Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2081337319', 'doi': 'https://doi.org/10.1002/jcb.10738', 'title': 'Antisteroidogenic actions of hydrogen peroxide on rat leydig cells', 'display_name': 'Antisteroidogenic actions of hydrogen peroxide on rat leydig cells', 'publication_year': 2003, 'publication_date': '2003-11-07', 'ids': {'openalex': 'https://openalex.org/W2081337319', 'doi': 'https://doi.org/10.1002/jcb.10738', 'mag': '2081337319', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14635199'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jcb.10738', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.10738', 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.10738', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024316796', 'display_name': 'Shiow‐Chwen Tsai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1296604144', 'display_name': 'Memorial Hospital of South Bend', 'ror': 'https://ror.org/04whfy367', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1296604144']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shiow‐Chwen Tsai', 'raw_affiliation_strings': ['Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, Republic of China.'], 'affiliations': [{'raw_affiliation_string': 'Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, Republic of China.', 'institution_ids': ['https://openalex.org/I1296604144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026727584', 'display_name': 'Chien‐Chen Lu', 'orcid': 'https://orcid.org/0000-0002-2917-0930'}, 'institutions': [{'id': 'https://openalex.org/I4210127821', 'display_name': 'Mackay Junior College of Medicine, Nursing and Management', 'ror': 'https://ror.org/03j9dwf95', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I4210127821']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chien‐Chen Lu', 'raw_affiliation_strings': ['Department of Nursing, Mackay Junior College of Nursing, Taipei, Taiwan, Republic of China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nursing, Mackay Junior College of Nursing, Taipei, Taiwan, Republic of China', 'institution_ids': ['https://openalex.org/I4210127821']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103515623', 'display_name': 'Chiu‐Shuang Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chiu‐Shuang Lin', 'raw_affiliation_strings': ['Dept of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.'], 'affiliations': [{'raw_affiliation_string': 'Dept of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032170703', 'display_name': 'Paulus S. Wang', 'orcid': 'https://orcid.org/0009-0001-4013-907X'}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Paulus S. Wang', 'raw_affiliation_strings': ['Dept of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.'], 'affiliations': [{'raw_affiliation_string': 'Dept of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.', 'institution_ids': ['https://openalex.org/I148366613']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.821, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 68, 'citation_normalized_percentile': {'value': 0.903089, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '90', 'issue': '6', 'first_page': '1276', 'last_page': '1286'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11146', 'display_name': 'Long-Term Effects of Testosterone on Health', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11146', 'display_name': 'Long-Term Effects of Testosterone on Health', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10116', 'display_name': 'Male Reproductive Health', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10529', 'display_name': 'Effects of Stress on Brain Function and Health', 'score': 0.9778, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/oxidative-stress', 'display_name': 'Oxidative Stress', 'score': 0.458245}], 'concepts': [{'id': 'https://openalex.org/C80446465', 'wikidata': 'https://www.wikidata.org/wiki/Q412483', 'display_name': 'Cholesterol side-chain cleavage enzyme', 'level': 4, 'score': 0.9660288}, {'id': 'https://openalex.org/C2780193516', 'wikidata': 'https://www.wikidata.org/wiki/Q412158', 'display_name': 'Pregnenolone', 'level': 4, 'score': 0.90637946}, {'id': 'https://openalex.org/C2779670467', 'wikidata': 'https://www.wikidata.org/wiki/Q24727595', 'display_name': 'Steroidogenic acute