Act1 Adaptor Protein Is an Immediate and Essential Signaling Component of Interleukin-17 Receptor

Name: Work Video:
Duration: 3 min 30 s
Seon Hee Chang; Heon Park; Chen Dong
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'role': [33, 215, 284, 466, 3350], 'in': [34, 38, 44, 115, 167, 190, 194, 216, 244, 285, 289, 295, 366, 418, 441, 445, 467, 495, 524, 836, 841, 925, 1050, 1101, 1156, 1217, 1238, 1279, 1306, 1353, 1424, 1449, 1548, 1627, 1740, 1876, 1907, 1943, 1988, 1997, 2017, 2158, 2186, 2214, 2244, 2253, 2441, 2544, 2630, 2692, 2754, 2770, 2786, 2825, 2961, 3016, 3045, 3104, 3137, 3229, 3290, 3306, 3320, 3334, 3341, 3353, 3369, 3395, 3415, 3490, 3515, 3550, 3570, 3580], 'promoting': [35, 286], 'tissue': [36, 287, 839, 2072], 'inflammation': [37, 288, 516, 840], 'host': [39, 290, 778], 'defense': [40, 291], 'against': [41, 292], 'infection': [42, 293, 781], 'autoimmune': [45, 296, 526, 785, 3582], 'diseases.': [46, 250, 297, 501, 527], 'Although': [47, 298, 1443], 'has': [49, 69, 242, 300, 320, 493, 530, 772, 1204], 'been': [50, 71, 301, 322], 'reported': [51, 131, 302, 382, 1005, 1445, 2862, 3424], 'to': [52, 87, 101, 303, 338, 352, 556, 639, 780, 960, 1189, 1227, 1311, 1383, 1437, 1446, 1579, 1779, 1811, 1839, 1872, 1890, 1918, 1937, 2218, 2289, 2532, 2806, 2815, 2856, 2863, 2918, 2991, 3172, 3198, 3371, 3383, 3445, 3532, 3544, 3553, 3588], 'regulate': [53, 304], 'expression': [55, 306, 555, 638, 1382, 2282, 2291, 2914, 3394], 'proinflammatory': [57, 308, 831, 898, 3560], 'cytokines,': [58, 309], 'chemokines,': [59, 310], 'matrix': [61, 312], 'metalloproteinases,': [62, 313], 'signaling': [64, 140, 232, 315, 391, 483, 1103, 1291, 1451, 2726, 2788, 2839, 3381, 3514, 3542, 3592, 3611, 3622], 'mechanism': [65, 233, 316, 484], 'receptor': [68, 100, 110, 121, 157, 211, 239, 319, 351, 361, 372, 408, 462, 490, 573, 656, 965, 1221, 1231, 1362, 2683], 'not': [70, 145, 223, 321, 396, 474, 1589, 2768, 3028, 3193], 'understood.': [72, 323], 'An': [73, 324], 'earlier': [74, 325], 'study': [75, 222, 326, 473, 3519, 3615], 'found': [76, 327], 'activates': [79, 330, 1042], 'NF-κB': [80, 134, 198, 331, 385, 449, 1043, 1448, 3355, 3384, 3555], 'MAPK': [82, 333], 'pathways': [83, 334, 1317], 'requires': [85, 336], 'TRAF6': [86, 337, 1164, 1235, 1314, 1541, 1546, 2813, 2985, 3014, 3033, 3539], 'induce': [88, 339], 'IL-6.': [89, 340], 'However,': [90, 341, 1261, 3485], 'it': [91, 342, 1003, 1262, 1538, 2744], 'unknown': [93, 344], 'what': [94, 345, 2667], 'molecule(s)': [95, 346], 'directly': [96, 158, 347, 409, 1591, 2507, 2669, 2981, 3145], 'associates': [97, 348, 1592, 3222], 'with': [98, 119, 125, 212, 349, 370, 376, 463, 776, 923, 1012, 1209, 1213, 1295, 1593, 1698, 1745, 1770, 1831, 1846, 1896, 1927, 1977, 2002, 2009, 2042, 2151, 2220, 2227, 2435, 2468, 2481, 2563, 2575, 2582, 2591, 2614, 2636, 2650, 2671, 2688, 2728, 2812, 2849, 2865, 2879, 2895, 2988, 3030, 3042, 3058, 3064, 3073, 3097, 3223, 3273, 3304, 3401], 'initiate': [102, 353, 1289, 3533], 'signaling.': [104, 149, 355, 400, 1581, 2749, 2772, 3231, 3535], 'We': [105, 356, 2773, 2888, 3635], 'demonstrate': [106, 357], 'here': [107, 358], 'family': [111, 238, 362, 489, 813, 973, 1197, 2684, 2694, 3448, 3602], 'shares': [112, 363, 1350, 2724], 'sequence': [113, 364, 1215, 1347, 1689, 2256, 2704], 'homology': [114, 365, 1373, 2687], 'their': [116, 367, 1290, 1307, 3691], 'intracellular': [117, 368], 'region': [118, 369], 'Toll-IL-1': [120, 371, 572, 655], '(TIR)': [122, 373], 'domains': [123, 374, 1374, 2690, 2709], 'Act1,': [126, 377, 1805, 2084, 2858, 3527], 'adaptor': [129, 208, 380, 459, 1297, 1577, 1617, 2738], 'previously': [130, 381], 'as': [132, 175, 177, 205, 383, 426, 428, 456, 709, 739, 829, 1378, 1433, 1482, 1575, 1630, 3408, 3528], 'activator.': [135, 386], 'MyD88': [136, 387, 1305, 2657, 2734, 2766, 2785, 3022], 'IRAK4,': [138, 389, 2779], 'downstream': [139, 234, 390, 485, 1296, 1316, 2739, 2782], 'components': [141, 392], 'TIR,': [143, 394, 571, 654], 'are': [144, 395, 504, 1629, 3586], 'required': [146, 397, 3249, 3378, 3511, 3587], 'for': [147, 225, 398, 476, 1486, 1603, 1619, 1815, 2028, 2031, 2114, 2134, 2211, 2300, 2478, 2497, 2508, 2513, 2541, 2622, 2641, 2660, 2747, 3235, 3250, 3379, 3512, 3642, 3654, 3667, 3681, 3690, 3698], 'On': [150, 401, 2075], 'other': [152, 403, 1094, 1219, 3541, 3597], 'hand,': [153, 404], 'Act1': [154, 166, 188, 204, 405, 417, 439, 455, 1429, 1481, 1535, 1574, 1588, 1785, 1902, 2051, 2846, 2876, 2892, 2902, 2923, 2929, 2965, 2978, 3041, 3069, 3088, 3096, 3169, 3189, 3208, 3220, 3232, 3245, 3260, 3278, 3285, 3352, 3375, 3419, 3482, 3508, 