Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2079867419', 'doi': 'https://doi.org/10.1016/j.bbrc.2003.11.008', 'title': 'Cu/Zn superoxide dismutase can form pore-like structures', 'display_name': 'Cu/Zn superoxide dismutase can form pore-like structures', 'publication_year': 2003, 'publication_date': '2003-11-21', 'ids': {'openalex': 'https://openalex.org/W2079867419', 'doi': 'https://doi.org/10.1016/j.bbrc.2003.11.008', 'mag': '2079867419', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14651952'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2003.11.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009272259', 'display_name': 'Jinhyuk Fred Chung', 'orcid': 'https://orcid.org/0000-0001-8766-7446'}, 'institutions': [{'id': 'https://openalex.org/I165799507', 'display_name': 'Rensselaer Polytechnic Institute', 'ror': 'https://ror.org/01rtyzb94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165799507']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jinhyuk Chung', 'raw_affiliation_strings': ['Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.'], 'affiliations': [{'raw_affiliation_string': 'Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.', 'institution_ids': ['https://openalex.org/I165799507']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074865383', 'display_name': 'Hoichang Yang', 'orcid': 'https://orcid.org/0000-0003-0585-8527'}, 'institutions': [{'id': 'https://openalex.org/I165799507', 'display_name': 'Rensselaer Polytechnic Institute', 'ror': 'https://ror.org/01rtyzb94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165799507']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hoichang Yang', 'raw_affiliation_strings': ['Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.'], 'affiliations': [{'raw_affiliation_string': 'Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.', 'institution_ids': ['https://openalex.org/I165799507']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063771912', 'display_name': 'Mitchel D. de Beus', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165799507', 'display_name': 'Rensselaer Polytechnic Institute', 'ror': 'https://ror.org/01rtyzb94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165799507']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mitchel D de Beus', 'raw_affiliation_strings': ['Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.'], 'affiliations': [{'raw_affiliation_string': 'Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.', 'institution_ids': ['https://openalex.org/I165799507']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069800673', 'display_name': 'Chang Y. Ryu', 'orcid': 'https://orcid.org/0000-0002-8013-0328'}, 'institutions': [{'id': 'https://openalex.org/I165799507', 'display_name': 'Rensselaer Polytechnic Institute', 'ror': 'https://ror.org/01rtyzb94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165799507']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chang Y Ryu', 'raw_affiliation_strings': ['Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.'], 'affiliations': [{'raw_affiliation_string': 'Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.', 'institution_ids': ['https://openalex.org/I165799507']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050241476', 'display_name': 'Kilwon Cho', 'orcid': 'https://orcid.org/0000-0003-0321-3629'}, 'institutions': [{'id': 'https://openalex.org/I123900574', 'display_name': 'Pohang University of Science and Technology', 'ror': 'https://ror.org/04xysgw12', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I123900574']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kilwon Cho', 'raw_affiliation_strings': ['Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Kyoungbuk 790-784, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Kyoungbuk 790-784, Republic of Korea', 'institution_ids': ['https://openalex.org/I123900574']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036860380', 'display_name': 'Wilfredo Colón', 'orcid': 'https://orcid.org/0000-0001-6599-0218'}, 'institutions': [{'id': 'https://openalex.org/I165799507', 'display_name': 'Rensselaer Polytechnic Institute', 'ror': 'https://ror.org/01rtyzb94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165799507']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wilfredo Colón', 'raw_affiliation_strings': ['Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.'], 'affiliations': [{'raw_affiliation_string': 'Rensselaer Polytechnic Institute, Department of Chemistry, 110 8th street, Troy, NY 12180, USA.', 'institution_ids': ['https://openalex.org/I165799507']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.907, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.79713, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '312', 'issue': '4', 'first_page': '873', 'last_page': '876'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10855', 'display_name': 'Amyotrophic Lateral Sclerosis and Frontotemporal Dementia', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10855', 'display_name': 'Amyotrophic Lateral Sclerosis and Frontotemporal Dementia', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Pathophysiology of Parkinson's Disease", 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13481', 'display_name': 'Neurodegeneration with Brain Iron Accumulation', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dismutase', 'display_name': 'Dismutase', 'score': 0.65089214}, {'id': 'https://openalex.org/keywords/neurodegeneration', 