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134, 165, 217, 482, 580, 747, 1356, 1647, 1741, 1772, 1815, 2090, 2116, 2137, 2183], 'phase.': [9, 135, 2065, 2138], 'This': [10, 136, 301], 'has': [11, 137, 592, 689, 1345, 1657], 'been': [12, 138, 585, 593, 690, 2673, 3257], 'thought': [13, 139], 'to': [14, 59, 140, 185, 369, 587, 602, 612, 677, 692, 745, 1184, 1256, 1305, 1596, 1697, 1770, 2054, 2083, 2248, 2353, 2357, 2641, 2675, 2870, 2881, 2927, 2931, 2947, 2984, 2995, 3079, 3128, 3146, 3164, 3190, 3259, 3373, 3406], 'be': [15, 141, 613, 693, 743, 1543, 1568, 1597, 1880, 1997, 2102, 2351, 2354, 2676, 2686, 2928, 3035], 'a': [16, 142, 304, 389, 462, 469, 679, 873, 1119, 1306, 1335, 1346, 1688, 1749, 1776, 1847, 2024, 2186, 2629, 2687, 2719, 2749, 2765, 2882, 2978, 2991, 3075, 3091, 3139], 'simple': [17, 143], 'consequence': [18, 144], 'of': [19, 52, 55, 69, 84, 94, 122, 145, 178, 181, 195, 210, 220, 248, 257, 263, 357, 400, 465, 472, 673, 681, 696, 700, 750, 759, 792, 795, 800, 817, 1324, 1428, 1488, 1493, 1617, 1661, 1690, 1725, 1739, 1744, 1756, 1762, 1775, 1832, 1858, 1864, 1876, 1939, 1952, 1967, 1991, 2014, 2019, 2043, 2057, 2070, 2072, 2108, 2120, 2174, 2189, 2215, 2218, 2253, 2284, 2361, 2505, 2528, 2634, 2653, 2659, 2661, 2701, 2707, 2722, 2748, 2752, 2857, 2913, 2934, 2943, 2952, 3001, 3013, 3016, 3040, 3068, 3094, 3125, 3152, 3174, 3188, 3240, 3244, 3250, 3252, 3359, 3371, 3434], 'ςS': [20, 33, 146, 159, 615, 701, 1318, 1494, 1547, 1616, 1643, 1746, 1783, 1823, 1865, 2096, 2130, 3189, 3194, 3372], 'itself': [21, 147, 616], 'requiring': [22, 32, 148, 158], 'its': [25, 151, 620, 3375], 'production.': [26, 152], 'By': [27, 153], 'using': [28, 154, 1327, 1729, 2123, 2764], 'four': [29, 155], 'model': [30, 156, 774, 2883], 'normal': [35, 161], 'phase,': [40, 166, 1986], 'we': [41, 167, 1389, 1536, 1621, 1734, 1974, 2022, 2736, 3004], 'demonstrate': [42, 168, 762, 1537, 2199], 'that': [43, 90, 106, 169, 216, 232, 598, 764, 771, 811, 1350, 1392, 1402, 1486, 1530, 1538, 1570, 1736, 1748, 1854, 1959, 1976, 2104, 2201, 2415, 2425, 2541, 2664, 2683, 2690, 2713, 2854, 2861, 2915, 2989, 3007, 3122, 3138, 3158, 3228], 'ςS-dependent': [44, 70, 170, 196, 683, 751, 773, 1348, 1430, 1489, 1625, 1670, 1954, 3070, 3192, 3234, 3261], 'even': [48, 174, 788, 2211], 'presence': [51, 177, 791, 2214, 3239], 'high': [53, 179, 1508, 2068, 2216], 'levels': [54, 121, 180, 247, 699, 794, 1192, 1556, 2042, 2056, 2217, 3243], 'ςSproduced': [56, 182], 'ectopically.': [57, 183], 'Similar': [58, 184, 1769], 'ς70-dependent': [60, 98, 186, 224, 473, 814, 1665], 'under': [62, 188], 'positive': [63, 189, 463, 2016, 2645, 2705, 2720, 2750], 'control': [64, 103, 110, 190, 229, 236, 262, 302, 360, 2018, 2243], 'by': [65, 77, 115, 191, 203, 241, 367, 396, 595, 756, 807, 1132, 1197, 1273, 1312, 1331, 1501, 1545, 1844, 1885, 2196, 2244, 2532, 2545, 2578, 2668, 2693, 2884, 2919, 3170], 'ppGpp,': [66, 192, 365], 'requirement': [68, 194, 799, 1612, 1950, 2203], 'this': [73, 199, 476, 591, 737, 765, 830, 1393, 1411, 1429, 1637, 1718, 1730, 1757, 1812, 1944, 1960, 2009, 2073, 2202, 2519, 2684, 2696, 2738, 2864, 3002, 3032, 3441], 'alarmone': [74, 200, 456, 2865], 'is': [75, 201, 362, 739, 766, 805, 1236, 1351, 1639, 1664, 1819, 1852, 2003, 2081, 2092, 2114, 2221, 2246, 2691, 2739, 2852, 2909, 2945, 3132, 3144, 3156], 'bypassed': [76, 202], 'specific': [78, 204], '"stringent"': [79, 205], 'mutations': [80, 206], 'β-subunit': [83, 209], 'RNA': [85, 211, 252, 370, 1931, 2936], 'polymerase.': [86, 212, 2937], 'The': [87, 213, 354, 455, 824, 879, 1233, 1342, 1426, 1631, 1873, 2337, 2657, 3353], 'results': [88, 214, 3029], 'suggest': [89, 215], 'phase': [92, 218, 483, 581, 748, 1357, 1648, 1742, 1773, 1816, 2091, 2117, 2184], 'both': [95, 221, 1694, 1782, 2642, 3400], 'ςS-': [96, 222], 'and': [97, 105, 119, 223, 231, 245, 336, 341, 468, 484, 537, 770, 780, 889, 934, 1014, 1019, 1124, 1151, 1259, 1301, 1316, 1334, 1388, 1419, 1491, 1564, 1615, 1629, 1644, 1666, 1716, 1747, 1784, 1840, 2033, 2129, 2143, 2158, 2185, 2580, 2644, 2670, 2679, 2886, 2921, 2976, 3043, 3103, 3137, 3247, 3366, 3425, 