3536, 3549, 3579, 3604], 'associate': [159, 410, 2670, 2894, 2980], 'likely': [160, 411, 3537], 'via': [161, 412, 1186, 1292, 1595, 2885], 'homotypic': [162, 413, 1293, 2886, 3156, 3213], 'interaction.': [163, 414, 2887], 'Deficiency': [164, 415, 3547], 'fibroblast': [168, 419, 557, 640, 1384, 3269], 'abrogates': [169, 420], 'IL-17-induced': [170, 195, 421, 446, 3236], 'chemokine': [173, 424], 'expression,': [174, 425], 'well': [176, 427], 'induction': [179, 217, 430, 468, 1153], 'C/EBPβ,': [181, 432], 'C/EBPδ,': [182, 433, 2363], 'IκBζ.': [184, 435], 'Also,': [185, 436, 3110], 'absence': [186, 437, 3310, 3417], 'results': [189, 201, 440, 452, 1049], 'selective': [192, 443], 'defect': [193, 444, 3487], 'activation': [196, 447, 1312, 3556], 'pathway.': [199, 450], 'These': [200, 451], 'thus': [202, 453, 1376], 'indicate': [203, 454], 'membrane-proximal': [207, 458, 3530], 'essential': [214, 465, 1602, 2737, 2746, 2769], 'inflammatory': [219, 470, 784, 926, 1607, 3392], 'genes.': [220, 471], 'Our': [221, 472], 'only': [224, 475, 1590], 'first': [227, 478, 1613, 2720, 2889], 'time': [228, 479], 'reveals': [229, 480], 'immediate': [231, 482], 'but': [240, 491, 1599, 2653, 3192], 'also': [241, 492, 801, 921, 1422, 1431, 1600, 2867, 3427, 3479, 3616], 'implications': [243, 494], 'therapeutic': [245, 496], 'treatment': [246, 497, 2761, 3081, 3496], 'various': [248, 499, 3402], 'immune': [249, 500, 513], 'Inflammatory': [502], 'reactions': [503], 'complex': [505, 3044, 3593], 'biological': [506], 'processes': [507], 'involving': [508], 'both': [509, 3360], 'innate': [510], 'adaptive': [512], 'systems.': [514], 'Chronic': [515], 'crucially': [518], 'many': [525], 'Recent': [528], 'work': [529], 'identified': [531], 'produce': [540], 'IL-17,': [541, 546, 629, 800, 3059], '3The': [542, 625], 'abbreviations': [543, 626], 'used': [544, 627, 1626, 2506, 2730, 2843, 2917, 3171], 'are:': [545, 628, 2303], 'interleukin': [547, 630], '17;': [548, 631], 'IL-17R,': [549, 632], 'receptor;': [551, 599, 634, 682], 'SEFIR,': [552, 635], 'SEF': [553, 636], '(similar': [554, 637, 1381], 'growth': [558, 587, 641, 670, 1385], 'factor)': [559, 642], 'IL-17R': [561, 644, 972, 1196, 1372, 1418, 1621], 'domain;': [562, 574, 645, 657], 'STIR,': [563, 646], 'domain': [564, 647, 1420, 1803, 1820, 2004, 2882, 2900, 2908, 3116, 3167, 3185, 3191, 3203], 'superfamily': [565, 648, 1367], 'consisting': [566, 649, 1368], 'SEFIR': [568, 651, 1419, 1597, 1802, 2853, 2870, 2899, 3166, 3190, 3217], 'TIR;': [570, 653], 'C/EBP,': [575, 658], 'CCAAT/enhancer': [576, 659], 'binding': [577, 660, 1542, 1944, 2000, 2010], 'protein;': [578, 661], 'IκBα': [579, 662, 3330, 3338, 3368], 'IκBζ,': [581, 664, 3436], 'inhibitors': [582, 665], 'κB;': [584, 667], 'TGF,': [585, 668], 'transforming': [586, 669], 'factor;': [588, 592, 671, 675], 'TNF,': [589, 672], 'tumor': [590, 673], 'necrosis': [591, 674], 'MEF,': [593, 676, 3336, 3656], 'mouse': [594, 677, 1157, 2050, 2711], 'embryonic': [595, 678, 1158], 'fibroblast;': [596, 679], 'TLR,': [597, 680], 'Toll-like': [598, 681, 1192, 1361], 'GST,': [600, 683], 'glutathione': [601, 684], 'S-transferase;': [602, 685], 'HRP,': [603, 686], 'horseradish': [604, 687], 'peroxidase;': [605, 688], 'ELISA,': [606, 689], 'enzyme-linked': [607, 690], 'immunosorbent': [608, 691], 'assay;': [609, 692], 'DMEM,': [610, 693], "Dulbecco's": [611, 694], 'modified': [612, 695], "Eagle's": [613, 696], 'medium;': [614, 697], 'HA,': [615, 698], 'hemagglutinin;': [616, 699], 'shRNA,': [617, 700], 'short': [618, 701], 'hairpin': [619, 702], 'RNA;': [620, 703], 'LPS,': [621, 704], 'lipopolysaccharide;': [622, 705], 'WT,': [623, 706], 'wild-type.': [624, 707], 'named': [708], 'THIL-17,': [710], 'TH17,': [711], 'or': [712, 1655, 1837, 2512, 2982, 3309, 3492], 'THi': [713], '(1Dong': [715, 787, 814, 906], 'C.': [716, 788, 815, 864, 907, 1115, 1553], 'Nat.': [717, 789, 816, 865, 908], 'Rev.': [718, 790, 817, 909], 'Immunol.': [719, 791, 818, 866, 910, 1032, 1121, 2948], '2006;': [720, 755, 792, 819, 911, 1033, 1325, 2796, 2949], '6:': [721, 793, 820, 868, 912], '329-334Crossref': [722, 794, 821, 913], 'PubMed': [723, 763, 795, 822, 870, 914, 953, 997, 1036, 1071, 1088, 1125, 1143, 1177, 1256, 1328, 1413, 1470, 1526, 1563, 2799, 2952, 3007, 3469], 'Scopus': [724, 764, 796, 823, 871, 915, 954, 998, 1037, 1072, 1089, 1126, 1144, 1178, 1257, 1329, 1414, 1471, 1527, 1564, 2800, 2953, 3008, 3470], '(435)': [725, 797, 824, 916], 'Google': [726, 766, 798, 825, 873, 917, 956, 1000, 1039, 1074, 1091, 1128, 1146, 1180, 1259, 1331, 1416, 1473, 1529, 1566, 2802, 2955, 3010, 3472], 'Scholar).': [727, 