Publication Information

{'id': 'https://openalex.org/W2080101736', 'doi': 'https://doi.org/10.1074/jbc.272.22.14001', 'title': 'Preferential Modification of Nuclear Proteins by a Novel Ubiquitin-like Molecule', 'display_name': 'Preferential Modification of Nuclear Proteins by a Novel Ubiquitin-like Molecule', 'publication_year': 1997, 'publication_date': '1997-05-01', 'ids': {'openalex': 'https://openalex.org/W2080101736', 'doi': 'https://doi.org/10.1074/jbc.272.22.14001', 'mag': '2080101736', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9162015'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.22.14001', 'pdf_url': 'http://www.jbc.org/article/S0021925819624993/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819624993/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008524978', 'display_name': 'Tetsu Kamitani', 'orcid': 'https://orcid.org/0000-0002-3257-9630'}, 'institutions': [{'id': 'https://openalex.org/I919571938', 'display_name': 'The University of Texas Health Science Center at Houston', 'ror': 'https://ror.org/03gds6c39', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I919571938']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tetsu Kamitani', 'raw_affiliation_strings': ['The University of Texas Health Science Center at Houston, Houston, United States'], 'affiliations': [{'raw_affiliation_string': 'The University of Texas Health Science Center at Houston, Houston, United States', 'institution_ids': ['https://openalex.org/I919571938']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100834753', 'display_name': 'Hung Phi Nguyen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I919571938', 'display_name': 'The University of Texas Health Science Center at Houston', 'ror': 'https://ror.org/03gds6c39', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I919571938']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hung Phi Nguyen', 'raw_affiliation_strings': ['The University of Texas Health Science Center at Houston, Houston, United States'], 'affiliations': [{'raw_affiliation_string': 'The University of Texas Health Science Center at Houston, Houston, United States', 'institution_ids': ['https://openalex.org/I919571938']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029897769', 'display_name': 'Edward T.H. 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{'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.067471325}], 'mesh': [{'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025842', 'descriptor_name': 'SUMO-1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.22.14001', 'pdf_url': 'http://www.jbc.org/article/S0021925819624993/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 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'https://openalex.org/W3215252703', 'https://openalex.org/W3147844193', 'https://openalex.org/W2978153057', 'https://openalex.org/W2884371102', 'https://openalex.org/W2493538936', 'https://openalex.org/W2422474779', 'https://openalex.org/W2377326938', 'https://openalex.org/W2040933678', 'https://openalex.org/W1984446732'], 'abstract_inverted_index': {'Sentrin': [0, 201, 402, 508, 1702], 'is': [1, 55, 72, 94, 121, 197, 202, 256, 273, 295, 322, 398, 578, 659, 669, 684, 698, 878, 930, 937, 947, 980, 1006, 1026, 1703, 1742, 2238, 2420, 2572, 2639, 2765, 2774, 2847, 2886, 2918, 2953, 3067, 3092, 3140, 3150, 3162, 3239, 3272, 3307, 3346, 3436, 3500, 3610, 3633, 3645, 3692, 3700], 'a': [2, 29, 33, 69, 189, 203, 230, 234, 270, 390, 407, 547, 650, 673, 687, 737, 800, 898, 940, 993, 1035, 1041, 1139, 1225, 1401, 1546, 1704, 1797, 1833, 1886, 1892, 1931, 2016, 2066, 2085, 2288, 2312, 2475, 2510, 2522, 2542, 2573, 2712, 2722, 2790, 2977, 2993, 3062, 3072, 3163, 3308, 3357, 3467, 3503, 3536, 3548, 3555, 3639, 3649], 'novel': [3, 190, 204, 391, 1705, 3063, 3556], 'ubiquitin-like': [4, 205, 888, 983, 3064, 3472], 'protein': [5, 194, 206, 395, 559, 564, 705, 731, 885, 984, 1013, 1706, 2896, 3065, 3537], 'that': [6, 57, 71, 89, 118, 207, 258, 272, 290, 319, 759, 946, 978, 985, 1000, 1707, 1920, 2166, 2199, 2232, 2293, 2350, 2382, 2532, 2570, 2703, 2762, 2948, 2958, 3061, 3133, 3352, 3382, 3505, 3613, 3638, 3697], 'protects': [7, 208, 488], 'cells': [8, 87, 209, 288, 489, 1069, 1330, 1343, 1398, 1427, 1478, 1491, 1637, 2035, 2081, 2108, 2601, 2647, 2772, 2934, 3114], 'against': [9, 210, 490, 1248, 1784, 1984], 'both': [10, 211, 491, 2630], 'anti-Fas': [11, 212, 492], 'and': [12, 37, 113, 129, 156, 213, 238, 314, 330, 357, 493, 532, 815, 929, 1055, 1067, 1077, 1103, 1110, 1222, 1278, 1412, 1442, 1486, 1529, 1567, 1592, 1623, 1651, 1677, 1697, 1745, 1764, 1792, 1891, 2039, 2091, 2105, 2150, 2249, 2374, 2404, 2448, 2486, 2562, 2594, 2615, 2634, 2654, 2657, 2688, 2729, 2808, 2871, 2925, 3032, 3083, 3107, 3197, 3200, 3314, 3428, 3553, 3601, 3616, 3742], 'tumor': [13, 214, 447, 552], 'necrosis': [14, 215, 448, 455, 553], 'factor-induced': [15, 216], 'cell': [16, 114, 217, 315, 495, 511, 810, 1202, 1835, 1857, 1903, 1972, 1975, 2018, 2041, 2141, 2159, 2179, 2779, 2792], 'death.': [17, 218, 496], 'Antiserum': [18, 219], 'recognizing': [19, 220], 'the': [20, 26, 46, 51, 75, 90, 106, 125, 