Regulation of Phospholipase D in HL60 Cells

Name: Work Video:
Duration: 3 min 30 s
Abdur Rehman Siddiqi; Jennie L. Smith; Annette H. Ross; Rong-Guo Qiu; Marc Symons; John H. Exton
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1580, 1587, 1591, 1685, 1750, 1758, 1764, 1856, 2089, 2093, 2138, 2165, 2173, 2218, 2224, 2243, 2293, 2314, 2424, 2488, 2491, 2498, 2562, 2565, 2646, 2825, 2860, 2943, 2954, 3003, 3044, 3064, 3129, 3139, 3151, 3197, 3219, 3235, 3254, 3275, 3307, 3313, 3323, 3330, 3357, 3366, 3401, 3432, 3450, 3457, 3463, 3479, 3492, 3510, 3521, 3549, 3682, 3728, 3735, 3744, 3776, 3779, 3818, 3832, 3853, 3907, 3948, 3978, 4000, 4013, 4024, 4036, 4039, 4073, 4080, 4090, 4112, 4160, 4165, 4168, 4189, 4197, 4209, 4217, 4238, 4254, 4271, 4297, 4358, 4370, 4378, 4387, 4395, 4416, 4431, 4443, 4476, 4500, 4578, 4591, 4610, 4613, 4622, 4629, 4760, 4789, 4803, 4820, 4834, 4845, 4851, 4868, 4877, 4882, 5009, 5017, 5041, 5092, 5133, 5179, 5223, 5226, 5269, 5286, 5317, 5325, 5334, 5358, 5369, 5377, 5407, 5414, 5427, 5443, 5465, 5470, 5489, 5505, 5508, 5514, 5544, 5576, 5582, 5671, 5712, 5736, 5762, 5779, 5785, 5864, 5868, 5897, 5960, 5963, 5965, 5987, 6004, 6009], 'HL60': [19, 270, 291, 543, 1174, 1444, 1471, 1552, 1831, 1914, 2318, 2767, 2861, 3100, 3120, 3544, 3611, 3766, 3958, 3973, 4099, 4200, 4278, 4366, 4427, 4761], 'cells.': [20, 271, 292, 544], 'GTPγS-stimulated': [21, 293, 3236, 3276, 3314, 3382, 3770, 3805], 'PLD': [22, 53, 130, 197, 211, 235, 246, 267, 294, 325, 403, 470, 484, 508, 519, 540, 694, 923, 1047, 1176, 1416, 1441, 1468, 1478, 1494, 2151, 2211, 2308, 2323, 2349, 2851, 2944, 3077, 3118, 3131, 3177, 3189, 3198, 3237, 3277, 3291, 3315, 3383, 3394, 3414, 3434, 3581, 3608, 3692, 3745, 3771, 3807, 3846, 4002, 4019, 4116, 4179, 4195, 4289, 4364, 4444, 4452, 4504, 4561, 4592, 4618, 4763, 4791, 4822, 4846, 4856, 4869, 4884, 4892, 4911, 4945, 5012, 5020, 5043, 5066, 5086, 5136, 5215, 5231, 5257, 5287, 5318, 5509, 5539, 5561, 5584, 5786, 5898, 5966], 'the': [27, 36, 81, 97, 110, 133, 151, 176, 189, 202, 209, 213, 218, 231, 250, 260, 299, 308, 353, 369, 382, 406, 424, 449, 462, 475, 482, 486, 491, 504, 523, 533, 591, 684, 928, 933, 1149, 1190, 1327, 1331, 1349, 1363, 1404, 1412, 1475, 1492, 1501, 1510, 1605, 1621, 1661, 1790, 2046, 2128, 2171, 2201, 2214, 2241, 2284, 2411, 2429, 2477, 2481, 2486, 2504, 2551, 2555, 2560, 2569, 2592, 2756, 2823, 2949, 2952, 2970, 3001, 3005, 3042, 3062, 3115, 3136, 3140, 3149, 3174, 3184, 3212, 3217, 3233, 3251, 3255, 3258, 3282, 3301, 3305, 3331, 3355, 3363, 3398, 3402, 3408, 3413, 3442, 3451, 3461, 3477, 3480, 3493, 3502, 3508, 3547, 3584, 3662, 3670, 3694, 3714, 3733, 3742, 3816, 3830, 3845, 3908, 3930, 3941, 3976, 3998, 4018, 4022, 4034, 4040, 4071, 4078, 4088, 4110, 4194, 4215, 4236, 4293, 4304, 4375, 4388, 4393, 4432, 4441, 4451, 4460, 4477, 4498, 4510, 4548, 4553, 4560, 4564, 4576, 4589, 4605, 4608, 4611, 4620, 4627, 4787, 4798, 4801, 4818, 4843, 4848, 4855, 4865, 4875, 4880, 4891, 4900, 4925, 5003, 5006, 5010, 5018, 5039, 5046, 5055, 5081, 5084, 5093, 5134, 5169, 5177, 5200, 5218, 5224, 5234, 5289, 5296, 5306, 5315, 5326, 5331, 5345, 5356, 5367, 5385, 5391, 5400, 5405, 5412, 5420, 5423, 5441, 5463, 5468, 5487, 5503, 5511, 5541, 5577, 5591, 5611, 5669, 5680, 5683, 5695, 5710, 5724, 5732, 5740, 5757, 5760, 5767, 5777, 5783, 5865, 5895, 5918, 5934, 5948, 5961, 5988, 5992], 'when': [29, 45, 301, 317, 1864, 2958, 3669, 3827, 4507, 4772, 4779, 4890, 5298, 5766], 'exogenous': [30, 302, 2959, 3103, 3498, 3675, 3835, 4513, 4614, 4780, 4835, 4928, 5598, 5721], 'labeled': [31, 303, 1871], 'phosphatidylcholine': [32, 304, 594, 996, 1026], 'used': [34, 306, 550, 571, 2042, 2159, 3446, 4783], 'presence': [37, 134, 177, 214, 232, 309, 407, 450, 487, 505, 1191, 1476, 2215, 2311, 3218, 3306, 3462, 3548, 3817, 3947, 3977, 4089, 4111, 4216, 4237, 4294, 4394, 4621, 4788, 4819, 4844, 5225, 5426, 5442, 5488, 5504], 'phosphatidylethanolamine': [39, 311, 1518], 'phosphatidylinositol': [41, 313, 999, 1029], '4,5-bisphosphate,': [42, 314], 'but': [43, 62, 180, 315, 334, 453, 2956, 3105, 3339, 3416, 3470, 3982, 4984, 5071, 5292, 5350, 5565], 'not': [44, 181, 316, 454, 3011, 3111, 3337, 3483, 3513, 3598, 3938, 3944, 3969, 3983, 3990, 4045, 4184, 5072, 5242, 5343, 5452, 5485, 5535, 5566, 5754], '[3H]myristic': [46, 318, 1873, 3051, 4492, 4773], 'acid-labeled': [47, 319, 2317, 4493, 4774], 'endogenous': [48, 190, 251, 320, 463, 524, 3297, 3424, 3616, 3811, 4921, 5397, 5600, 5768], 'substrate': [49, 321, 2964, 3617, 3812, 4514, 4785, 4836, 5769], 'used.': [51, 323, 4777], 'Cytosolic': [52, 324], 'co-chromatographed': [54, 326], 'with': [55, 327, 1055, 1598, 1789, 1872, 2001, 2109, 2133, 2200, 2234, 2265, 2289, 2614, 2674, 2730, 2746, 2771, 2966, 3204, 3387, 3421, 3497, 3674, 3701, 3855, 4006, 4124, 4162, 4206, 4374, 4438, 4491, 4512, 4573, 4604, 4684, 4871, 5191, 5205, 5595], 'small': [56, 191, 328, 464, 990, 1020, 1332, 2841], 'GTP-binding': [57, 192, 329, 465, 555, 576, 988, 991, 1018, 1021], 'proteins': [58, 83, 156, 330, 355, 429, 1622, 1662, 2130, 2702, 2843, 3865, 4082, 4192, 5240, 5251, 5364, 5416], 'on': [59, 331, 1348, 1625, 2097, 2656, 2686, 3099, 3369, 4059, 4178, 4193, 4221, 4362, 4399, 4924, 5002, 5031, 5399], 'anion-exchange': [60, 332], 'columns,': [61, 333], 'subsequent': [63, 335], 'chromatography': [64, 336, 2658], 'separated': [65, 337, 3295, 4854, 4898, 4913], 'these.': [66, 338], 'Reconstitution': [67, 339], 'studies': [68, 340, 4490], 'demonstrated': [69, 341, 1438], 'ADP': [70, 342, 1003, 1033, 1336, 1360, 1679], 'ribosylation': [71, 343, 561, 582, 1004, 1034, 1337, 1361, 1680], 'factor': [72, 344, 1005, 1035, 1195, 1329, 1338, 1681], '(ARF)': [73, 345], 'as': [74, 346, 1354, 1481, 1483, 1632, 1879, 2325, 2508, 2573, 2963, 3441, 3773, 4134, 4246, 4344, 4408, 4484, 4550, 4552, 4784], 'a': [75, 225, 347, 498, 610, 687, 941, 1193, 1239, 1355, 1407, 1450, 1458, 1599, 1626, 1853, 1994, 2098, 2134, 2182, 2189, 2222, 2256, 2290, 2418, 2720, 3194, 3268, 3311, 3320, 3350, 3370, 3665, 3698, 3729, 3774, 4056, 4106, 4128, 4163, 4175, 4385, 5446, 5686, 5750], 'regulator': [76, 252, 348, 525], 'cytosolic': [78, 90, 350, 362, 1194, 1328, 3117, 3221, 3358, 3452, 4473, 4478, 4883, 4993, 5019, 5032, 5056, 5065, 5560], 'PLD,': [79, 351, 3257, 3359, 5480, 5559], 'whereas': [80, 109, 352, 381, 2045, 3932, 4062, 5015, 5083], 'Rho': [82, 155, 354, 428, 1413, 1577, 3425, 3738, 3864, 4081, 4191, 4272, 5094, 5237, 5249, 5392, 5415, 5518, 