Publication Information

{'id': 'https://openalex.org/W2079605309', 'doi': 'https://doi.org/10.1074/jbc.m212829200', 'title': 'Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved', 'display_name': 'Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved', 'publication_year': 2003, 'publication_date': '2003-04-25', 'ids': {'openalex': 'https://openalex.org/W2079605309', 'doi': 'https://doi.org/10.1074/jbc.m212829200', 'mag': '2079605309', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12594207'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m212829200', 'pdf_url': 'http://www.jbc.org/article/S0021925819582370/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819582370/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5065085710', 'display_name': 'Nicolas W.J. Schröder', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140742', 'display_name': 'Institute of Medical Microbiology and Hygiene', 'ror': 'https://ror.org/04xqmb911', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210140742']}, {'id': 'https://openalex.org/I39343248', 'display_name': 'Humboldt-Universität zu Berlin', 'ror': 'https://ror.org/01hcx6992', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I39343248']}, {'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Nicolas W.J. Schröder', 'raw_affiliation_strings': ['Institut für Mikrobiologie und Hygiene, Universitätsklinikum “Charité,” Medizinische Fakultät der Humboldt-Universität zu Berlin, Dorotheenstrasse 96, D-10117 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Mikrobiologie und Hygiene, Universitätsklinikum “Charité,” Medizinische Fakultät der Humboldt-Universität zu Berlin, Dorotheenstrasse 96, D-10117 Berlin, Germany', 'institution_ids': ['https://openalex.org/I4210140742', 'https://openalex.org/I39343248', 'https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075087968', 'display_name': 'Siegfried Morath', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189712700', 'display_name': 'University of Konstanz', 'ror': 'https://ror.org/0546hnb39', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I189712700']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Siegfried Morath', 'raw_affiliation_strings': ['§Biochemische Pharmakologie, Universität Konstanz, Box M 668, D-78457 Konstanz, Germany'], 'affiliations': [{'raw_affiliation_string': '§Biochemische Pharmakologie, Universität Konstanz, Box M 668, D-78457 Konstanz, Germany', 'institution_ids': ['https://openalex.org/I189712700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109387205', 'display_name': 'Christian Alexander', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128097', 'display_name': 'Research Center Borstel - Leibniz Lung Center', 'ror': 'https://ror.org/036ragn25', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210128097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christian Alexander', 'raw_affiliation_strings': ['¶Abteilung Immunchemie und Medizinische Mikrobiologie, Forschungszentrum Borstel, Zentrum für Medizin und Biowissenschaften, Parkallee 22, D-23845 Borstel, Germany'], 'affiliations': [{'raw_affiliation_string': '¶Abteilung Immunchemie und Medizinische Mikrobiologie, Forschungszentrum Borstel, Zentrum für Medizin und Biowissenschaften, Parkallee 22, D-23845 Borstel, Germany', 'institution_ids': ['https://openalex.org/I4210128097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020269983', 'display_name': 'Lutz Hamann', 'orcid': 'https://orcid.org/0000-0003-4719-2583'}, 'institutions': [{'id': 'https://openalex.org/I39343248', 'display_name': 'Humboldt-Universität zu Berlin', 'ror': 'https://ror.org/01hcx6992', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I39343248']}, {'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}, {'id': 'https://openalex.org/I4210140742', 'display_name': 'Institute of Medical Microbiology and Hygiene', 'ror': 'https://ror.org/04xqmb911', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210140742']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lutz Hamann', 'raw_affiliation_strings': ['Institut für Mikrobiologie und Hygiene, Universitätsklinikum “Charité,” Medizinische Fakultät der Humboldt-Universität zu Berlin, Dorotheenstrasse 96, D-10117 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Mikrobiologie und Hygiene, Universitätsklinikum “Charité,” Medizinische Fakultät der Humboldt-Universität zu Berlin, Dorotheenstrasse 96, D-10117 Berlin, Germany', 'institution_ids': ['https://openalex.org/I39343248', 'https://openalex.org/I7877124', 'https://openalex.org/I4210140742']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091124551', 'display_name': 'Thomas Härtung', 'orcid': 'https://orcid.org/0000-0003-1359-7689'}, 'institutions': [{'id': 'https://openalex.org/I189712700', 'display_name': 'University of Konstanz', 'ror': 'https://ror.org/0546hnb39', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I189712700']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Hartung', 'raw_affiliation_strings': ['§Biochemische Pharmakologie, Universität Konstanz, Box M 668, D-78457 Konstanz, Germany'], 'affiliations': [{'raw_affiliation_string': '§Biochemische Pharmakologie, Universität Konstanz, Box M 668, D-78457 Konstanz, Germany', 'institution_ids': ['https://openalex.org/I189712700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090327349', 'display_name': 'Ulrich Zähringer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128097', 'display_name': 'Research Center Borstel - Leibniz Lung Center', 'ror': 'https://ror.org/036ragn25', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210128097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ulrich Zähringer', 'raw_affiliation_strings': ['¶Abteilung Immunchemie und Medizinische Mikrobiologie, Forschungszentrum Borstel, Zentrum für Medizin und Biowissenschaften, Parkallee 22, D-23845 Borstel, Germany'], 'affiliations': [{'raw_affiliation_string': '¶Abteilung Immunchemie und Medizinische Mikrobiologie, Forschungszentrum Borstel, Zentrum für Medizin und Biowissenschaften, Parkallee 22, D-23845 Borstel, Germany', 'institution_ids': ['https://openalex.org/I4210128097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109964426', 'display_name': 'Ulf B. Göbel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39343248', 'display_name': 'Humboldt-Universität zu Berlin', 'ror': 'https://ror.org/01hcx6992', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I39343248']}, {'id': 'https://openalex.org/I4210140742', 'display_name': 'Institute of Medical Microbiology and Hygiene', 'ror': 'https://ror.org/04xqmb911', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210140742']}, {'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ulf B. Göbel', 'raw_affiliation_strings': ['Institut für Mikrobiologie und Hygiene, Universitätsklinikum “Charité,” Medizinische Fakultät der Humboldt-Universität zu Berlin, Dorotheenstrasse 96, D-10117 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Mikrobiologie und Hygiene, Universitätsklinikum “Charité,” Medizinische Fakultät der Humboldt-Universität zu Berlin, Dorotheenstrasse 96, D-10117 Berlin, Germany', 'institution_ids': ['https://openalex.org/I39343248', 'https://openalex.org/I4210140742', 'https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103562756', 'display_name': 'Joerg R. Weber', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39343248', 'display_name': 'Humboldt-Universität zu Berlin', 'ror': 'https://ror.org/01hcx6992', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I39343248']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Joerg R. Weber', 'raw_affiliation_strings': ['‖Neurologische Klinik, Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin, Schumannstr. 20/21, D-10098 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': '‖Neurologische Klinik, Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin, Schumannstr. 