130, 140, 143, 160, 175, 183, 221, 227, 247, 252, 276, 291, 307, 326, 331, 341, 344, 361, 376, 384, 413, 475, 516, 519, 643, 711, 715, 719, 729, 734, 807, 880, 1001, 1032, 1121, 1147, 1315, 1339, 1360, 1368, 1436, 1538, 1595, 1612, 1629, 1660, 1738, 1761, 1770, 1776, 1785, 1814, 1843, 1847, 1867, 1883, 1912, 1917, 1985, 2008, 2103, 2145, 2157, 2177, 2186, 2201, 2235, 2245, 2296, 2307, 2316, 2320, 2361, 2369, 2393, 2400, 2405, 2414, 2417, 2430, 2434, 2484, 2538, 2547, 2559, 2577, 2632, 2635, 2643, 2668, 2677, 2685, 2689, 2696, 2716, 2730, 2748, 2754, 2785, 2809, 2824, 2842, 2851, 2859, 2862, 2867, 2878, 2881, 2889, 2922, 2930, 2944, 2967, 2981, 2989, 2998, 3001, 3078, 3086, 3101, 3134, 3148, 3166, 3242, 3247, 3278, 3282, 3343, 3350, 3361, 3366, 3378, 3389, 3416, 3426, 3432, 3443, 3452, 3463, 3541, 3583, 3594, 3695, 3703, 3730], 'N': [21, 222, 1148, 1762, 2755, 2825], 'terminus': [22, 93, 223, 294, 1003, 1149, 1763, 1772, 1919, 2191, 2322, 2756, 2828, 2844, 2883], 'of': [23, 28, 63, 80, 132, 147, 177, 224, 229, 264, 281, 333, 348, 378, 416, 478, 499, 501, 518, 543, 634, 642, 663, 680, 689, 714, 718, 724, 736, 743, 809, 901, 943, 1004, 1018, 1034, 1046, 1081, 1125, 1150, 1200, 1215, 1299, 1501, 1587, 1611, 1618, 1631, 1647, 1670, 1692, 1778, 1813, 1866, 1873, 1894, 1967, 1990, 2010, 2076, 2087, 2096, 2185, 2192, 2234, 2242, 2294, 2309, 2383, 2392, 2402, 2416, 2424, 2433, 2437, 2452, 2497, 2551, 2579, 2592, 2718, 2725, 2757, 2787, 2829, 2845, 2861, 2869, 2880, 2884, 2891, 2932, 2960, 2969, 2983, 2997, 3000, 3081, 3103, 3165, 3267, 3281, 3305, 3336, 3363, 3370, 3454, 3502, 3508, 3543, 3586, 3634, 3642, 3647, 3732, 3748], 'sentrin': [24, 31, 44, 64, 83, 91, 119, 148, 154, 225, 232, 245, 265, 284, 292, 320, 349, 355, 487, 502, 535, 979, 1005, 1044, 1300, 1741, 1754, 1779, 1828, 1844, 1868, 1874, 1910, 1968, 1991, 2011, 2023, 2029, 2147, 2154, 2193, 2284, 2313, 2332, 2425, 2481, 2539, 2552, 2560, 2580, 2593, 2690, 2704, 2763, 2788, 2800, 2832, 2846, 2885, 2923, 3364, 3384, 3429, 3587, 3733], 'revealed': [25, 226, 2084, 2143], 'presence': [27, 228, 1033, 2415, 3102], '18-kDa': [30, 231, 1824, 1838, 1848, 1884, 2146], 'monomer,': [32, 233, 2089, 2148, 2789], '90-kDa': [34, 235, 1888], 'band': [35, 236, 1825, 1839, 1849, 1889, 2524], '(p90),': [36, 237], 'multiple': [38, 239], 'high': [39, 161, 178, 240, 362, 379, 1895, 2375, 2406, 2498, 2583, 2669, 2731, 2872, 2961, 2984, 3337], 'molecular': [40, 162, 179, 241, 363, 380, 882, 1896, 2152, 2376, 2407, 2499, 2584, 2670, 2732, 2873, 2962, 2985, 3338], 'mass': [41, 163, 180, 242, 364, 381, 1897, 2153, 2377, 2408, 2500, 2585, 2671, 2733, 2874, 2963, 2986, 3339], 'bands.': [42, 243, 2875, 2987], 'Because': [43, 244], 'possesses': [45, 246], 'conserved': [47, 107, 144, 248, 308, 345, 644], 'Gly-Gly': [48, 145, 249, 346, 1914, 2203, 2436, 2533], 'residues': [49, 146, 250, 347, 1915, 2204], 'near': [50, 251, 1916], 'C': [52, 92, 253, 293, 1002, 1771, 1918, 2190, 2321, 2827, 2843, 2882], 'terminus,': [53, 254], 'it': [54, 98, 255, 299, 1923, 2956], 'likely': [56, 257, 1841], 'these': [58, 259, 2740], 'additional': [59, 260, 2950], 'bands': [60, 164, 181, 261, 365, 382, 1898, 2409, 2501, 2672], 'represent': [61, 262], 'conjugation': [62, 263, 945, 1872, 2289, 2423, 2451, 2550, 2578, 3002], 'to': [65, 74, 99, 102, 124, 136, 139, 151, 171, 266, 275, 300, 303, 325, 337, 340, 352, 372, 525, 528, 550, 583, 636, 672, 686, 702, 728, 755, 798, 894, 897, 949, 989, 996, 1039, 1049, 1120, 1142, 1205, 1224, 1536, 1564, 1608, 1748, 1752, 1794, 1810, 1816, 1863, 1875, 1882, 1924, 1927, 1934, 2165, 2244, 2251, 2285, 2292, 2302, 2319, 2381, 2426, 2439, 2444, 2454, 2534, 2553, 2581, 2642, 2708, 2715, 2744, 2747, 2888, 3070, 3094, 3142, 3153, 3156, 3277, 3365, 3423, 3425, 3430, 3438, 3457, 3625, 3636], 'other': [66, 103, 267, 304, 544, 637, 990, 1856, 1876, 1928, 2427, 2455, 2554, 2582, 2709, 2778, 2972, 3447, 3626], 'proteins': [67, 104, 134, 268, 305, 335, 545, 582, 638, 903, 991, 1020, 1048, 1268, 1877, 1929, 2252, 2456, 2586, 2596, 2710, 2727, 2742, 2811, 2965, 3082, 3341, 3628], 'in': [68, 85, 182, 269, 286, 383, 406, 484, 546, 676, 745, 803, 806, 812, 816, 992, 1088, 1269, 1405, 1414, 1498, 1644, 1780, 1796, 1820, 1831, 1855, 1901, 1930, 1970, 2013, 2070, 2102, 2106, 2172, 2287, 2480, 2519, 2537, 2576, 2622, 2631, 2664, 2676, 2695, 2711, 2770, 2777, 2823, 2838, 2850, 2929, 2943, 2980, 3112, 3137, 3241, 3311, 3342, 3360, 3540, 3547], 'manner': [70, 271, 2713], 'similar': [73, 274, 549, 1747, 2164, 2380, 2476, 2714], 'ubiquitination': [76, 277, 794, 950, 1935, 2097], 'pathway.': [77, 278], 'Transient': [78, 279], 'expression': [79, 280, 1777, 1969, 2019, 2370, 2401, 2496, 2793], 'hemagglutinin': [81, 282, 555, 1127], 'epitope-tagged': [82, 283], 'mutants': [84, 285, 1301, 2024], 'COS': [86, 287, 2017, 2034, 2080, 2158, 2178, 2330, 2600, 2646, 2791, 2806, 3113], 'demonstrated': [88, 117, 289, 318], 'cleaved,': [95, 296], 'which': [96, 196, 297, 397, 1009, 1025, 3499, 3603, 3653], 'allows': [97, 298, 1010], 'be': [100, 137, 172, 301, 338, 373, 584, 750, 761, 895, 987, 1040, 1852, 1861, 1925, 2303, 2336, 2344, 2628, 2706, 2976, 3130, 3605], 