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1252, 1385, 1430, 1460, 1465, 1545, 1781, 1788, 1959, 1969, 2175, 2225, 2282, 2345, 2428, 2664, 2667, 3237, 3361, 3467], 'Restless': [8, 218, 824, 839, 2830, 2911, 3081, 3089, 3243, 3263, 3376, 3408, 3468, 3498, 3525, 3548], 'Syndrome:': [10, 2819, 3470], 'A': [11, 1484, 2322, 2598, 2826, 3270, 3321, 3324, 3348, 3351, 3380, 3415, 3457, 3505], 'Randomized': [12, 3432], 'Crossover': [13], 'Study': [14, 841, 2914, 3084, 3092, 3188], 'Anouk': [15, 35, 42], 'D.': [16, 36], 'Rozeman,': [17, 37, 43], 'M.D.,': [18, 28, 33, 103, 118], 'Truus': [19, 76], 'Ottolini,': [20], 'Diana': [21, 86], 'C.': [22, 87], 'Grootendorst,': [23, 88], 'Ph.D.,': [24, 29], 'Oscar': [25, 100], 'J.M.': [26, 101], 'Vogels,': [27, 102], 'Roselyne': [30, 115], 'M.': [31, 116], 'Rijsman,': [32, 117], 'Ph.D.': [34, 89, 104, 119], 'M.D.': [38], 'Address': [39], 'correspondence': [40], 'to:': [41], 'Center': [44, 52, 68, 78, 93, 120, 779, 786, 1048], 'for': [45, 69, 79, 121, 594, 780, 805, 888, 1005, 1119, 1162, 1221, 1628, 1682, 1883, 1908, 2101, 2132, 2137, 2143, 2306, 2339, 2390, 2496, 2617, 2636, 2716, 2888, 2930, 2961, 2983, 3010, 3023, 3041, 3096, 3142, 3435, 3446, 3586, 3596], 'Sleep': [46, 70, 80, 122, 407, 781, 1624, 2843, 2884, 2917, 3025, 3055, 3073, 3100, 3170, 3203, 3274, 3290, 3419, 3509, 3531, 3558, 3608], '-': [47], 'and': [48, 71, 74, 81, 84, 123, 126, 205, 211, 228, 253, 273, 299, 328, 381, 441, 546, 555, 559, 571, 616, 689, 711, 782, 790, 846, 876, 971, 1021, 1032, 1035, 1095, 1159, 1183, 1188, 1212, 1217, 1335, 1463, 1476, 1500, 1552, 1605, 1630, 1668, 1829, 1841, 1932, 1994, 2016, 2088, 2094, 2119, 2140, 2190, 2202, 2243, 2354, 2370, 2510, 2563, 2587, 2626, 2784, 2824, 2834, 2890, 2898, 2926, 2944, 3136, 3186, 3216, 3239, 3259, 3271, 3293, 3322, 3349, 3367, 3388, 3394, 3404, 3416, 3443, 3455, 3476, 3481, 3494, 3506, 3546, 3552], 'Wake': [49, 72, 82, 124, 783], 'disorders,': [50, 784], 'Medical': [51, 92, 785, 1047], 'Haaglanden': [53, 787], '(MCH),': [54], 'P.O.': [55], 'Box': [56], '432,': [57], '2501': [58], 'CK': [59], 'The': [60, 62, 95, 97, 112, 1050, 1102, 1229, 1255, 1266, 1283, 1331, 1439, 1591, 1613, 1633, 1703, 1859, 2003, 2122, 2359, 2797, 3079], 'Hague,': [61, 96], 'Netherlands0031-70-33020000031-70-3303113': [63], 'E-mail': [64], 'Address:': [65], '[email': [66], 'protected]': [67], 'Disorders': [73, 83, 125], ',': [75, 85, 99, 114, 3329, 3354, 3398], 'Ottolini': [77, 385], 'Landsteiner': [90], 'Institute,': [91], 'Haaglanden,': [94], 'Netherlands;': [98], 'Department': [105, 792], 'Neurophysiology,': [107, 794], 'St.': [108], 'Antonius': [109, 796], 'Hospital,': [110], 'Nieuwegein,': [111], 'Netherlands': [113], 'Published': [127], 'Online:August': [128], '15,': [129, 3424, 3462, 3576, 3601], '2014https://doi.org/10.5664/jcsm.3964Cited': [130], 'by:11SectionsAbstractPDF': [131], 'ShareShare': [132], 'onFacebookTwitterLinkedInRedditEmail': [133], 'ToolsAdd': [134], 'to': [135, 169, 418, 464, 648, 666, 706, 800, 811, 815, 848, 883, 902, 908, 935, 941, 1028, 1083, 1116, 1154, 1185, 1262, 1324, 1346, 1355, 1372, 1381, 1403, 1425, 1445, 1490, 1514, 1569, 1618, 1687, 1771, 1795, 1811, 1901, 1914, 1962, 1972, 2167, 2214, 2302, 2372, 2458, 2488, 2541, 2570, 2619, 2660, 2684, 2693, 2735, 2780, 2785, 3288, 3473], 'favoritesDownload': [136], 'CitationsTrack': [137], 'Citations': [138], 'AboutABSTRACTStudy': [139], 'Objective:A': [140], 'variety': [141, 492, 626], 'sensory': [143, 154, 175, 207, 213, 291, 352, 360, 395, 428, 494, 628, 654, 663, 731, 745, 760, 1094, 1351, 1363, 1367, 1786, 2090, 2096, 2173, 2222, 2256, 2277, 2316, 2382, 2668, 2674, 2726, 2766, 3192, 3238], 'stimuli': [144, 361, 396, 495, 629, 1384, 2174], 'relieve': [145, 497, 631], 'restless': [146, 157, 178, 363, 398, 657, 674, 2931, 2945, 2965, 2984, 3011, 3042, 3069, 3097, 3119, 3146, 3166, 3195, 3311, 3447], 'legs': [147, 158, 179, 219, 364, 399, 410, 593, 658, 675, 735, 1145, 2932, 2946, 2966, 2985, 3012, 3043, 3070, 3098, 