Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2080915831', 'doi': 'https://doi.org/10.1016/s0968-0896(03)00123-8', 'title': '2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine A2A receptor', 'display_name': '2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine A2A receptor', 'publication_year': 2003, 'publication_date': '2003-04-24', 'ids': {'openalex': 'https://openalex.org/W2080915831', 'doi': 'https://doi.org/10.1016/s0968-0896(03)00123-8', 'mag': '2080915831', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12713828'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0968-0896(03)00123-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10422866', 'display_name': 'Bioorganic & Medicinal Chemistry', 'issn_l': '0968-0896', 'issn': ['0968-0896', '1464-3391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041188417', 'display_name': 'Erica W. van Tilburg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210133171', 'display_name': 'Centre for Human Drug Research', 'ror': 'https://ror.org/044hshx49', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133171']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Erica W van Tilburg', 'raw_affiliation_strings': ['Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I4210133171']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070266614', 'display_name': 'Matty Gremmen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210133171', 'display_name': 'Centre for Human Drug Research', 'ror': 'https://ror.org/044hshx49', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133171']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Matty Gremmen', 'raw_affiliation_strings': ['Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I4210133171']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060016184', 'display_name': 'Jacobien von Frijtag Drabbe Künzel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210133171', 'display_name': 'Centre for Human Drug Research', 'ror': 'https://ror.org/044hshx49', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133171']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jacobien von Frijtag Drabbe Künzel', 'raw_affiliation_strings': ['Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I4210133171']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080119245', 'display_name': 'Miriam de Groote', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210133171', 'display_name': 'Centre for Human Drug Research', 'ror': 'https://ror.org/044hshx49', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133171']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Miriam de Groote', 'raw_affiliation_strings': ['Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I4210133171']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065525958', 'display_name': 'Adriaan P. IJzerman', 'orcid': 'https://orcid.org/0000-0002-1182-2259'}, 'institutions': [{'id': 'https://openalex.org/I4210133171', 'display_name': 'Centre for Human Drug Research', 'ror': 'https://ror.org/044hshx49', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133171']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ad P IJzerman', 'raw_affiliation_strings': ['Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I4210133171']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3690, 'currency': 'USD', 'value_usd': 3690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.955, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.809588, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '11', 'issue': '10', 'first_page': '2183', 'last_page': '2192'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cgs-21680', 'display_name': 'CGS-21680', 'score': 0.9242101}, {'id': 'https://openalex.org/keywords/adenosine-a2a-receptor', 'display_name': 'Adenosine A2A receptor', 'score': 0.6673162}, {'id': 'https://openalex.org/keywords/adenosine-a1-receptor', 'display_name': 'Adenosine A1 receptor', 'score': 0.5589588}], 'concepts': [{'id': 'https://openalex.org/C2780231331', 'wikidata': 'https://www.wikidata.org/wiki/Q5010992', 'display_name': 'CGS-21680', 'level': 5, 'score': 0.9242101}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.8815243}, {'id': 'https://openalex.org/C2776991684', 'wikidata': 'https://www.wikidata.org/wiki/Q190012', 'display_name': 'Adenosine', 'level': 2, 'score': 0.85585725}, {'id': 'https://openalex.org/C67907053', 'wikidata': 'https://www.wikidata.org/wiki/Q356147', 'display_name': 'Adenosine receptor', 'level': 4, 'score': 0.78638995}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.7700079}, {'id': 'https://openalex.org/C58732023', 'wikidata': 'https://www.wikidata.org/wiki/Q770260', 'display_name': 'Partial agonist', 'level': 4, 'score': 0.70722306}, {'id': 'https://openalex.org/C2778491162', 'wikidata': 'https://www.wikidata.org/wiki/Q3063865', 'display_name': 'Adenosine A2A receptor', 'level': 5, 'score': 0.6673162}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6237809}, {'id': 'https://openalex.org/C182683403', 'wikidata': 'https://www.wikidata.org/wiki/Q14888579', 'display_name': 'Adenosine A1 receptor', 'level': 5, 'score': 0.5589588}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.45376223}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2903446}], 'mesh': [{'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D058908', 'descriptor_name': 'Adenosine A2 Receptor Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058907', 'descriptor_name': 'Adenosine A1 Receptor Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008744', 'descriptor_name': 'Methylamines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008744', 'descriptor_name': 'Methylamines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008744', 'descriptor_name': 'Methylamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008956', 'descriptor_name': 'Models, Chemical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011437', 'descriptor_name': 'Propylamines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011437', 'descriptor_name': 'Propylamines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011437', 'descriptor_name': 'Propylamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011869', 'descriptor_name': 'Radioligand Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0968-0896(03)00123-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10422866', 'display_name': 'Bioorganic & Medicinal Chemistry', 'issn_l': '0968-0896', 'issn': ['0968-0896', '1464-3391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12713828', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1964296067', 'https://openalex.org/W1970779552', 'https://openalex.org/W1983693956', 'https://openalex.org/W1988283362', 'https://openalex.org/W1990048241', 'https://openalex.org/W1998338870', 'https://openalex.org/W2000064569', 'https://openalex.org/W2000216297', 'https://openalex.org/W2000487734', 'https://openalex.org/W2005174158', 'https://openalex.org/W2012112927', 'https://openalex.org/W2037664518', 'https://openalex.org/W2040831332', 'https://openalex.org/W2047530934', 'https://openalex.org/W2051638077', 'https://openalex.org/W2054911660', 'https://openalex.org/W2056596373', 'https://openalex.org/W2062214351', 'https://openalex.org/W2063822859', 'https://openalex.org/W2065730544', 'https://openalex.org/W2068139152', 'https://openalex.org/W2070628499', 'https://openalex.org/W2073561633', 'https://openalex.org/W2075101183', 'https://openalex.org/W2077408452', 'https://openalex.org/W2077765096', 'https://openalex.org/W2078723380', 'https://openalex.org/W2085337786', 'https://openalex.org/W2085672169', 'https://openalex.org/W2092071960', 'https://openalex.org/W2099757747', 'https://openalex.org/W2129450338', 'https://openalex.org/W2132088139', 'https://openalex.org/W2167106293', 'https://openalex.org/W2252856753', 'https://openalex.org/W2257798476', 'https://openalex.org/W2409916978'], 'related_works': ['https://openalex.org/W2338280163', 'https://openalex.org/W2163784706', 'https://openalex.org/W2122977772', 'https://openalex.org/W2090162485', 'https://openalex.org/W2087962024', 'https://openalex.org/W2080915831', 'https://openalex.org/W2031254193', 'https://openalex.org/W2013457041', 'https://openalex.org/W2006505301', 'https://openalex.org/W1893746691'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2080915831', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-16T17:18:04.095524', 'created_date': '2016-06-24'}