Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2079449212', 'doi': 'https://doi.org/10.1002/1097-4695(200008)44:2<219::aid-neu11>3.0.co;2-w', 'title': 'Molecular basis of semaphorin-mediated axon guidance', 'display_name': 'Molecular basis of semaphorin-mediated axon guidance', 'publication_year': 2000, 'publication_date': '2000-01-01', 'ids': {'openalex': 'https://openalex.org/W2079449212', 'doi': 'https://doi.org/10.1002/1097-4695(200008)44:2<219::aid-neu11>3.0.co;2-w', 'mag': '2079449212', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10934324'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/1097-4695(200008)44:2<219::aid-neu11>3.0.co;2-w', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S68990794', 'display_name': 'Journal of Neurobiology', 'issn_l': '0022-3034', 'issn': ['0022-3034', '1097-4695'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5074016785', 'display_name': 'Fumio Nakamura', 'orcid': 'https://orcid.org/0000-0003-2029-6083'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Fumio Nakamura', 'raw_affiliation_strings': ['Department of Neurology'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002901691', 'display_name': 'Robert G. Kalb', 'orcid': 'https://orcid.org/0000-0002-2368-9280'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Robert G. Kalb', 'raw_affiliation_strings': ['Department of Neurology'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026147594', 'display_name': 'Stephen M. Strittmatter', 'orcid': 'https://orcid.org/0000-0001-8188-3092'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210164692', 'display_name': 'Medical Research Foundation', 'ror': 'https://ror.org/05q2q3076', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210164692']}], 'countries': ['GB', 'US'], 'is_corresponding': True, 'raw_author_name': 'Stephen M. Strittmatter', 'raw_affiliation_strings': ['Department of Neurology', 'SMS is an Investigator of the Patrick and Catherine Weldon Donaghue Medical Research Foundation.', 'Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, PO Box 20818, New Haven, Connecticut 06520'], 'affiliations': [{'raw_affiliation_string': 'Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, PO Box 20818, New Haven, Connecticut 06520', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'Department of Neurology', 'institution_ids': []}, {'raw_affiliation_string': 'SMS is an Investigator of the Patrick and Catherine Weldon Donaghue Medical Research Foundation.', 'institution_ids': ['https://openalex.org/I4210164692']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5026147594'], 'corresponding_institution_ids': ['https://openalex.org/I32971472', 'https://openalex.org/I4210164692'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.78, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 300, 'citation_normalized_percentile': {'value': 0.836623, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '44', 'issue': '2', 'first_page': '219', 'last_page': '229'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Molecular Mechanisms of Angiogenesis and Vascular Function', 'score': 0.9706, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Adult Neurogenesis and Brain Development', 'score': 0.9562, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sema3a', 'display_name': 'SEMA3A', 'score': 0.93434143}, {'id': 'https://openalex.org/keywords/growth-cone', 'display_name': 'Growth cone', 'score': 0.9129795}, {'id': 'https://openalex.org/keywords/plexin', 'display_name': 'Plexin', 'score': 0.8863252}, {'id': 'https://openalex.org/keywords/neuropilin', 'display_name': 'Neuropilin', 'score': 0.7496933}, {'id': 'https://openalex.org/keywords/semaphorins', 'display_name': 'Semaphorins', 'score': 0.577886}, {'id': 'https://openalex.org/keywords/axon-guidance', 'display_name': 'Axon guidance', 'score': 0.563745}], 'concepts': [{'id': 'https://openalex.org/C132538176', 'wikidata': 'https://www.wikidata.org/wiki/Q24768287', 'display_name': 'Semaphorin', 'level': 3, 'score': 0.9752573}, {'id': 'https://openalex.org/C2776805952', 'wikidata': 'https://www.wikidata.org/wiki/Q18035334', 'display_name': 'SEMA3A', 'level': 4, 'score': 0.93434143}, {'id': 'https://openalex.org/C135903288', 