, 361, 395], 'but': [148, 368, 955], 'not': [149, 369, 956, 992, 1123, 2307, 2519, 2616, 2690, 3294, 3508, 3745, 3870, 4002, 4148, 4351, 4624], 'unphosphorylated': [151, 371, 1120, 4133, 4150, 4600], 'HPr.': [152, 372, 1064, 1251, 1296, 2062, 2084, 2264, 2646, 3339, 4067, 4436], 'Based': [153, 373, 1026, 3521], 'upon': [154, 374, 1027, 1099, 2320, 2937, 3522, 4009, 4421, 4986], 'perturbations': [155, 375], 'spectrum,': [159, 379, 2627], 'we': [160, 380, 2039, 2859, 3577, 4900], 'propose': [161, 381], 'binding': [164, 384, 1299, 2331, 2476, 2540, 2741, 3127, 3164, 3286, 3588, 3613, 3735, 4213, 4325, 4563, 4603, 4738, 4820, 4824, 4987, 5025, 5079, 5101], 'site': [165, 186, 385, 406, 1300, 4228, 4326, 4739], 'on': [172, 392, 607, 1303, 1594, 1775, 1860, 1951, 2624, 2965, 3032, 3058, 3379, 3512, 3714, 4049, 4208, 4466, 4561, 4582], 'contiguous': [177, 397, 4206], 'surface': [178, 398, 4207, 4214, 4242, 4248], 'encompasses': [180, 400, 4329], 'both': [181, 401, 3185, 4251], 'Ser(P)46': [182, 402], 'His15,': [184, 404, 4342], 'phosphorylation': [188, 201, 408, 421, 1060, 1311, 1457, 4422, 4431, 4440, 4483, 4579, 4620], 'enzyme': [190, 410, 2946, 4252, 4275, 4413, 4417], 'I': [191, 411, 828, 1161, 2757, 4253, 4418], 'PTS.': [194, 414, 4320], 'This': [195, 415, 2665, 3814, 3995, 4054, 4931], 'allows': [196, 416, 1306], 'recognize': [199, 419, 1309, 4662], 'state': [202, 422, 1312, 4432], 'effectively': [205, 425, 1315, 4445], 'linking': [206, 426, 1316], 'process': [208, 428, 1318], 'import': [211, 431, 720, 1321, 4451], 'via': [212, 432, 1322], 'PTS': [214, 434, 745, 1324, 3394, 4427], 'bacilli.': [219, 439], '(CR)': [442], '1The': [443], 'abbreviations': [444], 'used': [445, 1235, 1643, 2040, 2377, 2573, 3208, 4690], 'are:': [446], 'CR,': [447, 997], 'repression;': [449], 'CcpA-C,': [450, 3786], 'proteolytic': [452, 2997, 3109, 3604], 'CcpA;': [455], 'HSQC,': [456], 'heteronuclear': [457], 'single': [458, 2475], 'quantum': [459], 'coherence': [460], 'spectroscopy;': [461], 'MALDI-TOF,': [462], 'matrix-assisted': [463], 'laser': [464], 'desorption': [465], 'time-of-flight': [466], 'mass': [467, 1752, 1758, 1771, 2867, 2920, 2940, 2951, 2994, 3723, 5144], 'spectrometry;': [468], 'Ser46;': [474], 'PTS,': [475, 825], 'phosphoenolpyruvate': [476], 'phosphotransferase': [478], 'system.': [479, 4784, 5127], 'Escherichia': [481], 'coli': [482, 518], 'has': [483, 601, 667, 1038, 2002, 2631, 3054, 3599, 4670], 'provided': [484], 'general': [486, 1031, 4468], 'paradigm': [487], 'for': [488, 511, 584, 718, 754, 872, 996, 1033, 1301, 1561, 1829, 2422, 2496, 2528, 2554, 2583, 2674, 2709, 2720, 2944, 2953, 3005, 3116, 3209, 3386, 3587, 3602, 3654, 3863, 3931, 4096, 4170, 4327, 4470, 4528, 4570, 4590, 4740, 4983, 5132, 5140, 5149, 5153, 5162], 'understanding': [489], 'regulation': [491, 1076], 'synthesis': [494, 4456], 'various': [496, 722, 2065, 3774], 'enzymes': [498], 'response': [500], 'availability': [503, 1042], 'rapidly': [505, 1045], 'metabolizable': [506, 1046], 'carbon': [507, 1047], 'sources.': [508], 'The': [509, 1041, 1252, 1537, 1577, 1641, 1832, 1890, 1908, 2085, 2138, 2213, 2333, 2358, 2383, 2462, 2488, 2535, 2571, 2588, 2647, 2958, 3049, 3107, 3139, 3323, 3872, 4193, 4212, 4321, 4460, 4495, 4523, 4785, 4892, 4958], 'mechanism': [510, 550, 942, 995, 1004, 4469], 'CR': [512, 591, 704, 753, 822, 873, 927, 989, 1034, 4472], 'bacteria': [514, 1037, 1491], 'such': [515, 800, 3067, 3531], 'as': [516, 801, 1338, 1424, 1460, 1498, 1512, 1790, 2962, 3068, 3375, 3499, 3532, 3598, 3739, 4018, 4742, 4869, 5030], 'E.': [517, 1008, 1127, 1200, 1344, 2812, 3354, 4361, 4389], 'involves': [519], 'cyclic': [521, 556], 'AMP-dependent': [522], 'action': [523], 'gene': [527], 'activator': [528, 949], 'protein,': [529, 2991, 5014], 'CAP': [530, 559], '(1Postma': [531, 724], 'P.W.': [532, 725], 'Lengeler': [533, 726], 'J.W.': [534, 727, 3470, 4305], 'Jacobsen': [535, 728], 'G.R.': [536, 729], 'Microbiol.': [537, 690, 730, 861, 1135, 1188, 1371, 2110, 2782, 3091, 3362, 3703, 4369], 'Rev.': [538, 731], '1993;': [539, 732, 3437, 4292], '57:': [540, 733], '543-594Crossref': [541, 734], 'PubMed': [542, 634, 652, 694, 735, 779, 815, 865, 911, 923, 969, 985, 1021, 1139, 1192, 1213, 1357, 1375, 1414, 1449, 1478, 1532, 1745, 1802, 1995, 2033, 2114, 2133, 2786, 2806, 2825, 3083, 3095, 3259, 3271, 3366, 3417, 3440, 3460, 3572, 3630, 3689, 3707, 4269, 4295, 4373, 4404, 4653, 4808], 'Google': [543, 637, 653, 697, 736, 780, 816, 868, 912, 924, 970, 986, 1024, 1142, 1195, 1216, 1360, 1378, 