'conjugated': [101, 302, 896, 988, 1926, 2707], 'via': [105, 306], 'C-terminal': [108, 309, 645, 1279, 2297, 2310, 2351, 2362, 2418, 2435, 2863, 2898], 'Gly': [109, 310, 646, 2236], 'residue.': [110, 311], 'Immunocytochemical': [111, 312, 1355], 'staining': [112, 313, 1356], 'fractionation': [115, 316], 'analysis': [116, 317, 1966, 2075], 'monomer': [120, 155, 321, 356, 1869, 2333, 2485, 2561, 2764, 2924], 'localized': [122, 138, 323, 339, 3240], 'predominantly': [123, 324], 'cytosol.': [126, 327, 2697], 'However,': [127, 328, 1846, 2518, 2988, 3147], 'p90': [128, 157, 168, 329, 358, 369, 1037, 2403, 2487, 2563, 2571, 2680, 2870, 2926, 2974, 3108, 3135, 3353], 'majority': [131, 332], 'sentrinized': [133, 334, 2595, 2741, 2964, 3110, 3143, 3340, 3386, 3621, 3627, 3698], 'appeared': [135, 336], 'nucleus.': [141, 184, 342, 385, 2636, 2749, 3433], 'When': [142, 343, 482, 2325, 2360, 2474], 'were': [149, 165, 350, 366, 1057, 1070, 1086, 1260, 1282, 1287, 1302, 1323, 1331, 1344, 1403, 1428, 1479, 1492, 1638, 1899, 1977, 2043, 2366, 2488, 2507, 2564, 2602, 2648, 2673, 2692, 2803, 2812, 2927, 2940], 'changed': [150, 351], 'Gly-Ala,': [152, 353], 'only': [153, 354, 881, 2144, 2483, 2558, 2721, 2921], 'but': [158, 359, 472, 2341, 2773, 3244, 3622], 'not': [159, 360, 473, 504, 879, 1851, 1907, 2335, 2411, 2775, 3619], 'observed.': [166, 367, 2528, 2566, 2954], 'Thus,': [167, 368, 2156, 2413, 2955, 3303], 'generation': [169, 370], 'appears': [170, 371, 1038, 2957], 'required': [173, 374, 3076, 3437], 'for': [174, 192, 375, 393, 580, 763, 884, 939, 1011, 1043, 1192, 1274, 1295, 1346, 1409, 1418, 1533, 1561, 1577, 1655, 1682, 1827, 2049, 2240, 2283, 2422, 2753, 2866, 3004, 3077, 3100, 3274, 3319, 3368, 3745], 'formation': [176, 377, 2868, 2959, 2968, 2982], 'Taken': [185, 386, 2876], 'together,': [186, 387, 2877], 'sentrinization': [187, 388, 3304], 'represents': [188, 389, 1842], 'pathway': [191, 392, 942, 2290], 'nuclear': [193, 394, 1019, 1047, 1632, 1700, 2655, 2678, 2686, 3087, 3283, 3312, 3371, 3379, 3390, 3417], 'modification,': [195, 396], 'distinct': [198, 399, 941, 1028], 'from': [199, 400, 665, 700, 726, 1029, 1059, 1073, 2079, 2509, 3246, 3385], 'ubiquitination.': [200, 401, 551, 997, 1030, 2719], 'was': [403, 1134, 1154, 1190, 1210, 1236, 1357, 1454, 1542, 1555, 1571, 1582, 1600, 1665, 1687, 1790, 1803, 1829, 1906, 2025, 2031, 2063, 2323, 2327, 2379, 2478, 2526, 2597, 2681, 2795, 2820, 3009], 'originally': [404], 'isolated': [405], 'yeast': [408, 2104, 3549, 3640], 'two': [409, 926, 1272, 3446, 3550], 'hybrid': [410, 3551], 'screen': [411, 3552], 'using': [412, 1238, 1308, 1338, 1367, 1545, 1982, 2021, 2053, 3462], 'death': [414, 470, 476, 512], 'domain': [415, 471, 477, 1711], 'Fas': [417], 'as': [418, 1195, 1262, 1376, 1456, 1481, 1594, 1625, 1699, 2065, 2610, 3466, 3593], 'bait': [419], '(1Okura': [420, 1164, 1714, 2205], 'T.': [421, 425, 427, 1165, 1169, 1171, 1380, 1460, 1715, 1719, 1721, 2206, 2210, 2212, 3041], 'Gong': [422, 1166, 1716, 2207], 'L.': [423, 840, 846, 1167, 1717, 2208, 3043, 3662], 'Kamitani': [424, 1168, 1718, 2209], 'Wada': [426, 1170, 1720, 2211], 'Okura': [428, 1172, 1722, 2213], 'I.': [429, 1173, 1723, 2214], 'Wei': [430, 1174, 1724, 2215], 'C.K.': [431, 1175, 1725, 2216], 'Chang': [432, 1176, 1726, 2217], 'H.M.': [433, 1177, 1727, 2218, 3252], 'Yeh': [434, 1178, 1728, 2219], 'E.T.H.': [435, 1179, 1729, 2220], 'J.': [436, 912, 952, 957, 1180, 1730, 2221, 2463, 3021, 3170, 3255, 3292, 3403, 3665, 3715], 'Immunol.': [437, 1181, 1386, 1466, 1731, 2222], '1996;': [438, 597, 822, 960, 1182, 1732, 2223, 3024, 3295, 3327, 3406, 3486, 3523, 3572, 3718], '157:': [439, 1183, 1733, 2224], '4277-4281PubMed': [440, 1184, 1734, 2225], 'Google': [441, 603, 618, 631, 789, 833, 861, 875, 922, 971, 1185, 1394, 1474, 1735, 1949, 1962, 2122, 2135, 2226, 2266, 2279, 2472, 2913, 3030, 3058, 3195, 3219, 3235, 3264, 3301, 3333, 3412, 3492, 3529, 3575, 3674, 3689, 3724], 'Scholar).': [442, 632, 790, 876, 923, 972, 1186, 1395, 1475, 1736, 2136, 2227, 2280, 2473, 2914, 3236, 3265, 3302, 3334, 3413, 3493, 3530, 3576, 3690, 3725], 'It': [443, 2228, 3609, 3632], 'also': [444, 749, 2527, 2941, 3097, 3394, 3450, 3495, 3611], 'interacts': [445, 3496], 'with': [446, 474, 678, 710, 1098, 1138, 1157, 1160, 1314, 1333, 1430, 1438, 1443, 1494, 1584, 1602, 1615, 1640, 1689, 1805, 1993, 2315, 2338, 2604, 2617, 2659, 2684, 3117, 3349, 3377, 3497, 3588, 3694, 3702], 'factor': [449, 554], '(TNF)': [450], '1The': [451], 'abbreviations': [452], 'used': [453, 1191, 1261, 1593, 1624, 1698, 2064, 3534], 'are:TNFtumor': [454], 'factorHAhemagglutinin': [456], 'epitopeMBPmaltose': [457], 'binding': [458, 558], 'proteinE1ubiquitin-activating': [459], 'enzymeE2ubiquitin': [460], 'carrier': [461, 563, 691], 'proteinE3ubiquitin-protein': [462], 'isopeptide': [463, 566, 708], 'ligasemAbmonoclonal': [464], 'antibodyHA-UbiquitinHA-tagged': [465], 'ubiquitinHA-SentrinHA-tagged': [466], 'sentrin.': [467, 573, 1151, 1817, 2738, 2835, 3005, 3095, 3458, 3608], 'receptor': [468, 813, 3597], '1': [469, 934, 1206, 1514, 1517, 1520, 1578], 'FADD/MORT1': [479], 'or': [480, 1092, 1162, 1217, 