regulatory protein', 'level': 4, 'score': 0.8607561}, {'id': 'https://openalex.org/C2777736315', 'wikidata': 'https://www.wikidata.org/wiki/Q636846', 'display_name': 'Leydig cell', 'level': 4, 'score': 0.7235947}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6976204}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.65514624}, {'id': 'https://openalex.org/C2779279991', 'wikidata': 'https://www.wikidata.org/wiki/Q6058681', 'display_name': 'Testosterone (patch)', 'level': 2, 'score': 0.6044835}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5780146}, {'id': 'https://openalex.org/C2779276759', 'wikidata': 'https://www.wikidata.org/wiki/Q412747', 'display_name': 'Forskolin', 'level': 3, 'score': 0.56887335}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.47811168}, {'id': 'https://openalex.org/C2776683971', 'wikidata': 'https://www.wikidata.org/wiki/Q411064', 'display_name': 'Androstenedione', 'level': 4, 'score': 0.4251036}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.37810248}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.37522343}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31462324}, {'id': 'https://openalex.org/C2780902042', 'wikidata': 'https://www.wikidata.org/wiki/Q177911', 'display_name': 'Steroid', 'level': 3, 'score': 0.25815082}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.23318157}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.18142718}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1682742}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.15187332}, {'id': 'https://openalex.org/C2778575703', 'wikidata': 'https://www.wikidata.org/wiki/Q50265477', 'display_name': 'Luteinizing hormone', 'level': 3, 'score': 0.14686555}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.1328094}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.06546301}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002786', 'descriptor_name': 'Cholesterol Side-Chain Cleavage Enzyme', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013196', 'descriptor_name': 'Dihydrotestosterone', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D006861', 'descriptor_name': 'Hydrogen Peroxide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D016877', 'descriptor_name': 'Oxidants', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013094', 'descriptor_name': 'Spermatozoa', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015124', 'descriptor_name': '8-Bromo Cyclic Adenosine Monophosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015124', 'descriptor_name': '8-Bromo Cyclic Adenosine Monophosphate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000735', 'descriptor_name': 'Androstenedione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000735', 'descriptor_name': 'Androstenedione', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002786', 'descriptor_name': 'Cholesterol Side-Chain Cleavage Enzyme', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005576', 'descriptor_name': 'Colforsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005576', 'descriptor_name': 'Colforsin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013196', 'descriptor_name': 'Dihydrotestosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013196', 'descriptor_name': 'Dihydrotestosterone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006861', 'descriptor_name': 'Hydrogen Peroxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006888', 'descriptor_name': 'Hydroxycholesterols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006888', 'descriptor_name': 'Hydroxycholesterols', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016877', 'descriptor_name': 'Oxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011374', 'descriptor_name': 'Progesterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011374', 'descriptor_name': 'Progesterone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013094', 'descriptor_name': 'Spermatozoa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jcb.10738', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.10738', 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14635199', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jcb.10738', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.10738', 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1454462987', 