'display_name': 'Neurodegeneration', 'score': 0.508978}], 'concepts': [{'id': 'https://openalex.org/C2780596555', 'wikidata': 'https://www.wikidata.org/wiki/Q206901', 'display_name': 'Amyotrophic lateral sclerosis', 'level': 3, 'score': 0.91024065}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.8759253}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.75434744}, {'id': 'https://openalex.org/C2777615887', 'wikidata': 'https://www.wikidata.org/wiki/Q15328137', 'display_name': 'SOD1', 'level': 4, 'score': 0.7045394}, {'id': 'https://openalex.org/C2778248901', 'wikidata': 'https://www.wikidata.org/wiki/Q5282371', 'display_name': 'Dismutase', 'level': 4, 'score': 0.65089214}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.52611476}, {'id': 'https://openalex.org/C136238340', 'wikidata': 'https://www.wikidata.org/wiki/Q7251455', 'display_name': 'Protein aggregation', 'level': 2, 'score': 0.512786}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.47582176}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.47209305}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.45045665}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.44713587}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.44259086}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.39086747}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36749303}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.3302193}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.296632}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.2909315}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.09670225}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.07974395}], 'mesh': [{'descriptor_ui': 'D003300', 'descriptor_name': 'Copper', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014867', 'descriptor_name': 'Water', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D003300', 'descriptor_name': 'Copper', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004795', 'descriptor_name': 'Enzyme Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018625', 'descriptor_name': 'Microscopy, Atomic Force', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016062', 'descriptor_name': 'Porosity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014867', 'descriptor_name': 'Water', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2003.11.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14651952', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1991241547', 'https://openalex.org/W2034120336', 'https://openalex.org/W2034370881', 'https://openalex.org/W2038209272', 'https://openalex.org/W2038339021', 'https://openalex.org/W2038941603', 'https://openalex.org/W2053040219', 'https://openalex.org/W2073810813', 'https://openalex.org/W2073864172', 'https://openalex.org/W2093861673', 'https://openalex.org/W2096386031', 'https://openalex.org/W2096678032', 'https://openalex.org/W2097066519', 'https://openalex.org/W2097228496', 'https://openalex.org/W2097965815', 'https://openalex.org/W2106392233', 'https://openalex.org/W2110284480', 'https://openalex.org/W2122176030', 'https://openalex.org/W2125606478', 'https://openalex.org/W2140595389', 'https://openalex.org/W2147220169'], 'related_works': ['https://openalex.org/W4300747581', 'https://openalex.org/W3151746898', 'https://openalex.org/W2586253893', 'https://openalex.org/W2357993352', 'https://openalex.org/W2160523206', 'https://openalex.org/W2070740797', 'https://openalex.org/W2057689545', 'https://openalex.org/W2047018448', 'https://openalex.org/W2029435936', 'https://openalex.org/W1980777356'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 74, 93, 125], 'Cu/Zn': [2], 'superoxide': [3], 'dismutase': [4], '(SOD)': [5], 'are': [6], 'associated': [7], 'with': [8], 'familial': [9], 'amyotrophic': [10], 'lateral': [11], 'sclerosis': [12], '(FALS),': [13], 'a': [14, 50, 122], 'neurodegenerative': [15, 99], 'disease': [16], 'that': [17, 65, 106], 'is': [18, 48], 'characterized': [19], 'by': [20, 40, 82], 'the': [21, 28, 33, 36, 38, 42, 66, 94, 104, 107], 'selective': [22], 'death': [23], 'of': [24, 69, 97, 110], 'motor': [25], 'neurons.': [26], 'Despite': [27], 'genetic': [29], 'association': [30], 'made': [31], 'between': [32], 'protein': [34], 'and': [35, 55, 61], 'disease,': [37], 'mechanism': [39, 96], 'which': [41], 'mutant': [43], 'SOD': [44, 54, 71, 113], 'proteins': [45], 'become': [46], 'toxic': [47, 87, 116], 'still': [49], 'mystery.': [51], 'Using': [52], 'wild-type': [53], 'three': [56], 'pathogenic': [57, 95], 'mutants': [58, 114], '(A4V,': [59], 'G37R,': [60], 'G85R),': [62], 'we': [63], 'show': [64], 'copper-induced': [67], 'oxidation': [68], 'metal-depleted': [70], 'causes': [72], 'its': [73], 'vitro': [75], 'aggregation': [76], 'into': [77, 115], 'pore-like': [78], 'structures,': [79], 'as': [80], 'determined': [81], 'atomic': [83], 'force': [84], 'microscopy.': [85], 'Because': [86], 'pores': [88, 119], 'have': [89, 121], 'been': [90], 'recently': [91], 'implicated': [92], 'other': [98], 'diseases,': [100], 'these': [101], 'results': [102], 'raise': [103], 'possibility': [105], 'aberrant': [108], 'self-assembly': [109], 'oxidatively': [111], 'damaged': [112], 'oligomers': [117], 'or': [118], 'may': [120], 'pathological': [123], 'role': [124], 'FALS.': [126]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2079867419', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-17T16:02:11.037835', 'created_date': '2016-06-24'}