1251, 1318, 1349, 1808, 1870, 1996, 2057, 2549, 2826, 2833], 'CD40.': [481], 'overexpressed': [483], 'mammalian': [485, 982, 2107], 'cells,': [486, 1271, 1781, 2331, 2807], 'TNF-induced': [494], 'The': [497, 722, 740, 1129, 1152, 1187, 1320, 1449, 1553, 1580, 1598, 1663, 1685, 1801, 2189, 2495, 2589, 2818, 2915], 'mechanism': [498, 2991], 'action': [500], 'has': [503, 795, 891, 2098, 2194, 2229, 2441, 2541, 3393, 3654], 'been': [505, 796, 892, 2099, 2230, 2354, 2442, 3395], 'clearly': [506, 1027, 1853, 2857], 'elucidated.': [507], 'could': [509, 536, 1850, 1860, 2334, 2343, 2627, 3604], 'block': [510], 'signaling': [513], 'by': [514, 576, 586, 649, 661, 752, 932, 1023, 1136, 1304, 1312, 1325, 1359, 1435, 1544, 1550, 1659, 1979, 2036, 2168, 2346, 2737, 2814, 2897, 3269, 3607], 'blocking': [515], 'assembly': [517], 'death-inducing': [520], 'signal': [521, 817], 'complex.': [522, 3089], 'Alternatively,': [523], 'due': [524, 1862], 'its': [526, 538, 703, 3275], 'homology': [527], 'ubiquitin': [529, 562, 571, 577, 635, 657, 683, 690, 697, 725, 754, 927, 1710, 1739, 2061, 2088, 2243, 2246, 2438, 2453, 2894], '(18%': [530], 'identical': [531, 1744, 3093, 3141, 3456], '48%': [533, 1746], 'similar),': [534], 'exert': [537], 'anti-death': [539], 'effect': [540, 2544], 'through': [541, 694, 706, 3629], 'modification': [542, 575, 1045, 2012, 3369], 'process': [548, 994, 1932, 2717, 3003], 'epitope': [556], 'maltose': [557], 'ubiquitin-activating': [560, 652], 'enzyme': [561], 'ubiquitin-protein': [565], 'ligase': [567], 'monoclonal': [568, 1117], 'antibody': [569, 1432, 2056], 'HA-tagged': [570, 572, 1267, 2022, 2028, 2060, 2799, 3119], 'Protein': [574], 'critical': [579, 801, 2239, 3358, 3746], 'targeting': [581], 'degraded': [585], 'proteasomes': [587], '(2Coux': [588], 'O.': [589], 'Tanaka': [590], 'K.': [591, 842, 3223, 3563], 'Goldberg': [592, 849], 'A.L.': [593, 850, 905, 956], 'Annu.': [594, 609, 622, 1940, 1953, 2113, 2126, 2257, 2270, 2904], 'Rev.': [595, 610, 623, 1941, 1954, 2114, 2127, 2258, 2271, 2905], 'Biochem.': [596, 611, 1942, 2115, 2259, 2906], '65:': [598], '801-847Crossref': [599], 'PubMed': [600, 615, 628, 786, 830, 858, 872, 921, 968, 1391, 1471, 1946, 1959, 2119, 2132, 2263, 2276, 2910, 3027, 3055, 3192, 3216, 3232, 3261, 3298, 3330, 3409, 3489, 3526, 3671, 3686, 3721], 'Scopus': [601, 616, 629, 787, 831, 859, 873, 969, 1392, 1472, 1947, 1960, 2120, 2133, 2264, 2277, 2911, 3028, 3056, 3193, 3217, 3233, 3262, 3299, 3331, 3410, 3490, 3527, 3672, 3687, 3722], '(2235)': [602], 'Scholar,': [604, 619, 834, 862, 1950, 2123, 2267, 3675], '3Hershko': [605], 'A.': [606, 608, 864, 1937, 1939, 2110, 2112, 2254, 2256, 2901, 2903, 3172], 'Ciechanover': [607, 1938, 2111, 2255, 2902], '1992;': [612, 625, 1943, 1956, 2116, 2129, 2260, 2273, 2466, 2907], '61:': [613, 1944, 2117, 2261, 2908], '761-807Crossref': [614, 1945, 2118, 2262, 2909], '(1205)': [617, 1948, 2121, 2265, 2912], '4Jentsch': [620, 1951, 2124, 2268], 'S.': [621, 769, 1384, 1464, 1952, 2125, 2269], 'Genet.': [624, 1955, 2128, 2272], '26:': [626, 1957, 2130, 2274], '179-207Crossref': [627, 1958, 2131, 2275], '(450)': [630, 1961, 2134, 2278], 'Conjugation': [633], 'requires': [639, 2966], 'initial': [640], 'activation': [641, 2233], 'residue': [647, 717, 2237, 2396, 2865], 'catalyzed': [648], 'specific': [651, 1826, 2752], 'enzyme,': [653], 'E1.': [654], 'An': [655], 'intermediate,': [656], 'adenylate,': [658], 'formed': [660], 'displacement': [662], 'PPi': [664], 'ATP.': [666], 'Ubiquitin': [667, 877], 'adenylate': [668], 'then': [670, 2649], 'transferred': [671, 685, 699, 1223], 'thiol': [674], 'site': [675], 'E1': [677], 'release': [679], 'AMP.': [681], 'Next,': [682], 'family': [688], 'proteins,': [692, 3591], 'E2,': [693], 'transacylation.': [695], 'Finally,': [696], 'E2': [701, 727], 'target': [704, 720, 730], 'an': [707, 1709, 1823, 2949, 3118, 3471], 'linkage': [709], 'ε-amino': [712], 'group': [713], 'Lys': [716, 742], 'protein.': [721], 'transfer': [723, 2241], 'may': [732, 760, 2975], 'require': [733], 'participation': [735], 'ligase,': [738], 'E3.': [739], 'internal': [741], 'ubiquitin,': [744, 1753, 2295], 'particular': [746], 'Lys48,': [747], 'can': [748, 986, 2705], 'modified': [751, 1022, 1094, 2736, 3606], 'another': [753, 981], 'form': [756], 'multiubiquitin': [757], 'chains': [758], 'crucial': [762, 3309], 'proteosome': [764], 'recognition': [765], '(5Finley': [766], 'D.': [767, 848, 3323, 3679], 'Sadis': [768], 'Monia': [770], 'B.P.': [771], 'Boucher': [772], 'P.': [773, 907, 3179], 'Ecker': [774], 'D.J.': [775, 3484, 3521], 'Crook': [776], 'E.': [777, 3018, 3289, 3400, 3568, 3712], 'Chau': [778], 'V.': [779, 3225], 'Mol.': [780, 3210, 3226, 3680], 'Cell.': [781, 821, 851, 865, 3046, 3211, 3228, 3682], 'Biol.': [782, 913, 958, 2464, 3023, 3212, 3227, 3257, 3294, 3405, 3667, 3681, 3717], '1994;': [783, 852, 3189], '14:': [784], '5501-5509Crossref': [785], '(303)': [788], 'In': [791, 973, 1737, 1750, 1880, 2137, 2175, 2281, 2429, 2556, 2637, 2698, 2971, 3442], 'recent': [792], 'years,': [793], 'shown': [797, 893, 1819, 2069, 2171, 2231, 2443, 2621, 2663, 2761, 2837], 'play': [799], 