3437], 'genes': [99, 225, 474, 752, 1490, 2173, 3377], 'requires': [100, 226, 617, 1395, 1408, 1866, 2127], 'stringent': [102, 228, 261, 359, 1404, 1935, 2017, 2257, 2421, 2955, 3159, 3354], 'modulon': [104, 230, 361], 'stringency': [107, 233, 2128], 'confers': [108, 234], 'dual': [109, 235, 1611], 'on': [111, 237, 1432, 1498, 1642, 1781, 1822, 2095, 2648, 2754, 2859, 3019], 'RpoS': [113, 239, 605], 'regulon': [114, 240], 'affecting': [116, 242], 'promoter': [117, 243, 1349, 1541, 1576, 1634, 1980, 2339, 2427, 2529, 2635], 'activity': [118, 244, 1235, 1981, 2010], 'required': [124, 250], 'ς-factor.': [125, 251], 'polymerase': [253, 371, 1932], 'RNAP': [254, 2255, 2289, 2424, 2671, 2878, 2907, 2953, 2981, 3087, 3096], 'core': [255], 'Cells': [256], 'Escherichia': [258, 334, 1012], 'coli': [259, 335, 826, 1013, 2176], 'elicit': [260], 'ribosome': [264], 'production': [265, 621], 'during': [266, 311, 481, 822, 1984, 2079, 3011], 'amino': [267, 528, 892], 'acid': [268, 529], 'starvation': [269, 313, 485], '(1.Sands': [270], 'M.K.': [271], 'Roberts': [272], 'R.B.': [273], 'J.': [274, 416, 498, 559, 632, 646, 706, 714, 726, 845, 902, 964, 1105, 1135, 1156, 1200, 1278, 1380, 1447, 1461, 1587, 1700, 1708, 2298, 2371, 2440, 2590, 2835, 3109, 3209, 3271, 3385], 'Bacteriol.': [275, 633, 647, 715, 727, 903, 965, 1381, 1448, 1462, 1588, 1709, 3386], '1952;': [276], '63:': [277, 448, 2330, 2403, 2472, 2568, 2622], '505-511Crossref': [278], 'PubMed': [279, 296, 422, 450, 507, 518, 568, 637, 651, 665, 719, 731, 907, 953, 969, 987, 1066, 1097, 1111, 1228, 1369, 1385, 1452, 1466, 1480, 1525, 1592, 1681, 1713, 1800, 1903, 1923, 2273, 2304, 2332, 2377, 2405, 2446, 2474, 2493, 2570, 2596, 2624, 2786, 2805, 2828, 2846, 2902, 2971, 3059, 3115, 3220, 3282, 3313, 3348, 3390], 'Google': [280, 299, 386, 425, 453, 508, 521, 569, 638, 652, 668, 720, 734, 908, 956, 970, 990, 1069, 1100, 1114, 1231, 1372, 1386, 1453, 1467, 1483, 1528, 1593, 1684, 1714, 1803, 1906, 1926, 2276, 2307, 2335, 2380, 2408, 2449, 2477, 2496, 2573, 2599, 2627, 2789, 2808, 2831, 2849, 2905, 2974, 3062, 3118, 3223, 3285, 3302, 3316, 3351, 3391], 'Scholar,': [281, 426, 509, 639, 653, 721, 1373, 1454, 1468, 1907, 2308, 2381, 2450, 2478, 2600, 2790, 2809, 2832, 3286, 3303, 3317], '2.Stent': [282], 'G.S.': [283], 'Brenner': [284], 'S.': [285, 291, 493, 554, 1898, 2268, 2488, 2781, 2800, 2823, 2897, 2966, 3054, 3202, 3264, 3290, 3343, 3382], 'Proc.': [286, 1893, 2263, 2483, 2776, 2795, 2818, 2892, 2961, 3049, 3338], 'Natl.': [287, 1894, 2264, 2484, 2777, 2796, 2819, 2893, 2962, 3050, 3339], 'Acad.': [288, 1895, 2265, 2485, 2778, 2797, 2820, 2894, 2963, 3051, 3340], 'Sci.': [289, 1896, 2266, 2486, 2779, 2798, 2821, 2895, 2964, 3052, 3341], 'U.': [290, 1897, 2267, 2487, 2780, 2799, 2822, 2896, 2965, 3053, 3342], 'A.': [292, 378, 659, 943, 959, 977, 1359, 1375, 1474, 1582, 1790, 1899, 1913, 2269, 2489, 2782, 2801, 2824, 2898, 2967, 3055, 3208, 3270, 3294, 3327, 3337, 3344, 3384], '1961;': [293], '47:': [294], '2005-2014Crossref': [295], 'Scopus': [297, 384, 423, 451, 519, 666, 732, 954, 988, 1067, 1098, 1112, 1229, 1370, 1481, 1526, 1682, 1801, 1904, 1924, 2274, 2305, 2333, 2378, 2406, 2447, 2475, 2494, 2571, 2597, 2625, 2787, 2806, 2829, 2847, 2903, 2972, 3060, 3116, 3221, 3283, 3300, 3314, 3349], '(231)': [298], 'Scholar).': [300, 353, 454, 522, 570, 669, 735, 909, 1178, 1232, 1594, 1685, 1804, 2336, 2409, 2497, 2574, 2850, 3352, 3392], 'encompasses': [303], 'rapid': [305, 390], 'reduction': [306, 391, 2524, 2630], 'superfluous': [308], 'rRNA': [309, 393, 406, 2512], 'biosynthesis': [310], 'cellular': [312], '(3.Cashel': [314], 'M.': [315, 331, 489, 497, 550, 558, 631, 657, 993, 1009, 1446, 1472, 3108, 3292, 3333], 'Gentry': [316, 994], 'D.R.': [317, 623, 995, 1438], 'Hernandez': [318, 624, 996, 1439, 3102], 'V.J.': [319, 625, 997, 1440, 3106], 'Vinella': [320, 998], 'D.': [321, 350, 374, 643, 710, 999, 1028, 1458, 1704], 'Neidhardt': [322, 900, 1000], 'F.C.': [323, 901, 1001], 'Ingraham': [324, 1002], 'J.L.': [325, 1003], 'Low': [326, 1004], 'K.B.': [327, 1005], 'Magasanik': [328, 1006], 'B.': [329, 1007], 