1417, 1450, 1481, 1535, 1748, 1805, 1998, 2036, 2117, 2136, 2789, 2807, 2828, 3086, 3098, 3260, 3272, 3369, 3420, 3443, 3463, 3556, 3575, 3631, 3692, 3710, 4272, 4298, 4376, 4405, 4656, 4811, 5074], 'Scholar).': [544, 590, 698, 737, 781, 817, 869, 987, 1025, 1143, 1217, 1379, 1418, 1451, 1536, 1806, 1999, 2037, 2137, 3273, 3482, 3632, 4406, 4657, 5075], 'In': [545, 2843, 2890, 5076], 'Bacillus': [546, 571], 'subtilis,': [547], 'however,': [548, 3371, 4722], 'completely': [552, 3812], 'different,': [553, 2283], 'because': [554, 2503], 'no': [555, 2621, 3224], 'AMP': [557], 'or': [558, 673, 951, 1634, 1666, 1726, 1750, 1877, 1910, 2014, 2712, 2855, 2878, 3184, 3194, 3306, 3799, 4378], 'homologue': [560], '(2Chambliss': [563], 'G.H.': [564, 905, 917, 2122, 2800], 'Sonensheim': [565], 'A.L.': [566], 'Hoch': [567], 'J.A.': [568, 1794], 'Losick': [569], 'R.': [570, 1006, 1198, 1342, 2810, 3449, 4258, 4951, 4954], 'subtilis': [572, 680, 760, 931, 1420], 'Gram-positive': [575, 599, 1036], 'Bacteria:': [576], 'Biochemistry,': [577], 'Physiology': [578], 'Molecular': [580], 'Genetics.': [581], 'American': [582], 'Society': [583], 'Microbiology,': [585], 'Washington,': [586], 'D.': [587, 1367, 3699], 'C.1993:': [588], '213-219Google': [589], 'some': [593, 2237, 5001], 'few': [597], 'organisms': [600], 'been': [602, 668, 875, 1039, 2003, 2632, 3055, 3398, 3600], 'shown': [603, 832, 2302, 2354, 3003, 3038, 3102], 'be': [605, 788, 938, 2006, 2376, 2933, 3515, 3935, 4188, 5037], 'dependent': [606], 'A': [612, 1088, 1144, 3022, 4129, 4856, 5027], '(CcpA),': [613], 'which': [614, 666, 715, 1056, 2389, 2413, 3377, 3489, 3675, 4100, 4222, 4237, 4985], 'member': [617], 'regulators': [623, 3066], '(3Miwa': [624, 3073, 3679], 'Y.': [625, 629, 853, 855, 1180, 1182, 2774, 2776, 3074, 3078, 3680, 3684], 'Saikawa': [626, 3075, 3681], 'M.': [627, 773, 963, 1464, 3076, 3535, 3682, 4396, 5053], 'Fujita': [628, 3077, 3683], 'Microbiology.': [630, 3079, 3685], '1994;': [631, 691, 776, 2111, 3080, 3268, 3569, 3686, 4805], '140:': [632, 3081, 3687], '2567-2575Crossref': [633, 3082, 3688], 'Scopus': [635, 695, 866, 1022, 1140, 1193, 1214, 1358, 1376, 1415, 1479, 1533, 1746, 1803, 1996, 2034, 2115, 2134, 2787, 2826, 3084, 3096, 3367, 3418, 3441, 3461, 3554, 3573, 3690, 3708, 4270, 4296, 4374, 4654, 4809, 5072], '(59)': [636, 1804, 3085, 3691], 'Scholar,': [638, 913, 971, 1196, 1361, 2118, 2790, 2808, 3087, 3261, 3421, 3444, 3464, 3693, 4299], '4Weickert': [639], 'M.J.': [640, 806, 2120], 'Adhya': [641], 'S.': [642, 959, 961, 1980, 2128, 3089], 'J.': [643, 762, 764, 774, 804, 810, 859, 906, 918, 964, 975, 980, 1012, 1015, 1125, 1186, 1204, 1207, 1348, 1351, 1428, 1434, 1440, 1466, 1468, 1521, 1986, 1989, 2780, 2801, 2816, 2819, 3254, 3266, 3352, 3454, 3621, 4263, 4359, 4383, 4398, 4399, 4640], 'Biol.': [644, 1017, 1209, 1353, 1441, 1522, 2821, 3456, 3622, 4265], 'Chem.': [645, 1442, 1523, 3623], '1992;': [646, 1443, 2030, 3256], '267:': [647, 1444], '15869-15874Abstract': [648], 'Full': [649, 1446, 1527, 1529, 3627], 'Text': [650, 1447, 1528, 1530, 3628], 'PDF': [651, 1448, 1531, 3629], 'Scholar),': [654, 925, 2829, 3576, 3711], 'cis-active': [657], 'operator': [658], 'sequence,': [660], '(cre),': [665], 'identified': [669, 4743], 'promoter': [672], '5′': [676], 'region': [677, 3123, 3154], '29B.': [679], 'genes': [681, 757], '(5Hueck': [682, 2102], 'C.J.': [683, 1363, 2103, 3695], 'Hillen': [684, 1013, 1132, 1205, 1349, 1368, 2104, 2817, 3359, 3700, 4366, 4393], 'W.': [685, 1014, 1133, 1206, 1350, 1369, 2105, 2818, 3360, 3701, 4367, 4394], 'Saier': [686, 769, 807, 1437, 1469, 2106, 4390, 4641], 'Jr,': [687, 2107], 'M.H.': [688, 771, 809, 1439, 1471, 2108, 4392, 4643], 'Res.': [689, 2109, 3090], '145:': [692, 2112], '503-518Crossref': [693, 2113], '(173)': [696, 2116], 'There': [699], 'growing': [701, 1490], 'mechanistically': [706], 'linked': [707], 'responsible': [717, 3586, 4169], 'sugars': [723, 4453], 'Mutation': [738], 'Ala': [742], 'results': [749, 1049, 1158, 1253, 2156, 2197, 2266, 2334, 2635, 2649, 2688, 3237, 3275, 3325, 4162, 4346, 4461, 4747, 5084], 'resistance': [751, 3227], 'several': [755], 'B.': [759, 930, 1419, 4693, 4700, 4756, 4766], '(6Deutscher': [761], 'Reizer': [763, 1465, 4639], 'Fischer': [765], 'C.': [766], 'Galinier': [767, 856, 1009, 1183, 1201, 1345, 2777, 2813, 4386], 'A.': [768, 857, 977, 1010, 1184, 1202, 1346, 1365, 1988, 2129, 2778, 2814, 3408, 3697, 4387], 'Jr.,': [770, 808, 1438, 1470, 4391, 4642], 'Steinmetz': [772, 4395], 'Bacteriol.': [775, 811, 907, 