767, 799, 826, 874, 918, 957, 1001, 1040, 1147, 1181, 1260, 1332, 1417, 1530, 1567, 2803, 3473], 'cell': [729, 1491, 1979, 2062, 2442, 2610, 3055], 'differentiation': [730], 'into': [731, 1788, 1829, 2913], 'these': [732, 774, 3132, 3476, 3569], 'cytokines': [737, 880, 1771, 3561], 'such': [738, 3407], 'IL-23': [743], '(2Weaver': [744], 'C.T.': [745], 'Harrington': [746], 'L.E.': [747], 'Mangan': [748], 'P.R.': [749], 'Gavrieli': [750], 'M.': [751, 1019, 1059, 1393, 1500, 1512, 1551], 'Murphy': [752], 'K.M.': [753], 'Immunity.': [754, 990, 1517], '24:': [756], '677-688Abstract': [757], 'Full': [758, 760, 948, 950, 994, 1066, 1068, 1408, 1410, 1521, 1523], 'Text': [759, 761, 949, 951, 995, 1067, 1069, 1409, 1411, 1522, 1524], 'PDF': [762, 952, 996, 1070, 1412, 1525], '(1161)': [765], 'More': [768], 'more': [770, 3047], 'evidence': [771], 'associated': [773, 3072, 3174], 'normal': [777], 'responses': [779], 'abnormal': [783], 'diseases': [786], 'called': [802], 'IL-17A,': [803], 'family-IL-17': [812], 'Widely': [827], 'regarded': [828], 'cytokine,': [832], 'crucial': [835, 2781], 'regulation': [837, 927, 1605], 'vivo': [842], '(3Park': [843], 'H.': [844, 935, 1557], 'Li': [845, 1458, 1515, 3672], 'Z.': [846, 860, 975, 1081, 1170, 1249, 1455, 1457, 3000], 'Yang': [847], 'X.O.': [848], 'Chang': [849], 'S.H.': [850], 'Nurieva': [851], 'R.': [852, 1077, 1119, 1166, 1245, 2996], 'Wang': [853, 855], 'Y.H.': [854], 'Y.': [856, 1107, 1453, 1494, 1555], 'Hood': [857], 'L.': [858, 2936], 'Zhu': [859], 'Tian': [861], 'Q.': [862], 'Dong': [863, 3696], '2005;': [867, 3466], '1133-1141Crossref': [869], '(3419)': [872], 'regulates': [876], 'production': [878, 2822, 3314], '(IL-6,': [881], 'TNF-α,': [882, 3312, 3497], 'IL-1β),': [884], 'chemokines': [885, 3406, 3563], '(RANTES,': [886], 'MCP-1,': [887, 2304], 'MIP-2/IL-8,': [888], 'MIP-3α,': [889], 'GROα),': [891], 'cell-surface': [892], 'markers': [893], '(RANKL': [894], 'ICAM-1)': [896], 'mediators': [899], '(prostaglandin': [900], 'E2,': [901], 'nitric': [902], 'oxide,': [903], 'cyclooxygenase-2)': [905], 'Moreover,': [919], 'synergizes': [922], 'TNF-α': [924, 1674, 3372], '(4Ruddy': [928], 'M.J.': [929, 3458], 'Wong': [930], 'G.C.': [931], 'Liu': [932, 3675], 'X.K.': [933], 'Yamamoto': [934], 'Kasayama': [936], 'S.': [937, 1111, 1321, 1465, 2792], 'Kirkwood': [938], 'K.L.': [939], 'Gaffen': [940, 1855, 2945, 3461, 3659], 'S.L.': [941, 983, 2946, 3462], 'J.': [942, 1024, 1026, 1028, 1030, 1031, 1057, 1060, 1082, 1120, 1171, 1250, 1397, 1496, 2947, 3001, 3463], 'Biol.': [943, 1061, 3465], 'Chem.': [944, 1062], '2004;': [945, 1122, 1518], '279:': [946], '2559-2567Abstract': [947], '(288)': [955], 'binds': [959], 'signals': [962], 'through': [963, 2139, 2525, 2851], 'A': [966, 1270, 1365, 1531, 3126, 3268], '(IL-17RA),': [967], '(5Yao': [974], 'Fanslow': [976], 'W.C.': [977], 'Seldin': [978], 'M.F.': [979], 'Rousseau': [980], 'A.M.': [981], 'Painter': [982], 'Comeau': [984], 'M.R.': [985], 'Cohen': [986], 'J.I.': [987], 'Spriggs': [988], 'M.K.': [989], '1995;': [991], '3:': [992], '811-821Abstract': [993], '(796)': [999], 'Recently,': [1002], 'was': [1004, 1149, 1375, 1682, 1703, 1713, 1732, 1777, 1786, 1792, 1809, 1826, 1850, 1870, 1905, 1974, 1995, 2054, 2068, 2103, 2120, 2167, 2225, 2238, 2268, 2287, 2523, 2580, 2589, 2698, 2751, 2823, 2966, 2986, 3027, 3062, 3076, 3101, 3119, 3170, 3196, 3271, 3286, 3315, 3332, 3339, 3423, 3488], 'IL-17RA': [1007, 1203, 1233, 1572, 1594, 1648, 1845, 2647, 2723, 2834, 2850, 2884, 2910, 2932, 2976, 3031, 3043, 3061, 3090, 3118, 3201, 3210, 3224, 3230, 3247, 3380, 3522, 3545, 3591, 3601], 'might': [1008], 'form': [1009, 3091, 3135, 3212], 'heterodimer': [1011], 'IL-17RC': [1013], '(6Toy': [1014], 'D.': [1015, 1017], 'Kugler': [1016], 'Wolfson': [1018], 'Vanden': [1020], 'Bos': [1021], 'T.': [1022, 1055, 1319, 2790, 2944], 'Gurgel': [1023], 'Derry': [1025], 'Tocker': [1027], 'Peschon': [1029], '177:': [1034], '36-39Crossref': [1035], '(452)': [1038], 'MAP': [1045], 'kinase': [1046, 1439], 'pathways,': [1047], 'which': [1048, 2809, 3075], 'up-regulation': [1051], 'IL-6': [1053, 1152, 1664, 2661, 2750, 2821, 3313], '(7Shalom-Barak': [1054], 'Quach': [1056], 'Lotz': [1058], '1998;': [1063], '273:': [1064], '27467-27473Abstract': [1065], '(345)': [1073], 'Scholar,': [1075, 1129], '8Schwandner': [1076], 'Yamaguchi': [1078, 1167, 1246, 2997], 'K.': [1079, 1168, 1247, 2998], 'Cao': [1080, 1169, 1248, 2999], 'Exp.': [1083, 1172, 1251, 3002], 'Med.': [1084, 1173, 1252, 3003], '2000;': [1085, 1174, 1253, 3004], '191:': [1086, 1175, 1254, 3005], '1233-1240Crossref': [1087, 