3120, 3147, 3167, 3196, 3218, 3312, 3448, 3612], 'syndrome': [148, 159, 180, 220, 365, 411, 659, 3013, 3044, 3168, 3313], 'symptoms.': [149, 499, 1064, 2227, 2284, 2395], 'Because': [150, 1203], 'systematic': [151, 635], 'evaluations': [152, 636], 'stimulation': [155, 176, 201, 208, 214, 655, 1246, 1299, 1924, 1936, 2084, 2091, 2097], 'in': [156, 244, 250, 255, 286, 319, 325, 332, 345, 348, 576, 579, 607, 670, 756, 943, 985, 1033, 1054, 1136, 1209, 1306, 1311, 1340, 1358, 1565, 1575, 1695, 1705, 1816, 1988, 1997, 2012, 2040, 2151, 2199, 2248, 2252, 2327, 2349, 2355, 2377, 2398, 2437, 2465, 2506, 2516, 2549, 2582, 2610, 2678, 2700, 2709, 2720, 2722, 2762, 2860, 2895, 2902, 3049, 3140, 3194, 3297, 3372, 3590, 3620], 'are': [160, 450, 640, 2979], 'largely': [161], 'lacking,': [162], 'we': [163, 750, 1557, 1791, 1802, 2210, 2461, 2537, 2731, 2752], 'performed': [164, 643, 751, 1044, 1053, 1402, 1686, 1766, 2162, 2449], 'a': [165, 263, 266, 339, 377, 401, 491, 507, 519, 530, 549, 574, 599, 625, 644, 685, 752, 832, 855, 1079, 1126, 1140, 1275, 1318, 1361, 1365, 1431, 1454, 1599, 1606, 1716, 1754, 1797, 1813, 1825, 2163, 2216, 2231, 2303, 2373, 2404, 2517, 2520, 2527, 2543, 2579, 2590, 2714, 2737, 2755, 2905, 3007, 3015, 3050, 3315], 'randomized': [166, 402, 645, 753, 1220, 1380, 2164], 'crossover': [167, 403, 646, 754, 2165], 'study': [168, 516, 603, 647, 755, 1025, 1197, 1231, 1307, 1838, 2166, 2269, 2419, 2575, 2596, 2680, 2704], 'evaluate': [170, 649, 1084, 1688], 'the': [171, 190, 193, 279, 282, 287, 346, 422, 445, 460, 489, 504, 537, 543, 563, 592, 613, 650, 726, 734, 738, 742, 763, 773, 778, 788, 791, 802, 821, 837, 891, 909, 944, 952, 986, 997, 1017, 1024, 1029, 1046, 1055, 1058, 1085, 1090, 1093, 1112, 1132, 1163, 1167, 1175, 1193, 1210, 1218, 1225, 1234, 1248, 1263, 1269, 1278, 1287, 1292, 1301, 1314, 1322, 1328, 1349, 1375, 1383, 1387, 1390, 1408, 1412, 1418, 1466, 1480, 1488, 1492, 1505, 1515, 1528, 1534, 1546, 1550, 1559, 1619, 1660, 1669, 1674, 1677, 1700, 1712, 1734, 1739, 1745, 1772, 1782, 1819, 1837, 1902, 1926, 1939, 1983, 1986, 1995, 2008, 2053, 2066, 2075, 2115, 2154, 2169, 2205, 2220, 2238, 2241, 2244, 2249, 2260, 2267, 2272, 2280, 2314, 2356, 2381, 2385, 2391, 2411, 2429, 2440, 2447, 2453, 2463, 2469, 2477, 2482, 2493, 2497, 2499, 2572, 2593, 2603, 2622, 2627, 2630, 2637, 2673, 2694, 2703, 2710, 2744, 2829, 2838, 2909, 2962, 3019, 3066, 3087, 3143, 3184, 3373, 3436, 3439, 3547, 3621, 3625], 'effect': [172, 532, 551, 651, 693, 1086, 1352, 1368, 1783, 2170, 2218, 2273, 2344], 'external': [174, 351, 540, 587, 653, 759, 1395, 1785, 2172, 2221, 2255, 2275, 2286, 2315, 2330, 2415, 2725, 2748, 2765, 3002, 3037], 'symptoms.Methods:Eighteen': [181], 'patients': [182, 305, 469, 581, 671, 767, 809, 894, 931, 938, 947, 974, 982, 989, 1062, 1066, 1113, 1134, 1170, 1422, 1729, 1807, 1835, 1853, 1869, 1879, 2109, 2350, 2467, 2565, 2646], 'underwent': [183, 1067, 2468], '3': [184, 195, 257, 334, 1068, 1195, 1226, 1230, 1295, 1343, 1419, 1529, 1678, 1701, 1713, 1740, 1999, 2017, 2042, 2054], 'consecutive': [185, 1069, 1110, 1227, 1237, 1516, 2116, 2180], 'suggestive': [186], 'immobilization': [187, 284, 1071, 2069, 2078, 3610], 'tests': [188, 1072, 1133, 1681, 3135], 'with': [189, 289, 421, 536, 562, 585, 1143, 1244, 1297, 1300, 1393, 1468, 1726, 1753, 1767, 1824, 1856, 1922, 1934, 2081, 2400, 2519, 2534, 2647, 2764, 2904, 3314], 'order': [191, 1219, 2464], 'following': [194], 'conditions': [196, 288, 347, 1198, 1214, 1232, 1714, 1741, 1821, 2013, 2043, 2055, 2156, 2251, 2553, 2721, 2763], 'randomly': [197], 'assigned:': [198], 'no': [199, 605, 1472, 2082, 2148, 2801], 'electrical': [200, 1242, 1245, 1270, 1298, 1394, 1923, 1935, 2083, 2276, 2608, 2631, 2749], '(condition': [202, 209, 216, 1919, 1930, 1943, 2085, 2092, 2099], '1),': [203, 1920, 2086], 'tactile': [204, 212, 290, 1350, 1362, 2087, 2095], 'proprioceptive': [206, 1366, 2089], '2),': [210, 2093], 'only': [215, 1310, 2098, 2645, 2713], '3).': [217], 'symptoms': [221, 429, 