919, 965, 981, 2802, 3255, 3267, 4400], '176:': [777, 3269], '3336-3344Crossref': [778], 'known': [786, 879, 3528], 'an': [791, 1595, 2141, 2329, 2380, 2386, 2479, 2844, 3720, 3953, 4586, 5118], 'ATP-dependent': [792], 'kinase': [793], 'activated': [796], 'glycolytic': [798, 1054], 'intermediates': [799], 'fructose-1,6-diphosphate': [802], '(7Reizer': [803], 'Novotny': [805], '1984;': [812], '160:': [813], '333-340Crossref': [814], 'Confirming': [818], 'link': [820], 'between': [821, 1091, 1261, 1286, 2240, 2557, 2658, 2978, 3124, 3146, 3161, 3283, 3333, 3390, 3830, 3893, 3989, 4503, 4730, 4837, 4859], 'recent': [826], 'DNase': [827, 1160, 2756], 'protection': [829, 1163, 1166, 2758, 2769, 3200], 'have': [831, 874, 1233, 3397, 4076, 4617], 'sequences': [835, 1168, 2772, 4996], 'are': [836, 1230, 2267, 2297, 2353, 2446, 2947, 3004, 3111, 3384, 3497, 3869, 3970, 4071, 4105, 4196, 4684, 4724, 4758, 4870, 4902], 'specifically': [837, 2678, 2836, 4661], 'protected': [838], 'only': [841, 994, 1171, 2508, 2575, 2584, 2770, 4725], 'presence': [844, 1175, 2055, 2076, 2139, 2191, 2223, 2261, 2346, 2432, 2764, 3178, 4535, 4917], '(8Fujita': [852, 1179, 2773], 'Miwa': [854, 1181, 2775], 'Deutscher': [858, 1011, 1185, 1203, 1347, 1433, 1467, 2779, 2815, 4397], 'Mol.': [860, 1016, 1134, 1187, 1208, 1352, 1370, 2781, 2820, 3361, 3455, 3702, 4264, 4368], '1995;': [862, 908, 982, 1136, 1189, 1372, 1992, 2783, 2803, 3363, 3457, 3551, 3704, 4266, 4370, 4650, 5069], '17:': [863, 1190, 2784], '953-960Crossref': [864, 1191, 2785], '(191)': [867, 1194, 2788], 'Other': [870, 2744, 4977], 'mechanisms': [871], 'established;': [876], 'bind': [881, 2677, 4149, 4992, 5012], 'amyE': [888], 'operon': [889], 'absence': [892, 1293, 2079, 4510], 'any': [894, 3301, 3311], 'corepressor': [895], '(9Kim': [896], 'J.H.': [897, 2792], 'Guvener': [898, 2793], 'Z.T.': [899, 2794], 'Cho': [900, 2795], 'J.Y.': [901, 2796], 'Chung': [902, 2797], 'K.-C.': [903, 2798], 'Chambliss': [904, 916, 2121, 2799], '177:': [909, 983, 2804], '5129-5134Crossref': [910, 2805], '10Voskuil': [914], 'M.I.': [915], '1996;': [920, 966, 1524, 1799, 3092, 4401], '178:': [921, 967, 4402], '7014-7015Crossref': [922], 'lev': [932], 'bgl': [934], 'appear': [936], 'regulated': [939], 'involving': [943, 1148], 'transcriptional': [948], 'LevR': [950], 'antiterminator': [953], 'LicT': [954], '(11Krüger': [958], 'Gertz': [960], 'Hecker': [962], '2637-2644Crossref': [968], '12Martin-Verstraete': [972], 'I.': [973], 'Stülke': [974], 'Klier': [976], 'Rapoport': [978], 'G.': [979, 1984, 3537, 5055], '6919-6927Crossref': [984], 'CcpA-mediated': [988, 4471], 'therefore': [991, 1234, 2581], 'although': [998, 2274], 'it': [999, 2251, 2517], 'probably': [1001, 4416, 4779], 'dominant': [1003], '(13Gösseringer': [1005, 1341], 'Küster': [1007, 1126, 1199, 1343, 2811, 3353, 4360, 4388], '1997;': [1018, 1210, 1354, 2822, 3414], '266:': [1019, 1211, 1355, 2823, 3570, 4806], '665-676Crossref': [1020, 1212, 1356, 2824], '(122)': [1023, 1215, 1359, 2827], 'data,': [1029], 'model': [1032], 'proposed.': [1040], 'source': [1048], 'elevated': [1051], 'levels': [1052], 'intermediates,': [1055], 'leads': [1057, 4584], 'proposed': [1068, 3026, 5096], 'interact': [1070, 4352, 4922], 'resulting': [1073, 4846], 'negative': [1075], 'level': [1079], 'transcription': [1081, 4492, 4999], 'genes.': [1087], 'direct': [1089], 'interaction': [1090, 2239, 2556, 2750, 2851, 3829, 4110, 4183, 4409, 4516, 4669], 'suggested': [1097, 1156], 'based': [1098, 2936, 3031, 3057], 'observation': [1101, 2214, 2384, 3140, 4322, 4496, 4541], 'elution': [1103, 1118, 1381], 'Ni2+-NTA': [1109, 1335], 'column': [1110, 1867, 3718], 'loaded': [1111], 'His-tagged': [1113], 'retarded,': [1116], 'whereas': [1117, 4027], '(14Deutscher': [1124, 3351, 4358], 'Bergstedt': [1128, 3355, 4362, 4384], 'U.': [1129, 2127, 3356, 4363, 4385], 'Charrier': [1130, 3357, 4364], 'V.': [1131, 3358, 3475, 4310, 4365], '15:': [1137, 3364, 4371], '1049-1053Crossref': [1138, 3365, 4372], '(304)': [1141, 3368, 4375], 'footprinting': [1162], 'studies;': [1164], 'ofcre': [1167], 'occurs': [1172, 2390, 3120, 3315], '13Gösseringer': [1197, 2809], 'To': [1218, 3633], 'date,': [1219], 'many': [1220], 'details': [1223], 'how': [1225, 5032], 'formed': [1229, 1285, 2657, 2837, 4502], 'unclear.': [1231], 'variety': [1237], 'biophysical': [1239], 'methods': [1240], 'characterize': [1242, 2847], 'its': [1245, 2091, 2850, 3059, 3243, 3246, 3393, 3510, 4109, 4190, 4945, 4973, 5023, 5046, 5114], 'interactions': [1246], 