'role': [802, 3359], 'antigen': [804], 'processing,': [805, 2311], 'regulation': [808], 'cycle,': [811], 'endocytosis,': [814], 'transduction': [818], '(6Hochstrasser': [819], 'M.': [820], '84:': [823], '813-815Abstract': [824], 'Full': [825, 827, 855, 869, 918, 963, 965, 2469, 3050, 3052], 'Text': [826, 828, 856, 870, 919, 964, 966, 2470, 3051, 3053], 'PDF': [829, 857, 871, 920, 967, 2471, 3054], '(243)': [832], '7Rock': [835], 'K.L.': [836], 'Gramm': [837], 'C.': [838, 3039], 'Rothstein': [839], 'Clark': [841], 'Stein': [843], 'R.': [844, 3037], 'Dick': [845], 'Hwang': [847], '78:': [853], '761-771Abstract': [854], '(2197)': [860], '8Murray': [863], '1995;': [866, 3683], '81:': [867], '149-152Abstract': [868], '(275)': [874], 'tag': [883], 'modification.': [886, 3734], 'Another': [887], 'protein,': [889, 3473], 'UCRP,': [890], 'large': [899], 'number': [900, 2724], 'intracellular': [902], '(9Haas': [904], 'Ahrens': [906], 'Bright': [908], 'P.M.': [909], 'Ankel': [910], 'H.': [911, 1382, 1462, 3175, 3177], 'Chem.': [914, 959, 2465], '1987;': [915], '262:': [916], '11315-11323Abstract': [917], 'UCRP': [924, 944], 'contains': [925, 1708, 1755], 'domains': [928], 'inducible': [931], 'type': [933, 2831], 'interferons.': [935], 'There': [936], 'evidence': [938, 3099], 'parallel': [948], '(10Narasimhan': [951], 'Potter': [953], 'J.L.': [954], 'Haas': [955], '271:': [961, 3328], '324-330Abstract': [962], '(125)': [970], 'this': [974, 2699, 3007, 3138, 3158, 3440, 3749], 'communication,': [975, 2700], 'we': [976, 2701, 2759, 3128], 'show': [977, 999, 2702], 'analogous': [995, 1933, 2291, 2887], 'We': [998, 3096, 3735], 'efficiently': [1007, 2848], 'processed,': [1008], 'subsequent': [1012], 'conjugation.': [1014], 'Furthermore,': [1015], 'limited': [1016, 2723], 'numbers': [1017], 'are': [1021, 1115, 2735, 3618], 'sentrin,': [1024, 2758, 3643], 'Remarkably,': [1031, 2739, 3090], 'sentrin-modified': [1036], 'prerequisite': [1042], 'occur.': [1050], 'Raji,': [1051], 'Jurkat,': [1052], 'HL60,': [1053], 'SW837,': [1054], 'SK-N-SH': [1056, 2771], 'purchased': [1058], 'American': [1060], 'Type': [1061], 'Culture': [1062], 'Collection': [1063], '(Rockville,': [1064], 'MD).': [1065], 'BJAB': [1066], 'COS-M6': [1068, 1270, 1329, 1397, 1477], 'generous': [1071], 'gifts': [1072], 'Drs.': [1074, 3737], 'Fred': [1075], 'Wang': [1076], 'Dr.': [1078], 'Steve': [1079], 'Goldring': [1080], 'Harvard': [1082], 'Medical': [1083], 'School.': [1084], 'Cells': [1085], 'seeded': [1087], 'RPMI': [1089], '1640': [1090], 'medium': [1091, 1096], "Dulbecco's": [1093], "Eagle's": [1095], 'supplemented': [1097], '10%': [1099], 'fetal': [1100], 'calf': [1101], 'serum': [1102], 'antibiotics.': [1104], '12CA5': [1105], '(Boehringer': [1106], 'Mannheim,': [1107], 'Indianapolis,': [1108], 'IN)': [1109], '16B12': [1111], '(BAbCo,': [1112], 'Richmond,': [1113], 'CA)': [1114, 1259, 1294, 1375], 'mouse': [1116, 1249], 'antibodies': [1118, 1247], '(mAbs)': [1119], 'peptide': [1122, 1140], 'sequence': [1123], 'YPYDVPDYA': [1124], 'influenza': [1126], '(HA).': [1128], 'rabbit': [1130, 1252], 'polyclonal': [1131, 1782, 2169], 'anti-sentrin': [1132, 2058, 2347], 'antiserum': [1133, 1153, 1783, 1802, 1983, 2170, 2751], 'generated': [1135, 1303, 1791], 'immunization': [1137], 'corresponding': [1141], 'amino': [1143, 1758, 1767, 1788, 1988, 2196, 2299, 2364], 'acids': [1144, 1759, 1768, 1789, 1989, 2197, 2300, 2365], '1–21': [1145], 'at': [1146, 1421, 1557, 1573, 1679, 1760, 1769, 2767, 3388, 3415], 'incubated': [1155, 1429, 1530, 1652], 'overnight': [1156], 'beads': [1158], 'coated': [1159], 'MBP': [1161, 1807, 1995], 'MBP-sentrin': [1163, 1809], 'preabsorbed': [1188, 1804, 1992], 'supernatant': [1189, 1599], 'Western': [1193, 1234, 1347, 1798, 1980, 2050, 2073, 2815], 'blotting': [1194, 1235, 1348, 1981], 'described': [1196, 1377, 2611], 'below.': [1197], '3': [1198, 1488, 1562, 1634, 2357, 2387, 2491, 2514, 2840, 2936], 'μl': [1199, 1586, 1610, 1617, 1691], 'total': [1201, 2040], 'lysate': [1203, 2077, 2142, 2931], '(equivalent': [1204], '×': [1207, 1489, 1559, 1575, 1635], '104': [1208], 'cells)': [1209], 'loaded': [1211], 'on': [1212, 1400, 1531, 1653, 1667, 2545], 'each': [1213], 'lane': [1214, 2389, 2493, 2516], '10': [1216, 1419, 1523, 1683], '12%': [1218], 'polyacrylamide': [1219], 'gel,': [1220], 'electrophoresed,': [1221], 'polyvinylidene': [1226], 'difluoride': [1227], 'membrane,': [1228], 'Immobilon': [1229], 'P': [1230], '(Millipore,': [1231], 'Bedford,': [1232], 'MA).': [1233], 'performed': [1237, 1358, 1455], 'ECL': [1239], 'detection': [1240, 2052, 2184], 'system': [1241, 1372, 2020, 2161, 2181, 2794], '(Amersham': [1242], 'Corp.)': [1243], 'protocol.': [1244], 'Horseradish': [1245], 'peroxidase-conjugated': [1246], 'IgG': [1250, 1253, 1441], '(Santa': [1254], 'Cruz': [1255], 'Biotechnology,': [1256], 'Santa': [1257], 'Cruz,': [1258], 'secondary': [1263], 'antibodies.': [1264], 'To': [1265, 1483, 1774, 2006, 2305, 2783], 'express': [1266], 'vectors': [1273], 'N-terminal': [1275, 1786, 1986], 'tagging': [1276, 1280], '(pcDNA3/HA-N)': [1277], '(pcDNA3/HA-C)': [1281], 'constructed.': [1283], 