5790, 5956], 'RhoA': [84, 160, 187, 221, 356, 433, 460, 494, 3205, 3925, 4026, 4049, 4093, 4102, 4170, 4359, 4380, 4389, 4933, 5073, 5276, 5381, 5437, 5466, 5474, 5483, 5496, 5690, 5869], 'CDC42Hs': [86, 358, 1820], 'were': [87, 163, 359, 436, 1524, 1536, 1548, 1554, 1563, 1596, 1623, 1663, 1673, 1719, 1747, 1770, 1821, 1833, 1862, 1870, 1877, 1904, 1919, 1953, 1991, 2014, 2028, 2079, 2131, 2148, 2156, 2208, 2305, 2320, 2426, 2466, 2483, 2506, 2557, 2571, 2595, 2612, 2654, 2671, 2703, 2727, 2753, 2769, 2794, 2804, 2808, 2817, 2833, 3097, 3155, 3171, 3239, 3672, 3937, 3962, 3995, 4052, 4096, 4204, 4228, 4286, 4310, 4321, 4328, 4372, 4776, 4863, 4936, 4995, 5279, 5717], 'ineffective.': [88, 360, 4937], 'The': [89, 139, 242, 257, 361, 412, 515, 530, 1464, 1572, 2105, 2249, 2260, 2610, 2725, 2827, 3037, 3229, 3328, 3392, 3429, 3454, 3485, 3515, 3921, 3946, 3992, 4158, 4226, 4404, 4832, 5064, 5580, 5734, 5907], 'enzyme': [91, 112, 363, 384, 4511, 5688, 5920], 'showed': [92, 175, 224, 364, 448, 497, 3504, 3697, 3923, 3975, 4174, 4998, 5129], 'very': [93, 365, 3008, 4999, 5028], 'little': [94, 366], 'absence': [98, 136, 203, 370, 409, 476, 1502, 2217, 2313, 2824, 2953, 3002, 3063, 3478, 3509, 3831, 4035, 4296, 4577, 4802, 5178, 5424, 5761], 'GTPγS': [100, 126, 372, 399, 1188, 1499, 1535, 2941, 3464, 3511, 3516, 4113, 4218, 4298, 4396, 4574, 4623, 4765, 4794, 5131, 5201, 5284, 5428, 5672, 5751], '2': [105, 377, 2455, 2744, 3683, 3702, 3987], 'm': [106, 378, 1926, 1932, 1936, 1940, 1944, 1948, 1959, 1965, 1969, 1973, 2056, 2062, 2066, 2070, 2075, 2113, 2119, 2124, 2247, 2269, 2275, 2280, 2297, 2433, 2439, 2443, 2447, 2451, 2456, 2777, 2783, 3684, 3703], 'M': [107, 379, 1927, 1933, 1937, 1941, 1945, 1949, 1960, 1966, 1970, 1974, 2057, 2063, 2067, 2071, 2076, 2114, 2120, 2125, 2270, 2276, 2281, 2434, 2440, 2444, 2448, 2452, 2457, 2778, 2784, 3685, 3704, 3710], 'Ca2+,': [108, 380, 3712], 'membrane': [111, 129, 210, 383, 402, 483, 2185, 3076, 3806, 4363, 4617, 4762, 4991, 5011, 5034, 5058, 5085, 5135, 5471, 5479, 5558, 5578], 'had': [113, 385, 3664, 5027], 'significant': [114, 386, 2940, 3505, 4758], 'basal': [115, 387, 5007], 'inhibited': [119, 125, 391, 398, 1456, 3822, 5139], 'Ca2+.Rho-specific': [121], 'GDP': [122, 142, 395, 415, 564, 585, 1009, 1039, 1452, 1460, 1779, 5359], 'dissociation': [123, 143, 396, 416, 565, 586, 1010, 1040, 1453, 1461, 1780, 5360], 'inhibitor': [124, 397, 1011, 1041, 1462, 1781], 'stimulation': [127, 140, 400, 413, 2942, 3038, 3107, 3520, 3700, 4129, 4466, 4609, 4759, 4792, 5132, 5202, 5235, 5285, 5297, 5481], 'cytosol.': [138, 205, 411, 478, 4579, 4849, 4957], 'inhibitor-treated': [144, 417], 'could': [146, 419, 4567, 4947, 5087, 5137, 5255, 5293, 5352, 5451, 5499, 5707, 5730, 5747], 'be': [147, 255, 420, 528, 908, 1053, 1185, 1238, 1496, 3344, 3966, 4568, 4809, 4815, 4949, 5088, 5138, 5353, 5453, 5500, 5572, 5666, 5912, 5941, 5953], 'partially': [148, 421, 4016, 5198], 'recovered': [149, 422], 'addition': [152, 425, 2487, 2561, 3043, 4628], 'recombinant': [154, 427, 1618, 4007, 4048, 4169, 4190, 4379, 5206, 5250], '(RhoA,': [157, 430, 2844, 5096, 5252], 'Rac1,': [158, 431, 1767, 3918, 3933, 3949, 5097, 5336], 'CDC42Hs).': [159, 432], 'Rac1': [162, 182, 435, 455, 1575, 3984, 4030, 4051, 4213, 5278, 5450], 'also': [164, 207, 437, 480, 907, 1402, 3156, 3361, 3411, 3954, 3963, 4053, 4076, 4122, 4496, 4837, 4948, 5101, 5166, 5213, 5328, 5410, 6015], 'stimulatory': [165, 438, 3667], 'untreated': [167, 440, 5262, 5301], 'membranes.': [168, 241, 441, 514, 1484, 4199, 4277, 5302, 5459, 5681, 5927], 'However,': [169, 442, 3179, 3826, 4506, 4778, 4932, 5005, 5372, 5531, 5928], 'Western': [170, 443, 2700, 2836, 3905, 4342, 5373], 'blot': [171, 444], 'analysis': [172, 445], 'RhoA,': [179, 452, 1765, 3915, 3981, 4008, 4074, 4210, 5207, 5335, 5408, 5432], 'or': [183, 456, 1693, 2400, 2462, 2540, 2690, 3427, 3527, 3935, 4381, 4384, 4768, 4805, 4927, 4954, 5074, 5261, 5458, 5519, 5764], 'CDC42Hs,': [184, 457, 5995], 'suggesting': [185, 458], 'protein': [193, 466, 916, 989, 992, 1019, 1022, 1241, 1334, 1342, 1410, 1512, 3591], 'involved': [194, 467, 1513], 'GTP-dependent': [196, 469, 1440], 'ARF': [206, 223, 479, 496, 1007, 1037, 3180, 3222, 3286, 3353, 3406, 3550, 4361, 4391, 4625, 4827, 4872, 4878, 4922, 4929, 5070, 5102, 5476, 5498, 5520, 5528, 5676, 5765, 5788, 5930], 'GTPγS,': [216, 489, 4037], 'combination': [219, 492, 4386], 'synergistic': [226, 499, 4176, 5493], 'effect.': [227, 500], 'These': [228, 501, 4580, 5036, 5460], 'results': [229, 502, 3922, 4813, 5164, 5593, 5778], 'show': [230, 503, 3380, 5243], 'ARF-dependent': [234, 507], 'both': [238, 511, 2856, 4595, 5227, 5527, 5692, 5924, 5968], 'contain': [244, 517], 'another': [245, 518, 2229, 4829, 5523, 5549, 5862], 'for': [248, 521, 1357, 2004, 2022, 2036, 2043, 2150, 2160, 2210, 2307, 2322, 2414, 2470, 2538, 2543, 2713, 2743, 2788, 2800, 3352, 3447, 3467, 3997, 4223, 4232, 4303, 4316, 4401, 4502, 5347, 5668, 5955, 5984, 6006, 6019], 'which': [249, 522, 912, 932, 1234, 3317, 3719, 4910, 5515], 'appears': [253, 526, 5910], 'to': [254, 527, 596, 771, 910, 1052, 1184, 1237, 1616, 1724, 2178, 2188, 2239, 2245, 2367, 2428, 2662, 2667, 2868, 3056, 3074, 3147, 3183, 3232, 3319, 3343, 3379, 3440, 3490, 3539, 3590, 3594, 3606, 3707, 3716, 3768, 3860, 3914, 3965, 4085, 4276, 4337, 4440, 4516, 4571, 4586, 4826, 4830, 4841, 4941, 5197, 5265, 5281, 5300, 5319, 5321, 5355, 5419, 5517, 5526, 5557, 5563, 5567, 5589, 5719, 5911, 5940, 5946], 'RhoA.': [256, 529, 1515], 'data': [258, 531, 3989, 5037], 'suggest': [259, 532, 5894], 'existence': [261, 534, 1147, 5581, 5735, 5896], 'at': [263, 536, 1604, 1850, 1911, 2007, 2018, 2032, 2085, 2468, 2716, 2786, 2796, 3680, 3722, 4230, 4301, 4312], 'least': [264, 537], 'two': [265, 538, 4255, 4417, 4581, 4821, 4903, 5047, 5506], 'different': [266, 539, 4904, 5029, 5042, 5573, 5583, 5592], 'isozymes': [268, 541, 5044, 5585, 5738, 5899], 'Ca2+.': [393], 'Rho-specific': [394, 1008, 1038, 1459, 1778, 5141, 5192, 5228], '1The': [548, 569], 'abbreviations': [549, 570], 'are:PLDphospholipase': [551, 572], 'DG': [552, 573], 'proteinGTP-binding': [553, 574], 'proteinSMGsmall': [554, 575], 'proteinGTPγSguanosine': [556, 577], '0-(3-thiotriphosphate)PCphosphatidylcholinePEphosphatidyl': [558, 579], 'ethanolaminePIP2phosphatidylinositol': [559, 580], '4,5-bisphosphatePEthphosphatidylethanolHAPhydroxylapatiteARFADP': [560, 581], 'factorsARFsoluble': [562, 583], 'ARFRho-GDIRho-specific': [563, 