'Schaechter': [330, 1008], 'Umberger': [332, 1010], 'H.E.': [333, 1011, 2834], 'Salmonella': [337, 1015], 'typhimurium': [338, 1016], ':': [339, 1017], 'Cellular': [340, 1018], 'Molecular': [342, 850, 1020, 1138, 1161, 1203, 1283, 1340], 'Biology.': [343, 1021], 'American': [344, 1022], 'Society': [345, 1023], 'Microbiology': [347, 1025], 'Press,': [348, 861, 1026, 1144, 1172, 1209, 1294], 'Washington,': [349, 1027], 'C.1996:': [351, 1029], '1458-1496Google': [352, 1030], 'effector': [355, 464], 'molecule': [356], 'guanosine': [363], 'tetraphosphate,': [364], 'which,': [366, 607, 1662], 'binding': [368], '(RNAP)1': [372], '(4.Chatterji': [373], 'Fujita': [375, 3205, 3267], 'N.': [376, 3206, 3268], 'Ishihama': [377, 3207, 3269, 3293], 'Genes': [379], 'Cells.': [380], '1998;': [381, 419, 447, 950, 966, 984, 1366, 1382, 1589, 1797, 1900, 2270, 2301, 2329, 2374, 2402, 2443, 2471, 2490, 2567, 2593, 2621, 2899, 2968, 3056, 3387], '5:': [382], '279-287Crossref': [383], '(139)': [385], 'Scholar),': [387, 1300, 1387, 1927, 2628, 2906, 2975, 3224], 'causes': [388], 'transcription,': [394, 536, 2085], 'probably': [395], 'reducing': [397], 'stability': [399, 2283, 2633], 'open': [402, 2286, 2344, 2428, 2530, 2636], 'promoter/RNAP': [403], 'complexes': [404, 2429, 2531, 2637, 2660], 'at': [405, 876, 1548, 1987, 2987], '(5.Bartlett': [408, 2290, 2363, 2432, 2582], 'M.S.': [409, 2291, 2364, 2433, 2583], 'Gaal': [410, 429, 2292, 2311, 2365, 2384, 2434, 2453, 2549, 2584, 2603], 'T.': [411, 430, 511, 849, 947, 963, 981, 1160, 1221, 1282, 1363, 1379, 1586, 1794, 1917, 2293, 2312, 2366, 2385, 2435, 2454, 2550, 2585, 2604, 3319], 'Ross': [412, 439, 2294, 2321, 2367, 2394, 2436, 2463, 2559, 2586, 2613], 'W.': [413, 440, 2295, 2322, 2368, 2395, 2437, 2464, 2560, 2587, 2614], 'Gourse': [414, 2296, 2369, 2438, 2579, 2588], 'R.L.': [415, 428, 2297, 2310, 2370, 2383, 2439, 2452, 2548, 2589, 2602], 'Mol.': [417, 512, 660, 948, 982, 1061, 1106, 1364, 1475, 1676, 1795, 1918, 2299, 2372, 2441, 2591, 3110, 3295, 3308], 'Biol.': [418, 446, 499, 560, 1107, 2300, 2328, 2373, 2401, 2442, 2470, 2566, 2592, 2620, 2836, 3111, 3210, 3272], '279:': [420, 2302, 2375, 2444, 2594], '331-345Crossref': [421, 2303, 2376, 2445, 2595], '(95)': [424, 2306, 2379, 2448, 2598], '6.Gourse': [427, 2309, 2382, 2451, 2601], 'Aiyar': [431, 2313, 2386, 2455, 2551, 2605], 'S.E.': [432, 2314, 2387, 2456, 2552, 2606], 'Barker': [433, 2315, 2388, 2457, 2553, 2607], 'M.M.': [434, 2316, 2389, 2458, 2554, 2608], 'Estrem': [435, 2317, 2390, 2459, 2555, 2609], 'S.T.': [436, 2318, 2391, 2460, 2556, 2610], 'Hirvonen': [437, 2319, 2392, 2461, 2557, 2611], 'C.A.': [438, 1104, 2320, 2393, 2462, 2558, 2612], 'Cold': [441, 857, 862, 1140, 1145, 1168, 1173, 1205, 1210, 1290, 1295, 2323, 2396, 2465, 2561, 2615], 'Spring.': [442, 2324, 2397, 2466, 2562, 2616], 'Harbor': [443, 859, 1142, 1170, 1207, 1292, 2325, 2398, 2467, 2563, 2617], 'Symp.': [444, 2326, 2399, 2468, 2564, 2618], 'Quant.': [445, 2327, 2400, 2469, 2565, 2619], '131-139Crossref': [449, 2331, 2404, 2473, 2569, 2623], '(24)': [452, 2334, 2407, 2476, 2572, 2626], 'can': [458, 1879, 2638], 'also': [459, 1951, 1983, 2115, 2206, 2538, 2716], 'act': [460], 'as': [461, 686, 1129, 1195, 1271, 2180, 2576, 2718, 2733, 2735, 2977], 'gene': [466, 1344, 1431, 1534, 2755], 'expression,': [467], 'large': [470, 2187], 'number': [471, 680, 1510], 'nucleotide': [477], 'their': [479, 535, 786, 820, 3017, 3026, 3432], '(7.Xiao': [486, 547], 'H.': [487, 548, 3323, 3331], 'Kalman': [488, 549], 'Ikehara': [490, 551], 'K.': [491, 552, 945, 961, 979, 1361, 1377, 1584, 1792, 1909, 3321, 3329], 'Zemel': [492, 553], 'Glaser': [494, 555], 'G.': [495, 556], 'Cashel': [496, 557, 630, 1445, 3104, 3107], 'Chem.': [500, 561, 2837, 3211, 3273], '1991;': [501, 562, 728], '266:': [502, 563], '5980-5990Abstract': [503, 564], 'Full': [504, 565, 2841, 2843, 3215, 3217, 3277, 3279], 'Text': [505, 566, 2842, 2844, 3216, 3218, 3278, 3280], 'PDF': [506, 567, 2845, 3219, 3281], '8.Nyström': [510], 'Gen.': [513], 'Genet.': [514], '1994;': [515, 1225, 1678], '245:': [516], '355-362Crossref': [517], '(39)': [520], 