'HA': [1284], 'adapter': [1285], 'duplexes': [1286], 'inserted': [1288], 'into': [1289, 2033, 2329, 2651, 2805], 'pcDNA3': [1290], '(Invitrogen,': [1291], 'San': [1292], 'Diego,': [1293], 'vector': [1296], 'construction.': [1297], 'cDNAs': [1298], 'polymerase': [1305], 'chain': [1306], 'reaction': [1307], 'appropriate': [1309], 'primers': [1310], 'followed': [1311, 1434, 1549, 1658], 'ligation': [1313], 'vector,': [1316], 'pcDNA3/HA-N': [1317], 'pcDNA3/HA-C.': [1319], 'insert': [1321], 'sequences': [1322], 'confirmed': [1324], 'direct': [1326], 'DNA': [1327, 3509], 'sequencing.': [1328], 'transfected': [1332, 2032, 2328, 2603, 2645, 2804, 2852, 2933, 3116], 'LipofectAMINE': [1334], '(Life': [1335], 'Technologies,': [1336], 'Inc.)': [1337], "manufacturer's": [1340], 'recommendation.': [1341], 'Transfected': [1342, 1396, 1476], 'harvested': [1345], 'immunostaining': [1350], '16': [1351, 2045], 'h': [1352, 2046], 'after': [1353, 2047], 'transfection.': [1354], 'avidin-biotin-horseradish': [1361], 'peroxidase': [1362, 1447], 'complex': [1363, 3285, 3381, 3392, 3419, 3504], '(ABC-horseradish': [1364], 'peroxidase)': [1365], 'method': [1366], 'VECTASTAIN': [1369], 'ABC': [1370, 1444], 'kit': [1371], '(Vector,': [1373], 'Burlingame,': [1374], 'previously': [1378, 1458, 2101], '(11Kamitani': [1379, 1459], 'Suzuki': [1381, 1461], 'Yano': [1383, 1463], 'Clin.': [1385, 1465], 'Immunopathol.': [1387, 1467], '1991;': [1388, 1468], '58:': [1389, 1469], '217-235Crossref': [1390, 1470], '(8)': [1393, 1473], 'grown': [1399], 'coverslip': [1402], 'fixed': [1404, 1426], '3.7%': [1406], 'paraformaldehyde': [1407], 'solution': [1408, 1591, 1696], '20': [1410], 'min': [1411, 1420, 1535, 1563, 1657], 'permeabilized': [1413], '0.1%': [1415], 'Triton': [1416], 'X-100': [1417], 'room': [1422], 'temperature.': [1423], 'After': [1424], 'washing,': [1425], 'anti-HA': [1431, 2055, 2339, 2618, 2660], '(16B12),': [1433], 'incubation': [1437], 'biotinylated': [1439], 'anti-mouse': [1440], 'reagent': [1445], '(avidin-biotin-horseradish': [1446], 'complex).': [1448], 'final': [1450], 'enzymatic': [1451], 'disclosing': [1452], 'procedure': [1453], 'reported': [1457, 3060, 3396, 3451], 'subfractionated': [1480], 'follows.': [1482], 'prepare': [1484], 'S100': [1485, 1626], 'P100,': [1487], '107': [1490, 1636], 'washed': [1493, 1639], 'phosphate-buffered': [1495, 1641], 'saline,': [1496, 1642], 'resuspended': [1497, 1643], '2': [1499, 1645], 'ml': [1500, 1646, 1669], 'hypotonic': [1502, 1648], 'lysis': [1503, 1649, 1671], 'buffer': [1504, 1672], '(5': [1505], 'mmTris-HCl': [1506], '(pH': [1507], '7.4),': [1508], '2.5': [1509], 'mm': [1510, 1515], 'KCl,': [1511], '5': [1512, 1668], 'mmMgCl2,': [1513], 'dithiothreitol,': [1516], 'mmphenylmethylsulfonyl': [1518], 'fluoride,': [1519], 'μg/ml': [1521, 1524], 'leupeptin,': [1522], 'aprotinin,': [1525], '1.5': [1526], 'μm': [1527], 'pepstatin),': [1528], 'ice': [1532, 1654], '15': [1534, 1656], 'swell': [1537], 'cells.': [1539, 1569, 2853], 'Cell': [1540, 3022, 3256, 3293, 3404, 3666, 3716], 'suspension': [1541], 'homogenized': [1543], 'Dounce': [1547, 1661], 'homogenizer': [1548], 'microscopic': [1551], 'evaluation.': [1552], 'homogenate': [1554, 1664], 'centrifuged': [1556, 1572, 1678], '1,000': [1558], 'g': [1560, 1576], 'remove': [1565], 'nucleus': [1566, 3248, 3367], 'undisrupted': [1568], 'Supernatant': [1570], '100,000': [1574], 'h.': [1579], 'pellet': [1581, 1686], 'solubilized': [1583, 1688], '200': [1585, 1690], '2%': [1588, 1693], 'SDS': [1589, 1620, 1694], 'treating': [1590, 1621, 1695], 'P100': [1596], 'fraction.': [1597, 1627, 1701, 2679], 'concentrated': [1601], 'Centricon-10': [1603], '(Amicon,': [1604], 'Beverly,': [1605], 'MA)': [1606], 'up': [1607], '100': [1609, 1616], 'volume,': [1613], 'mixed': [1614], '4%': [1619], 'solution,': [1622], 'For': [1628], 'preparation': [1630], 'fraction,': [1633, 2687], 'buffer,': [1650], 'homogenization.': [1662], 'overlaid': [1666], 'containing': [1673, 2798], '0.5': [1674], 'm': [1675], 'sucrose': [1676], '3,000': [1680], '×g': [1681], 'min.': [1684], '(residues': [1712], '22–97)': [1713], 'domain,': [1740], '18%': [1743], 'ubiquitin.': [1749], 'contrast': [1751], 'extra': [1756], '21': [1757, 1787, 1987], '4': [1765, 2624, 2666], 'more': [1766, 2014, 2994], '(Fig.1).': [1773], 'study': [1775, 2007, 2784], 'put': [1793], 'use': [1795], 'blot': [1799, 1965, 2051, 2074, 2816], 'analysis.': [1800, 2817], 'either': [1806, 1994, 2054, 2546, 2605, 2822], 'demonstrate': [1811, 2858], 'specificity': [1812], 'immunoreactivity': [1815], 'As': [1818, 2068, 2620, 2662, 2836], 'Fig.': [1821, 2173, 2623, 2665, 2839], '2,': [1822], 'observed': [1830, 1900, 2489], 'SK-N-SH,': [1832], 'neuroblastoma': [1834], 'line.': [1836], 'This': [1837, 1859, 1905, 2094, 3691], 'most': [1840], 'monomer.': [1845, 2188], 'detected': [1854, 2167, 2337, 2345, 2629, 2813, 2928, 3136], 'lines.': [1858, 1904, 1973], 'rapid': [1864, 1871], 'turnover': [1865], '(see': [1878, 2587], 'below).': [1879], 'addition': [1881], 'band,': [1885, 2951], 'prominent': [1887], '(p90)': [1890], 'series': [1893], 'all': [1902, 2892], 