20/21, D-10098 Berlin, Germany', 'institution_ids': ['https://openalex.org/I39343248']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110435290', 'display_name': 'Ralf R. Schumann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140742', 'display_name': 'Institute of Medical Microbiology and Hygiene', 'ror': 'https://ror.org/04xqmb911', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210140742']}, {'id': 'https://openalex.org/I39343248', 'display_name': 'Humboldt-Universität zu Berlin', 'ror': 'https://ror.org/01hcx6992', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I39343248']}, {'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ralf R. Schumann', 'raw_affiliation_strings': ['Institut für Mikrobiologie und Hygiene, Universitätsklinikum “Charité,” Medizinische Fakultät der Humboldt-Universität zu Berlin, Dorotheenstrasse 96, D-10117 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Mikrobiologie und Hygiene, Universitätsklinikum “Charité,” Medizinische Fakultät der Humboldt-Universität zu Berlin, Dorotheenstrasse 96, D-10117 Berlin, Germany', 'institution_ids': ['https://openalex.org/I4210140742', 'https://openalex.org/I39343248', 'https://openalex.org/I7877124']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 11.473, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 639, 'citation_normalized_percentile': {'value': 0.999875, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '278', 'issue': '18', 'first_page': '15587', 'last_page': '15594'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10654', 'display_name': 'Pneumonia and Respiratory Infections', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Antibiotics Pharmacokinetics and Efficacy', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lipoteichoic-acid', 'display_name': 'Lipoteichoic acid', 'score': 0.9701574}, {'id': 'https://openalex.org/keywords/lipopolysaccharide-binding-protein', 'display_name': 'Lipopolysaccharide binding protein', 'score': 0.4916194}], 'concepts': [{'id': 'https://openalex.org/C6977687', 'wikidata': 'https://www.wikidata.org/wiki/Q781350', 'display_name': 'Lipoteichoic acid', 'level': 4, 'score': 0.9701574}, {'id': 'https://openalex.org/C2778513237', 'wikidata': 'https://www.wikidata.org/wiki/Q419553', 'display_name': 'CD14', 'level': 3, 'score': 0.6528603}, {'id': 'https://openalex.org/C2776709828', 'wikidata': 'https://www.wikidata.org/wiki/Q408004', 'display_name': 'Toll-like receptor', 'level': 4, 'score': 0.6140654}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.56198215}, {'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.55537045}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.51320744}, {'id': 'https://openalex.org/C2776822972', 'wikidata': 'https://www.wikidata.org/wiki/Q14907577', 'display_name': 'Lipopolysaccharide binding protein', 'level': 4, 'score': 0.4916194}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.42769805}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.35793588}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35441148}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34124908}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.24445039}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.08949357}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000209', 'descriptor_name': 'Acute-Phase Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000954', 'descriptor_name': 'Antigens, Surface', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018950', 'descriptor_name': 'Lipopolysaccharide Receptors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009000', 'descriptor_name': 'Monocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013211', 'descriptor_name': 'Staphylococcus aureus', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D013682', 'descriptor_name': 'Teichoic Acids', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000954', 'descriptor_name': 'Antigens, Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018950', 'descriptor_name': 'Lipopolysaccharide Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051218', 'descriptor_name': 'Lymphocyte Antigen 96', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009000', 'descriptor_name': 'Monocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009000', 'descriptor_name': 'Monocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013211', 'descriptor_name': 'Staphylococcus aureus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013682', 'descriptor_name': 'Teichoic Acids', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D013682', 'descriptor_name': 'Teichoic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051195', 'descriptor_name': 'Toll-Like Receptor 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051197', 'descriptor_name': 'Toll-Like Receptor 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051193', 'descriptor_name': 'Toll-Like Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m212829200', 'pdf_url': 'http://www.jbc.org/article/S0021925819582370/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12594207', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m212829200', 'pdf_url': 'http://www.jbc.org/article/S0021925819582370/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.4}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W148231546', 'https://openalex.org/W1484908957', 'https://openalex.org/W1487188207', 'https://openalex.org/W1501761310', 'https://openalex.org/W1601451310', 'https://openalex.org/W1766658148', 'https://openalex.org/W1775363067', 'https://openalex.org/W1797516342', 'https://openalex.org/W1871414536', 'https://openalex.org/W1894549605', 'https://openalex.org/W1925363657', 'https://openalex.org/W1965148084', 'https://openalex.org/W1967628584', 'https://openalex.org/W1968134126', 'https://openalex.org/W1968293504', 'https://openalex.org/W1976424894', 'https://openalex.org/W1976467135', 'https://openalex.org/W1985782125', 'https://openalex.org/W2001822032', 'https://openalex.org/W2008152503', 'https://openalex.org/W2010216317', 'https://openalex.org/W2010960519', 'https://openalex.org/W2013472315', 'https://openalex.org/W2021551123', 'https://openalex.org/W2024694630', 'https://openalex.org/W2029157767', 'https://openalex.org/W2040230044', 'https://openalex.org/W2040642611', 'https://openalex.org/W2064435741', 'https://openalex.org/W2064626913', 'https://openalex.org/W2067294390', 'https://openalex.org/W2071196984', 'https://openalex.org/W2073352481', 'https://openalex.org/W2076322521', 'https://openalex.org/W2078004260', 'https://openalex.org/W2079237776', 'https://openalex.org/W2087867048', 'https://openalex.org/W2088703955', 'https://openalex.org/W2094747692', 'https://openalex.org/W2095718564', 'https://openalex.org/W2095833996', 'https://openalex.org/W2100837269', 'https://openalex.org/W2101834325', 'https://openalex.org/W2102439761', 'https://openalex.org/W2102552341', 'https://openalex.org/W2107988027', 'https://openalex.org/W2114132866', 'https://openalex.org/W2114243917', 'https://openalex.org/W2117888940', 'https://openalex.org/W2121105123', 'https://openalex.org/W2121563852', 'https://openalex.org/W2130938511', 'https://openalex.org/W2132177571', 'https://openalex.org/W2133218406', 'https://openalex.org/W2133449490', 'https://openalex.org/W2135536286', 'https://openalex.org/W2138067578', 'https://openalex.org/W2138852428', 'https://openalex.org/W2140076442', 'https://openalex.org/W2141067630', 'https://openalex.org/W2144828448', 'https://openalex.org/W2159647500', 'https://openalex.org/W2161551296', 'https://openalex.org/W2167059596', 'https://openalex.org/W2168452238', 'https://openalex.org/W2312285345', 'https://openalex.org/W2333245418', 'https://openalex.org/W4236273750'], 'related_works': ['https://openalex.org/W3032799854', 'https://openalex.org/W2392062866', 'https://openalex.org/W2365342469', 'https://openalex.org/W2161371459', 'https://openalex.org/W2114057099', 'https://openalex.org/W2079605309', 'https://openalex.org/W2060806106', 