584], 'inhibitorGSTglutathione': [566, 587], 'S-transferasePAphosphatidic': [567, 588], 'acid.': [568, 589, 1015, 1045], 'catalyzes': [590], 'hydrolysis': [592, 4612], '(PC)': [595], 'phosphatidic': [597, 1014, 1044], 'acid': [598, 2494, 3052], '(PA)': [599], 'choline': [601], 'has': [603, 768, 1049, 1401, 1473, 1488, 3071, 3603, 3857, 4480, 5534], 'been': [604, 696, 769, 1050, 1489, 3072, 3604, 3858, 4482, 5536], 'implicated': [605], 'signal': [607], 'transduction': [608], 'variety': [611], 'cell': [613, 775, 1445, 3080, 3612, 4436, 4494], 'types': [614, 3081, 4437, 5507], '(1Exton': [615, 698], 'J.H.': [616, 671, 699, 754, 782, 961, 1079, 1099, 1647, 1802, 3083, 5879], 'J.': [617, 634, 700, 717, 842, 858, 877, 893, 947, 976, 1080, 1100, 1129, 1161, 1225, 1247, 1261, 1370, 1386, 1424, 1648, 1698, 1735, 1738, 1754, 1803, 2580, 2928, 3752, 3793, 3880, 4663, 4744, 4961, 4972, 5117, 5149, 5848, 5880, 6000, 6017], 'Biol.': [618, 701, 843, 859, 878, 894, 1081, 1101, 1130, 1162, 1371, 1387, 1425, 1649, 1740, 1804, 2929, 3753, 3794, 3881, 4745, 5118, 5150, 5849, 5881], 'Chem.': [619, 702, 844, 860, 879, 895, 1082, 1102, 1131, 1163, 1372, 1388, 1426, 1650, 1805, 2930, 3754, 3795, 3882, 4746, 5119, 5151, 5850, 5882], '1990;': [620, 635, 703, 718, 880], '265:': [621, 704, 881], '1-4Abstract': [622, 705], 'Full': [623, 706, 826, 848, 864, 883, 899, 1086, 1106, 1135, 1167, 1287, 1376, 1392, 1430, 1654, 1809, 2385, 2524, 2885, 2934, 2992, 3029, 3654, 3758, 3799, 3886, 4150, 4534, 4644, 4701, 4750, 5123, 5155, 5627, 5805, 5854, 5886], 'Text': [624, 707, 827, 849, 865, 884, 900, 1087, 1107, 1136, 1168, 1288, 1377, 1393, 1431, 1655, 1810, 2386, 2525, 2886, 2935, 2993, 3030, 3655, 3759, 3800, 3887, 4151, 4535, 4645, 4702, 4751, 5124, 5156, 5628, 5806, 5855, 5887], 'PDF': [625, 708, 828, 850, 866, 885, 901, 1088, 1108, 1137, 1169, 1289, 1378, 1394, 1432, 1656, 1811, 2387, 2526, 2887, 2936, 2994, 3031, 3656, 3760, 3801, 3888, 4152, 4536, 4646, 4703, 4752, 5125, 5157, 5629, 5807, 5856, 5888], 'PubMed': [626, 638, 652, 665, 678, 709, 721, 735, 748, 761, 789, 811, 829, 851, 886, 902, 951, 967, 981, 1071, 1089, 1109, 1120, 1138, 1170, 1213, 1251, 1265, 1290, 1319, 1379, 1395, 1433, 1657, 1712, 1812, 1898, 2344, 2388, 2527, 2635, 2888, 2917, 2937, 2995, 3032, 3090, 3575, 3635, 3657, 3761, 3802, 3889, 3900, 4153, 4537, 4647, 4676, 4704, 4733, 4753, 5126, 5158, 5630, 5659, 5808, 5837, 5857, 5889], 'Google': [627, 641, 655, 668, 681, 710, 724, 738, 751, 764, 792, 814, 832, 852, 867, 887, 903, 954, 970, 984, 1074, 1090, 1110, 1123, 1139, 1171, 1216, 1232, 1254, 1268, 1293, 1322, 1380, 1396, 1434, 1658, 1715, 1813, 1901, 2347, 2391, 2530, 2588, 2638, 2891, 2920, 2938, 2998, 3035, 3093, 3578, 3638, 3660, 3762, 3803, 3890, 3903, 4156, 4540, 4650, 4679, 4707, 4736, 4754, 5127, 5159, 5633, 5662, 5811, 5840, 5858, 5890], 'Scholar,': [628, 642, 656, 669, 711, 725, 739, 752, 793, 815, 833, 853, 868, 888, 955, 971, 1075, 1091, 1111, 1124, 1217, 1255, 1294, 1381, 2892, 2921, 3639, 3891, 4651, 4708, 4737, 5634, 5812, 5841], '2Billah': [629, 712], 'M.M.': [630, 713, 1160, 1205, 1890, 2336, 2627, 3627], 'Anthes': [631, 714, 1153], 'J.C.': [632, 715, 1154, 1197, 1882, 2328, 3619], 'Biochem.': [633, 716, 946, 1226, 1246, 1260, 2581], '269:': [636, 719, 1652, 1807, 5884], '281-291Crossref': [637, 720], 'Scopus': [639, 653, 666, 679, 722, 736, 749, 762, 790, 812, 830, 952, 968, 982, 1072, 1121, 1214, 1230, 1252, 1266, 1291, 1320, 1713, 1899, 2345, 2389, 2528, 2586, 2636, 2889, 2918, 2996, 3033, 3091, 3576, 3636, 3658, 3901, 4154, 4538, 4648, 4677, 4705, 4734, 5631, 5660, 5809, 5838], '(701)': [640, 723], '3Shukla': [643, 726], 'S.D.': [644, 727], 'Halenda': [645, 728], 'S.P.': [646, 729], 'Life': [647, 730], 'Sci.': [648, 731, 4669], '1991;': [649, 732, 1164, 1210, 1248, 1709, 1895, 2341, 3632], '48:': [650, 733, 979], '851-866Crossref': [651, 734], '(142)': [654, 737], '4Cockcroft': [657, 740], 'S.': [658, 741, 876, 1223, 1259, 1276, 1296, 1592, 2374, 2513, 2874, 2894, 2981, 3018, 3552, 3643, 4139, 4523, 4633, 4671, 4690, 4710, 5616, 5636, 5794, 5814], 'Biochim.': [659, 672, 742, 755, 783, 1064, 1114, 1206, 1891, 2337, 2628, 3084, 3628], 'Biophys.': [660, 673, 743, 756, 784, 1065, 1115, 1207, 1892, 2338, 2629, 3085, 3629], 'Acta.': [661, 674, 744, 757, 785, 1116, 3086], '1992;': [662, 745, 845, 896, 1083, 1227, 1262, 3883], '1113:': [663, 746], '135-160Crossref': [664, 747], '(243)': [667, 750], '5Exton': [670, 753], '1994;': [675, 758, 786, 1316, 1651, 1806, 2914, 3087, 3572, 4673, 4730, 5656, 5834, 5883], '1212:': [676, 759, 787, 3088], '26-42Crossref': [677, 760, 788, 3089], '(914)': [680, 763, 791, 3092], 'Scholar).': [682, 904, 985, 1172, 1269, 1397, 1435, 1659, 1716, 1745, 1814, 1902, 2348, 2392, 2531, 2589, 2639, 2999, 3036, 3579, 4157, 4680, 5160, 5891], 'During': [683], 'last': [685], 'decade,': [686], 'large': [688], 'number': [689], 'agonists': [691], 'stimulate': [693, 3075, 3607, 5478], 'have': [695, 1324, 3294, 5939], 'identified': [697, 1345, 4483], 'Scholar),': [765, 1140, 1233, 3094, 3661, 3763, 3804, 3904, 4541, 5663], 'PA': [767, 905, 2647, 2668], 'proposed': [770, 1236], 'regulate': [772, 5947], 'DNA': [773], 'synthesis,': [774], 'proliferation,': [776], 'other': [778, 4685, 5363, 5552, 5684, 5737], 'cellular': [779, 5903], 'functions': [780], '(5Exton': [781, 3082], '6Moolenaar': [794], 'W.H.': [795], 'Kruijer': [796], 'W.': [797, 3875], 'Tilly': [798], 'B.C.': [799], 'Verlaan': [800], 'I.': [801, 1306, 1308, 2904, 2906, 3562, 3564, 4720, 4722, 5646, 5648, 5824, 5826], 'Bierman': [802], 'A.J.': [803], 'de': [804], 'Laat': [805], 'S.W.': [806], 'Nature.': [807, 3896], '1986;': [808, 1389], '323:': [809], '171-173Crossref': [810], '(378)': [813], '7Yu': [816], 'C.