'unexpected': [1908], 'because': [1909, 2920], 'possessed': [1911], 'invariant': [1913, 2202, 2394], 'would': [1921], 'allow': [1922, 3154, 3421], '(3Hershko': [1936, 2109, 2253, 2900], 'Scholar).Figure': [1963], '2Western': [1964], 'human': [1971, 3464], 'Total': [1974], 'lysates': [1976, 2042], 'analyzed': [1978], 'MBP-sentrin.View': [1997], 'Large': [1998], 'Image': [1999], 'Figure': [2000], 'ViewerDownload': [2001], 'Hi-res': [2002], 'image': [2003], 'Download': [2004], '(PPT)': [2005], 'biochemistry': [2009], 'detail,': [2015], 'utilized.': [2026, 2796], 'Briefly,': [2027], 'mutant': [2030, 2834, 2917, 2946, 3345], 'liposome-mediated': [2037], 'transfection,': [2038], 'prepared': [2044, 2078], 'transfection': [2048, 2160, 2180], 'antiserum.': [2059], '(HA-Ubiquitin)': [2062], 'control.': [2067], 'Fig.3': [2071], 'A,': [2072, 2625], 'expressing': [2082, 2140], 'HA-Ubiquitin': [2083, 2606, 2626], 'ladder': [2086], 'multimers,': [2090], 'ubiquitin-conjugated': [2092], 'proteins.': [2093, 2428, 2555, 3372], 'pattern': [2095, 2371], 'seen': [2100, 2693, 2942], 'contrast,': [2138], 'HA-Sentrin': [2139], 'p90,': [2149, 2373], 'higher': [2151], 'conjugates.': [2155], 'yields': [2162], 'results': [2163, 2506, 2530, 2856, 2939], '2.': [2174], 'addition,': [2176], 'allowed': [2182], 'clear': [2183], 'unconjugated': [2187], 'four': [2195, 2298, 2363], '(His-Ser-Thr-Val)': [2198], 'follows': [2200], 'conjugating': [2247], 'enzymes': [2248], 'eventually': [2250], 'order': [2282], 'serve': [2286], 'have': [2301, 2760, 3098, 3316, 3449, 3469], 'removed.': [2304], 'address': [2306], 'question': [2308], 'construct': [2314], 'HA-tag': [2317, 2352, 2819], 'attached': [2318, 3069], 'made.': [2324], 'Sen-GGHSTV-HA': [2326], 'mAb': [2340], 'still': [2342], 'antiserum,': [2348], 'suggesting': [2349], 'had': [2353, 2502], 'cleaved': [2355], '(Fig.': [2356, 2386, 2490, 2781, 2935], 'B,lane': [2358], '4).': [2359], 'removed': [2367], '(HA-Sen-GG),': [2368], '(monomer,': [2372], 'bands)': [2378, 2734], 'HA-Sen-GGHSTV': [2384], 'transfectant': [2385], 'B,': [2388, 2492, 2515, 2667, 2841], '5).': [2390], 'Removal': [2391], 'Gly97': [2395, 2419, 2864], '(HA-Sen-G)': [2397], 'completely': [2398, 3131], 'abolished': [2399], '(data': [2410], 'shown).': [2412], 'essential': [2421, 3273], 'yeast,': [2431], 'mutation': [2432, 2477, 2536], 'Gly-Ala': [2440, 2535], 'impair': [2445], 'hydrolase': [2446, 3374], 'activity': [2447, 3375], 'cause': [2449], 'irreversible': [2450], '(12Hodgins': [2457], 'R.R.W.': [2458], 'Ellison': [2459, 2461], 'K.S.': [2460], 'M.J.': [2462, 3016, 3287, 3398, 3710], '268:': [2467], '8807-8812Abstract': [2468], 'made': [2479], '(HA-Sen-GAHSTV),': [2482], '7).': [2494], 'significantly': [2503], 'decreased.': [2504], 'Similar': [2505, 2938], 'obtained': [2508], 'second': [2511], 'construct,': [2512], 'HA-Sen-GA(Fig.': [2513], '6).': [2517], 'theHA-Sen-GA': [2520], 'lysate,': [2521], '∼100-kDa': [2523], '(p100)': [2525], 'These': [2529, 2567, 3577, 3726], 'suggest': [2531, 2569], 'molecule': [2540], 'profound': [2543], 'processing': [2548, 2786, 2879, 2890], 'fact,': [2557], 'consistently': [2565], 'observations': [2568, 3727], 'key': [2574, 2978], 'intermediate': [2575, 2979], 'discussion).': [2588], 'subcellular': [2590], 'localization': [2591], 'determined': [2598], 'next.': [2599], 'orHA-Sentrin': [2607], 'cDNA-containing': [2608], 'plasmids': [2609], 'previously,': [2612], 'fixed,': [2613], 'permeabilized,': [2614], 'stained': [2616], 'mAb.': [2619, 2661], 'cytosol': [2633, 3243, 3427], 'contrast,HA-Sentrin': [2638], 'mostly': [2640, 2682, 2694], 'restricted': [2641], 'nucleus.HA-Sentrin': [2644], 'fractionated': [2650], 'cytosolic': [2652], '(S100)': [2653], 'fraction': [2656], 'immunoblotted': [2658], 'highly': [2674], 'enriched': [2675], 'associated': [2683, 3376, 3701], 'monomers': [2691], 'Moreover,': [2720, 2854], 'cellular': [2726], '(p90': [2728], 'appear': [2743], 'localize': [2745], 'predominately': [2746], 'Using': [2750], 'expressed': [2766], 'low': [2768], 'levels': [2769], 'detectable': [2776], 'types': [2780], '2).': [2782], 'Plasmids': [2797], 'cDNA': [2801, 3455], 'inserts': [2802], 'tagged': [2810], 'placed': [2821], 'wild': [2830], 'processed': [2849], 'our': [2855], 'requirement': [2860], 'natural': [2893], 'fusion': [2895], 'hydrolases': [2899], 'HA-Sen-GAHSTV': [2916, 3344], 'informative': [2919], 'B).': [2937], 'HA-Sen-GA': [2945], 'except': [2947], 'p100,': [2952], 'p90.': [2970], 'words,': [2973], 'precise': [2990], 'awaits': [2992], 'detail': [2995], 'examination': [2996], 'enzymology': [2999], 'While': [3006], 'manuscript': [3008], 'being': [3010], 'prepared,': [3011], 'Matunis': [3012], 'et': [3013, 3034, 3460, 3532], 'al.': [3014, 3035, 3533], '(13Matunis': [3015, 3286, 3397, 3709], 'Coutavas': [3017, 3288, 3399, 3711], 'Blobel': [3019, 3290, 3401, 3713], 'G.': [3020, 3291, 3402, 3714], '135:': [3025, 3296, 3407, 3719], '1457-1470Crossref': [3026, 3297, 3408, 3720], '(957)': [3029, 3300, 3411, 3723], 'Scholar)': [3031, 3059, 3196], 'Mahajan': [3033], '(14Mahajan': [3036], 'Delphin': [3038], 'Guan': [3040], 'Gerace': [3042], 'Melchior': [3044], 