Publication Information

{'id': 'https://openalex.org/W2080809034', 'doi': 'https://doi.org/10.1371/journal.pone.0055922', 'title': 'Apigenin Sensitizes Prostate Cancer Cells to Apo2L/TRAIL by Targeting Adenine Nucleotide Translocase-2', 'display_name': 'Apigenin Sensitizes Prostate Cancer Cells to Apo2L/TRAIL by Targeting Adenine Nucleotide Translocase-2', 'publication_year': 2013, 'publication_date': '2013-02-19', 'ids': {'openalex': 'https://openalex.org/W2080809034', 'doi': 'https://doi.org/10.1371/journal.pone.0055922', 'mag': '2080809034', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23431365', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3576345'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0055922', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055922&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055922&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100994451', 'display_name': 'Masakatsu Oishi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Masakatsu Oishi', 'raw_affiliation_strings': ['Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan', 'Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I40677808']}, {'raw_affiliation_string': 'Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I40677808']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031716492', 'display_name': 'Yosuke Iizumi', 'orcid': 'https://orcid.org/0000-0001-6432-2090'}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yosuke Iizumi', 'raw_affiliation_strings': ['Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I40677808']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105525422', 'display_name': 'Tomoyuki Taniguchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Tomoyuki Taniguchi', 'raw_affiliation_strings': ['Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I40677808']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051288987', 'display_name': 'Wakana Goi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Wakana Goi', 'raw_affiliation_strings': ['Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I40677808']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113821547', 'display_name': 'Tsuneharu Miki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Tsuneharu Miki', 'raw_affiliation_strings': ['Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I40677808']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013263645', 'display_name': 'Toshiyuki Sakai', 'orcid': 'https://orcid.org/0000-0002-7865-2258'}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Toshiyuki Sakai', 'raw_affiliation_strings': ['Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I40677808']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5100994451', 'https://openalex.org/A5031716492', 'https://openalex.org/A5105525422', 'https://openalex.org/A5051288987', 'https://openalex.org/A5113821547', 'https://openalex.org/A5013263645'], 'corresponding_institution_ids': ['https://openalex.org/I40677808', 'https://openalex.org/I40677808', 'https://openalex.org/I40677808', 'https://openalex.org/I40677808', 'https://openalex.org/I40677808', 'https://openalex.org/I40677808'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 1.934, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 62, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '8', 'issue': '2', 'first_page': 'e55922', 'last_page': 'e55922'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778609962', 'wikidata': 'https://www.wikidata.org/wiki/Q424567', 'display_name': 'Apigenin', 'level': 4, 'score': 0.9634397}, {'id': 'https://openalex.org/C2778298627', 'wikidata': 'https://www.wikidata.org/wiki/Q415957', 'display_name': 'Genistein', 'level': 2, 'score': 0.6632569}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6573683}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.59164375}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.58369863}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.50450504}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.43262815}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33251232}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32240534}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30889624}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2310341}, {'id': 'https://openalex.org/C2779054382', 'wikidata': 'https://www.wikidata.org/wiki/Q72185287', 'display_name': 'Flavonoid', 'level': 3, 'score': 0.2060684}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1374071}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.106630325}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D033742', 'descriptor_name': 'Adenine Nucleotide Translocator 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D047310', 'descriptor_name': 'Apigenin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D053221', 'descriptor_name': 'TNF-Related Apoptosis-Inducing Ligand', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D033742', 'descriptor_name': 'Adenine Nucleotide Translocator 2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D033742', 'descriptor_name': 'Adenine Nucleotide Translocator 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D033742', 'descriptor_name': 'Adenine Nucleotide Translocator 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047310', 'descriptor_name': 'Apigenin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D047310', 'descriptor_name': 'Apigenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019833', 'descriptor_name': 'Genistein', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D019833', 