-L.': [817], 'Tsai': [818, 1699, 1725, 1752, 5998], 'M.H.': [819], 'Stacey': [820], 'D.W.': [821], 'Cell.': [822, 1283, 2381, 2520, 2881, 2988, 3025, 3650, 4146, 4530, 4640, 4697, 5623, 5801], '1988;': [823, 1117, 1741, 2632], '52:': [824], '63-71Abstract': [825], '(210)': [831], '8Kondo': [834], 'T.': [835, 841, 892, 3877], 'Inui': [836], 'H.': [837, 870, 4965, 4973], 'Konishi': [838], 'F.': [839, 3895], 'Inagami': [840], '267:': [846, 897, 1084, 3884], '23609-23616Abstract': [847], '9Murayama': [854], 'Y.': [855, 1824, 5977], 'Ui': [856], 'M.': [857, 973, 1243, 1645, 1706, 1737, 1800, 2248, 2625, 4657, 4665, 4969, 5877], '1989;': [861, 1132], '262:': [862, 1104], '12463-12467Abstract': [863], '10Zhang': [869], 'Desai': [871], 'N.N.': [872], 'Murphey': [873], 'J.M.': [874], 'Speigel': [875], '21309-21316Abstract': [882], '11Fukami': [889], 'K.': [890, 1733], 'Takenama': [891], '10988-10993Abstract': [898], 'can': [906, 1495, 4814], 'metabolized': [909], 'diacyglycerol,': [911], 'turn': [914], 'stimulates': [915], 'kinase': [917], 'C.': [918, 1280, 2378, 2517, 2878, 2985, 3022, 3647, 4143, 4527, 4637, 4694, 5620, 5798], 'A': [919, 1398, 1578, 1924, 3127, 3272, 3426, 4251, 4273, 5700], 'unique': [920], 'property': [921], 'is': [924, 938, 1142, 1330, 1507, 1514, 1669, 3537, 4259, 4447, 4457, 4470, 4939, 5540, 5608, 5677, 5753, 5770, 5921, 5931], 'its': [925, 1146, 1352, 3095, 4465], 'catalysis': [926], 'transphosphatidylation': [929], 'reaction': [930, 2552], 'phosphatidyl': [934, 997, 1027], 'moeity': [935], 'phospholipids': [937, 2651], 'accepted': [939], 'primary': [942, 2747], 'alcohol': [943], '(12Dawson': [944], 'R.M.C.': [945], '1967;': [948], '102:': [949], '205-210Crossref': [950], '(205)': [953], '13Bocckino': [956], 'S.B.': [957, 1093], 'Wilson': [958, 1096], 'P.B.': [959, 1097], 'Exton': [960, 1078, 1098, 1646, 1801, 5878], 'FEBS': [962], 'Lett.': [963], '1987;': [964, 978, 1103], '225:': [965], '201-204Crossref': [966], '(77)': [969], '14Kobayashi': [972], 'Kanfer': [974, 1062], 'J.N.': [975, 1063], 'Neurochem.': [977], '1597-1603Crossref': [980], '(263)': [983], 'phospholipase': [986, 1016], '0-(3-thiotriphosphate)': [995, 1025], 'ethanolamine': [998, 1028], '4,5-bisphosphate': [1000, 1030, 1532], 'phosphatidylethanol': [1001, 1031, 1522], 'hydroxylapatite': [1002, 1032, 3371], 'soluble': [1006, 1036, 4549, 4598], 'glutathione': [1012, 1042], 'S-transferase': [1013, 1043], 'Although': [1046, 3600, 4092, 4860], 'shown': [1051, 1183, 3165, 5537], 'associated': [1054], 'mammalian': [1058], 'cells': [1059, 1472, 1553, 1615, 1832, 1915, 1952, 2011, 2862, 3545, 4428, 4456], '(15Chalifour': [1060], 'R.J.': [1061], 'Res.': [1066, 1208, 1893, 2339, 2630, 3630], 'Commun.': [1067, 1209, 1894, 2340, 2631, 3631], '1980;': [1068], '96:': [1069], '742-747Crossref': [1070], '(55)': [1073], '16Siddiqui': [1076], 'R.A.': [1077, 1367, 1383, 3879], '5755-5761Abstract': [1085], '17Bocckino': [1092], 'Blackmore': [1094], 'P.F.': [1095], '15309-15315Abstract': [1105], '18Martin': [1112], 'T.W.': [1113, 1126], '962:': [1118], '282-296Crossref': [1119], '(106)': [1122], '19Martin': [1125], 'Michaelis': [1127], 'K.M.': [1128], '264:': [1133], '8847-8856Abstract': [1134], 'there': [1141, 3192, 5943], 'one': [1143, 4430, 4824, 5513, 5575], 'report': [1144, 3731], '(20Wang': [1151], 'P.': [1152, 1199, 1884, 2330, 3621], 'Seigel': [1155], 'M.I.': [1156, 1201, 1886, 2332, 3623], 'Egan': [1157, 1202, 1887, 2333, 3624], 'R.W.': [1158, 1203, 1888, 2334, 3625], 'Billah': [1159, 1204, 1889, 2335, 2626, 3626], '266:': [1165], '14877-14880Abstract': [1166], 'In': [1173, 1485, 2866, 3000, 3049, 3145, 3208, 3690, 3726, 3971, 4033, 4907, 5772], 'cells,': [1175], 'reported': [1179, 3073, 3605, 3859], 'regulated': [1186], '(21Anthes': [1196, 1881, 2327, 3618], 'Wang': [1198, 1883, 2329, 3620], 'Siegel': [1200, 1885, 2331, 2624, 3622], '175:': [1211, 1896, 2342, 3633], '236-243Crossref': [1212, 1897, 2343, 3634], '(44)': [1215, 1900, 2346, 3637], '22Geny': [1218], 'B.': [1219, 1257, 1302, 2900, 3558, 4716, 5642, 5820], 'Fensome': [1220, 1299, 2897, 3555, 4713, 5639, 5817], 'A.': [1221, 1300, 1581, 2196, 2813, 2898, 3556, 3873, 4326, 4672, 4714, 4964, 5640, 5818], 'Cockcroft': [1222, 1258], 'Eur.': [1224], '215:': [1228], '389-396Crossref': [1229], '(35)': [1231], 'G': [1240, 1333, 1409, 1511, 2842, 5239], '(23Xie': [1242], 'Dubyak': [1244], 'G.R.': [1245], '278:': [1249], '81-89Crossref': [1250], '(41)': [1253], '24Geny': [1256], '284:': [1263], '531-538Crossref': [1264], '(83)': [1267], 'Two': [1270], 'recent': [1271, 1399], 'reports': [1272, 2870], '(25Brown': [1273, 2371, 2510, 2871, 2978, 4136, 4520, 4687, 5613, 5791], 'H.A.': [1274, 2372, 2511, 2872, 2979, 3016, 3641, 4137, 4521, 4631, 4688, 5614, 5792], 'Gutowski': [1275, 2373, 2512, 2873, 2980, 3017, 3642, 4138, 4522, 4632, 4689, 5615, 5793], 'Moomaw': [1277, 2375, 2514, 2875, 2982, 3019, 3644, 4140, 4524, 4634, 4691, 5617, 5795], 'C.R.': [1278, 1702, 2376, 2515, 2876, 2983, 3020, 3645, 4141, 4525, 4635, 4692, 5618, 5796], 'Slaughter': [1279, 2377, 2516, 2877, 2984, 3021, 3646, 4142, 4526, 4636, 4693, 5619, 5797], 'Sternweis': [1281, 2379, 2518, 2879, 2986, 3023, 3648, 4144, 4528, 4638, 4695, 5621, 5799], 'P.C.': [1282, 2380, 2519, 2880, 2987, 3024, 3649, 4145, 4529, 4639, 4696, 5622, 5800], '1993;': [1284, 1427, 2382, 2521, 2882, 2931, 2989, 3026, 3651, 3755, 3796, 3897, 4147, 4531, 4641, 4698, 4747, 5120, 5152, 5624, 5802, 5851], '75:': [1285, 2383, 2522, 2883, 2990, 3027, 3652, 4148, 4532, 4642, 4699, 5625, 5803], '1137-1144Abstract': [1286, 2384, 2523, 2884, 2991, 3028, 3653, 4149, 4533, 4643, 4700, 5626, 5804], '(819)': [1292, 2390, 2529, 2890, 2997, 3034, 3659, 4155, 4539, 4649, 4706, 5632, 5810], '26Cockcroft': [1295, 2893, 4709, 5635, 5813], 'Thomas': [1297, 2895, 3553, 4711, 5637, 5815], 'G.M.H.': [1298, 2896, 3554, 4712, 5638, 5816], 'Geny': [1301, 2899, 3557, 4715, 5641, 5819], 'Cunningham': [1303, 2901, 3559, 4717, 5643, 5821], 'E.': [1304, 1786, 2301, 2902, 3560, 4718, 5644, 5822], 'Gout': [1305, 2903, 3561, 4719, 5645, 5823], 'Hiles': [1307, 2905, 3563, 4721, 5647, 5825], 'Tolly': [1309, 2907, 3565, 4723, 5649, 5827], 'I.F.': [1310, 2908, 3566, 4724, 5650, 5828], 'Truong': [1311, 2909, 3567, 4725, 5651, 5829], 'O.': [1312, 2910, 3568, 4726, 5652, 5830], 'Hsuan': [1313, 2911, 3569, 4727, 5653, 5831], 'J.J.': [1314, 2912, 3570, 4728, 5654, 5832], 'Science.': [1315, 2913, 3571, 4729, 5655, 5833], '263:': [1317, 2915, 3573, 4731, 5657, 5835], '523-526Crossref': [1318, 2916, 3574, 4732, 5658, 5836], '(584)': [1321, 2919, 3577, 4735, 5661, 5839], 'Scholar)': [1323, 2939, 4755, 5128, 5859], 'revealed': [1325, 1474, 3310, 5375], '(SMG)': [1335], '(ARF).': [1339], 'This': [1340, 1436, 1815, 2197, 2640, 3309, 3536, 4977, 5303], '21-kDa': [1341], 'first': [1344], 'purified': [1347, 1624, 1690, 1784, 5061], 'basis': [1350], 'cofactor': [1356], 'cholera': [1358], 'toxin-catalyzed': [1359], 'α-subunit': [1364], 'Gs(28Kahn': [1366], 'Gilman': [1368, 1384], 'A.G.': [1369, 1385], '1984;': [1373], '259:': [1374], '6228-6234Abstract': [1375], '29Kahn': [1382], '261:': [1390], '7906-7911Abstract': [1391], 'study': [1400, 1437, 3114], 