Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2080352183', 'doi': 'https://doi.org/10.3390/toxins7010034', 'title': 'Plectasin, First Animal Toxin-Like Fungal Defensin Blocking Potassium Channels through Recognizing Channel Pore Region', 'display_name': 'Plectasin, First Animal Toxin-Like Fungal Defensin Blocking Potassium Channels through Recognizing Channel Pore Region', 'publication_year': 2015, 'publication_date': '2015-01-05', 'ids': {'openalex': 'https://openalex.org/W2080352183', 'doi': 'https://doi.org/10.3390/toxins7010034', 'mag': '2080352183', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25568977', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4303811'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/toxins7010034', 'pdf_url': 'https://www.mdpi.com/2072-6651/7/1/34/pdf?version=1420449280', 'source': {'id': 'https://openalex.org/S128990672', 'display_name': 'Toxins', 'issn_l': '2072-6651', 'issn': ['2072-6651'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2072-6651/7/1/34/pdf?version=1420449280', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038926066', 'display_name': 'Xiang Fang', 'orcid': 'https://orcid.org/0000-0003-4415-8515'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fang Xiang', 'raw_affiliation_strings': ['State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026615281', 'display_name': 'Zili Xie', 'orcid': 'https://orcid.org/0000-0002-9060-6780'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zili Xie', 'raw_affiliation_strings': ['State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102940907', 'display_name': 'Jing Feng', 'orcid': 'https://orcid.org/0000-0002-7425-2994'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Feng', 'raw_affiliation_strings': ['State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068637713', 'display_name': 'Weishan Yang', 'orcid': 'https://orcid.org/0000-0001-7735-3128'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weishan Yang', 'raw_affiliation_strings': ['State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088157147', 'display_name': 'Zhijian Cao', 'orcid': 'https://orcid.org/0000-0002-2603-5434'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhijian Cao', 'raw_affiliation_strings': ['Center for BioDrug Research, Wuhan University, Wuhan 430072, China', 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Center for BioDrug Research, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100397215', 'display_name': 'Wenxin Li', 'orcid': 'https://orcid.org/0000-0003-2650-2052'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenxin Li', 'raw_affiliation_strings': ['Center for BioDrug Research, Wuhan University, Wuhan 430072, China', 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China'], 'affiliations': [{'raw_affiliation_string': 'Center for BioDrug Research, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}, {'raw_affiliation_string': 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079263580', 'display_name': 'Zongyun Chen', 'orcid': 'https://orcid.org/0000-0002-9939-186X'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zongyun Chen', 'raw_affiliation_strings': ['State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100638139', 'display_name': 'Yingliang Wu', 'orcid': 'https://orcid.org/0000-0002-7748-9399'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yingliang Wu', 'raw_affiliation_strings': ['Center for BioDrug Research, Wuhan University, Wuhan 430072, China', 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China'], 'affiliations': [{'raw_affiliation_string': 'Center for BioDrug Research, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}, {'raw_affiliation_string': 'State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China', 'institution_ids': ['https://openalex.org/I37461747']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5100638139'], 'corresponding_institution_ids': ['https://openalex.org/I37461747'], 'apc_list': {'value': 2400, 'currency': 'CHF', 'value_usd': 2598, 'provenance': 'doaj'}, 'apc_paid': {'value': 2400, 'currency': 'CHF', 'value_usd': 2598, 'provenance': 'doaj'}, 'fwci': 1.704, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.865308, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '7', 'issue': '1', 'first_page': '34', 