'https://openalex.org/W2052637669', 'https://openalex.org/W2033813366', 'https://openalex.org/W2010682360'], 'abstract_inverted_index': {'Lipoteichoic': [0, 172], 'acid': [1, 173, 348, 1390, 2768], '(LTA)': [2, 174, 1391], 'derived': [3, 175, 359, 365, 2297, 3399, 4112], 'fromStreptococcus': [4, 176], 'pneumoniae,': [5, 177, 714], 'purified': [6, 178, 2668, 2992, 4095], 'employing': [7, 179, 2638, 2791, 3355, 3680, 3890, 4001, 4256], 'a': [8, 180, 911, 1074, 1087, 1132, 1135, 1175, 1227, 1482, 1609, 1674, 1926, 1984, 1995, 2038, 2083, 2089, 2094, 2178, 2247, 2315, 2639, 2865, 2907, 2931, 3001, 3061, 3074, 3083, 3139, 3171, 3324, 3356, 3451, 3771, 3837, 3931, 4116, 4136, 4168, 4194, 4277], 'chloroform/methanol': [9, 181, 2640, 4093], 'protocol,': [10, 182, 2759], 'and': [11, 37, 39, 55, 57, 65, 92, 132, 164, 183, 209, 211, 227, 229, 237, 264, 304, 336, 478, 496, 615, 710, 734, 868, 952, 990, 1015, 1057, 1162, 1180, 1183, 1236, 1243, 1320, 1388, 1412, 1499, 1608, 1685, 2026, 2093, 2174, 2217, 2260, 2301, 2317, 2429, 2447, 2474, 2497, 2509, 2522, 2604, 2615, 2627, 2664, 2701, 2710, 2719, 2724, 2823, 2859, 2896, 2922, 2967, 3099, 3149, 3183, 3194, 3214, 3232, 3253, 3295, 3395, 3410, 3513, 3527, 3535, 3555, 3601, 3647, 3671, 3742, 3763, 3765, 3820, 3860, 3876, 3899, 3903, 3918, 3922, 3987, 4083, 4094, 4106, 4147, 4182, 4272, 4300, 4333, 4343], 'from': [12, 42, 184, 214, 1990, 2017, 2130, 2298, 2454, 2634, 2868, 2994, 3205, 3400, 4032, 4113], 'Staphylococcus': [13, 185, 532], 'aureus,': [14, 186, 533, 682, 2168, 2356], 'prepared': [15, 187, 2533], 'by': [16, 77, 81, 118, 152, 188, 249, 253, 290, 324, 419, 626, 864, 892, 907, 1029, 1083, 1170, 1241, 1267, 1935, 2020, 2047, 2266, 2354, 2422, 2480, 2502, 2534, 2538, 2585, 2606, 2618, 2624, 2669, 2831, 2938, 2952, 3115, 3158, 3267, 3306, 3405, 3468, 3564, 3586, 3692, 3728, 3916, 4015, 4022, 4230, 4238, 4254, 4296, 4414], 'the': [17, 139, 145, 153, 160, 189, 311, 317, 325, 332, 411, 420, 462, 465, 487, 493, 538, 546, 597, 608, 619, 650, 731, 754, 763, 886, 916, 946, 1032, 1077, 1084, 1146, 1234, 1316, 1361, 1369, 1383, 1400, 1404, 1408, 1489, 1493, 1670, 1680, 1816, 2140, 2144, 2149, 2169, 2239, 2344, 2359, 2416, 2438, 2450, 2458, 2470, 2491, 2675, 2722, 2746, 2757, 2792, 2801, 2899, 2939, 2953, 2986, 3029, 3153, 3166, 3201, 3328, 3672, 3722, 3877, 4002, 4007, 4081, 4084, 4088, 4128, 4160, 4172, 4180, 4187, 4201, 4223, 4239, 4246, 4266, 4284, 4338], 'recently': [18, 190], 'described': [19, 191, 1416, 1615, 1983, 2079, 2544, 2643, 2673], 'butanol': [20, 192, 1996, 2535], 'extraction': [21, 193, 1997, 2536], 'procedure,': [22, 194], 'was': [23, 53, 79, 169, 195, 225, 251, 341, 2031, 2290, 2467, 2490, 2532, 2595, 2632, 2726, 2789, 2888, 2920, 2983, 2998, 3058, 3078, 3106, 3110, 3136, 3156, 3197, 3208, 3246, 3346, 3391, 3553, 3578, 3726, 3740, 3751, 3888], 'investigated': [24, 196], 'regarding': [25, 197], 'its': [26, 198, 766], 'interaction': [27, 199, 2451, 3069], 'with': [28, 63, 105, 109, 200, 235, 277, 281, 642, 647, 762, 1312, 1368, 1611, 2052, 2343, 2358, 2457, 2715, 2898, 3072, 3129, 3165, 3210, 3310, 3374, 3393, 3459, 3487, 3506, 3566, 3581, 3605, 3624, 3655, 3784, 3825, 3855, 3862, 3901, 4092, 4122, 4156, 4259, 4291, 4320, 4408], 'lipopolysaccharide': [29, 201, 344, 771], '(LPS)-binding': [30, 202], 'protein': [31, 203, 346, 909, 913, 4163], '(LBP),': [32, 204, 910], 'CD14,': [33, 131, 205, 303, 2443, 3985], 'Toll-like': [34, 206, 1128], 'receptors': [35, 207, 1138], '(TLRs)-2': [36, 208], '-4,': [38, 210], 'MD-2.': [40, 212], 'LTA': [41, 62, 74, 101, 128, 213, 234, 246, 273, 300, 358, 364, 1480, 1788, 1830, 1989, 2016, 2055, 2078, 2129, 2212, 2243, 2423, 2453, 2481, 2525, 2630, 2676, 2711, 3004, 3904, 4029, 4040, 4111, 4213, 4255, 4297, 4304, 4332], 'both': [43, 215, 2520], 'organisms': [44, 216], 'induced': [45, 217, 4274, 4295], 'cytokine': [46, 218, 1265, 1571, 1619, 2477, 4293, 4412], 'synthesis': [47, 219], 'in': [48, 138, 144, 166, 220, 310, 316, 338, 396, 492, 537, 543, 558, 618, 635, 637, 726, 730, 915, 988, 1013, 1141, 1167, 1269, 1399, 1496, 1573, 1617, 1687, 1824, 2037, 2139, 2211, 2310, 2314, 2449, 2476, 2499, 2513, 2597, 2765, 2811, 2841, 2891, 2915, 3018, 3028, 3217, 3250, 3285, 3297, 3313, 3323, 3327, 3407, 3494, 3591, 3610, 3746, 3753, 3812, 3844, 3906, 3935, 3973, 4150, 4200, 4265, 4276, 4283, 4337, 4350], 'human': [49, 221, 385, 2039, 3037, 3052, 3290, 3332, 3337, 3606, 3785, 4251, 4344, 4406], 'mononuclear': [50, 222, 355, 1574, 4252], 'phagocytes.': [51, 223], 'Activation': [52, 224], 'LBP-': [54, 226], 'CD14-dependent,': [56, 228], 'formation': [58, 230], 'of': [59, 61, 73, 115, 127, 141, 147, 162, 231, 233, 245, 287, 299, 313, 319, 334, 414, 468, 489, 611, 652, 676, 756, 765, 888, 896, 948, 955, 1031, 1065, 1079, 1086, 1134, 1137, 1174, 1178, 1238, 1318, 1324, 1364, 1382, 1407, 1484, 1492, 1672, 1676, 1682, 1796, 1818, 1826, 1929, 1938, 2028, 2088, 2143, 2148, 2242, 2253, 2306, 2364, 2441, 2452, 2464, 2472, 2482, 2494, 2516, 2526, 2613, 2677, 2959, 2971, 2979, 3010, 3033, 3063, 3068, 3070, 3076, 3086, 3118, 3121, 3142, 3147, 3168, 3174, 3192, 3330, 3351, 3415, 3464, 3575, 3732, 3839, 3909, 3920, 3983, 3994, 4011, 4020, 4039, 4087, 4127, 4132, 4145, 4162, 4174, 4186, 4196, 4215, 4250, 4268, 4311, 4316, 4326, 4331, 4340, 4405], 'complexes': [60, 232], 'LBP': [64, 78, 236, 250, 943, 2473, 2508, 2972, 3053, 3071, 3081, 3150, 3338, 3344], 'soluble': [66, 238, 362, 953, 2964], 'CD14': [67, 76, 239, 248, 363, 956, 2475, 2510, 2965, 3607, 3786], 'as': [68, 70, 240, 242, 405, 898, 900, 1226, 1792, 2435, 2543, 2642, 2672, 2950, 3000, 3450, 3989, 3991, 4190, 4192], 'well': [69, 241, 899, 3646, 3990, 4191], 'catalytic': [71, 243], 'transfer': [72, 244, 947, 2812], 'to': [75, 100, 247, 272, 400, 596, 649, 950, 1062, 1072, 1145, 1186, 1233, 1271, 1315, 1395, 1417, 1488, 2033, 2080, 2137, 2177, 2208, 2263, 2352, 2389, 2468, 2519, 2600, 2729, 2756, 2770, 2825, 2963, 2968, 3124, 3162, 3170, 3200, 3315, 3348, 3382, 3412, 3478, 3630, 3635, 4154, 4306, 4313, 4322], 'verified': [80, 252, 3157], 'PhastGelTM': [82, 254, 3125, 3130, 3184], 'native': [83, 255, 3101, 3131, 3160, 3193], 'gel': [84, 256, 2981], 'electrophoresis.': [85, 257, 3186], 'Human': [86, 258], 'embryonic': [87, 259, 386], 'kidney': [88, 260, 387], '(HEK)': [89, 261], '293/CD14': [90, 262], 'cells': [91, 97, 117, 263, 269, 289, 903, 1030, 1061, 1420, 2313, 2637, 3282, 3371, 3456, 3600, 3602, 3632, 3644, 3652, 3743, 3781, 3833, 3929, 4346], 'Chinese': [93, 265, 382], 'hamster': [94, 266], 'ovary': [95, 267, 384], '(CHO)': [96, 268], 'were': [98, 270, 1832, 2045, 2385, 2622, 2667, 2705, 2713, 2743, 2763, 2809, 2839, 2936, 3016, 3095, 3223, 3265, 3283, 3321, 3372, 3457, 3476, 3485, 3533, 3608, 3621, 3633, 3653, 3689, 3744, 3761, 3768, 3810, 3822, 3834, 3853, 3897, 3971, 3998, 4235, 4298], 'responsive': [99, 271], 'only': [102, 274, 1924], 'after': [103, 275], 'transfection': [104, 108, 276, 280, 3684, 3861], 'TLR-2.': [106, 278], 'Additional': [107, 279], 'MD-2': [110, 165, 282, 337, 1282, 1686, 2448, 2498, 3933], 'did': [111, 283], 'not': [112, 284, 1923], 'affect': [113, 285], 'stimulation': [114, 286, 1247, 3383, 3831, 4257], 'these': [116, 288, 723, 1827], 'LTA.': [119, 291, 2503, 2524, 4415], 'Our': [120, 292, 2504], 'data': [121, 293, 2050, 2505], 'suggest': [122, 294], 'that': [123, 295, 483, 2257, 2292, 2346, 2507, 2761], 'innate': [124, 296, 421, 1168, 1370, 2459], 'immune': [125, 297, 422, 1371, 1419, 2362, 2460, 2517], 'recognition': [126, 298], 'via': [129, 301, 1274], 'LBP,': [130, 302, 2442, 3984], 'TLR-2': [133, 305, 2316, 2444], 'represents': [134, 306, 1481], 'an': [135, 307, 555, 856, 1164, 1277, 1793, 2976, 3592], 'important': [136, 156, 308, 328, 556, 1165, 1794], 'mechanism': [137, 309], 'pathogenesis': [140, 312, 755], 'systemic': [142, 314, 402, 490, 889], 'complications': [143, 315, 403], 'course': [146, 318, 887], 'infectious': [148, 320], 'diseases': [149, 321], 