433, 535, 578, 611, 850, 1097, 1885, 2434, 2625, 2742, 3193, 3241], 'were': [222, 234, 315, 583, 770, 880, 900, 912, 932, 939, 948, 983, 1026, 1043, 1052, 1114, 1151, 1178, 1201, 1215, 1337, 1379, 1401, 1423, 1496, 1525, 1587, 1615, 1685, 1736, 1742, 1760, 1765, 1792, 1854, 1896, 1945, 1985, 2010, 2026, 2129, 2147, 2197, 2211, 2368, 2426, 2560, 2650, 2732], 'quantified': [223], 'by': [224, 415, 452, 820, 862, 2188, 3257], 'visual': [225, 236, 269, 274, 1432, 1485], 'analog': [226], 'scales,': [227], 'periodic': [229, 308, 474, 1519, 1634, 1873, 2861, 2892, 3137], 'leg': [230, 309, 343, 668, 697, 1415, 1428, 1520, 1571, 1909, 2063, 2071, 2200, 2408, 2858, 3138], 'movements': [231, 310, 476, 1158, 1521, 1875, 2894], 'during': [232, 311, 437, 444, 477, 890, 1100, 1174, 1233, 1417, 1522, 1527, 1573, 1583, 1673, 1876, 2007, 2038, 2114, 2178, 2410, 2589], 'wake': [233, 478, 1523], 'measured.Results:Baseline': [235], 'analogue': [237, 270, 275, 1433], 'scale': [238, 271, 276, 827, 844, 1434, 3095], 'score': [239, 272, 277, 829, 833, 1672, 1862, 2035, 2247], 'was': [240, 262, 354, 768, 859, 1003, 1259, 1272, 1281, 1289, 1294, 1316, 1344, 1369, 1539, 1596, 1644, 1691, 1709, 1846, 1863, 2049, 2230, 2258, 2334, 2417, 2485, 2501, 2705, 2728, 2791], '4.5': [241], '(range': [242, 248, 317, 323, 330], '0-60)': [243], 'condition': [245, 251, 256, 320, 326, 333, 1308, 1313, 1341, 1356, 1725, 1989, 1998, 2020, 2128, 2133, 2138, 2144, 2450], '1,': [246, 321, 3588, 3594, 3598], '10.5': [247], '0-96)': [249], '2,': [252, 327, 1309, 1357, 3426, 3516], '8.5': [254], '(p': [258, 296, 335, 1949, 2029, 2044, 2056], '=': [259, 297, 301, 336, 1950, 2030, 2160], '0.21).': [260], 'There': [261, 2146], 'tendency': [264, 340, 2232, 2405], 'towards': [265, 341, 376, 684, 2233, 2406, 2758], 'higher': [267], 'maximum': [268, 1670, 2004, 2245], 'at': [278, 430, 455, 762, 1045, 1057, 1106, 1139, 1474, 1498, 1598, 1610, 1652, 1659, 1911, 1977, 2237, 2279, 2837], 'end': [280, 1462, 1506, 1661, 1981, 2239], 'suggested': [283, 1070, 2068, 2077], 'test': [285, 1747, 1820, 2079, 2552, 3017], 'stimulation,': [292, 1396], 'though': [293, 634], 'not': [294, 725, 881, 933, 958, 976, 1153, 1793, 1946, 2027, 2050, 2212, 2577, 2733, 2792], 'significant': [295, 1693, 2028, 2149, 2195, 2217, 2490, 2580, 2738], '0.74': [298], 'p': [300, 2159], '0.29,': [302, 2031], 'respectively).': [303], 'Fifteen': [304, 946, 1868], 'suffered': [306, 916, 1871, 2111], 'from': [307, 472, 673, 772, 813, 917, 991, 1321, 1589, 1732, 1872, 2112, 2629, 2656, 2828, 2908, 3199, 3471], 'wake.': [312, 1877], 'Median': [313, 1844, 2062], 'indices': [314, 2125], '18': [316, 1806, 2130, 2535], '0-145)': [318], '26': [322, 1864, 2135], '0-190)': [324], '49': [329, 2141], '0-228)': [331], '0.76).Conclusions:We': [337], 'found': [338, 2198], 'less': [342, 1757, 2407], 'discomfort': [344, 669, 1416, 1429, 1473, 1482, 1910, 2064, 2072, 2186, 2201, 2409, 2628], 'which': [349, 757, 1359, 2253, 2328, 2466, 2707, 2723], 'an': [350, 416, 707, 758, 1721, 2254, 2342, 2414, 2724, 2747, 2793, 2980], 'input': [353, 664, 732, 746, 1787, 2223, 2278, 2317, 2383, 2416, 2669, 2675, 2727], 'applied.': [355], 'This': [356, 677, 2396, 2652, 2768], 'potential': [357, 678, 2421, 2769], 'benefit': [358, 679, 2770], 'severity': [366, 554, 979, 1091, 1205, 1447, 2177, 2508, 2584, 3071], 'merits': [367, 2771], 'further': [368, 2772], 'investigation': [369, 2773], 'as': [370, 457, 459, 818, 1305, 1339, 1353, 1957, 1967, 2336, 2376, 2439, 2492, 2644, 2676, 3006], 'this': [371, 1312, 2048, 2265, 2307, 2319, 2607, 2775], 'could': [372, 680, 719, 957, 2310, 2474, 2601, 2688, 2776], 'open': [373, 681, 2777], 'new': [374, 682, 2778], 'ways': [375, 683, 2779], 'better': [378, 686, 2781], 'pathophysiological': [379, 687, 2782], 'understanding': [380, 688, 2783], 'non-pharmacological': [382, 690, 2786], 'treatments.Citation:Rozeman': [383], 'AD,': [384], 'T,': [386], 'Grootendorst': [387], 'DC,': [388], 'Vogels': [389], 'OJM,': [390], 'Rijsman': [391, 