'demonstrate': [1254, 2650, 3326], 'formation': [1256, 2322, 2449, 2498, 2512, 3190, 3299, 3328, 4011, 4085, 4172, 4572], 'Binding': [1268], 'binary': [1271, 2533, 3193, 4175], 'CcpA·Ser(P)': [1272, 2459], 'clearly': [1279, 2253], 'distinguishable': [1280], 'nonspecific': [1283, 2238], 'Additionally,': [1297], 'repression.': [1327], 'His6-CcpA': [1328], 'fromBacillus': [1329], 'megaterium': [1330, 4757], 'was': [1331, 1385, 1394, 1422, 1454, 1487, 1540, 1580, 1648, 1697, 1707, 1762, 1810, 1834, 1913, 1923, 2606, 2871, 2898, 3230, 3507, 3640], 'purified': [1332, 1423, 1459, 1511, 1855, 3749, 5157], 'using': [1333, 1396, 1787, 1975, 2875], 'resin': [1336], '(Qiagen)': [1337], 'described': [1339, 1425, 1461, 1513], 'previously': [1340, 1426, 1462, 1514], '15Hueck': [1362, 3694], 'Kraus': [1364, 3696], 'Schmiedel': [1366, 3698], '16:': [1373, 3705], '855-864Crossref': [1374, 3706], '(61)': [1377, 3709], 'Following': [1380], 'imidazole,': [1383], 'dialyzed': [1386, 1896], '10': [1388, 1543, 1649, 1671, 1727, 1840], 'mm': [1389, 1544, 1655, 1672, 1678, 1688, 1721, 1728, 1841, 1900, 2248, 4608], 'Tris-HCl': [1390, 1673], '(pH': [1391, 1651, 1674, 1904], '7.5).': [1392], 'Protein': [1393, 1797, 3473, 4308, 4648], 'quantified': [1395, 1581], 'method': [1398], 'Gill': [1400], 'von': [1402, 1406], 'Hippel': [1403, 1407], '(16Gill': [1404], 'S.C.': [1405], 'P.H.': [1408], 'Anal.': [1409], 'Biochem.': [1410], '1989;': [1411, 1475], '182:': [1412], '319-326Crossref': [1413], '(5073)': [1416], '(17Reizer': [1427], 'Sutrina': [1429], 'S.L.': [1430], 'Wu': [1431], 'L.-F.': [1432], 'Reddy': [1435], 'P.': [1436, 3466, 3549, 4301, 4634, 5067], '9158-9169Abstract': [1445], 'generated': [1455, 2899, 3641], '(18Wittekind': [1463], 'Klevit': [1472, 3467, 4302, 4646], 'R.E.': [1473, 3468, 4303, 4647], 'Biochemistry.': [1474, 3413], '28:': [1476], '9908-9912Crossref': [1477], '(83)': [1480], 'Scholar).15N': [1482], 'isotopic': [1483], 'labeling': [1484], 'accomplished': [1488, 1811, 1930], 'minimal': [1493], 'medium': [1494], '[15N]NH4Cl': [1496], '(Isotec)': [1497], 'sole': [1500], 'nitrogen': [1501], 'source.': [1502], 'Synthetic': [1503], 'oligonucleotides': [1504], '(Macromolecular': [1505], 'Resources,': [1506], 'Colorado': [1507], 'State': [1508], 'University)': [1509], 'were': [1510, 1564, 1592, 1603, 1614, 1639, 1660, 1713, 1773, 1844, 1884, 1895, 1929, 1949, 1959, 1973, 2884, 2916, 3173, 3657, 3751, 3764, 4119], '(19Stewart': [1515], 'L.': [1516], 'Ireton': [1517], 'G.C.': [1518], 'Champoux': [1519], 'J.J.': [1520], '271:': [1525, 3552, 5070], '7602-7608Abstract': [1526], '(163)': [1534], 'single-stranded': [1538], 'annealed': [1541], 'MgCl2by': [1545], 'heating': [1546], '70': [1548], '°C': [1549], 'slowly': [1551], 'cooling': [1552], 'room': [1554], 'temperature.': [1555], 'Exact': [1556], 'ratios': [1557], 'each': [1559, 2529, 2891, 2914, 2945, 3117, 3767, 4831, 5104], 'strand': [1560], 'annealing': [1562, 1572], 'reactions': [1563, 1573, 1712], 'determined': [1565, 2489], 'polyacrylamide': [1567], 'gel': [1568, 1737, 2888, 3669, 3716], 'analysis': [1569, 1733], 'multiple': [1571], 'silver': [1575], 'staining.': [1576], 'double-stranded': [1578], 'assumingA': [1582], '260': [1583], '-': [1584], '1.0': [1585], 'corresponds': [1586], '33': [1588], 'μg/ml.': [1589], 'CD': [1590, 1646, 2001, 2041, 2066, 2164, 2217, 2317, 2359, 2443, 2465, 2505, 2569, 2591, 2626, 2648, 2718, 3324, 4898, 4938, 5136], 'performed': [1593, 1604, 1950, 2860, 3175], 'Aviv': [1596], '62DS': [1597], 'Circular': [1598], 'Dichroism': [1599], 'Spectrapolarimeter.': [1600], 'Typically,': [1601, 1693], '1.5': [1607], 'nm': [1608, 1617, 2179, 2469], 'band': [1609], 'width,': [1610], 'data': [1612, 2445], 'points': [1613, 2883, 3009, 3775], 'taken': [1615, 3010], 'every': [1616], '15-s': [1620], 'averaging': [1621], 'time.': [1622], 'concentrations': [1624, 4155, 4201], 'ranged': [1625], '5': [1627, 1899, 3794, 4157, 4613], '40': [1629, 2597, 2602], 'μm,': [1630], 'either': [1632, 1735, 2011, 2853, 3796, 4782], '1-': [1633], '10-mm': [1635], 'path': [1636], 'length': [1637], 'cuvettes': [1638], 'used.': [1640], 'buffer': [1642, 1684, 1903], 'mmTris-HCl': [1650], '7.5)': [1652, 1675], 'containing': [1653, 1676, 2048], '150': [1654, 2247], 'NaCl.': [1656, 1679, 2249], 'carried': [1661, 1885], 'out': [1662, 1886, 2693], 'trypsin,': [1664, 2876], 'chymotrypsin,': [1665, 2877], 'clostripain': [1667, 1681, 1816, 3020], '(Worthington': [1668], 'Enzymes)': [1669], '50': [1677, 1862], 'For': [1680, 1754], 