'suggested': [1403], 'involvement': [1405, 3150, 3734, 4876, 5464], 'membrane-associated': [1408, 3494], 'family': [1414, 3739, 5095, 5238, 5393], 'regulation': [1417, 3356, 3743, 4442, 4590, 4881, 5469, 5964], '(27Bowman': [1418, 3746, 3787, 5111, 5143], 'E.P.': [1419, 2923, 3747, 3788, 4739, 5112, 5144, 5843], 'Uhlinger': [1420, 2924, 3748, 3789, 4740, 5113, 5145, 5844], 'D.J.': [1421, 2925, 3749, 3790, 4741, 5114, 5146, 5845], 'Lambeth': [1422, 2926, 3750, 3791, 4742, 5115, 5147, 5846], 'J.D.': [1423, 2927, 3751, 3792, 4743, 5116, 5148, 5847], '268:': [1428, 2932, 3756, 3797, 4748, 5121, 5153, 5852], '21509-21512Abstract': [1429, 2933, 3757, 3798, 4749, 5122, 5154, 5853], 'preparations': [1446], 'nonspecific': [1451], 'stimulator': [1454], '(GDI).': [1463], 'present': [1465, 5079, 5609, 5693, 5913], 'investigation': [1466], 'well': [1482, 4551], 'addition,': [1486, 3209], 'it': [1487, 1668, 3340, 4839, 5194, 5533, 5570, 5587, 5664, 5937], 'found': [1490, 3172, 3964, 4544, 4558, 5167, 5922], 'membrane-bound': [1493], 'cytosol,': [1504, 1667, 2356, 2461, 2955, 3819, 4100], 'evidence': [1506, 4887], 'presented': [1508], 'Dipalmitoylphosphatidylcholine': [1516], '(dipalmitoyl-PC),': [1517], '(PE),': [1519], 'PA,': [1520], '(PEth)': [1523], 'purchased': [1525], 'from': [1526, 1538, 1549, 1556, 1564, 1570, 1665, 1691, 1771, 1785, 1823, 2591, 2620, 2705, 3296, 3374, 3407, 3436, 3929, 4083, 4242, 4274, 4858, 4895, 4899, 4914, 5417, 5574, 5933], 'Avanti': [1527], 'Polar': [1528], 'Lipids': [1529, 2590], 'Corp.': [1530], 'Phosphatidylinositol': [1531], '(PIP2)': [1533], 'obtained': [1537, 1555, 2029, 4889, 5594], 'Boehringer': [1539], 'Mannheim.': [1540], '[9,10-3H]Myristic': [1541], 'acid,': [1542, 1874], 'dipalmitoyl': [1543], '[2-': [1544], 'palmitoyl-9,10-3H]phosphatidylcholine,': [1545], 'dipalmitoylphosphatidyl[methyl-3H]choline': [1547], 'DuPont': [1550], 'NEN.': [1551], 'ATCC.': [1557], 'DEAE': [1558, 2226, 3367, 3443, 3585, 3695, 4896, 4988], 'Sephacel': [1559], 'Superdex': [1561, 2191, 3269], '200': [1562, 2192, 2489, 3270], 'Pharmacia': [1565], 'Biotech': [1566], 'Inc.': [1567], 'Hydroxylapatite': [1568], 'CalBiochem.': [1571], 'cDNAs': [1573], '(gifts': [1579], 'Hall,': [1582], 'University': [1583], 'College,': [1584], 'London)': [1585], 'CDC42': [1588, 3936, 3952, 3979, 4028, 4063, 4095, 4935, 5075, 5338], '(a': [1589, 1683], 'gift': [1590], 'Munemitsu,': [1593], 'Onxy': [1594], 'Pharmaceuticals)': [1595], 'provided': [1597], 'modified': [1600, 1675, 2619, 3863], 'Glu-Glu': [1601, 1627], 'epitope': [1602], 'tag': [1603], 'N': [1606], 'terminus,': [1607], 'cloned': [1608], 'into': [1609, 1613, 5782], 'pAcC13,': [1610], 'transfected': [1612], 'Sf9': [1614, 1666], 'produce': [1617], 'baculovirus,': [1619], 'monoclonal': [1628], 'antibody': [1629, 2748], 'affinity': [1630], 'column': [1631, 2100, 2106, 2193, 2261, 2358, 2463, 2546, 3153, 3376, 3410], 'described': [1633, 1880, 2326, 2509, 2574, 2973, 4247, 4345, 4409], 'Malcolm': [1635], 'et': [1636, 1726, 2369, 2976, 4518, 5109], 'al.': [1637, 1727, 2370, 2977, 4519, 5110], '(30Malcolm': [1638, 1793, 5870], 'K.C.': [1639, 1794, 5871], 'Ross': [1640, 1795, 5872], 'A.H.': [1641, 1796, 5873], 'Qui': [1642, 1797, 5874], 'R.-G.': [1643, 1798, 4967, 5875], 'Symons': [1644, 1799, 5876], '25951-25954Abstract': [1653, 1808, 5885], 'Since': [1660, 3069, 3851], 'prepared': [1664, 1878, 2365], 'likely': [1670], 'they': [1672, 5351], 'partly': [1674], 'prenylation.': [1677], 'Soluble': [1678], '(sARF)': [1682, 3223], 'mixture': [1684, 2413, 4164], 'ARF1': [1686], 'ARF3)': [1688], 'bovine': [1692, 1847, 2219, 2500, 2733, 3220, 3388, 4125, 4172, 4382, 4770, 4952], 'rat': [1694, 4955], 'brain': [1695, 4953], '(31Moss': [1697], 'S.-C.': [1700, 1729, 1751, 5997], 'Price': [1701], 'Bobak': [1703], 'D.A.': [1704], 'Vaughan': [1705, 1736, 4664], 'Methods': [1707], 'Enzymol.': [1708], '195:': [1710], '243-256Crossref': [1711], '(10)': [1714], 'Polyclonal': [1717], 'antibodies': [1718, 2839, 3913], 'raised': [1720], 'against': [1721, 1761, 1819, 2840, 5994], 'sARF': [1722, 3389, 4173, 4383, 4771, 5212, 6010, 6012], 'according': [1723, 2366, 4515], '(32Tsai': [1728], 'Adamik': [1730], 'R.': [1731, 1827, 4959, 5980], 'Williamson': [1732], 'Moss': [1734, 1755, 4662, 6001], 'Cell': [1739], '107': [1742], '(abstr.):': [1743], '4017Google': [1744], 'Both': [1746, 4990], 'kind': [1748, 5985], 'gifts': [1749, 1822, 5986, 6008], '(National': [1756, 6002], 'Institutes': [1757, 6003], 'Health).': [1759], 'Antibodies': [1760], 'C-terminal': [1762], 'peptides': [1763], 'RhoB,': [1766, 2845, 3916, 5433], 'Rac2': [1769], 'Santa': [1772], 'Cruz': [1773], 'Biotechnology': [1774], 'Corporation.': [1775], 'Glutathione': [1776], 'S-transferase-fused': [1777], '(GST-Rho-GDI)': [1782], 'coli': [1787], 'transformed': [1788], 'relevant': [1791], 'plasmid': [1792, 1816, 5990], 'antiserum': [1818, 5993], 'Zheng': [1825, 5978], 'Cerione': [1828, 3878, 5981], '(Cornell': [1829, 5982], 'University).': [1830], 'maintained': [1834], 'suspension': [1836], 'culture': [1837], 'RPMI': [1839], '1640': [1840], 'medium': [1841], '(Cell': [1842], 'Gro)': [1843], 'containing': [1844, 2459, 3176, 3423], '10%': [1845, 2492], 'fetal': [1846], 'serum': [1848, 2501, 2734, 2740], '(Sigma),': [1849], '37°C': [1851, 2469, 4231, 4302], 'humidified': [1854], 'atmosphere': [1855], '5%': [1857], 'CO2and': [1858], '95%': [1859], 'air.': [1860], 'Cells': [1861, 1869], 'harvested': [1863], 'confluent': [1865], '(1': [1866, 2091, 2303], '×': [1867, 1917, 2020, 2034, 2102, 2798, 4314], '106cells/ml).': [1868], 'Membranes': [1903, 2025, 2078], 'aliquoted': [1905, 2080], '(0.5-1.0': [1906], 'mg': [1907, 2092], 'protein/ml)': [1908, 2094], 'stored': [1910, 2084], '−80°C.': [1912, 2086], 'Harvested': [1913], '(4-6': [1916], '109)': [1918], 'washed': [1920, 2050, 2108, 2264, 2809, 4322], 'twice': [1921, 2051, 2810, 4323], 'buffer.': [1923, 2203, 2751], '(25': [1925, 2112, 2268], 'HEPES': [1928, 1961, 2058, 2115, 2271, 2779], '(pH': [1929, 1962, 2059, 2116, 2272, 2436, 2780], '7.2),': [1930, 2060, 2437], '125': [1931], 'NaCl,': [1934, 2068], '2.5': [1935], 'KC1,': [1938], '0.7': [1939], 'MgCl,': [1942], '0.5': [1943, 2069], 'EGTA,': [1946, 1967, 2072, 2121, 2441], '10': [1947, 1979, 2023, 2061, 2422, 2782, 2801, 3247, 3595, 4317, 5273], 'glucose).': [1950], 'Washed': [1951], 'resuspended': [1954, 2596, 4329], 'buffer': [1956, 2053, 2110, 2143, 2195, 2235, 2266, 2300, 2431, 2774, 2820, 4325, 