1176, 1255, 3006], '(282)': [1090, 1179, 1258, 3009], 'Scholar),': [1092, 1474, 3011], 'although': [1093], 'reports': [1095], 'have': [1096], 'suggested': [1097, 1337, 1480, 2676], 'JAK/STAT': [1098], 'pathway': [1099, 3356, 3608], 'involved': [1100, 3228], '(9Kao': [1104], 'C.Y.': [1105], 'Chen': [1106], 'Thai': [1108], 'P.': [1109, 3460], 'Wachi': [1110], 'Huang': [1112], 'F.': [1113, 1401, 2938, 3456], 'Kim': [1114], 'Harper': [1116], 'R.W.': [1117], 'Wu': [1118], '173:': [1123], '3482-3491Crossref': [1124], '(348)': [1127], '10Subramaniam': [1130], 'S.V.': [1131], 'Cooper': [1132], 'R.S.': [1133], 'Adunyah': [1134], 'S.E.': [1135], 'Biochem.': [1136, 1403], 'Biophys.': [1137], 'Res.': [1138], 'Commun.': [1139], '1999;': [1140], '262:': [1141], '14-19Crossref': [1142], '(98)': [1145], 'It': [1148, 3422], 'shown': [1150], 'fibroblasts': [1159, 3551], '(MEFs)': [1160], 'dependent': [1162], 'on': [1163, 1477, 1615, 1796, 2070, 2169, 2666, 2706, 3481, 3568], '(8Schwandner': [1165, 1244, 2995], 'Thus,': [1182, 2718], 'may': [1184, 2835, 2877, 2979, 3226, 3624], 'signal': [1185, 1199, 1308, 2579], 'mechanisms': [1187], 'similar': [1188, 1351, 2990], 'IL-1': [1190, 1283, 1302], 'receptors': [1193, 1198, 1287, 1303, 1343], '(TLRs).': [1194], 'How': [1195], 'remain': [1200], 'largely': [1201], 'unknown.': [1202], 'long': [1206], 'cytoplasmic': [1207, 1426, 2860, 2881, 2907, 3115, 3184, 3202], 'tail': [1208], '∼500': [1210], 'amino': [1211, 1806, 1823], 'acids': [1212, 1807, 1824], 'no': [1214, 2663, 3486], 'conserved': [1216, 1346, 1358], 'any': [1218], 'families,': [1222], 'suggesting': [1223, 2974, 3012], 'they': [1225, 3143], 'belong': [1226], 'unique': [1229], 'family.': [1232, 1622], 'overexpression': [1236], 'resulted': [1237], 'co-immunoprecipitation': [1239], 'two': [1242, 1354], 'molecules': [1243, 2668], 'unclear': [1264], 'whether': [1265, 2722, 2891, 3087, 3149, 3241, 3259, 3596, 3606], 'association': [1267, 1547, 2921, 3039, 3136, 3214], 'direct.': [1269], 'consensus': [1271], 'TRAF6-binding': [1272], 'motif,': [1273], 'PXEXXZ(X,': [1274], 'aromatic/acidic': [1275], 'residue),': [1276], 'absent': [1278], 'IL-17RA.': [1280, 2006, 2896, 2925, 3187], 'Notably,': [1281], 'TLRs,': [1282, 2742], 'receptors,': [1284], 'TNF': [1286], 'all': [1288, 1339, 3365], 'interaction': [1294, 3151, 3243], 'proteins.': [1298], 'Many': [1299], 'TLRs': [1300, 2713], 'utilize': [1304, 2836, 3603], 'transduction': [1309], 'leading': [1310, 2814, 3382], '(11Kawai': [1318, 2789], 'Akira': [1320, 2791], 'Cell': [1322, 1701, 2040, 2427, 2485, 2793], 'Death': [1323, 2794], 'Differ.': [1324, 2795], '13:': [1326, 2797], '816-825Crossref': [1327, 2798], '(1548)': [1330, 2801], 'Interestingly,': [1333, 2984], 'one': [1334, 1425], 'article': [1335, 2675], 'recently': [1336], 'isoforms': [1340], 'contained': [1344], 'segment': [1348], 'residues': [1352], 'out': [1355], 'three': [1357, 2627], 'motifs': [1359], '(TIR)/IL-1R': [1363], 'domain.': [1364, 2871, 3218], 'new': [1366], 'TIR': [1370, 2651, 2689], 'proposed': [1377], 'STIR': [1379, 2708], '(SEFIR': [1380], 'factor': [1386, 3531], 'genes': [1387], 'IL-17Rs)': [1389], 'TIR)': [1391], '(12Novatchkova': [1392], 'Leibbrandt': [1394], 'A.': [1395, 1399, 1466, 2940], 'Werzowa': [1396], 'Neubuser': [1398], 'Eisenhaber': [1400], 'Trends': [1402], 'Sci.': [1404, 1463], '2003;': [1405], '28:': [1406], '226-229Abstract': [1407], '(196)': [1415], 'observed': [1423, 3489], 'protein,': [1427], 'Act1.': [1428, 1800, 3301], 'known': [1432], 'CIKS,': [1434], 'connection': [1436], 'IκB': [1438, 3447], 'stress-activated': [1441], 'kinase.': [1442], 'initially': [1444], 'activate': [1447], 'CD40-mediated': [1450], '(13Qian': [1452], 'Zhao': [1454], 'Jiang': [1456], 'X.': [1459, 1516, 2942], 'Proc.': [1460], 'Natl.': [1461], 'Acad.': [1462], 'U.': [1464], '2002;': [1467, 1560], '99:': [1468], '9386-9391Crossref': [1469], '(51)': [1472], 'analysis': [1476, 2511, 2705], 'Act1-deficient': [1478, 3398], 'mice': [1479], 'negative': [1484], 'regulator': [1485], 'CD40-': [1487], 'BAFF-induced': [1489], 'B': [1490], 'survival': [1492], '(14Qian': [1493], 'Qin': [1495], 'Cui': [1497], 'G.': [1498], 'Naramura': [1499], 'Snow': [1501], 'E.C.': [1502], 'Ware': [1503], 'C.F.': [1504], 'Fairchild': [1505], 'R.L.': [1506], 'Omori': [1507], 'S.A.': [1508], 'Rickert': [1509], 'R.C.': [1510], 'Scott': [1511], 'Kotzin': [1513], 'B.L.': [1514], '21:': [1519], '575-587Abstract': [1520], '(125)': [1528], 'striking': [1532], 'feature': [1533], 'contains': [1539, 2868], 'motif': [1543, 1598], 'exhibited': [1545], 'vitro': [1549, 1877, 1989, 3105, 3138, 