'brought': [150, 322], 'about': [151, 323, 631], 'clinically': [154, 326], 'most': [155, 327, 548, 1825, 4210], 'Gram-positive': [157, 329, 469, 484, 1365, 1497, 2132], 'pathogens.': [158, 330], 'However,': [159, 331, 1067, 1786, 2128, 2415], 'involvement': [161, 333, 1681, 2493], 'TLR-4': [163, 335, 1222, 1319, 1325, 3988], 'this': [167, 339, 2021, 2465], 'process': [168, 340], 'ruled': [170, 342], 'out.': [171, 343], 'LPS-binding': [345, 908], 'lipoteichoic': [347, 1389], 'muramyldipeptide': [349, 3460, 4409], 'nuclear': [350], 'factor': [351, 372, 2308], 'κB': [352], 'peripheral': [353, 4261], 'blood': [354, 2041, 4262], 'cell': [356, 869, 1384, 1410, 1504, 1689, 2295], 'peptidoglycan': [357, 1386, 4334], 'fromS.': [360, 366, 2244, 2424], 'pneumoniae': [361, 542, 603, 2245, 2303, 2456, 2484, 2564], 'aureus': [367, 1992, 2300, 2425, 2528, 2679], 'toll-like': [368], 'receptor': [369, 1129, 1148, 1229], 'tumor': [370], 'necrosis': [371], 'α': [373], 'phosphate-buffered': [374, 2842, 3020], 'saline': [375, 2843, 3021], 'enzyme-linked': [376], 'immunosorbent': [377], 'assay': [378], 'fetal': [379, 3515], 'calf': [380, 3516], 'serum': [381, 912, 2848, 2894, 2918, 3333, 3517], 'Hamster': [383], "Dulbecco's": [388, 3019, 3611], 'modified': [389, 3612], "Eagle's": [390, 3613], 'medium': [391, 2599, 3614, 3739, 3815, 3857, 3911, 3975], 'antibody': [392, 2911, 3376, 3545], 'Invasive': [393], 'bacterial': [394, 902, 1409, 2620, 2636], 'infections': [395, 474, 491, 560, 624, 890, 1188], 'mammals': [397], 'may': [398], 'lead': [399], 'severe': [401], 'such': [404], 'septic': [406, 757], 'shock,': [407], 'once': [408], 'bacteria': [409, 470, 753, 865, 1179, 1366, 1498, 2614], 'overcome': [410], 'first': [412], 'line': [413], 'defense,': [415], 'which': [416, 1310, 1922, 3725], 'is': [417, 545, 607, 861, 1026, 1131, 1283, 1373, 1500, 1789, 1820, 2341], 'mediated': [418], 'system': [423, 1372, 2941], '(1Medzhitov': [424], 'R.': [425, 658, 1099, 1210, 1286, 1440, 1463, 1519, 1536, 1593, 1597, 1648, 1725, 1745, 1747, 1881, 1885, 1897, 1899, 2329, 2403, 4380], 'Janeway': [426], 'Jr.,': [427, 1207], 'C.A.': [428, 1208], 'Cell.': [429], '1997;': [430], '91:': [431], '295-298Abstract': [432], 'Full': [433, 435, 1470, 1472, 1760, 1762, 1806, 1808, 1912, 1914, 2577, 3439, 3441], 'Text': [434, 436, 1471, 1473, 1761, 1763, 1807, 1809, 1913, 1915, 2578, 3440, 3442], 'PDF': [437, 1474, 1764, 1810, 1916, 2579, 3443], 'PubMed': [438, 456, 512, 575, 667, 705, 746, 784, 882, 938, 970, 1052, 1123, 1157, 1202, 1217, 1260, 1305, 1351, 1436, 1451, 1475, 1524, 1541, 1566, 1589, 1605, 1640, 1664, 1719, 1739, 1765, 1781, 1811, 1859, 1877, 1893, 1917, 1955, 1975, 2011, 2072, 2109, 2125, 2163, 2196, 2232, 2283, 2337, 2378, 2410, 2558, 2580, 2659, 2692, 2737, 2781, 2883, 3444, 3716, 3805, 3966, 4055, 4074, 4372, 4396], 'Scopus': [439, 457, 668, 706, 747, 785, 939, 971, 1053, 1124, 1158, 1203, 1218, 1306, 1352, 1452, 1476, 1542, 1641, 1665, 1720, 1740, 1766, 1782, 1812, 1860, 1918, 1956, 1976, 2012, 2073, 2110, 2197, 2233, 2284, 2379, 2411, 2559, 2660, 2693, 2738, 2782, 2884, 3445, 3717, 3806, 3967, 4056, 4075, 4373, 4397], '(1985)': [440], 'Google': [441, 459, 513, 530, 576, 593, 670, 708, 749, 787, 841, 853, 883, 941, 973, 1055, 1107, 1126, 1160, 1205, 1220, 1261, 1308, 1354, 1437, 1454, 1478, 1525, 1544, 1567, 1590, 1606, 1643, 1667, 1722, 1742, 1768, 1784, 1814, 1862, 1878, 1894, 1920, 1958, 1978, 2014, 2075, 2112, 2126, 2164, 2199, 2235, 2286, 2338, 2381, 2413, 2561, 2581, 2662, 2695, 2740, 2784, 2886, 3447, 3719, 3808, 3969, 4058, 4077, 4375, 4399], 'Scholar,': [442, 514, 577, 788, 842, 974, 998, 1108, 1438, 1455, 1526, 1545, 1591, 1644, 1723, 1743, 1769, 1863, 1879, 1895, 1959, 2113, 4059, 4376], '2Munford': [443], 'R.S.': [444, 978], 'Pugin': [445], 'J.': [446, 448, 520, 522, 583, 585, 699, 779, 816, 847, 1102, 1254, 1299, 1445, 1464, 1734, 1754, 1776, 1906, 2005, 2066, 2274, 2278, 2332, 2373, 2404, 2552, 2571, 2650, 2654, 2686, 2874, 2878, 3433, 3694, 3710, 3800, 3960, 4046, 4050], 'Am.': [447], 'Respir.': [449], 'Crit.': [450], 'Care': [451], 'Med.': [452, 1301, 2007, 2068, 2102, 2554, 2688, 3712, 3962], '2001;': [453, 527, 590, 850, 1257, 1661, 1736, 1952, 2008, 2555, 2689, 3436, 3963, 4393], '163:': [454, 2335], '316-321Crossref': [455], '(456)': [458], 'Scholar).': [460, 531, 594, 671, 750, 854, 884, 942, 1023, 1127, 1221, 1262, 1355, 1479, 1568, 1668, 1785, 1979, 2015, 2076, 2127, 2165, 2200, 2236, 2287, 2339, 2382, 2414, 2562, 2696, 2741, 2785, 4078], 'During': [461, 672], 'last': [463], 'decade,': [464], 'relative': [466], 'number': [467, 651, 1675], 'responsible': [471, 629], 'for': [472, 599, 630, 722, 1076, 1230, 1988, 2674, 2853, 2924, 3045, 3180, 3241, 3261, 3278, 3302, 3387, 3520, 3560, 3571, 3658, 3757, 3866, 3885, 3912, 4027, 4037, 4179, 4193], 'bloodstream': [473], 'has': [475, 716, 759, 1069, 1223, 1413, 1613, 2204, 2426, 2432], 'steadily': [476], 'increased,': [477], 'recent': [479, 673], 'epidemiological': [480], 'studies': [481, 1379, 1828, 3409, 4352], 'revealed': [482], 'microorganisms': [485], 'cause': [486, 610], 'majority': [488], 'United': [494, 539, 620, 732], 'States': [495, 540, 733], 'Europe': [497], '(3Pfaller': [498, 561], 'M.A.': [499, 562, 687], 'Jones': [500, 563, 688], 'R.N.': [501, 564, 689], 'Doern': [502, 565, 690], 'G.V.': [503, 566, 691], 'Kugler': [504, 567, 692], 'K.': [505, 568, 808, 1294, 1296, 1345, 1530, 1713, 1729, 1773, 1853, 2370, 2395, 3729, 3957], 'Antimicrob.': [506, 569, 700, 1560], 'Agents': [507, 570, 1561], 'Chemother.': [508, 571, 1562], '1998;': [509, 572, 1563, 3713], '42:': [510, 573, 1564], '1762-1770Crossref': [511, 574], '4Fluit': [515, 578], 'A.C.': [516, 579], 'Schmitz': [517, 580], 'F.J.': [518, 581, 1152], 'Verhoef': [519, 582], 'Eur.': [521, 584, 2277, 2653, 2877, 3799, 4049], 'Clin.': [523, 586], 'Microbiol.': [524, 587, 836, 2103], 'Infect.': [525, 588, 741, 877, 1431, 1446, 1584, 1600, 1659, 1801, 1872, 1888, 1950, 1970, 2120, 2158, 2405, 4391], 'Dis.': [526, 589, 742, 1447, 1802, 2406], '20:': [528, 591, 1215], '188-191PubMed': [529, 592], 'followed': [534, 2537, 3305, 3563, 3585, 3915], 'byEnterococcus': [535], 'spp.': [536, 644], 'andStreptococcus': [541], 'Europe,': [544], 'organism': [547], 'frequently': [549], 'isolated': [550, 4260], 'during': [551, 866, 1503, 3152], 'invasive': [552, 623], 'infections,': [553, 724], 'playing': [554, 1163], 'role': [557, 1166, 2471], 'hospital': [559], 'According': [595], 'Centers': [598], 'Disease': [600], 'Control,': [601], 'S.': [602, 681, 713, 798, 824, 831, 1093, 1288, 1329, 1337, 1577, 1599, 1635, 1646, 1650, 1654, 1656, 1697, 1705, 1775, 1837, 1845, 1865, 1887, 1961, 1991, 2000, 2018, 2057, 2167, 2299, 2302, 2355, 2372, 2455, 2483, 2527, 2547, 2563, 2678, 2681, 3428, 4069, 4367, 4378, 4382, 4386, 4388], '(also': [604], 'called': [605], 'pneumococcus)': [606], 'major': [609, 718, 767, 4143], 'community-acquired': [612], 'pneumonia,': [613], 'meningitis,': [614], 'otitis': [616], 'media': [617], 'States.': [621], 'Furthermore,': [622], 'caused': [625, 891, 1082, 2479], 'pneumococci': [627, 711], 'are': [628, 904, 1933, 2261, 2349, 2511, 4013], 'one': [632, 4016], 'million': [633], 'deaths': [634], 'children': [636], 'developing': [638], 'countries': [639], 'yearly,': [640], 'comparable': [641, 4324], 'Plasmodium': [643], 'causing': [645], 'malaria,': [646], 'respect': [648], 'incidents': [653], '(5Greenwood': [654], 'B.': [655, 661, 1249], 'Philos.': [656], 'Trans.': [657], 'Soc.': [659], 'Lond.': [660], 'Biol.': [662, 1465, 1755, 1907, 2192, 2228, 2572, 3434], 'Sci.': [663, 1633, 4067, 4365], '1999;': [664, 1302, 1467, 1521, 1757, 1909, 2334], '354:': [665], '777-785Crossref': [666, 1450], '(149)': [669], 'years,': [674], 'spreading': [675], 'multiresistant': [677], 'staphylococci': [678, 4114], '(i.e.': [679], 'methicillin-resistant': [680], 'MRSA,': [683], 'Ref.6Diekema': [684], 'D.J.': [685], 'Pfaller': [686], 