'For': [523, 1972, 3065, 3236], 'example,': [524, 3066, 3237], 'many': [525], 'operons': [526], 'encoding': [527], 'biosynthetic': [530], 'pathways': [531], 'cells': [538, 1354, 2135, 2181, 2517, 3083, 3136], 'lacking': [539, 574], '(relA': [541], 'spoT': [542, 577, 675, 1849], 'double': [543, 2050], 'mutants)': [544], 'are': [545, 832, 1495, 1842, 2148, 2177, 2193, 2514, 2542, 2665, 2745, 2868, 2916, 2925, 3231, 3428], 'polyauxotrophs': [546], 'In': [571, 2410, 3100], 'addition,': [572, 2411, 3101], 'mutants': [573, 600, 676, 704, 1421], 'functional': [575], 'relA': [576, 674, 754, 1417, 1848], 'or': [578, 1551, 1882, 2534, 3182, 3362], 'ς-factor,': [582], 'ςS,': [583], 'have': [584, 1400, 2672, 2990, 3074, 3120, 3256], 'found': [586, 1958], 'express': [588], 'similar': [589], 'phenotypes;': [590], 'explained': [594, 3036], 'fact': [597], 'ppGpp-deficient': [599, 3147], 'fail': [601], 'induce': [603, 678], 'regulon,': [606], 'turn,': [609], 'was': [610, 1181, 1262, 1269, 1319, 1619, 1961, 1969, 2011], 'demonstrated': [611], 'because': [614, 1761, 1999, 2119, 2278], '(9.Gentry': [622, 1437], 'Nguyen': [626, 1441], 'L.H.': [627, 1442], 'Jensen': [628, 1443], 'D.B.': [629, 1444], '1993;': [634, 1063, 1449], '175:': [635, 1450], '7982-7989Crossref': [636, 1451], '10.Lange': [640, 1455], 'R.': [641, 645, 723, 725, 899, 1456, 1460], 'Fischer': [642, 1457], 'Hengge-Aronis': [644, 724, 1333, 1459], '1995;': [648, 1463, 3112, 3297], '177:': [649, 1464], '4676-4680Crossref': [650, 1465], '11.Zgurskaya': [654, 1469], 'H.I.': [655, 1470], 'Keyhan': [656, 1471], 'Matin': [658, 1473], 'Microbiol.': [661, 949, 983, 1062, 1223, 1365, 1476, 1677, 1796, 1919, 3296, 3309], '1997;': [662, 1477, 3345], '24:': [663, 1478], '643-651Crossref': [664, 1479], '(67)': [667, 1482], 'Thus,': [670, 1595, 2066, 3154], 'failure': [672], 'different': [682, 3020], 'genes,': [684], 'such': [685, 2348], 'bolAand': [687], 'cfa,': [688, 1628, 1771], 'argued': [691, 2352, 2926], 'result': [695, 2013, 2249, 2948, 3089], 'low': [698], 'these': [703, 801, 2708, 2725, 2760, 2922, 3098, 3360, 3409], '(12.Eichel': [705, 1699], 'Chang': [707, 1701], 'Y.': [708, 1702, 3325], 'Riesenberg': [709, 1703], 'Cronan': [711, 1673, 1705], 'Jr.,': [712, 1674, 1706], 'J.E.': [713, 1675, 1707], '1999;': [716, 1710], '181:': [717, 1711], '572-576Crossref': [718, 1712], '13.Lange': [722], '173:': [729], '4474-4481Crossref': [730], '(266)': [733], 'If': [736, 2695], 'notion': [738], 'correct,': [740], 'it': [741, 2100, 3155], 'would': [742, 2715, 3005, 3022], 'possible': [744, 2853, 3157], 'restore': [746], 'spoTmutants': [755], 'ectopic': [757], 'overproduction': [758], 'ςS.': [760, 796, 2219], 'We': [761, 1399, 1686, 1941, 1957, 2198], 'here': [763, 1391, 2200], 'not': [767, 2222, 2740], 'case': [769], 'analyzed,': [776], 'PuspB,': [777], 'bolAP1,': [778], 'Pcfa,': [779], 'PfadL,': [781], 'all': [782, 890, 1422, 1831, 3008], 'wild-type': [793, 1555, 2031], 'Moreover,': [797], 'suppressed': [806, 1884], 'samerpoB': [809], 'alleles': [810, 2414], 'render': [812, 2416], 'some': [813, 2230, 2662, 2746], 'independent': [816], 'stasis.': [823], 'E.': [825, 1726, 2175], 'strains': [827, 1506, 2151], 'used': [828, 1687, 1810], 'work': [831, 2717, 3394], 'listed': [833], 'TableI.': [835], 'Cultures': [836], 'were': [837, 881, 931, 1127, 1193, 1252, 1303, 2052, 2697, 2762], 'grown': [838], 'liquid': [840], 'M9': [841], 'defined': [842, 1808], 'medium': [843, 1412, 1788, 1809], '(14.Sambrook': [844, 1155, 1277], 'Fritsch': [846, 1157, 1279], 'E.F.': [847, 1158, 1280], 'Maniatis': [848, 1159, 1281], 'Cloning:': [851, 1162, 1284], 'A': [852, 1163, 1285], 'Laboratory': [853, 860, 1143, 1164, 1171, 1208, 1286, 1293], 'Manual.': [854, 1165, 1287], '2nd': [855, 1166, 1288], 'Ed.': [856, 1167, 1289], 'Spring': [858, 863, 1141, 1146, 1169, 1174, 1206, 1211, 1291, 1296], 'Harbor,': [864, 1147, 1175, 1212, 1297], 'NY1989:': [865, 1176, 1298], '1.82-1.84Google': [866, 1177, 1299], 'Scholar)': [867, 1115, 1150, 1215, 1484, 1529, 1715, 2277, 3063, 3119], 'aerobically': [868], 'Erlenmeyer': [870], 'flasks': [871], 'rotary': [874], 