'digests,': [1682], 'also': [1685, 2746, 3174, 3737, 4335, 4546], 'contained': [1686], '1': [1687, 1691, 1698, 1716, 1720, 2305], 'CaCl2': [1689], 'mmdithiothreitol.': [1692], 'concentration': [1696, 1767, 1820], 'mg/ml,': [1699], 'ratio': [1702, 1824], 'substrate': [1704], 'protease': [1706], '100:1': [1708, 1822], '(w/w).': [1709], 'Time': [1710], 'course': [1711], 'quenched': [1714, 1835], 'mm1-chloro-3-tosylamido-7-amino-2-heptanone': [1717], '(for': [1718, 1724, 1730, 2018], 'trypsin),': [1719], 'phenylmethylsulfonyl': [1722], 'fluoride': [1723], 'chymotrypsin),': [1725], 'EDTA': [1729], 'clostripain)': [1731, 1828], 'before': [1732, 1942], 'SDS-polyacrylamide': [1736, 2887], 'electrophoresis': [1738], '(20Laemmli': [1739], 'U.K.': [1740], 'Nature.': [1741], '1970;': [1742], '227:': [1743], '680-685Crossref': [1744], '(207537)': [1747], 'Scholar)': [1749, 3099, 3557, 4273, 4317, 4377, 4812], 'MALDI-TOF': [1751, 1770, 2919, 5143], 'spectrometry.': [1753], 'samples': [1755, 2955], 'analyzed': [1756, 2885, 2917], 'spectrometry,': [1759], 'trifluoroacetic': [1760], 'acid': [1761, 1789, 4728], 'added': [1763, 3503], 'final': [1766], '0.1%.': [1769], 'spectra': [1772, 1958, 2067, 2285, 2301, 2401, 2427, 2719, 2952, 2995, 3002, 3491, 3763, 3772], 'recorded': [1774, 1960], 'Perceptive': [1777], 'Biosystems': [1778], 'Voyager': [1779], 'Elite': [1780], '(University': [1781], 'Washington': [1783], 'Mass': [1784, 3001], 'Spectrometry': [1785], 'Facility)': [1786], '3,5-dimethoxy-4-hydroxy-cinnamic': [1788], 'matrix': [1792], '(21Kowalak': [1793], 'Walsh': [1795], 'K.A.': [1796], 'Sci.': [1798, 2126, 4649], '5:': [1800], '1625-1632Crossref': [1801], 'Purification': [1807], 'CcpA-C': [1809, 1883, 1922, 3712, 3750, 3804, 3847, 4064, 4146], 'limited': [1813, 2861, 3012, 3643], '(1': [1817], 'mg/ml': [1818], '(w/w)': [1823], '90': [1830], 'min.': [1831], 'reaction': [1833], 'addition': [1838, 1933, 3781], 'EDTA.': [1842], 'Samples': [1843, 2912], 'lyophilized,': [1845], 'resuspended': [1846], 'one-tenth': [1848], 'original': [1850], 'volume': [1851], 'H2O,': [1853], 'size': [1857, 3840], 'exclusion': [1858], 'chromatography': [1859], '×': [1863, 1968], '2-cm': [1864], 'Sephacryl': [1865], 'S-100': [1866], '(Pharmacia': [1868], 'Biotech': [1869], 'Inc.).': [1870], 'Titrations': [1871, 1928], 'uniformly15N-labeled': [1873], '(0.5': [1875], 'mm)': [1876, 1881], '(0.4': [1880], '30': [1888, 2152], '°C.': [1889], 'appropriate': [1891], 'amounts': [1892], 'extensively': [1897], 'sodium': [1901], 'phosphate': [1902, 4885], '6.9)': [1905], 'lyophilized.': [1907], 'dissolved': [1914, 1924], '500': [1916], 'μl': [1917], '10%2H2O/90%': [1919], 'H2O;': [1920], '100': [1926, 3217], 'μl.': [1927], 'followed': [1936, 3665], '15-min': [1939], 'equilibration': [1940], 'period': [1941], 'recording': [1943], '[1H-15N]HSQC': [1945, 1957, 3490], 'spectra.': [1946, 3520], 'Bruker': [1953], 'DMX-500': [1954], 'MHz': [1955], 'spectrometer.': [1956], 'spectral': [1962, 4939], 'widths': [1963, 3945], '7002': [1965], 'Hz': [1966, 1970], '(1H)': [1967], '2000': [1969], '(15N).': [1971], 'Data': [1972], 'processed': [1974], 'NMRPipes': [1976], '(22Delaglio': [1977], 'F.': [1978], 'Grzesiek': [1979], 'Vuister': [1981], 'G.W.': [1982], 'Zhu': [1983], 'Pfeifer': [1985], 'Bax': [1987], 'Biomol.': [1990], 'NMR.': [1991], '6:': [1993], '277-293Crossref': [1994], '(11638)': [1997], 'Near-UV': [2000], 'demonstrated': [2004], 'sensitive': [2007, 2509], 'changes': [2009, 4081, 4137, 4894, 4940], 'environment': [2013, 3824], 'review': [2019], 'see': [2020], 'Ref.': [2021], '23Gray': [2022], 'D.M.': [2023], 'Ratliff': [2024], 'R.L.': [2025], 'Vaughan': [2026], 'M.R.': [2027], 'Methods': [2028], 'Enzymol.': [2029], '211:': [2031], '389-406Crossref': [2032], '(252)': [2035], 'Therefore,': [2038, 4068, 4768], 'studies': [2042, 2759, 3656, 4616], 'monitor': [2044], 'oligonucleotide': [2047, 2073, 2572], 'consensus': [2050, 2100], 'without': [2060], 'Fig.1': [2063], 'shows': [2064], '26-base': [2070], 'pair': [2071, 2099], 'duplex': [2072, 2150], '5′-GGGCTGATTTGAAAGCGCTAACAGGG-3′': [2089], 'complement,': [2092], 'where': [2093, 3964], 'underlining': [2095], 'denotes': [2096], '14-base': [2098], 'cresequence': [2101], '24Weickert': [2119], 'Proc.': [2123], 'Natl.': [2124], 'Acad.': [2125], '1990;': [2130], '87:': [2131], '6238-6242Crossref': [2132], '(232)': [2135], 'equimolar': [2142], 'amount': [2143], 'dimer': [2146, 2563, 2605, 3678, 3741, 3848], '(30': [2147], 'μm': [2148, 2153, 2598, 2603, 2612, 3214, 