3571], '(15Kanamori': [1550], 'Kai': [1552], 'Hayashizaki': [1554], 'Suzuki': [1556], 'FEBS': [1558], 'Lett.': [1559], '532:': [1561], '241-246Crossref': [1562], '(37)': [1565], 'Therefore,': [1568, 2830, 2872, 3219], 'we': [1569, 1585, 2719, 2831, 2873, 3050, 3239, 3257, 3390, 3574], 'hypothesize': [1570], 'employs': [1573], 'its': [1576, 2816], 'protein': [1578, 1618, 1904, 1935, 1973, 2345, 2522, 2861, 3070, 3163, 3331, 3440], 'transduce': [1580], 'In': [1582, 1863, 1983, 3020, 3325, 3434], 'this': [1583, 3150, 3388, 3614], 'paper,': [1584], 'show': [1586], 'gene': [1608, 2286, 3252, 3393], 'expression.': [1609, 3253], 'This': [1610, 2696], 'report': [1614, 2994], 'Cytokines': [1623], 'Antibodies—Antibodies': [1625], 'experiments': [1628], 'follows:': [1631], 'anti-FLAG-M2': [1632], '(Sigma),': [1633], 'anti-HA.11': [1634], '(Covance);': [1635], 'anti-GST': [1636], '(BD': [1637], 'Biosciences);': [1638], 'anti-Act1': [1639], 'H-300,': [1640], 'anti-IκBα,': [1641], 'anti-TRAF6': [1642], 'H-274': [1643], '(Santa': [1644], 'Cruz': [1645], 'Biotechnology);': [1646], 'anti-human': [1647], '(R&D': [1649], 'Systems);': [1650], 'HRP-conjugated': [1652, 2566], 'goat': [1653], 'anti-mouse': [1654], 'anti-rabbit': [1656], 'secondary': [1657], 'antibodies': [1658, 1666, 2568], '(Jackson': [1659], 'ImmunoResearch': [1660], 'GE': [1662], 'Healthcare).': [1663], 'ELISA': [1665], 'were': [1667, 1675, 1693, 1760, 1768, 1883, 1888, 1925, 2015, 2034, 2095, 2112, 2149, 2178, 2191, 2198, 2209, 2432, 2473, 2490, 2505, 2539, 2569, 2573, 2612, 2634, 2911, 2958, 3412], 'obtained': [1668, 1676, 1683, 1733, 1851, 2192], 'from': [1669, 1677, 1684, 1705, 1734, 1852, 2056, 2154, 2270, 2710, 2841, 3123, 3176, 3685], 'BD': [1670, 1678], 'Biosciences.': [1671], 'IL-1β': [1672], 'Biosciences,': [1679], 'R&D': [1685], 'Systems.': [1686], 'Phylogeny': [1687], 'Analysis—Multiple': [1688], 'alignment': [1690], 'tree-building': [1692], 'performed': [1694, 1926], 'using': [1695, 1707, 2232, 2247, 2275, 2293, 2598], 'Bonsai': [1696], '1.1.6': [1697], 'default': [1699], 'settings.': [1700], 'Culture—MEF': [1702], 'derived': [1704], 'C57BL6': [1706], 'standard': [1709, 2272, 2294], 'protocol.': [1710, 1921], 'MyD88–/–': [1711, 2757], 'MEF': [1712, 1723, 2758, 2827, 3322, 3343, 3364, 3399, 3688], 'provided': [1714], 'Dr.': [1716, 1725, 1853, 3637, 3648, 3657], 'Ruslan': [1717, 3638], 'Medzhitov': [1718, 3639], '(Yale': [1719, 3640], 'University)': [1720, 3641], 'IRAK4–/–': [1722, 2826, 3655], 'Wen-Chen': [1726, 3649], 'Yeh': [1727, 3650], '(University': [1728, 3651], 'Toronto).': [1730], 'A549': [1731], 'ATCC': [1735], '(Manassas,': [1736], 'VA)': [1737], 'grown': [1739], 'high': [1741], 'glucose': [1742], 'DMEM': [1743, 2216], 'supplemented': [1744, 2467], '10%': [1746, 1961, 2025, 2526], 'fetal': [1747], 'bovine': [1748, 1968], 'serum': [1749, 1969], '(Atlanta': [1750], 'Biologicals).': [1751], 'For': [1752, 2515, 2606], 'measurement': [1753], '4': [1756, 1954, 2212, 2476, 2501], '×': [1757, 2066, 2132, 2495], '104': [1758], 'plated': [1761, 2069, 2199], 'onto': [1762, 1913, 2023, 2200], '24-well': [1763], 'plates.': [1764, 2074], 'Next': [1765], 'day,': [1766, 2078], 'treated': [1769, 2210, 3051, 3400], 'overnight,': [1772], 'culture': [1775, 2073, 2152], 'supernatant': [1776], 'subjected': [1778], 'ELISA.': [1780], 'Plasmids—The': [1781], 'full': [1782, 1842], 'length': [1783, 1843], 'cloned': [1787, 1828], 'pcDNA3.': [1789], 'HA': [1790, 1835, 1897, 3099], 'tag': [1791, 1836, 1849, 3100], 'added': [1793], 'PCR': [1795, 2243, 2302], 'N': [1797, 1833], 'terminus': [1798, 1834], 'The': [1801, 1841, 2060, 2101, 2165, 2207, 2260, 2281, 2297, 2471, 2537], '336–555,': [1808], 'inserted': [1810, 1838], 'pGEX4T-1': [1812], '(Amersham': [1813], 'Biosciences)': [1814], 'GST': [1816, 1899, 1922, 1972, 3111, 3127, 3161, 3194], 'fusion': [1817, 1903, 3112, 3162], 'protein.': [1818], 'Cytoplasmic': [1819], 'IL-17RA,': [1822, 2672, 2857, 3074], '346–864,': [1825], 'either': [1827], 'pcDNA': [1830], 'pGEX4T-1.': [1840], 'FLAG': [1848, 2618, 2970], 'Sarah': [1854, 3658], '(State': [1856, 3660], 'University': [1857, 3661], 'New': [1859, 3663], 'York,': [1860, 3664], 'Buffalo,': [1861, 3665], 'NY).': [1862], 'Vitro': [1864], 'Transcription': [1865], 'Translation—Plasmids': [1867], 'encoding': [1868, 2049], 'HA-Act1': [1869], 'subject': [1871], 'T7': [1873], 'Quick': [1874], 'Coupled': [1875], 'transcription': [1878, 1990, 3106, 3429], 'translation': [1880, 1992, 3108], '(Promega).': [1881, 2585], 'Samples': [1882], 'separated': [1884], 'SDS-PAGE;': [1886], 'gels': [1887, 2528], 'transferred': [1889], 