'shaker': [875], '37': [877], '°C.': [878], 'media': [880], 'supplemented': [882], 'with': [883, 1216, 1603, 2288, 2346, 3176], 'glucose': [884], '(0.08%),': [885], 'thiamine': [886], '(10': [887], 'μm),': [888], '20': [891], 'acids': [893], 'excess': [895], '(15.Wanner': [896], 'B.L.': [897, 1090, 1518], 'Kodaira': [898], '1977;': [904], '130:': [905], '212-222Crossref': [906], 'When': [910, 1728], 'appropriate,': [911], 'kanamycin': [912], '(50': [913], 'μg/ml),': [914, 917, 920, 923, 926], 'chloramphenicol': [915], '(30': [916], 'rifampicin': [918], '(150': [919], 'tetracycline': [921], '(20': [922], 'carbenicillin': [924], '(100': [925], 'and/or': [927], 'isopropyl-β-d-thiogalactopyranoside': [928], '(200': [929], 'μm)': [930], 'added.Table': [932], 'IStrains': [933], 'plasmidsStrain/plasmidRelevant': [935], 'genotypeSource/referenceAD218MC4100': [936], 'λΦ(cfa-lacZ)A.': [937], 'Diez': [938, 3427], '(CMB,': [939, 974, 1082], 'Göteborg': [940, 975, 1083], 'University)AD99MC4100': [941], 'λΦ(bolAp1-lacZ)(18.Farewell': [942], 'Kvint': [944, 960, 978, 1360, 1376, 1583, 1791], 'Nyström': [946, 962, 980, 1220, 1362, 1378, 1585, 1793, 1916], '29:': [951, 985, 1367, 1798], '1039-1051Crossref': [952, 986, 1368, 1799], '(226)': [955, 989, 1371, 1802], 'Scholar)AF633MC4100': [957], 'λΦ(uspB-lacZ)(19.Farewell': [958], '180:': [967, 1383, 1590, 3388], '6140-6147Crossref': [968, 1384, 1591], 'Scholar)AF790AF633': [971], 'ΔspoT∷CmrA.': [972], 'Farewell': [973, 1912], 'University)AF908LS1349rpoS∷Knr(18.Farewell': [976], 'Scholar)CF1693MG1655ΔspoT∷Cmr': [991], 'ΔrelA∷Knr(3.Cashel': [992], 'Scholar)KK150AF790/pMMKatF2This': [1031], 'workKK159AD': [1032], '99ΔspoT∷CmrThis': [1033], 'workKK160KK159/pMMKatF2This': [1034], 'workKK180AF633ΔspoT∷Cmr': [1035], 'ΔrelA∷KnrThis': [1036, 1040, 1048], 'workKK206KK180rpoB3449(A532Δ)This': [1037], 'workKK210KK159rpoB3449(A532Δ)This': [1038], 'workKK220AD218ΔspoT∷Cmr': [1039], 'workKK224AD218rpoB3449(A532Δ)This': [1041], 'workKK225KK220rpoB3449(A532Δ)This': [1042], 'workKK226AD218ΔrpoS∷Tn10This': [1043], 'workKK227AD218rpoB3449(A532Δ)': [1044], 'rpoS∷KnrThis': [1045], 'workKK229KK220/pMMKatF2This': [1046], 'workKK235LS1349ΔspoT∷Cmr': [1047], 'workKK243AD99rpoS∷Tn10This': [1049], 'workKK236LS1349ΔspoT∷Cmr': [1050], 'ΔrelA∷Knr': [1051], 'rpoB3449(A532Δ)This': [1052], 'workKK244KK235/pMMKatF2This': [1053], 'workLS1349MC4100': [1054], 'λΦ(fadL-lacZ)(35.DiRusso': [1055], 'C.C.': [1056], 'Metzger': [1057], 'A.K.': [1058], 'Heimert': [1059], 'T.L.': [1060], '7:': [1064], '311-322Crossref': [1065], '(73)': [1068], 'Scholar)MC4100F−': [1070], 'araD139': [1071], 'Δ(argF-lac)U169rpsL150': [1072], 'relA1': [1073, 1559], 'flbB5301': [1074], 'deoC1': [1075], 'ptsF25': [1076], 'rbsRM.': [1077], 'Giskov': [1078], '(DTU,': [1079], 'Lyngby)MHY14rpoS∷Tn10M.': [1080], 'Jishage': [1081], 'University)pMMKatF2pAT153': [1084], 'carryingrpoS(20.Mulvey': [1085], 'M.R.': [1086, 1514], 'Sorby': [1087, 1515], 'P.A.': [1088, 1516], 'Triggs-Raine': [1089, 1517], 'Loewen': [1091, 1519], 'P.C.': [1092, 1520], 'Gene.': [1093, 1521], '1988;': [1094, 1108, 1522], '73:': [1095, 1523], '337-345Crossref': [1096, 1524], '(100)': [1099, 1527], 'Scholar)RpoB3449RLG1319rpoB3449(A532Δ)(32.Jin': [1101], 'D.J.': [1102, 1892, 2262, 2482, 2891, 2960, 3048], 'Gross': [1103], '202:': [1109], '45-58Crossref': [1110], '(543)': [1113], 'Open': [1116], 'table': [1117], 'new': [1120], 'tab': [1121], 'P1': [1122, 1633, 1765], 'transductions': [1123], 'plasmid': [1125, 1511], 'transformations': [1126], 'done': [1128], 'described': [1130, 1196, 1272], 'previously': [1131], 'Miller': [1133, 1198], '(16.Miller': [1134, 1199], 'Experiments': [1136, 1201], 'Genetics.': [1139, 1204], 'NY1972:': [1148, 1213], '201-205Google': [1149, 1214], 'Sambrook': [1152, 1274], 'et': [1153, 1275], 'al.': [1154, 1276], 'Plasmid': [1179], 'purification': [1180], 'performed': [1182, 1270, 2763], 'according': [1183], "manufacturer's": [1186], 'instructions': [1187], '(Qiagen,': [1188], 'Inc.).': [1189], 'Relative': [1190], 'β-galactosidase': [1191, 1234], 'determined': [1194], 'modifications': [1217], '(17.Albertson': [1218], 