'K.C.': [693], 'Beach': [694], 'M.L.': [695], 'Sader': [696], 'H.S.': [697], 'Int.': [698], 'Agents.': [701], '2000;': [702, 967, 1199, 1538, 1778, 2375, 3802], '13:': [703], '257-271Crossref': [704], '(129)': [707], 'Scholar)': [709, 1056, 1161, 3448, 3720, 3809, 3970], '(drug-resistant': [712], 'DRSP),': [715], 'raised': [717], 'problems': [719], 'concerning': [720], 'therapy': [721, 1509], 'especially': [725, 1506], 'intensive': [727], 'care': [728], 'units': [729, 2171, 2256], 'South': [735], 'America': [736], '(7Metlay': [737], 'J.P.': [738], 'Curr.': [739, 834], 'Opin.': [740], '2002;': [743, 1214, 1348, 1716, 1803, 1856, 1972, 2069, 2407], '15:': [744], '163-167Crossref': [745], '(36)': [748], 'For': [751, 2804, 3048, 3066, 3368, 3453, 3830, 3925], 'Gram-negative': [752, 893, 2619], 'shock': [758], 'been': [760, 1070, 1224, 1393, 1414, 1614, 1692, 2135, 2206, 2433, 4348], 'elucidated': [761], 'isolation': [764], 'outer': [768, 1490], 'membrane': [769, 1495, 2900], 'component': [770], '(LPS)1(8Glauser': [772], 'M.P.': [773, 1428], 'Zanetti': [774], 'G.': [775, 1515, 2189, 2225], 'Baumgartner': [776], 'J.D.': [777], 'Cohen': [778], 'Lancet.': [780], '1991;': [781, 1154, 1586, 1874], '338:': [782], '732-736Abstract': [783], '(663)': [786], '9Rietschel': [789], 'E.T.': [790, 846, 3796], 'Brade': [791, 795, 979, 1004, 3793], 'H.': [792, 814, 818, 980, 1005, 1290, 1658, 1749, 1901, 2276, 2393, 2652, 2872, 3704, 3949, 4048, 4390], 'Holst': [793], 'O.': [794, 1511, 1517, 1652, 1771, 2368, 4384], 'L.': [796, 3788, 3794], 'Muller-Loennies': [797], 'Mamat': [799], 'U.': [800, 802, 806, 820, 1513, 1634, 4068, 4366], 'Zahringer': [801], 'Beckmann': [803], 'F.': [804, 829, 1044], 'Seydel': [805], 'Brandenburg': [807], 'Ulmer': [809, 3797], 'A.J.': [810, 3798], 'Mattern': [811], 'T.': [812, 1339, 1579, 1707, 1847, 1867, 1969, 2004, 2065, 2187, 2223, 2270, 2551, 2646, 2685, 3426, 3469, 3707, 4042], 'Heine': [813, 3948], 'Schletter': [815], 'Loppnow': [817], 'Schonbeck': [819], 'Flad': [821, 3791], 'H.D.': [822, 3792], 'Hauschildt': [823], 'Schade': [825], 'U.F.': [826], 'Di': [827], 'Padova': [828], 'Kusumoto': [830], 'Schumann': [832, 3431, 3789], 'R.R.': [833, 919, 962, 1532, 2063, 2325, 3432, 3790], 'Top.': [835], 'Immunol.': [837, 966, 1103, 1213, 1347, 1715, 1735, 1777, 1855, 2104, 2333, 2374, 2879, 3801], '1996;': [838, 1448, 2122, 2160], '216:': [839], '39-81PubMed': [840], '10Alexander': [843], 'C.': [844, 1424, 1461, 1528, 1627, 1967, 2397, 3693, 4359], 'Rietschel': [845, 3795], 'Endotoxin': [848, 987, 1012, 1255], 'Res.': [849, 1256], '7:': [851, 1258], '167-202PubMed': [852], 'LPS,': [855, 4292], 'amphiphilic': [857, 1485], 'molecule': [858, 1280], 'or': [859, 958, 2445, 2961, 3005, 3012, 3025, 3031, 3335], 'glycolipid,': [860], 'commonly': [862, 1501], 'released': [863, 1502], 'growth': [867], 'death': [870], '(11Leeson': [871], 'M.C.': [872], 'Fujihara': [873], 'Y.': [874, 1292, 1327, 1335, 1695, 1703, 1835, 1843], 'Morrison': [875, 985, 1010, 1948], 'D.C.': [876, 986, 1011, 1949], 'Immun.': [878, 1432, 1585, 1601, 1660, 1873, 1889, 1951, 1971, 2121, 2159, 4392], '1994;': [879, 1433, 2106], '62:': [880, 1434], '4975-4980Crossref': [881], 'In': [885, 1356, 1376, 2166, 2237, 4225], 'bacteria,': [894], 'aggregates': [895], 'LPS': [897, 949, 1231, 1246, 1273, 1939, 2024, 2709, 2993, 3006, 3398, 3902, 4321], 'intact': [901], 'rapidly': [905], 'opsonized': [906], 'synthesized': [914, 2054], 'liver': [917], '(12Schumann': [918], 'Leong': [920], 'S.R.': [921], 'Flaggs': [922], 'G.W.': [923], 'Gray': [924], 'P.W.': [925], 'Wright': [926], 'S.D.': [927, 1110], 'Mathison': [928, 1117], 'J.C.': [929, 1118, 3945], 'Tobias': [930, 1113], 'P.S.': [931, 1114], 'Ulevitch': [932, 1115], 'R.J.': [933, 1116], 'Science.': [934, 1048, 1119], '1990;': [935, 1120, 2193, 2229], '249:': [936, 1121], '1429-1431Crossref': [937], '(1381)': [940], 'effectively': [944], 'catalyzes': [945], 'membrane-bound': [951], 'forms': [954, 1403], '(mCD14': [957], 'sCD14,': [959], 'Refs.': [960], '13Schumann': [961], 'Latz': [963, 3950], 'E.': [964, 1038, 1095, 1553, 2323, 2327, 2586, 3941, 3951], 'Chem.': [965, 1466, 1756, 1908, 2573, 3435], '74:': [968], '42-60Crossref': [969], '(88)': [972], '14Kitchens': [975], 'R.L.': [976], 'Munford': [977], 'Opal': [981, 1006], 'S.M.': [982, 1007, 1036, 1101], 'Vogel': [983, 1008], 'S.N.': [984, 1009], 'Health': [989, 1014], 'Disease.': [991, 1016], 'Marcel': [992, 1017], 'Dekker,': [993, 1018], 'Inc.,': [994, 1019], 'New': [995, 1020], 'York1999:': [996, 1021], '521Google': [997], '15van': [999], 'Deventer': [1000], 'S.J.H.': [1001], 'Pajkrt': [1002], 'D.': [1003, 1422, 1444, 1457, 1733, 2331], '379Google': [1022], 'GPI-anchored': [1024], 'mCD14': [1025], 'predominantly': [1027], 'expressed': [1028], 'monocytic': [1033, 4345], 'lineage': [1034], '(16Goyert': [1035], 'Ferrero': [1037, 1094], 'Rettig': [1039], 'W.J.': [1040], 'Yenamandra': [1041], 'A.K.': [1042], 'Obata': [1043], 'Le': [1045], 'Beau': [1046], 'M.M.': [1047], '1988;': [1049, 1104], '239:': [1050], '497-500Crossref': [1051], '(297)': [1054], 'profoundly': [1058], 'sensitizes': [1059], 'myeloid': [1060], 'minute': [1063], 'amounts': [1064, 1937], 'LPS.': [1066], 'it': [1068, 2289, 4134], 'predicted': [1071], 'require': [1073], 'co-receptor': [1075], 'initiation': [1078, 2515], 'cellular': [1080], 'signaling': [1081, 2419, 3937], 'lack': [1085], 'transmembrane': [1088], 'domain': [1089], '(17Haziot': [1090], 'A.': [1091, 1253, 1341, 1426, 1430, 1636, 1709, 1849, 1963, 2002, 2059, 2061, 2321, 2549, 2570, 2683, 3422, 3947, 4063, 4070, 4368], 'Chen': [1092], 'Low': [1096], 'M.G.': [1097], 'Silber': [1098], 'Goyert': [1100], '141:': [1105], '547-552PubMed': [1106], '18Wright': [1109], 'Ramos': [1111], 'R.A.': [1112], '1431-1433Crossref': [1122], '(3420)': [1125], '(TLR)-4': [1130], 'member': [1133], 'family': [1136], 'displaying': [1139, 4140], 'homology': [1140], 'their': [1142], 'cytoplasmic': [1143, 1494], 'domains': [1144], 'interleukin-1': [1147], '(19Gay': [1149], 'N.J.': [1150], 'Keith': [1151], 'Nature.': [1153, 2733], '351:': [1155], '355-356Crossref': [1156], '(458)': [1159], 'immunity': [1169], 'recognizing': [1171], 'molecular': [1172, 1362, 2085], 'patterns': [1173, 1363], 'wide': [1176], 'range': [1177, 4204], 'protozoan': [1181], 'species': [1182, 2133, 2621], 'molecules': [1184, 1381, 1486, 4214], 'related': [1185], 'viral': [1187], '(20Means': [1189], 'T.K.': [1190], 'Golenbock': [1191, 2330, 3958], 'D.T.': [1192, 3959], 'Fenton': [1193], 'M.J.': [1194], 'Cytokine': [1195], 'Growth': [1196], 'Factor': [1197], 'Rev.': [1198, 1212], '11:': [1200], '219-232Crossref': [1201], '(259)': [1204], 'Scholar,21Janeway': [1206], 'Medzhitov': [1209], 'Annu.': [1211], '197-216Crossref': [1216], '(6247)': [1219], 'identified': [1225], 'specific': [1228], 'leading': [1232], 'induction': [1235, 1572, 2478], 'release': [1237, 1266, 4413], 'pro-inflammatory': [1239, 4248], 'cytokines': [1240, 2036], 'monocytes': [1242, 1268, 4263, 4407], 'macrophages': [1244, 4342], 'upon': [1245], '(22Beutler': [1248], 'Du': [1250], 'X.': [1251], 'Poltorak': [1252], '277-280Crossref': [1259], 'To': [1263, 2956, 4079], 'induce': [1264, 2035, 2304], 'response': [1270, 2363], 'extracellular': [1272], 'TLR-4,': [1275, 1684, 2446, 2496], 'however,': [1276], 'accessory': [1278], 'host': [1279], 'termed': [1281], 'required': [1284], '(23Shimazu': [1285], 'Akashi': [1287, 1328, 1649, 1696, 1836, 4381], 'Ogata': [1289, 1332, 1700, 1840], 'Nagai': [1291], 'Fukudome': [1293], 'Miyake': [1295, 1344, 1712, 1728, 1852, 3956], 'Kimoto': [1297, 1342, 1710, 1850], 'M.': [1298, 1331, 1333, 1343, 1534, 1625, 1699, 1701, 1711, 1751, 1839, 1841, 1851, 1903, 3424, 3709, 4357], 'Exp.': [1300, 2006, 2067, 2553, 2687, 3711, 3961], '189:': [1303], '1777-1782Crossref': [1304], '(1760)': [1307], 'Scholar),': [1309, 1607, 1815, 1921, 2582, 2663, 2887, 4400], 'binds': [1311], 'high': [1313, 