Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2080981165', 'doi': 'https://doi.org/10.1038/onc.2008.86', 'title': 'Activated c-Abl tyrosine kinase in malignant solid tumors', 'display_name': 'Activated c-Abl tyrosine kinase in malignant solid tumors', 'publication_year': 2008, 'publication_date': '2008-04-07', 'ids': {'openalex': 'https://openalex.org/W2080981165', 'doi': 'https://doi.org/10.1038/onc.2008.86', 'mag': '2080981165', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18391983'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2008.86', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1038/onc.2008.86', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080144734', 'display_name': 'Jinxiong Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I919571938', 'display_name': 'The University of Texas Health Science Center at Houston', 'ror': 'https://ror.org/03gds6c39', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I919571938']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J Lin', 'raw_affiliation_strings': ['Department of Molecular Pathology, MD Anderson Cancer Center, University of Texas, Houston, TX 77054, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, MD Anderson Cancer Center, University of Texas, Houston, TX 77054, USA.', 'institution_ids': ['https://openalex.org/I919571938']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065538168', 'display_name': 'Ralph B. Arlinghaus', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R Arlinghaus', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4390, 'currency': 'EUR', 'value_usd': 5490, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.266, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 62, 'citation_normalized_percentile': {'value': 0.760286, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '27', 'issue': '32', 'first_page': '4385', 'last_page': '4391'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11215', 'display_name': 'Efficacy and Resistance in CML Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11215', 'display_name': 'Efficacy and Resistance in CML Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10755', 'display_name': 'HER2 Signaling in Breast Cancer Treatment', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/abl', 'display_name': 'ABL', 'score': 0.74454135}, {'id': 'https://openalex.org/keywords/cd135', 'display_name': 'CD135', 'score': 0.5681987}, {'id': 'https://openalex.org/keywords/protein-kinase-domain', 'display_name': 'Protein kinase domain', 'score': 0.5496212}, {'id': 'https://openalex.org/keywords/receptor-tyrosine-kinase', 'display_name': 'Receptor Tyrosine Kinase', 'score': 0.482329}, {'id': 'https://openalex.org/keywords/ror1', 'display_name': 'ROR1', 'score': 0.4228025}], 'concepts': [{'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.75771874}, {'id': 'https://openalex.org/C125418893', 'wikidata': 'https://www.wikidata.org/wiki/Q587961', 'display_name': 'ABL', 'level': 4, 'score': 0.74454135}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.74259824}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.67538565}, {'id': 'https://openalex.org/C41650920', 'wikidata': 'https://www.wikidata.org/wiki/Q14912399', 'display_name': 'CD135', 'level': 4, 'score': 0.5681987}, {'id': 'https://openalex.org/C123894998', 'wikidata': 'https://www.wikidata.org/wiki/Q425158', 'display_name': 'Fusion protein', 'level': 4, 'score': 0.56430715}, {'id': 'https://openalex.org/C32619005', 'wikidata': 'https://www.wikidata.org/wiki/Q24768234', 'display_name': 'Protein kinase domain', 'level': 4, 'score': 0.5496212}, {'id': 'https://openalex.org/C108636557', 'wikidata': 'https://www.wikidata.org/wiki/Q21109354', 'display_name': 'Proto-oncogene tyrosine-protein kinase Src', 'level': 3, 'score': 0.53162235}, {'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.52185595}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.5174254}, {'id': 'https://openalex.org/C111829193', 'wikidata': 'https://www.wikidata.org/wiki/Q1108970', 'display_name': 'Fusion gene', 'level': 3, 'score': 0.47417843}, {'id': 'https://openalex.org/C23440912', 'wikidata': 'https://www.wikidata.org/wiki/Q18030230', 'display_name': 'ROR1', 'level': 5, 'score': 0.4228025}, {'id': 'https://openalex.org/C180361614', 'wikidata': 'https://www.wikidata.org/wiki/Q7202242', 