'polyvinylidene': [1891, 2533], 'difluoride': [1892, 2534], 'membrane': [1893], 'blotted': [1895], 'antibody.': [1898, 3067], 'Pulldown': [1900], 'Assays—GST-SEFIR': [1901], 'expressed': [1906, 2960, 3120, 3160], 'BL21(DE3)': [1908], '(Promega)': [1910], 'affinity-purified': [1912], 'glutathione-Sepharose': [1914, 1938], '4B': [1915, 1939], 'beads': [1916, 1940, 2014], 'according': [1917], "manufacturer's": [1920], 'pulldown': [1923, 3128], 'assays': [1924], 'total': [1929, 2521], '2': [1931, 1966], 'μg': [1932, 2080, 2086, 2519], 'GST-Act1': [1934], 'bound': [1936, 2032], 'equilibrated': [1942], 'buffer': [1945, 2001, 2011, 2020, 2444, 2640], '(20': [1946], 'mm': [1947, 1952, 1955, 1959, 2446, 2451, 2457, 2460, 2464, 2549, 2554], 'Tris-HCl,': [1948, 2550], 'pH': [1949, 2448, 2551], '7.9,': [1950], '150': [1951], 'KCl,': [1953], 'MgCl2,1mm': [1956], 'EDTA,': [1957, 2452], '1': [1958, 2459, 2463, 2542], 'dithiothreitol,': [1960], 'glycerol,': [1962], '0.1%': [1963, 2556], 'Nonidet': [1964], 'P-40,': [1965], 'mg/ml': [1967], 'albumin).': [1970], 'Bound': [1971], 'then': [1975, 2121], 'incubated': [1976, 1996, 2474, 2613], '293T': [1978, 2064], 'lysates': [1980, 2611, 3177], 'expressing': [1981, 3181, 3277, 3292], 'HA-IL-17RA.': [1982], 'another': [1984, 2115], 'experiment,': [1985], '10': [1986, 2085, 2498], 'μlof': [1987], 'product,': [1993], 'HA-Act1,': [1994], 'same': [1999, 3018, 3025], 'GST-cytoplasmic': [2003], 'After': [2007], 'washing': [2008], 'five': [2012], 'times,': [2013], 'resuspended': [2016], 'SDS-PAGE': [2018, 2026], 'sample': [2019, 2267, 2639], 'loaded': [2022], 'gel': [2027, 2621], 'electrophoresis.': [2029], 'Bands': [2030], 'proteins': [2033, 2957, 3133, 3175], 'visualized': [2035], 'autoradiography.': [2037], 'Transduction': [2038], 'Lines': [2041], 'shRNA': [2043, 2053, 3293], 'Act1—A': [2045], 'retroviral': [2046, 3275], 'construct,': [2047, 3669], 'pSM2c,': [2048], 'microRNA-adapted': [2052], 'purchased': [2055], 'Openbiosystems': [2057], '(Huntsville,': [2058], 'AL).': [2059], 'packaging': [2061], 'line': [2063, 3270], '(5': [2065], '106)': [2067], '100-mm': [2071], 'following': [2077, 2171], '14': [2079], 'pSM2c-shRNA': [2083], 'Gag/pol': [2088], 'plasmid': [2089, 2093], 'DNA': [2090, 2094, 2224], 'VSVg': [2092], 'co-transfected': [2096], 'calcium': [2098], 'phosphate': [2099], 'method.': [2100, 2296], 'medium': [2102, 2119, 2166], 'changed': [2104, 2168], '12': [2105], 'h': [2106, 2213, 2543], 'after': [2107, 2175, 3079, 3495], 'transfection,': [2108], 'cultured': [2113], '48': [2116], 'h.': [2117], 'Conditioned': [2118], 'collected': [2122], 'cleared': [2124, 2609], 'debris': [2126, 2486], 'low': [2128], 'speed': [2129], 'centrifugation': [2130, 2493], '(2,500': [2131], 'g': [2133], '5': [2135, 2450, 2642], 'min)': [2136], 'filtered': [2138], '0.45-μm': [2141], 'filter': [2142], 'stored': [2144], 'at': [2145, 2182, 2193, 2203, 2475, 2500, 2644], '–70': [2146], '°C.': [2147, 2502, 2646], 'MEFs': [2148], 'infected': [2150], 'fluid': [2153], 'virus-producing': [2156], 'presence': [2160, 3308], '8': [2162], 'μg/ml': [2163], 'polybrene.': [2164], 'day.': [2172], 'Two': [2173], 'days': [2174], 'infection,': [2176], 'trypsinized': [2179], 'replated': [2181], '1:3': [2184], 'dilution': [2185], 'puromycin': [2187], 'medium.': [2188], 'Stable': [2189], 'transfectants': [2190], '1–2': [2194], 'weeks.': [2195], 'Real-time': [2196], 'PCR—MEFs': [2197], '6-well': [2201], 'plates': [2202], 'density': [2204], '105/well.': [2206], 'serum-free': [2215], 'prior': [2217], 'stimulation': [2219], 'indicated': [2222], 'cytokines.': [2223, 3403], 'synthesized': [2226], 'RNA': [2228, 3683], 'prepared': [2229], 'TRIzol': [2231], 'RNase': [2233], 'H-reverse': [2234], 'transcriptase': [2235], '(Invitrogen).': [2236], 'cDNA': [2237, 2266], 'analyzed': [2239, 2590], 'real-time': [2241, 2301], 'quantitative': [2242], 'triplicates': [2245], 'iQ': [2248], 'CYBR': [2249], 'Green': [2250], 'Supermix': [2251], '(Bio-Rad)': [2252], 'iCycler': [2255, 2277], 'detection': [2257], 'system': [2258], '(Bio-Rad).': [2259], 'starting': [2261], 'quantity': [2262], 'initial': [2265], 'calculated': [2269], 'primer-specific': [2271], 'curves': [2273], 'Data': [2278], 'Analysis': [2279, 2603], 'Software.': [2280], 'level': [2283, 2292, 3328], 'each': [2285], 'normalized': [2288], 'actin': [2290], 'curve': [2295], 'primer': [2298], 'sets': [2299], 'CTC': [2305, 2325, 2341, 2342], 'AGC': [2306, 2331, 2340], 'CAG': [2307, 2309, 2411], 'ATG': [2308], 'TTA': [2310], 'ACG': [2311, 2350], 'CCC': [2312], '(forward)': [2313, 2333, 2354, 2371, 2398, 2417], 