1927, 2029], 'affinity': [1314], 'ectodomain': [1317], 'affects': [1321], 'subcellular': [1322], 'distribution': [1323], '(24Nagai': [1326, 1694, 1834], 'Nagafuku': [1330, 1698, 1838], 'Iwakura': [1334, 1702, 1842], 'Akira': [1336, 1653, 1704, 1774, 1844, 2371, 4385], 'Kitamura': [1338, 1706, 1846], 'Kosugi': [1340, 1708, 1848], 'Nat.': [1346, 1714, 1854], '3:': [1349, 1717, 1857], '667-672Crossref': [1350, 1718, 1858], '(858)': [1353, 1721, 1861], 'contrast,': [1357, 2238], 'detailed': [1358], 'information': [1359, 2431], 'on': [1360, 1679, 1994, 2437, 2973, 3097, 3225, 3774, 4096], 'interacting': [1367], 'still': [1374, 1821], 'lacking.': [1375], 'several': [1377], 'previous': [1378], 'two': [1380, 3248, 4141], 'wall,': [1385], '(PG)': [1387], 'have': [1392, 1691, 1982, 2134, 4347], 'found': [1394, 2032, 2136, 3347], 'mediate': [1396], 'inflammatory': [1397], 'responses': [1398, 2518], 'host.': [1401], 'PG': [1402, 1612], 'murein': [1405], 'layer': [1406], 'wall': [1411], 'repeatedly': [1415], 'activate': [1418], '(25Heumann': [1421], 'Barras': [1423], 'Severin': [1425], 'Glauser': [1427], 'Tomasz': [1429, 2569, 4062], '2715-2721Crossref': [1435], '26Dziarski': [1439], 'Jin': [1441], 'Y.P.': [1442], 'Gupta': [1443, 1732], '174:': [1449], '(101)': [1453], '27Gupta': [1456], 'Wang': [1458, 1726], 'Q.': [1459, 1727, 1943], 'Vinson': [1460], 'Dziarski': [1462, 1746, 1898, 2328], '274:': [1468, 1758, 1910], '14012-14020Abstract': [1469], '(60)': [1477], 'class': [1483], 'anchored': [1487], 'face': [1491], 'growth,': [1505], 'under': [1507, 4301], 'antibiotic': [1508], '(28Schneider': [1510], 'Michel': [1512], 'Zysk': [1514], 'Dubuis': [1516], 'Nau': [1518, 1535], 'Neurology.': [1520], '53:': [1522], '1584-1587Crossref': [1523], '29Heer': [1527], 'Stuertz': [1529], 'Reinert': [1531], 'Mader': [1533], 'Infection.': [1537], '28:': [1539], '13-20Crossref': [1540], '(14)': [1543], '30van': [1546], 'Langevelde': [1547], 'P.': [1548, 1581, 1869, 3943], 'van': [1549], 'Dissel': [1550], 'J.T.': [1551], 'Ravensbergen': [1552], 'Appelmelk': [1554], 'B.J.': [1555], 'Schrijver': [1556], 'I.A.': [1557], 'Groeneveld': [1558], 'P.H.': [1559], '3073-3078Crossref': [1565], 'It': [1569], 'causes': [1570], 'phagocytes': [1575, 4253], '(31Bhakdi': [1576], 'Klonisch': [1578, 1866], 'Nuber': [1580, 1868], 'Fischer': [1582, 1594, 1870, 1882, 2116, 2154, 2271, 2647, 4043], 'W.': [1583, 1595, 1871, 1883, 2101, 2117, 2155, 2185, 2221, 2272, 2401, 2648, 4044], '59:': [1587, 1875], '4614-4620Crossref': [1588, 1876], '32Keller': [1592, 1880], 'Keist': [1596, 1884], 'Bassetti': [1598, 1886], '1992;': [1602, 1890, 2280, 2656, 4052], '60:': [1603, 1891], '3664-3672Crossref': [1604, 1892], 'synergism': [1610], 'resulting': [1616], 'higher': [1618, 4129], 'levels': [1620, 4294, 4325], '(33De': [1621, 4353], 'Kimpe': [1622, 4354], 'S.J.': [1623, 4355], 'Kengatharan': [1624, 4356], 'Thiemermann': [1626, 4358], 'Vane': [1628, 4360], 'J.R.': [1629, 4361], 'Proc.': [1630, 4064, 4362], 'Natl.': [1631, 4065, 4363], 'Acad.': [1632, 4066, 4364], '1995;': [1637, 4369], '92:': [1638, 4370], '10359-10363Crossref': [1639, 4371], '(298)': [1642, 4374], '34Yang': [1645, 4377], 'Tamai': [1647, 4379], 'Takeuchi': [1651, 4383], 'Sugawara': [1655, 4387], 'Takada': [1657, 4389], '69:': [1662, 1953, 4394], '2045-2053Crossref': [1663, 4395], '(184)': [1666, 4398], 'After': [1669, 2905, 2930, 3089, 3472, 3504, 3541, 3650, 3736], 'identification': [1671], 'TLRs,': [1673], 'controversial': [1677], 'reports': [1678], 'TLR-2,': [1683, 2495, 3986], 'LTA-induced': [1688], 'activation': [1690, 2305, 4249, 4285, 4339], 'published': [1693], '35Dziarski': [1724], 'Kirschning': [1730, 1752, 1904, 3429], 'C.J.': [1731, 1753, 1905, 3430, 3702], '166:': [1737], '1938-1944Crossref': [1738], '(182)': [1741], '36Schwandner': [1744, 1896], 'Wesche': [1748, 1900, 3703], 'Rothe': [1750, 1902, 3708], '17406-17409Abstract': [1759, 1911], '(1438)': [1767, 1919], '37Takeuchi': [1770], 'Hoshino': [1772, 2369], '165:': [1779, 2376], '5392-5396Crossref': [1780, 2377], '(911)': [1783, 2380], 'although': [1787], 'meanwhile': [1790], 'regarded': [1791], 'mediator': [1795], 'inflammation': [1797], '(38Ginsburg': [1798], 'I.': [1799, 1965, 2876], 'Lancet': [1800], '2:': [1804], '171-179Abstract': [1805], '(305)': [1813], 'recruitment': [1817], 'TLRs': [1819], 'unclear,': [1822], 'because': [1823], 'commercial': [1829], 'preparations': [1831, 2296, 2712, 3007, 3905], 'used': [1833, 4308], '31Bhakdi': [1864], 'display': [1925], 'degree': [1928], 'compositional': [1930], 'heterogeneity': [1931], 'but': [1932], 'contaminated': [1934], 'significant': [1936], '(39Gao': [1940], 'J.J.': [1941], 'Xue': [1942], 'Zuvanich': [1944], 'E.G.': [1945], 'Haghi': [1946], 'K.R.': [1947], '751-757Crossref': [1954], '(95)': [1957], '40Morath': [1960], 'Geyer': [1962, 2001, 2060, 2548, 2682], 'Spreitzer': [1964], 'Hermann': [1966], 'Hartung': [1968, 2003, 2064, 2550, 2684, 3425], '70:': [1973], '938-944Crossref': [1974], '(139)': [1977], 'Recently,': [1980], 'we': [1981, 4099, 4244, 4401], 'novel': [1985], 'purification': [1986, 2539, 4038], 'protocol': [1987, 2022, 2641], 'based': [1993, 3773], 'procedure': [1998, 3155], '(41Morath': [1999, 2546, 2680], '193:': [2009, 2556, 2690], '393-397Crossref': [2010, 2557, 2691], '(377)': [2013, 2560, 2694], 'aureusextracted': [2019], 'lacks': [2023], 'contamination,': [2025], 'being': [2027], 'purity': [2030, 4082], 'strongly': [2034], 'whole': [2040, 2294], 'assay.': [2042], 'These': [2043, 2383, 4152, 4208], 'results': [2044], 'confirmed': [2046], 'largely': [2048], 'analogous': [2049], 'obtained': [2051], 'chemically': [2053], '(42Morath': [2056], 'Stadelmaier': [2058], 'Schmidt': [2062], '195:': [2070], '1635-1640Crossref': [2071], '(210)': [2074], 'All': [2077, 3687], 'date': [2081], 'exhibit': [2082], 'common': [2084], 'architecture': [2086], 'consisting': [2087, 2252], 'diacylglycerol-containing': [2090], 'glycolipid': [2091], 'anchor': [2092], 'covalently': [2095], 'coupled': [2096], 'polymeric': [2097, 2150, 2240, 2250], 'backbone': [2098, 2151], 'structure': [2099], '(43Fischer': [2100], '(Berl.).': [2105], '183:': [2107], '61-76Crossref': [2108], '(134)': [2111], '44Greenberg': [2114], 'J.W.': [2115, 2153], 'Joiner': [2118, 2156], 'K.A.': [2119, 2157], '64:': [2123, 2161], '3318-3325Crossref': [2124, 2162], 'different': [2131, 2249, 4216], 'differ': [2138, 4031], 'chemical': [2141], 'composition': [2142], 'so-called': [2145], '“repeating': [2146], 'units”': [2147], '(44Greenberg': [2152], 'repeating': [2170, 2255], 'contain': [2172, 2258], 'd-alanine': [2173], 'α-d-N-acetylglucosamine': [2175], 'linked': [2176, 2262], 'central': [2179], 'linear': [2180], '1–3-linked': [2181], 'polyglycerophosphate': [2182], 'chain': [2183, 2241], '(45Fischer': [2184, 2220], 'Mannsfeld': [2186, 2222], 'Hagen': [2188, 2224], 'Biochem.': [2190, 2226, 2279, 2655, 2777, 4051], 'Cell': [2191, 2227], '68:': [2194, 2230], '33-43Crossref': [2195, 2231], '(89)': [2198, 2234], 'This': [2201, 2340], 'structural': [2202, 4085], 'motif': [2203], 'also': [2205, 4236], 'shown': [2207, 2291, 3411], 'be': [2209, 3349, 3413, 4177, 4307], 'valid': [2210], 'fromEnterococcus': [2213], 'spp.,': [2214], 'Bacillus': [2215], 'subtilis,': [2216], 'some': [2218, 3049, 3369, 3454, 3926], 'streptococci': [2219], 'exhibits': [2246], 'strikingly': [2248], 'structure,': [2251], 'tetrasaccharide': [2254], 'phosphorylcholine': [2259, 4175], 'each': [2264, 3122], 'other': [2265, 4034], 'ribitol': [2267], 'phosphate': [2268], '(46Behr': [2269, 2645, 4041], 'Peter-Katalinic': [2273, 2649, 4045], 'Egge': [2275, 2651, 4047], '207:': [2281, 2657, 4053], '1063-1075Crossref': [2282, 2658, 4054], '(123)': [2285, 2661, 4057], 'Recently': [2288], 'heat-killed': [2293], 'transcription': [2307], 'NF-κB': [2309, 3674, 3879], 'transfected': [2311, 3604, 3654, 3783], 'CHO': [2312, 3780, 3928], 'CD14-dependent': [2318], 