Publication Information

{'id': 'https://openalex.org/W2080845240', 'doi': 'https://doi.org/10.1080/15216549600201582', 'title': 'Bisindolylmaleimide inhibits the PMA-induced down-regulation of collagen synthesis in fibroblasts', 'display_name': 'Bisindolylmaleimide inhibits the PMA-induced down-regulation of collagen synthesis in fibroblasts', 'publication_year': 1996, 'publication_date': '1996-09-01', 'ids': {'openalex': 'https://openalex.org/W2080845240', 'doi': 'https://doi.org/10.1080/15216549600201582', 'mag': '2080845240', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8886275'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/15216549600201582', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1080/15216549600201582', 'source': {'id': 'https://openalex.org/S203723150', 'display_name': 'IUBMB Life', 'issn_l': '1521-6543', 'issn': ['1521-6543', '1521-6551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1080/15216549600201582', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063611306', 'display_name': 'Rang‐Woon Park', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31419693', 'display_name': 'Kyungpook National University', 'ror': 'https://ror.org/040c17130', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I31419693']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Rang‐Woon Park', 'raw_affiliation_strings': ['Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Taegu, 700-422, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Taegu, 700-422, Korea', 'institution_ids': ['https://openalex.org/I31419693']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009476522', 'display_name': 'In‐San Kim', 'orcid': 'https://orcid.org/0000-0003-1714-4521'}, 'institutions': [{'id': 'https://openalex.org/I31419693', 'display_name': 'Kyungpook National University', 'ror': 'https://ror.org/040c17130', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I31419693']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'In‐San Kim', 'raw_affiliation_strings': ['Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Taegu, 700-422, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Taegu, 700-422, Korea', 'institution_ids': ['https://openalex.org/I31419693']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070046073', 'display_name': 'Joon‐Seung Jo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31419693', 'display_name': 'Kyungpook National University', 'ror': 'https://ror.org/040c17130', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I31419693']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Joon‐Seung Jo', 'raw_affiliation_strings': ['Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Taegu, 700-422, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Taegu, 700-422, Korea', 'institution_ids': ['https://openalex.org/I31419693']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.129, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.44269, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 74, 'max': 76}, 'biblio': {'volume': '40', 'issue': '1', 'first_page': '101', 'last_page': '109'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9871, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9871, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9773, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9759, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bisindolylmaleimide', 'display_name': 'Bisindolylmaleimide', 'score': 0.8745411}, {'id': 'https://openalex.org/keywords/phorbol', 'display_name': 'Phorbol', 'score': 0.69412327}], 'concepts': [{'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.9413848}, {'id': 'https://openalex.org/C2777314051', 'wikidata': 'https://www.wikidata.org/wiki/Q27075304', 'display_name': 'Bisindolylmaleimide', 'level': 4, 'score': 0.8745411}, {'id': 'https://openalex.org/C2780043322', 'wikidata': 'https://www.wikidata.org/wiki/Q2705359', 'display_name': 'Phorbol', 'level': 4, 'score': 0.69412327}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50315803}, {'id': 'https://openalex.org/C2780381497', 'wikidata': 'https://www.wikidata.org/wiki/Q463418', 'display_name': 'Fibroblast', 'level': 3, 'score': 0.44599888}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.39929572}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.39549416}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32927775}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32630917}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23233414}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.19741619}], 'mesh': [{'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008301', 'descriptor_name': 'Maleimides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003513', 'descriptor_name': 'Cycloheximide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003513', 'descriptor_name': 'Cycloheximide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004075', 'descriptor_name': 'Diglycerides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004075', 'descriptor_name': 'Diglycerides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005987', 'descriptor_name': 'Glyceraldehyde-3-Phosphate Dehydrogenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005987', 'descriptor_name': 'Glyceraldehyde-3-Phosphate Dehydrogenases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008301', 'descriptor_name': 'Maleimides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011347', 'descriptor_name': 'Procollagen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011347', 'descriptor_name': 'Procollagen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/15216549600201582', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1080/15216549600201582', 'source': {'id': 'https://openalex.org/S203723150', 'display_name': 'IUBMB Life', 'issn_l': '1521-6543', 'issn': ['1521-6543', '1521-6551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8886275', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/15216549600201582', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1080/15216549600201582', 'source': {'id': 'https://openalex.org/S203723150', 'display_name': 'IUBMB Life', 'issn_l': '1521-6543', 'issn': ['1521-6543', '1521-6551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.42, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2084059091', 'https://openalex.org/W2080845240', 'https://openalex.org/W2071823273', 'https://openalex.org/W2014302889', 'https://openalex.org/W1991320440', 'https://openalex.org/W1987534701', 'https://openalex.org/W1972648199', 'https://openalex.org/W1963645455', 'https://openalex.org/W1871049564', 'https://openalex.org/W1523620726'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1], 'assessed': [2], 'the': [3, 11, 28, 52, 114], 'role': [4], 'of': [5, 13, 31, 72, 78], 'protein': [6], 'kinase': [7], 'C': [8], '(PKC)': [9], 'in': [10, 34, 40, 81], 'regulation': [12], 'collagen': [14, 32, 53, 66, 79, 102, 109], 'synthesis.': [15, 54, 67, 103], 'Two': [16], 'PKC': [17, 88, 118], 'activators,': [18], 'Phorbol': [19], '12‐myristate': [20], '13‐acetate': [21], '(PMA)': [22], 'and': [23, 37, 60, 94], '1‐oleyl': [24], '2‐acetyl‐sn‐glycerol': [25], '(OAG),': [26], 'decreased': [27], 'relative': [29], 'rate': [30], 'synthesis': [33, 80, 110], 'a': [35, 69, 82], 'dose‐': [36], 'time‐dependent': [38], 'manner': [39], 'fibroblasts,': [41], 'whereas': [42], 'an': [43], 'inactive': [44], 'phorbol': [45], 'ester,': [46], '4α‐phorbol': [47], 'didecanoate': [48], 'failed': [49, 96], 'to': [50, 64, 97], 'affect': [51], 'In': [55], 'PKC‐depleted': [56], 'cells': [57], 'both': [58], 'PMA': [59, 99], 'OAG': [61], 'were': [62], 'unable': [63], 'inhibit': [65], 'Bisindolylmaleimide,': [68], 'specific': [70], 'inhibitor': [71], 'PKC,': [73], 'completely': [74], 'abrogated': [75], 'PMA‐induced': [76], 'inhibition': [77], 'dose‐dependent': [83], 'fashion': [84], 'while': [85], 'two': [86], 'other': [87], 'inhibitors': [89], 'with': [90], 'low': [91], 'specificity,': [92], 'H7': [93], 'staurosporin': [95], 'block': [98], 'effect': [100], 'on': [101], 'The': [104], 'results': [105], 'provide': [106], 'evidence': [107], 'that': [108], 'is': [111], 'regulated': [112], 'through': [113], 'signal': [115], 'pathway': [116], 'involving': [117], 'activation.': [119]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2080845240', 'counts_by_year': [], 'updated_date': '2024-12-09T00:41:15.765955', 'created_date': '2016-06-24'}