'GGT': [2315], 'GCT': [2316, 2328, 2329, 2374, 2421], 'GAA': [2317, 2400], 'GAC': [2318, 2409], 'CTT': [2319], 'AGG': [2320, 2419], 'GCA': [2321, 2403], 'GAT': [2322], '(reverse);': [2323, 2343, 2362, 2407], 'MCP-3,': [2324], 'ATA': [2326], 'GCC': [2327, 2373], 'TTC': [2330], 'ATC': [2332, 2401, 2413], 'GTC': [2335, 2405, 2412], 'TAA': [2336], 'GTA': [2337, 2366], 'TGC': [2338, 2364], 'TAT': [2339], 'CCAAT/enhancer-binding': [2344], 'β': [2346], '(C/EBPβ),': [2347], 'CGC': [2348, 2395, 2397], 'ACC': [2349], 'ACT': [2351, 2414], 'TCC': [2352], 'TCT': [2353], 'CGA': [2356, 2367, 2368, 2369], 'GGC': [2357, 2410], 'TCA': [2358], 'CGT': [2359, 2361], 'AAC': [2360], 'CAT': [2365, 2393], 'G': [2370, 2416], 'TTG': [2375, 2377], 'TGG': [2376], 'CTG': [2378, 2402, 2404], '(reverse),': [2379], 'molecule': [2380, 2783], 'possessing': [2381], 'ankyrin': [2382], 'repeats': [2383], 'induced': [2384, 3452], 'lipopolysaccharide': [2386], '(LPS;': [2387], 'MAIL)/inhibitor': [2388], 'κBζ': [2390], '(IκBζ),': [2391], 'TGA': [2392], 'CAC': [2394], 'AAA': [2396, 2423], 'TC': [2406], 'β-actin;': [2408], 'ATT': [2415], 'AAG': [2420], 'GGA': [2422], 'GAG': [2424], 'CC': [2425], '(reverse).': [2426], 'Lysis,': [2428], 'Immunoblotting,': [2429], 'Immunoprecipitation—Cells': [2431], 'washed': [2433, 2574], 'once': [2434], 'ice-cold': [2436], 'phosphate-buffered': [2437], 'saline': [2438], 'lysed': [2440], 'lysis': [2443, 2483, 2631], '(50': [2445], 'Tris,': [2447], '8.0,': [2449, 2552], '1%': [2453], 'Triton': [2454], 'X-100,': [2455], '100': [2456, 2645], 'NaCl,': [2458, 2555], 'sodium': [2461], 'orthovanadate,': [2462], 'phenylmethylsulfonyl': [2465], 'fluoride)': [2466], 'protease': [2469], 'inhibitors.': [2470], '°C': [2477], '30': [2479], 'min': [2480, 2499, 2624, 2643], 'buffer.': [2484, 2632], 'unbroken': [2488], 'pelleted': [2491], '(15,000': [2494], 'g)': [2496], 'Supernatant': [2503], 'fractions': [2504], 'Western': [2509, 2516, 3283], 'blot': [2510], 'immunoprecipitation.': [2514], 'blots,': [2517], '50–100': [2518], 'electrophoresed': [2524], 'SDS-polyacrylamide': [2527], 'followed': [2529, 2559, 2625], 'transfer': [2531], '(Millipore)': [2535], 'membranes.': [2536], 'membranes': [2538, 2572], 'blocked': [2540], '5%': [2545], 'milk,': [2546], 'TBST': [2547], '(25': [2548], '125': [2553], 'Tween': [2557], '20)': [2558], 'overnight': [2561], 'incubation': [2562], 'primary': [2564, 2567], 'antibodies.': [2565], 'removed,': [2570], 'TBST,': [2576], 'detected': [2581], 'ECL': [2583], 'reagent': [2584], 'Densitometry': [2586], '(for': [2587], 'signal-density)': [2588], 'EpiChemi3': [2593], 'Darkroom™': [2594], '(UVP': [2595], 'Bioimaging': [2596], 'Systems)': [2597], 'Labworks': [2599], 'Image': [2600], 'Acquisition': [2601], 'Software': [2604], '4.5.': [2605], 'immunoprecipitation': [2607], 'experiments,': [2608], '50': [2615], 'μl': [2616], 'M2-agarose': [2619], 'affinity': [2620], '90': [2623], '5-min': [2628], 'washes': [2629], 'Immunoprecipitates': [2633], 'denatured': [2635], '1×': [2637], 'SDS': [2638], 'Shares': [2648], 'Similarity': [2649], 'Domain': [2652], 'Does': [2654], 'Not': [2655], 'Utilize': [2656], 'IRAK4': [2659, 2804], 'Induction—Although': [2662], 'information': [2664], 'exists': [2665, 3015], 'recent': [2674], 'members': [2679, 3598], 'human': [2681], 'share': [2685], 'some': [2686], 'existing': [2691], 'TLR/IL-1R': [2693, 2787], 'members.': [2695], 'similarity': [2697], 'further': [2699, 2774, 2810, 3085], 'supported': [2700], 'phylogenic': [2703], 'IL-17Rs,': [2712], 'IL-1R': [2715, 2748], '(Fig.': [2716, 2762, 2828, 2972, 3034, 3082, 3139, 3204, 3294, 3323, 3357, 3373, 3420, 3483, 3501], '1A).': [2717], 'tested': [2721, 2890], 'proximal': [2725, 2838], 'units': [2727], 'those': [2729, 2842], 'TIR-containing': [2732], 'receptors.': [2733], 'most': [2741], 'produced': [2752, 3102], 'equally': [2753], 'WT': [2755, 3342, 3361], 'upon': [2759, 3344, 3564], '1B),': [2763], 'indicating': [2764, 3141, 3206, 3347, 3507], 'investigated': [2775, 3258], 'involvement': [2777], 'acts': [2805], 'recruit': [2807], 'IRAK1,': [2808], 'interacts': [2811], 'activation.': [2817, 3385], 'Upon': [2818, 3302], 'treatment,': [2820, 3346], 'preserved': [2824], '1B).': [2829], 'concluded': [2832], 'different': [2837], 'subunits': [2840], 'TIR.': [2845], 'Physically': [2847], 'Associates': [2848], 'Its': [2852], 'Domain—In': [2854], 'addition': [2855], 'interact': [2864, 2878], 'TRAF6,': [2866], 'reasoned': [2874], 'can': [2893, 3144, 3211], 'Full-length': [2897, 2927], 'full-length': [2904, 3095], 'subcloned': [2912], 'vectors': [2915], 'determine': [2919], 