3222], 'dimer)': [2155], 'moderate': [2159], 'change': [2160, 2315, 2463, 2566, 2589, 3225, 4005, 4032, 4628, 4908, 5021, 5088], 'spectrum': [2165, 2218, 2232, 2276, 3811, 4017, 4899], 'compared': [2166, 2405], 'free': [2168, 2230, 2279, 3894, 3916, 3948, 3976, 3991], 'DNA;': [2169], 'there': [2170, 2235, 4723], 'slight': [2173, 2182], 'decrease': [2174, 2206], 'ellipticity': [2176, 2185, 2208], 'near': [2177, 4232], '265': [2178], 'increase': [2183, 2704, 4525, 4587], '∼285': [2187], 'nm.': [2188, 2212], 'However,': [2189, 2250, 4702], '(60': [2195], 'μm)': [2196, 2341, 2352], 'much': [2199], 'more': [2200], 'pronounced': [2201], 'changes,': [2202, 4143], 'maximal': [2205], 'occurring': [2209, 3898], '∼267': [2211], 'different': [2227, 2254, 2415, 4686], 'suggests': [2233, 2440, 3151, 3890, 4331, 4513], 'DNA,': [2244, 2710, 3183, 3597, 4826, 4845, 4911, 5160], 'even': [2245, 4152], 'what': [2256], 'observed': [2258, 2319, 2395, 2961, 3516, 3601, 3928, 4059, 4605, 4941], 'Identical': [2265], 'obtained': [2268], 'under': [2269], 'low': [2270, 4200], 'ionic': [2271], 'strength': [2272], 'conditions;': [2273], 'slightly': [2282], '+': [2288, 2292, 2294, 2722, 2726, 2728], 'superimposable': [2298], 'Fig.': [2304, 2356, 3105, 3769, 3793, 4612], '(data': [2306, 2615, 3744], 'shown).': [2308, 3746], 'took': [2310], 'advantage': [2311], 'large': [2314, 2973, 3839, 4672, 4893], 'protein-DNA': [2325], 'determine': [2328, 2551, 2923, 3187], 'apparent': [2330, 2480, 3721, 4524, 4770, 4959], 'constant.': [2332], '(5': [2340], 'excess': [2348], '(40': [2351], '2.': [2357], 'showed': [2361, 4135], 'clear': [2363], 'isodichroic': [2364, 2387, 2418], 'point': [2365, 2419, 3160], '(at': [2366], '278': [2367], 'nm),': [2368], 'indicating': [2369, 2628, 3727, 4144], 'simple': [2372], 'two-state': [2373], 'equilibrium': [2374], 'can': [2375, 3514, 4334, 5036], 'obtain': [2379], 'approximate': [2381], 'affinity.': [2382], 'point,': [2388], 'same': [2393], 'wavelength': [2394], 'comparison': [2398, 2424, 4858], 'alone': [2404], '(Fig.': [2410, 2956, 4156, 4748], '1)': [2411], '(∼273': [2420], 'nm)': [2421], 'complex,': [2438, 2516], 'strongly': [2439], 'monitoring': [2447], 'complex.': [2461], '267': [2468], 'well': [2471], 'fit': [2472], 'event': [2477], 'K': [2481, 2490, 4771], 'd': [2482, 2491, 4569, 4772], '4.5': [2484], '±': [2485], '0.5': [2486, 4607], 'μm.': [2487], 'represents': [2492], 'theapparent': [2493], 'dissociation': [2494, 2525, 3309], 'constant': [2495], 'complex;': [2502], 'possible': [2520, 2532, 3304], 'measure': [2522], 'true': [2524], 'constants': [2526], 'directly': [2527, 2691, 3348, 3517], 'complexes.': [2534], 'measured': [2536, 4773], 'affinity': [2537, 2682, 2706, 4527, 4589], 'range': [2546], 'allowed': [2548], 'us': [2549, 5155], 'stoichiometry': [2553], 'signal.': [2570], 'contains': [2574, 2641], 'one': [2576, 2585, 5108], 'sufficient': [2582, 3653], 'dimer.': [2587], 'during': [2593, 3011], 'essentially': [2607], 'linear': [2608], 'up': [2609], '80': [2611], 'shown);': [2617], 'further': [2618, 2622, 2909], 'additions': [2619], 'had': [2620], 'effect': [2623, 3511, 4558], 'saturation': [2630], 'reached.': [2633], 'These': [2634, 3274], 'existence': [2652], 'supports': [2666], 'hypothesis': [2668], 'necessary': [2673], 'high': [2681], 'sequences.': [2685], 'Although': [2686, 5003], 'do': [2689, 4001], 'rule': [2692], 'possibility': [2695], 'function': [2698, 3501, 4020], 'otherwise,': [2713], 'differences': [2715, 3911, 4729], 'suggest': [2731, 4474], 'does': [2735, 4147, 4350, 4623], 'alter': [2736], 'mode': [2738, 4817, 4974], 'CcpA.': [2743, 3000, 3504, 4494, 4565, 4822], 'indicates': [2747, 4863], 'sequences;': [2755], 'show': [2768], 'withincre': [2771], '9Kim': [2791], 'suggesting': [2830, 4347, 4666, 4912], 'only.': [2842], 'effort': [2845], 'further,': [2858], 'experiments.': [2863], 'Full-length': [2864], '(monomeric': [2866], '∼39': [2869], 'kDa)': [2870], 'subjected': [2872], 'clostripain,': [2879, 3664], 'time': [2882, 3008, 3904], 'electrophoresis.': [2889], 'case,': [2892, 5078], 'fragment': [2894, 2975, 3605], '∼31': [2896], 'kDa': [2897, 3851, 3859], 'within': [2900, 4225, 5089], 'first': [2902], 'minute': [2903], 'remained': [2905], 'relatively': [2906], 'resistant': [2907], '(Fig.3).': [2911], 'digest': [2915], 'spectroscopy': [2921, 3402], 'prominent': [2925], 'cleavage': [2926, 2942, 3119], 'sites.': [2927], 'Some': [2928], 'fragments': [2929, 2960, 3110], 'whose': [2930, 3823], 'identity': [2931], 'could': [2932], 