'https://openalex.org/W1555311341', 'https://openalex.org/W1561433308', 'https://openalex.org/W1587832347', 'https://openalex.org/W1610204701', 'https://openalex.org/W1974694850', 'https://openalex.org/W1983662609', 'https://openalex.org/W1985174470', 'https://openalex.org/W1988713440', 'https://openalex.org/W1988966475', 'https://openalex.org/W1992042326', 'https://openalex.org/W1992897439', 'https://openalex.org/W2003420622', 'https://openalex.org/W2009824654', 'https://openalex.org/W2012902499', 'https://openalex.org/W2019471494', 'https://openalex.org/W2023230221', 'https://openalex.org/W2023237286', 'https://openalex.org/W2031091378', 'https://openalex.org/W2055304898', 'https://openalex.org/W2069496628', 'https://openalex.org/W2070579984', 'https://openalex.org/W2076244912', 'https://openalex.org/W2083400348', 'https://openalex.org/W2085377872', 'https://openalex.org/W2093631184', 'https://openalex.org/W2120593960', 'https://openalex.org/W2146892117', 'https://openalex.org/W2147322409', 'https://openalex.org/W2148636696', 'https://openalex.org/W2160848231', 'https://openalex.org/W2172064361', 'https://openalex.org/W2187202028', 'https://openalex.org/W2286538786', 'https://openalex.org/W2569758629', 'https://openalex.org/W4251162699'], 'related_works': ['https://openalex.org/W2182628025', 'https://openalex.org/W2151638627', 'https://openalex.org/W2121661063', 'https://openalex.org/W2109440467', 'https://openalex.org/W2082678435', 'https://openalex.org/W2081337319', 'https://openalex.org/W2039490460', 'https://openalex.org/W2023901889', 'https://openalex.org/W1824549799', 'https://openalex.org/W1565423102'], 'abstract_inverted_index': {'It': [0], 'has': [1], 'been': [2], 'well': [3], 'known': [4], 'that': [5, 89, 173], 'reactive': [6], 'oxygen': [7], 'species': [8], '(ROS)': [9], 'are': [10], 'produced': [11, 22], 'in': [12, 133, 149], 'the': [13, 33, 38, 43, 52, 97, 111, 118, 134, 145, 155], 'steroidogenic': [14, 64], 'pathway': [15], 'and': [16, 45, 63, 82, 99, 189], 'spermatozoa.': [17], 'H2O2,': [18], 'one': [19], 'of': [20, 40, 55, 113, 121, 136, 140, 147, 157, 168], 'ROS': [21], 'by': [23, 164, 185], 'spermatozoa,': [24], 'appears': [25], 'to': [26, 76, 154, 181], 'be': [27], 'a': [28], 'primary': [29, 49], 'toxic': [30], 'agent.': [31], 'In': [32, 110, 152], 'present': [34], 'study,': [35], 'we': [36], 'examined': [37], 'effects': [39], 'H2O2': [41, 90, 103, 122, 128, 160, 174], 'on': [42, 123, 177], 'basal': [44, 98], 'evoked-testosterone': [46], 'release': [47, 125], 'from': [48], 'Leydig': [50, 80, 150, 179], 'cells,': [51], 'protein': [53, 68, 166, 191], 'expressions': [54], 'cytochrome': [56], 'P450': [57], 'side': [58], 'chain': [59], 'cleavage': [60], 'enzyme': [61], '(P450scc)': [62], 'acute': [65], 'regulatory': [66], '(StAR)': [67], 'were': [69], 'also': [70, 129, 161], 'investigated.': [71], 'Our': [72], 'preparation': [73], 'was': [74, 126], 'found': [75], 'contain': [77], 'approximately': [78], '87%': [79], 'cells': [81, 180], 'very': [83], 'few': [84], 'macrophages.': [85], 'The': [86], 'results': [87, 171], 'demonstrated': [88], '(>1': [91], 'x': [92], '10(-4)': [93], 'M)': [94], 'significantly': [95], 'inhibited': [96, 130], 'hCG-stimulated': [100], 'testosterone': [101, 108, 124, 183], 'release.': [102, 109], 'abolished': [104], 'forskolin-': [105], 'or': [106, 116], '8-Br-cAMP-evoked': [107], 'presence': [112, 135], 'pregnenolone,': [114], 'progesterone,': [115], 'androstenedione,': [117], 'inhibitory': [119], 'effect': [120], 'prevented.': [127], 'pregnenolone': [131], 'production': [132, 184], 'trilostane': [137], '(an': [138], 'inhibitor': [139], '3beta-hydroxysteroid': [141], 'dehydrogenase),': [142], 'therefore': [143], 'diminished': [144], 'activity': [146, 188], 'P450scc': [148, 187], 'cells.': [151], 'addition': [153], 'inhibition': [156], 'hormone': [158], 'secretion,': [159], 'regulated': [162], 'steroidogenesis': [163], 'diminishing': [165], 'expression': [167], 'StAR.': [169], 'These': [170], 'suggest': [172], 'acts': [175], 'directly': [176], 'rat': [178], 'diminish': [182], 'inhibiting': [186], 'StAR': [190], 'expression.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2081337319', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-13T23:10:04.256412', 'created_date': '2016-06-24'}