4334], 'B': [1957], '(5': [1958], '7.4),': [1963, 2117, 2273], '1': [1964, 1968, 2118, 2123, 2274, 2446, 2714, 2864, 3047, 3067, 3532, 5699], 'dithiothreitol,': [1971, 2277, 2449], '250': [1972], 'sucrose,': [1975], '12': [1976, 2103], 'μg/ml': [1977, 1980, 1983, 1988], 'leupeptin,': [1978], 'aprotinin,': [1981], '20': [1982, 1987, 2005], '4-amidinophenylmethanesulfonyl': [1984], 'fluoride,': [1985], 'antipain)': [1989], 'disrupted': [1992], 'bomb': [1995], 'rapid': [1997], 'decompression': [1998], 'after': [1999, 4004, 4987], 'equilibration': [2000], 'N2at': [2002], '4°C': [2003, 2787], 'min': [2006, 2472, 4234], '500': [2008, 2019], 'psi.': [2009], 'Unbroken': [2010], 'nuclei': [2013], 'removed': [2015], 'centrifugation': [2017, 2031], 'g': [2021, 2035, 2799, 4315], 'min.': [2024, 2038, 2790, 2802, 4225, 4403], '125,000': [2033], '90': [2037], 'Supernatant': [2039], '(cytosol)': [2040], 'chromatography,': [2044, 2170], 'pellet': [2047], '(membranes)': [2048], 'C': [2054], '(50': [2055, 2432, 4299], 'KCl,': [2064, 2445], '5': [2065], '3.5': [2074], 'MgCl2).': [2077], '(5-10': [2081], 'mg/ml)': [2082], '150': [2087], 'ml': [2088, 2180], 'loaded': [2096, 2254], 'DEAE-Sephacel': [2099, 3125], '(2.5': [2101], 'cm).': [2104], 'dithiothreitol),': [2126], 'bound': [2129], 'eluted': [2132, 2199, 2288, 3134, 3396], '200-ml': [2135], 'linear': [2136, 2291, 3466], 'gradient': [2137, 2292, 2691, 3142], 'NaCl': [2139, 2244, 3141], '(0-0.8': [2140], 'M)': [2141, 2298], 'D.': [2144, 3867, 4653], 'Fractions': [2145, 2302, 3373], '(3': [2146], 'ml)': [2147, 2207, 2304], 'assayed': [2149, 2209, 2306, 2321, 3211, 3300, 3614, 3673, 3809, 3828, 4509], 'activity,': [2152, 3119, 3190, 3316, 3415, 3808, 4180], 'active': [2154, 2174, 2225, 3433], 'fractions': [2155, 2175, 2205, 2227, 2464, 3154, 3175, 3186, 3215, 3230, 3283, 3303, 3368, 3422, 3435, 4908], 'pooled': [2157, 3240], 'further': [2161, 3262, 3348, 3448, 4069, 4587, 5403, 5973], 'purification': [2162], 'characterization': [2164, 3449], 'PLD.': [2166, 3453, 5035, 5472], 'For': [2167, 2417, 2476, 2532, 2699, 2814, 5602], 'gel': [2168, 2682, 3265, 4339], 'filtration': [2169, 3266], 'pool': [2172, 2223, 2251, 3260, 3365, 3431], 'concentrated': [2177, 3242, 3259, 3364, 3430], '3': [2179, 2438, 2450], 'using': [2181, 2360, 2719, 2755, 2838, 3102, 3158, 3243, 3267, 3615, 3810, 3834, 3912, 5597], 'YM10': [2183], 'Amicon': [2184, 3245], 'applied': [2187], '150-ml': [2190], 'same': [2202, 3409], 'Column': [2204], '(2': [2206], 'sARF.': [2220, 2315, 3308], 'Alternatively,': [2221], '(from': [2228], 'preparation)': [2231], 'diluted': [2233, 2250], '(without': [2237], 'EGTA)': [2238], 'decrease': [2240], 'concentration': [2242, 3517, 3592], '50': [2246, 2279], 'then': [2253], 'onto': [2255, 2602, 2708], '10-ml': [2257], 'hydroxyapatite': [2258], 'column.': [2259, 3271, 3372], 'extensively': [2263, 4434], 'E': [2267], 'NaCl),': [2282], 'adsorbed': [2285], 'material': [2286, 3335], 'potassium': [2294], 'phosphate': [2295, 3403], '(0-150': [2296], '[3H]Myristic': [2316], 'measured': [2352], 'unlabeled': [2354], 'membranes,': [2355, 2460, 3931, 3959, 4061, 5220, 5263, 5386, 5512, 5916, 5936], 'fractions,': [2359], 'phospholipid': [2361, 2412], '(PE/PIP2/PC,': [2362], '16:1.4:1)': [2363], 'vesicles': [2364, 2425], 'Brown': [2368, 2975, 4517], 'Dipalmitoyl[2-': [2393], 'palmitoyl-9-10-3H]PC': [2394], '(0.5': [2395, 2403], 'μCi)': [2396, 2404], '(for': [2397, 2405], '[3H]PEth': [2398, 2533, 3059, 4241], 'formation)': [2399], 'dipalmitoyl[methyl-3H]choline': [2401], 'PC': [2402, 4615, 5722, 5744], '[3H]choline': [2406, 2478], 'release)': [2407], 'included': [2409, 2549], 'each': [2415], 'assay.': [2416], '60-μl': [2419], 'assay': [2420, 2430, 4290, 5726], 'volume,': [2421], 'μl': [2423, 2490, 2497, 2564], 'added': [2427, 5299, 5673], 'HEPES,': [2435], '80': [2442], 'MgCl2,': [2453], 'CaCl2)': [2458], 'incubated': [2467, 2742, 2770, 2818, 4287], '30': [2471, 4233], '(unless': [2473], 'otherwise': [2474], 'indicated).': [2475], 'release': [2479], 'assay,': [2480], 'reactions': [2482, 2556], 'stopped': [2484], 'trichloroacetic': [2493], '100': [2496], '1%': [2499, 2731, 2737, 4239], 'albumin,': [2502], 'mixtures': [2505, 2594], 'processed': [2507], 'formation,': [2534], 'ethanol': [2535], '(1%': [2536], '(v/v)': [2537, 2542, 2738], '2%': [2541], 'fractions)': [2547], 'mixtures,': [2553], 'terminated': [2558], '375': [2563], 'chloroform/methanol/HC1': [2566], '(50:98:2),': [2567], 'lipids': [2570], 'extracted': [2572, 3928, 5190, 5219], '(33Bligh': [2575], 'E.G.': [2576], 'Dyer': [2577], 'W.J.': [2578], 'Can.': [2579], 'Physiol.': [2582], '1959;': [2583], '37:': [2584], '11-17Crossref': [2585], '(41848)': [2587], 'incubation': [2593], 'chloroform/methanol': [2598], '(2:1)': [2599], 'spotted': [2601], 'thin': [2603], 'layer': [2604], 'plates': [2605, 2611, 2659], '(LK6D,': [2606], 'Silica': [2607], 'gel,': [2608], 'Whatman).': [2609], 'developed': [2613, 2754], 'ethyl': [2615], 'acetate/isooctane/acetic': [2616], 'acid/water': [2617], '(50:25:10:50,': [2618], 'Ref.': [2621, 3014], '34Pai': [2622], 'J.K.': [2623], '150:': [2633], '355-364Crossref': [2634], '(97)': [2637], 'solvent': [2641], 'system': [2642], 'gives': [2643], 'better': [2644], 'separation': [2645], 'PEth.': [2649], 'Separated': [2650], 'standards': [2653], 'visualized': [2655], 'thin-layer': [2657], 'exposure': [2661], 'iodine': [2663], 'vapor.': [2664], 'Spots': [2665], 'corresponding': [2666, 3231], 'PEth': [2670, 3458, 3522], 'scraped,': [2672], 'mixed': [2673], 'ready': [2675], 'organic': [2676], 'scintillant': [2677], '(Beckman),': [2678], 'counted.': [2680], 'SDS-polyacrylamide': [2681, 2706, 4338], 'electrophoresis': [2683, 4340], 'performed': [2685, 3911, 4256], '14%': [2687], 'acrylamide': [2688, 2693], 'gels': [2689, 2695, 2707], '10-25%': [2692], 'Novex': [2694], '(Novel': [2696], 'Experimental': [2697], 'Corp.).': [2698], 'analysis,': [2701], 'transferred': [2704], 'Immobilon': [2709], 'P': [2710], '(Millipore)': [2712], 'h': [2715, 2745], '15': [2717, 4224, 4402], 'V': [2718], 'semi-dry': [2721], 'transfer': [2722], 'apparatus': [2723], '(Bio-Rad).': [2724], 'immunoblots': [2726], 'blocked': [2728], 'overnight': [2729], '(w/v)': [2732], 'albumin': [2735], 'goat': [2739], 'blocking': [2750], 'Blots': [2752], 'Vector': [2757], 'stain': [2758], 'alkaline': [2759], 'phosphatase': [2760], 'ABC': [2761], 'kit': [2762], '(Vector': [2763], 'Laboratories,': [2764], 