2852, 3272, 3417, 3507], 'RM.': [392], 'Effect': [393], 'syndrome:': [400, 3197], 'study.': [404, 892, 910, 945, 987, 1018, 2796, 3054], 'J': [405, 2865, 2935, 2948, 3387], 'Clin': [406], 'Med': [408], '2014;10(8):893-896.INTRODUCTIONRestless': [409], '(RLS)': [412], 'is': [413, 724, 1078, 1562, 2266, 2388, 2397, 2641], 'characterized': [414], 'urge': [417], 'move': [419], 'combined': [420], 'occurrence': [423], 'unpleasant': [425, 2604], 'or': [426, 435, 439, 447, 480, 506, 928, 1389, 2289], 'disabling': [427], 'rest.': [431], 'These': [432], 'begin': [434], 'worsen': [436], 'rest': [438], 'inactivity': [440], 'occur': [442], 'mostly': [443], 'evening': [446, 1056, 1211, 2441], 'night.': [448], 'They': [449, 1150], 'relieved': [451], 'voluntary': [453, 1157], 'movement,': [454], 'least': [456], 'long': [458], 'activity': [461, 1538, 1572, 1595], 'continues.1': [462], 'Eighty': [463], '90': [465, 1611], 'percent': [466], 'RLS': [468, 498, 512, 523, 534, 553, 577, 580, 610, 632, 701, 739, 748, 766, 817, 852, 858, 889, 896, 978, 1061, 1099, 1204, 1449, 1789, 1834, 1884, 2176, 2226, 2283, 2295, 2346, 2394, 2433, 2507, 2624, 2649, 2659, 2741], 'also': [470, 720, 1563, 1730, 1870, 2110, 2311], 'suffer': [471, 812, 2655], 'involuntary': [473], 'limb': [475, 1635, 1874, 2862, 2893, 3614], '(PLMW)': [479, 1524, 2900], 'sleep': [481, 923, 1567, 1574, 2896, 3141], '(PLMS).1,2,3Clinical': [482], 'experience': [483, 622, 1063, 3198], 'shows': [484, 623], 'that,': [485], 'besides': [486, 1360], 'movement': [487, 1326, 1373, 1586, 1636, 2863, 3139, 3615], 'legs,': [490, 505], 'may': [496, 510, 630, 703, 2435], 'Cold': [500], 'showers,': [501], 'massaging': [502], 'hot': [508], 'bath': [509], 'lessen': [511], 'symptoms.4': [513], 'One': [514, 1001], 'case': [515], 'showed': [517, 548, 604, 2292, 2341], 'that': [518, 582, 624, 722, 736, 956, 1561, 1581, 1804, 2209, 2270, 2313, 2367, 2380, 2446, 2476, 2533, 2691], 'massage': [520], 'program': [521], 'reduced': [522], 'complaints.5': [524], 'In': [525, 1891, 2671], 'addition,': [526, 2672], 'several': [527], 'studies': [528, 1780, 2299], 'report': [529, 849, 2827], 'positive': [531, 550, 692, 2320, 2343], 'use': [538, 564, 884, 936, 953], 'compression': [541, 567, 698, 728, 2287, 2386, 2959, 2977], 'legs.': [544, 1554], 'Eliasion': [545], 'Lettieri': [547, 2957, 2973], 'improvement': [556, 2392, 2739], 'fatigue': [558], 'daytime': [560], 'sleepiness': [561], 'sequential': [566], 'devices.6,7': [568], 'Moreover,': [569], 'Rajaram': [570, 2992, 3031], 'colleagues': [572], 'reported': [573], 'reduction': [575, 608], 'treated': [584, 1882], 'enhanced': [586, 2329], 'counter': [588, 2331, 3003, 3038], 'pulsation': [589, 2332, 3004, 3039], '(EECP)': [590, 2333, 3005, 3040], 'congestive': [595], 'heart': [596], 'failure.8': [597], 'Nevertheless,': [598, 717], 'follow-up': [600], 'double-blind,': [601], 'placebo-controlled': [602, 2325], 'difference': [606, 1694, 1815, 2545, 2581], 'between': [612, 1109, 1676, 1699, 1711, 1738, 1818, 2052, 2153, 2204, 2551, 2592, 2621, 3161], 'therapeutic': [614, 2337], 'EECP': [615, 2352], 'placebo.9BRIEF': [617], 'SUMMARYCurrent': [618], 'Knowledge/Study': [619], 'Rationale:': [620], 'Clinical': [621, 3557], 'symptoms,': [633, 1790], 'these': [638, 695, 904, 1696, 2024, 2298], 'phenomena': [639], 'lacking.': [641], 'We': [642], 'symptoms.Study': [660], 'Impact:': [661], 'External': [662], 'tends': [665], 'reduce': [667], 'suffering': [672, 1731], 'syndrome.': [676, 2933, 2947, 2967, 2986, 3099, 3121, 3148], 'treatments.The': [691], 'local': [696, 709, 715, 1010], 'devices': [699, 2291, 2366, 2387, 2960, 2978], 'complaints': [702, 2347], 'be': [704, 959, 1809, 2514, 2539, 2602, 2689], 'attributed': [705], 'improved': [708], 'circulation': [710], 'decrease': [712], 'subclinical': [714], 'ischemia.7,8': [716], 'one': [718, 1253, 1461, 2309, 2443, 2473], 'hypothesize': [721], 'it': [723, 2687], 'repetitive': [727, 730], 'but': [729], 'reduces': [737], 'symptoms.To': [740], 