'unambiguously': [2934], 'assigned': [2935], 'their': [2938], 'molecular': [2939, 3722], 'sites': [2943], 'indicated': [2948, 3343], 'representative': [2950], '4).': [2957], '∼31-kDa': [2959], 'protease-resistant': [2963], 'bands': [2964], 'SDS': [2967], 'gels': [2968], 'all': [2969, 3142, 3998], 'correspond': [2970], 'begins': [2977], 'residues': [2979, 3147, 4194, 4224, 4750, 4874], '54': [2980, 3148], '59': [2982, 3150], 'extends': [2984], 'C': [2987], 'terminus': [2988], 'Lys332.Figure': [2992], '4MALDI-TOF': [2993], 'digests': [2998], '2-min': [3007], 'trypsin': [3015], '(A),': [3016], 'chymotrypsin': [3017], '(B),': [3018], '(C).': [3021], 'schematic': [3023], 'homology': [3034, 3062], 'PurR': [3036, 3072, 3559, 4834, 4862, 4943, 5158], 'above': [3039], 'A.View': [3040], 'Large': [3041], 'Image': [3042], 'Figure': [3043], 'ViewerDownload': [3044], 'Hi-res': [3045], 'image': [3046], 'Download': [3047], '(PPT)': [3048], 'predicted': [3056], 'strong': [3060], 'LacI,': [3069], 'GalR,': [3070], '25Chauvaux': [3088], '147:': [3093], '518-522Crossref': [3094], '(18)': [3097], 'schematically': [3103], '4.': [3106], 'initial': [3108, 4482, 5150], 'consistent': [3112, 4343, 4903], 'proposal;': [3115], 'protease,': [3118], 'domain,': [3133, 3730, 3736], 'producing': [3134], 'stable': [3136], 'fragment.': [3138], 'three': [3143, 4726], 'proteases': [3144], 'cleave': [3145], 'most': [3156, 3807, 4073, 4106], 'likely': [3157, 3585], 'separation': [3159], 'whether': [3188, 4337], 'would': [3197], 'lead': [3198], 'cleavage.': [3204], 'Under': [3205], 'conditions': [3207], '(typically': [3212], '20–30': [3213], 'monomer,': [3216], 'μmSer(P)': [3218], '60': [3221], 'DNA),': [3223], 'observed;': [3231], 'contrast': [3235, 3879], 'PurR,': [3242], 'corepressor,': [3244], 'cognate': [3247, 4946], '(26Choi': [3250], 'K.Y.': [3251, 3263, 3563, 4799], 'Zalkin': [3252, 3264, 3564, 4800], 'H.': [3253, 3265, 3565, 4801], '174:': [3257], '6207-6214Crossref': [3258], '27Choi': [3262], '1767-1772Crossref': [3270], 'susceptibility': [3279], 'linker': [3282], 'greatly': [3295], 'altered': [3296, 3826], 'complexes': [3305], 'sufficiently': [3316], 'fast': [3317, 3901, 3922], 'allow': [3319], 'occur.': [3322], 'cre-DNA,': [3335], 'Previous': [3340], 'elution-retardation': [3341], 'Scholar);': [3370], 'question': [3373], 'remains': [3374], 'regions': [3378], 'important': [3385, 4677], 'interaction.': [3388], 'Interactions': [3389], 'partners': [3396], 'characterized': [3399], '(28Garrett': [3403], 'D.S.': [3404], 'Seok': [3405], 'Y.-J.': [3406], 'Peterkofsky': [3407], 'Clore': [3409], 'G.M.': [3410], 'Gronenborn': [3411], 'A.M.': [3412], '36:': [3415], '4393-4398Crossref': [3416], '(209)': [3419], '29Van': [3422], 'Nuland': [3423, 3446, 4255, 4278], 'N.A.': [3424, 3447, 4256, 4279], 'Kroon': [3425, 4280], 'G.J.': [3426, 4281], 'Dijkstra': [3427, 4282], 'K.': [3428, 3620, 4283, 4632], 'Wolters': [3429, 4284], 'G.K.': [3430, 4285], 'Scheek': [3431, 3450, 4259, 4286], 'R.M.': [3432, 3451, 4260, 4287], 'Robillard': [3433, 3452, 4261, 4288], 'G.T.': [3434, 3453, 4262, 4289], 'FEBS': [3435, 4290], 'Lett.': [3436, 4291], '315:': [3438, 4293], '11-15Crossref': [3439, 4294], '(56)': [3442, 4297], '30Van': [3445], 'Boelens': [3448, 4257], '246:': [3458, 4267], '180-193Crossref': [3459, 4268], '(80)': [3462, 4271], '31Rajagopal': [3465, 4300], 'Crabb': [3469, 4304], 'Techniques': [3471, 4306], 'Chemistry': [3474, 4309], 'Academic': [3476, 4311], 'Press,': [3477, 4312], 'Lake': [3478, 4313], 'Placid,': [3479, 4314], 'NY1994:': [3480, 4315], '439-445Google': [3481, 4316], 'employed': [3484], 'approach,': [3487], 'of15N-labeled': [3492], '(or': [3494], 'monitored': [3498], 'Because': [3505], 'isotopically15N-labeled,': [3509], 'similarities': [3524], 'three-dimensional': [3529, 5041], 'structures': [3530, 5042], 'LacI': [3533, 3607, 5044, 5083], '(32Lewis': [3534, 5052], 'Chang': [3536, 5054], 'Horton': [3538, 5056], 'N.C.': [3539, 5057], 'Kercher': [3540, 5058], 'M.A.': [3541, 3545, 3561, 4797, 5059, 5063], 'Pace': [3542, 5060], 'H.C.': [3543, 5061], 'Schumacher': [3544, 5062], 'Brennan': [3546, 3566, 4802, 5064, 5148], 'R.G.': [3547, 3567, 4803, 5065], 'Lu': [3548, 5066], 'Science.': [3550, 3568, 4804, 5068], '1247-1254Crossref': [3553, 5071], '(659)': [3555, 5073], '(33Schumacher': [3560, 4796], 'Choi': [3562, 4798], '763-769Crossref': [3571, 4807], '(335)': [3574, 4810], 'reasoned': [3578], 'HPr;': [3590, 4219], 'N-terminal': [3592], 'presumably': [3595], 'binds': [3596], 'corresponding': [3608], '(34Platt': [3615], 