'Burlingame,': [2765], 'CA).': [2766], 'GST-Rho-GDI': [2772, 3780, 5989], 'F': [2775, 2821], '(20': [2776], '7.0),': [2781], 'glutathione)': [2785], '60': [2789], 'After': [2791, 4307], 'incubation,': [2792, 4308], 'centrifuged': [2795, 4311], '14,000': [2797, 4313], 'Supernatants': [2803], 'collected,': [2805], 'solution': [2812], 'controls,': [2815], 'GST-Rho-GDI.': [2826], 'supernatants': [2828, 3909], '(membrane': [2829], 'extracts)': [2830], 'analyzed': [2834], 'blotting': [2837, 3906, 4343, 5374], 'CDC42,': [2846, 3917, 4009, 4211, 5208, 5253, 5435], 'Rac1).': [2848], 'Guanine': [2849], 'nucleotide-sensitive': [2850], '(Fig.': [2863, 3046, 3066, 3143, 3287, 3326, 3390, 3534, 3688, 3781, 3848, 3986, 4031, 4066, 4114, 4132, 4186, 5181, 5429], 'A).': [2865, 3048, 3783], 'contrast': [2867], 'previous': [2869, 3730, 4487], '27Bowman': [2922, 4738, 5842], 'observed': [2947, 3109, 3280, 3541, 3785, 4131, 5162, 5186], 'only': [2957, 4101, 5380, 5436, 5521, 5914], '[3H]dipalmitoyl-PC': [2960], 'employed': [2962], 'together': [2965], 'PE': [2967], 'PIP2in': [2969], 'molar': [2971], 'ratio': [2972], 'PIP2,': [3004, 4790], 'low': [3009], '(data': [3010, 3110, 3482, 3512, 3597, 3943, 3968, 4044], 'shown,': [3012], 'see': [3013, 3713], '25Brown': [3015, 3640], 'enhanced': [3040], 'contrast,': [3050, 3691, 3972], 'prelabeled': [3053], 'failed': [3055, 3378], 'exhibit': [3057], 'GTPγS-sensitive': [3058, 3116], 'formation': [3060, 3459, 3523], 'B).': [3068, 3850, 5183], 'oleate': [3070], 'some': [3079], 'effects': [3096, 5030, 5670, 5711], 'tested': [3098, 3996, 4123, 5248], '[3H]dipalmitoyl-PC,': [3104], 'no': [3106, 3226, 3417, 3472], 'shown).': [3112, 3484, 3514, 3599, 3945, 3970, 3991, 4046], 'To': [3113, 3249, 3347, 4068, 5402], 'fractionated': [3123, 3263], 'chromatography.': [3126, 4989], 'peak': [3128, 3234, 3274, 3312, 4894], 'GTPγS-dependent': [3130, 3188, 3580, 4001, 4503, 4545, 4944, 4996], 'early': [3137], 'part': [3138], '2).': [3144], 'order': [3146, 4023, 5945], 'investigate': [3148, 4588], 'SMGs,': [3152], 'immunoblotted': [3157], 'anti-ARF,': [3159], 'anti-RhoA,': [3160], 'anti-CDC42Hs': [3162], 'antibodies.': [3163, 6013], 'As': [3164, 3784, 4807], 'Fig.': [3167, 3717, 4411, 5698, 5702], '2,': [3168], 'these': [3169, 3961, 4014, 4455, 4812, 5322, 5348, 5370, 5378, 5545], 'SMGs': [3170, 4015, 4041, 4862, 4901, 5546, 5969], 'activity.': [3178, 4445, 4505, 4885], 'immunoreactivity': [3181, 3985, 4873], 'corresponded': [3182, 3318], 'major': [3185], 'exhibiting': [3187], 'although': [3191, 4181, 5050, 5264, 5604], 'minor': [3195], 'component': [3196], '(fractions': [3200], '30-34)': [3201], 'coeluted': [3203], 'CDC42.': [3207, 3428], 'we': [3210, 3299, 3360, 3764, 4075, 4508, 4543, 4557, 4756, 5185, 5409], 'remaining': [3213, 3302], 'inactive': [3214], 'ARF-responsive': [3227, 3256, 3393, 5606, 5919], 'enzyme.': [3228, 3346, 5401], 'an': [3244, 3736, 5605], 'YM': [3246], 'membrane.': [3248], 'determine': [3250], 'molecular': [3252, 3321, 3333], 'size': [3253], 'lesser': [3273], 'contained': [3285], '3).': [3288, 3327], 'Assuming': [3289], 'may': [3293, 5952], 'ARF,': [3298, 4915, 5564], 'mass': [3322, 3334], '>150': [3324], 'kDa': [3325], 'nature': [3329], 'higher': [3332, 3687, 3723], 'determined,': [3338], 'assumed': [3342], 'aggregated': [3345], 'explore': [3349, 4070], 'role': [3351, 4072, 5406, 5867], 'chromatographed': [3362], 'this': [3375, 4182, 4852, 5051, 5389, 5705, 5715, 5729, 5951, 6021], 'totally': [3377], 'any': [3381], 'unless': [3385], 'reconstituted': [3386], '4).': [3391], 'late': [3399], 'phase': [3400], 'gradient.': [3404], 'Endogenous': [3405], 'restored': [3412, 4017, 4918, 5214], 'DEAE-Sephacel,': [3437], 'hereinafter': [3438], 'referred': [3439], 'fraction,': [3444], 'time': [3455, 3486], 'course': [3456, 3487], '40': [3468], 'min,': [3469, 4318], 'essentially': [3471], 'seen': [3475], 'nucleotide': [3481, 5444], 'similar': [3489, 3538, 5000, 5163], '(assayed': [3496], '[3H]PC),': [3499], 'except': [3500], 'latter': [3503], 'producing': [3518], 'half-maximal': [3519], 'either': [3525, 4920, 5456], 'less': [3530, 5745], 'than': [3531, 5548], 'μM': [3533], '5).': [3535], 'cytosol-depleted': [3543], '(26Cockcroft': [3551], 'fraction': [3586, 3696, 4462, 4566, 4853], 'linearly': [3588], 'proportional': [3589], 'up': [3593, 4570], 'μg': [3596, 4369], 'millimolar': [3601], 'Ca2+': [3602, 3705, 3724, 5025], 'cation': [3663], 'negligible': [3666], 'effect': [3668, 4177, 5752], 'PC,': [3676], 'inhibitory': [3679], 'concentrations': [3681, 3778, 4167, 4208, 4377], '6).': [3689], '2-fold': [3699], '(corresponding': [3706], '165': [3708], 'n': [3709], 'free': [3711], 'legend': [3715], '6),': [3718], 'lost': [3721], 'concentrations.': [3725], 'view': [3727], 'indicating': [3732], 'unidentified': [3737], 'SMG': [3740], 'utilized': [3765], 'examine': [3769], 'function': [3775], 'increasing': [3777, 4166], '7': [3782, 3849, 5182], 'earlier': [3786, 5780], '([3H]myristate-labeled': [3813], 'membranes)': [3814], 'significantly': [3821, 3927, 5294], 'micromolar': [3824], 'Rho-GDI.': [3825], '[3H]PC,': [3836], 'Rho-GDI': [3837, 3856, 5172], 'more': [3839, 5174], 'potent': [3840], 'efficacious': [3842], 'inhibiting': [3844], 'treatment': [3852, 5308], 'extract': [3861], 'post-translationally': [3862], '(35Leonard': [3866], 'Hart': [3868], 'M.J.': [3869], 'Platko': [3870], 'J.V.': [3871], 'Eva': [3872], 'Henzel': [3874], 'Evans': [3876], '22860-22868Abstract': [3885], '36Bouguski': [3892], 'M.S.': [3893], 'McCormick': [3894], '366:': [3898], '643-654Crossref': [3899], '(1751)': [3902], 'Rac2.': [3920], 'Rac2,': [3934, 3950], 'extracts': [3942], 'examined': [3955], 'unextracted': [3957, 4060, 4119, 4198], 'absent': [3967, 5932], 'GDI-extracted': [3993, 5260, 5290], 'restoration': [3999], 'reconstitution': [4005, 4159, 5204], 'Rac1.': [4011, 5210], 'All': [4012], 'efficacy': [4025], '>': [4027, 4029], '8).': [4032], 'none': [4038], 'effective': [4043, 4054], 'Interestingly,': [4047], 'dose-dependent': [4057], 'manner': [4058, 4108], 'ineffective': [4065], '9).': [4067], 'studied': [4077, 4435, 5411], 'translocation': [4079, 4270, 5413], 'GTPγS.': [4091, 5713], 'translocated': [4104, 5439, 5942], 'time-dependent': [4107, 5447], '10).': [4115, 5430], 'sARF,': [4126], '11),': [4133], 'expected': [4135], 'marked': [4185, 5175], '11).FIG.': [4187], '9Effect': [4188], '(30': [4202, 4219, 4368, 4397], 'μg)': [4203], 'preincubated': [4205, 4373], 'indicated': [4207, 