'objectify': [741], 'phenomenon': [743], 'reducing': [747], 'complaints,': [749], 'stimulus': [761, 1271, 1288, 1303, 2257, 2609], 'ankle': [764, 2281], 'applied.METHODSParticipantsPatients': [769], 'recruited': [771], 'outpatient': [774], 'clinic': [775], 'both': [777, 2183, 2348], 'Hague': [789], 'St': [795], 'Hospital/Nieuwegein.': [797], 'Patients': [798, 911, 1378], 'had': [799, 810, 847, 1125, 1880], 'meet': [801, 977], 'essential': [803], 'criteria': [804], 'RLS.1': [806], 'Furthermore,': [807], 'all': [808, 1036, 1475, 1649, 1892, 2041, 2424], 'moderate': [814], 'severe': [816, 2648, 2658], 'defined': [819], 'John': [822, 3067], 'Hopkins': [823, 3068], 'Severity': [826], '(JHRLSS,': [828], '≥': [830, 834], '2)10,': [831], '15': [835], 'International': [838, 2910, 3080, 3088], 'Group': [842, 2915, 3093], 'rating': [843, 3094], '(IRLS)11': [845], '6-7': [853], 'days': [854], 'week.': [856], 'Secondary': [857], 'ruled': [860], 'out': [861], 'blood': [863, 867], 'analysis': [864], '(on': [865], 'total': [866, 1510], 'count,': [868], 'iron': [869], 'deficiency,': [870], 'thyroid': [871], 'function,': [872], 'glucose,': [873], 'renal': [874], 'function)': [875], 'physical': [877], 'neurological': [878, 920], 'examination.Patients': [879], 'allowed': [882, 934, 1115], 'any': [885, 918, 1156, 1692, 2662], 'pharmacological': [886], 'treatment': [887, 2963, 3009], 'If': [893, 1169], 'used': [895, 1338, 1443, 1558, 1564, 1887], 'specific': [897], 'drugs,': [898], 'they': [899, 915, 1177], 'asked': [901, 1424], 'stop': [903], '2': [905, 1889, 1898, 2014], 'weeks': [906], 'prior': [907, 1900, 1913], 'excluded': [913, 1004, 1588], 'if': [914, 1689, 2413], 'other': [919, 925], 'disorder': [921], '(including': [922], 'disorders': [924], 'than': [926, 1758, 2019], 'RLS)': [927], 'psychiatric': [929], 'disease;': [930], 'antidepressants.Thirty-six': [937], 'willing': [940], 'participate': [942], 'excluded—4': [949], 'because': [950, 962, 995], 'neuroleptics': [955], 'stopped,': [960], '7': [961, 1511], 'comorbidities': [964], 'like': [965], 'low': [966], 'ferritin': [967], 'levels,': [968], 'diabetes': [969], 'mellitus,': [970], 'hypothyroidism;': [972], '4': [973], 'did': [975, 2576, 2753], 'criteria.': [980], 'Twenty-one': [981], 'included': [984, 2569], 'Two': [988], 'withdrew': [990], 'participation': [992], 'after': [993, 2743], 'inclusion': [994, 2642], 'large': [998], 'travel': [999], 'distance.': [1000], 'patient': [1002, 1223, 1489], 'technical': [1006, 3622], 'reasons': [1007], '(irreproducible': [1008], 'SSEPs).The': [1009], 'ethics': [1011], 'committee': [1012], '(METC': [1013], 'Zuid-West': [1014], 'Holland;07-042)': [1015], 'approved': [1016], 'All': [1019, 1065, 1763, 1852], 'details': [1020, 2102], 'risks': [1022], 'explained': [1027], 'participants': [1030, 2618], 'verbally': [1031], 'writing': [1034], 'gave': [1037], 'written': [1038], 'informed': [1039], 'consent.Study': [1040], 'DesignAll': [1041], 'procedures': [1042], 'Haaglanden.': [1049], 'measurements': [1051, 2192, 2425], 'time': [1059, 1208, 1600, 1708, 2586], 'most': [1060], '(SIT).Suggested': [1073], 'Immobilization': [1074], 'Test': [1075], '(SIT)The': [1076], 'SIT': [1077, 1104, 1124, 1240, 1664, 1675, 1915, 1921, 1933, 2039, 2242, 2412, 2483, 2498, 2518, 2591], 'diagnostic': [1080, 2820], 'tool': [1081], 'developed': [1082, 2901], 'immobility': [1088, 3236], 'motor': [1096, 3240], 'wakefulness.12,13': [1101], 'first': [1103, 2268], 'started': [1105], '8.30': [1107], 'PM;': [1108], 'SITs': [1111, 1238, 2181], 'walk': [1117], 'around': [1118], '10': [1120, 3570], 'minutes.': [1121, 1130, 1438], 'Each': [1122], 'independent': [1123, 1236], 'duration': [1127, 1165, 1285, 1334, 2480, 2500, 2521], '30': [1129, 1666, 1978, 2478], 'During': [1131], 'remained': [1135], 'bed,': [1137], 'reclined': [1138], '45°': [1141], 'angle': [1142], 'their': [1144, 1172, 1181, 1190, 1427], 'extended': [1146], '(see': [1147, 1199], 'picture': [1148], '1).': [1149, 2033], 'instructed': [1152], 