'wikidata': 'https://www.wikidata.org/wiki/Q559423', 'display_name': 'Growth cone', 'level': 3, 'score': 0.9129795}, {'id': 'https://openalex.org/C2779841796', 'wikidata': 'https://www.wikidata.org/wiki/Q1188964', 'display_name': 'Plexin', 'level': 4, 'score': 0.8863252}, {'id': 'https://openalex.org/C69125201', 'wikidata': 'https://www.wikidata.org/wiki/Q2034716', 'display_name': 'Axon guidance', 'level': 3, 'score': 0.7915907}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.77297145}, {'id': 'https://openalex.org/C106420622', 'wikidata': 'https://www.wikidata.org/wiki/Q1188971', 'display_name': 'Neuropilin', 'level': 5, 'score': 0.7496933}, {'id': 'https://openalex.org/C34425596', 'wikidata': 'https://www.wikidata.org/wiki/Q18033463', 'display_name': 'Neuropilin 1', 'level': 4, 'score': 0.7496872}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6477212}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.5367163}, {'id': 'https://openalex.org/C2779530196', 'wikidata': 'https://www.wikidata.org/wiki/Q178999', 'display_name': 'Axon', 'level': 2, 'score': 0.3907948}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.20148331}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17863214}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001369', 'descriptor_name': 'Axons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020439', 'descriptor_name': 'Growth Cones', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001369', 'descriptor_name': 'Axons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020439', 'descriptor_name': 'Growth Cones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039942', 'descriptor_name': 'Neuropilin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040121', 'descriptor_name': 'Semaphorin-3A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/1097-4695(200008)44:2<219::aid-neu11>3.0.co;2-w', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S68990794', 'display_name': 'Journal of Neurobiology', 'issn_l': '0022-3034', 'issn': ['0022-3034', '1097-4695'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10934324', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 72, 'referenced_works': ['https://openalex.org/W1506635126', 'https://openalex.org/W1539537345', 'https://openalex.org/W1542854943', 'https://openalex.org/W1594867935', 'https://openalex.org/W1595029695', 'https://openalex.org/W1596187859', 'https://openalex.org/W1646460047', 'https://openalex.org/W1788354698', 'https://openalex.org/W1964361550', 'https://openalex.org/W1966116208', 'https://openalex.org/W1968646220', 'https://openalex.org/W1971765286', 'https://openalex.org/W1978146656', 'https://openalex.org/W1987427290', 'https://openalex.org/W1987868279', 'https://openalex.org/W1990983421', 'https://openalex.org/W1992111877', 'https://openalex.org/W1993786495', 'https://openalex.org/W1994088328', 'https://openalex.org/W1994912172', 'https://openalex.org/W1997937844', 'https://openalex.org/W1998413748', 'https://openalex.org/W2003766638', 'https://openalex.org/W2007067622', 'https://openalex.org/W2012585750', 'https://openalex.org/W2013184812', 'https://openalex.org/W2013745227', 'https://openalex.org/W2021087194', 'https://openalex.org/W2023193192', 'https://openalex.org/W2024722673', 'https://openalex.org/W2027810531', 'https://openalex.org/W2039242518', 'https://openalex.org/W2041258662', 'https://openalex.org/W2041700814', 'https://openalex.org/W2046034465', 'https://openalex.org/W2047166961', 'https://openalex.org/W2048607748', 'https://openalex.org/W2051053924', 'https://openalex.org/W2051392943', 'https://openalex.org/W2052248831', 'https://openalex.org/W2055613750', 'https://openalex.org/W2057650712', 'https://openalex.org/W2058403440', 'https://openalex.org/W2060992926', 'https://openalex.org/W2061341372', 'https://openalex.org/W2063989616', 'https://openalex.org/W2064173164', 'https://openalex.org/W2064994129', 'https://openalex.org/W2067817921', 'https://openalex.org/W2068599628', 'https://openalex.org/W2069472625', 'https://openalex.org/W2071241028', 'https://openalex.org/W2073569988', 'https://openalex.org/W2077515896', 'https://openalex.org/W2081441817', 'https://openalex.org/W2081913959', 'https://openalex.org/W2094426096', 