Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2080186455', 'doi': 'https://doi.org/10.1007/s00213-008-1345-y', 'title': 'Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions', 'display_name': 'Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions', 'publication_year': 2008, 'publication_date': '2008-10-09', 'ids': {'openalex': 'https://openalex.org/W2080186455', 'doi': 'https://doi.org/10.1007/s00213-008-1345-y', 'mag': '2080186455', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18843481'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00213-008-1345-y', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80334769', 'display_name': 'Psychopharmacology', 'issn_l': '0033-3158', 'issn': ['0033-3158', '1432-2072'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040096008', 'display_name': 'Christian Brabant', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157674565', 'display_name': 'University of Liège', 'ror': 'https://ror.org/00afp2z80', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I157674565']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Christian Brabant', 'raw_affiliation_strings': ['Centre de Neurosciences Cognitives et Comportementales (CNCC), Université de Liège, Boulevard du Rectorat 5/B-32, 4000 Liège, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Centre de Neurosciences Cognitives et Comportementales (CNCC), Université de Liège, Boulevard du Rectorat 5/B-32, 4000 Liège, Belgium.', 'institution_ids': ['https://openalex.org/I157674565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074120274', 'display_name': 'Livia Alleva', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Livia Alleva', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010621919', 'display_name': 'Thierry Grisar', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Thierry Grisar', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005283286', 'display_name': 'Étienne Quertemont', 'orcid': 'https://orcid.org/0000-0002-9859-0779'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Etienne Quertemont', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044458916', 'display_name': 'Bernard Lakaye', 'orcid': 'https://orcid.org/0000-0002-3850-2175'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bernard Lakaye', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074167675', 'display_name': 'Hiroshi Ohtsu', 'orcid': 'https://orcid.org/0000-0003-3261-8828'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Ohtsu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031778575', 'display_name': 'Jian‐Sheng Lin', 'orcid': 'https://orcid.org/0000-0002-2004-6079'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jian-Sheng Lin', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090692423', 'display_name': 'Peter Jatlow', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Peter Jatlow', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020907559', 'display_name': 'Marina R. Picciotto', 'orcid': 'https://orcid.org/0000-0002-4404-1280'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Marina R Picciotto', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009992550', 'display_name': 'Ezio Tirelli', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ezio Tirelli', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.913, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 52, 'citation_normalized_percentile': {'value': 0.878392, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '202', 'issue': '4', 'first_page': '673', 'last_page': '687'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11346', 'display_name': 'Role of Mast Cells in Immunoregulation and Disease', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11346', 'display_name': 'Role of Mast Cells in Immunoregulation and Disease', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10056', 'display_name': 'Neurobiological Mechanisms of Drug Addiction and Depression', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thioperamide', 'display_name': 'Thioperamide', 'score': 0.99529266}, {'id': 'https://openalex.org/keywords/histaminergic', 'display_name': 'Histaminergic', 'score': 0.9586538}, {'id': 'https://openalex.org/keywords/inverse-agonist', 'display_name': 'Inverse agonist', 'score': 0.5590458}, {'id': 'https://openalex.org/keywords/dopamine', 'display_name': 'Dopamine', 'score': 0.48958}], 'concepts': [{'id': 'https://openalex.org/C2778997900', 'wikidata': 'https://www.wikidata.org/wiki/Q7784686', 'display_name': 'Thioperamide', 'level': 5, 'score': 0.99529266}, {'id': 'https://openalex.org/C2778501154', 'wikidata': 'https://www.wikidata.org/wiki/Q18349602', 'display_name': 'Histaminergic', 'level': 3, 'score': 0.9586538}, {'id': 'https://openalex.org/C63180777', 'wikidata': 'https://www.wikidata.org/wiki/Q288395', 'display_name': 'Histamine H3 receptor', 'level': 4, 'score': 0.8993395}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.6615762}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.608428}, {'id': 'https://openalex.org/C89951826', 'wikidata': 'https://www.wikidata.org/wiki/Q1671731', 'display_name': 'Inverse agonist', 'level': 4, 'score': 0.5590458}, {'id': 'https://openalex.org/C1122143', 'wikidata': 'https://www.wikidata.org/wiki/Q61233', 'display_name': 'Histamine', 'level': 2, 'score': 0.5494331}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4936727}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.2678908}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1446746}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.061302513}], 'mesh': [{'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D006632', 'descriptor_name': 'Histamine', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017442', 'descriptor_name': 'Histamine Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009043', 'descriptor_name': 'Motor Activity', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019540', 'descriptor_name': 'Area Under Curve', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006632', 'descriptor_name': 'Histamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017442', 'descriptor_name': 'Histamine Agonists', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D017442', 'descriptor_name': 'Histamine Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006636', 'descriptor_name': 'Histamine Release', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006636', 'descriptor_name': 'Histamine Release', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009043', 'descriptor_name': 'Motor Activity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018100', 'descriptor_name': 'Receptors, Histamine H3', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018100', 'descriptor_name': 'Receptors, Histamine H3', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018100', 'descriptor_name': 'Receptors, Histamine H3', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D018100', 'descriptor_name': 'Receptors, Histamine H3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00213-008-1345-y', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80334769', 'display_name': 'Psychopharmacology', 'issn_l': '0033-3158', 'issn': ['0033-3158', '1432-2072'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18843481', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1601979337', 'https://openalex.org/W1664200544', 'https://openalex.org/W1974413419', 'https://openalex.org/W1980571433', 'https://openalex.org/W1984360654', 'https://openalex.org/W1988032261', 'https://openalex.org/W1990368217', 'https://openalex.org/W1991607977', 'https://openalex.org/W1991641789', 'https://openalex.org/W1993068126', 'https://openalex.org/W1993640624', 'https://openalex.org/W1995291346', 'https://openalex.org/W2001611980', 'https://openalex.org/W2006610796', 'https://openalex.org/W2013291672', 'https://openalex.org/W2016805373', 'https://openalex.org/W2021876207', 'https://openalex.org/W2034813653', 'https://openalex.org/W2041658692', 'https://openalex.org/W2044307606', 'https://openalex.org/W2046384382', 'https://openalex.org/W2049738964', 'https://openalex.org/W2050248755', 'https://openalex.org/W2058159881', 'https://openalex.org/W2059581034', 'https://openalex.org/W2064144048', 'https://openalex.org/W2066796472', 'https://openalex.org/W2067695260', 'https://openalex.org/W2075212681', 'https://openalex.org/W2076514006', 'https://openalex.org/W2077687762', 'https://openalex.org/W2081513378', 'https://openalex.org/W2091675335', 'https://openalex.org/W2092781217', 'https://openalex.org/W2094605937', 'https://openalex.org/W2097057470', 'https://openalex.org/W2098574165', 'https://openalex.org/W2102960558', 'https://openalex.org/W2115161387', 'https://openalex.org/W2140122537', 'https://openalex.org/W2142943987', 'https://openalex.org/W2314925110', 'https://openalex.org/W2346876587', 'https://openalex.org/W2414497755', 'https://openalex.org/W2417990063', 'https://openalex.org/W2460720990'], 'related_works': ['https://openalex.org/W4230359372', 'https://openalex.org/W2602319162', 'https://openalex.org/W2414644026', 'https://openalex.org/W2089047002', 'https://openalex.org/W2083612072', 'https://openalex.org/W2080186455', 'https://openalex.org/W2057132663', 'https://openalex.org/W2014603114', 'https://openalex.org/W1998488929', 'https://openalex.org/W1980018895'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2080186455', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-09-09T19:22:13.617992', 'created_date': '2016-06-24'}