'last_page': '42'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11818', 'display_name': 'Structure and Function of Nicotinic Receptors', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides in Host Defense and Therapy', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/potassium-channel-blocker', 'display_name': 'Potassium channel blocker', 'score': 0.7554313}, {'id': 'https://openalex.org/keywords/herg', 'display_name': 'hERG', 'score': 0.6596215}, {'id': 'https://openalex.org/keywords/potassium-channels', 'display_name': 'Potassium Channels', 'score': 0.584975}, {'id': 'https://openalex.org/keywords/sk-channel', 'display_name': 'SK channel', 'score': 0.505846}, {'id': 'https://openalex.org/keywords/channel-blocker', 'display_name': 'Channel blocker', 'score': 0.44237936}], 'concepts': [{'id': 'https://openalex.org/C83743174', 'wikidata': 'https://www.wikidata.org/wiki/Q423778', 'display_name': 'Potassium channel', 'level': 2, 'score': 0.8490791}, {'id': 'https://openalex.org/C2778457506', 'wikidata': 'https://www.wikidata.org/wiki/Q7234689', 'display_name': 'Potassium channel blocker', 'level': 3, 'score': 0.7554313}, {'id': 'https://openalex.org/C2776498113', 'wikidata': 'https://www.wikidata.org/wiki/Q412820', 'display_name': 'Defensin', 'level': 3, 'score': 0.6634194}, {'id': 'https://openalex.org/C2779362680', 'wikidata': 'https://www.wikidata.org/wiki/Q905000', 'display_name': 'hERG', 'level': 3, 'score': 0.6596215}, {'id': 'https://openalex.org/C2780419564', 'wikidata': 'https://www.wikidata.org/wiki/Q5087002', 'display_name': 'Charybdotoxin', 'level': 3, 'score': 0.56478214}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.5605219}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5292228}, {'id': 'https://openalex.org/C2777367657', 'wikidata': 'https://www.wikidata.org/wiki/Q184651', 'display_name': 'Toxin', 'level': 2, 'score': 0.51626706}, {'id': 'https://openalex.org/C149786707', 'wikidata': 'https://www.wikidata.org/wiki/Q7390712', 'display_name': 'SK channel', 'level': 4, 'score': 0.505846}, {'id': 'https://openalex.org/C517785266', 'wikidata': 'https://www.wikidata.org/wiki/Q703', 'display_name': 'Potassium', 'level': 2, 'score': 0.46848524}, {'id': 'https://openalex.org/C153461711', 'wikidata': 'https://www.wikidata.org/wiki/Q5072487', 'display_name': 'Channel blocker', 'level': 3, 'score': 0.44237936}, {'id': 'https://openalex.org/C16318435', 'wikidata': 'https://www.wikidata.org/wiki/Q149299', 'display_name': 'Mutagenesis', 'level': 4, 'score': 0.42522734}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35289598}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34365273}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32810926}, {'id': 'https://openalex.org/C50254741', 'wikidata': 'https://www.wikidata.org/wiki/Q62536', 'display_name': 'Ion channel', 'level': 3, 'score': 0.32516533}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.2559979}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.14425889}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.13216883}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.083954304}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.055184305}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D023082', 'descriptor_name': 'Defensins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009183', 'descriptor_name': 'Mycotoxins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D026902', 'descriptor_name': 'Potassium Channel Blockers', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015221', 'descriptor_name': 'Potassium Channels', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D023082', 'descriptor_name': 'Defensins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009183', 'descriptor_name': 'Mycotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026902', 'descriptor_name': 'Potassium Channel Blockers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015221', 'descriptor_name': 'Potassium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/toxins7010034', 'pdf_url': 'https://www.mdpi.com/2072-6651/7/1/34/pdf?version=1420449280', 'source': {'id': 'https://openalex.org/S128990672', 'display_name': 'Toxins', 'issn_l': '2072-6651', 'issn': ['2072-6651'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/df430f17cde944e1aa8c16a977370604', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4303811', 'pdf_url': 'https://europepmc.org/articles/pmc4303811?