'N.H.': [1219], 'FEMS': [1222], 'Lett.': [1224], '117:': [1226], '181-188Crossref': [1227], '(46)': [1230], 'expressed': [1237, 2179], 'as:': [1238], '1000': [1239], '×A': [1240], '420/(A': [1241], '420': [1242], 'culture': [1243], '×': [1244, 1247], 'reaction': [1245], 'time': [1246], 'sample': [1248], 'volume).': [1249], 'All': [1250], 'experiments': [1251, 2761], 'repeated': [1253], 'several': [1254], 'times': [1255], 'ensure': [1257], 'reproducibility,': [1258], 'variation': [1261], 'less': [1263], 'than': [1264, 1414], '10%.': [1265], 'SDS-polyacrylamide': [1266], 'gel': [1267], 'electrophoresis': [1268], 'proteins': [1302], 'transferred': [1304], 'polyvinylidene': [1307], 'difluoride': [1308], 'filter': [1309], '(Immobilon-P,': [1310], 'Millipore)': [1311], 'semi-dry': [1313], 'blotting': [1314], '(Schleicher': [1315], 'Schuell).': [1317], 'quantitated': [1320], 'from': [1321, 1764, 2229, 2235, 2250, 2256, 2724, 2954, 3090], 'Western': [1322], 'blots': [1323], 'cell': [1325, 2144, 2418], 'extracts': [1326], 'anti-ςS': [1328], 'antibodies': [1329, 3438], 'provided': [1330], 'Dr.': [1332], 'peroxidase': [1336], 'chemiluminescence': [1337], 'kit': [1338], '(Roche': [1339], 'Biochemicals).': [1341], 'uspB': [1343, 1540, 1575], 'single,': [1347], 'induced': [1352, 3010], 'when': [1353, 2134], 'enter': [1355, 2136, 2182], '(18.Farewell': [1358, 1789], '19.Farewell': [1374], 'report': [1390], '(Fig.1': [1397], 'A).': [1398], 'confirmed': [1401], 'response': [1405, 3355], '(ppGpp': [1406], 'accumulation)': [1407], 'SpoT': [1409], 'rather': [1413], 'RelA': [1415], '(i.e.': [1416], '+,relA1,': [1418], 'ΔrelA': [1420], 'give': [1423, 2639], 'identical': [1424, 2053], 'results).': [1425], 'dependence': [1427, 1875, 3018], 'confirms': [1434], 'previous': [1435], 'data': [1436], 'demonstrating': [1485], 'accumulation': [1492, 2942], 'partly': [1496, 1933, 2419], 'dependent': [1497, 1641, 1821, 2093], 'ppGpp.': [1499, 1940, 2197, 2694], 'However,': [1500, 1805, 2522, 2732], 'introducing': [1502], 'into': [1503, 1720, 2028, 2034], 'our': [1504, 3396], 'reporter': [1505], 'copy': [1509], 'pMMKatF2': [1512, 1571], '(20.Mulvey': [1513], 'carries': [1531], 'structural': [1533], 'forrpoS,': [1535], 'cannot': [1542], 'rescued': [1544, 1843], 'producing': [1546], 'close': [1549], 'to,': [1550], 'somewhat': [1552, 1982], 'higher': [1553, 3092], 'than,': [1554], 'spoTmutant': [1560], '(Fig.': [1561, 1766, 1868, 2097], '1,': [1562], 'B': [1563], 'C).': [1565, 1825], 'It': [1566, 1851, 2220, 2851], 'should': [1567, 2101], 'noted': [1569, 1735, 2103], 'fully': [1572], 'rescues': [1573], 'anrpoS': [1578], 'null': [1579, 2026], 'mutant': [1580, 2002, 2051, 2062, 2113, 2520], '(19.Farewell': [1581], 'induced,': [1598], 'PuspBrequires': [1599], 'concert': [1602], 'EςS': [1605], 'holoenzyme.': [1606], 'To': [1607, 2006], 'investigate': [1608], 'whether': [1609, 1943, 2008], 'PuspB': [1618], 'promoter-specific,': [1620], 'tested': [1622, 1942], 'following': [1624], 'genes:': [1626], 'bolA,': [1627], 'fadL.': [1630], 'bolA': [1632], '(used': [1635], 'work)': [1638], 'strictly': [1640], 'vivo': [1651, 3404], '(Fig.2': [1652, 1824], 'A),': [1653], 'whereas': [1654, 2086], 'cfagene': [1656], 'two': [1658], 'promoters,': [1659, 2709, 2923], 'one': [1660, 2680, 2710], 'P1,': [1663], 'other,': [1668], 'P2,': [1669], '(21.Wang': [1671], 'A.Y.': [1672], '11:': [1679], '1009-1017Crossref': [1680], '(119)': [1683], 'construct': [1689, 1719], 'region': [1692], 'containing': [1693], 'fused': [1696], 'lacZ': [1698], 'moved': [1717], 'λ': [1722], 'att': [1723], 'site': [1724], 'coli.': [1727], 'single-copy': [1731], 'chromosomal': [1732, 1777], 'fusion,': [1733], 'about': [1737], '75%': [1738], 'cfarequires': [1745], 'residual': [1750, 1856, 2106], 'occurs': [1752, 2537], 'absence': [1755, 1863, 1938], 'sigma': [1758], 'factor,': [1759], 'presumably': [1760], 'transcription': [1763, 2122, 2228, 2234, 2723, 2767, 2986, 3262], '2': [1767, 1869], 'B).': [1768], 'fadL-lacZ': [1778], 'fusion': [1779, 2074], 'depends': [1780], 'ς70': [1785, 3126], 'LB': [1787], 'work,': [1813], 