4305, 4376], 'μM)': [4220, 4300, 4398], 'ice': [4222, 4400], 'incubations': [4227], 'continued': [4229, 4407], 'ethanol.': [4240], '[3H]palmitoyl-PC': [4243], 'quantitated': [4245], 'under': [4248, 4346], '"Experimental': [4249, 4347], 'Procedures."': [4250], 'representative': [4252, 4415], 'experiment': [4253, 4405], 'duplicate': [4258], 'shown.View': [4260], 'Large': [4261, 4349, 4419], 'Image': [4262, 4350, 4420], 'Figure': [4263, 4351, 4421], 'ViewerDownload': [4264, 4352, 4422], 'Hi-res': [4265, 4353, 4423], 'image': [4266, 4354, 4424], 'Download': [4267, 4355, 4425], '(PPT)FIG.': [4268, 4356], '10GTPγS-dependent': [4269], '(0.1': [4280], 'mg)': [4281, 4285], '(0.05': [4284], 'buffer,': [4291], 'times.': [4306], 'pellets': [4320], 'Pellets': [4327], 'Laemmli': [4331], 'SDS': [4332], 'sample': [4333], 'subjected': [4336], 'Procedures."View': [4348], '11Effect': [4357], 'stimulation.': [4365], 'protein)': [4371], '10.': [4412], 'Data': [4413], 'are': [4414, 4429, 4602, 5060, 5077, 5554, 5691], 'experiments.View': [4418], '(PPT)': [4426], 'most': [4433], 'respect': [4439], 'It': [4446, 4938], 'generally': [4448], 'believed': [4449], 'located': [4458], 'particulate': [4461, 4554, 4565, 4596], 'guanine': [4468], 'nucleotides': [4469], 'mediated': [4471], 'factors.': [4474], 'One': [4475], 'factors': [4479], 'recently': [4481], 'ARF.': [4485, 4806, 5490], 'Like': [4486], 'findings,': [4488], 'our': [4489, 5774], 'indicate': [4497], 'requirement': [4499], 'surprisingly,': [4542], 'fraction.': [4555], 'Furthermore,': [4556, 5024, 5184], '5-fold': [4572], 'interesting': [4582, 4940], 'observations': [4583, 4601, 5775], 'provoked': [4584], 'us': [4585], 'fractions.': [4599], 'Our': [4600], 'consistent': [4603], 'finding': [4606], 'plus': [4624, 4766, 4769], 'requires': [4626], 'PIP2(25Brown': [4630], '37Massenburg': [4652], 'Han': [4654], 'J.-S.': [4655], 'Liyanage': [4656], 'Patton': [4658], 'W.A.': [4659], 'Rhee': [4660], 'S.G.': [4661], 'Proc.': [4666], 'Natl.': [4667], 'Acad.': [4668], 'U.': [4670], '91:': [4674], '11718-11722Crossref': [4675], '(245)': [4678], 'Also,': [4681], 'agreement': [4683], 'findings': [4686, 5461], '[3H]PC': [4781], 'evident': [4796], 'will': [4808, 5970], 'discussed': [4810], 'below,': [4811], 'explained': [4816, 5501], 'isoforms,': [4823], 'responsive': [4825], 'Rho.': [4831, 5530], 'use': [4833], 'made': [4838], 'possible': [4840, 5196, 5588], 'uncover': [4842], 'Chromatography': [4850], 'SMGs.': [4859, 5323, 5371], 'several': [4861], 'found,': [4864], 'initial': [4866], 'co-elution': [4867], 'supported': [4874], 'Further': [4886], 'chromatographic': [4905], 'procedures.': [4906], '(separated': [4923], 'column)': [4926], '(bovine': [4930], 'sARF).': [4931], 'note': [4942], 'liver': [4956], '2A.': [4958], 'Siddiqi,': [4960], 'L.': [4962], 'Smith,': [4963], 'Ross,': [4966], 'Qiu,': [4968], 'Symons,': [4970], 'Exton,': [4974], 'unpublished': [4975], 'results.': [4976, 5733], 'barely': [4979, 5022], 'measurable': [4980], 'crude': [4982], 'came': [4985], 'enriched': [4986], 'PLDs': [4994], 'dependence': [5001], 'nucleotide.': [5004], 'significant,': [5014], 'detectable.': [5023], 'ions': [5026], 'raise': [5038], 'possibility': [5040], 'subcellular': [5048], 'locations,': [5049], 'remains': [5052], 'speculative': [5053], 'until': [5054], 'enzymes': [5059], 'characterized.': [5063], '(which': [5076], 'all': [5078, 5247], 'cytosol),': [5082], 'members': [5091], 'CDC42)': [5099], '(Figs.': [5103], '9': [5104, 5271], '11).': [5106], 'Previously,': [5107], 'Bowman': [5108], 'GDI': [5142, 5307], 'We': [5161, 5341, 5975, 6014], 'inhibition': [5170], 'GDI,': [5193], 'restore': [5199, 5256, 5283], 'Bovine': [5211], 'probably': [5221], 'because': [5222], 'ARF-specific': [5230], 'isozymes.': [5232, 5579], 'Surprisingly,': [5233], 'did': [5241], 'much': [5244, 5972], 'specificity,': [5245], 'since': [5246, 5532, 5675, 5929], 'Rac1)': [5254], 'varying': [5266], 'extents.': [5267], '3Comparison': [5268], 'Figs.': [5270], 'shows': [5274, 5329], 'unable': [5280], 'completely': [5282], 'enhance': [5295], 'indicates': [5304], 'procedure': [5309], 'produced': [5310], 'additional': [5311], 'changes': [5312], 'diminished': [5314], 'ability': [5316], 'respond': [5320], 'Comparison': [5324], 'figures': [5327], 'relative': [5332], 'potency': [5333], 'changed.': [5340], 'do': [5342], 'know': [5344], 'reason': [5346], 'differences,': [5349], 'due': [5354], 'extraction': [5357], 'stimulator(s)': [5361], 'and/or': [5362], 'control': [5366, 5398, 5784], 'that,': [5376], 'proteins,': [5379], 'detectable': [5383, 5755], 'implying': [5387], 'member': [5394], 'exerted': [5396], 'emphasize': [5404], 'Among': [5431], 'manner.': [5448], 'Again,': [5449], 'support': [5462, 5776], 'Although,': [5473], 'synergistically': [5477], 'does': [5484], 'require': [5486, 5971], '4The': [5491], 'weak': [5492], 'interaction': [5494], 'between': [5495], 'responds': [5516, 5525, 5562], 'immediate': [5542], 'target': [5543], 'rather': [5547], 'regulatory': [5550], 'protein,': [5551], 'explanations': [5553], 'possible.': [5555], 'Contrary': [5556], 'Rho,': [5568], 'i.e.': [5569], 'must': [5571], 'makes': [5586], 'explain': [5590, 5731, 5748], 'versus': [5599], 'substrate.': [5601], 'example,': [5603], 'isozyme': [5607, 5706, 5716, 5909], 'cannot': [5665], 'responsible': [5667], 'alone': [5674], 'lacking': [5678], 'On': [5682], 'hand,': [5685], 'RhoA-responsive': [5687], '(cf.': [5697], '10),': [5703], 'therefore': [5708], 'mediate': [5709], 'If': [5714], 'able': [5718], 'utilize': [5720, 5743], '(under': [5723], 'specific': [5725, 5866], 'conditions)': [5727], 'efficiently,': [5728], 'efficiently': [5746], 'why': [5749], 'labeled.': [5771], 'summary,': [5773], 'investigations': [5781], 'provide': [5861], 'example': [5863], 'They': [5892], 'strongly': [5893], 'differ': [5901], 'location': [5904], 'regulation.': [5906], 'Rho-regulated': [5908], 'while': [5917], 'isolated': [5935], 'would': [5938], 'enzyme,': [5949], 'true': [5954], 'also.': [5957], 'Clearly,': [5958], 'elucidation': [5959], 'mechanisms': [5962], 'work.': [5974], 'thank': [5976, 6016], 'University)': [5983], 'Health)': [6005], 'generous': [6007], 'Childs': [6018], 'typing': [6020], 'manuscript.': [6022]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2079703085', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-07T16:26:36.825288', 'created_date': '2016-06-24'}
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