'F.': [3045, 3221], '1997;': [3047], '88:': [3048], '97-107Abstract': [3049], '(1006)': [3057], '(GMP1/SUMO-1)': [3066], 'covalently': [3068], 'Ran-GTP,': [3071], '70-kDa': [3073], 'Ras-like': [3074], 'GTPase': [3075], 'bidirectional': [3079], 'transport': [3080, 3321], 'ribonucleoproteins': [3084], 'across': [3085], 'pore': [3088, 3284, 3380, 3391, 3418], 'GMP1/SUMO-1': [3091], 'p70': [3104], '(unmodified': [3105], 'RanGAP1)': [3106, 3111, 3355], '(presumably': [3109], 'transiently': [3115], 'RanGAP1': [3120, 3161, 3238, 3268, 3306, 3387, 3422, 3699], 'plasmid.': [3121], '2T.': [3122], 'Kamitani,': [3123], 'unpublished': [3124], 'results.': [3125], 'At': [3126], 'present,': [3127], 'cannot': [3129], 'certain': [3132], 'communication': [3139], '(or': [3144], 'GMP1-modified)': [3145], 'RanGAP1.': [3146], 'similarity': [3149], 'compelling': [3151], 'enough': [3152], 'us': [3155], 'make': [3157], 'temporary': [3159], 'assignment.': [3160], 'homologue': [3164, 3641], 'murine': [3167], 'Fug1': [3168], '(15DeGregori': [3169], 'Russ': [3171], 'von': [3173], 'Melchner': [3174], 'Rayburn': [3176], 'Priyaranjan': [3178], 'Jenkins': [3180], 'N.A.': [3181], 'Copeland': [3182], 'N.G.': [3183], 'Ruley': [3184], 'H.E.': [3185], 'Genes': [3186], '&': [3187], 'Dev.': [3188], '8:': [3190], '265-276Crossref': [3191], '(89)': [3194], 'Saccharomyces': [3198], 'cerevisiae': [3199], 'Schizosaccharomyces': [3201], 'pombe': [3202], 'Rna1p': [3203], '(16Atkinson': [3204], 'N.S.': [3205], 'Dunst': [3206, 3253], 'R.W.': [3207, 3254], 'Hopper': [3208], 'A.K.': [3209, 3250], '1985;': [3213], '5:': [3214], '907-915Crossref': [3215], '(30)': [3218], 'Scholar,17Melchior': [3220], 'Weber': [3222], 'Gerke': [3224], '1993;': [3229, 3668], '4:': [3230], '569-581Crossref': [3231], '(78)': [3234], 'Unmodified': [3237], 'excluded': [3245], '(18Hopper': [3249], 'Traglia': [3251], '1990;': [3258], '111:': [3259], '309-321Crossref': [3260], '(167)': [3263], 'Modification': [3266], 'GMP1': [3270], '(sentrin)': [3271], 'translocation': [3276, 3313], 'cytoplasmic': [3279], 'fiber': [3280], 'step': [3310], 'should': [3315], 'important': [3317, 3590], 'implications': [3318], 'nucleocytoplasmic': [3320], '(19Gorlich': [3322], 'Mattaj': [3324], 'I.W.': [3325], 'Science.': [3326], '1513-1544Crossref': [3329], '(1066)': [3332], 'Absence': [3335], 'entirely': [3347], 'consistent': [3348, 3693], 'hypothesis': [3351], '(sentrinized': [3354], 'plays': [3356], 'delivery': [3362], 'A': [3373], 'releases': [3383], 'Desentrinization': [3414], 'might': [3420], 'return': [3424], 'enter': [3431], 'Further': [3434], 'work': [3435], 'confirm': [3439], 'hypothesis.': [3441], 'past': [3444], 'year,': [3445], 'groups': [3448], 'cloning': [3453], 'Shen': [3459], 'al.,': [3461], 'RAD51': [3465], 'bait,': [3468], 'cloned': [3470], 'UBL1': [3474, 3494], '(20Shen': [3475, 3512], 'Z.': [3476, 3513], 'Pardington-Purtymun': [3477, 3514], 'P.E.': [3478, 3515], 'Comeaux': [3479, 3516], 'J.C.': [3480, 3517], 'Moyzis': [3481, 3518], 'R.K.': [3482, 3519], 'Chen': [3483, 3520], 'Genomics.': [3485, 3522], '36:': [3487, 3524], '271-279Crossref': [3488, 3525], '(183)': [3491, 3528], 'RAD52,': [3498, 3600, 3615], 'part': [3501], 'mediates': [3506], 'repair': [3507], 'double-strand': [3510], 'breaks': [3511], 'Boddy': [3531], 'PML,': [3535, 3602], 'critically': [3538], 'involved': [3539], 'pathogenesis': [3542], 'acute': [3544], 'promyelocytic': [3545], 'leukemia,': [3546], 'identified': [3554], 'PML-interacting': [3557], 'clone,': [3558], 'PIC1': [3559], '(21Boddy': [3560], 'M.N.': [3561], 'Howe': [3562], 'Etkin': [3564], 'L.D.': [3565], 'Solomon': [3566], 'E,': [3567], 'Freemont': [3569], 'P.S.': [3570], 'Oncogene.': [3571], ':': [3573], '971-982PubMed': [3574], 'reports': [3578], 'provided': [3579], 'tantalizing': [3580], 'clues': [3581], 'regarding': [3582], 'potential': [3584], 'interaction': [3585], 'biologically': [3589], 'such': [3592], 'Fas,': [3595], 'TNF': [3596], '1,': [3598], 'RAD51,': [3599, 3614], 'possible': [3612], 'PML': [3617], 'themselves': [3620], 'rather': [3623], 'bind': [3624], 'noncovalent': [3630], 'interaction.': [3631], 'interest': [3635], 'note': [3637], 'smt3,': [3644], 'capable': [3646], 'correcting': [3648], 'conditional': [3650], 'lethalmif2': [3651], 'mutation,': [3652], 'increased': [3655], 'mitotic': [3656, 3704], 'chromosome': [3657], 'instability': [3658], '(22Brown': [3659], 'M.T.': [3660], 'Goetsch': [3661], 'Hartwell': [3663], 'L.H.': [3664], '123:': [3669], '387-403Crossref': [3670], '(96)': [3673], '23Meluh': [3676], 'P.B.': [3677], 'Koshland': [3678], '6:': [3684], '793-807Crossref': [3685], '(353)': [3688], 'finding': [3696], 'spindle': [3705], 'apparatus': [3706], 'during': [3707], 'mitosis': [3708], 'further': [3728], 'underlie': [3729], 'importance': [3731], 'thank': [3736], 'Limin': [3738], 'Gong,': [3739], 'Katsumi': [3740], 'Kito,': [3741], 'Pamela': [3743], 'Beck': [3744], 'review': [3747], 'manuscript.': [3750]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2080101736', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-08T22:36:10.666914', 'created_date': '2016-06-24'}