'descriptor_name': 'Genistein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053220', 'descriptor_name': 'Receptors, TNF-Related Apoptosis-Inducing Ligand', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053220', 'descriptor_name': 'Receptors, TNF-Related Apoptosis-Inducing Ligand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053220', 'descriptor_name': 'Receptors, TNF-Related Apoptosis-Inducing Ligand', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053221', 'descriptor_name': 'TNF-Related Apoptosis-Inducing Ligand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0055922', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055922&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/c8968cb76c134178b18d36c1d69487bf', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3576345', 'pdf_url': 'https://europepmc.org/articles/pmc3576345?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576345', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23431365', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0055922', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055922&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.87}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1484817497', 'https://openalex.org/W1576344981', 'https://openalex.org/W1854708637', 'https://openalex.org/W1970516269', 'https://openalex.org/W1972831640', 'https://openalex.org/W1975617209', 'https://openalex.org/W1987506447', 'https://openalex.org/W1992660664', 'https://openalex.org/W1997952190', 'https://openalex.org/W2000148777', 'https://openalex.org/W2025582487', 'https://openalex.org/W2029712420', 'https://openalex.org/W2053484488', 'https://openalex.org/W2054054828', 'https://openalex.org/W2059949336', 'https://openalex.org/W2062473455', 'https://openalex.org/W2083403240', 'https://openalex.org/W2091776758', 'https://openalex.org/W2094570524', 'https://openalex.org/W2096538680', 'https://openalex.org/W2098786321', 'https://openalex.org/W2106787323', 'https://openalex.org/W2107069275', 'https://openalex.org/W2107371485', 'https://openalex.org/W2111849727', 'https://openalex.org/W2116252316', 'https://openalex.org/W2118880189', 'https://openalex.org/W2119098656', 'https://openalex.org/W2120292596', 'https://openalex.org/W2132527654', 'https://openalex.org/W2171944258', 'https://openalex.org/W2417184409'], 'related_works': ['https://openalex.org/W3151035265', 'https://openalex.org/W3013649233', 'https://openalex.org/W2564604320', 'https://openalex.org/W2392497817', 'https://openalex.org/W2313377632', 'https://openalex.org/W205309064', 'https://openalex.org/W2047579452', 'https://openalex.org/W2034366718', 'https://openalex.org/W2002628816', 'https://openalex.org/W182107157'], 'abstract_inverted_index': {'Apo2': [0], 'ligand': [1, 6], '(Apo2L)/tumor': [2], 'necrosis': [3], 'factor-related': [4], 'apoptosis-inducing': [5], '(TRAIL)': [7], 'is': [8], 'a': [9, 140], 'promising': [10], 'cancer': [11, 105], 'therapeutic': [12], 'agent.': [13], 'Recombinant': [14], 'human': [15], 'Apo2L/TRAIL': [16, 46, 200], 'has': [17], 'been': [18], 'under': [19], 'clinical': [20], 'trials,': [21], 'whereas': [22], 'various': [23], 'kinds': [24], 'of': [25, 87, 92, 122, 129, 133, 142, 151, 166, 171], 'malignant': [26, 54], 'tumors': [27], 'have': [28, 35], 'resistance': [29, 44], 'to': [30, 45, 148, 199], 'Apo2L/TRAIL.': [31], 'We': [32, 135, 192], 'and': [33, 41, 78, 95, 183, 189], 'others': [34], 'shown': [36], 'that': [37, 72, 137, 179, 194], 'several': [38], 'anticancer': [39], 'agents': [40], 'flavonoids': [42], 'overcome': [43], 'by': [47, 60, 90, 156, 174, 187], 'upregulating': [48, 157], 'death': [49], 'receptor': [50], '5': [51], '(DR5)': [52], 'in': [53, 85, 104], 'tumor': [55], 'cells.': [56, 106], 'However,': [57], 'the': [58, 73, 119, 126, 161, 169], 'mechanisms': [59], 'which': [61, 97], 'these': [62], 'compounds': [63], 'induce': [64], 'DR5': [65, 109, 158, 182], 'expression': [66, 159], 'remain': [67], 'unknown.': [68], 'Here': [69], 'we': [70, 124], 'show': [71], 'dietary': [74], 'flavonoid': [75], 'apigenin': [76, 130, 180], 'binds': [77], 'inhibits': [79], 'adenine': [80], 'nucleotide': [81], 'translocase-2': [82], '(ANT2),': [83], 'resulting': [84], 'enhancement': [86, 170], 'Apo2L/TRAIL-induced': [88, 102, 154, 172, 185], 'apoptosis': [89, 103, 155, 173, 186], 'upregulation': [91], 'DR5.': [93], 'Apigenin': [94, 107], 'genistein,': [96], 'are': [98], 'major': [99], 'flavonoids,': [100, 123], 'enhanced': [101, 153], 'induced': [108], 'expression,': [110], 'but': [111, 144], 'genistein': [112], 'did': [113], 'not.': [114], 'Using': [115], 'our': [116], 'method': [117], 'identifying': [118], 'direct': [120], 'targets': [121], 'compared': [125], 'binding': [127, 188], 'proteins': [128], 'with': [131], 'those': [132], 'genistein.': [134, 146], 'discovered': [136], 'ANT2': [138, 152, 167, 195], 'was': [139], 'target': [141], 'apigenin,': [143, 149], 'not': [145], 'Similarly': [147], 'knockdown': [150], 'at': [160], 'post-transcriptional': [162], 'level.': [163], 'Moreover,': [164], 'silencing': [165], 'attenuated': [168], 'apigenin.': [175], 'These': [176], 'results': [177], 'suggest': [178], 'upregulates': [181], 'enhances': [184], 'inhibiting': [190], 'ANT2.': [191], 'propose': [193], 'inhibitors': [196], 'may': [197], 'contribute': [198], 'therapy.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2080809034', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-13T17:54:27.151926', 'created_date': '2016-06-24'}