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303811', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25568977', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/toxins7010034', 'pdf_url': 'https://www.mdpi.com/2072-6651/7/1/34/pdf?version=1420449280', 'source': {'id': 'https://openalex.org/S128990672', 'display_name': 'Toxins', 'issn_l': '2072-6651', 'issn': ['2072-6651'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'display_name': 'Life below water', 'score': 0.56}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1975393528', 'https://openalex.org/W1979404035', 'https://openalex.org/W1983423577', 'https://openalex.org/W1997550667', 'https://openalex.org/W2001708290', 'https://openalex.org/W2001908368', 'https://openalex.org/W2007903275', 'https://openalex.org/W2013674343', 'https://openalex.org/W2016816104', 'https://openalex.org/W2019310318', 'https://openalex.org/W2022287706', 'https://openalex.org/W2036830656', 'https://openalex.org/W2043457126', 'https://openalex.org/W2071576293', 'https://openalex.org/W2082270598', 'https://openalex.org/W2091409101', 'https://openalex.org/W2091493579', 'https://openalex.org/W2091788869', 'https://openalex.org/W2096116156', 'https://openalex.org/W2103069276', 'https://openalex.org/W2124725518', 'https://openalex.org/W2127099632', 'https://openalex.org/W2129724588', 'https://openalex.org/W2130930961', 'https://openalex.org/W2153850189', 'https://openalex.org/W2159304491', 'https://openalex.org/W2163659831'], 'related_works': ['https://openalex.org/W4388931040', 'https://openalex.org/W4246446477', 'https://openalex.org/W2358007249', 'https://openalex.org/W2341159917', 'https://openalex.org/W2265813114', 'https://openalex.org/W2061594008', 'https://openalex.org/W2053891472', 'https://openalex.org/W2026685231', 'https://openalex.org/W2005317840', 'https://openalex.org/W1977628516'], 'abstract_inverted_index': {'The': [0], 'potassium': [1, 21, 40, 65, 150, 169], 'channels': [2, 94], 'were': [3], 'recently': [4], 'found': [5, 68, 108], 'to': [6, 125, 163], 'be': [7, 164], 'inhibited': [8], 'by': [9, 133], 'animal': [10, 134], 'toxin-like': [11], 'human': [12], 'β-defensin': [13], '2': [14], '(hBD2),': [15], 'the': [16, 39, 43, 52, 96, 117, 126, 143], 'first': [17, 44], 'defensin': [18, 27, 45], 'blocker': [19, 46], 'of': [20, 98, 113, 120, 129, 146, 168], 'channels.': [22], 'Whether': [23], 'there': [24], 'are': [25], 'other': [26], 'blockers': [28], 'from': [29, 47, 158], 'different': [30, 159], 'organisms': [31, 160], 'remains': [32], 'an': [33], 'open': [34], 'question.': [35], 'Here,': [36], 'we': [37, 67, 107], 'reported': [38], 'channel-blocking': [41], 'plectasin,': [42, 121], 'a': [48, 149, 165], 'fungus.': [49], 'Based': [50], 'on': [51, 64], 'similar': [53, 124], 'cysteine-stabilized': [54], 'alpha-beta': [55], '(CSαβ)': [56], 'structure': [57], 'between': [58], 'plectasin': [59, 70, 83, 147], 'and': [60, 92, 103], 'scorpion': [61], 'toxins': [62], 'acting': [63], 'channels,': [66], 'that': [69, 109, 156], 'could': [71, 84], 'dose-dependently': [72], 'block': [73], 'Kv1.3': [74, 81, 114, 130], 'channel': [75, 104, 115, 131, 151, 170], 'currents': [76], 'through': [77], 'electrophysiological': [78], 'experiments.': [79], 'Besides': [80], 'channel,': [82], 'less': [85], 'inhibit': [86], 'Kv1.1,': [87], 'Kv1.2,': [88], 'IKCa,': [89], 'SKCa3,': [90], 'hERG': [91], 'KCNQ': [93], 'at': [95], 'concentration': [97], '1': [99], 'μΜ.': [100], 'Using': [101], 'mutagenesis': [102], 'activation': [105], 'experiments,': [106], 'outer': [110], 'pore': [111], 'region': [112], 'was': [116], 'binding': [118], 'site': [119, 128], 'which': [122], 'is': [123], 'interacting': [127], 'recognized': [132], 'toxin': [135], 'blockers.': [136], 'Together,': [137], 'these': [138], 'findings': [139], 'not': [140], 'only': [141], 'highlight': [142], 'novel': [144, 166], 'function': [145], 'as': [148], 'inhibitor,': [152], 'but': [153], 'also': [154], 'imply': [155], 'defensins': [157], 'functionally': [161], 'evolve': [162], 'kind': [167], 'inhibitors.': [171]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2080352183', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 5}], 'updated_date': '2024-09-11T14:38:09.153864', 'created_date': '2016-06-24'}