'make': [1155, 1796], 'stay': [1160, 1186], 'awake': [1161, 1187], 'entire': [1164], 'test.': [1168], 'closed': [1171], 'eyes': [1173, 1191], 'SIT,': [1176, 1194], 'tapped': [1179], 'arm': [1182], 'reinstructed': [1184], 'keep': [1189], 'open.During': [1192], 'different': [1196, 1420, 1948, 2051, 2155, 2206, 2595], 'below)': [1200], 'performed.': [1202], 'increases': [1206], 'over': [1207, 1224, 1707, 2065, 2074, 2585], 'night,': [1213], 'counterbalanced': [1216, 2462], 'each': [1222, 1663], 'SITs.': [1228, 1530], 'three': [1235, 2179, 2470, 2594], 'were:': [1239], 'without': [1241, 1916], 'stimulation;SIT': [1243], 'posterior': [1249, 1256, 1927, 1940], 'tibial': [1250, 1257, 1536, 1593, 1928, 1941], 'nerve': [1251, 1258, 1323, 1929, 1942], 'leg.': [1254], 'stimulated': [1260], 'adjacent': [1261], 'medial': [1264], 'malleolus.': [1265], 'intensity': [1267, 1304, 2438], 'adjusted': [1273], 'until': [1274, 1504], 'twitch': [1276], 'big': [1279, 1329, 1376], 'toe': [1280], 'seen.': [1282], 'pulse': [1284, 1333], '0.2': [1290], 'ms;': [1291], 'frequency': [1293, 1336], 'Hz.SIT': [1296], 'same': [1302, 1332, 2430], 'stimulator': [1315], 'placed': [1317, 1544], 'little': [1319], 'aside': [1320, 1937], 'prevent': [1325], 'toe.': [1330, 1377], '2.Condition': [1342], 'added': [1345], 'measure': [1347, 1411, 1532, 1570, 2168], 'solely': [1348], 'compared': [1354, 1648, 1710, 1737, 1743], 'effect,': [1364], 'generated': [1370, 2318], 'due': [1371, 2692], 'receive': [1382], 'either': [1386], 'right': [1388, 1551], 'left': [1391, 1553], 'ankle.Simultaneous': [1392], 'somatosensory': [1397], 'evoked': [1398], 'potentials': [1399], '(SSEPs)': [1400], 'ascertain': [1404], 'cortical': [1405], 'processing': [1406], 'stimulus.Leg': [1409], 'DiscomfortTo': [1410], 'degree': [1413], 'SITs,': [1421], 'rate': [1426], '(VAS)': [1435], 'every': [1436, 1501, 1508], '5': [1437, 1502, 1893], 'VAS': [1440, 1494, 1517, 1650, 1657, 1671, 1697, 1706, 1817, 1906, 1975, 2005, 2034, 2235, 2246, 2455, 2550, 2558, 2583, 2698, 2718, 2760], 'has': [1441, 2420], 'been': [1442, 1881, 2568, 2615, 2683], 'before': [1444], 'assess': [1446], 'complaints.14,15': [1450], 'It': [1451, 2612], 'consisted': [1452, 2362], '100': [1455, 1464, 1477], 'mm': [1456, 1470, 1478], 'line': [1457, 2399], 'marked': [1458], '0': [1459, 1469, 1655], 'other,': [1467], 'representing': [1471], 'indicating': [1479], 'worst': [1481, 2454], 'experienced.': [1483], 'message': [1486], 'signaled': [1487], 'complete': [1491], 'scale;': [1493], 'scores': [1495, 1651, 1658, 1698, 1907, 1976, 2006, 2073, 2236, 2509, 2699, 2719, 2761], 'obtained': [1497], 'baseline': [1499, 1653, 1912], 'min': [1503, 1979], 'SIT—in': [1509], 'times.In': [1512], 'addition': [1513], 'scores,': [1518], 'monitored': [1526, 1540], 'To': [1531], 'PLMWs,': [1533, 1733], 'anterior': [1535, 1592], 'muscle': [1537, 1594], 'using': [1541, 1715, 1744, 2182], 'surface': [1542], 'electrodes': [1543], 'lower': [1547, 2011, 2234, 2374, 2717, 2759], 'third': [1548], 'For': [1555, 1728], 'this,': [1556, 2460], 'device': [1560, 2338], 'our': [1566, 1576, 1776, 2263, 2401, 2526, 2557, 2679, 2701], 'laboratory': [1568, 3116], 'outpatients': [1577], '(ambulant': [1578], 'polysomnography).': [1579], 'PLMWs': [1580, 1614, 1639, 2113, 2511], 'occurred': [1582], 'generalized': [1584], 'body': [1585], 'analyses.': [1590], 'recorded': [1597], 'constant': [1601], '0.3': [1603], 's': [1604], 'high-band': [1607], 'filter': [1608], 'setting': [1609], 'Hz.': [1612], 'scored': [1616, 1958, 1968], 'according': [1617, 1961, 1971], 'Official': [1620], 'World': [1621, 2881], 'Association': [1622, 2882], 'Medicine': [1625, 2885, 3275, 3420, 3510, 3532], '(WASM)': [1626, 2886], 'standards': [1627, 2887, 2927], 'recording': [1629, 2889], 'scoring': [1631, 2891, 3217], 'PLMW.16': [1632], 'index': [1637], '([PLMI]': [1638], 'per': [1640, 2127], 'hour': [1641], 'SIT)': [1643, 1984], 'calculated.Statistical': [1645], 'AnalysisPlanned': [1646], 'analyses': [1647, 