'fashion': [2319], '(47Yoshimura': [2320], 'Lien': [2322, 3940], 'Ingalls': [2324], 'Tuomanen': [2326], '1-5Crossref': [2336], 'consistent': [2342], 'observation': [2345], 'TLR-2-deficient': [2347], 'mice': [2348, 2366, 2384], 'highly': [2350, 2387], 'susceptible': [2351, 2388], 'infection': [2353], 'compared': [2357, 4290, 4319], 'wild': [2360], 'type-like': [2361], 'TLR-4-deficient': [2365], '(37Takeuchi': [2367], 'furthermore': [2386], 'pneumococcal': [2390, 2523, 4028], 'meningitis': [2391], '(48Echchannaoui': [2392], 'Frei': [2394], 'Schnell': [2396], 'Leib': [2398], 'S.L.': [2399], 'Zimmerli': [2400], 'Landmann': [2402], '186:': [2408], '798-806Crossref': [2409], '(255)': [2412], 'particular': [2417], 'TLR': [2418], 'pathway': [2420], 'activated': [2421], 'remained': [2427], 'controversial,': [2428], 'no': [2430], 'available': [2434], 'yet': [2436], 'potential': [2439, 2492, 2616, 4247], 'contributions': [2440], 'system.': [2461], 'The': [2462, 3145, 3244, 3343], 'aim': [2463], 'study': [2466], 'analyze': [2469, 2957], 'andS.': [2485], 'aureus.': [2486], 'Of': [2487], 'further': [2488], 'interest': [2489], 'signal': [2500], 'transduction': [2501], 'show': [2506], 'involved': [2512], 'TLR-2-dependent': [2514], 'staphylococcal': [2521], 'DSM': [2529], '20233': [2530], '(SLTA)': [2531], 'using': [2540, 2745, 2944, 2985, 3770], 'HIC': [2541, 2670], 'chromatography': [2542, 2671], 'previously': [2545], 'strain': [2565], 'R6': [2566], '(49Holtje': [2567], 'J.V.': [2568, 4061], '1975;': [2574, 2880, 4071], '250:': [2575], '6072-6076Abstract': [2576], 'kindly': [2583, 3466, 3690], 'provided': [2584, 3467, 3691, 3727], 'Tuomanen,': [2587], 'St.': [2588], "Jude's": [2589], "Children's": [2590], 'Research': [2591], 'Hospital,': [2592], 'Memphis,': [2593], 'TN,': [2594], 'cultured': [2596, 3609, 3648, 3745, 3811, 3835], 'CSL': [2598], 'late': [2601], 'log': [2602], 'phase': [2603], 'harvested': [2605], 'centrifugation': [2607, 3269], 'at': [2608, 2856, 2901, 2927, 3008, 3042, 3060, 3082, 3091, 3112, 3138, 3177, 3234, 3238, 3255, 3258, 3271, 3275, 3384, 3500, 3523, 3537, 3550, 3557, 3588, 3640, 3836, 4219, 4309], '3000': [2609], '×': [2610, 3236, 3273, 3642, 3841], 'g.': [2611], 'Integrity': [2612], 'contaminations': [2617], 'checked': [2623], 'Gram': [2625], 'staining': [2626, 2771, 2788, 2795, 3191, 4118, 4124, 4138, 4234], 'microscopy.': [2628], 'Pneumococcal': [2629], '(PLTA)': [2631, 4030], 'extracted': [2633, 4091], 'defrozen': [2635], 'earlier': [2644, 3408], 'then': [2665], 'extracts': [2666], 'Polyacrylamide': [2697], 'stacking': [2698], 'gels': [2699, 2703, 2762, 2808, 3127, 3196], '(5%)': [2700], 'separating': [2702], '(16%)': [2704], 'cast': [2706], 'without': [2707, 3023, 3755, 3849, 3858, 4280], 'SDS.': [2708], 'mixed': [2714], '4×': [2716, 3100], 'sample': [2717, 3102, 3123], 'buffer': [2718, 2813, 3103, 3132], 'loaded': [2720], 'onto': [2721], 'gel,': [2723], 'electrophoresis': [2725, 2982], 'performed': [2727, 2790, 2984, 3111, 3198, 3322, 3392, 3752, 3889, 4100], 'according': [2728, 2755, 3199], 'Laemmli': [2730], '(68Laemmli': [2731], 'U.K.': [2732], '1970;': [2734], '227:': [2735], '680-685Crossref': [2736], '(207538)': [2739], 'Gels': [2742], 'stained': [2744, 4237], 'BioRad': [2747], 'Silver': [2748], 'Stain': [2749], 'Plus': [2750], 'kit': [2751, 2796, 3772], '(BioRad,': [2752, 2797], 'Munich,': [2753, 2798, 3698, 3699], 'Germany)': [2754, 2799, 2852, 3041, 3231, 3294, 3380, 3532, 3549], 'manufacturers': [2758], 'except': [2760, 3721], 'oxidized': [2764], '0.7%': [2766], 'periodic': [2767, 4101, 4231], 'prior': [2769, 3381, 4351], '(50Tsai': [2772], 'C.M.': [2773], 'Frasch': [2774], 'C.E.': [2775], 'Anal.': [2776], '1982;': [2778], '119:': [2779], '115-119Crossref': [2780], '(2317)': [2783], 'Colloidal': [2786], 'gold': [2787, 2794, 4157], 'colloidal': [2793], 'following': [2800], "manufacturer's": [2802, 2954, 3202], 'protocol.': [2803, 2955, 3203], 'anti-phosphorylcholine': [2805, 4107], 'Western': [2806, 4108, 4170], 'blotting,': [2807], 'immersed': [2810], 'containing': [2814, 2845, 3080, 3288, 3508, 3617, 3976], '25': [2815], 'mmol/liter': [2816, 2819], 'Tris-HCl,': [2817], '200': [2818], 'glycine,': [2820], '20%': [2821], 'methanol,': [2822], 'transferred': [2824, 3634], 'Hybond-C': [2826], 'extra': [2827], 'membranes': [2828], '(Amersham': [2829, 2942, 2948, 2989], 'Biosciences)': [2830, 2943, 2949], 'semidry': [2832], 'blotting': [2833, 4109], '(Hölzel': [2834], 'GmbH,': [2835], 'Dorfen,': [2836], 'Germany).': [2837, 3597], 'Membranes': [2838], 'blocked': [2840], '(PBS)': [2844], '2%': [2846, 3289], 'bovine': [2847, 2893, 2917], 'albumin': [2849, 2895, 3291], '(Roth,': [2850], 'Braunschweig,': [2851], '2': [2854, 3303, 3521], 'h': [2855, 2926, 3522, 3887, 3914], 'room': [2857, 2928, 3524, 3558], 'temperature': [2858, 3559], 'washed': [2860, 3247, 3854, 3898], 'three': [2861, 3307], 'times.': [2862], 'TEPC-15': [2863], '(Sigma),': [2864, 2912], 'phosphorylcholine-specific': [2866, 4169, 4240], 'IgA-antibody': [2867], 'murine': [2869, 4341], 'ascites': [2870], '(51Cosenza': [2871], 'Quintans': [2873], 'Lefkovits': [2875], '5:': [2881], '343-349Crossref': [2882], '(37)': [2885], 'diluted': [2889, 2913, 3215, 3284, 3493], '1:250': [2890], 'PBS/2%': [2892, 2916], 'incubated': [2897, 2923, 3017, 3296, 3373, 3536, 3556], '4': [2902, 3113, 3473, 3501, 3538, 3681, 3737], '°C': [2903, 3044, 3093, 3114, 3179, 3240, 3260, 3277, 3386, 3502, 3539], 'overnight.': [2904, 3503, 3540, 3649, 3749, 3851], 'washing,': [2906, 3542, 3651], 'rabbit': [2908, 3490], 'anti-murine': [2909], 'IgA': [2910], '1:2000': [2914], 'albumin,': [2919], 'added': [2921, 3059, 3534, 3554], '1': [2925, 3119, 3561, 3907, 4206], 'temperature.': [2929], 'final': [2932, 3084, 3172], 'washing': [2933, 3308], 'step,': [2934], 'bands': [2935, 4144, 4185, 4198, 4209, 4228], 'visualized': [2937], 'ECL': [2940, 2946], 'Hyperfilm': [2945], 'films': [2947], 'recommended': [2951], 'binding': [2958], 'PLTA': [2960, 3394, 4089, 4188, 4271], 'SLTA': [2962, 4273], '(sCD14)': [2966], 'investigate': [2969], 'effects': [2970, 3982, 3993, 4330], 'complex': [2974], 'formation,': [2975], 'automated': [2977, 3116, 3189], 'form': [2978], 'non-denaturing': [2980], 'Phastsystem™': [2987], 'apparatus': [2988], 'Biosciences).': [2990], 'Highly': [2991], 'Escherichia': [2995], 'coli': [2996], '515': [2997], 'analyzed': [2999, 3079], 'control.': [3002, 3452], 'Briefly,': [3003], 'concentrations': [3009, 4310], '1.25': [3011], '0.0625': [3013], 'μg/μl,': [3014], 'respectively,': [3015], '(d-PBS': [3022], 'magnesium': [3024], 'calcium;': [3026], 'Invitrogen)': [3027, 3519, 3616], 'absence': [3030, 4161, 4267], 'presence': [3032, 3329, 4173], '0.25': [3034, 3087], 'μg/μl': [3035], 'recombinant': [3036, 3051, 3336, 3528], 'sCD14': [3038, 3148], '(Biometec,': [3039], 'Greifswald,': [3040], '37': [3043, 3092], '10': [3046], 'min.': [3047, 3243, 3263, 3280, 3389, 3573], 'experiments': [3050, 3320, 4258], '(Xoma': [3054, 3339], 'Corp.,': [3055, 3340], 'Berkeley,': [3056, 3341], 'CA)': [3057], 'concentration': [3062, 3085, 3173], '0.025': [3064], 'μg/μl.': [3065, 3088], 'analysis': [3067, 4105], 'ligands,': [3073], 'set': [3075], 'samples': [3077, 3094, 3161, 3526], 'incubation': [3090, 3154, 3565], 'placed': [3096], 'ice': [3098], '(pH': [3104], '7.6)': [3105], 'added.': [3107], 'Native': [3108], 'PhastGelTMelectrophoresis': [3109], 'application': [3117], 'μl': [3120], 'Homogeneous-20': [3126], 'equipped': [3128], 'strips.': [3133], 'Electrophoretic': [3134], 'separation': [3135], 'done': [3137], 'constant': [3140], 'voltage': [3141], '400': [3143, 3625, 3826], 'V.': [3144], 'integrity': [3146, 4086], 'proteins': [3151], 'adjusting': [3159], 'denaturing': [3163], 'conditions': [3164], 'addition': [3167], 'SDS': [3169, 3185, 3195], '2%,': [3175], 'heating': [3176], '95': [3178], '5': [3181, 3262, 3488, 3551, 3840], 'min,': [3182], 'Following': [3187], 'electrophoresis,': [3188], 