'display_name': 'Platelet-derived growth factor receptor', 'level': 4, 'score': 0.32485843}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.26777565}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.23383042}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1812121}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.17159992}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11690351}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.08774197}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.07732949}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D016315', 'descriptor_name': 'Proto-Oncogene Proteins c-abl', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016315', 'descriptor_name': 'Proto-Oncogene Proteins c-abl', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016315', 'descriptor_name': 'Proto-Oncogene Proteins c-abl', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011519', 'descriptor_name': 'Proto-Oncogenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2008.86', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18391983', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2008.86', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.81, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1490283529', 'https://openalex.org/W1490860457', 'https://openalex.org/W1606221044', 'https://openalex.org/W1968572823', 'https://openalex.org/W1970285990', 'https://openalex.org/W1973568055', 'https://openalex.org/W1979419538', 'https://openalex.org/W1981976777', 'https://openalex.org/W1993314049', 'https://openalex.org/W2005978545', 'https://openalex.org/W2006467763', 'https://openalex.org/W2006694659', 'https://openalex.org/W2011858503', 'https://openalex.org/W2020748852', 'https://openalex.org/W2023569481', 'https://openalex.org/W2025453886', 'https://openalex.org/W2028666409', 'https://openalex.org/W2028996996', 'https://openalex.org/W2029229855', 'https://openalex.org/W2031548070', 'https://openalex.org/W2031752845', 'https://openalex.org/W2051381056', 'https://openalex.org/W2056795440', 'https://openalex.org/W2068582092', 'https://openalex.org/W2084024014', 'https://openalex.org/W2093941322', 'https://openalex.org/W2094418791', 'https://openalex.org/W2099981464', 'https://openalex.org/W2105241306', 'https://openalex.org/W2106602239', 'https://openalex.org/W2112688349', 'https://openalex.org/W2134615815', 'https://openalex.org/W2158861987', 'https://openalex.org/W2161428561', 'https://openalex.org/W2171991850', 'https://openalex.org/W4236285365', 'https://openalex.org/W4285719527', 'https://openalex.org/W4321317624'], 'related_works': ['https://openalex.org/W2403309655', 'https://openalex.org/W2384146820', 'https://openalex.org/W2326027500', 'https://openalex.org/W2325509791', 'https://openalex.org/W2259593659', 'https://openalex.org/W2146321751', 'https://openalex.org/W2132334410', 'https://openalex.org/W2069153761', 'https://openalex.org/W2023447434', 'https://openalex.org/W1975812434'], 'abstract_inverted_index': {'Mutant': [0], 'forms': [1], 'of': [2, 44, 49, 81], 'the': [3, 30, 63], 'c-ABL': [4], 'gene': [5, 27], 'are': [6], 'well': [7], 'known': [8], 'to': [9, 47], 'be': [10], 'involved': [11], 'in': [12, 77], 'hematopoietic': [13], 'malignancies': [14], 'such': [15], 'as': [16, 69], 'chronic': [17], 'myeloid': [18], 'leukemia': [19], '(CML).': [20], 'CML': [21], 'patients': [22], 'possess': [23], 'a': [24, 70], 'fused': [25], 'BCR-ABL': [26], 'that': [28, 41, 62], 'activates': [29], 'Abl': [31, 45], 'tyrosine': [32, 51, 66], 'kinase': [33, 52], 'domain': [34], 'within': [35], 'Bcr-Abl.': [36], 'In': [37, 54], 'general': [38], 'fusion': [39, 71], 'proteins': [40], 'cause': [42], 'oligomerization': [43], 'lead': [46], 'activation': [48], 'its': [50], 'activity.': [53], 'this': [55], 'review,': [56], 'we': [57], 'highlight': [58], 'recent': [59], 'discoveries': [60], 'indicating': [61], 'activated': [64], 'c-Abl': [65], 'kinase,': [67], 'not': [68], 'protein,': [72], 'plays': [73], 'an': [74], 'important': [75], 'role': [76], 'malignant': [78], 'solid': [79], 'tumors': [80], 'lung': [82], 'and': [83], 'breast.': [84]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2080981165', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-08-13T14:37:28.824974', 'created_date': '2016-06-24'}