'T.': [3616], 'Files': [3617], 'J.G.': [3618], 'Weber': [3619], '1973;': [3624], '248:': [3625], '110-121Abstract': [3626], 'test': [3634], 'hypothesis,': [3636], 'purified.': [3646], 'Quantities': [3647], '(CcpA-C)': [3652], 'treatment': [3660], 'purification': [3667], 'filtration.': [3670], 'Similar': [3671], 'intact': [3673, 4117, 4127], 'elutes': [3713], 'filtration': [3717], '∼60': [3725], 'kDa,': [3726], 'exists': [3738], 'solution': [3743], 'Aliquots': [3747], 'titrated': [3752], 'into': [3753, 4065, 4815], 'sample': [3755], '0.4': [3757], 'mm15N-labeled': [3758], 'collected': [3765], 'addition.': [3768], '5shows': [3770], '[15N-1H]HSQC': [3771], 'titration.': [3778], 'Upon': [3779, 4823], '0.25': [3783], 'mol': [3784], 'equivalents': [3785], 'subset': [3788, 3887], 'resonances': [3790, 3822, 3862, 3913, 3999, 4028, 4069], '(indicated': [3791], 'A)': [3795], 'broaden': [3797, 4037], 'dramatically': [3798], 'disappear': [3800, 4013, 4039, 4090], 'completely.': [3801], 'As': [3802], 'additional': [3803, 3954], 'added,': [3806], 'peaks': [3808], 'disappear.': [3813], 'behavior': [3815, 4058], 'indicative': [3817], 'line': [3819, 3929, 3944, 4141], 'broadening': [3820], 'CcpA-C.': [3834, 4112], 'Unfortunately,': [3835, 4113], 'due': [3836, 4044, 4082, 4121], '(∼80': [3844], 'kDa;': [3845], '∼62': [3850], '9': [3858], 'each),': [3860], 'observed.': [3871], 'gradual': [3873], 'disappearance': [3874, 3884], 'nonperturbed': [3876], 'resonances,': [3877, 3889], 'very': [3882, 4244], 'rapid': [3883], 'exchange': [3892, 3925, 3956], 'bound': [3896, 3918, 3950, 3978, 3993, 4025], 'intermediate': [3903, 3924], 'regime': [3905], '(relative': [3906], 'chemical': [3909, 3955, 3985, 4007, 4034, 4051, 4079], 'shift': [3910, 3986, 4008, 4035, 4052, 4080], 'states).': [3919], '2In': [3920], 'regime,': [3926], 'width': [3930, 4142], 'peak': [3933], 'will': [3934, 4012, 4036], 'sum': [3937], 'population-weighted': [3940], 'average': [3941], 'species': [3951, 3979, 4708, 4733], 'contribution': [3957], 'scales': [3959], 'asf': [3960], 'f': [3961, 3962, 3965, 3966, 3968], 'bΔωfb2,': [3963], 'b': [3969], 'mole': [3972, 4022], 'fractions': [3973], 'Δωfbis': [3981], 'difference': [3983], '(in': [3987], 'Hz)': [3988], 'species.': [3994], 'predicts': [3996], 'undergo': [4003, 4030], '(broaden)': [4014], 'fraction': [4023], 'species,': [4026], 'early': [4040, 4091], 'squared': [4047], 'dependence': [4048], 'perturbation.': [4053], 'precisely': [4056], 'perturbed': [4072], 'consequently': [4075], 'largest': [4078], 'should': [4089], 'titration,': [4094], 'allowing': [4095, 4425], 'determination': [4098], 'portions': [4101], 'affected': [4107], 'impossible': [4120], 'insufficient': [4123], 'solubility': [4124], 'protein.': [4128], 'neither': [4136], 'intensity': [4139], 'nor': [4140], 'millimolar': [4154], 'D).': [4158, 4614], 'Thus,': [4159, 4437, 4658], 'confirm': [4163], 'absolutely': [4184], 'requires': [4185], 'state.': [4192], 'selectively': [4197], 'broadened': [4198], '(Fig.6).': [4211], 'comprises': [4215], 'α-helices': [4217], 'Helix': [4220, 4235], 'A,': [4221], 'includes': [4223, 4238], 'active': [4227], '(residues': [4231], 'His15),': [4233], 'B,': [4236], 'Ser46.': [4239], 'Interestingly,': [4240, 4407], 'recognized': [4249], '(30Van': [4254], 'IIA': [4276, 4414], '(29Van': [4277], 'His15': [4330, 4357, 4381], 'discriminate': [4336], 'previous': [4345], 'mutated': [4379], '(35Reizer': [4382], '5480-5486Crossref': [4403], 'diminished': [4420], 'Ser46,': [4424], 'sense': [4429], 'regulatory': [4439, 5115], 'coordinates': [4446], 'functions': [4448], 'enzymes.': [4459], 'presented': [4462], 'here': [4463], 'shed': [4464], 'light': [4465, 4971], 'particular': [4476], 'order': [4477], 'events': [4479], 'must': [4517, 4660, 5011, 5121], 'precede': [4518], 'recognition': [4520], 'cresequences.': [4522], 'support': [4547], 'events.': [4551], 'It': [4552, 4675], 'remarkable': [4554], 'consider': [4556], 'Ser46phosphorylation': [4560], 'Considering': [4566], 'apparentK': [4568], '(4.5': [4577], 'μm),': [4578], 'least': [4594], '3': [4595], 'orders': [4596], 'magnitude': [4598], 'over': [4599], '(no': [4602], 'revealed': [4618], 'induce': [4625], 'conformational': [4627, 5087], '(36Pullen': [4631], 'Rajagopal': [4633], 'Branchini': [4635], 'B.R.': [4636], 'Huffine': [4637], 'M.E.': [4638], 'Scholtz': [4644], 'J.M.': [4645], '4:': [4651], '2478-2486Crossref': [4652], '(40)': [4655], 'phosphoserine': 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