1764], '(time:': [1654], 'minutes),': [1656], '(time': [1665], 'min)': [1667], 'conditions.': [1679, 1702, 2471, 2597], 'Friedman': [1680, 1746], 'related': [1683, 1749], 'samples': [1684], 'there': [1690, 2229], 'change': [1704], 'linear': [1717], 'mixed': [1718], 'model': [1719], 'including': [1720, 1805], 'interaction': [1722], 'term': [1723], 'time.': [1727], 'PLMIs': [1735], 'samples.': [1750], 'P': [1751, 3475], 'levels': [1752], 'value': [1755], '0.05': [1759], 'considered': [1761], 'significant.': [1762], 'SPSS': [1768], 'version': [1769], '19.Due': [1770], 'lack': [1773, 2638], '(to': [1775], 'best': [1777, 2261], 'knowledge)': [1778], 'previous': [1779], 'able': [1794, 2213, 2540, 2734], 'sample': [1798, 2529], 'size': [1799, 2530], 'calculation.': [1800], 'However,': [1801, 2023, 2228, 2457, 2504, 2751], 'calculated': [1803], 'would': [1808, 2451, 2538], 'sufficient': [1810], 'detect': [1812, 2542], 'standardized': [1814, 2544], '1.0,': [1823], 'power': [1826], '80%': [1828], 'two-sided': [1830], 'α': [1831], '5%.RESULTSEighteen': [1833], 'completed': [1836], 'protocol—10': [1839], 'males': [1840, 2118], '8': [1842, 2120], 'females.': [1843, 2121], 'age': [1845], '50': [1847], 'years': [1848], '(range;': [1849], '31-69': [1850], 'y).': [1851], 'diagnosed': [1855], 'primary': [1857, 3165], 'RLS.': [1858, 3024], 'median': [1860, 1905, 1974, 2123], 'IRLSS': [1861], 'points': [1865], '(range:': [1866], '15-38).': [1867], 'Five': [1878], '(3': [1886], 'pramipexol,': [1888], 'benzodiapines).': [1890], 'patients,': [1894, 2536, 2702], 'medications': [1895], 'stopped': [1897], 'week': [1899], 'study.Leg': [1903], 'DiscomfortThe': [1904], 'additional': [1917, 2564], 'intervention': [1918], '2)': [1931], '3)': [1944], 'significantly': [1947, 2037], '0.21,': [1951], 'Table': [1952, 2032], '1).Table': [1953], '1': [1954, 1964, 1990, 2021], 'Leg': [1955, 1965], 'discomfort,': [1956, 1966], 'VAS,': [1960, 1970], 'conditionTable': [1963], 'conditionThe': [1973], '(the': [1980], 'highest': [1987], '(69.5;': [1991], 'min-max,': [1992, 2001], '6-98)': [1993], 'lowest': [1996], '(46.0;': [2000], '0-98).': [2002], 'sit': [2009], '(58.5)': [2015], '(57.5)': [2018], '(69.5).': [2022], 'differences': [2025, 2150, 2196, 2505], 'increased': [2036], '<': [2045], '0.01),': [2046], 'although': [2047], '>': [2057], '0.05,': [2058], 'Figure': [2059], '1)Figure': [2060], '1:': [2061], '30-minute': [2067], 'test.Median': [2070], '30-min': [2076], '(SIT)': [2080], '3,': [2100, 3281, 3538], 'see': [2103], 'Methods).Download': [2104], 'FigurePeriodic': [2105], 'Limb': [2106], 'Movement': [2107], 'IndexFifteen': [2108], 'SITs—7': [2117], 'PLMW': [2124, 2203], '(min-max)': [2126], '(0-145)': [2131], '1;': [2134], '(0-190)': [2136], '2;': [2139], '(0-228)': [2142], '3.': [2145], 'PLMI': [2152, 2588], '(Friedman': [2157], 'test,': [2158], '0.76).DISCUSSIONWe': [2161], 'subjective': [2184], '(leg': [2185], 'measured': [2187], 'VAS-score)': [2189], 'objective': [2191], '(PLMW).': [2193], 'No': [2194], 'conditions,': [2207], 'meaning': [2208], 'show': [2215, 2452, 2736], 'given': [2224, 2677], 'two': [2250, 3200], 'applied.To': [2259], 'knowledge,': [2264], 'investigated': [2271], 'Massage,': [2285], 'device,': [2288], 'pneumatic': [2290], 'relief': [2293], 'symptoms.6,7,8,9': [2296], 'Though': [2297], 'primarily': [2300], 'refer': [2301], 'vascular': [2304, 3020], 'explanation': [2305, 2600, 2635], 'relief,': [2308], 'argue': [2312, 2475], 'effect.': [2321], 'parallel': [2323, 3051], 'double-blind': [2324], 'study,': [2326], 'studied': [2335], 'RLS,': [2340], 'receiving': [2351], 'therapy': [2353, 2361, 2665, 2943, 2982, 3445], 'placebo': [2357, 2360], 'group.9': [2358], 'identical': [2364], 'sham': [2365], 'inflated': [2369], 'deflated': [2371], 'pressure': [2375, 3317], 'EECP9,': [2378], 'suggesting': [2379], 'responsible': [2389], 'findings': [2402], 'applied.This': [2418], 'limitations.': [2422], 'First,': [2423], 'done': [2427], 'evening.': [2431], 