'offadL': [1818], 'primarily': [1820, 2094], 'As': [1826, 2037, 2938], 'seen': [1827, 2038], 'Fig.': [1829], '2,': [1830], 'analyzed': [1835], 'induction,': [1839], 'none': [1841], 'ςSoverproduction': [1845], 'mutant.': [1850], 'noteworthy': [1853], 'cfa': [1859], 'observed': [1860], 'B;': [1870], 'see': [1871], 'below).': [1872], 'Eς70-dependent': [1877, 2172], 'totally': [1881], 'partially': [1883], 'rpoB3449': [1887, 2001, 2049, 2061, 2077, 2155, 2160], 'allele': [1888, 1945, 1978, 2027], '(22.Zhou': [1889, 2259, 2888, 2957, 3045], 'Y.N.': [1890, 2260, 2480, 2889, 2958, 3046], 'Jin': [1891, 2261, 2481, 2887, 2890, 2959, 3044, 3047], '95:': [1901, 2271, 2491, 2900, 2969, 3057], '2908-2913Crossref': [1902, 2272, 2492, 2901, 2970, 3058], '(187)': [1905, 2275, 2495, 2904, 2973, 3061], '23.Kvint': [1908], 'Hosbond': [1910], 'C.': [1911, 3415], 'Nybroe': [1914], 'O.': [1915], '2000;': [1920, 2838], '35:': [1921], '435-443Crossref': [1922], '(47)': [1925], 'which': [1928, 1995, 2509, 3143, 3225], 'renders': [1929], 'constitutively': [1934, 2004, 2420], 'could': [1946, 2681, 3034], 'alleviate': [1947], 'analyzed.': [1956], 'case,': [1963], 'although': [1964], 'degree': [1966, 3249], 'suppression': [1968], 'promoter-dependent': [1970], '(Fig.3).': [1971], 'instance,': [1973], 'noticed': [1975], 'therpoB3449': [1977, 2035], 'up-regulated': [1979], 'exponential': [1985, 2064], 'least': [1988], 'three': [1990], 'tested,': [1994], 'may': [1996, 2350, 2685, 3073, 3088, 3180, 3226, 3356], 'expected': [1998], '"stringent."': [2005], 'determine': [2007], 'ς70-associated': [2020], 'RNAP,': [2021], 'introduced': [2023], 'rpoS': [2025, 2048, 2112, 2153, 2159], 'otherwise': [2030], 'strain': [2032, 2078], 'strain.': [2036], 'Fig.4,': [2040], 'expression': [2044, 2058, 2071, 2107, 2126, 2756], 'ofcfa-lacZ': [2045], 'level': [2069, 3093], 'growth': [2080], 'due': [2082, 2869], 'Eς70': [2084], '4).': [2098], 'Finally,': [2099, 3178], 'cfa-lacZ': [2109], 'an': [2111, 2341, 2423, 2728], 'inducible': [2118], 'ppGpp-dependent': [2121, 2875], 'Eς70.Figure': [2124], '4Pcfa-lacZ': [2125], 'full': [2132], 'β-Galactosidase': [2139], 'activities': [2140], '(closed': [2141], 'symbols)': [2142, 2147], 'density': [2145], '(open': [2146], 'shown': [2149, 3121], 'carrying': [2152], '(KK226,circles),': [2154], '(KK224,': [2156], 'squares),': [2157], '(KK227,': [2161], 'triangles).View': [2162], 'Large': [2163], 'Image': [2164], 'Figure': [2165], 'ViewerDownload': [2166], 'Hi-res': [2167], 'image': [2168], 'Download': [2169], '(PPT)': [2170], 'Many': [2171], 'increasingly': [2178], 'fraction': [2188], 'corresponding': [2191], 'positively': [2194, 2543, 2666, 2917], 'regulated': [2195, 2544, 2667, 2918], 'holds': [2207], 'EςS-dependent': [2209], 'completely': [2223], 'understood': [2224], 'how': [2225], 'activates': [2227], 'while': [2232], 'inhibiting': [2233], 'other': [2236, 3229, 3363], '(stringent': [2237], 'promoters),': [2238], 'notably': [2239], 'rRNA,': [2240], 'promoters.': [2241, 3193], 'Negative': [2242], 'suggested': [2247, 2577, 2946, 3258], 'dissociation': [2252, 2951], 'ppGpp-programmed': [2254], 'drastically': [2280], 'reduces': [2281], 'complex': [2287, 2345], 'rrnP1': [2338], 'forms': [2340], 'intrinsically': [2342], 'unstable': [2343], 'RNAP;': [2347], 'especially': [2355], 'sensitive': [2356, 2930], 'destabilizing': [2359], 'effects': [2360, 2504, 2646, 2856], 'rpoB': [2413], 'form': [2422], 'destabilizes': [2426], 'vitro': [2431, 2730], '22.Zhou': [2479], 'Thus': [2498], 'β-mutant': [2500, 2535, 3086], 'RNAPs': [2501, 2536], 'mimic': [2502], 'elevated': [2506, 3133, 3242], 'levels,': [2508], 'explains': [2510], 'why': [2511], 'down-regulated': [2515], 'expressing': [2518, 3084], 'RNAP.': [2521, 2997], 'half-life': [2527], '(6.Gourse': [2547], 'Possibly,': [2575], 'co-workers': [2581], 'rise': [2640], 'negative': [2643], 'depending': [2647], 'intrinsic': [2650], 'kinetic': [2651, 2688], 'properties': [2652], 'target': [2655], 'promoter.': [2656], 'half-lives': [2658], 'reported': [2674], 'extremely': [2677], 'long,': [2678], 'argue': [2682, 3006], 'problem': [2689], 