'https://openalex.org/W2095855239', 'https://openalex.org/W2103686156', 'https://openalex.org/W2124248841', 'https://openalex.org/W2124829726', 'https://openalex.org/W2126542948', 'https://openalex.org/W2134843840', 'https://openalex.org/W2135255676', 'https://openalex.org/W2150516905', 'https://openalex.org/W2153556389', 'https://openalex.org/W2163339962', 'https://openalex.org/W2184848481', 'https://openalex.org/W2344433860', 'https://openalex.org/W2480206292', 'https://openalex.org/W4299885251', 'https://openalex.org/W636920547'], 'related_works': ['https://openalex.org/W3176779758', 'https://openalex.org/W3165189984', 'https://openalex.org/W2141551235', 'https://openalex.org/W2079449212', 'https://openalex.org/W2047166961', 'https://openalex.org/W2000480493', 'https://openalex.org/W1987651098', 'https://openalex.org/W1981917866', 'https://openalex.org/W1971858644', 'https://openalex.org/W1565556684'], 'abstract_inverted_index': {'The': [0, 14, 105], 'semaphorin': [1, 213], 'family': [2, 19, 139], 'of': [3, 7, 17, 41, 69, 92, 108, 140, 154, 199, 209, 228], 'proteins': [4], 'constitute': [5], 'one': [6], 'the': [8, 38, 75, 80, 90, 114, 133, 143, 155, 172, 196, 226], 'major': [9], 'cues': [10, 215], 'for': [11, 37, 63, 112, 180, 189, 212, 219, 225], 'axonal': [12], 'guidance.': [13], 'prototypic': [15], 'member': [16], 'this': [18], 'is': [20, 61, 67, 110, 146, 164, 178], 'Sema3A,': [21, 99], 'previously': [22], 'designated': [23], 'semD/III': [24], 'or': [25, 125], 'collapsin-1.': [26], 'Sema3A': [27, 47, 64, 72], 'acts': [28], 'as': [29], 'a': [30, 71, 138], 'diffusible,': [31], 'repulsive': [32], 'guidance': [33, 214, 222], 'cue': [34], 'in': [35, 151, 184], 'vivo': [36], 'peripheral': [39], 'projections': [40], 'embryonic': [42], 'dorsal': [43], 'root': [44], 'ganglion': [45], 'neurons.': [46], 'binds': [48], 'with': [49, 84], 'high': [50], 'affinity': [51], 'to': [52, 74, 103, 119, 148, 171], 'neuropilin-1': [53, 60], 'on': [54, 89], 'growth': [55, 76, 93, 120, 126, 192, 200, 229], 'cone': [56, 77, 121, 127, 193, 201, 230], 'filopodial': [57], 'tips.': [58], 'Although': [59], 'required': [62, 179], 'action,': [65], 'it': [66], 'incapable': [68], 'transmitting': [70], 'signal': [73, 115], 'interior.': [78], 'Instead,': [79], 'Sema3A/neuropilin-1': [81], 'complex': [82], 'interacts': [83], 'another': [85], 'transmembrane': [86], 'protein,': [87, 176], 'plexin,': [88], 'surface': [91], 'cones.': [94], 'Certain': [95], 'semaphorins,': [96], 'other': [97, 220], 'than': [98], 'can': [100], 'bind': [101], 'directly': [102], 'plexins.': [104], 'intracellular': [106, 130], 'domain': [107], 'plexin': [109, 160], 'responsible': [111], 'initiating': [113], 'transduction': [116], 'cascade': [117, 131], 'leading': [118], 'collapse,': [122, 194], 'axon': [123, 182, 221], 'repulsion,': [124], 'turning.': [128], 'This': [129], 'involves': [132], 'monomeric': [134], 'G-protein,': [135], 'Rac1,': [136], 'and': [137, 224], 'neuronal': [141], 'proteins,': [142], 'CRMPs.': [144], 'Rac1': [145, 162], 'likely': [147], 'be': [149], 'involved': [150], 'semaphorin-induced': [152], 'rearrangements': [153], 'actin': [156], 'cytoskeleton,': [157], 'but': [158, 195], 'how': [159], 'controls': [161], 'activity': [163], 'not': [165, 204], 'known.': [166], 'Vertebrate': [167], 'CRMPs': [168, 186, 202], 'are': [169, 187, 203], 'homologous': [170], 'Caenorhabditis': [173], 'elegans': [174], 'unc-33': [175], 'which': [177], 'proper': [181], 'morphology': [183], 'worms.': [185], 'essential': [188], 'Sema3A-induced,': [190], 'neuropilin–plexin-mediated': [191], 'molecular': [197], 'interactions': [198], 'well': [205], 'defined.': [206], 'Mechanistic': [207], 'aspects': [208], 'plexin-based': [210], 'signaling': [211], 'may': [216], 'have': [217], 'implications': [218], 'events': [223], 'basis': [227], 'motility.': [231], '©': [232], '2000': [233, 243], 'John': [234], 'Wiley': [235], '&': [236], 'Sons,': [237], 'Inc.': [238], 'J': [239], 'Neurobiol': [240], '44:': [241], '219–229,': [242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2079449212', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-13T10:17:02.020984', 'created_date': '2016-06-24'}