'silver': [3190, 4103, 4123, 4233], 'Blood': [3204], 'healthy': [3206], 'donors': [3207], 'drawn': [3209], 'heparin': [3211], '(50': [3212], 'units/ml)': [3213], '1:2': [3216], 'RPMI': [3218, 3251, 3286, 3311], '1640': [3219, 3252, 3287, 3312], '(Invitrogen).': [3220, 3628, 3686, 3829, 3980], '30': [3221, 3388, 3572], 'ml': [3222, 3908], 'layered': [3224], '15-ml': [3226], 'Pancoll': [3227], '(PAN': [3228], 'Biotech,': [3229], 'Aidenbach,': [3230], 'centrifuged': [3233, 3254], '600': [3235, 3256], 'g': [3237, 3274], '21': [3239, 3259, 3276], '15': [3242, 3279], 'interphase': [3245], 'times': [3249], '×g': [3257], 'Thrombocytes': [3264], 'separated': [3266], 'another': [3268], 'step': [3270], '100': [3272, 3495, 3977], 'Remaining': [3281], '(Immuno,': [3292], 'Heidelberg,': [3293], '96-well': [3298], 'tissue': [3299, 3637, 3846], 'culture': [3300, 3638, 3847], 'plates': [3301, 3484, 3639, 3848], 'h,': [3304, 3474, 3562, 3738], 'steps': [3309], 'order': [3314], 'remove': [3316], 'non-adherent': [3317], 'cells.': [3318], 'Stimulation': [3319, 3390, 3750], '100-μl': [3325], 'volume': [3326], '2.5%': [3331], '(Sigma)': [3334, 3403, 3512], 'CA).': [3342], 'preparation': [3345, 4090, 4189], 'devoid': [3350, 3414], 'any': [3352, 3416, 4033], 'endotoxin': [3353], 'contamination': [3354, 3418, 4164], 'kinetic': [3357], 'chromogenic': [3358], 'limulus': [3359], 'amoebocyte': [3360], 'lysate': [3361], '(LAL)': [3362], 'test': [3363], '(Bio': [3364], 'Whittaker,': [3365], 'Verviers,': [3366], 'Belgium).': [3367], 'experiments,': [3370, 3455, 3832, 3927], 'anti-CD14': [3375, 3995], 'My4': [3377, 3997], '(Coulter,': [3378], 'Hamburg,': [3379, 3548], '36': [3385, 4148, 4183], 'SLTA.': [3396], 'S-Form': [3397], 'Salmonella': [3401], 'minnesota': [3402], 'employed': [3404], 'us': [3406], 'lipoprotein': [3417], '(52Michelsen': [3419], 'K.S.': [3420], 'Aicher': [3421], 'Mohaupt': [3423], 'Dimmeler': [3427], '276:': [3437], '25680-25686Abstract': [3438], '(247)': [3446], 'served': [3449], 'preincubated': [3458], '(MDP,': [3461], 'Bachem,': [3462], 'King': [3463], 'Prussia,': [3465], 'Hartung,': [3470], 'Konstanz).': [3471], 'supernatants': [3475], 'subjected': [3477], 'ELISA.': [3479], 'Nunc': [3480], 'Maxi': [3481], 'Sorp': [3482], 'ELISA': [3483, 3593], 'coated': [3486], 'μg/ml': [3489, 3552, 3626, 3827, 3978], 'anti-hTNF-α': [3491, 3544], 'Ab': [3492, 3996], 'mm': [3496], 'NaHCO3,': [3497], 'pH': [3498], '8.3': [3499], 'blocking': [3505], 'PBS': [3507], '0.05%': [3509], 'Tween': [3510], '20': [3511], '10%': [3514, 3618], '(FCS,': [3518], 'temperature,': [3525], 'TNF-α': [3529, 3577, 4275], '(R&D,': [3530], 'Wiesbaden,': [3531], 'biotinylated': [3543], '(BD': [3546], 'Pharmingen,': [3547], 'streptavidin-peroxidase': [3567], '(1': [3568], 'μg/ml,': [3569], 'Sigma)': [3570], 'Detection': [3574], 'bound': [3576], 'carried': [3579], 'out': [3580], 'ortho-phenylen-diphosphate': [3582], '(OPD,': [3583], 'Sigma,)': [3584], 'measurement': [3587, 3919], '490': [3589], 'nm': [3590], 'reader': [3594], '(Tecan,': [3595], 'Crailsheim,': [3596], 'Wild-type': [3598, 3779], 'HEK293': [3599], 'stably': [3603, 3782], '(DMEM,': [3615], 'FCS,': [3619], 'transfectants': [3620, 3821], 'additionally': [3622, 3823], 'supplemented': [3623, 3824], 'G418': [3627, 3828, 3850], 'Prior': [3629], 'transfection,': [3631], '12-well': [3636, 3845], '3.5': [3641], '104': [3643, 3842], 'per': [3645], 'plasmids': [3656, 3688, 3864], 'encoding': [3657, 3865], 'hTLR-2': [3659, 3867], '(0.002': [3660, 3663], 'μg),': [3661, 3664, 3670, 3869, 3872, 3875], 'hTLR-4': [3662], 'hMD-2': [3665, 3723], '(0.002–0.05': [3666], 'μg)': [3667, 3679, 3884], 'β-galactosidase': [3668, 3764, 3873, 3921], '(0.1': [3669, 3874], 'ELAM': [3673, 3878], 'luciferase': [3675, 3766, 3880, 3923], 'reporter': [3676, 3881], 'plasmid': [3677, 3882], '(0.25': [3678, 3883], 'μl/well': [3682, 3892], 'LipofectAMINE®': [3683], 'reagent': [3685], 'Kirschning,': [3695], 'Technical': [3696], 'University': [3697, 3731], 'Germany': [3700], '(69Kirschning': [3701], 'Merrill': [3705], 'Ayres': [3706], '188:': [3714], '2091-2097Crossref': [3715], '(655)': [3718], 'plasmid,': [3724], 'Miyake,': [3730], 'Tokyo,': [3733, 3734], 'Japan.': [3735], 'changed,': [3741], 'DMEM/10%': [3747], 'FCS': [3748, 3756, 3859], 'DMEM': [3754], '16': [3758, 3886], 'h.': [3759], 'Cells': [3760, 3852, 3896], 'lysed,': [3762], 'activity': [3767], 'measured': [3769], 'chemiluminescence': [3775], '(Roche': [3776], 'Molecular': [3777, 3894], 'Biochemicals).': [3778, 3895], '(53Hamann': [3787], '30:': [3803], '211-216Crossref': [3804], '(12)': [3807], "Ham's": [3813, 3856, 3910, 3974], 'nutrient': [3814], 'F12': [3816], '(PAA,': [3817], 'Linz,': [3818], 'Austria),': [3819], 'density': [3838], 'cells/well': [3843], 'expression': [3863], '(0.01': [3868, 3871], 'hCD14': [3870], '0.8': [3891], 'FuGENE®(Roche': [3893], 'stimulated': [3900], '24': [3913], 'lysis': [3917], 'activity.': [3924], 'expressing': [3930], 'mutant': [3932], 'defective': [3934], 'LPS-induced': [3936], '(54Schromm': [3938], 'A.B.': [3939], 'Henneke': [3942], 'Chow': [3944], 'Yoshimura': [3946], 'Monks': [3952], 'B.G.': [3953], 'Schwartz': [3954], 'D.A.': [3955], '194:': [3964], '79-88Crossref': [3965], '(243)': [3968], 'cultivated': [3972], 'Hygromycin': [3979], 'Enhancing': [3981], 'inhibitory': [3992], 'statistically': [3999], 'evaluated': [4000], "Student's": [4003], 't': [4004], 'test.': [4005], 'Throughout': [4006], 'figures,': [4008], 'p': [4009, 4018], 'values': [4010, 4019], '<0.05': [4012], 'indicated': [4014], 'asterisk,': [4017], '<0.01': [4021], 'double': [4023], 'asterisks.': [4024], 'Isolation': [4025], 'procedures': [4026], 'known': [4035], 'protocols': [4036], '55Holtje': [4060], '72:': [4072], '1690-1694Crossref': [4073], '(136)': [4076], 'assess': [4080], 'octyl': [4097], 'Sepharose,': [4098], 'acid-sensitized': [4102, 4232], 'stain': [4104, 4155], '(Fig.1).': [4110], 'displays': [4115], 'faint': [4117], 'pattern': [4119, 4139], 'when': [4120], 'treated': [4121], 'reagents.': [4125], 'Because': [4126], 'carbohydrate': [4130], 'content': [4131], 'PLTA,': [4133], 'exhibited': [4135], 'stronger': [4137], 'distinct': [4142], '∼31': [4146], 'kDa': [4149, 4203], 'size.': [4151], 'failed': [4153], 'colloid,': [4158], 'indicating': [4159], '(Fig.': [4165, 4205], '1).': [4166], 'Employing': [4167], 'blot,': [4171], 'could': [4176], 'demonstrated': [4178], '31': [4181], 'kDa-size': [4184], 'series': [4195], 'minor': [4197], 'distributed': [4199], '17–40': [4202], 'C).': [4207], 'likely': [4211], 'represent': [4212], 'size': [4217], 'present': [4218], 'lower': [4220], 'quantities': [4221], 'within': [4222], 'preparation.': [4224], 'fact,': [4226], 'all': [4227], 'detected': [4229], 'immunodetection': [4241], 'method.': [4242], 'First,': [4243], 'tested': [4245, 4402], '(PBMCs)': [4264], 'serum.': [4269], 'Both': [4270, 4416], 'dose-dependent': [4278], 'manner': [4279], 'substantial': [4281], 'differences': [4282], 'profiles': [4286], '(Fig.2': [4287], 'A).': [4288], 'As': [4289], 'lower,': [4299], 'serum-free': [4302], 'conditions,': [4303], 'had': [4305], 'up': [4312], '3': [4314], 'orders': [4315], 'magnitude': [4317], 'greater': [4318], 'elicit': [4323], 'TNF-α.': [4327], 'Since': [4328], 'synergistic': [4329], 'partial': [4335], 'structures': [4336], 'reported': [4349], 'whether': [4403], 'preincubation': [4404], '(MDP)': [4410], 'affected': [4411], 'prep': [4417]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2079605309', 'counts_by_year': [{'year': 2024, 'cited_by_count': 20}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 26}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 29}, {'year': 2016, 'cited_by_count': 27}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 43}, {'year': 2013, 'cited_by_count': 38}, {'year': 2012, 'cited_by_count': 33}], 'updated_date': '2024-12-29T20:49:06.809624', 'created_date': '2016-06-24'}