'As': [2432], 'increase': [2436], 'progresses,': [2442], 'might': [2444, 2613, 2654, 2681], 'expect': [2445], 'last': [2448], 'scores.': [2456], 'overcome': [2459], 'Second,': [2472], 'minutes': [2479], 'procedure': [2484], 'too': [2486, 2657], 'short': [2487], 'demonstrate': [2489], 'effects,': [2491], 'original': [2494], 'protocol': [2495], '60': [2502], 'minutes.13': [2503], 'can': [2512], 'already': [2513], 'detected': [2515], 'ten': [2523], 'minutes.17': [2524], 'Finally,': [2525], 'priori': [2528], 'estimation': [2531], 'indicated': [2532, 2800], '(mean': [2546], 'difference/standard': [2547], 'deviation)': [2548], '1.0.': [2555], 'Unfortunately,': [2556], 'data': [2559], 'non-normally': [2561], 'distributed,': [2562], 'should': [2566], 'have': [2567, 2614, 2661, 2682, 2799], 'obtain': [2571], 'intended': [2573], 'power.This': [2574], 'find': [2578, 2754], 'possible': [2599, 2634], 'nature': [2605], 'itself.': [2611], 'difficult': [2616], 'differentiate': [2620], '"real"': [2623], 'stimulus.': [2632, 2750], 'Another': [2633], 'significance': [2640], 'bias,': [2643], 'included.': [2651], 'group': [2653], 'response': [2663], 'based': [2666], 'alone.': [2670], 'localized.': [2685], 'Alternatively,': [2686], 'postulated': [2690], 'non-normal': [2695], 'distribution': [2696], 'undersampled': [2706], 'resulted': [2708], 'detection': [2711], 'trend': [2715, 2757], 'applied.In': [2729], 'conclusion,': [2730], 'appliance': [2745], 'small': [2756], 'input.': [2767], 'since': [2774], 'treatments': [2787], 'RLS.DISCLOSURE': [2789], 'STATEMENTThis': [2790], 'industry': [2794], 'supported': [2795], 'authors': [2798], 'financial': [2802], 'conflicts': [2803], 'interest.REFERENCES1': [2805], 'Allen': [2806, 2877, 3061], 'RP,': [2807, 3062], 'Picchietti': [2808], 'D,': [2809, 3212], 'Hening': [2810, 2923], 'WA,': [2811], 'Trenkwalder': [2812], 'C,': [2813, 2997], 'Walters': [2814, 2998, 3035], 'AS,': [2815, 2999], 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'novel': [3008], '(RLS):': [3014, 3045, 3379], 'preliminary': [3016, 3046], 'neurologic': [3021], 'hypothesis': [3022], '2005;6:101-6,': [3027], '15716213.': [3028], 'Scholar9': [3030], 'Rudzinskiy': [3033], 'P,': [3034], 'ASEnhanced': [3036], 'negative': [3047], 'results': [3048], 'double': [3052], 'blind': [3053], '2006;7:390-1,': [3057], '16713348.': [3058], 'Scholar10': [3060], 'Earley': [3063], 'CJValidation': [3064], 'scale.': [3072], '2001;2:239-42,': [3075], '11311687.': [3076], 'Scholar11': [3078], 'GroupValidation': [3085], '2003;4:121-32,': [3102], '14592342.': [3103], 'Scholar12': [3105], 'Michaud': [3106, 3225], 'Paquet': [3108], 'Lavigne': [3110, 3227], 'G,': [3111, 3228, 3232, 3266, 3411, 3501], 'Desautels': [3112, 3229], 'A,': [3113, 3158, 3230, 3383, 3450], 'JSleep': [3115], 'Eur': [3122], 'Neurol;': [3123], '2002;48:108-13,': [3124], '12187001.': [3125], 'Scholar13': [3127], 'Boucher': [3130], 'S,': [3131], 'Nicolas': [3132], 'Aet': [3133], 'al.Immobilisation': [3134], 'Disord;': [3150, 3247], '1998;13:324-9,': [3151], '9539348.': [3152], 'Scholar14': [3154], 'Aksu': [3155], 'Demirci': [3157], 'Bara-Jimenez': [3159], 'WCorrelation': [3160], 'putative': [3162], 'indicators': [3163], 'severity.': [3169], '2007;8:84-9,': [3172], '16740410.': [3173], 'Scholar15': [3175], 'Hornyak': [3176], 'Sohr': [3178], 'Busse': [3180], 'Mon': [3181], 'behalf': [3182], '604': [3185], '615': [3187], 'GroupsEvaluation': [3189], 'painful': [3191], 'clinical': [3201], 'trials.': [3202], '2011;12:186-9,': [3205], '21256799.': [3206], 'Scholar16': [3208], 'Bonnet': [3209], 'Carley': [3211], 'Carskadon': [3213], 'Met': [3214], 'al.Recording': [3215], 'movements.': [3219], 'Sleep;': [3220], '1993;16:748-59,': [3221], '8165390.': [3222], 'Scholar17': [3224], 'Poirier': [3231], 'JEffects': [3234], 'Syndrome.': [3245], '2002;17:112-5,': [3248], '11835447.': [3249], 'Scholar': [3251], 'Previous': [3252], 'article': [3253, 3255], 'Next': [3254], 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