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61, 73, 80, 94, 100, 119, 130, 135, 154, 167, 174, 189, 206, 213, 220, 226, 243, 252, 260, 266], 'pre-mRNA': [14], 'processing': [15, 21, 219, 242], 'factors,': [16], 'post-transcriptional': [20, 218], 'pre-mRNAs.': [23], 'Oculopharyngeal': [24], 'muscular': [25], 'dystrophy': [26], '(OPMD)': [27], 'is': [28, 57, 193], 'caused': [29], 'by': [30], 'a': [31, 235], 'small': [32], 'expansion': [33], 'polyalanine': [36], 'tract': [37], 'poly(A)-binding': [40], 'protein': [41], '1': [43], '(PABPN1).': [44], 'Aggregation': [45], 'expanded': [47, 147], 'PABPN1': [48, 111, 120, 155, 178, 207], 'into': [49], 'intranuclear': [50], 'inclusions': [51], '(INIs)': [52], 'skeletal': [54], 'muscle': [55, 71, 114, 128, 231], 'fibers': [56, 72, 129, 232], 'pathological': [59], 'hallmark': [60], 'OPMD.': [62, 253], 'In': [63], 'this': [64], 'study': [65], 'what': [66], 'we': [67], 'have': [68], 'analyzed': [69], 'OPMD': [74, 131], 'patients': [75], 'primary': [78], 'cultures': [79], 'human': [81, 139], 'myoblasts': [82, 140, 199], 'relationships': [85], 'between': [86], 'INIs,': [90], 'contribution': [93], 'former': [96], 'to': [97, 248], 'biogenesis': [99, 204], 'latter.': [102], 'While': [103], 'concentrate': [106], 'snRNP': [107], 'splicing': [108], 'factors': [109], 'control': [113], 'fibers,': [115], 'they': [116], 'depleted': [118], 'appear': [122], 'closely': [123], 'associated': [124], 'with': [125], 'INIs': [126, 162, 175], 'patients.': [132], 'The': [133], 'induction': [134], 'INI': [136], 'formation': [137], 'expressing': [141], 'either': [142], 'wild': [143], 'type': [144], 'GFP-PABPN1': [145], 'or': [146], 'GFP-PABPN1-17ala': [148], 'demonstrates': [149], 'that': [150], 'initial': [152], 'aggregation': [153], 'proteins': [156, 179], 'their': [158], 'subsequent': [159], 'growth': [160], 'occurs': [163], 'at': [164], 'edges': [166], 'speckles.': [170], 'Moreover,': [171], 'growing': [173], 'gradually': [176], 'depletes': [177], 'poly(A)': [181], 'RNA': [182], 'from': [183], 'speckles,': [185], 'although': [186], 'existence': [188], 'these': [190, 227], 'preserved.': [194], 'Time-lapse': [195], 'experiments': [196], 'cultured': [198], 'confirm': [200], 'as': [203, 263], 'sites': [205], 'inclusions.': [208], 'Given': [209], 'functional': [211], 'importance': [212, 259], 'pre-mRNAs,': [221], 'INI-dependent': [223], 'molecular': [224, 250], 'reorganization': [225], 'may': [233], 'cause': [234], 'severe': [236], 'dysfunction': [237], 'trafficking': [240], 'polyadenylated': [244], 'mRNAs,': [245], 'thereby': [246], 'contributing': [247], 'pathophysiology': [251], 'Our': [254], 'results': [255], 'emphasize': [256], 'potential': [258], 'targets': [265], 'neuromuscular': [267], 'disorders.': [268]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2079996603', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 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