'mitigated': [2692], 'entire': [2699], 'role': [2700], 'regulation': [2706], 'might': [2711], 'expect': [2712], 'factor': [2721], 'assay.': [2731], 'far': [2734], 'know,': [2737], 'always': [2741], 'case.': [2743], 'There': [2744], 'examples': [2747], 'effect': [2751], 'vitro,': [2758], 'but': [2759], 'coupled': [2766], 'translation': [2768], 'assay': [2769], '(24.Stephens': [2770], 'J.C.': [2771], 'Artz': [2772, 2793, 2816], 'S.W.': [2773, 2794, 2817], 'Ames': [2774], 'B.N.': [2775], '1975;': [2783], '72:': [2784], '4389-4393Crossref': [2785], '(152)': [2788], '25.Primakoff': [2791], 'P.': [2792], '1979;': [2802], '76:': [2803], '1726-1730Crossref': [2804], '(36)': [2807], '26.Riggs': [2810], 'D.L.': [2811], 'Mueller': [2812], 'R.D.': [2813], 'Kwan': [2814], 'H.S.': [2815], '1986;': [2825], '83:': [2826], '9333-9337Crossref': [2827], '(41)': [2830], '27.Choy': [2833], '275:': [2839], '6783-6789Abstract': [2840], '(32)': [2848], 'apparently': [2862], 'more': [2871, 2980, 3166], 'indirect': [2872], 'effects,': [2873], 'including': [2874], 'changes': [2876], 'availability.': [2879], 'According': [2880], 'Zhou': [2885, 3042], 'recruitment': [2908], 'rate-limiting': [2911], 'step': [2912], 'therefore,': [2924], 'very': [2929], 'concentration': [2933], 'free': [2935, 3095], 'elaborated': [2939], 'above,': [2940], 'consequence,': [2979], 'becomes': [2982], 'available': [2983], 'initiate': [2985], 'relatively': [2992, 3076], 'poor': [2993, 3077], 'ability': [2994, 3078, 3187, 3370], 'recruit': [2996, 3080], 'Following': [2998], 'assumptions': [3000], 'model,': [3003], 'conditions': [3012, 3160], 'stringency,': [3014], 'regardless': [3015], 'ς-factors,': [3021], 'induction;': [3027], 'presented': [3030], 'paper': [3033], 'within': [3037], 'framework': [3039], 'model.': [3064], 'up-regulation': [3067], '(which': [3072], 'RNAP)': [3081], 'cells.': [3099], '(28.Hernandez': [3105], '252:': [3113], '536-549Crossref': [3114], '(84)': [3117], 'amounts': [3124], 'bound': [3127], 'E': [3129, 3169, 3175], '(RNAP': [3130], 'core)': [3131], 'ppGppO': [3135], 'mutation': [3140], 'rpoD,': [3142], 'epistatic': [3145], 'defects,': [3148], 'lower': [3149], 'amount': [3151], 'Eς70.': [3153], 'allow': [3161], 'alternative': [3162], 'ς-factors': [3163], 'compete': [3165], 'successfully': [3167], 'lowering': [3171], 'programming': [3173], 'ς70.': [3177], 'directly': [3181], 'indirectly': [3183], 'aid': [3184], 'transcribe': [3191, 3374], 'works': [3195], 'poorly': [3196], 'vitrotranscription': [3199], 'systems': [3200], '(29.Kusano': [3201, 3263], 'Ding': [3203, 3265, 3411], 'Q.': [3204, 3266, 3288], '1996;': [3212, 3274], '271:': [3213, 3275], '1998-2004Abstract': [3214, 3276], '(126)': [3222, 3284], 'indicate': [3227], 'factors': [3230, 3365], 'needed': [3232], 'transcription.': [3235], 'polyphosphate,': [3241], 'potassium': [3245], 'glutamate,': [3246], 'supercoiling': [3251], 'DNA': [3254], 'template': [3255], 'influence': [3260], '30.Ding': [3287], 'Kusano': [3289], 'Villarejo': [3291], '4:': [3298], '649-656Crossref': [3299], '(68)': [3301], '31.Ohlsen': [3304], 'K.L.': [3305], 'Gralla': [3306], 'J.D.': [3307], '1992;': [3310], '6:': [3311], '2243-2251Crossref': [3312], '(48)': [3315], '33.Shiba': [3318], 'Tsutsumi': [3320], 'Yano': [3322], 'Ihara': [3324], 'Kameda': [3326], 'Tanaka': [3328], 'Takahashi': [3330], 'Munekata': [3332], 'Rao': [3334], 'N.N.': [3335, 3380], 'Kornberg': [3336, 3383], '94:': [3346], '11210-11215Crossref': [3347], '(160)': [3350], 'alter': [3357], 'any': [3358], 'variables': [3361], 'unknown': [3364], 'thus': [3367], 'affect': [3368], 'cognate': [3376], '(e.g.': [3378], 'Ref.34.Rao': [3379], 'Liu': [3381], '2186-2193Crossref': [3389], 'Future': [3393], 'laboratory': [3397], 'will': [3398], 'use': [3399], 'vitroand': [3402], 'methods': [3405], 'distinguish': [3407], 'between': [3408], 'models.': [3410], 'Jun': [3412], 'Jin,': [3413], 'Concetta': [3414], 'DiRusso,': [3416], 'Regine': [3417], 'Hengge-Aronis,': [3418], 'Mårten': [3419], 'Hammar,': [3420], 'Miki': [3421], 'Jishage,': [3422], 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