'When': [2926], 'HA-tagged': [2928, 2964, 3183], 'FLAG-tagged': [2931], '(16Kramer': [2933], 'J.M.': [2934], 'Yi': [2935], 'Shen': [2937], 'Maitra': [2939], 'Jiao': [2941], 'Jin': [2943], '176:': [2950], '711-715Crossref': [2951], '(85)': [2954], 'Scholar)': [2956], 'simultaneously': [2959], '293': [2962, 3179], 'cells,': [2963], 'co-immunoprecipitated': [2967], 'antibody': [2971], '2A),': [2973], 'indirectly.': [2983], 'co-precipitated': [2987, 3029], 'FLAG-IL-17RA,': [2989], 'previous': [2993], 'complex.': [3019, 3546], 'contrast,': [3021], 'under': [3023], 'condition': [3026], '2A).': [3035], 'To': [3036, 3084, 3147, 3254, 3386], 'examine': [3037, 3148], 'physiological': [3048], 'setting,': [3049], 'lung': [3053], 'epithelial': [3054], 'line,': [3056], 'A549,': [3057], 'immunoprecipitated': [3063], 'anti-IL-17RA': [3066], 'Endogenous': [3068], 'constitutively': [3071], 'transiently': [3077], 'enhanced': [3078], '2B).': [3083], 'assess': [3086], 'direct': [3092], 'association,': [3093], 'recombinant': [3094], 'system.': [3109], 'construct': [3113, 3276, 3644], 'purified': [3122], 'Escherichia': [3124], 'coli.': [3125], 'assay': [3129], 'revealed': [3130], 'indeed': [3134], '2C),': [3140], 'interact.': [3146], 'mediated': [3153, 3215, 3628], 'interaction,': [3157], 'bacterially': [3159], 'containing': [3164], 'precipitate': [3173], 'Indeed,': [3188], 'control': [3195], 'sufficient': [3197], 'pull': [3199], 'down': [3200], '2D),': [3205], 'physically': [3221], 'be': [3227, 3262], 'Is': [3233], 'Required': [3234], 'Gene': [3237], 'Expression—Next': [3238], 'examined': [3240, 3391], 'between': [3244], 'IL-17-mediated': [3251, 3581], 'facilitate': [3255], 'this,': [3256], 'could': [3261], 'silenced': [3263], 'Act1-specific': [3266], 'shRNA.': [3267, 3279], 'established': [3272], 'As': [3280], 'determined': [3281], 'blot,': [3284], 'reduced': [3287, 3316], 'over': [3288], '70%': [3289], '3A),': [3295], 'indicative': [3296], 'efficient': [3298], 'silencing': [3299], 'treatments': [3303], 'about': [3318], '50%': [3319], 'Act1-shRNA': [3321, 3335, 3363], '3B).': [3324], 'addition,': [3326, 3435], 'maintained': [3333], 'while': [3337], 'degraded': [3340, 3367], 'critical': [3349], 'activating': [3354], '3C).': [3358], 'Since': [3359], 'efficiently': [3366], 'response': [3370], '3C),': [3374], 'selectively': [3377, 3510], 'substantiate': [3387], 'observation,': [3389], 'wild-type': [3396], 'Up-regulation': [3404], 'MCP-1(CCL2)': [3409], 'MCP-3(CCL7)': [3411], 'completely': [3413], 'abrogated': [3414], '3D).': [3421], 'induces': [3428], 'factors,': [3430], 'C/EBPβ': [3431], 'C/EBPδ.': [3433], 'inducible': [3438], 'nuclear': [3439], 'highly': [3443], 'homologous': [3444], 'Bcl-3,': [3450], '(17Shen': [3455], 'Ruddy': [3457], 'Plamondon': [3459], 'Leukocyte': [3464], '77:': [3467], '388-399Crossref': [3468], '(224)': [3471], 'Inductions': [3474], 'transcriptional': [3477], 'regulators': [3478], 'depended': [3480], '3E).': [3484], 'Act1-silenced': [3491], '-deficient': [3493], 'IL-1β,': [3498], 'LPS': [3500], '3,': [3502], 'B,': [3503], 'D,': [3504], 'E),': [3506], 'fibroblasts.': [3516], 'Altogether,': [3517], 'our': [3518, 3572], 'demonstrates': [3520], 'use': [3523], 'adaptor,': [3526], 'recruits': [3538], 'intermediates': [3543], 'leads': [3552], 'impaired': [3554], 'deficiency': [3558], 'treatment.': [3566], 'Based': [3567], 'observations,': [3573], 'expect': [3575], 'significant': [3576], 'contribution': [3577], 'disease.': [3583], 'Additional': [3584], 'studies': [3585], 'elucidate': [3589], 'how': [3590], 'organized,': [3595], 'Act1-independent': [3607], 'exists.': [3612], 'Nonetheless,': [3613], 'suggests': [3617], 'interruption': [3619], 'Act1-dependent': [3621], 'events': [3623], 'help': [3625, 3699], 'alleviate': [3626], 'immunopathology': [3627], 'IL-17-producing': [3632], 'cells.': [3634], 'thank': [3636], 'FLAG-MyD88': [3643], 'MyD88-deficient': [3646], 'MEFs,': [3647], 'Toronto)': [3653], 'NY)': [3666], 'FLAG-IL-17RA': [3668], 'Drs.': [3670], 'Xiaoxia': [3671], 'Caini': [3674], '(Cleveland': [3676], 'Clinic': [3677], 'Learner': [3678], 'Research': [3679], 'Institute)': [3680], 'providing': [3682], 'samples': [3684], 'cytokine-treated': [3686], 'Act-1-deficient': [3687], 'discussion,': [3692], 'entire': [3695], 'Laboratory': [3697], 'discussion.': [3701]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2081025997', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 26}, {'year': 2012, 'cited_by_count': 23}], 'updated_date': '2025-01-04T00:48:28.997954', 'created_date': '2016-06-24'}
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